Hub : Traits :

Medication: Bendroflumethiazide

59 significantly associated models · 38 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	26428864	27820430	1	1	3.0e-07	1.4e-06	6.9e-03	69	PIGV
2	1	112312154	113907148	4	2	8.0e-11	9.4e-10	4.6e-05	56	CTTNBP2NL RHOC
3	3	26720690	28211713	1	1	1.7e-07	2.1e-08	4.1e-02	87	SLC4A7
4	5	130830617	132304222	2	1	3.1e-08	1.6e-07	1.0e+00	100	PDLIM4
5	7	26969253	27533292	2	1	1.2e-10	6.1e-14	1.1e-04	74	HOXA10
6	8	8092025	9669775	2	1	6.7e-09	1.2e-08	8.6e-03	79	ERI1
7	8	10056664	11891593	6	1	9.5e-09	1.6e-08	5.7e-04	63	NEIL2
8	11	1213806	2640824	3	3	3.5e-15	3.6e-16	5.7e-02	94	LSP1 TNNI2 TNNT3
9	11	46570859	47977454	2	1	6.1e-09	1.4e-06	5.6e-01	98	ACP2
10	11	99859184	101559718	2	1	1.6e-07	8.5e-08	1.0e+00	100	ARHGAP42
11	15	74042497	75930199	4	1	2.7e-08	7.7e-08	1.0e+00	100	ULK3
12	15	90730363	92135418	1	1	8.3e-08	1.8e-07	3.3e-01	96	FES
13	16	3969463	5433992	1	1	9.8e-08	1.6e-05	8.8e-02	84	MGRN1
14	16	29711343	31102321	5	2	1.0e-09	5.2e-07	4.5e-01	98	ALDOA ZNF48
15	20	7847156	9112333	1	1	2.2e-07	2.9e-10	3.2e-04	68	PLCB1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder (2018)	1.54	2	0	0.0	0.00	1.0e+00	FES ULK3
Bipolar Disorder or Schizophrenia	3.05	3	2	4.4	0.00	1.0e+00	ALDOA ERI1 FES
Depressed Affect (Nagel 2018)	1.32	1	1	2.2	0.00	1.0e+00	ACP2
Neuroticism (Nagel 2018)	1.38	2	1	2.2	0.00	1.0e+00	ACP2 FES
Schizophrenia (2018)	3.09	3	1	2.2	0.00	1.0e+00	ALDOA ERI1 FES
Worry (Nagel 2018)	1.56	2	0	0.0	0.00	1.0e+00	ALDOA ZNF48
Alzheimer’s Disease (including proxy)	1.15	1	0	0.0	0.00	1.0e+00	ZNF48
Crohns Disease (2017)	2.72	1	1	2.2	0.00	1.0e+00	PDLIM4
Irritable Bowel Disease (IBD)	2.83	3	1	2.2	0.00	1.0e+00	LSP1 PDLIM4 TNNI2
Ulcerative Colitis (UC)	2.30	1	1	2.2	0.00	1.0e+00	TNNI2
Breast Cancer	8.44	6	3	6.7	0.62	1.9e-01	FES LSP1 PDLIM4 SLC4A7 TNNT3 ULK3
Prostate Cancer	1.67	1	0	0.0	0.00	1.0e+00	HOXA10
Crohns Disease (2012)	2.09	1	1	2.2	0.00	1.0e+00	PDLIM4
Mean Putamen Volume	1.61	1	0	0.0	0.00	1.0e+00	NEIL2
Fasting Glucose	3.12	1	1	2.2	0.00	1.0e+00	ACP2
HDL Cholesterol	2.63	2	1	2.2	0.00	1.0e+00	ACP2 PIGV
Lupus	2.29	1	0	0.0	0.00	1.0e+00	ERI1
Neuroticism (2016)	3.17	2	2	4.4	0.00	1.0e+00	ERI1 NEIL2
Schizophrenia (2014)	2.90	3	1	2.2	0.00	1.0e+00	ALDOA ERI1 FES
Triglycerides	2.93	3	0	0.0	0.00	1.0e+00	ERI1 NEIL2 PDLIM4
Ulcerative Colitis	3.31	1	0	0.0	0.00	1.0e+00	TNNI2
Blood Eosinophil Count	7.97	4	3	6.7	0.36	6.4e-01	ALDOA PDLIM4 PIGV ZNF48
Blood Platelet Count	2.44	11	5	11.1	0.09	8.0e-01	ALDOA ARHGAP42 CTTNBP2NL MGRN1 PDLIM4 PIGV RHOC SLC4A7 TNNI2 ULK3 ZNF48
Blood Red Count	2.24	9	2	4.4	-0.34	3.7e-01	ALDOA FES LSP1 MGRN1 PLCB1 RHOC TNNI2 ULK3 ZNF48
