TWAS hub - ZNF518B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0581	0.0248	7.0e-04	0.066	NA	0.027	NA	0.044	6.7e-06	NA	3.2e-03	NA	2.3e-04
2	GTEx	Esophagus Muscularis	0.0790	0.0400	4.9e-03	0.005	NA	0.012	NA	-0.003	1.5e-01	NA	6.2e-02	NA	5.8e-01
3	GTEx	Heart Atrial Appendage	0.1030	0.0470	9.1e-03	0.011	NA	-0.006	NA	-0.003	1.0e-01	NA	1.0e+00	NA	4.6e-01
4	YFS	Blood	0.1116	0.0276	3.1e-11	0.047	0.040	0.043	0.038	0.042	3.8e-15	4.6e-13	5.6e-14	1.3e-12	1.4e-13
5	TCGA	Cervical Squamous Cell Carcinoma	0.0760	0.0410	8.5e-03	0.036	0.006	-0.006	NA	0.008	7.3e-03	1.6e-01	9.3e-01	NA	1.3e-01
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0910	0.0431	1.6e-04	0.011	0.024	0.039	NA	0.022	1.9e-02	8.5e-04	2.7e-05	NA	1.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Medication: Allopurinol	16.3	21.7	43.8	5.9	-2.2	-2.9	-6.6	-6.2
Gout (self-reported)	15.6	21.4	47.9	6.9	0.1	-1.9	-6.5	-5.9
Qualifications: CSEs or equivalent	3.0	4.0	9.1	-3.0	-2.3	-2.7	0.5	-1.4
Alzheimer’s Disease (in mother)	2.1	2.5	5.3	-2.1	0.4	0.1	2.3	2.2
Ever had hysterectomy (womb removed)	2.1	2.3	5.2	1.9	-0.1	-0.0	-2.3	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	8.8	0.8	2.2	3.0	-0.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	7.9	0.2	2.8	2.5	-0.3	0.2
Medication: Omeprazole	2.0	2.4	5.6	-0.5	2.4	2.2	0.7	1.9
Had other major operations	1.9	2.3	5.6	2.4	-1.5	-0.1	-1.2	-2.2
Comparative height size at age 10	1.9	10.5	26.9	1.9	5.2	3.0	3.7	3.1
Pain type(s) experienced in last month: Hip pain	1.9	2.3	7.8	-2.8	0.1	-0.4	2.3	0.7
Tinnitus: Yes, now most or all of the time	1.8	2.1	7.3	2.7	-0.5	0.6	-1.9	-1.0
Basal cell carcinoma (self-reported)	1.8	2.2	6.5	0.6	-1.0	-1.3	-2.5	-1.8
Severe depression (siblings)	1.7	1.9	4.3	-0.5	-1.8	-0.8	-2.1	-1.8
Maternal smoking around birth	1.7	2.4	5.5	0.5	-1.8	-1.1	-2.1	-2.3
Fluid intelligence score	1.7	3.4	8.7	-1.2	1.4	0.2	3.0	2.9
Number of treatments/medications taken	1.6	2.8	6.4	2.4	-0.0	-1.1	-1.9	-2.5
Number of live births	1.6	2.3	7.2	0.4	-0.8	-1.2	-2.1	-2.7
Lung cancer (father)	1.6	1.9	6.8	-2.6	2.0	-0.0	0.9	-0.0
Shortness of breath walking on level ground	1.6	1.9	4.7	1.5	2.2	1.7	-0.1	-1.3
Age at last live birth	1.6	2.3	8.6	-0.9	-0.1	0.4	2.1	2.9
Major Depression (MDD)	1.5	1.8	5.9	-2.4	-1.3	0.5	1.1	1.4
Mother’s age at death	1.5	1.8	5.0	1.9	1.4	2.2	-0.7	-0.3
Average weekly spirits intake	1.4	1.7	6.0	-0.2	-0.5	-1.3	-1.5	-2.4
Pulse wave peak to peak time	1.4	1.7	7.3	2.7	0.9	0.6	1.2	0.2
Alzheimer’s Disease (including proxy)	1.3	1.9	5.1	-1.4	-0.4	-0.3	2.0	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.3	-0.1	2.1	1.6	-1.6	-0.9
Age when periods started (menarche)	1.3	3.2	6.6	0.6	-2.3	-2.6	-1.9	-1.8
Medication: Levothyroxine sodium	1.3	2.3	4.6	-2.1	1.9	-1.1	2.1	0.2
Pulse wave reflection index	1.3	1.7	9.3	-3.0	-0.3	-0.7	0.0	0.3
