Hub : Traits :

Medication: Aspirin

25 significantly associated models · 9 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 3 1 2.0e-10 2.3e-10 1.0e+00 100 PSRC1
2 4 52683607 53598975 2 1 1.0e-07 2.2e-07 6.0e-02 87 SGCB
3 6 160071844 161571560 1 1 4.0e-08 3.5e-07 3.9e-06 18 SLC22A3
4 9 21303958 22819407 2 1 2.5e-10 6.1e-17 4.4e-08 57 CDKN2B
5 15 90730363 92135418 1 1 4.1e-09 1.4e-07 8.8e-01 100 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.42 1 0 0.0 0.00 1.0e+00 FES
Bipolar Disorder or Schizophrenia 5.80 1 1 2.2 0.00 1.0e+00 FES
Neuroticism (Nagel 2018) 1.27 1 0 0.0 0.00 1.0e+00 FES
Schizophrenia (2018) 5.69 1 1 2.2 0.00 1.0e+00 FES
Crohns Disease (2017) 1.33 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 1.12 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 3.83 2 0 0.0 0.00 1.0e+00 CDKN2B FES
Ovarian Cancer 1.81 1 0 0.0 0.00 1.0e+00 FES
Body Mass Index (BMI) (2010) 3.20 1 0 0.0 0.00 1.0e+00 SGCB
Coronary Artery Disease (CAD) 29.52 3 2 4.4 0.00 1.0e+00 CDKN2B PSRC1 SLC22A3
Crohns Disease (2012) 1.64 1 0 0.0 0.00 1.0e+00 FES
HDL Cholesterol 2.96 1 0 0.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 98.73 1 1 2.2 0.00 1.0e+00 PSRC1
Schizophrenia (2014) 5.26 1 1 2.2 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) (2012) 4.47 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Platelet Count 1.08 3 0 0.0 0.00 1.0e+00 CDKN2B SGCB SLC22A3
Blood Red Count 0.50 2 0 0.0 0.00 1.0e+00 CDKN2B FES
Blood White Count 2.24 3 1 2.2 0.00 1.0e+00 CDKN2B FES SGCB
Heel T-Score 0.58 1 0 0.0 0.00 1.0e+00 PSRC1
BMI 1.86 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Height 1.68 4 4 8.9 -0.64 3.6e-01 FES PSRC1 SGCB SLC22A3
Waist Hip Ratio (WHR) 3.45 1 1 2.2 0.00 1.0e+00 SLC22A3
Systolic Blood Pressure 13.22 3 1 2.2 0.00 1.0e+00 FES SGCB SLC22A3
Smoking Status 3.37 2 0 0.0 0.00 1.0e+00 FES PSRC1
Allergy or Eczema 2.10 1 0 0.0 0.00 1.0e+00 FES
Cardiovascular Disease 16.80 4 2 4.4 0.99 9.4e-03 FES PSRC1 SGCB SLC22A3
Respiratory disease 2.52 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) (2018) 4.33 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Lung FEV1/FVC ratio 1.27 1 1 2.2 0.00 1.0e+00 PSRC1
Neuroticism 1.03 1 0 0.0 0.00 1.0e+00 FES
Chronotype (morning person) 1.69 1 0 0.0 0.00 1.0e+00 SGCB
Hair Pigment 0.82 2 2 4.4 0.00 1.0e+00 CDKN2B FES
Hand grip strength (left) 1.95 1 0 0.0 0.00 1.0e+00 FES
Number of treatments/medications taken 6.98 3 1 2.2 0.00 1.0e+00 FES PSRC1 SGCB
Sensitivity / hurt feelings 3.56 1 1 2.2 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 3.18 2 0 0.0 0.00 1.0e+00 PSRC1 SGCB
Systolic blood pressure, automated reading 11.90 2 1 2.2 0.00 1.0e+00 FES SGCB
Angina 33.31 4 4 8.9 0.99 1.4e-02 CDKN2B FES PSRC1 SLC22A3
Medication: Metformin 5.45 2 0 0.0 0.00 1.0e+00 CDKN2B SGCB
Impedance of leg (right) 2.04 1 1 2.2 0.00 1.0e+00 FES
Leg fat-free mass (left) 2.52 4 0 0.0 -0.57 4.3e-01 FES PSRC1 SGCB SLC22A3
Trunk fat percentage 2.46 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Current tobacco smoking 2.31 1 0 0.0 0.00 1.0e+00 FES
High blood pressure 13.10 1 1 2.2 0.00 1.0e+00 FES
Hayfever, allergic rhinitis or eczema 2.01 1 0 0.0 0.00 1.0e+00 FES
Medication: Atenolol 13.66 3 1 2.2 0.00 1.0e+00 CDKN2B FES PSRC1
Sitting height 1.08 2 0 0.0 0.00 1.0e+00 FES SLC22A3
High blood pressure (mother) 13.86 1 1 2.2 0.00 1.0e+00 FES
Body mass index (BMI) 1.27 1 0 0.0 0.00 1.0e+00 SGCB
Impedance of leg (left) 1.89 1 1 2.2 0.00 1.0e+00 FES
Leg predicted mass (left) 2.55 4 0 0.0 -0.57 4.3e-01 FES PSRC1 SGCB SLC22A3
Trunk fat mass 2.86 2 1 2.2 0.00 1.0e+00 SGCB SLC22A3
