Best TWAS P=1.37e-12 · Best GWAS P=3.65e-13 conditioned to 0.000111
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | SLC22A3 | 0.13 | 0.06 | enet | 7 | 0.09 | 1.3e-05 | -5.5 | -5.5 | 4.0e-08 | -0.63 | 0.63 | 0.35 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | -6.3 | -6.5 | 9.7e-11 | -0.71 | 0.07 | 0.84 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SLC22A3 | 0.19 | 0.08 | enet | 47 | 0.12 | 1.7e-08 | 5.6 | -7.1 | 1.4e-12 | -0.58 | 0.45 | 0.55 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A3 | 0.15 | 0.05 | lasso | 9 | 0.05 | 9.9e-04 | -3.0 | -5.5 | 4.5e-08 | -0.65 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Testis | SLC22A3 | 0.19 | 0.01 | lasso | 14 | 0.05 | 2.6e-03 | -7.2 | -5.2 | 2.6e-07 | -0.66 | 0.04 | 0.96 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | -5.4 | -5.5 | 3.2e-08 | -0.67 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LPAL2 | 0.07 | 0.00 | blup | 74 | 0.04 | 1.1e-03 | -2.9 | 5.3 | 1.2e-07 | 0.75 | 0.04 | 0.57 | FALSE |