Exposure to tobacco smoke outside home	1.3	1.7	3.7	1.9	1.7	0.9	-0.7	-1.4
Comparative body size at age 10	1.3	3.6	6.2	-1.2	-2.3	-1.7	-2.5	-2.4
Emphysema/chronic bronchitis	1.3	1.5	4.6	1.0	0.0	-0.2	-1.8	-2.1
Average weekly red wine intake	1.3	1.9	7.1	-0.7	-0.4	0.8	1.7	2.7
Friendships satisfaction	1.3	1.6	4.0	-2.0	-1.1	-1.0	1.1	1.5
Relative age of first facial hair	1.2	2.5	5.7	1.2	-2.4	-1.7	-1.5	-1.7
Falls in the last year	1.2	1.6	6.2	-2.5	0.9	0.1	1.5	0.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.8	-0.3	1.9	2.0	0.4	1.1
Heart disease (mother)	1.2	1.5	5.5	0.1	-0.6	0.8	-2.3	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.9	-2.0	-1.1	-1.9	0.5	-0.0
Ever depressed for a whole week	1.2	1.5	4.5	-2.1	-0.2	-1.1	-1.2	-1.4
Reaction Time	1.1	2.2	5.1	-1.6	-1.3	-2.3	-1.0	-1.6
Rheumatoid Arthritis	1.1	1.5	6.2	-1.4	-0.4	0.2	-2.5	-0.9
Allergy or Eczema	1.1	3.0	7.1	-0.3	1.6	2.0	2.0	2.7
High blood pressure (mother)	1.1	1.6	3.4	1.5	-0.2	-1.6	-1.1	-1.8
Had menopause	1.1	1.3	5.3	2.3	0.8	1.3	-0.6	0.3
Father’s age at death	1.1	1.5	3.4	0.4	0.9	1.9	1.1	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	6.2	0.3	-0.9	-2.5	0.6	0.0
Medication: Lansoprazole	1.1	1.3	3.1	0.4	0.5	1.5	-1.8	-1.4
Pulse wave Arterial Stiffness index	1.1	1.3	5.8	-2.4	-0.7	-0.7	-1.1	-0.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.9	-0.6	-1.4	-0.8	1.9	2.0
Unable to work because of sickness or disability	1.1	1.5	6.1	-2.5	-0.6	-1.1	-0.6	-0.8
Intelligence (Savage-Jansen 2018)	1.0	3.0	9.2	-1.5	-0.6	-0.2	3.0	2.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.4	-2.1	0.6	0.3	0.8	1.0
Stomach or abdominal pain in last month	1.0	1.2	4.7	-0.1	2.2	1.2	1.1	-0.1
Financial difficulties in last 2 years	1.0	1.3	2.1	-1.5	-0.9	-1.4	-1.0	-1.4
Pulse rate	1.0	1.7	4.1	-1.3	0.9	1.8	0.3	2.0
Health satisfaction	1.0	1.2	4.7	-0.1	-0.3	-2.2	-0.8	-1.5
Chest pain or discomfort	1.0	1.4	3.2	1.8	0.1	-1.1	-1.1	-1.7
Loneliness, isolation	1.0	1.4	2.1	-1.4	-0.8	-1.5	-1.2	-1.3
Back pain experienced in last month	1.0	1.4	4.7	-0.8	1.5	0.7	2.2	0.8
Cholesterol lowering medication	1.0	1.4	4.0	0.4	-0.7	-2.0	-0.6	-1.9
Depression (Nagel 2018)	0.9	1.4	4.1	0.1	1.6	0.3	-1.2	-2.0
HDL Cholesterol	0.9	1.4	5.5	-0.4	-2.3	-1.2	0.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.5	1.9	0.1	-1.3	-0.1	-0.9
Hayfever, allergic rhinitis or eczema	0.9	2.0	6.5	-0.2	0.4	1.3	2.0	2.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	4.2	0.6	0.8	0.1	-2.1	-1.9
Hair/balding pattern: Pattern 2	0.9	1.2	4.0	0.2	2.0	1.2	-1.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.4	-1.3	1.3	-0.2	-0.9	-1.6
Worrier / anxious feelings	0.9	1.7	5.8	2.4	2.0	0.4	0.4	0.1
Noisy workplace	0.9	1.1	3.0	-1.4	-0.1	-0.5	-1.1	-1.7
Ever highly irritable/argumentative for 2 days	0.9	1.0	4.5	-2.1	-0.0	-0.8	-0.6	-0.9
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.3	0.1	1.7	1.8	-0.4	-0.5
