Hub : Traits :

Medication: Bendroflumethiazide

59 significantly associated models · 38 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 26428864 27820430 1 1 3.0e-07 1.4e-06 6.9e-03 69 PIGV
2 1 112312154 113907148 4 2 8.0e-11 9.4e-10 4.6e-05 56 CTTNBP2NL RHOC
3 3 26720690 28211713 1 1 1.7e-07 2.1e-08 4.1e-02 87 SLC4A7
4 5 130830617 132304222 2 1 3.1e-08 1.6e-07 1.0e+00 100 PDLIM4
5 7 26969253 27533292 2 1 1.2e-10 6.1e-14 1.1e-04 74 HOXA10
6 8 8092025 9669775 2 1 6.7e-09 1.2e-08 8.6e-03 79 ERI1
7 8 10056664 11891593 6 1 9.5e-09 1.6e-08 5.7e-04 63 NEIL2
8 11 1213806 2640824 3 3 3.5e-15 3.6e-16 5.7e-02 94 LSP1 TNNI2 TNNT3
9 11 46570859 47977454 2 1 6.1e-09 1.4e-06 5.6e-01 98 ACP2
10 11 99859184 101559718 2 1 1.6e-07 8.5e-08 1.0e+00 100 ARHGAP42
11 15 74042497 75930199 4 1 2.7e-08 7.7e-08 1.0e+00 100 ULK3
12 15 90730363 92135418 1 1 8.3e-08 1.8e-07 3.3e-01 96 FES
13 16 3969463 5433992 1 1 9.8e-08 1.6e-05 8.8e-02 84 MGRN1
14 16 29711343 31102321 5 2 1.0e-09 5.2e-07 4.5e-01 98 ALDOA ZNF48
15 20 7847156 9112333 1 1 2.2e-07 2.9e-10 3.2e-04 68 PLCB1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 1.54 2 0 0.0 0.00 1.0e+00 FES ULK3
Bipolar Disorder or Schizophrenia 3.05 3 2 4.4 0.00 1.0e+00 ALDOA ERI1 FES
Depressed Affect (Nagel 2018) 1.32 1 1 2.2 0.00 1.0e+00 ACP2
Neuroticism (Nagel 2018) 1.38 2 1 2.2 0.00 1.0e+00 ACP2 FES
Schizophrenia (2018) 3.09 3 1 2.2 0.00 1.0e+00 ALDOA ERI1 FES
Worry (Nagel 2018) 1.56 2 0 0.0 0.00 1.0e+00 ALDOA ZNF48
Alzheimer’s Disease (including proxy) 1.15 1 0 0.0 0.00 1.0e+00 ZNF48
Crohns Disease (2017) 2.72 1 1 2.2 0.00 1.0e+00 PDLIM4
Irritable Bowel Disease (IBD) 2.83 3 1 2.2 0.00 1.0e+00 LSP1 PDLIM4 TNNI2
Ulcerative Colitis (UC) 2.30 1 1 2.2 0.00 1.0e+00 TNNI2
Breast Cancer 8.44 6 3 6.7 0.62 1.9e-01 FES LSP1 PDLIM4 SLC4A7 TNNT3 ULK3
Prostate Cancer 1.67 1 0 0.0 0.00 1.0e+00 HOXA10
Crohns Disease (2012) 2.09 1 1 2.2 0.00 1.0e+00 PDLIM4
Mean Putamen Volume 1.61 1 0 0.0 0.00 1.0e+00 NEIL2
Fasting Glucose 3.12 1 1 2.2 0.00 1.0e+00 ACP2
HDL Cholesterol 2.63 2 1 2.2 0.00 1.0e+00 ACP2 PIGV
Lupus 2.29 1 0 0.0 0.00 1.0e+00 ERI1
Neuroticism (2016) 3.17 2 2 4.4 0.00 1.0e+00 ERI1 NEIL2
Schizophrenia (2014) 2.90 3 1 2.2 0.00 1.0e+00 ALDOA ERI1 FES
Triglycerides 2.93 3 0 0.0 0.00 1.0e+00 ERI1 NEIL2 PDLIM4
Ulcerative Colitis 3.31 1 0 0.0 0.00 1.0e+00 TNNI2
Blood Eosinophil Count 7.97 4 3 6.7 0.36 6.4e-01 ALDOA PDLIM4 PIGV ZNF48
Blood Platelet Count 2.44 11 5 11.1 0.09 8.0e-01 ALDOA ARHGAP42 CTTNBP2NL MGRN1 PDLIM4 PIGV RHOC SLC4A7 TNNI2 ULK3 ZNF48
Blood Red Count 2.24 9 2 4.4 -0.34 3.7e-01 ALDOA FES LSP1 MGRN1 PLCB1 RHOC TNNI2 ULK3 ZNF48
