[Hub]/) : Traits : Medication: Simvastatin :

chr1:61,510,619-63,844,736

Best TWAS P=8.33e-12 · Best GWAS P=2.43e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum INADL 0.22 0.03 lasso 6 0.05 1.3e-03 -6.8 5.5 3.6e-08 -0.72 0.06 0.64 FALSE
2 GTEx Artery Aorta DOCK7 0.14 0.08 lasso 4 0.09 1.2e-05 -6.8 6.6 3.2e-11 -0.88 0.05 0.95 FALSE
3 GTEx Artery Tibial DOCK7 0.07 0.07 enet 20 0.07 3.5e-06 -6.8 6.6 4.1e-11 -0.94 0.05 0.95 FALSE
4 GTEx Cells Transformed fibroblasts DOCK7 0.23 0.21 lasso 5 0.28 4.9e-21 -6.2 6.4 1.9e-10 -0.91 0.11 0.89 FALSE
5 GTEx Esophagus Mucosa DOCK7 0.15 0.04 lasso 5 0.02 1.0e-02 -6.8 6.0 2.0e-09 -0.76 0.06 0.84 FALSE
6 GTEx Skin Not Sun Exposed Suprapubic DOCK7 0.17 0.01 lasso 2 0.00 2.5e-01 -6.7 6.8 1.4e-11 -0.95 0.06 0.64 FALSE
7 GTEx Skin Sun Exposed Lower leg DOCK7 0.09 0.10 lasso 3 0.10 2.7e-08 -6.7 6.8 1.3e-11 -0.96 0.05 0.95 FALSE
8 GTEx Spleen DOCK7 0.28 0.14 enet 33 0.22 2.1e-06 -6.8 5.8 8.6e-09 -0.67 0.06 0.88 FALSE
9 GTEx Whole Blood DOCK7 0.06 0.00 lasso 6 0.00 1.6e-01 -6.2 6.2 4.5e-10 -0.94 0.07 0.86 FALSE
10 GTEx Whole Blood USP1 0.05 0.02 lasso 1 0.02 1.0e-02 -6.8 6.8 1.5e-11 -0.96 0.04 0.91 FALSE
11 NTR Blood DOCK7 0.02 0.00 blup 647 0.01 1.5e-03 -6.7 6.1 8.1e-10 -0.83 0.05 0.95 FALSE
12 ROSMAP Brain Pre-frontal Cortex DOCK7 0.06 0.06 lasso 6 0.06 3.7e-08 -6.7 -6.0 1.7e-09 0.89 0.05 0.95 FALSE
13 YFS Blood DOCK7 0.05 0.04 lasso 8 0.05 1.3e-14 -6.7 6.4 1.7e-10 -0.93 0.05 0.95 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma DOCK7 0.01 0.01 blup 85 0.01 1.1e-03 -6.7 6.8 8.3e-12 -0.96 0.05 0.92 TRUE
15 The Cancer Genome Atlas Colon Adenocarcinoma DOCK7 0.07 0.06 blup 83 0.06 2.1e-04 -6.8 6.4 1.7e-10 -0.93 0.04 0.94 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DOCK7 0.12 0.05 lasso 8 0.07 9.2e-09 -6.7 5.9 3.2e-09 -0.86 0.06 0.94 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ANGPTL3 0.04 0.04 lasso 2 0.04 3.0e-05 -6.8 6.4 1.4e-10 -0.90 0.02 0.97 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOCK7 0.04 0.01 enet 11 0.04 5.6e-05 -6.8 5.7 1.6e-08 -0.69 0.04 0.90 FALSE
19 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma DOCK7 0.06 0.07 blup 86 0.07 1.0e-04 -6.8 6.6 4.0e-11 -0.94 0.05 0.95 FALSE
20 The Cancer Genome Atlas Lung Adenocarcinoma DOCK7 0.04 0.01 enet 3 0.02 3.0e-03 -6.7 6.8 1.3e-11 -0.98 0.04 0.75 FALSE
21 The Cancer Genome Atlas Pancreatic Adenocarcinoma DOCK7 0.08 0.05 enet 29 0.10 7.8e-05 -7.0 6.4 1.7e-10 -0.91 0.04 0.94 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma DOCK7 0.05 0.03 blup 86 0.02 1.6e-03 -5.0 6.7 1.9e-11 -0.90 0.06 0.90 FALSE