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chr2:26,592,429-28,607,344

Best TWAS P=3.76e-24 · Best GWAS P=3.56e-24 conditioned to 0.0684

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	9.9	-10.1	3.8e-24	-0.95	0.00	0.92	TRUE
35	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	-5.8	8.6	7.5e-18	0.88	0.03	0.97	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	-5.8	-8.4	5.9e-17	-0.69	0.48	0.52	FALSE
37	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	-5.1	-7.9	2.1e-15	-0.71	0.61	0.39	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	-5.1	-7.9	2.7e-15	-0.67	0.86	0.14	FALSE
21	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	-5.4	7.5	8.6e-14	0.81	0.06	0.89	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	-6.0	-7.4	1.7e-13	-0.55	0.02	0.33	FALSE
34	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	-5.4	7.3	2.5e-13	0.82	0.02	0.97	FALSE
31	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	-5.3	7.3	3.0e-13	0.79	0.06	0.69	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	-5.3	-7.3	3.4e-13	-0.78	0.36	0.64	FALSE
20	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	-5.4	6.8	1.0e-11	0.74	0.91	0.09	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	-5.4	6.6	3.1e-11	0.75	0.62	0.38	FALSE
40	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	-4.7	6.5	1.0e-10	0.74	0.11	0.38	FALSE
32	GTEx	Pituitary	AC074117.10	0.23	0.23	lasso	8	0.29	5.6e-08	-5.6	6.2	4.5e-10	0.69	0.57	0.28	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	KRTCAP3	0.06	0.05	blup	279	0.05	3.1e-07	-5.3	-6.2	5.9e-10	-0.61	1.00	0.00	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	-5.7	6.1	8.3e-10	0.66	0.52	0.16	FALSE
11	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	-5.3	6.1	1.4e-09	0.70	0.27	0.17	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	-5.7	-6.0	1.5e-09	-0.66	0.43	0.50	FALSE
33	GTEx	Skin Sun Exposed Lower leg	SLC4A1AP	0.04	0.01	lasso	3	0.02	1.7e-02	-5.7	-6.0	2.0e-09	-0.61	0.21	0.12	FALSE
41	GTEx	Whole Blood	KRTCAP3	0.12	0.05	enet	10	0.05	9.9e-06	-5.3	-6.0	2.0e-09	-0.66	0.96	0.02	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	-5.6	6.0	2.2e-09	0.68	0.03	0.51	FALSE
42	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	-5.3	-5.8	5.0e-09	-0.55	0.96	0.03	FALSE
16	GTEx	Cells Transformed fibroblasts	IFT172	0.04	0.04	lasso	2	0.02	8.1e-03	-5.8	-5.8	5.4e-09	-0.64	0.16	0.41	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	-4.7	5.8	5.8e-09	0.65	0.67	0.09	FALSE
15	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	-5.7	5.8	7.1e-09	0.63	0.97	0.02	FALSE
27	GTEx	Muscle Skeletal	KRTCAP3	0.08	0.06	lasso	4	0.04	3.1e-05	-5.8	-5.8	7.9e-09	-0.61	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	-5.4	5.8	8.0e-09	0.66	0.56	0.10	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	6.2	5.8	8.0e-09	0.57	0.00	0.98	FALSE
23	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	-5.4	5.8	8.1e-09	0.66	0.91	0.08	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	-5.7	5.7	9.4e-09	0.64	0.57	0.09	FALSE
29	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	-5.4	5.7	9.5e-09	0.63	0.54	0.25	FALSE
39	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	-5.7	5.7	1.0e-08	0.63	1.00	0.00	FALSE
43	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	-5.4	5.7	1.0e-08	0.68	0.99	0.01	FALSE
9	GTEx	Adrenal Gland	KRTCAP3	0.11	0.16	lasso	4	0.15	4.9e-06	-5.7	-5.7	1.1e-08	-0.63	0.40	0.54	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBP1	0.03	0.04	lasso	1	0.03	5.2e-03	-5.7	5.7	1.1e-08	0.61	0.04	0.11	FALSE
