Hub : Genes

DENND2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0890	0.0280	1.6e-06	0.043	0.050	0.079	0.064	0.075	5.7e-06	8.9e-07	7.0e-10	3.0e-08	1.9e-09
2	GTEx	Esophagus Muscularis	0.2510	0.0640	3.5e-07	0.187	NA	0.100	NA	0.136	1.7e-11	NA	1.2e-06	NA	1.3e-08
3	ROSMAP	Brain Pre-frontal Cortex	0.0595	0.0244	2.1e-03	0.017	0.013	0.011	0.013	0.019	2.8e-03	7.8e-03	1.2e-02	6.7e-03	1.5e-03
4	TCGA	Colon Adenocarcinoma	0.1020	0.0450	9.7e-04	0.020	0.032	0.005	NA	0.009	2.3e-02	5.7e-03	1.6e-01	NA	8.7e-02
5	TCGA	Thyroid Carcinoma	0.0300	0.0150	3.2e-03	0.007	0.014	0.011	NA	0.003	6.3e-02	1.3e-02	2.9e-02	NA	1.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	3.9	6.1	8.1	2.9	0.0	2.8	-2.7	-2.7
Bipolar Disorder or Schizophrenia	4.6	11.2	13.9	3.7	-2.8	3.5	-3.2	-3.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	1.3	0.5	0.4	-0.5	0.2
Depression (Nagel 2018)	0.5	0.8	2.2	1.5	0.5	-0.2	0.4	1.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.3	0.5	0.0	-0.3	0.0	1.1
Neuroticism (Nagel 2018)	0.2	0.6	2.5	1.6	0.5	-0.0	0.0	0.3
Schizophrenia (2018)	2.1	4.3	6.3	2.5	-1.4	2.3	-1.8	-2.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	-0.9	0.0	-1.2	-0.0	0.7
Worry (Nagel 2018)	0.3	0.6	2.3	1.5	0.3	-0.1	0.7	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.3	-0.5	0.1	-0.1	0.3
Alzheimer’s Disease (in father)	1.4	1.5	2.5	0.5	-1.4	1.0	-1.4	-1.6
Alzheimer’s Disease (including proxy)	0.8	1.1	2.5	0.1	-1.6	1.1	-1.0	-1.0
Crohns Disease (2017)	0.3	0.6	1.5	-1.2	0.7	-0.8	-0.4	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-0.5	1.1	-0.8	-0.4	0.1
Ulcerative Colitis (UC)	0.2	0.4	1.4	0.5	1.2	-0.3	-0.2	-0.1
Major Depression (MDD)	1.7	2.1	4.2	2.1	0.0	1.9	-0.9	-1.4
Reaction Time	0.1	0.2	0.5	-0.5	0.1	0.4	0.7	-0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.1	0.2	0.7	-1.0	1.0	2.0
Breast Cancer	0.2	0.4	1.3	-0.6	1.2	-0.6	-0.2	-0.1
Ovarian Cancer	1.4	1.8	5.4	0.0	0.3	1.3	-2.3	-1.4
Prostate Cancer	0.2	0.3	0.7	-0.2	-0.5	-0.1	-0.6	-0.9
Age at First Birth	1.5	2.2	2.7	-1.6	1.3	-1.5	1.5	1.3
Bipolar Disorder (2011)	2.5	2.4	7.8	2.1	0.0	2.8	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.1	-0.4	0.3	-0.3	-0.4
Coronary Artery Disease (CAD)	0.7	0.9	2.3	1.3	0.0	0.5	1.5	-0.5
Crohns Disease (2012)	0.2	0.3	0.7	-0.8	0.3	-0.4	-0.8	-0.2
Mean Putamen Volume	0.7	0.8	2.4	1.0	-0.3	1.6	0.0	-0.5
Fasting Glucose	0.2	0.2	0.8	-0.2	-0.3	0.1	-0.9	-0.5