Blood White Count	3.56	8	3	6.7	0.27	5.2e-01	ALDOA ARHGAP42 FES MGRN1 PDLIM4 PLCB1 TNNI2 ZNF48
Heel T-Score	2.10	8	5	11.1	-0.55	1.5e-01	ACP2 ALDOA ARHGAP42 CTTNBP2NL HOXA10 RHOC SLC4A7 ZNF48
BMI	2.77	3	2	4.4	0.00	1.0e+00	ALDOA ULK3 ZNF48
Height	2.76	14	8	17.8	-0.44	1.2e-01	ACP2 ALDOA ARHGAP42 FES HOXA10 LSP1 MGRN1 PDLIM4 PIGV RHOC SLC4A7 TNNI2 TNNT3 ZNF48
Waist Hip Ratio (WHR)	0.90	2	0	0.0	0.00	1.0e+00	TNNT3 ULK3
Systolic Blood Pressure	21.72	14	14	31.1	0.95	2.3e-07	ACP2 ARHGAP42 CTTNBP2NL FES HOXA10 LSP1 MGRN1 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3
Smoking Status	0.97	1	0	0.0	0.00	1.0e+00	FES
Allergy or Eczema	2.21	3	1	2.2	0.00	1.0e+00	FES PDLIM4 ULK3
Cardiovascular Disease	17.22	17	14	31.1	0.95	8.5e-09	ACP2 ALDOA ARHGAP42 CTTNBP2NL FES HOXA10 LSP1 MGRN1 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Respiratory disease	3.06	2	1	2.2	0.00	1.0e+00	FES PDLIM4
Type 2 Diabetes (T2D) (2018)	1.27	1	0	0.0	0.00	1.0e+00	ALDOA
Lung FEV1/FVC ratio	1.54	5	3	6.7	-0.61	2.8e-01	ALDOA ARHGAP42 CTTNBP2NL PDLIM4 ZNF48
Lung FVC	1.62	4	2	4.4	0.59	4.1e-01	CTTNBP2NL HOXA10 PDLIM4 ZNF48
Neuroticism	1.20	1	0	0.0	0.00	1.0e+00	ACP2
Chronotype (morning person)	1.31	2	0	0.0	0.00	1.0e+00	ACP2 ALDOA
Hair Pigment	0.22	3	2	4.4	0.00	1.0e+00	ACP2 ARHGAP42 FES
Tanning	0.21	1	0	0.0	0.00	1.0e+00	ULK3
Hand grip strength (left)	3.44	6	2	4.4	-0.34	5.0e-01	ALDOA FES MGRN1 PDLIM4 RHOC ZNF48
Number of treatments/medications taken	4.72	7	0	0.0	0.98	5.3e-05	ARHGAP42 FES MGRN1 PDLIM4 RHOC SLC4A7 ZNF48
Sensitivity / hurt feelings	2.99	2	2	4.4	0.00	1.0e+00	ERI1 FES
Frequency of depressed mood in last 2 weeks	1.55	1	0	0.0	0.00	1.0e+00	NEIL2
Systolic blood pressure, automated reading	15.67	14	11	24.4	0.94	7.7e-07	ACP2 ARHGAP42 ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PIGV RHOC SLC4A7 TNNI2 TNNT3 ULK3
Angina	3.79	2	1	2.2	0.00	1.0e+00	ARHGAP42 FES
Diabetes (father)	1.77	1	0	0.0	0.00	1.0e+00	ALDOA
Diabetes (mother)	1.86	1	0	0.0	0.00	1.0e+00	ZNF48
Impedance of leg (right)	4.52	7	5	11.1	-0.76	4.8e-02	ALDOA ARHGAP42 ERI1 FES NEIL2 RHOC ZNF48
Leg fat-free mass (left)	4.34	7	3	6.7	0.31	5.0e-01	ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Trunk fat percentage	2.37	5	3	6.7	0.01	9.9e-01	ALDOA HOXA10 SLC4A7 TNNT3 ZNF48
Hand grip strength (right)	3.19	4	1	2.2	-0.22	7.8e-01	ALDOA PDLIM4 RHOC ZNF48
Current tobacco smoking	1.78	1	0	0.0	0.00	1.0e+00	ERI1
Fed-up feelings	2.21	3	0	0.0	0.00	1.0e+00	ACP2 ERI1 NEIL2
Age when periods started (menarche)	2.53	3	1	2.2	0.00	1.0e+00	ALDOA TNNI2 TNNT3
