Best TWAS P=1.64e-26 · Best GWAS P=1.06e-39 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FRK | 0.06 | 0.06 | lasso | 2 | 0.05 | 6.1e-07 | 6.61 | 6.7 | 2.1e-11 | -0.03 | 0.96 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | TSPYL1 | 0.13 | 0.07 | lasso | 2 | 0.05 | 6.0e-05 | -2.99 | -6.5 | 6.1e-11 | 0.04 | 0.06 | 0.87 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | RP1-93H18.7 | 0.11 | 0.08 | lasso | 3 | 0.08 | 8.1e-07 | -9.33 | -9.4 | 4.0e-21 | 0.02 | 0.97 | 0.01 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | FAM26F | 0.15 | 0.05 | enet | 17 | 0.11 | 3.9e-06 | 5.33 | 5.6 | 2.3e-08 | -0.04 | 0.16 | 0.72 | FALSE |
| 5 | GTEx | Artery Aorta | NT5DC1 | 0.23 | 0.08 | lasso | 10 | 0.08 | 4.6e-05 | 3.69 | 5.9 | 4.6e-09 | 0.05 | 0.84 | 0.03 | TRUE |
| 6 | GTEx | Artery Aorta | RP3-486I3.4 | 0.10 | 0.03 | enet | 23 | 0.03 | 6.1e-03 | 4.94 | 5.5 | 2.9e-08 | 0.02 | 0.14 | 0.50 | FALSE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | FRK | 0.12 | 0.07 | enet | 12 | 0.09 | 8.1e-04 | -5.00 | -6.1 | 1.2e-09 | -0.09 | 0.34 | 0.08 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | DSE | 0.13 | 0.09 | lasso | 4 | 0.03 | 3.0e-02 | 6.36 | 8.3 | 8.1e-17 | 0.02 | 0.05 | 0.80 | FALSE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | FAM26F | 0.34 | 0.10 | enet | 32 | 0.32 | 5.8e-11 | 6.80 | 10.4 | 2.4e-25 | 0.00 | 0.83 | 0.13 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | DSE | 0.07 | 0.01 | enet | 7 | 0.01 | 4.1e-02 | -9.17 | -10.5 | 1.2e-25 | 0.05 | 0.42 | 0.31 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | NT5DC1 | 0.07 | 0.03 | enet | 9 | 0.05 | 9.8e-05 | 3.39 | -7.1 | 1.2e-12 | -0.07 | 0.15 | 0.54 | TRUE |
| 12 | GTEx | Cells Transformed fibroblasts | TSPYL4 | 0.13 | 0.16 | lasso | 3 | 0.16 | 1.1e-11 | -5.20 | 5.5 | 4.8e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | FAM26F | 0.29 | 0.19 | enet | 26 | 0.23 | 1.9e-17 | -9.37 | 9.9 | 5.0e-23 | -0.02 | 0.99 | 0.01 | FALSE |
| 14 | GTEx | Cells Transformed fibroblasts | RP1-93H18.7 | 0.08 | 0.06 | enet | 8 | 0.07 | 3.9e-06 | -9.28 | -10.7 | 1.6e-26 | 0.05 | 0.57 | 0.41 | TRUE |
| 15 | GTEx | Esophagus Gastroesophageal Junction | FAM26F | 0.10 | 0.13 | lasso | 2 | 0.06 | 2.3e-03 | 5.33 | 5.6 | 2.7e-08 | 0.05 | 0.23 | 0.10 | FALSE |
| 16 | GTEx | Esophagus Gastroesophageal Junction | RP1-93H18.7 | 0.16 | 0.06 | lasso | 3 | 0.05 | 5.3e-03 | -8.59 | -9.0 | 3.0e-19 | 0.03 | 0.20 | 0.19 | FALSE |
| 17 | GTEx | Esophagus Mucosa | TSPYL4 | 0.20 | 0.20 | enet | 19 | 0.22 | 8.5e-15 | -4.05 | 5.8 | 8.6e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Esophagus Muscularis | RP1-93H18.7 | 0.17 | 0.02 | lasso | 4 | 0.03 | 5.0e-03 | -9.18 | -6.6 | 3.6e-11 | -0.02 | 0.06 | 0.68 | FALSE |