Blood White Count 3.56 8 3 6.7 0.27 5.2e-01 ALDOA ARHGAP42 FES MGRN1 PDLIM4 PLCB1 TNNI2 ZNF48
Heel T-Score 2.10 8 5 11.1 -0.55 1.5e-01 ACP2 ALDOA ARHGAP42 CTTNBP2NL HOXA10 RHOC SLC4A7 ZNF48
BMI 2.77 3 2 4.4 0.00 1.0e+00 ALDOA ULK3 ZNF48
Height 2.76 14 8 17.8 -0.44 1.2e-01 ACP2 ALDOA ARHGAP42 FES HOXA10 LSP1 MGRN1 PDLIM4 PIGV RHOC SLC4A7 TNNI2 TNNT3 ZNF48
Waist Hip Ratio (WHR) 0.90 2 0 0.0 0.00 1.0e+00 TNNT3 ULK3
Systolic Blood Pressure 21.72 14 14 31.1 0.95 2.3e-07 ACP2 ARHGAP42 CTTNBP2NL FES HOXA10 LSP1 MGRN1 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3
Smoking Status 0.97 1 0 0.0 0.00 1.0e+00 FES
Allergy or Eczema 2.21 3 1 2.2 0.00 1.0e+00 FES PDLIM4 ULK3
Cardiovascular Disease 17.22 17 14 31.1 0.95 8.5e-09 ACP2 ALDOA ARHGAP42 CTTNBP2NL FES HOXA10 LSP1 MGRN1 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Respiratory disease 3.06 2 1 2.2 0.00 1.0e+00 FES PDLIM4
Type 2 Diabetes (T2D) (2018) 1.27 1 0 0.0 0.00 1.0e+00 ALDOA
Lung FEV1/FVC ratio 1.54 5 3 6.7 -0.61 2.8e-01 ALDOA ARHGAP42 CTTNBP2NL PDLIM4 ZNF48
Lung FVC 1.62 4 2 4.4 0.59 4.1e-01 CTTNBP2NL HOXA10 PDLIM4 ZNF48
Neuroticism 1.20 1 0 0.0 0.00 1.0e+00 ACP2
Chronotype (morning person) 1.31 2 0 0.0 0.00 1.0e+00 ACP2 ALDOA
Hair Pigment 0.22 3 2 4.4 0.00 1.0e+00 ACP2 ARHGAP42 FES
Tanning 0.21 1 0 0.0 0.00 1.0e+00 ULK3
Hand grip strength (left) 3.44 6 2 4.4 -0.34 5.0e-01 ALDOA FES MGRN1 PDLIM4 RHOC ZNF48
Number of treatments/medications taken 4.72 7 0 0.0 0.98 5.3e-05 ARHGAP42 FES MGRN1 PDLIM4 RHOC SLC4A7 ZNF48
Sensitivity / hurt feelings 2.99 2 2 4.4 0.00 1.0e+00 ERI1 FES
Frequency of depressed mood in last 2 weeks 1.55 1 0 0.0 0.00 1.0e+00 NEIL2
Systolic blood pressure, automated reading 15.67 14 11 24.4 0.94 7.7e-07 ACP2 ARHGAP42 ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PIGV RHOC SLC4A7 TNNI2 TNNT3 ULK3
Angina 3.79 2 1 2.2 0.00 1.0e+00 ARHGAP42 FES
Diabetes (father) 1.77 1 0 0.0 0.00 1.0e+00 ALDOA
Diabetes (mother) 1.86 1 0 0.0 0.00 1.0e+00 ZNF48
Impedance of leg (right) 4.52 7 5 11.1 -0.76 4.8e-02 ALDOA ARHGAP42 ERI1 FES NEIL2 RHOC ZNF48
Leg fat-free mass (left) 4.34 7 3 6.7 0.31 5.0e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Trunk fat percentage 2.37 5 3 6.7 0.01 9.9e-01 ALDOA HOXA10 SLC4A7 TNNT3 ZNF48
Hand grip strength (right) 3.19 4 1 2.2 -0.22 7.8e-01 ALDOA PDLIM4 RHOC ZNF48
Current tobacco smoking 1.78 1 0 0.0 0.00 1.0e+00 ERI1
Fed-up feelings 2.21 3 0 0.0 0.00 1.0e+00 ACP2 ERI1 NEIL2
Age when periods started (menarche) 2.53 3 1 2.2 0.00 1.0e+00 ALDOA TNNI2 TNNT3
Heel bone mineral density (BMD) T-score, automated (left) 3.86 4 2 4.4 0.45 5.5e-01 ACP2 ARHGAP42 ERI1 NEIL2
