Best TWAS P=7.1e-09 · Best GWAS P=2.94e-08 conditioned to 0.0286
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SEPT4 | 0.03 | 0.00 | bslmm | 333 | 0.01 | 4.0e-02 | 5.3 | -5.5 | 4.1e-08 | -0.79 | 0.03 | 0.76 | FALSE |
| 2 | GTEx | Adrenal Gland | TRIM37 | 0.10 | 0.02 | enet | 17 | 0.01 | 9.9e-02 | 5.3 | 5.3 | 1.3e-07 | 0.87 | 0.04 | 0.85 | FALSE |
| 3 | GTEx | Artery Tibial | SKA2 | 0.07 | 0.07 | lasso | 5 | 0.08 | 1.4e-06 | 5.2 | -5.2 | 1.9e-07 | -0.89 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Muscle Skeletal | SKA2 | 0.04 | 0.02 | enet | 12 | 0.04 | 1.0e-04 | 4.6 | -5.8 | 7.1e-09 | -0.68 | 0.06 | 0.86 | TRUE |
| 5 | GTEx | Nerve Tibial | SKA2 | 0.10 | 0.08 | lasso | 6 | 0.09 | 4.4e-07 | 5.3 | -5.6 | 1.8e-08 | -0.93 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Whole Blood | AC099850.1 | 0.04 | 0.04 | lasso | 3 | 0.05 | 3.2e-05 | -4.0 | 5.3 | 1.0e-07 | 0.84 | 0.06 | 0.92 | FALSE |
| 7 | METSIM | Adipose | TEX14 | 0.05 | 0.05 | lasso | 2 | 0.04 | 4.1e-07 | 5.3 | 5.3 | 1.3e-07 | 0.99 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SKA2 | 0.04 | 0.01 | blup | 42 | 0.02 | 1.7e-02 | 5.3 | -5.5 | 2.9e-08 | -0.84 | 0.00 | 0.87 | FALSE |
| 9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TRIM37 | 0.10 | 0.05 | blup | 62 | 0.07 | 2.7e-04 | 4.5 | 5.3 | 1.4e-07 | 0.88 | 0.02 | 0.88 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TEX14 | 0.04 | 0.02 | blup | 76 | 0.03 | 4.7e-04 | -4.5 | 5.5 | 3.0e-08 | 0.89 | 0.03 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TEX14 | 0.10 | 0.08 | enet | 8 | 0.10 | 2.1e-11 | 4.9 | 5.5 | 4.6e-08 | 0.90 | 0.02 | 0.97 | FALSE |