TWAS hub - TCEA2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.106	0.042	0.0078	0.063	NA	0.013	NA	0.033	6.8e-06	NA	0.030	NA	0.00095
2	GTEx	Artery Aorta	0.091	0.038	0.0075	0.044	NA	0.020	NA	0.026	1.8e-03	NA	0.026	NA	0.01300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Cardiovascular Disease	19.2	63.5	79.3	6.9	8.9
Systolic blood pressure, automated reading	15.2	44.1	51.5	6.1	7.2
Vascular/heart problems diagnosed by doctor	13.8	37.7	49.5	-5.1	-7.0
Medication for cholesterol, blood pressure or diabetes	13.6	22.5	28.8	-4.0	-5.4
High cholesterol (Self-reported)	12.7	22.6	30.4	3.8	5.5
Systolic Blood Pressure	12.2	60.8	69.6	7.2	8.3
High blood pressure	11.7	32.5	40.2	5.0	6.3
Medication: Simvastatin	11.5	17.0	28.0	2.4	5.3
Hypertension (Self-reported)	11.2	31.2	36.0	5.1	6.0
Diastolic blood pressure, automated reading	10.9	33.9	39.1	6.3	5.4
Angina	10.7	14.0	20.7	2.7	4.5
Cholesterol lowering medication	10.7	15.8	23.9	2.8	4.9
Angina (self-reported)	10.3	13.5	19.9	2.7	4.5
Had other major operations	9.8	11.9	13.7	-3.7	-3.2
Number of self-reported non-cancer illnesses	9.6	16.6	23.1	3.2	4.8
Medication: Cholesterol lowering	9.3	14.4	23.1	2.4	4.8
Illnesses of father: Heart disease	9.1	12.6	14.2	3.3	3.8
Medication: Blood pressure	9.1	17.3	20.8	3.7	4.6
Diabetes (mother)	8.9	11.3	12.5	3.5	3.2
Waist Hip Ratio (WHR)	7.9	35.5	44.7	5.1	6.7
Breast cancer (self-reported)	7.9	9.4	12.0	-3.5	-2.6
Ulcerative Colitis (UC)	7.3	13.6	14.8	-3.5	-3.8
Medication: Ramipril	7.2	9.2	15.1	1.8	3.9
Medication: Blood pressure	7.0	12.4	12.5	3.5	3.5
Medication for cholesterol	7.0	10.5	17.0	-2.0	-4.1
Medication: Aspirin	6.7	8.8	17.0	0.8	4.1
Medication: Aspirin	6.5	8.5	16.4	0.7	4.1
Rheumatoid Arthritis	6.4	8.9	11.1	-2.6	-3.3
Deep venous thrombosis (DVT) (self-reported)	6.1	7.8	10.3	-3.2	-2.3
Birth weight of first child	5.9	10.7	14.7	-2.6	-3.8
Breast Cancer	5.8	13.9	15.2	3.5	3.9
Illnesses of father: None of the above (group 1)	5.6	6.9	7.1	-2.6	-2.7
Medication: Lisinopril	5.3	6.9	8.2	2.3	2.9
LDL Cholesterol	5.1	8.1	10.8	2.3	3.3
Medication: Bendroflumethiazide	4.9	7.5	9.5	2.3	3.1
Bipolar Disorder (2018)	4.6	7.2	7.6	-2.8	-2.6
Blood clot in the leg (DVT)	4.6	6.0	7.4	-2.7	-2.1
Medication: Atorvastatin	4.6	5.7	7.1	2.1	2.7
Number of live births	4.1	5.8	8.4	1.8	2.9
Illnesses of mother	4.1	5.1	6.1	-2.0	-2.5
Number of operations (self-reported)	4.1	6.1	10.8	-3.3	-1.2
HDL Cholesterol	4.0	6.8	9.7	-2.0	-3.1
Mouth/teeth dental problems: Mouth ulcers	4.0	6.4	9.3	-1.9	-3.0
Medication: Atenolol	3.9	4.9	5.2	2.3	2.1
Back pain experienced in last month	3.9	5.7	5.8	-2.4	-2.4
Heart disease (mother)	3.8	4.6	6.1	1.8	2.5
Lung FVC	3.6	18.2	33.5	-1.7	-5.8
Relative age voice broke	3.4	5.2	6.1	2.1	2.5
Birth weight	3.4	7.4	9.8	-2.3	-3.1
Illnesses of siblings	3.3	4.6	6.8	-1.6	-2.6
Had major operations	3.3	3.8	6.8	-2.6	-1.0
Irritability	3.2	5.4	7.2	-2.7	-1.9
