[Hub]/) : Traits : Medication: Simvastatin : ←

chr20:61,989,111-62,912,463

Best TWAS P=8.15e-09 · Best GWAS P=2.36e-08 conditioned to 0.668

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	-5.6	-5.8	8.2e-09	0.94	0.00	1.00	TRUE
3	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	-5.6	-5.7	1.5e-08	1.00	0.00	1.00	FALSE
16	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	-5.6	-5.6	2.1e-08	1.00	0.00	1.00	FALSE
6	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	5.2	-5.6	2.4e-08	0.89	0.01	0.99	FALSE
8	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	-5.6	-5.6	2.4e-08	1.00	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	-5.6	-5.6	2.4e-08	1.00	0.00	0.98	FALSE
5	GTEx	Brain Cerebellum	RGS19	0.28	0.22	lasso	4	0.18	7.2e-06	-5.6	-5.6	2.6e-08	0.98	0.00	0.99	FALSE
4	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	-5.6	-5.5	3.4e-08	0.95	0.00	0.95	FALSE
19	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	5.2	5.5	3.9e-08	-0.90	0.00	1.00	FALSE
1	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	-5.6	-5.5	4.4e-08	0.95	0.00	1.00	FALSE
14	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	5.2	-5.5	5.0e-08	0.90	0.00	1.00	FALSE
11	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	-5.6	-5.4	5.7e-08	0.98	0.00	1.00	FALSE
7	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	-5.6	-5.4	5.9e-08	0.93	0.00	1.00	FALSE
15	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	-5.6	-5.4	6.4e-08	0.94	0.00	1.00	FALSE
9	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	-5.6	-5.4	7.1e-08	0.96	0.00	1.00	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	RGS19	0.51	0.28	enet	28	0.32	4.3e-18	-5.6	-5.4	7.1e-08	0.87	0.00	1.00	FALSE
20	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	-5.6	5.3	1.1e-07	-0.91	0.00	1.00	FALSE
2	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	-5.6	5.3	1.2e-07	-0.94	0.00	1.00	FALSE
18	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	5.2	-5.2	1.9e-07	0.89	0.00	0.91	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS19	0.06	0.06	blup	47	0.05	1.4e-06	-5.6	-5.2	2.3e-07	0.91	0.00	1.00	FALSE
17	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	5.2	-5.2	2.4e-07	0.89	0.00	1.00	FALSE
10	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	5.2	-5.2	2.5e-07	0.83	0.01	0.99	FALSE