Best TWAS P=1.1e-09 · Best GWAS P=3.11e-10 conditioned to 0.863
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | DENND2A | 0.06 | 0.02 | lasso | 5 | 0.02 | 1.5e-03 | 4.7 | -5.6 | 1.7e-08 | -0.10 | 0.08 | 0.89 | FALSE |
| 2 | The Cancer Genome Atlas | Lung Adenocarcinoma | PARP12 | 0.02 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | 5.9 | -5.9 | 3.3e-09 | -0.88 | 0.01 | 0.90 | FALSE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PARP12 | 0.06 | 0.04 | lasso | 2 | 0.04 | 1.3e-04 | 5.8 | 5.3 | 1.1e-07 | 0.93 | 0.01 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | DENND2A | 0.03 | 0.01 | blup | 71 | 0.01 | 1.3e-02 | 5.1 | 5.9 | 2.8e-09 | 0.12 | 0.02 | 0.86 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | PARP12 | 0.14 | 0.11 | enet | 10 | 0.12 | 9.4e-12 | 6.3 | -6.1 | 1.1e-09 | -0.93 | 0.00 | 1.00 | TRUE |