Waist circumference 1.66 1 0 0.0 0.00 1.0e+00 SGCB
Number of incorrect matches in round 3.27 1 0 0.0 0.00 1.0e+00 FES
Past tobacco smoking 2.03 1 0 0.0 0.00 1.0e+00 FES
Alcohol usually taken with meals 2.95 1 0 0.0 0.00 1.0e+00 FES
Mouth/teeth dental problems 1.76 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack 26.03 4 4 8.9 1.00 2.7e-03 CDKN2B FES PSRC1 SLC22A3
Allergy 2.29 1 0 0.0 0.00 1.0e+00 FES
Diabetes (self-reported) 3.76 1 0 0.0 0.00 1.0e+00 SGCB
Medication: Ramipril 7.78 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Medication: Simvastatin 31.22 5 2 4.4 0.95 1.2e-02 CDKN2B FES PSRC1 SGCB SLC22A3
Illnesses of siblings 7.20 2 1 2.2 0.00 1.0e+00 FES SGCB
Weight 2.54 2 1 2.2 0.00 1.0e+00 SGCB SLC22A3
Impedance of arm (right) 1.06 2 0 0.0 0.00 1.0e+00 CDKN2B PSRC1
Arm fat percentage (right) 2.16 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Trunk fat-free mass 2.48 4 1 2.2 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Hip circumference 2.34 2 1 2.2 0.00 1.0e+00 SGCB SLC22A3
Alcohol intake versus 10 years previously 2.52 1 0 0.0 0.00 1.0e+00 SGCB
Father's age at death 12.06 4 1 2.2 -1.00 4.5e-03 CDKN2B FES PSRC1 SGCB
Number of live births 1.60 1 0 0.0 0.00 1.0e+00 FES
Asthma 1.49 1 0 0.0 0.00 1.0e+00 FES
Medication: Ibuprofen (e.g. Nurofen) 2.21 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication: Cholesterol lowering 42.87 5 2 4.4 0.94 1.9e-02 CDKN2B FES PSRC1 SGCB SLC22A3
Lung cancer (father) 4.32 1 0 0.0 0.00 1.0e+00 FES
Illnesses of mother 9.85 2 1 2.2 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 4.26 1 0 0.0 0.00 1.0e+00 FES
Impedance of arm (left) 0.87 1 0 0.0 0.00 1.0e+00 PSRC1
Arm fat mass (right) 2.54 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Trunk predicted mass 2.47 4 1 2.2 -0.57 4.3e-01 FES PSRC1 SGCB SLC22A3
Standing height 1.45 3 1 2.2 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Breastfed as a baby 3.50 1 0 0.0 0.00 1.0e+00 FES
Hair/balding pattern: Pattern 4 2.08 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 7.17 1 1 2.2 0.00 1.0e+00 FES
Headache pain in last month 3.09 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol, blood pressure or diabetes 21.73 2 2 4.4 0.00 1.0e+00 FES PSRC1
Glaucoma (self-reported) 8.60 1 1 2.2 0.00 1.0e+00 CDKN2B
Medication: Amlodipine 6.71 1 1 2.2 0.00 1.0e+00 FES
Birth weight 4.19 1 1 2.2 0.00 1.0e+00 FES
High blood pressure (siblings) 8.22 2 1 2.2 0.00 1.0e+00 FES SGCB
Body fat percentage 2.15 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Leg fat percentage (right) 1.33 1 0 0.0 0.00 1.0e+00 SGCB
Arm fat-free mass (right) 2.24 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Pulse wave peak to peak time 4.53 1 0 0.0 0.00 1.0e+00 FES
Medication for pain relief, constipation, heartburn 3.12 1 0 0.0 0.00 1.0e+00 PSRC1
Medication: Blood pressure 12.10 1 1 2.2 0.00 1.0e+00 FES
Angina (self-reported) 35.04 4 4 8.9 0.99 9.3e-03 CDKN2B FES PSRC1 SLC22A3
Medication: Ibuprofen 2.92 1 0 0.0 0.00 1.0e+00 SLC22A3
Mean time to correctly identify matches 2.07 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 15.18 3 2 4.4 0.00 1.0e+00 CDKN2B FES SLC22A3
Whole body fat mass 2.71 2 1 2.2 0.00 1.0e+00 SGCB SLC22A3
Leg fat mass (right) 2.08 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Arm predicted mass (right) 2.41 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Comparative height size at age 10 2.07 4 0 0.0 -0.67 3.3e-01 FES PSRC1 SGCB SLC22A3
Chest pain or discomfort 4.36 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 26.52 5 5 11.1 1.00 5.3e-08 CDKN2B FES PSRC1 SGCB SLC22A3