Heel bone mineral density (BMD) T-score, automated (left)	3.86	4	2	4.4	0.45	5.5e-01	ACP2 ARHGAP42 ERI1 NEIL2
High blood pressure	23.09	19	16	35.6	0.95	4.5e-10	ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Hayfever, allergic rhinitis or eczema	2.32	3	1	2.2	0.00	1.0e+00	FES PDLIM4 ULK3
Supplements: Glucosamine	1.70	1	0	0.0	0.00	1.0e+00	ULK3
Medication: Atenolol	8.15	5	1	2.2	0.97	6.7e-03	ARHGAP42 FES RHOC TNNT3 ULK3
Medication: Levothyroxine sodium	1.50	1	0	0.0	0.00	1.0e+00	ERI1
Sitting height	1.52	4	1	2.2	-0.98	2.4e-02	FES NEIL2 PDLIM4 SLC4A7
High blood pressure (mother)	10.64	8	1	2.2	0.91	1.4e-03	ACP2 ARHGAP42 FES HOXA10 LSP1 RHOC SLC4A7 TNNT3
Body mass index (BMI)	4.00	4	3	6.7	0.99	8.6e-03	ALDOA ERI1 NEIL2 ZNF48
Impedance of leg (left)	4.35	7	5	11.1	-0.75	5.4e-02	ALDOA ARHGAP42 ERI1 FES NEIL2 RHOC ZNF48
Leg predicted mass (left)	4.35	7	3	6.7	0.31	4.9e-01	ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Trunk fat mass	3.03	3	2	4.4	0.00	1.0e+00	ALDOA HOXA10 ZNF48
Waist circumference	4.18	3	2	4.4	0.00	1.0e+00	ALDOA ULK3 ZNF48
Number of incorrect matches in round	3.03	2	1	2.2	0.00	1.0e+00	ALDOA FES
Alcohol usually taken with meals	1.82	1	0	0.0	0.00	1.0e+00	FES
Nervous feelings	3.53	5	1	2.2	-0.68	2.1e-01	ACP2 ALDOA ERI1 NEIL2 ZNF48
Frequency of tenseness / restlessness in last 2 weeks	1.58	1	0	0.0	0.00	1.0e+00	ZNF48
Hearing difficulty/problems with background noise	1.96	1	0	0.0	0.00	1.0e+00	ULK3
Forced vital capacity (FVC)	1.66	3	1	2.2	0.00	1.0e+00	ACP2 ARHGAP42 RHOC
Heel bone mineral density (BMD) T-score, automated (right)	3.79	4	2	4.4	0.24	7.6e-01	ACP2 ARHGAP42 ERI1 NEIL2
Mouth/teeth dental problems	2.22	1	0	0.0	0.00	1.0e+00	ERI1
Heart attack	2.02	1	1	2.2	0.00	1.0e+00	FES
Allergy	2.55	2	1	2.2	0.00	1.0e+00	FES PDLIM4
Medication: Ramipril	8.51	7	1	2.2	0.97	2.8e-04	ACP2 ARHGAP42 FES HOXA10 LSP1 TNNT3 ULK3
Medication: Simvastatin	3.90	3	1	2.2	0.00	1.0e+00	ARHGAP42 FES PIGV
Illnesses of siblings	4.43	3	1	2.2	0.00	1.0e+00	ARHGAP42 FES RHOC
Neuroticism score	3.21	3	2	4.4	0.00	1.0e+00	ACP2 ERI1 NEIL2
Weight	4.36	5	2	4.4	0.61	2.8e-01	ALDOA ERI1 NEIL2 PDLIM4 ZNF48
Impedance of arm (right)	4.37	9	4	8.9	-0.92	4.5e-04	ALDOA ERI1 HOXA10 LSP1 NEIL2 SLC4A7 TNNI2 TNNT3 ZNF48
Arm fat percentage (right)	3.10	4	3	6.7	0.50	5.0e-01	ALDOA ERI1 HOXA10 ZNF48
Trunk fat-free mass	4.02	7	3	6.7	0.25	5.9e-01	ACP2 ALDOA ARHGAP42 NEIL2 PDLIM4 SLC4A7 ZNF48
Hip circumference	3.51	3	2	4.4	0.00	1.0e+00	ALDOA ERI1 ZNF48
Alcohol intake versus 10 years previously	1.26	1	0	0.0	0.00	1.0e+00	ALDOA
Father's age at death	3.75	4	1	2.2	-0.99	1.2e-02	ERI1 FES PDLIM4 ULK3