Age at first live birth	0.9	1.6	4.2	1.5	0.6	1.4	0.9	2.1
Leg pain on walking	0.9	1.1	3.7	-0.2	-0.3	-1.9	0.3	-1.7
Diabetes diagnosed by doctor	0.9	1.4	6.4	-0.8	-0.6	-2.5	0.3	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.3	0.2	1.8	1.6	-0.1	0.9
Alcohol drinker status: Previous	0.9	1.0	2.8	-1.6	1.7	-0.4	0.8	0.0
Schizophrenia vs Biploar Disorder	0.8	1.1	3.2	1.0	0.7	1.8	0.4	1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.3	-1.6	-0.3	-0.4	2.1	2.1
Age at First Birth	0.8	1.1	2.0	1.3	0.2	1.3	1.2	1.4
Height	0.8	15.5	38.6	1.5	6.2	0.9	6.2	3.6
Lung FVC	0.8	4.1	9.1	-2.1	-3.0	-2.7	1.6	1.1
Hand grip strength (left)	0.8	2.1	5.5	1.7	2.3	2.0	-0.4	-0.3
Diabetes (self-reported)	0.8	1.2	3.4	-1.5	-0.4	-1.9	1.3	0.2
Number of full sisters	0.8	1.0	2.9	-1.7	-0.7	-0.8	-1.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.5	-0.0	1.1	1.6	0.1	1.3
Mood swings	0.8	1.5	4.4	-1.8	-0.4	-2.1	0.6	-1.0
Hearing aid user	0.8	0.9	3.4	0.3	1.3	1.9	-0.5	0.2
Number of operations (self-reported)	0.8	1.2	3.3	1.4	0.6	1.8	-0.2	-1.3
Average weekly beer plus cider intake	0.8	1.2	4.2	-1.6	2.0	0.6	-0.6	0.2
Irritability	0.8	1.3	3.2	-1.4	1.4	1.8	-0.7	-0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	4.0	0.2	-2.0	0.1	-1.1	-0.4
Crohns Disease (2012)	0.7	1.2	3.1	0.8	1.8	0.7	1.5	0.8
Medication: Co-codamol	0.7	0.9	2.8	0.4	0.2	0.6	-1.4	-1.7
Current tobacco smoking	0.7	1.1	3.8	-0.5	-1.5	-2.0	-0.1	-0.6
Alcohol usually taken with meals	0.7	1.2	3.1	0.5	-0.6	1.2	1.4	1.7
Nervous feelings	0.7	1.2	3.5	1.1	0.4	-1.6	-0.3	-1.9
Happiness	0.7	0.8	1.4	1.1	1.2	-0.7	1.1	0.6
Illnesses of mother	0.7	0.8	1.5	-1.2	-0.0	-0.8	1.1	1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.0	-1.1	1.3	0.7	1.4	1.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.9	0.1	1.1	1.7	0.7	0.3
Medication: Ibuprofen	0.7	0.8	2.1	1.4	1.3	0.5	0.8	0.4
Illnesses of father: Heart disease	0.7	1.0	1.9	-1.2	-0.7	-1.3	0.7	-1.4
Long-standing illness, disability or infirmity	0.7	1.1	4.1	-0.9	2.0	0.8	-0.7	-0.4
Breast Cancer	0.6	1.3	5.4	-2.3	-0.3	-1.2	-0.0	-1.0
Bipolar Disorder (2011)	0.6	0.6	2.7	1.7	0.8	0.1	0.6	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.6	0.6	1.0	1.2	-1.3	-0.8
Mean Putamen Volume	0.6	0.7	2.6	-0.8	-0.1	-0.9	1.6	0.5
Neuroticism (2016)	0.6	0.9	4.3	-2.1	-0.1	0.2	1.0	0.4
BMI	0.6	3.2	6.1	-2.3	1.2	1.0	-2.5	-2.3
Hypothyroidism (self reported)	0.6	1.3	3.6	-1.9	1.6	-0.1	1.2	0.4
Supplements: Zinc	0.6	0.7	2.7	-0.3	0.8	1.6	-0.4	0.9
Pack years adult smoking proportion	0.6	1.0	3.0	-0.5	0.1	-1.3	-0.9	-1.7
Relative age voice broke	0.6	0.9	1.7	-0.1	-1.0	-1.2	-1.3	-1.1
Taking other prescription medications	0.6	0.9	3.0	1.7	0.0	-0.3	-1.2	-0.8
Multivitamins +/- minerals	0.6	0.8	1.8	-0.8	0.7	1.1	1.3	0.7
Medication: Atenolol	0.6	0.7	2.3	-0.3	-0.5	-1.5	0.3	-1.2
Qualifications: None of the above	0.6	1.3	6.0	0.6	2.5	1.3	0.3	-0.0