Triglycerides	3.1	5.1	8.3	1.4	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.4	12.7	0.3	-3.6
Body Mass Index (BMI) (2010)	2.9	4.0	7.8	-0.4	-2.8
Myopia	2.9	4.2	5.1	-1.8	-2.3
Irritable Bowel Disease (IBD)	2.8	6.6	6.7	-2.5	-2.6
Stomach or abdominal pain in last month	2.7	3.3	5.5	-2.3	-1.1
Type 2 Diabetes (T2D) (2018)	2.6	4.8	8.8	0.9	3.0
Diabetes diagnosed by doctor	2.6	4.2	8.4	-0.1	2.9
Eye problems/disorders: Glaucoma	2.6	3.1	4.4	2.1	1.3
Reaction Time	2.5	4.7	4.7	2.2	2.2
High blood pressure (siblings)	2.5	3.6	4.8	1.6	2.2
Migraine (self-reported)	2.5	3.1	4.2	2.0	1.4
Handedness (chirality/laterality): Left-handed	2.5	3.0	3.2	-1.7	-1.8
Pain experienced in last month	2.5	4.1	5.7	2.4	1.6
Loud music exposure frequency	2.4	2.6	4.1	-1.0	-2.0
Medication: Paracetamol	2.4	3.8	4.8	-1.7	-2.2
Average weekly fortified wine intake	2.3	2.7	2.9	1.7	1.6
Impedance of leg (right)	2.2	10.6	15.5	2.4	3.9
Hand grip strength (right)	2.2	5.9	7.2	2.7	2.1
Forced vital capacity (FVC)	2.2	8.3	13.6	-1.7	-3.7
Heart attack	2.2	2.9	5.7	-0.2	2.4
Heart attack/myocardial infarction (self-reported)	2.2	2.9	5.6	-0.4	2.4
Intelligence (Savage-Jansen 2018)	2.1	6.3	9.1	-3.0	-1.9
Impedance of leg (left)	2.1	10.0	15.4	2.1	3.9
Mean time to correctly identify matches	2.1	3.9	4.0	2.0	2.0
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.1	-2.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.9	0.2	2.2
Tinnitus: Yes, now most or all of the time	2.0	2.4	4.0	0.8	2.0
Ovarian Cancer	1.8	2.3	3.9	0.9	-2.0
Crohns Disease (2012)	1.8	2.8	4.8	-2.2	-0.9
Pain all over the body in last month	1.8	1.9	2.4	1.6	1.2
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	11.4	-1.0	-3.4
Number of full brothers	1.8	2.2	4.0	-2.0	-0.6
Medication: Gliclazide	1.8	2.0	3.4	0.8	1.9
Hypothyroidism (self reported)	1.7	3.9	5.0	2.2	1.7
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.7	0.0	1.9
Vitamin and mineral supplements	1.6	2.2	2.8	1.7	1.2
Diabetes (self-reported)	1.6	2.5	4.7	-0.5	2.2
Lung cancer (father)	1.6	1.9	2.8	-1.7	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.4	0.3	1.8
Age at First Birth	1.5	2.1	2.7	1.2	1.6
Hand grip strength (left)	1.5	3.9	5.3	2.3	1.6
Severe depression (siblings)	1.5	1.6	3.2	-0.3	1.8
Number of incorrect matches in round	1.5	2.5	3.1	-1.4	-1.8
Long-standing illness, disability or infirmity	1.5	2.2	4.4	-0.1	2.1
Ever taken oral contraceptive pill	1.5	1.7	2.0	1.4	1.1
Relative age of first facial hair	1.4	2.8	3.8	1.4	2.0
Qualifications: CSEs or equivalent	1.4	1.8	2.3	1.2	1.5
High blood pressure (mother)	1.4	1.9	2.6	1.1	1.6
Exposure to tobacco smoke at home	1.4	1.6	2.1	-1.1	-1.4
Forced vital capacity (FVC), Best measure	1.4	5.3	8.6	-1.4	-2.9
Qualifications: nursing, teaching	1.4	2.1	4.2	-2.1	-0.1
Medication: Levothyroxine sodium	1.3	2.2	3.3	1.8	1.0
Hair/balding pattern: Pattern 3	1.3	1.9	2.3	-1.2	-1.5
Peak expiratory flow (PEF)	1.3	3.1	4.8	-1.2	-2.2