HbA1C	0.5	0.6	1.7	-0.6	-1.3	-0.4	0.3	0.8
HDL Cholesterol	0.1	0.1	0.2	0.4	0.3	-0.2	0.5	0.1
LDL Cholesterol	1.7	2.6	4.9	0.9	-0.8	1.8	-2.2	-1.9
Lupus	0.3	0.4	1.0	-0.9	-0.3	-1.0	-0.2	-0.2
Neuroticism (2016)	0.3	0.4	0.8	-0.8	0.9	-0.5	-0.2	0.4
Primary Biliary Cirrhosis	0.0	0.1	0.2	-0.1	0.2	-0.1	-0.4	-0.3
Rheumatoid Arthritis	1.3	1.8	2.7	1.0	-1.4	1.5	-1.0	-1.7
Schizophrenia (2014)	1.2	2.7	3.2	1.8	-1.8	1.7	-1.0	-1.8
Triglycerides	0.5	0.8	1.5	1.2	-1.2	0.7	0.7	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	0.3	0.0	1.0	-0.6	-0.7
Ulcerative Colitis	0.3	0.5	0.8	0.9	0.9	0.7	-0.0	-0.5
Blood Eosinophil Count	0.2	1.6	4.9	-1.0	-0.2	0.1	-2.2	-1.4
Blood Platelet Count	0.8	8.7	11.8	1.4	-3.4	3.2	-3.2	-3.0
Blood Red Count	0.1	0.7	1.0	-0.2	0.9	-1.0	0.7	1.0
Blood White Count	0.4	3.1	6.5	1.8	-1.9	2.5	-0.9	-1.2
Heel T-Score	0.5	4.0	8.5	1.4	-1.9	1.4	-2.1	-2.9
BMI	0.1	0.4	1.4	1.2	-0.0	0.6	0.3	0.6
Height	3.0	58.6	76.7	-7.7	7.3	-8.8	6.3	7.9
Waist Hip Ratio (WHR)	1.0	4.3	8.6	-2.9	2.0	-2.4	0.4	1.8
Systolic Blood Pressure	2.7	13.6	17.7	3.7	-4.1	4.2	-2.8	-3.5
Smoking Status	0.1	0.3	0.8	0.9	-0.0	-0.2	0.5	0.4
Allergy or Eczema	0.6	1.6	4.6	2.1	-0.4	1.5	0.1	-1.0
Cardiovascular Disease	2.3	7.5	11.2	3.3	-3.0	3.0	-1.8	-2.4
Hypothyroidism (self reported)	0.2	0.4	0.9	-0.6	0.3	-1.0	0.4	0.7
Respiratory disease	0.3	0.7	1.6	1.0	-0.6	0.2	-1.3	-0.6
Type 2 Diabetes (T2D) (2018)	2.3	4.4	7.9	2.8	-1.9	2.8	-0.6	-1.6
Lung FEV1/FVC ratio	1.4	6.9	14.9	3.9	-2.2	3.2	-1.1	-1.9
Lung FVC	3.5	18.0	24.3	-4.9	4.2	-4.1	4.0	3.9
Neuroticism	0.4	0.9	3.9	2.0	0.3	0.8	0.1	0.1
Chronotype (morning person)	0.3	0.7	1.4	-0.8	0.5	-0.7	1.2	0.8
Hair Pigment	0.0	0.2	0.9	-0.0	-0.9	0.4	-0.3	-0.1
Tanning	0.0	0.5	1.2	-0.4	1.1	-0.6	0.7	0.6
Hand grip strength (left)	5.4	14.3	19.3	-4.1	3.5	-4.4	3.1	3.6
Number of treatments/medications taken	3.8	6.8	7.7	2.8	-2.4	2.6	-2.8	-2.5
Average weekly spirits intake	0.3	0.4	1.3	0.1	0.3	0.2	0.7	1.1
Sensitivity / hurt feelings	0.2	0.4	0.9	0.9	-0.7	0.4	0.3	-0.7
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.0	1.0	1.6	-0.8	1.6	2.0
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.7	-0.6	0.7	-0.0	-0.4
Relative age of first facial hair	1.1	2.3	5.0	-2.2	0.9	-1.6	1.1	1.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	-0.1	0.6	-0.8	1.2	1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	0.8	0.8	-0.0	-0.7	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	-1.0	0.7	-0.7	-0.4	0.5