Worrier / anxious feelings	4.05	2	2	4.4	0.00	1.0e+00	ERI1 NEIL2
Forced expiratory volume in 1-second (FEV1)	1.87	4	0	0.0	-0.99	7.0e-03	ARHGAP42 ERI1 PDLIM4 RHOC
Qualifications: A levels/AS levels or equivalent	1.21	1	0	0.0	0.00	1.0e+00	ULK3
Mouth/teeth dental problems: Dentures	2.44	2	0	0.0	0.00	1.0e+00	ALDOA ERI1
Asthma	3.53	1	1	2.2	0.00	1.0e+00	PDLIM4
Medication: Ibuprofen (e.g. Nurofen)	1.33	1	0	0.0	0.00	1.0e+00	ULK3
Medication: Cholesterol lowering	4.08	3	1	2.2	0.00	1.0e+00	ARHGAP42 FES PIGV
Illnesses of mother	6.97	5	1	2.2	-0.91	3.1e-02	ARHGAP42 FES HOXA10 LSP1 SLC4A7
Forced expiratory volume in 1-second (FEV1), Best measure	1.88	6	0	0.0	-1.00	3.2e-05	ACP2 ARHGAP42 ERI1 PDLIM4 RHOC ZNF48
Pulse wave Arterial Stiffness index	1.89	1	0	0.0	0.00	1.0e+00	FES
Impedance of arm (left)	4.36	9	5	11.1	-0.91	5.9e-04	ALDOA ERI1 HOXA10 LSP1 NEIL2 SLC4A7 TNNI2 TNNT3 ZNF48
Arm fat mass (right)	3.98	5	2	4.4	0.59	2.9e-01	ALDOA ERI1 HOXA10 NEIL2 ZNF48
Trunk predicted mass	4.00	7	3	6.7	0.25	5.9e-01	ACP2 ALDOA ARHGAP42 NEIL2 PDLIM4 SLC4A7 ZNF48
Standing height	2.71	8	4	8.9	-0.51	1.9e-01	ACP2 ALDOA ERI1 LSP1 MGRN1 PDLIM4 RHOC SLC4A7
Breastfed as a baby	2.43	2	0	0.0	0.00	1.0e+00	FES PIGV
Tense / 'highly strung'	2.93	3	1	2.2	0.00	1.0e+00	ALDOA ERI1 NEIL2
Hair/balding pattern: Pattern 4	0.91	1	0	0.0	0.00	1.0e+00	FES
Birth weight of first child	4.68	3	1	2.2	0.00	1.0e+00	FES NEIL2 PDLIM4
Peak expiratory flow (PEF)	1.77	3	0	0.0	0.00	1.0e+00	ERI1 PDLIM4 ULK3
Pulse wave reflection index	1.63	1	0	0.0	0.00	1.0e+00	NEIL2
Ever highly irritable/argumentative for 2 days	2.46	1	0	0.0	0.00	1.0e+00	LSP1
Qualifications: O levels/GCSEs or equivalent	1.98	1	0	0.0	0.00	1.0e+00	ULK3
Mouth/teeth dental problems: Bleeding gums	1.56	1	0	0.0	0.00	1.0e+00	ACP2
Headache pain in last month	1.61	2	0	0.0	0.00	1.0e+00	ERI1 FES
Medication for cholesterol, blood pressure or diabetes	11.04	11	3	6.7	-0.91	1.2e-04	ACP2 ARHGAP42 CTTNBP2NL FES LSP1 PIGV PLCB1 RHOC SLC4A7 TNNI2 ULK3
Hypothyroidism/myxoedema (self-reported)	2.00	2	1	2.2	0.00	1.0e+00	ERI1 NEIL2
Medication: Amlodipine	13.88	11	6	13.3	0.98	2.2e-07	ACP2 ARHGAP42 CTTNBP2NL FES HOXA10 LSP1 MGRN1 RHOC SLC4A7 TNNI2 TNNT3
Medication: Ventolin 100micrograms inhaler	2.18	1	0	0.0	0.00	1.0e+00	PDLIM4
Birth weight	2.58	3	1	2.2	0.00	1.0e+00	FES HOXA10 PDLIM4
High blood pressure (siblings)	7.72	7	1	2.2	0.95	8.7e-04	ACP2 ARHGAP42 FES LSP1 RHOC SLC4A7 TNNT3
Forced vital capacity (FVC), Best measure	1.36	2	0	0.0	0.00	1.0e+00	ACP2 RHOC
Body fat percentage	2.47	4	3	6.7	0.21	7.9e-01	ALDOA HOXA10 SLC4A7 ZNF48