Medication: Paracetamol	1.3	2.2	2.9	-1.2	-1.7
Gout (self-reported)	1.3	1.8	2.3	1.5	1.1
Shortness of breath walking on level ground	1.3	1.5	2.4	-0.8	-1.5
Illnesses of father: High blood pressure	1.3	1.6	1.9	1.2	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	6.9	-0.8	-2.6
Leg fat percentage (right)	1.2	4.5	6.0	2.5	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.4	-0.6	-1.6
Supplements: Vitamin C	1.2	1.5	2.9	0.0	1.7
HbA1C	1.1	1.2	1.7	1.3	0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.8	0.8	1.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.2	1.5	0.5
Family relationship satisfaction	1.1	1.3	1.9	0.8	1.4
Loneliness, isolation	1.1	1.5	2.3	0.8	1.5
Impedance of whole body	1.1	5.8	11.1	0.7	3.3
Supplements: Zinc	1.0	1.1	1.6	0.8	1.3
Medication: Metformin	1.0	1.4	2.2	-0.8	1.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.3	-1.1	-0.9
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.6	1.6	1.1
Qualifications: College or University degree	1.0	3.1	4.1	-2.0	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.5	-0.9	-1.2
Leg fat percentage (left)	1.0	3.8	5.0	2.2	1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.3	4.5	-2.1	-0.1
Allergy or Eczema	0.9	2.3	2.4	-1.5	1.6
Hearing difficulty/problems: Yes	0.9	1.4	2.0	-1.4	-0.9
Waist circumference	0.9	3.5	3.8	1.9	1.8
Falls in the last year	0.9	1.2	2.2	0.6	1.5
Happiness	0.9	1.1	1.2	-1.0	-1.1
Length of working week for main job	0.9	1.0	1.9	-0.3	-1.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.7	-1.6	-0.2
Medication for pain relief, constipation, heartburn	0.9	1.6	2.0	-1.1	-1.4
Mood swings	0.9	1.6	3.0	-0.4	1.7
Risk taking	0.9	1.3	2.3	-1.5	-0.6
Schizophrenia (2018)	0.8	1.7	2.1	1.5	1.1
Blood White Count	0.8	5.9	11.4	-0.5	3.4
Qualifications: None of the above	0.8	1.8	3.5	1.9	0.3
Allergy	0.8	1.9	3.8	1.9	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.0	0.7	1.4
Eye problems/disorders: None of the above	0.8	1.0	1.6	1.3	0.6
Ever depressed for a whole week	0.8	1.0	1.9	-0.4	1.4
Heart disease (siblings)	0.8	1.0	1.7	0.5	1.3
Ulcerative Colitis	0.7	1.0	2.0	0.0	-1.4
Medication for hormone replacement therapy	0.7	0.7	1.4	-1.2	-0.3
Serious illness, injury or assault to yourself	0.7	0.9	1.4	0.7	1.2
Hearing difficulty/problems with background noise	0.7	1.1	1.5	-1.2	-0.9
Alcohol intake versus 10 years previously	0.7	1.1	1.8	1.4	0.6
Pulse wave Arterial Stiffness index	0.7	0.8	1.4	0.5	1.2
Neck or shoulder pain in last month	0.7	1.0	1.1	-1.0	-1.1
Illnesses of siblings: Diabetes	0.7	0.9	1.8	0.1	1.3
Leg fat-free mass (right)	0.7	3.8	4.7	-1.7	-2.2
Mineral and other dietary supplements	0.7	0.9	1.1	1.0	0.8
Leg predicted mass (right)	0.7	3.7	4.6	-1.7	-2.1
Unable to work because of sickness or disability	0.7	0.9	1.6	-0.4	1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.0	-0.7	-1.0