Systolic blood pressure, automated reading	2.8	8.0	10.8	2.3	-3.3	3.1	-2.2	-3.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.6	1.8	-0.5	1.9	-0.7	-1.1
Angina	0.7	0.9	1.7	-0.6	1.3	-0.8	0.6	1.2
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.2	0.4	-1.1	1.2	0.9
Vitamin and mineral supplements	3.7	5.0	9.4	2.7	-1.5	3.1	-1.8	-1.7
Supplements: Zinc	0.3	0.3	1.1	1.1	-0.4	0.2	0.5	0.3
Medication: Co-codamol	1.0	1.2	4.6	0.3	-0.9	0.3	2.1	0.4
Medication: Metformin	4.0	5.6	8.1	1.6	-2.3	2.5	-2.4	-2.8
Diabetes (father)	0.7	0.8	1.7	-0.2	0.7	-0.5	1.3	1.3
Diabetes (mother)	0.6	0.7	2.6	0.4	-1.6	0.0	-0.6	-0.7
Severe depression (siblings)	0.1	0.2	0.2	-0.5	-0.3	-0.3	-0.5	-0.3
Pack years adult smoking proportion	1.0	1.5	2.6	0.9	-0.8	1.2	-1.6	-1.4
Impedance of leg (right)	0.6	3.0	7.1	0.6	-1.4	1.1	-2.7	-2.2
Leg fat-free mass (left)	1.4	7.6	12.5	-2.1	2.3	-2.6	3.0	3.5
Trunk fat percentage	0.2	0.7	1.9	0.7	-1.4	0.9	-0.7	-0.5
Hand grip strength (right)	2.8	7.7	9.3	-2.7	2.0	-3.1	2.9	3.0
Townsend deprivation index at recruitment	1.4	1.9	2.9	1.1	-1.1	1.7	-1.3	-1.7
Current tobacco smoking	0.5	0.8	1.9	1.4	-0.1	0.9	-0.9	-0.7
Average weekly fortified wine intake	1.9	2.2	4.9	0.5	-0.9	0.9	-2.2	-2.1
Maternal smoking around birth	0.2	0.3	0.7	0.6	-0.2	0.2	0.8	0.3
Fed-up feelings	0.9	1.7	5.0	2.2	-0.8	1.6	-0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.7	1.4	1.7	-0.6	0.5	1.3
Relative age voice broke	1.3	2.0	3.7	-1.9	0.6	-1.1	1.3	1.7
Taking other prescription medications	2.5	3.9	5.0	2.1	-0.9	2.0	-2.2	-2.2
Age when periods started (menarche)	0.2	0.4	0.8	-0.6	0.8	-0.4	0.9	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.6	-0.1	-0.8	0.4	0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.3	-0.0	-1.1	-0.0	-0.5	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	1.0	0.3	0.4	0.3	0.3
Qualifications: CSEs or equivalent	1.3	1.7	2.6	1.6	-1.3	1.4	-0.9	-1.3
Serious illness, injury or assault to yourself	1.2	1.4	3.0	1.7	0.4	-0.2	1.2	1.6
High blood pressure	1.4	4.0	5.4	2.1	-2.2	2.3	-1.4	-1.9
Hayfever, allergic rhinitis or eczema	1.3	2.7	5.6	2.4	-1.3	2.1	-0.1	-1.3
Multivitamins +/- minerals	1.4	1.7	3.8	-1.7	0.6	-1.9	0.7	1.0
Stomach or abdominal pain in last month	1.8	2.2	3.5	1.6	-0.6	1.9	-1.8	-1.3
Supplements: Glucosamine	0.5	0.7	0.9	0.9	-0.9	0.5	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	2.5	0.3	1.6	0.1	0.1	-0.3
