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chr1:108,854,166-110,742,615

Best TWAS P=9.07e-36 · Best GWAS P=7.01e-36 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	-8.53	7.4	1.0e-13	-0.59	0.10	0.32	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	2.87	-8.1	6.0e-16	0.63	0.02	0.98	FALSE
3	GTEx	Esophagus Mucosa	GPSM2	0.17	0.02	enet	34	0.07	1.5e-05	-1.98	-5.4	5.5e-08	0.22	0.50	0.09	FALSE
4	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	-12.38	-12.2	2.1e-34	0.96	0.00	0.99	FALSE
5	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	-12.38	-12.4	3.2e-35	1.00	0.01	0.99	FALSE
6	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	-0.93	-7.7	1.5e-14	0.70	0.08	0.79	FALSE
7	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	-12.38	-12.3	1.1e-34	0.99	0.01	0.99	FALSE
8	GTEx	Nerve Tibial	SYPL2	0.09	0.00	enet	27	0.05	1.9e-04	-5.66	5.2	1.5e-07	-0.34	0.09	0.26	FALSE
9	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	-10.11	-9.6	8.7e-22	0.75	0.01	0.98	FALSE
10	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	-12.51	-12.5	9.1e-36	1.00	0.00	1.00	TRUE
11	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	-12.38	-10.4	1.7e-25	0.82	0.00	1.00	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	-12.38	-12.2	2.5e-34	0.96	0.00	1.00	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	AMIGO1	0.08	0.03	blup	404	0.03	8.7e-05	-4.34	-5.2	1.6e-07	0.25	0.93	0.01	FALSE
14	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	-12.38	-11.1	1.6e-28	0.86	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	-10.11	-9.8	1.1e-22	0.80	0.02	0.91	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	-12.24	-8.8	1.7e-18	0.73	0.01	0.75	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	-12.51	-8.5	2.6e-17	0.58	0.00	0.80	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	-10.11	-10.1	5.0e-24	0.75	0.01	0.84	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSRC1	0.14	0.05	enet	6	0.08	7.5e-09	1.37	-6.9	6.3e-12	0.50	0.17	0.59	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	-11.80	-11.5	8.2e-31	0.92	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MYBPHL	0.09	0.07	blup	46	0.06	5.7e-04	0.89	-5.2	1.7e-07	0.55	0.03	0.52	FALSE
22	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	-12.07	-12.0	5.7e-33	0.95	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	-12.51	-11.8	6.8e-32	0.94	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	-12.24	-9.8	7.9e-23	0.77	0.01	0.92	FALSE
25	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	-8.26	-8.5	1.5e-17	0.67	0.01	0.38	FALSE
26	The Cancer Genome Atlas	Stomach Adenocarcinoma	CELSR2	0.08	0.00	blup	62	0.02	8.1e-03	-1.08	-5.9	3.9e-09	0.50	0.01	0.27	FALSE
27	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	-12.38	-9.4	6.0e-21	0.76	0.00	0.99	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	SORT1	0.04	0.01	blup	60	0.03	4.4e-03	-12.38	-7.2	6.4e-13	0.64	0.00	0.81	FALSE