Heart attack	0.6	0.7	1.8	-1.4	0.8	0.8	-0.6	-0.9
Time employed in main current job	0.6	0.7	2.0	1.4	-0.6	-0.1	-1.2	-0.5
Standing height	0.6	5.5	14.7	2.5	3.8	-0.2	3.1	1.5
Breastfed as a baby	0.6	0.7	1.5	-0.4	0.6	1.2	1.2	0.9
Birth weight of first child	0.6	1.1	3.8	-1.9	-0.6	-0.3	1.4	0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	3.2	-1.8	1.1	-0.9	1.5	0.4
Number of full brothers	0.6	0.7	3.7	-1.9	-0.7	0.3	-0.3	0.1
Wheeze or whistling in the chest in last year	0.6	1.1	3.0	1.4	1.7	1.1	0.5	0.5
Qualifications: College or University degree	0.6	1.8	5.8	1.0	0.2	2.4	0.9	1.7
Medication: Blood pressure	0.6	1.1	3.0	0.8	-0.4	-0.4	-1.7	-1.7
Migraine (self-reported)	0.6	0.8	2.7	-1.3	0.2	-0.2	0.0	1.6
Family relationship satisfaction	0.6	0.7	1.9	-1.4	1.1	0.8	0.1	0.6
Breast cancer (self-reported)	0.6	0.7	2.2	0.1	0.9	1.5	1.0	0.7
Osteoarthritis (self-reported)	0.6	0.8	3.8	-1.9	-0.2	0.1	-1.0	-0.5
Smoking status: Current	0.6	0.9	3.3	-0.4	-1.3	-1.8	0.0	-0.4
Ever smoked	0.6	1.0	4.6	-2.1	0.5	0.1	0.3	1.1
Myopia	0.6	0.8	4.3	0.6	-0.5	0.0	0.4	2.1
Pack years of smoking	0.6	0.9	2.3	-0.6	-0.2	-1.2	-1.0	-1.5
Depressed Affect (Nagel 2018)	0.5	1.0	3.0	-1.7	0.4	-1.4	0.1	-0.9
Ulcerative Colitis (UC)	0.5	0.9	2.1	0.7	-1.5	-1.2	-0.3	-1.1
LDL Cholesterol	0.5	0.7	1.4	1.2	0.4	1.1	-1.1	-0.5
Primary Biliary Cirrhosis	0.5	0.7	2.5	1.6	0.6	0.4	-0.8	-0.7
Schizophrenia (2014)	0.5	1.0	3.3	1.8	-0.8	1.1	-0.9	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.6	-0.3	-0.6	-2.1	0.8	-0.3
Chronotype (morning person)	0.5	1.1	2.6	1.6	1.2	1.2	-0.5	-0.7
Sensitivity / hurt feelings	0.5	0.9	3.2	0.2	0.6	-0.7	-1.2	-1.8
Medication: Metformin	0.5	0.6	3.0	-0.1	0.1	-1.7	0.0	-0.9
Diabetes (mother)	0.5	0.6	2.9	0.7	-1.7	-0.4	0.1	-0.5
Hand grip strength (right)	0.5	1.5	5.4	0.0	2.3	1.8	0.2	0.6
Fed-up feelings	0.5	1.0	2.9	-1.7	0.4	-1.1	-0.3	-1.2
Body mass index (BMI)	0.5	2.0	4.7	-2.2	0.1	0.3	-2.2	-1.6
Impedance of leg (left)	0.5	2.5	8.0	2.8	0.4	-0.1	2.4	0.9
Pain all over the body in last month	0.5	0.5	1.3	-1.1	0.7	0.6	-1.0	-0.3
Medication: Ramipril	0.5	0.6	3.2	0.4	0.4	0.1	-0.6	-1.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.8	-0.7	0.5	-1.5	2.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.9	-1.7	0.1	-0.5	0.3	-0.6
Pulse rate, automated reading	0.5	1.7	9.6	-3.1	0.3	0.5	0.2	0.5
Illnesses of siblings: Diabetes	0.5	0.7	1.7	1.3	-0.6	-1.1	0.4	-0.8
Smoking status: Previous	0.5	0.8	2.2	-1.5	1.4	0.7	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.3	0.8	1.8	-0.7	1.5	0.1
Osteoporosis (self-reported)	0.5	0.6	1.6	0.7	0.4	1.0	-0.4	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.7	0.4	-1.5	-1.9	0.3	-0.3
Number of self-reported non-cancer illnesses	0.5	0.8	2.2	1.5	1.4	0.5	-0.4	-0.6
Risk taking	0.5	0.7	2.1	1.0	-0.6	-0.5	-0.8	-1.5
Fractured/broken bones in last 5 years	0.5	0.7	1.9	-1.4	-0.3	-1.3	0.5	-0.3
