Best TWAS P=4.54e-75 · Best GWAS P=1.03e-74 conditioned to 0.233
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | 18.2 | -18.3 | 4.5e-75 | -0.93 | 0.03 | 0.97 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | HEY2 | 0.15 | 0.20 | lasso | 10 | 0.21 | 6.7e-25 | -6.9 | -6.9 | 6.9e-12 | -0.09 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Coronary | TPD52L1 | 0.31 | -0.01 | enet | 19 | 0.05 | 7.0e-03 | -1.2 | -6.3 | 3.9e-10 | -0.19 | 0.03 | 0.54 | FALSE |
| 4 | GTEx | Esophagus Muscularis | HINT3 | 0.08 | 0.00 | enet | 14 | 0.00 | 2.9e-01 | 6.5 | -6.0 | 2.0e-09 | -0.13 | 0.07 | 0.04 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | CENPW | 0.17 | 0.01 | enet | 15 | 0.06 | 1.8e-03 | 17.9 | -10.4 | 2.3e-25 | -0.66 | 0.04 | 0.41 | FALSE |
| 6 | GTEx | Pancreas | HEY2 | 0.28 | 0.11 | lasso | 3 | 0.10 | 3.5e-05 | -5.3 | -5.8 | 8.0e-09 | -0.07 | 0.10 | 0.90 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | HINT3 | 0.08 | 0.01 | lasso | 4 | 0.03 | 2.0e-03 | -5.2 | -6.6 | 3.4e-11 | -0.22 | 0.22 | 0.14 | FALSE |
| 8 | GTEx | Testis | HEY2 | 0.31 | 0.17 | lasso | 5 | 0.19 | 7.4e-09 | -6.7 | -6.7 | 2.2e-11 | -0.10 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Thyroid | HEY2 | 0.22 | 0.24 | lasso | 6 | 0.23 | 1.0e-17 | -6.7 | -6.9 | 5.4e-12 | -0.10 | 0.01 | 0.99 | TRUE |
| 10 | GTEx | Vagina | CENPW | 0.24 | -0.01 | lasso | 8 | -0.01 | 7.9e-01 | 4.9 | 6.4 | 1.3e-10 | 0.39 | 0.04 | 0.07 | FALSE |
| 11 | METSIM | Adipose | CENPW | 0.02 | 0.02 | blup | 189 | 0.01 | 8.3e-03 | 17.9 | -12.5 | 4.0e-36 | -0.71 | 0.03 | 0.65 | FALSE |
| 12 | METSIM | Adipose | HEY2 | 0.02 | 0.04 | lasso | 1 | 0.02 | 1.6e-04 | -5.1 | -5.2 | 2.7e-07 | -0.06 | 0.02 | 0.97 | FALSE |
| 13 | METSIM | Adipose | NCOA7 | 0.05 | 0.05 | enet | 5 | 0.05 | 1.9e-07 | 5.6 | 8.7 | 3.0e-18 | 0.25 | 0.95 | 0.03 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | HEY2 | 0.10 | 0.12 | enet | 15 | 0.13 | 9.8e-17 | 6.3 | -6.3 | 2.4e-10 | -0.08 | 0.02 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HINT3 | 0.04 | 0.02 | enet | 7 | 0.02 | 2.6e-05 | -4.4 | -5.8 | 8.2e-09 | -0.01 | 0.38 | 0.52 | TRUE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRMT11 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.3e-07 | -5.2 | 5.2 | 1.9e-07 | 0.25 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | 17.9 | -17.1 | 9.7e-66 | -0.90 | 0.02 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | 17.8 | -17.1 | 1.5e-65 | -0.91 | 0.03 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | HEY2 | 0.03 | 0.04 | lasso | 3 | 0.02 | 3.8e-03 | 5.3 | -5.6 | 2.0e-08 | -0.10 | 0.01 | 0.98 | FALSE |