Best TWAS P=8.02e-11 · Best GWAS P=9.36e-10 conditioned to 4.59e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | WNT2B | 0.18 | 0.07 | lasso | 6 | 0.05 | 0.02330 | -5.2 | -5.4 | 6.2e-08 | -0.15 | 0.08 | 0.12 | FALSE |
| 2 | GTEx | Muscle Skeletal | WNT2B | 0.06 | 0.02 | lasso | 7 | 0.03 | 0.00094 | -5.2 | -5.7 | 1.6e-08 | -0.14 | 0.38 | 0.33 | FALSE |
| 3 | GTEx | Thyroid | CAPZA1 | 0.09 | 0.02 | enet | 22 | 0.03 | 0.00169 | -4.6 | -5.3 | 1.2e-07 | -0.22 | 0.35 | 0.20 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CTTNBP2NL | 0.04 | 0.00 | blup | 53 | 0.02 | 0.00211 | -4.6 | -5.4 | 8.6e-08 | -0.12 | 0.03 | 0.19 | TRUE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 0.00047 | -4.9 | -5.7 | 1.4e-08 | -0.32 | 0.04 | 0.40 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 0.00014 | -5.2 | -6.5 | 8.0e-11 | -0.39 | 0.16 | 0.36 | TRUE |