[Hub]/) : Traits : Medication: Allopurinol :

chr2:26,592,429-28,607,344

Best TWAS P=3.76e-24 · Best GWAS P=3.56e-24 conditioned to 0.0684

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GTF3C2 0.06 0.09 lasso 8 0.08 7.2e-10 -5.4 6.6 3.1e-11 0.75 0.62 0.38 FALSE
2 CommonMind Brain Pre-frontal Cortex IFT172 0.06 0.09 enet 16 0.09 3.9e-11 -5.3 -7.3 3.4e-13 -0.78 0.36 0.64 FALSE
3 GTEx Adipose Subcutaneous PPM1G 0.04 0.05 lasso 2 0.04 4.9e-04 -5.3 5.1 2.7e-07 0.61 0.60 0.03 FALSE
4 GTEx Adipose Subcutaneous AC074117.10 0.06 0.04 lasso 5 0.02 4.8e-03 -5.4 5.8 8.0e-09 0.66 0.56 0.10 FALSE
5 GTEx Adipose Visceral Omentum NRBP1 0.05 0.05 lasso 4 0.04 2.5e-03 -5.3 5.5 3.3e-08 0.63 0.34 0.06 FALSE
6 GTEx Adipose Visceral Omentum PPM1G 0.06 0.01 lasso 5 0.01 1.1e-01 -5.3 5.6 1.9e-08 0.66 0.11 0.28 FALSE
7 GTEx Adipose Visceral Omentum KRTCAP3 0.10 0.07 lasso 4 0.06 5.2e-04 -5.4 -5.4 7.0e-08 -0.64 0.69 0.10 FALSE
8 GTEx Adipose Visceral Omentum AC074117.10 0.14 0.09 lasso 3 0.08 5.0e-05 -5.7 5.6 1.8e-08 0.62 0.89 0.03 FALSE
9 GTEx Adrenal Gland KRTCAP3 0.11 0.16 lasso 4 0.15 4.9e-06 -5.7 -5.7 1.1e-08 -0.63 0.40 0.54 FALSE
10 GTEx Artery Aorta AC074117.10 0.06 0.04 lasso 3 0.03 6.8e-03 -5.7 5.7 1.5e-08 0.60 0.27 0.05 FALSE
11 GTEx Artery Tibial PPM1G 0.06 0.02 lasso 4 0.03 2.3e-03 -5.3 6.1 1.4e-09 0.70 0.27 0.17 FALSE
12 GTEx Artery Tibial AC074117.10 0.13 0.14 lasso 5 0.13 1.1e-10 -5.7 5.7 1.2e-08 0.64 1.00 0.00 FALSE
13 GTEx Brain Cerebellum AC074117.10 0.13 0.08 enet 6 0.07 4.4e-03 -5.6 -5.7 1.3e-08 -0.63 0.13 0.24 FALSE
14 GTEx Cells EBV-transformed lymphocytes NRBP1 0.11 0.13 enet 13 0.15 1.2e-05 -5.7 5.7 9.4e-09 0.64 0.57 0.09 FALSE
15 GTEx Cells Transformed fibroblasts NRBP1 0.09 0.08 lasso 3 0.08 7.8e-07 -5.7 5.8 7.1e-09 0.63 0.97 0.02 FALSE
16 GTEx Cells Transformed fibroblasts IFT172 0.04 0.04 lasso 2 0.02 8.1e-03 -5.8 -5.8 5.4e-09 -0.64 0.16 0.41 FALSE
17 GTEx Cells Transformed fibroblasts AC074117.10 0.21 0.19 enet 23 0.18 1.6e-13 -5.4 5.7 1.6e-08 0.65 0.99 0.01 FALSE
18 GTEx Colon Sigmoid AC074117.10 0.13 0.18 lasso 3 0.14 1.1e-05 -5.7 5.7 1.5e-08 0.62 0.91 0.02 FALSE
19 GTEx Esophagus Gastroesophageal Junction AC074117.10 0.12 0.13 enet 9 0.09 4.9e-04 -5.7 6.1 8.3e-10 0.66 0.52 0.16 FALSE
20 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 -5.4 6.8 1.0e-11 0.74 0.91 0.09 FALSE
21 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 -5.4 7.5 8.6e-14 0.81 0.06 0.89 FALSE
22 GTEx Esophagus Muscularis PPM1G 0.06 0.10 lasso 2 0.07 3.7e-05 -5.8 5.6 2.3e-08 0.59 0.40 0.48 FALSE