Leg fat-free mass (left)	0.6	3.1	4.0	-1.4	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.5	-1.6	-0.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.0	-1.4	0.7
Leg predicted mass (left)	0.6	3.0	4.0	-1.4	-2.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.0	0.8	1.0
Impedance of arm (right)	0.6	2.7	5.3	-0.2	2.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	0.8	-0.8	-0.9
Glaucoma (self-reported)	0.6	0.7	1.2	1.1	-0.5
Medication: Amlodipine	0.6	0.8	1.1	1.0	0.7
Medication: Ibuprofen	0.6	0.7	1.4	1.2	0.2
Chest pain or discomfort	0.6	0.9	1.8	-0.1	1.3
Knee pain experienced in last month	0.6	0.9	1.5	-1.2	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-0.5	1.0
Blood Red Count	0.5	4.9	6.5	2.5	1.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-1.2	-0.1
Current tobacco smoking	0.5	0.7	0.8	0.9	0.8
Maternal smoking around birth	0.5	0.7	1.1	1.1	0.5
Past tobacco smoking	0.5	1.0	1.8	1.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.4	-1.5	-0.1
Financial difficulties in last 2 years	0.5	0.7	0.7	0.9	0.8
Mouth/teeth dental problems	0.5	0.8	1.0	0.8	1.0
Hip circumference	0.5	2.1	3.2	-1.0	-1.8
Time employed in main current job	0.5	0.5	1.1	1.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	-1.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	-1.0	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	1.1	0.2
Impedance of arm (left)	0.5	2.2	3.8	-0.8	1.9
Headache pain in last month	0.5	0.9	1.6	-1.3	-0.4
Medication: Omeprazole	0.5	0.6	0.9	-0.9	-0.5
Medication: Seretide 50 evohaler	0.5	0.5	1.0	-0.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.0	1.0	-0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	0.8	0.7	-0.9
Smoking status: Previous	0.5	0.8	1.6	-1.3	-0.2
Osteoarthritis (self-reported)	0.5	0.7	1.2	1.1	0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.3	1.1	0.2
Miserableness	0.5	0.9	1.5	-0.6	1.2
Alcohol drinker status: Never	0.5	0.6	1.1	0.2	-1.1
Pack years of smoking	0.5	0.7	1.2	1.1	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	0.7	-0.7	-0.8
Mean Putamen Volume	0.4	0.5	1.0	0.2	1.0
Fasting Glucose	0.4	0.5	1.0	0.0	1.0
Blood Eosinophil Count	0.4	2.8	4.9	-0.8	2.2
Nervous feelings	0.4	0.8	1.4	-1.2	-0.4
Had menopause	0.4	0.5	0.9	-1.0	-0.3
Fluid intelligence score	0.4	0.8	1.6	-1.3	-0.1
Prospective memory result	0.4	0.5	1.1	0.2	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.6	0.6	0.8
Body fat percentage	0.4	1.7	1.9	1.2	1.4
Comparative body size at age 10	0.4	1.0	2.0	1.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.0	-1.0	-0.3
Pulse wave peak to peak time	0.4	0.4	0.8	-0.3	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.6	-0.8	0.6
Number of full sisters	0.4	0.5	0.9	-0.2	1.0
Overall health rating	0.4	0.8	1.3	0.6	1.1
Age at last live birth	0.4	0.6	0.6	-0.8	0.7
Whole body fat-free mass	0.4	2.5	3.6	-1.2	-1.9
Ever had bowel cancer screening	0.4	0.5	0.8	-0.9	-0.4