High blood pressure 23.09 19 16 35.6 0.95 4.5e-10 ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Hayfever, allergic rhinitis or eczema 2.32 3 1 2.2 0.00 1.0e+00 FES PDLIM4 ULK3
Supplements: Glucosamine 1.70 1 0 0.0 0.00 1.0e+00 ULK3
Medication: Atenolol 8.15 5 1 2.2 0.97 6.7e-03 ARHGAP42 FES RHOC TNNT3 ULK3
Medication: Levothyroxine sodium 1.50 1 0 0.0 0.00 1.0e+00 ERI1
Sitting height 1.52 4 1 2.2 -0.98 2.4e-02 FES NEIL2 PDLIM4 SLC4A7
High blood pressure (mother) 10.64 8 1 2.2 0.91 1.4e-03 ACP2 ARHGAP42 FES HOXA10 LSP1 RHOC SLC4A7 TNNT3
Body mass index (BMI) 4.00 4 3 6.7 0.99 8.6e-03 ALDOA ERI1 NEIL2 ZNF48
Impedance of leg (left) 4.35 7 5 11.1 -0.75 5.4e-02 ALDOA ARHGAP42 ERI1 FES NEIL2 RHOC ZNF48
Leg predicted mass (left) 4.35 7 3 6.7 0.31 4.9e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Trunk fat mass 3.03 3 2 4.4 0.00 1.0e+00 ALDOA HOXA10 ZNF48
Waist circumference 4.18 3 2 4.4 0.00 1.0e+00 ALDOA ULK3 ZNF48
Number of incorrect matches in round 3.03 2 1 2.2 0.00 1.0e+00 ALDOA FES
Alcohol usually taken with meals 1.82 1 0 0.0 0.00 1.0e+00 FES
Nervous feelings 3.53 5 1 2.2 -0.68 2.1e-01 ACP2 ALDOA ERI1 NEIL2 ZNF48
Frequency of tenseness / restlessness in last 2 weeks 1.58 1 0 0.0 0.00 1.0e+00 ZNF48
Hearing difficulty/problems with background noise 1.96 1 0 0.0 0.00 1.0e+00 ULK3
Forced vital capacity (FVC) 1.66 3 1 2.2 0.00 1.0e+00 ACP2 ARHGAP42 RHOC
Heel bone mineral density (BMD) T-score, automated (right) 3.79 4 2 4.4 0.24 7.6e-01 ACP2 ARHGAP42 ERI1 NEIL2
Mouth/teeth dental problems 2.22 1 0 0.0 0.00 1.0e+00 ERI1
Heart attack 2.02 1 1 2.2 0.00 1.0e+00 FES
Allergy 2.55 2 1 2.2 0.00 1.0e+00 FES PDLIM4
Medication: Ramipril 8.51 7 1 2.2 0.97 2.8e-04 ACP2 ARHGAP42 FES HOXA10 LSP1 TNNT3 ULK3
Medication: Simvastatin 3.90 3 1 2.2 0.00 1.0e+00 ARHGAP42 FES PIGV
Illnesses of siblings 4.43 3 1 2.2 0.00 1.0e+00 ARHGAP42 FES RHOC
Neuroticism score 3.21 3 2 4.4 0.00 1.0e+00 ACP2 ERI1 NEIL2
Weight 4.36 5 2 4.4 0.61 2.8e-01 ALDOA ERI1 NEIL2 PDLIM4 ZNF48
Impedance of arm (right) 4.37 9 4 8.9 -0.92 4.5e-04 ALDOA ERI1 HOXA10 LSP1 NEIL2 SLC4A7 TNNI2 TNNT3 ZNF48
Arm fat percentage (right) 3.10 4 3 6.7 0.50 5.0e-01 ALDOA ERI1 HOXA10 ZNF48
Trunk fat-free mass 4.02 7 3 6.7 0.25 5.9e-01 ACP2 ALDOA ARHGAP42 NEIL2 PDLIM4 SLC4A7 ZNF48
Hip circumference 3.51 3 2 4.4 0.00 1.0e+00 ALDOA ERI1 ZNF48
Alcohol intake versus 10 years previously 1.26 1 0 0.0 0.00 1.0e+00 ALDOA
Father's age at death 3.75 4 1 2.2 -0.99 1.2e-02 ERI1 FES PDLIM4 ULK3
Worrier / anxious feelings 4.05 2 2 4.4 0.00 1.0e+00 ERI1 NEIL2
Forced expiratory volume in 1-second (FEV1) 1.87 4 0 0.0 -0.99 7.0e-03 ARHGAP42 ERI1 PDLIM4 RHOC