Medication: Atenolol	0.8	1.0	1.5	0.9	-0.2	1.2	-1.2	-1.0
Medication: Levothyroxine sodium	0.3	0.6	1.2	-1.1	0.6	-0.9	-0.0	0.7
Sitting height	3.5	25.0	35.3	-4.4	4.5	-5.6	4.3	5.9
Chronic bronchitis/emphysema (father)	3.5	4.1	7.3	1.2	-1.4	1.8	-2.7	-2.5
High blood pressure (mother)	1.4	2.0	2.5	1.3	-1.5	1.5	-1.6	-1.2
Body mass index (BMI)	0.2	0.8	1.3	1.1	-0.8	1.0	-0.8	-0.3
Impedance of leg (left)	0.9	4.3	7.6	1.0	-1.8	1.5	-2.8	-2.7
Leg predicted mass (left)	1.5	8.0	13.1	-2.2	2.3	-2.7	3.1	3.6
Trunk fat mass	0.0	0.2	0.6	-0.2	-0.3	-0.3	0.2	0.7
Waist circumference	0.1	0.5	0.8	-0.9	0.5	-0.8	-0.3	0.8
Number of incorrect matches in round	0.3	0.4	0.6	-0.2	-0.7	0.7	-0.7	-0.8
Past tobacco smoking	2.0	3.6	7.2	1.1	-2.0	1.8	-1.7	-2.7
Alcohol usually taken with meals	0.4	0.6	1.8	0.6	-0.4	-0.3	1.3	0.8
Nervous feelings	0.1	0.3	0.8	0.7	0.9	0.2	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.9	1.3	1.4	-0.8	0.5	0.9
Hearing difficulty/problems with background noise	1.5	2.3	5.1	-0.6	1.1	-1.4	2.3	1.7
Hair/balding pattern: Pattern 2	3.0	3.9	7.4	2.7	-1.6	2.7	-0.8	-1.2
Had menopause	0.8	1.0	2.0	-1.4	1.4	-1.0	0.1	0.3
Had other major operations	1.0	1.2	2.2	-0.2	1.5	-1.2	1.0	1.2
Forced vital capacity (FVC)	5.7	22.0	25.3	-4.7	4.7	-5.0	4.3	4.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.3	-0.5	-1.1	0.0	-0.3	-1.1
Ever unenthusiastic/disinterested for a whole week	4.1	5.0	8.5	2.6	-1.8	2.9	-1.9	-1.7
Qualifications: None of the above	0.8	1.7	3.6	-1.6	1.9	-1.0	0.8	0.6
Financial difficulties in last 2 years	2.3	3.1	4.0	-1.4	1.9	-2.0	1.4	2.0
Mouth/teeth dental problems	0.4	0.6	1.4	0.8	-0.1	0.5	1.2	0.7
Heart attack	1.2	1.6	5.0	0.8	-0.3	0.8	-2.2	-1.3
Allergy	1.6	3.8	8.3	-2.9	1.7	-2.3	0.6	1.5
Pain all over the body in last month	0.4	0.5	0.8	0.4	-0.3	-0.9	0.7	0.9
Diabetes (self-reported)	2.1	3.3	5.1	1.8	-2.0	2.3	-1.3	-1.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.5	-0.9	1.2	-0.6	-0.1	-0.4
Medication: Ramipril	1.5	2.0	3.8	1.2	-1.4	1.9	-0.8	-1.4
Medication: Simvastatin	0.9	1.4	2.2	1.1	-1.2	1.2	-0.7	-1.5
Fluid intelligence score	0.5	1.0	2.1	-0.2	1.0	-1.3	0.2	1.4
Illnesses of siblings	3.3	4.7	5.5	-2.0	2.2	-2.3	2.2	2.0
Neuroticism score	0.4	0.9	3.4	1.9	-0.1	0.9	0.0	0.3
Weight	0.5	2.4	5.2	-1.3	1.1	-1.6	1.3	2.3
Impedance of arm (right)	0.4	2.1	3.6	0.7	-1.5	1.5	-1.3	-1.9
Arm fat percentage (right)	0.2	0.8	1.3	0.8	-0.9	1.0	-1.2	-0.7