Leg fat percentage (right)	2.23	4	2	4.4	0.63	3.7e-01	ALDOA HOXA10 PDLIM4 ZNF48
Arm fat-free mass (right)	4.15	7	3	6.7	0.44	3.3e-01	ALDOA ARHGAP42 ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Comparative body size at age 10	3.79	4	4	8.9	1.00	4.8e-03	ALDOA ERI1 NEIL2 ZNF48
Worry too long after embarrassment	2.29	1	1	2.2	0.00	1.0e+00	ERI1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.15	1	0	0.0	0.00	1.0e+00	ALDOA
Wheeze or whistling in the chest in last year	1.88	1	0	0.0	0.00	1.0e+00	ALDOA
Number of children fathered	1.41	1	0	0.0	0.00	1.0e+00	ALDOA
Age at first live birth	1.33	1	0	0.0	0.00	1.0e+00	NEIL2
Pulse wave peak to peak time	2.11	2	0	0.0	0.00	1.0e+00	FES NEIL2
Qualifications: College or University degree	1.40	2	0	0.0	0.00	1.0e+00	ALDOA ZNF48
Neck or shoulder pain in last month	1.43	1	0	0.0	0.00	1.0e+00	ALDOA
Medication: Blood pressure	16.99	15	9	20.0	0.95	7.5e-08	ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 PDLIM4 PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3
Angina (self-reported)	3.80	1	1	2.2	0.00	1.0e+00	FES
Medication: Seretide 50 evohaler	1.58	1	0	0.0	0.00	1.0e+00	PDLIM4
Mean time to correctly identify matches	1.20	1	0	0.0	0.00	1.0e+00	FES
Heart disease (mother)	2.10	1	0	0.0	0.00	1.0e+00	FES
Whole body fat mass	3.25	4	2	4.4	0.57	4.3e-01	ALDOA ERI1 HOXA10 ZNF48
Leg fat mass (right)	3.14	4	2	4.4	0.62	3.8e-01	ALDOA ERI1 HOXA10 ZNF48
Arm predicted mass (right)	4.18	6	3	6.7	0.53	2.8e-01	ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Pulse rate, automated reading	1.52	2	0	0.0	0.00	1.0e+00	ACP2 SLC4A7
Alcohol intake frequency.	2.46	2	2	4.4	0.00	1.0e+00	ALDOA ZNF48
Comparative height size at age 10	2.54	4	2	4.4	-0.40	6.0e-01	ACP2 ALDOA FES PDLIM4
Suffer from 'nerves'	2.31	2	0	0.0	0.00	1.0e+00	ERI1 NEIL2
Age at last live birth	1.97	2	0	0.0	0.00	1.0e+00	ERI1 NEIL2
Qualifications: NVQ or HND or HNC or equivalent	1.91	1	0	0.0	0.00	1.0e+00	ALDOA
Medication: Aspirin	4.43	2	1	2.2	0.00	1.0e+00	FES PIGV
Hypertension (Self-reported)	23.07	19	16	35.6	0.95	5.7e-10	ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Illnesses of father: Heart disease	3.37	1	1	2.2	0.00	1.0e+00	FES
Forced expiratory volume in 1-second (FEV1), predicted	2.32	2	1	2.2	0.00	1.0e+00	MGRN1 PDLIM4
Whole body fat-free mass	4.31	8	3	6.7	0.34	4.1e-01	ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 SLC4A7 ZNF48
Leg fat-free mass (right)	4.43	7	3	6.7	0.32	4.9e-01	ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Arm fat percentage (left)	2.95	4	3	6.7	0.53	4.7e-01	ALDOA ERI1 HOXA10 ZNF48
Average weekly red wine intake	1.26	1	0	0.0	0.00	1.0e+00	ULK3