Qualifications: A levels/AS levels or equivalent 1.21 1 0 0.0 0.00 1.0e+00 ULK3
Mouth/teeth dental problems: Dentures 2.44 2 0 0.0 0.00 1.0e+00 ALDOA ERI1
Asthma 3.53 1 1 2.2 0.00 1.0e+00 PDLIM4
Medication: Ibuprofen (e.g. Nurofen) 1.33 1 0 0.0 0.00 1.0e+00 ULK3
Medication: Cholesterol lowering 4.08 3 1 2.2 0.00 1.0e+00 ARHGAP42 FES PIGV
Illnesses of mother 6.97 5 1 2.2 -0.91 3.1e-02 ARHGAP42 FES HOXA10 LSP1 SLC4A7
Forced expiratory volume in 1-second (FEV1), Best measure 1.88 6 0 0.0 -1.00 3.2e-05 ACP2 ARHGAP42 ERI1 PDLIM4 RHOC ZNF48
Pulse wave Arterial Stiffness index 1.89 1 0 0.0 0.00 1.0e+00 FES
Impedance of arm (left) 4.36 9 5 11.1 -0.91 5.9e-04 ALDOA ERI1 HOXA10 LSP1 NEIL2 SLC4A7 TNNI2 TNNT3 ZNF48
Arm fat mass (right) 3.98 5 2 4.4 0.59 2.9e-01 ALDOA ERI1 HOXA10 NEIL2 ZNF48
Trunk predicted mass 4.00 7 3 6.7 0.25 5.9e-01 ACP2 ALDOA ARHGAP42 NEIL2 PDLIM4 SLC4A7 ZNF48
Standing height 2.71 8 4 8.9 -0.51 1.9e-01 ACP2 ALDOA ERI1 LSP1 MGRN1 PDLIM4 RHOC SLC4A7
Breastfed as a baby 2.43 2 0 0.0 0.00 1.0e+00 FES PIGV
Tense / 'highly strung' 2.93 3 1 2.2 0.00 1.0e+00 ALDOA ERI1 NEIL2
Hair/balding pattern: Pattern 4 0.91 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 4.68 3 1 2.2 0.00 1.0e+00 FES NEIL2 PDLIM4
Peak expiratory flow (PEF) 1.77 3 0 0.0 0.00 1.0e+00 ERI1 PDLIM4 ULK3
Pulse wave reflection index 1.63 1 0 0.0 0.00 1.0e+00 NEIL2
Ever highly irritable/argumentative for 2 days 2.46 1 0 0.0 0.00 1.0e+00 LSP1
Qualifications: O levels/GCSEs or equivalent 1.98 1 0 0.0 0.00 1.0e+00 ULK3
Mouth/teeth dental problems: Bleeding gums 1.56 1 0 0.0 0.00 1.0e+00 ACP2
Headache pain in last month 1.61 2 0 0.0 0.00 1.0e+00 ERI1 FES
Medication for cholesterol, blood pressure or diabetes 11.04 11 3 6.7 -0.91 1.2e-04 ACP2 ARHGAP42 CTTNBP2NL FES LSP1 PIGV PLCB1 RHOC SLC4A7 TNNI2 ULK3
Hypothyroidism/myxoedema (self-reported) 2.00 2 1 2.2 0.00 1.0e+00 ERI1 NEIL2
Medication: Amlodipine 13.88 11 6 13.3 0.98 2.2e-07 ACP2 ARHGAP42 CTTNBP2NL FES HOXA10 LSP1 MGRN1 RHOC SLC4A7 TNNI2 TNNT3
Medication: Ventolin 100micrograms inhaler 2.18 1 0 0.0 0.00 1.0e+00 PDLIM4
Birth weight 2.58 3 1 2.2 0.00 1.0e+00 FES HOXA10 PDLIM4
High blood pressure (siblings) 7.72 7 1 2.2 0.95 8.7e-04 ACP2 ARHGAP42 FES LSP1 RHOC SLC4A7 TNNT3
Forced vital capacity (FVC), Best measure 1.36 2 0 0.0 0.00 1.0e+00 ACP2 RHOC
Body fat percentage 2.47 4 3 6.7 0.21 7.9e-01 ALDOA HOXA10 SLC4A7 ZNF48
Leg fat percentage (right) 2.23 4 2 4.4 0.63 3.7e-01 ALDOA HOXA10 PDLIM4 ZNF48
Arm fat-free mass (right) 4.15 7 3 6.7 0.44 3.3e-01 ALDOA ARHGAP42 ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Comparative body size at age 10 3.79 4 4 8.9 1.00 4.8e-03 ALDOA ERI1 NEIL2 ZNF48