Commuting to job workplace: Walk	0.4	0.4	0.6	0.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.6	0.6	0.8
Smoking status: Current	0.4	0.7	0.8	0.8	0.9
Whole body water mass	0.4	2.5	3.6	-1.2	-1.9
Wears glasses or contact lenses	0.4	0.4	0.7	-0.8	0.4
Financial situation satisfaction	0.4	0.5	0.9	0.4	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.4	-1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.7	-0.6	-0.9
Alcohol drinker status: Previous	0.4	0.5	0.5	0.7	0.7
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	0.6	1.1
Heel T-Score	0.3	2.0	3.2	-1.8	0.9
BMI	0.3	1.8	3.0	0.8	-1.7
Respiratory disease	0.3	0.7	1.5	-0.1	1.2
Lung FEV1/FVC ratio	0.3	1.5	3.1	1.8	-0.0
Number of treatments/medications taken	0.3	0.5	0.9	0.4	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.4	0.7	0.6
Ever had hysterectomy (womb removed)	0.3	0.3	0.4	0.6	0.6
Medication: Co-codamol	0.3	0.4	0.5	0.7	0.5
Diabetes (father)	0.3	0.4	0.6	0.8	-0.5
Pack years adult smoking proportion	0.3	0.4	0.8	0.9	0.2
Trunk fat percentage	0.3	1.1	1.6	0.7	1.3
Multivitamins +/- minerals	0.3	0.3	0.3	-0.6	-0.6
Trunk fat-free mass	0.3	1.8	2.9	-0.9	-1.7
Asthma	0.3	0.6	1.2	0.1	1.1
Depression (self-reported)	0.3	0.3	0.7	-0.8	0.1
Trunk predicted mass	0.3	1.8	2.7	-0.9	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.2	0.9
Medication: Allopurinol	0.3	0.4	0.7	0.9	0.3
Leg fat mass (right)	0.3	1.0	1.6	1.3	0.6
Leg pain on walking	0.3	0.4	0.7	-0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.7	-0.8	-0.7
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.8	-0.1
Asthma (self-reported)	0.3	0.6	1.1	0.3	1.1
Osteoporosis (self-reported)	0.3	0.3	0.5	-0.4	-0.7
Commuting to job workplace: Public transport	0.3	0.3	0.3	0.5	0.6
Ever smoked	0.3	0.5	0.6	-0.6	0.8
Basal metabolic rate	0.3	1.7	2.5	-0.9	-1.6
Supplements: Calcium	0.3	0.4	0.7	-0.1	0.9
Bipolar Disorder or Schizophrenia	0.2	0.5	0.6	-0.7	-0.8
Crohns Disease (2017)	0.2	0.5	0.9	-0.9	-0.3
Prostate Cancer	0.2	0.3	0.5	-0.1	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.0	0.6
Blood Platelet Count	0.2	2.9	5.4	-0.6	2.3
Height	0.2	4.4	8.8	-0.4	3.0
Neuroticism	0.2	0.4	0.5	0.5	0.7
Chronotype (morning person)	0.2	0.5	0.9	0.2	-1.0
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.1	0.8
Fed-up feelings	0.2	0.3	0.6	0.8	-0.2
Sitting height	0.2	1.7	3.0	-1.7	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.1	0.6
Worrier / anxious feelings	0.2	0.4	0.7	-0.3	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.3	0.6	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.3	0.5	0.6
Arm fat-free mass (right)	0.2	1.2	2.1	-0.6	-1.5
Number of children fathered	0.2	0.2	0.4	0.1	0.6
Age at first live birth	0.2	0.4	0.8	-0.9	-0.3
Health satisfaction	0.2	0.3	0.5	-0.7	-0.3
Emphysema/chronic bronchitis	0.2	0.3	0.5	0.7	0.3
Whole body fat mass	0.2	0.7	0.7	0.8	0.8
Arm predicted mass (right)	0.2	1.0	1.9	-0.3	-1.4
Comparative height size at age 10	0.2	1.1	2.0	0.4	1.4