Commuting to job workplace: Cycle	0.5	0.6	1.8	-0.7	1.0	1.3	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.3	-1.5	0.7	0.4	-0.3	-1.0
Schizophrenia (2018)	0.4	0.9	2.6	1.6	-1.1	0.6	-1.2	0.0
Triglycerides	0.4	0.6	2.5	1.6	0.8	0.4	-0.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	0.1	-0.6	0.1	-1.1	-0.9
Impedance of leg (right)	0.4	2.1	7.6	2.8	0.5	-0.4	2.1	0.7
Serious illness, injury or assault to yourself	0.4	0.5	2.3	1.5	-0.0	-0.1	-0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.2	-0.0	-1.5	-0.3	0.4	0.7
Number of incorrect matches in round	0.4	0.6	2.4	-0.0	-0.0	-0.2	-1.2	-1.6
Hearing difficulty/problems with background noise	0.4	0.6	1.5	-0.2	1.1	1.2	0.6	0.6
Forced vital capacity (FVC)	0.4	1.6	6.5	-0.7	0.3	-1.3	2.5	0.9
Mouth/teeth dental problems	0.4	0.6	1.1	0.2	-1.1	-0.9	-1.0	-0.9
Allergy	0.4	0.8	2.9	0.3	-0.2	-0.8	-1.1	-1.7
Medication: Simvastatin	0.4	0.6	1.9	0.3	-0.4	-1.2	-0.2	-1.4
Arm fat percentage (right)	0.4	1.5	3.4	-1.8	0.8	0.8	-1.8	-0.9
Hair/balding pattern: Pattern 3	0.4	0.5	2.6	0.4	0.5	0.2	1.6	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.7	-0.4	-1.1	0.6	1.3	1.2
Length of working week for main job	0.4	0.4	1.1	-1.1	-0.1	-0.1	-0.2	-1.1
Tense / ‘highly strung’	0.4	0.6	2.3	0.3	1.5	-0.2	-0.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.0	-1.4	1.1	-0.4	0.1	0.6
Glaucoma (self-reported)	0.4	0.5	1.1	1.0	0.2	-0.6	1.0	0.8
Birth weight	0.4	0.9	2.1	-1.1	-0.6	-0.0	1.4	1.5
Worry too long after embarrassment	0.4	0.7	1.6	1.3	1.2	0.3	0.9	0.7
Medication: Seretide 50 evohaler	0.4	0.4	2.0	-0.2	-0.6	-0.3	-1.4	-0.3
Mean time to correctly identify matches	0.4	0.8	2.7	-1.0	-0.8	-1.6	-0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	0.7	-0.6	-1.2	-0.2	-0.9
Had major operations	0.4	0.4	1.2	0.8	0.2	0.8	-0.3	-1.1
Arm fat percentage (left)	0.4	1.7	5.0	-2.2	0.6	0.6	-1.8	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	1.3	0.3	0.9	0.2	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	0.4	-0.3	-0.7	-0.5	-1.3
Medication for cholesterol	0.4	0.5	1.7	-0.9	-0.0	0.8	0.4	1.3
Medication: Gliclazide	0.4	0.4	1.8	-0.2	-0.6	-1.3	0.5	0.3
Average weekly champagne plus white wine intake	0.4	0.5	1.5	1.2	-0.2	0.7	0.8	0.7
Miserableness	0.4	0.7	1.9	-1.0	0.7	-0.9	1.4	0.3
High cholesterol (Self-reported)	0.4	0.8	1.5	1.1	1.2	1.2	-0.1	-0.6
Pain experienced in last month	0.4	0.7	2.0	-0.1	-1.4	-0.7	-1.2	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.6	-0.4	1.2	1.3	0.4	0.3
Bipolar Disorder or Schizophrenia	0.3	0.6	2.9	1.7	-0.7	0.2	-0.6	0.1
Worry (Nagel 2018)	0.3	0.7	1.7	1.2	1.3	-0.6	0.3	-0.8
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.1	-0.4	0.1	0.8	1.0
HbA1C	0.3	0.3	0.9	0.2	-0.9	-0.6	0.4	-0.5
Lupus	0.3	0.4	1.6	0.0	0.7	1.3	-0.4	0.4
Systolic Blood Pressure	0.3	1.3	5.6	2.4	0.1	1.3	-0.3	-0.1