Trunk fat-free mass	3.1	17.7	25.5	-3.6	3.8	-4.6	3.8	5.0
Hip circumference	0.0	0.1	0.6	0.1	0.1	0.0	-0.1	0.7
Time employed in main current job	0.0	0.1	0.2	-0.5	-0.1	0.0	0.1	-0.2
Alcohol intake versus 10 years previously	0.6	0.9	2.9	-1.7	0.7	-1.1	-0.3	0.2
Father’s age at death	0.4	0.5	1.3	-0.9	-0.1	-1.1	0.2	0.7
Worrier / anxious feelings	0.1	0.2	0.7	0.2	-0.0	0.2	-0.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.6	1.6	0.6	0.4	0.3	0.7
Falls in the last year	1.4	1.9	2.5	-1.5	1.6	-1.5	0.8	1.5
Hair/balding pattern: Pattern 3	4.4	6.5	10.8	-2.9	3.2	-3.3	0.5	1.7
Number of live births	0.1	0.1	0.6	-0.8	-0.1	-0.2	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1)	2.7	9.2	10.9	-2.5	3.1	-2.9	3.3	3.3
Pulse rate	0.2	0.3	0.9	0.4	-1.0	0.2	-0.2	0.4
Happiness	1.0	1.2	4.4	2.1	-0.2	0.8	0.5	0.7
Noisy workplace	0.2	0.2	0.8	-0.2	0.9	-0.0	0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.6	1.2	-0.5	0.0	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.6	-0.8	0.1	-0.4	0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-0.7	0.2	0.1	-1.4	-1.2
Asthma	0.8	1.5	4.2	2.0	-0.7	1.0	-1.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.2	1.5	-0.3	0.0	0.6	-0.2
Medication: Cholesterol lowering	0.6	1.0	1.6	0.6	-0.9	1.3	-0.8	-1.3
Depression (self-reported)	0.6	0.7	1.5	1.2	-0.0	0.7	-1.1	-0.5
Medication: Lansoprazole	0.8	0.9	2.2	0.5	-0.7	1.1	-1.5	-0.8
Prospective memory result	0.3	0.4	1.1	-0.5	-0.6	1.0	-0.1	-0.6
Lung cancer (father)	1.3	1.5	4.4	1.5	-0.2	0.7	2.1	0.5
Illnesses of mother	1.3	1.6	2.0	-1.4	1.2	-1.4	1.3	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	8.6	-2.5	2.8	-2.9	2.7	2.9
Pulse wave Arterial Stiffness index	1.0	1.2	3.7	-0.5	1.9	-0.8	0.8	0.9
Impedance of arm (left)	0.3	1.2	2.3	0.5	-1.1	1.3	-0.8	-1.5
Arm fat mass (right)	0.0	0.1	0.2	0.0	-0.0	0.0	-0.3	0.4
Trunk predicted mass	3.1	17.6	25.9	-3.5	3.7	-4.6	3.8	5.1
Standing height	2.7	27.0	32.8	-5.2	4.5	-5.7	4.7	5.7
Length of working week for main job	0.9	1.0	2.2	-0.5	1.1	-0.6	1.5	1.0
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.0	0.0	0.4	0.3	-0.3
Breastfed as a baby	1.8	2.2	2.6	-1.5	1.3	-1.5	1.6	1.5
Tense / ‘highly strung’	1.3	2.2	4.4	2.1	-1.8	1.3	-0.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.6	1.9	0.2	1.0	-0.5	-0.3
Hair/balding pattern: Pattern 4	6.2	15.0	31.2	-5.6	3.7	-4.7	1.5	2.4
Birth weight of first child	0.3	0.5	1.6	0.2	0.7	-0.4	0.3	1.3