| 19 | GTEx | Lung | RP1-93H18.7 | 0.06 | 0.07 | lasso | 4 | 0.04 | 4.4e-04 | -8.51 | -8.3 | 1.0e-16 | 0.03 | 0.55 | 0.05 | FALSE |
| 20 | GTEx | Muscle Skeletal | TSPYL1 | 0.20 | 0.00 | enet | 47 | 0.02 | 2.9e-03 | -0.38 | -5.2 | 1.9e-07 | 0.05 | 0.44 | 0.06 | FALSE |
| 21 | GTEx | Nerve Tibial | RP1-93H18.7 | 0.14 | 0.08 | lasso | 6 | 0.08 | 1.7e-06 | -8.61 | -8.8 | 1.9e-18 | 0.13 | 0.86 | 0.05 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | RP1-93H18.7 | 0.07 | 0.04 | enet | 5 | 0.03 | 1.1e-03 | -9.33 | -9.1 | 1.2e-19 | 0.03 | 0.43 | 0.10 | FALSE |
| 23 | GTEx | Testis | DSE | 0.36 | 0.41 | lasso | 6 | 0.39 | 1.1e-18 | 5.38 | 5.5 | 3.0e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Testis | FAM26F | 0.23 | 0.10 | lasso | 8 | 0.22 | 3.0e-10 | -9.20 | 10.2 | 1.3e-24 | -0.04 | 0.09 | 0.90 | FALSE |
| 25 | GTEx | Thyroid | GOPC | 0.11 | 0.02 | enet | 23 | 0.02 | 1.6e-02 | 4.04 | -6.8 | 1.1e-11 | 0.18 | 0.50 | 0.03 | TRUE |
| 26 | GTEx | Whole Blood | DSE | 0.09 | 0.05 | lasso | 5 | 0.04 | 1.8e-04 | -9.22 | -8.1 | 5.3e-16 | 0.07 | 0.95 | 0.01 | FALSE |
| 27 | GTEx | Whole Blood | RP1-93H18.7 | 0.19 | 0.17 | lasso | 3 | 0.16 | 3.1e-14 | -8.51 | -9.2 | 5.8e-20 | 0.04 | 1.00 | 0.00 | FALSE |
| 28 | NTR | Blood | DSE | 0.04 | 0.02 | bslmm | 437 | 0.02 | 1.7e-08 | -9.33 | -9.2 | 3.9e-20 | -0.03 | 0.14 | 0.86 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | FAM26F | 0.15 | 0.10 | enet | 13 | 0.13 | 2.6e-16 | 4.55 | 7.4 | 1.2e-13 | -0.01 | 1.00 | 0.00 | TRUE |
| 30 | YFS | Blood | NT5DC1 | 0.07 | 0.03 | bslmm | 431 | 0.04 | 6.4e-13 | 6.25 | -6.0 | 2.0e-09 | 0.04 | 1.00 | 0.00 | TRUE |
| 31 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FAM26F | 0.09 | 0.03 | blup | 48 | 0.06 | 6.0e-06 | 4.14 | 5.6 | 1.8e-08 | -0.05 | 0.43 | 0.03 | FALSE |
| 32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RFX6 | 0.02 | 0.01 | lasso | 3 | 0.01 | 4.2e-03 | -6.65 | -5.9 | 3.8e-09 | 0.26 | 0.10 | 0.07 | TRUE |
| 33 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FAM26F | 0.20 | 0.08 | blup | 48 | 0.10 | 1.3e-05 | 4.92 | 7.1 | 1.6e-12 | 0.00 | 0.16 | 0.57 | FALSE |
| 34 | The Cancer Genome Atlas | Glioblastoma Multiforme | FRK | 0.13 | 0.01 | blup | 94 | 0.05 | 1.5e-02 | -4.73 | -5.6 | 2.7e-08 | -0.04 | 0.03 | 0.22 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FAM26F | 0.40 | 0.20 | lasso | 8 | 0.25 | 2.3e-14 | 6.80 | 7.1 | 1.1e-12 | -0.02 | 0.97 | 0.03 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | DSE | 0.05 | 0.01 | blup | 112 | 0.04 | 1.6e-04 | -0.72 | -6.1 | 1.1e-09 | 0.03 | 0.04 | 0.16 | TRUE |