Hypertension (Self-reported) 13.67 2 1 2.2 0.00 1.0e+00 FES SLC22A3
Illnesses of father: Heart disease 35.00 4 4 8.9 1.00 2.6e-03 CDKN2B FES PSRC1 SLC22A3
Whole body fat-free mass 2.47 4 0 0.0 -0.59 4.1e-01 FES PSRC1 SGCB SLC22A3
Leg fat-free mass (right) 2.58 4 0 0.0 -0.62 3.8e-01 FES PSRC1 SGCB SLC22A3
Arm fat percentage (left) 1.97 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Handedness (chirality/laterality): Left-handed 2.49 1 0 0.0 0.00 1.0e+00 FES
Long-standing illness, disability or infirmity 3.25 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 4.20 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Medication for cholesterol 12.63 3 1 2.2 0.00 1.0e+00 FES PSRC1 SLC22A3
Mineral and other dietary supplements 3.30 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Breast cancer (self-reported) 2.51 1 0 0.0 0.00 1.0e+00 CDKN2B
Asthma (self-reported) 1.50 1 0 0.0 0.00 1.0e+00 FES
Medication: Gliclazide 2.61 1 0 0.0 0.00 1.0e+00 CDKN2B
Illnesses of father: None of the above (group 1) 16.37 3 2 4.4 0.00 1.0e+00 CDKN2B FES SLC22A3
Whole body water mass 2.41 4 0 0.0 -0.59 4.1e-01 FES PSRC1 SGCB SLC22A3
Leg predicted mass (right) 2.60 4 0 0.0 -0.62 3.8e-01 FES PSRC1 SGCB SLC22A3
Arm fat mass (left) 2.49 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Eye problems/disorders: Glaucoma 11.87 1 1 2.2 0.00 1.0e+00 CDKN2B
Medication: Blood pressure 12.20 2 1 2.2 0.00 1.0e+00 FES SLC22A3
Supplements: Fish oil (including cod liver oil) 3.63 2 0 0.0 0.00 1.0e+00 FES SLC22A3
High cholesterol (Self-reported) 47.87 3 2 4.4 0.00 1.0e+00 FES PSRC1 SLC22A3
Medication: Bendroflumethiazide 4.93 1 1 2.2 0.00 1.0e+00 FES
Medication: Lisinopril 3.06 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 29.22 3 2 4.4 0.00 1.0e+00 CDKN2B PSRC1 SLC22A3
Illnesses of father: High blood pressure 9.69 1 1 2.2 0.00 1.0e+00 FES
Ever smoked 1.85 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 2.49 4 0 0.0 -0.52 4.8e-01 FES PSRC1 SGCB SLC22A3
Leg fat percentage (left) 1.15 1 0 0.0 0.00 1.0e+00 SGCB
Arm fat-free mass (left) 2.18 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Risk taking 2.90 1 0 0.0 0.00 1.0e+00 FES
Age started oral contraceptive pill 2.37 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 9.70 2 1 2.2 0.00 1.0e+00 CDKN2B FES
Vascular/heart problems diagnosed by doctor 16.45 3 1 2.2 0.00 1.0e+00 CDKN2B FES SLC22A3
Cholesterol lowering medication 26.97 4 2 4.4 0.98 2.5e-02 CDKN2B PSRC1 SGCB SLC22A3
Basal cell carcinoma (self-reported) 4.01 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 26.24 4 4 8.9 1.00 3.1e-03 CDKN2B FES PSRC1 SLC22A3
Heart disease (siblings) 12.48 4 0 0.0 0.97 3.0e-02 CDKN2B FES PSRC1 SLC22A3
Impedance of whole body 1.25 2 0 0.0 0.00 1.0e+00 FES PSRC1
Leg fat mass (left) 2.03 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Arm predicted mass (left) 2.36 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 1 0.049 1.3
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 1 0.027 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 1 0.051 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 1 0.030 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 1 0.139 1.3
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 1 0.035 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 1 0.050 1.4
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.3
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 4 0.074 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.181 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3