23 GTEx Esophagus Muscularis AC074117.10 0.17 0.14 enet 5 0.09 6.6e-06 -5.4 5.8 8.1e-09 0.66 0.91 0.08 FALSE
24 GTEx Lung NRBP1 0.05 0.05 enet 9 0.05 1.7e-04 -5.3 5.5 4.5e-08 0.64 0.77 0.13 FALSE
25 GTEx Lung AC074117.10 0.07 0.06 lasso 6 0.05 6.6e-05 -5.3 5.6 2.7e-08 0.66 0.84 0.16 FALSE
26 GTEx Muscle Skeletal SNX17 0.18 0.24 lasso 6 0.26 6.2e-26 -5.4 5.5 2.8e-08 0.64 1.00 0.00 FALSE
27 GTEx Muscle Skeletal KRTCAP3 0.08 0.06 lasso 4 0.04 3.1e-05 -5.8 -5.8 7.9e-09 -0.61 1.00 0.00 FALSE
28 GTEx Muscle Skeletal GPN1 0.06 0.02 enet 9 0.02 2.9e-03 2.7 5.4 6.8e-08 0.46 0.26 0.14 FALSE
29 GTEx Nerve Tibial NRBP1 0.06 0.00 enet 9 0.02 2.0e-02 -5.4 5.7 9.5e-09 0.63 0.54 0.25 FALSE
30 GTEx Nerve Tibial PPM1G 0.09 0.06 lasso 4 0.05 1.2e-04 -5.6 5.4 8.5e-08 0.59 0.56 0.19 FALSE
31 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 -5.3 7.3 3.0e-13 0.79 0.06 0.69 FALSE
32 GTEx Pituitary AC074117.10 0.23 0.23 lasso 8 0.29 5.6e-08 -5.6 6.2 4.5e-10 0.69 0.57 0.28 FALSE
33 GTEx Skin Sun Exposed Lower leg SLC4A1AP 0.04 0.01 lasso 3 0.02 1.7e-02 -5.7 -6.0 2.0e-09 -0.61 0.21 0.12 FALSE
34 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 -5.4 7.3 2.5e-13 0.82 0.02 0.97 FALSE
35 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 -5.8 8.6 7.5e-18 0.88 0.03 0.97 FALSE
36 GTEx Testis RP11-195B17.1 0.13 0.00 lasso 4 0.02 4.5e-02 -5.3 5.2 1.7e-07 0.60 0.04 0.14 FALSE
37 GTEx Thyroid FNDC4 0.24 0.10 enet 23 0.16 2.2e-12 -5.1 -7.9 2.1e-15 -0.71 0.61 0.39 FALSE
38 GTEx Thyroid PPM1G 0.06 0.06 lasso 3 0.06 2.2e-05 -5.3 5.5 4.2e-08 0.62 0.92 0.01 FALSE
39 GTEx Thyroid AC074117.10 0.17 0.14 lasso 4 0.15 2.7e-11 -5.7 5.7 1.0e-08 0.63 1.00 0.00 FALSE
40 GTEx Vagina AC074117.10 0.14 0.04 enet 13 0.06 1.4e-02 -4.7 6.5 1.0e-10 0.74 0.11 0.38 FALSE
41 GTEx Whole Blood KRTCAP3 0.12 0.05 enet 10 0.05 9.9e-06 -5.3 -6.0 2.0e-09 -0.66 0.96 0.02 FALSE
42 METSIM Adipose KRTCAP3 0.05 0.01 blup 288 0.03 1.6e-05 -5.3 -5.8 5.0e-09 -0.55 0.96 0.03 FALSE
43 METSIM Adipose NRBP1 0.06 0.09 lasso 3 0.08 1.6e-12 -5.4 5.7 1.0e-08 0.68 0.99 0.01 FALSE
44 ROSMAP Brain Pre-frontal Cortex SNX17 0.27 0.35 lasso 10 0.34 7.9e-46 -5.3 -5.3 9.8e-08 -0.63 1.00 0.00 FALSE
45 ROSMAP Brain Pre-frontal Cortex IFT172 0.07 0.02 blup 287 0.03 5.8e-05 -5.7 -6.0 1.5e-09 -0.66 0.43 0.50 FALSE
46 ROSMAP Brain Pre-frontal Cortex KRTCAP3 0.06 0.05 blup 279 0.05 3.1e-07 -5.3 -6.2 5.9e-10 -0.61 1.00 0.00 FALSE
47 ROSMAP Brain Pre-frontal Cortex FTH1P3 0.04 0.01 bslmm 280 0.02 2.8e-03 -5.4 5.2 2.3e-07 0.67 0.04 0.73 FALSE