Worry too long after embarrassment 2.29 1 1 2.2 0.00 1.0e+00 ERI1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.15 1 0 0.0 0.00 1.0e+00 ALDOA
Wheeze or whistling in the chest in last year 1.88 1 0 0.0 0.00 1.0e+00 ALDOA
Number of children fathered 1.41 1 0 0.0 0.00 1.0e+00 ALDOA
Age at first live birth 1.33 1 0 0.0 0.00 1.0e+00 NEIL2
Pulse wave peak to peak time 2.11 2 0 0.0 0.00 1.0e+00 FES NEIL2
Qualifications: College or University degree 1.40 2 0 0.0 0.00 1.0e+00 ALDOA ZNF48
Neck or shoulder pain in last month 1.43 1 0 0.0 0.00 1.0e+00 ALDOA
Medication: Blood pressure 16.99 15 9 20.0 0.95 7.5e-08 ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 PDLIM4 PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3
Angina (self-reported) 3.80 1 1 2.2 0.00 1.0e+00 FES
Medication: Seretide 50 evohaler 1.58 1 0 0.0 0.00 1.0e+00 PDLIM4
Mean time to correctly identify matches 1.20 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 2.10 1 0 0.0 0.00 1.0e+00 FES
Whole body fat mass 3.25 4 2 4.4 0.57 4.3e-01 ALDOA ERI1 HOXA10 ZNF48
Leg fat mass (right) 3.14 4 2 4.4 0.62 3.8e-01 ALDOA ERI1 HOXA10 ZNF48
Arm predicted mass (right) 4.18 6 3 6.7 0.53 2.8e-01 ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Pulse rate, automated reading 1.52 2 0 0.0 0.00 1.0e+00 ACP2 SLC4A7
Alcohol intake frequency. 2.46 2 2 4.4 0.00 1.0e+00 ALDOA ZNF48
Comparative height size at age 10 2.54 4 2 4.4 -0.40 6.0e-01 ACP2 ALDOA FES PDLIM4
Suffer from 'nerves' 2.31 2 0 0.0 0.00 1.0e+00 ERI1 NEIL2
Age at last live birth 1.97 2 0 0.0 0.00 1.0e+00 ERI1 NEIL2
Qualifications: NVQ or HND or HNC or equivalent 1.91 1 0 0.0 0.00 1.0e+00 ALDOA
Medication: Aspirin 4.43 2 1 2.2 0.00 1.0e+00 FES PIGV
Hypertension (Self-reported) 23.07 19 16 35.6 0.95 5.7e-10 ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Illnesses of father: Heart disease 3.37 1 1 2.2 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), predicted 2.32 2 1 2.2 0.00 1.0e+00 MGRN1 PDLIM4
Whole body fat-free mass 4.31 8 3 6.7 0.34 4.1e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 SLC4A7 ZNF48
Leg fat-free mass (right) 4.43 7 3 6.7 0.32 4.9e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Arm fat percentage (left) 2.95 4 3 6.7 0.53 4.7e-01 ALDOA ERI1 HOXA10 ZNF48
Average weekly red wine intake 1.26 1 0 0.0 0.00 1.0e+00 ULK3
Handedness (chirality/laterality): Left-handed 1.20 1 0 0.0 0.00 1.0e+00 FES
Mood swings 2.20 3 0 0.0 0.00 1.0e+00 ACP2 ERI1 NEIL2
Diabetes diagnosed by doctor 1.38 1 0 0.0 0.00 1.0e+00 PIGV
Mouth/teeth dental problems: Mouth ulcers 1.16 1 0 0.0 0.00 1.0e+00 SLC4A7
