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chr4:9,370,814-11,156,010

Best TWAS P=2.84e-56 · Best GWAS P=4.18e-69 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	WDR1	0.04	0.01	enet	10	0.03	3.8e-04	-11.5	5.9	3.3e-09	-0.02	0.27	0.02	FALSE
2	GTEx	Adipose Subcutaneous	SLC2A9	0.06	0.06	lasso	2	0.04	6.1e-04	-11.4	11.3	1.3e-29	-0.34	0.42	0.06	FALSE
3	GTEx	Adipose Subcutaneous	RP11-448G15.3	0.08	0.06	lasso	4	0.07	3.8e-06	6.5	5.8	4.8e-09	-0.37	0.69	0.02	TRUE
4	GTEx	Adipose Visceral Omentum	SLC2A9	0.15	0.02	lasso	4	0.04	3.6e-03	10.5	8.7	2.8e-18	-0.11	0.31	0.06	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-448G15.3	0.10	0.02	lasso	6	0.03	9.6e-03	-17.1	15.8	2.8e-56	-0.61	0.10	0.17	TRUE
6	GTEx	Adrenal Gland	RP11-448G15.3	0.10	0.07	enet	10	0.05	9.2e-03	6.5	9.4	7.6e-21	-0.55	0.14	0.33	FALSE
7	GTEx	Artery Aorta	SLC2A9	0.06	0.08	enet	4	0.08	3.7e-05	5.6	6.0	2.1e-09	-0.39	0.86	0.01	FALSE
8	GTEx	Artery Aorta	RP11-448G15.3	0.11	0.10	lasso	4	0.07	6.6e-05	6.5	5.2	2.5e-07	-0.32	0.88	0.01	FALSE
9	GTEx	Artery Coronary	SLC2A9	0.11	0.11	enet	4	0.08	8.6e-04	4.6	7.9	2.6e-15	-0.30	0.42	0.06	FALSE
10	GTEx	Artery Tibial	WDR1	0.19	0.06	enet	26	0.10	1.6e-08	5.7	7.6	3.2e-14	-0.42	0.99	0.00	FALSE
11	GTEx	Artery Tibial	SLC2A9	0.25	0.29	lasso	6	0.27	4.2e-21	6.5	7.0	3.1e-12	-0.39	1.00	0.00	FALSE
12	GTEx	Artery Tibial	ZNF518B	0.06	0.07	lasso	4	0.04	2.2e-04	5.9	5.9	4.4e-09	-0.24	0.94	0.00	FALSE
13	GTEx	Artery Tibial	RP11-448G15.3	0.22	0.11	enet	25	0.16	8.7e-13	6.5	7.8	9.3e-15	-0.35	0.98	0.00	FALSE
14	GTEx	Breast Mammary Tissue	RP11-448G15.3	0.18	0.01	lasso	10	0.07	2.2e-04	-13.5	12.0	3.4e-33	-0.69	0.42	0.21	FALSE
15	GTEx	Cells Transformed fibroblasts	RP11-448G15.3	0.07	0.03	lasso	3	0.03	3.8e-03	5.7	6.4	1.2e-10	-0.32	0.75	0.01	FALSE
16	GTEx	Colon Sigmoid	SLC2A9	0.26	0.11	lasso	13	0.15	5.9e-06	4.6	6.5	1.1e-10	-0.30	0.68	0.04	FALSE
17	GTEx	Colon Transverse	SLC2A9	0.08	0.04	lasso	1	0.01	7.7e-02	5.9	5.9	3.9e-09	-0.35	0.19	0.04	TRUE
18	GTEx	Colon Transverse	RP11-448G15.3	0.12	0.00	lasso	6	0.00	6.5e-01	6.7	5.4	5.9e-08	-0.11	0.20	0.04	FALSE
19	GTEx	Esophagus Mucosa	RP11-448G15.3	0.07	0.01	enet	10	0.02	1.2e-02	-2.8	9.4	7.0e-21	-0.28	0.37	0.06	TRUE
20	GTEx	Esophagus Muscularis	SLC2A9	0.19	0.14	lasso	6	0.22	1.2e-13	4.8	7.3	2.0e-13	-0.33	1.00	0.00	FALSE
21	GTEx	Esophagus Muscularis	RP11-448G15.3	0.11	0.00	enet	14	0.03	1.1e-02	-3.1	8.7	4.4e-18	-0.32	0.25	0.06	FALSE
22	GTEx	Liver	SLC2A9	0.18	0.13	lasso	6	0.12	3.7e-04	5.8	7.4	1.5e-13	-0.01	0.34	0.04	TRUE
23	GTEx	Nerve Tibial	WDR1	0.12	0.02	lasso	5	0.03	1.8e-03	7.4	10.4	2.0e-25	-0.41	0.32	0.18	TRUE
24	GTEx	Nerve Tibial	RP11-448G15.3	0.22	0.10	enet	27	0.23	2.6e-16	6.5	9.7	2.0e-22	-0.38	1.00	0.00	FALSE
25	GTEx	Skin Sun Exposed Lower leg	SLC2A9	0.18	0.03	enet	15	0.06	1.2e-05	11.1	11.4	5.5e-30	-0.30	0.56	0.07	FALSE
26	GTEx	Thyroid	RP11-448G15.3	0.17	0.05	enet	40	0.12	1.3e-09	6.5	6.0	2.8e-09	-0.24	0.90	0.00	TRUE
27	GTEx	Whole Blood	SLC2A9	0.11	0.04	lasso	6	0.05	9.9e-06	4.9	6.0	1.8e-09	-0.37	0.92	0.00	FALSE
28	METSIM	Adipose	SLC2A9	0.05	0.04	lasso	4	0.03	9.3e-06	10.5	9.8	1.4e-22	-0.19	1.00	0.00	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	RP11-448G15.3	0.06	0.04	blup	552	0.05	7.9e-07	6.5	10.9	6.9e-28	-0.55	0.96	0.04	TRUE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR1	0.04	0.02	lasso	5	0.03	1.7e-06	-8.0	-5.8	8.6e-09	0.00	0.98	0.00	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZNF518B	0.08	0.04	lasso	2	0.01	1.2e-01	-6.5	-6.6	3.6e-11	0.22	0.02	0.11	FALSE
32	The Cancer Genome Atlas	Esophageal Carcinoma	SLC2A9	0.16	0.02	enet	20	0.05	1.4e-02	5.8	5.7	1.2e-08	-0.16	0.04	0.05	TRUE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF518B	0.09	0.01	enet	8	0.04	2.7e-05	-6.5	-6.2	5.2e-10	0.12	0.27	0.04	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC2A9	0.11	0.06	lasso	2	0.05	3.9e-04	4.8	-5.3	1.2e-07	0.28	0.55	0.07	TRUE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	WDR1	0.06	0.03	blup	111	0.01	3.2e-02	5.5	-7.2	5.0e-13	0.30	0.02	0.57	FALSE