Best TWAS P=8.85e-117 · Best GWAS P=5.74e-174 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PKD2 | 0.17 | 0.10 | enet | 15 | 0.16 | 2.1e-18 | -6.13 | -5.6 | 2.1e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | NUDT9 | 0.28 | 0.00 | enet | 29 | 0.19 | 1.1e-05 | -0.98 | -5.8 | 8.7e-09 | -0.18 | 0.06 | 0.25 | TRUE |
| 3 | GTEx | Testis | PKD2 | 0.45 | 0.48 | lasso | 6 | 0.47 | 2.1e-23 | -5.82 | -6.0 | 2.2e-09 | -0.20 | 1.00 | 0.00 | TRUE |
| 4 | METSIM | Adipose | ABCG2 | 0.05 | 0.01 | bslmm | 512 | 0.01 | 2.9e-03 | -5.42 | 9.8 | 1.5e-22 | 0.24 | 0.17 | 0.04 | TRUE |
| 5 | NTR | Blood | PPM1K | 0.02 | 0.00 | blup | 468 | 0.00 | 1.8e-02 | 5.78 | -10.6 | 4.0e-26 | -0.43 | 0.06 | 0.39 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PKD2 | 0.11 | 0.09 | lasso | 13 | 0.11 | 3.3e-14 | 4.97 | 5.4 | 5.6e-08 | 0.20 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPM1K | 0.04 | 0.05 | lasso | 3 | 0.04 | 5.4e-09 | -5.37 | -5.7 | 1.6e-08 | -0.10 | 1.00 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SPP1 | 0.04 | 0.00 | enet | 11 | 0.01 | 3.3e-03 | -4.46 | -8.3 | 7.4e-17 | -0.28 | 0.04 | 0.51 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABCG2 | 0.04 | 0.02 | blup | 100 | 0.04 | 1.8e-05 | 15.49 | 23.0 | 8.8e-117 | 0.53 | 0.23 | 0.50 | TRUE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PKD2 | 0.07 | 0.01 | blup | 84 | 0.02 | 2.0e-03 | 18.68 | -15.4 | 9.0e-54 | -0.43 | 0.07 | 0.17 | FALSE |
| 11 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PPM1K | 0.08 | 0.03 | blup | 57 | 0.05 | 2.8e-03 | -5.22 | -6.8 | 9.6e-12 | -0.13 | 0.36 | 0.07 | TRUE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABCG2 | 0.11 | 0.03 | lasso | 4 | 0.05 | 2.6e-04 | 8.41 | 8.3 | 1.5e-16 | 0.13 | 0.27 | 0.04 | TRUE |
| 13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SPP1 | 0.14 | 0.03 | blup | 64 | 0.07 | 1.0e-03 | 5.66 | 5.6 | 2.1e-08 | 0.18 | 0.04 | 0.04 | TRUE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HERC6 | 0.04 | 0.00 | blup | 46 | 0.00 | 2.9e-01 | 5.25 | -6.7 | 2.8e-11 | -0.08 | 0.01 | 0.10 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPM1K | 0.13 | 0.11 | enet | 6 | 0.14 | 8.8e-15 | -6.37 | -7.0 | 2.4e-12 | -0.09 | 1.00 | 0.00 | TRUE |