Medication for cholesterol 11.69 12 5 11.1 -0.98 8.7e-09 ARHGAP42 FES HOXA10 LSP1 MGRN1 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ZNF48
Mineral and other dietary supplements 1.76 1 0 0.0 0.00 1.0e+00 FES
Breast cancer (self-reported) 2.85 1 0 0.0 0.00 1.0e+00 SLC4A7
Asthma (self-reported) 3.42 1 1 2.2 0.00 1.0e+00 PDLIM4
Osteoarthritis (self-reported) 1.49 1 0 0.0 0.00 1.0e+00 PDLIM4
Medication: Aspirin 4.51 2 1 2.2 0.00 1.0e+00 FES PIGV
Illnesses of father: None of the above (group 1) 3.90 1 1 2.2 0.00 1.0e+00 FES
Smoking status: Current 1.74 1 0 0.0 0.00 1.0e+00 ERI1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.07 3 0 0.0 0.00 1.0e+00 ALDOA NEIL2 ZNF48
Whole body water mass 4.35 8 3 6.7 0.34 4.2e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 SLC4A7 ZNF48
Leg predicted mass (right) 4.43 7 3 6.7 0.32 4.9e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Arm fat mass (left) 3.83 5 2 4.4 0.60 2.9e-01 ALDOA ERI1 HOXA10 NEIL2 ZNF48
Number of self-reported non-cancer illnesses 3.87 2 0 0.0 0.00 1.0e+00 MGRN1 PDLIM4
Miserableness 2.70 3 1 2.2 0.00 1.0e+00 ACP2 ERI1 NEIL2
Guilty feelings 2.61 3 0 0.0 0.00 1.0e+00 ACP2 ERI1 NEIL2
Eye problems/disorders: Glaucoma 1.25 1 0 0.0 0.00 1.0e+00 ACP2
Medication: Blood pressure 21.41 19 12 26.7 0.97 1.7e-11 ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Supplements: Fish oil (including cod liver oil) 1.71 1 0 0.0 0.00 1.0e+00 ERI1
High cholesterol (Self-reported) 3.55 3 1 2.2 0.00 1.0e+00 ARHGAP42 FES PIGV
Medication: Lisinopril 6.95 8 0 0.0 0.99 2.8e-06 ACP2 ARHGAP42 FES LSP1 RHOC SLC4A7 TNNI2 ULK3
Illnesses of father: High blood pressure 7.37 7 1 2.2 0.92 3.2e-03 ACP2 ARHGAP42 FES LSP1 PLCB1 SLC4A7 TNNI2
Ever smoked 0.90 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 4.45 7 3 6.7 0.42 3.4e-01 ALDOA ARHGAP42 ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Leg fat percentage (left) 2.62 4 2 4.4 0.96 4.1e-02 ALDOA ERI1 PDLIM4 ZNF48
Arm fat-free mass (left) 4.29 6 3 6.7 0.54 2.7e-01 ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Average weekly beer plus cider intake 1.54 1 0 0.0 0.00 1.0e+00 ERI1
Irritability 3.02 2 1 2.2 0.00 1.0e+00 ERI1 NEIL2
Risk taking 1.59 2 0 0.0 0.00 1.0e+00 ERI1 FES
Diastolic blood pressure, automated reading 12.62 15 9 20.0 0.91 3.2e-06 ACP2 ARHGAP42 ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV RHOC TNNI2 TNNT3 ULK3 ZNF48
Myopia 1.25 1 0 0.0 0.00 1.0e+00 RHOC
Vascular/heart problems diagnosed by doctor 22.10 19 15 33.3 -0.94 2.7e-09 ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Cholesterol lowering medication 2.82 3 0 0.0 0.00 1.0e+00 MGRN1 PIGV ZNF48