Smoking Status	0.3	0.8	1.8	-0.5	-1.1	-1.4	-0.9	-0.8
Lung FEV1/FVC ratio	0.3	1.4	5.4	1.1	2.3	-0.4	1.1	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.7	0.2	-1.0	-0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.1	1.1	0.5	0.4	0.9
Medication for hormone replacement therapy	0.3	0.3	0.9	0.2	-0.2	0.1	-0.8	-1.0
Vitamin and mineral supplements	0.3	0.4	1.7	-0.3	-0.8	-1.3	-0.3	0.1
Supplements: Glucosamine	0.3	0.3	1.0	-0.0	-1.0	0.4	-0.5	-0.8
Sitting height	0.3	2.0	8.6	0.5	2.9	0.6	1.4	1.0
Past tobacco smoking	0.3	0.6	2.5	1.6	-0.9	0.0	0.6	0.1
Prospective memory result	0.3	0.4	1.4	-0.0	-0.3	-0.4	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.4	-0.5	0.5	-1.5	1.6	-0.3
Arm fat mass (right)	0.3	1.1	3.0	-1.7	1.2	0.5	-1.1	-0.8
Headache pain in last month	0.3	0.5	2.2	1.5	0.6	0.1	0.1	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.8	-0.3	-0.6	0.4	1.1
Forced vital capacity (FVC), Best measure	0.3	1.2	3.8	-1.0	0.2	-1.4	1.9	0.4
Eye problems/disorders: None of the above	0.3	0.4	0.7	0.7	-0.8	-0.6	0.2	0.8
Overall health rating	0.3	0.6	2.6	-0.4	1.6	-0.6	0.6	0.1
Supplements: Vitamin C	0.3	0.4	1.1	1.0	0.2	1.0	-0.3	0.3
Qualifications: nursing, teaching	0.3	0.5	1.0	-0.7	-0.2	0.6	1.0	1.0
Commuting to job workplace: Walk	0.3	0.3	0.6	0.7	-0.8	-0.7	0.2	-0.3
Eye problems/disorders: Cataract	0.3	0.3	1.0	-0.4	-0.0	1.0	-0.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.7	0.9	0.2	0.7	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.8	0.7	0.4	-0.2	-0.7
Mineral and other dietary supplements	0.3	0.3	1.9	-0.2	-0.3	-1.4	-0.1	0.1
Medication: Aspirin	0.3	0.3	1.6	-0.2	0.0	-0.7	1.3	0.0
Arm fat mass (left)	0.3	1.2	4.0	-2.0	1.1	0.3	-1.1	-0.7
Ever taken oral contraceptive pill	0.3	0.4	1.1	-1.0	-0.6	-0.8	0.4	-0.1
Financial situation satisfaction	0.3	0.4	1.3	-1.2	0.5	-0.4	0.8	-0.0
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	1.0	0.5	-0.8	0.5	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.2	0.2	1.2	0.6	0.5
Diastolic blood pressure, automated reading	0.3	0.8	2.2	0.0	0.5	1.2	-1.5	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.4	-0.8	-0.2	-0.3	1.5	1.5
Impedance of whole body	0.3	1.3	3.5	1.7	1.1	-0.3	1.9	0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.5	-0.2	0.9	-1.2	0.3	-0.4
Ovarian Cancer	0.2	0.2	0.5	-0.7	0.5	0.4	0.1	0.7
Prostate Cancer	0.2	0.3	0.7	0.6	0.2	-0.8	-0.7	-0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.2	0.5	0.5	-0.8	-0.1
Blood Platelet Count	0.2	2.1	8.9	-1.0	1.6	3.0	0.1	0.0
Blood Red Count	0.2	1.8	4.2	2.0	0.2	0.2	-1.7	-1.9
Blood White Count	0.2	1.3	4.2	1.8	-0.1	-0.1	-0.3	-2.0
Waist Hip Ratio (WHR)	0.2	1.0	2.1	1.4	1.2	0.0	1.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.7	-0.7	-0.5	-0.4	-0.3
Systolic blood pressure, automated reading	0.2	0.5	2.0	1.4	-0.3	0.8	-0.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.9	0.0	0.6	-0.0	-0.1