Handedness (chirality/laterality): Left-handed	1.20	1	0	0.0	0.00	1.0e+00	FES
Mood swings	2.20	3	0	0.0	0.00	1.0e+00	ACP2 ERI1 NEIL2
Diabetes diagnosed by doctor	1.38	1	0	0.0	0.00	1.0e+00	PIGV
Mouth/teeth dental problems: Mouth ulcers	1.16	1	0	0.0	0.00	1.0e+00	SLC4A7
Medication for cholesterol	11.69	12	5	11.1	-0.98	8.7e-09	ARHGAP42 FES HOXA10 LSP1 MGRN1 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ZNF48
Mineral and other dietary supplements	1.76	1	0	0.0	0.00	1.0e+00	FES
Breast cancer (self-reported)	2.85	1	0	0.0	0.00	1.0e+00	SLC4A7
Asthma (self-reported)	3.42	1	1	2.2	0.00	1.0e+00	PDLIM4
Osteoarthritis (self-reported)	1.49	1	0	0.0	0.00	1.0e+00	PDLIM4
Medication: Aspirin	4.51	2	1	2.2	0.00	1.0e+00	FES PIGV
Illnesses of father: None of the above (group 1)	3.90	1	1	2.2	0.00	1.0e+00	FES
Smoking status: Current	1.74	1	0	0.0	0.00	1.0e+00	ERI1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.07	3	0	0.0	0.00	1.0e+00	ALDOA NEIL2 ZNF48
Whole body water mass	4.35	8	3	6.7	0.34	4.2e-01	ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 SLC4A7 ZNF48
Leg predicted mass (right)	4.43	7	3	6.7	0.32	4.9e-01	ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Arm fat mass (left)	3.83	5	2	4.4	0.60	2.9e-01	ALDOA ERI1 HOXA10 NEIL2 ZNF48
Number of self-reported non-cancer illnesses	3.87	2	0	0.0	0.00	1.0e+00	MGRN1 PDLIM4
Miserableness	2.70	3	1	2.2	0.00	1.0e+00	ACP2 ERI1 NEIL2
Guilty feelings	2.61	3	0	0.0	0.00	1.0e+00	ACP2 ERI1 NEIL2
Eye problems/disorders: Glaucoma	1.25	1	0	0.0	0.00	1.0e+00	ACP2
Medication: Blood pressure	21.41	19	12	26.7	0.97	1.7e-11	ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Supplements: Fish oil (including cod liver oil)	1.71	1	0	0.0	0.00	1.0e+00	ERI1
High cholesterol (Self-reported)	3.55	3	1	2.2	0.00	1.0e+00	ARHGAP42 FES PIGV
Medication: Lisinopril	6.95	8	0	0.0	0.99	2.8e-06	ACP2 ARHGAP42 FES LSP1 RHOC SLC4A7 TNNI2 ULK3
Illnesses of father: High blood pressure	7.37	7	1	2.2	0.92	3.2e-03	ACP2 ARHGAP42 FES LSP1 PLCB1 SLC4A7 TNNI2
Ever smoked	0.90	1	0	0.0	0.00	1.0e+00	FES
Basal metabolic rate	4.45	7	3	6.7	0.42	3.4e-01	ALDOA ARHGAP42 ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Leg fat percentage (left)	2.62	4	2	4.4	0.96	4.1e-02	ALDOA ERI1 PDLIM4 ZNF48
Arm fat-free mass (left)	4.29	6	3	6.7	0.54	2.7e-01	ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Average weekly beer plus cider intake	1.54	1	0	0.0	0.00	1.0e+00	ERI1
Irritability	3.02	2	1	2.2	0.00	1.0e+00	ERI1 NEIL2
Risk taking	1.59	2	0	0.0	0.00	1.0e+00	ERI1 FES
Diastolic blood pressure, automated reading	12.62	15	9	20.0	0.91	3.2e-06	ACP2 ARHGAP42 ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV RHOC TNNI2 TNNT3 ULK3 ZNF48
