Best TWAS P=2.73e-28 · Best GWAS P=8.98e-33 conditioned to 3.71e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | KLHL7 | 0.18 | 0.10 | lasso | 6 | 0.07 | 7.3e-05 | 1.8 | 5.1 | 2.7e-07 | -0.21 | 0.27 | 0.14 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CCDC126 | 0.12 | 0.03 | lasso | 7 | 0.01 | 4.3e-02 | -8.7 | 8.1 | 7.8e-16 | -0.66 | 0.07 | 0.67 | FALSE |
| 3 | YFS | Blood | CCDC126 | 0.05 | 0.04 | enet | 10 | 0.05 | 1.6e-15 | -6.3 | -5.3 | 1.1e-07 | 0.42 | 1.00 | 0.00 | FALSE |
| 4 | YFS | Blood | TRA2A | 0.07 | 0.04 | lasso | 9 | 0.05 | 3.9e-16 | -9.4 | 5.7 | 1.0e-08 | -0.28 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | TRA2A | 0.18 | 0.02 | blup | 40 | 0.05 | 1.2e-02 | -10.4 | -11.0 | 2.7e-28 | 0.64 | 0.01 | 0.43 | TRUE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS2P32 | 0.08 | 0.02 | blup | 27 | 0.02 | 3.1e-02 | -6.0 | 7.4 | 1.0e-13 | -0.70 | 0.02 | 0.43 | TRUE |