Angina	0.2	0.3	0.9	-0.1	-0.5	-1.0	-0.4	-0.7
Leg fat-free mass (left)	0.2	1.2	3.8	-1.9	1.7	-0.4	-0.6	-0.4
Trunk fat percentage	0.2	1.0	2.3	-1.3	1.5	0.5	-1.0	-1.0
Townsend deprivation index at recruitment	0.2	0.3	1.0	-0.8	1.0	0.2	-0.3	-0.4
Average weekly fortified wine intake	0.2	0.2	0.7	-0.1	0.0	-0.8	0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	-1.2	-0.7	-0.8	-0.4	-0.6
High blood pressure	0.2	0.6	2.0	0.9	0.2	-0.1	-1.0	-1.4
Leg predicted mass (left)	0.2	1.2	3.5	-1.9	1.6	-0.5	-0.7	-0.5
Trunk fat mass	0.2	1.0	3.2	-1.1	1.8	0.5	-0.9	-0.9
Waist circumference	0.2	0.6	1.9	-0.7	1.4	-0.1	-0.4	-0.9
Illnesses of siblings	0.2	0.3	1.3	-0.3	0.4	1.1	-0.2	0.6
Neuroticism score	0.2	0.4	1.3	0.4	1.1	-0.6	0.2	-0.7
Weight	0.2	0.9	3.6	-1.0	1.9	0.2	-0.6	-0.6
Impedance of arm (right)	0.2	0.8	2.4	0.6	1.5	0.6	1.1	0.9
Hip circumference	0.2	0.9	2.6	-1.6	1.2	-0.2	-0.8	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.1	-0.1	0.2	1.0	-0.3	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	-0.6	0.5	0.1	-0.8	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	0.4	0.3	0.5	1.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	1.0	0.5	-0.1	0.4	-0.2
Depression (self-reported)	0.2	0.3	0.7	0.3	0.2	0.9	0.2	-0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	1.2	0.8	0.2	-0.5	-0.9
Blood clot in the leg (DVT)	0.2	0.3	1.0	-0.0	1.0	1.0	0.0	0.0
Medication: Amlodipine	0.2	0.3	1.1	0.2	-1.0	-0.7	-0.2	0.1
Body fat percentage	0.2	0.9	1.8	-1.0	1.3	0.6	-1.2	-1.0
Leg fat percentage (right)	0.2	0.8	2.6	-0.6	0.4	0.3	-1.6	-1.3
Number of children fathered	0.2	0.2	1.1	0.4	0.5	-0.1	1.0	-0.2
Neck or shoulder pain in last month	0.2	0.3	1.2	-0.0	1.1	0.7	0.3	0.4
Whole body fat mass	0.2	1.0	2.8	-1.3	1.7	0.4	-1.0	-0.8
Leg fat mass (right)	0.2	0.8	1.7	-1.0	1.3	0.4	-1.2	-0.8
Alcohol intake frequency.	0.2	0.5	1.1	-0.6	1.0	-0.6	-0.6	-1.0
Suffer from ‘nerves’	0.2	0.3	0.9	-0.5	0.3	-0.7	1.0	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.7	-0.2	-0.5	0.8	-0.0
Medication: Aspirin	0.2	0.3	0.9	0.1	-0.5	-0.9	0.7	-0.3
Leg fat-free mass (right)	0.2	1.1	3.6	-1.9	1.6	-0.1	-0.5	-0.2
Ever had bowel cancer screening	0.2	0.3	0.7	0.5	-0.9	-0.1	0.7	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	0.9	0.0	-0.7	-0.4	0.4
Leg predicted mass (right)	0.2	1.1	3.6	-1.9	1.6	-0.1	-0.5	-0.2
Guilty feelings	0.2	0.3	0.6	0.4	0.8	0.7	-0.7	0.3
Wears glasses or contact lenses	0.2	0.2	0.5	-0.5	0.4	0.6	0.5	0.7
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.7	0.5	0.5	-0.7	-0.4
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.4	0.8	0.4	-0.8	-0.4
Medication: Lisinopril	0.2	0.2	0.5	0.0	0.4	-0.7	0.6	0.6
Medication: Atorvastatin	0.2	0.3	1.0	0.2	0.7	-0.0	-0.2	-1.0
Illnesses of father: High blood pressure	0.2	0.3	1.0	0.7	0.1	0.2	-0.3	-1.0
Leg fat percentage (left)	0.2	0.7	2.0	-0.4	0.6	0.6	-1.4	-1.2