Suffer from ‘nerves’	0.2	0.3	0.7	-0.0	-0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.3	-0.6	-0.5
Average weekly red wine intake	0.2	0.3	0.4	0.3	0.6
Friendships satisfaction	0.2	0.3	0.5	-0.7	-0.1
Hearing aid user	0.2	0.2	0.3	-0.3	0.5
Mother’s age at death	0.2	0.3	0.5	-0.7	-0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.2	0.5	-0.4
Leg fat mass (left)	0.2	0.6	1.1	1.0	0.4
Depression (Nagel 2018)	0.1	0.2	0.3	0.6	0.1
Neuroticism (Nagel 2018)	0.1	0.1	0.2	-0.2	0.4
Worry (Nagel 2018)	0.1	0.3	0.5	-0.7	-0.1
Neuroticism (2016)	0.1	0.1	0.2	0.4	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	0.3
Smoking Status	0.1	0.3	0.5	-0.3	0.7
Hair Pigment	0.1	2.5	4.9	0.4	-2.2
Tanning	0.1	1.3	2.0	1.4	0.8
Average weekly spirits intake	0.1	0.2	0.2	0.5	0.3
Sensitivity / hurt feelings	0.1	0.1	0.2	0.3	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.3	-0.5
Taking other prescription medications	0.1	0.1	0.2	-0.1	0.5
Age when periods started (menarche)	0.1	0.1	0.3	-0.5	0.2
Body mass index (BMI)	0.1	0.5	0.9	0.4	-1.0
Trunk fat mass	0.1	0.5	0.6	0.6	0.8
Alcohol usually taken with meals	0.1	0.2	0.3	0.5	0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.5	0.0
Neuroticism score	0.1	0.2	0.2	-0.5	0.3
Arm fat percentage (right)	0.1	0.6	0.7	0.8	0.7
Medication: Lansoprazole	0.1	0.1	0.1	-0.4	0.1
Standing height	0.1	1.0	1.2	-1.1	0.9
Breastfed as a baby	0.1	0.1	0.2	-0.4	0.3
Tense / ‘highly strung’	0.1	0.2	0.3	-0.6	0.2
Hair/balding pattern: Pattern 4	0.1	0.1	0.2	-0.4	-0.3
Pulse rate, automated reading	0.1	0.2	0.4	0.6	-0.2
Arm fat percentage (left)	0.1	0.2	0.2	0.5	0.4
Arm fat-free mass (left)	0.1	0.4	0.8	-0.4	-0.9
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.5	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	-0.5	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.5	0.0
Arm predicted mass (left)	0.1	0.5	0.9	-0.3	-0.9
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.2	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.0	-0.1	-0.0
Schizophrenia (2014)	0.0	0.1	0.2	0.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.1	0.3
Supplements: Glucosamine	0.0	0.0	0.1	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.0	-0.3
Weight	0.0	0.2	0.3	-0.1	-0.6
Father’s age at death	0.0	0.1	0.1	0.1	-0.3
Pulse rate	0.0	0.0	0.1	0.3	-0.0
Noisy workplace	0.0	0.1	0.1	0.1	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	-0.3	-0.2
Arm fat mass (right)	0.0	0.0	0.0	0.2	-0.1
Pulse wave reflection index	0.0	0.0	0.0	0.2	-0.1
Exposure to tobacco smoke outside home	0.0	0.0	0.0	0.1	0.2
Worry too long after embarrassment	0.0	0.0	0.0	0.1	-0.2
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	-0.4	-0.0
Alcohol intake frequency.	0.0	0.1	0.1	0.2	-0.3
Arm fat mass (left)	0.0	0.0	0.1	0.3	0.0
Guilty feelings	0.0	0.0	0.0	0.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

TCEA2

Models

Trait associations