Myopia	1.25	1	0	0.0	0.00	1.0e+00	RHOC
Vascular/heart problems diagnosed by doctor	22.10	19	15	33.3	-0.94	2.7e-09	ACP2 ALDOA ARHGAP42 CTTNBP2NL ERI1 FES HOXA10 LSP1 MGRN1 NEIL2 PDLIM4 PIGV PLCB1 RHOC SLC4A7 TNNI2 TNNT3 ULK3 ZNF48
Cholesterol lowering medication	2.82	3	0	0.0	0.00	1.0e+00	MGRN1 PIGV ZNF48
Heart attack/myocardial infarction (self-reported)	1.92	1	1	2.2	0.00	1.0e+00	FES
Heart disease (siblings)	1.67	1	0	0.0	0.00	1.0e+00	FES
Impedance of whole body	4.71	9	4	8.9	-0.78	1.4e-02	ALDOA ARHGAP42 ERI1 LSP1 NEIL2 SLC4A7 TNNI2 TNNT3 ZNF48
Leg fat mass (left)	3.36	4	2	4.4	0.64	3.6e-01	ALDOA ERI1 HOXA10 ZNF48
Arm predicted mass (left)	4.44	6	3	6.7	0.54	2.7e-01	ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.5
GTEx	Adipose Visceral Omentum	1	0.049	1.6
GTEx	Adrenal Gland	0	0.000	1.6
GTEx	Artery Aorta	2	0.067	1.6
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	3	0.080	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.5
GTEx	Brain Cerebellum	0	0.000	1.5
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.6
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Brain Putamen basal ganglia	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.6
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.6
GTEx	Cells Transformed fibroblasts	4	0.095	1.6
GTEx	Colon Sigmoid	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.6
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Esophagus Mucosa	0	0.000	1.6
GTEx	Esophagus Muscularis	2	0.062	1.6
GTEx	Heart Atrial Appendage	0	0.000	1.6
GTEx	Heart Left Ventricle	1	0.065	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Lung	1	0.035	1.5
GTEx	Muscle Skeletal	3	0.104	1.5
GTEx	Nerve Tibial	2	0.046	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Pancreas	1	0.061	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.6
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.6
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.6
GTEx	Small Intestine Terminal Ileum	0	0.000	1.7
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Testis	1	0.032	1.5
GTEx	Thyroid	4	0.100	1.5
GTEx	Uterus	0	0.000	1.5
GTEx	Vagina	1	0.157	1.5
GTEx	Whole Blood	0	0.000	1.6
METSIM	Adipose	3	0.065	1.5
NTR	Blood	1	0.042	1.5
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.6
YFS	Blood	2	0.043	1.4
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.049	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	3	0.188	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.6
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5