Age started oral contraceptive pill	0.2	0.3	1.2	1.1	0.5	0.4	0.0	-0.1
Heart disease (siblings)	0.2	0.2	0.5	0.1	-0.7	-0.5	0.6	-0.3
Leg fat mass (left)	0.2	0.7	1.7	-1.1	1.3	0.5	-0.9	-0.7
Bipolar Disorder (2018)	0.1	0.2	0.5	0.7	0.2	-0.3	0.5	0.1
Crohns Disease (2017)	0.1	0.3	0.6	-0.7	0.5	0.3	0.6	0.8
Irritable Bowel Disease (IBD)	0.1	0.1	0.4	-0.1	-0.7	-0.5	0.3	-0.2
Fasting Glucose	0.1	0.1	0.4	0.0	0.1	-0.1	-0.3	-0.6
Ulcerative Colitis	0.1	0.1	0.3	0.5	-0.4	-0.1	0.2	-0.3
Heel T-Score	0.1	1.0	4.8	-2.2	-0.9	-0.3	-0.5	-0.0
Cardiovascular Disease	0.1	0.5	1.4	-0.3	0.7	0.9	-0.4	-1.2
Respiratory disease	0.1	0.3	1.1	-0.6	0.1	0.1	-1.0	-0.4
Neuroticism	0.1	0.2	0.6	-0.3	0.8	-0.6	0.3	-0.1
Tanning	0.1	1.8	4.5	1.3	1.4	2.1	-1.4	-0.7
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.3	0.5	0.3	-0.0	0.4
Diabetes (father)	0.1	0.1	0.3	-0.4	-0.0	0.6	-0.3	0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.7	-0.3	-0.0	0.8	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.7	0.4	0.3	0.8	0.3	0.1
Asthma	0.1	0.3	1.0	0.1	0.5	-0.0	0.5	1.0
Medication: Cholesterol lowering	0.1	0.2	0.4	0.6	0.7	0.7	-0.1	-0.0
Impedance of arm (left)	0.1	0.7	1.8	0.2	1.3	0.1	1.3	0.8
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.0	-0.4	-0.2	-0.4	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.4	0.6	-1.0	0.1	-0.5
Loud music exposure frequency	0.1	0.1	0.6	-0.1	-0.4	-0.4	-0.1	-0.8
Medication: Paracetamol	0.1	0.2	0.8	-0.7	-0.3	-0.9	0.0	0.1
Arm fat-free mass (right)	0.1	0.4	1.3	-0.5	1.1	-0.8	0.1	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.1	-0.5	0.7	-0.4	0.6
Angina (self-reported)	0.1	0.2	0.4	-0.3	-0.3	-0.6	-0.4	-0.6
Arm predicted mass (right)	0.1	0.4	1.6	-0.6	1.3	-0.7	0.2	-0.2
Knee pain experienced in last month	0.1	0.2	1.0	0.1	-0.4	0.1	1.0	-0.2
Hypertension (Self-reported)	0.1	0.4	1.6	0.5	0.3	0.0	-0.6	-1.3
Whole body fat-free mass	0.1	0.5	1.9	-1.0	1.4	-0.4	-0.1	-0.0
Asthma (self-reported)	0.1	0.3	1.0	-0.1	0.5	-0.2	0.7	1.0
Whole body water mass	0.1	0.5	1.8	-0.8	1.3	-0.4	-0.1	-0.0
Medication: Blood pressure	0.1	0.2	0.6	0.4	0.5	-0.2	0.8	0.2
Medication: Paracetamol	0.1	0.2	1.1	-0.2	0.3	-1.0	0.2	-0.2
Alcohol drinker status: Never	0.1	0.2	0.4	0.6	0.3	-0.2	-0.1	-0.7
Basal metabolic rate	0.1	0.6	2.6	-1.0	1.6	-0.3	-0.1	-0.1
Arm fat-free mass (left)	0.1	0.5	2.3	0.1	1.5	-0.7	0.3	-0.3
Supplements: Calcium	0.1	0.1	0.2	0.4	-0.4	0.1	0.1	-0.3
Arm predicted mass (left)	0.1	0.5	1.8	-0.2	1.4	-0.9	0.1	-0.4
Blood Eosinophil Count	0.0	0.2	0.5	-0.0	0.5	-0.5	0.7	0.3
Hair Pigment	0.0	0.5	1.8	0.2	-0.5	-0.8	1.4	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.5	0.4	0.4	-0.1	-0.1
Trunk fat-free mass	0.0	0.3	1.2	-0.2	1.1	-0.5	0.1	0.1
Trunk predicted mass	0.0	0.2	0.9	-0.2	0.9	-0.6	0.1	0.1
High blood pressure (siblings)	0.0	0.1	0.2	0.1	-0.2	-0.4	0.2	-0.2

Hub : Genes

ZNF518B

Models

Trait associations