48 YFS Blood KRTCAP3 0.12 0.18 bslmm 286 0.18 1.0e-55 -5.3 -5.6 1.8e-08 -0.61 1.00 0.00 FALSE
49 YFS Blood NRBP1 0.01 0.01 lasso 6 0.01 9.1e-06 -5.8 5.7 1.3e-08 0.62 0.99 0.01 FALSE
50 The Cancer Genome Atlas Bladder Urothelial Carcinoma NRBP1 0.05 0.06 lasso 2 0.05 6.0e-05 -5.2 5.2 1.8e-07 0.62 0.81 0.02 FALSE
51 The Cancer Genome Atlas Bladder Urothelial Carcinoma PPM1G 0.03 0.02 blup 31 0.02 8.8e-03 -5.6 6.0 2.2e-09 0.68 0.03 0.51 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma GPN1 0.06 0.02 lasso 6 0.02 7.2e-05 6.2 5.8 8.0e-09 0.57 0.00 0.98 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma NRBP1 0.03 0.04 lasso 1 0.03 5.2e-03 -5.7 5.7 1.1e-08 0.61 0.04 0.11 FALSE
54 The Cancer Genome Atlas Glioblastoma Multiforme NRBP1 0.15 0.10 lasso 2 0.10 5.8e-04 -5.4 5.5 4.0e-08 0.67 0.02 0.09 FALSE
55 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IFT172 0.02 0.01 blup 43 0.02 2.7e-03 -5.2 5.4 5.8e-08 0.62 0.09 0.16 FALSE
56 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KRTCAP3 0.02 0.01 blup 28 0.01 2.9e-02 -5.3 -5.2 2.1e-07 -0.59 0.08 0.05 FALSE
57 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NRBP1 0.06 0.07 lasso 2 0.07 1.1e-08 -5.3 5.3 1.5e-07 0.62 0.99 0.01 FALSE
58 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX17 0.02 0.01 blup 26 0.01 2.1e-02 -5.2 -5.4 5.5e-08 -0.64 0.13 0.18 FALSE
59 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FNDC4 0.13 0.06 lasso 2 0.05 1.1e-03 9.9 -10.1 3.8e-24 -0.95 0.00 0.92 TRUE
60 The Cancer Genome Atlas Brain Lower Grade Glioma PPM1G 0.03 0.03 blup 32 0.02 9.3e-04 -5.2 5.2 1.6e-07 0.59 0.36 0.05 FALSE
61 The Cancer Genome Atlas Lung Adenocarcinoma NRBP1 0.03 0.05 blup 30 0.05 3.7e-06 -5.3 5.3 1.1e-07 0.61 0.96 0.02 FALSE
62 The Cancer Genome Atlas Prostate Adenocarcinoma NRBP1 0.03 0.03 blup 30 0.03 2.2e-04 -4.7 5.8 5.8e-09 0.65 0.67 0.09 FALSE
63 The Cancer Genome Atlas Prostate Adenocarcinoma PPM1G 0.03 0.02 blup 32 0.02 2.4e-03 -5.5 5.5 4.7e-08 0.63 0.16 0.05 FALSE
64 The Cancer Genome Atlas Thyroid Carcinoma FNDC4 0.24 0.09 enet 9 0.17 1.9e-16 -5.8 -8.4 5.9e-17 -0.69 0.48 0.52 FALSE
65 The Cancer Genome Atlas Thyroid Carcinoma GCKR 0.18 0.08 enet 5 0.13 1.7e-12 -5.1 -7.9 2.7e-15 -0.67 0.86 0.14 FALSE
66 The Cancer Genome Atlas Thyroid Carcinoma IFT172 0.08 0.01 blup 43 0.02 6.1e-03 -6.0 -7.4 1.7e-13 -0.55 0.02 0.33 FALSE
67 The Cancer Genome Atlas Thyroid Carcinoma NRBP1 0.03 0.01 blup 30 0.02 5.3e-03 -5.4 5.5 4.0e-08 0.64 0.32 0.05 FALSE