Heart attack/myocardial infarction (self-reported) 1.92 1 1 2.2 0.00 1.0e+00 FES
Heart disease (siblings) 1.67 1 0 0.0 0.00 1.0e+00 FES
Impedance of whole body 4.71 9 4 8.9 -0.78 1.4e-02 ALDOA ARHGAP42 ERI1 LSP1 NEIL2 SLC4A7 TNNI2 TNNT3 ZNF48
Leg fat mass (left) 3.36 4 2 4.4 0.64 3.6e-01 ALDOA ERI1 HOXA10 ZNF48
Arm predicted mass (left) 4.44 6 3 6.7 0.54 2.7e-01 ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.5
GTEx Adipose Visceral Omentum 1 0.049 1.6
GTEx Adrenal Gland 0 0.000 1.6
GTEx Artery Aorta 2 0.067 1.6
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 3 0.080 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.6
GTEx Brain Cerebellar Hemisphere 0 0.000 1.5
GTEx Brain Cerebellum 0 0.000 1.5
GTEx Brain Cortex 0 0.000 1.5
GTEx Brain Frontal Cortex BA9 0 0.000 1.6
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.5
GTEx Brain Putamen basal ganglia 0 0.000 1.5
GTEx Breast Mammary Tissue 0 0.000 1.6
GTEx Breast Mammary Tissue (Male) 1 0.084 1.5
GTEx Breast Mammary Tissue (Female) 0 0.000 1.5
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.6
GTEx Cells Transformed fibroblasts 4 0.095 1.6
GTEx Colon Sigmoid 0 0.000 1.5
GTEx Colon Transverse 0 0.000 1.6
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.5
GTEx Esophagus Mucosa 0 0.000 1.6
GTEx Esophagus Muscularis 2 0.062 1.6
GTEx Heart Atrial Appendage 0 0.000 1.6
GTEx Heart Left Ventricle 1 0.065 1.5
GTEx Liver 0 0.000 1.5
GTEx Lung 1 0.035 1.5
GTEx Muscle Skeletal 3 0.104 1.5
GTEx Nerve Tibial 2 0.046 1.5
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 1 0.061 1.5
GTEx Pituitary 0 0.000 1.5
GTEx Prostate 0 0.000 1.6
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.6
GTEx Skin Sun Exposed Lower leg 1 0.027 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.7
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 1 0.032 1.5
GTEx Thyroid 4 0.100 1.5
GTEx Uterus 0 0.000 1.5
GTEx Vagina 1 0.157 1.5
GTEx Whole Blood 0 0.000 1.6
METSIM Adipose 3 0.065 1.5
NTR Blood 1 0.042 1.5
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.6
YFS Blood 2 0.043 1.4
CommonMind Brain Pre-frontal Cortex 2 0.037 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.091 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.5
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.6
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.049 1.5
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 3 0.188 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.6
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 2 0.039 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.5