Best TWAS P=1.99e-10 · Best GWAS P=2.27e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | -6.2 | -6.4 | 2.0e-10 | 0.95 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Liver | CELSR2 | 0.39 | 0.36 | lasso | 1 | 0.35 | 1.0e-10 | -6.2 | -6.2 | 4.9e-10 | 0.97 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | -6.2 | -6.2 | 6.2e-10 | 0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | -6.2 | -6.1 | 1.0e-09 | 0.96 | 0.00 | 1.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CELSR2 | 0.25 | 0.21 | lasso | 6 | 0.23 | 4.9e-29 | -6.2 | -6.0 | 1.9e-09 | 0.94 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SORT1 | 0.23 | 0.16 | lasso | 4 | 0.16 | 4.6e-08 | -6.2 | -6.0 | 2.7e-09 | 0.92 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSRC1 | 0.16 | 0.20 | lasso | 3 | 0.19 | 3.7e-09 | -5.9 | -5.9 | 2.8e-09 | 0.93 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSRC1 | 0.12 | 0.11 | lasso | 4 | 0.09 | 4.5e-06 | -5.8 | -5.8 | 6.2e-09 | 0.95 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSRC1 | 0.07 | 0.06 | lasso | 1 | 0.04 | 1.8e-03 | -5.6 | -5.6 | 2.2e-08 | 0.77 | 0.01 | 0.83 | FALSE |