12	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	-5.7	5.7	1.2e-08	0.64	1.00	0.00	FALSE
13	GTEx	Brain Cerebellum	AC074117.10	0.13	0.08	enet	6	0.07	4.4e-03	-5.6	-5.7	1.3e-08	-0.63	0.13	0.24	FALSE
49	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	-5.8	5.7	1.3e-08	0.62	0.99	0.01	FALSE
10	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	-5.7	5.7	1.5e-08	0.60	0.27	0.05	FALSE
18	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	-5.7	5.7	1.5e-08	0.62	0.91	0.02	FALSE
17	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	-5.4	5.7	1.6e-08	0.65	0.99	0.01	FALSE
8	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	-5.7	5.6	1.8e-08	0.62	0.89	0.03	FALSE
48	YFS	Blood	KRTCAP3	0.12	0.18	bslmm	286	0.18	1.0e-55	-5.3	-5.6	1.8e-08	-0.61	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	-5.3	5.6	1.9e-08	0.66	0.11	0.28	FALSE
22	GTEx	Esophagus Muscularis	PPM1G	0.06	0.10	lasso	2	0.07	3.7e-05	-5.8	5.6	2.3e-08	0.59	0.40	0.48	FALSE
25	GTEx	Lung	AC074117.10	0.07	0.06	lasso	6	0.05	6.6e-05	-5.3	5.6	2.7e-08	0.66	0.84	0.16	FALSE
26	GTEx	Muscle Skeletal	SNX17	0.18	0.24	lasso	6	0.26	6.2e-26	-5.4	5.5	2.8e-08	0.64	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	NRBP1	0.05	0.05	lasso	4	0.04	2.5e-03	-5.3	5.5	3.3e-08	0.63	0.34	0.06	FALSE
54	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	-5.4	5.5	4.0e-08	0.67	0.02	0.09	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	-5.4	5.5	4.0e-08	0.64	0.32	0.05	FALSE
38	GTEx	Thyroid	PPM1G	0.06	0.06	lasso	3	0.06	2.2e-05	-5.3	5.5	4.2e-08	0.62	0.92	0.01	FALSE
24	GTEx	Lung	NRBP1	0.05	0.05	enet	9	0.05	1.7e-04	-5.3	5.5	4.5e-08	0.64	0.77	0.13	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1G	0.03	0.02	blup	32	0.02	2.4e-03	-5.5	5.5	4.7e-08	0.63	0.16	0.05	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX17	0.02	0.01	blup	26	0.01	2.1e-02	-5.2	-5.4	5.5e-08	-0.64	0.13	0.18	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	43	0.02	2.7e-03	-5.2	5.4	5.8e-08	0.62	0.09	0.16	FALSE
28	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	2.7	5.4	6.8e-08	0.46	0.26	0.14	FALSE
7	GTEx	Adipose Visceral Omentum	KRTCAP3	0.10	0.07	lasso	4	0.06	5.2e-04	-5.4	-5.4	7.0e-08	-0.64	0.69	0.10	FALSE
30	GTEx	Nerve Tibial	PPM1G	0.09	0.06	lasso	4	0.05	1.2e-04	-5.6	5.4	8.5e-08	0.59	0.56	0.19	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	SNX17	0.27	0.35	lasso	10	0.34	7.9e-46	-5.3	-5.3	9.8e-08	-0.63	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBP1	0.03	0.05	blup	30	0.05	3.7e-06	-5.3	5.3	1.1e-07	0.61	0.96	0.02	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBP1	0.06	0.07	lasso	2	0.07	1.1e-08	-5.3	5.3	1.5e-07	0.62	0.99	0.01	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPM1G	0.03	0.03	blup	32	0.02	9.3e-04	-5.2	5.2	1.6e-07	0.59	0.36	0.05	FALSE
36	GTEx	Testis	RP11-195B17.1	0.13	0.00	lasso	4	0.02	4.5e-02	-5.3	5.2	1.7e-07	0.60	0.04	0.14	FALSE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBP1	0.05	0.06	lasso	2	0.05	6.0e-05	-5.2	5.2	1.8e-07	0.62	0.81	0.02	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KRTCAP3	0.02	0.01	blup	28	0.01	2.9e-02	-5.3	-5.2	2.1e-07	-0.59	0.08	0.05	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	-5.4	5.2	2.3e-07	0.67	0.04	0.73	FALSE
3	GTEx	Adipose Subcutaneous	PPM1G	0.04	0.05	lasso	2	0.04	4.9e-04	-5.3	5.1	2.7e-07	0.61	0.60	0.03	FALSE