Peak expiratory flow (PEF)	0.5	1.2	2.4	-0.6	1.2	-1.0	1.0	1.6
Pulse wave reflection index	0.3	0.4	1.8	-0.1	1.4	-0.0	-0.2	-0.3
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.8	1.7	-1.0	1.2	-0.9	-0.9
Loud music exposure frequency	3.5	3.8	4.9	-2.2	1.7	-2.2	1.6	1.9
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	5.9	2.4	-2.3	1.9	-0.9	-1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	-1.3	0.5	-1.4	0.3	0.9
Blood clot in the leg (DVT)	0.3	0.4	0.9	0.3	-0.9	-0.1	1.0	0.5
Medication: Paracetamol	2.9	4.8	7.8	2.4	-2.8	2.2	-1.4	-1.9
Headache pain in last month	1.0	1.7	2.4	1.4	-1.5	1.5	-1.0	-0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	3.1	-1.3	1.6	-1.8	1.4	1.7
Glaucoma (self-reported)	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	-0.1
Gout (self-reported)	0.3	0.4	1.1	0.4	-0.3	0.6	-1.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.7	-1.1	0.7	-1.3	1.0	1.2
Medication: Amlodipine	2.3	3.3	5.0	1.1	-2.2	1.7	-1.9	-2.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	1.9	1.3	-1.0	0.6	-1.4	-1.3
Birth weight	2.5	5.5	11.1	-1.1	3.3	-2.6	1.9	2.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.5	0.7	0.2	-0.1	0.5
High blood pressure (siblings)	7.3	10.6	14.1	2.7	-3.3	3.8	-3.4	-3.0
Forced vital capacity (FVC), Best measure	4.2	15.3	18.7	-4.0	3.8	-4.3	3.4	3.9
Body fat percentage	0.2	1.0	1.9	0.8	-1.4	1.0	-1.0	-0.7
Leg fat percentage (right)	0.5	2.0	4.6	0.8	-1.5	1.1	-2.1	-1.1
Arm fat-free mass (right)	2.3	11.9	18.4	-2.8	3.0	-3.7	3.3	4.3
Exposure to tobacco smoke outside home	1.6	2.2	5.2	-0.5	-1.1	0.3	-2.0	-2.3
Comparative body size at age 10	0.1	0.2	0.5	0.7	0.6	0.4	-0.1	0.1
Number of full brothers	0.3	0.3	0.8	-0.2	0.9	-0.7	0.2	0.6
Worry too long after embarrassment	0.3	0.5	0.9	0.6	1.0	-0.4	0.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.1	-0.1	0.1	-0.6	0.5
Wheeze or whistling in the chest in last year	0.5	0.9	1.7	1.3	-0.0	1.0	-1.3	-0.2
Number of children fathered	0.4	0.5	0.9	0.7	-1.0	-0.0	0.7	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.8	-0.1	-1.1	0.5	0.4
Age at first live birth	0.9	1.6	3.4	-1.3	0.9	-1.9	0.6	1.4
Pulse wave peak to peak time	0.4	0.5	2.3	-0.0	-1.5	0.1	-0.2	-0.2
Health satisfaction	0.4	0.5	1.7	-0.2	0.5	-0.4	0.5	1.3
Shortness of breath walking on level ground	0.8	1.0	2.5	0.7	0.1	-0.4	1.3	1.6
Qualifications: College or University degree	0.2	0.8	2.0	-0.3	0.5	-1.2	0.4	1.4
Eye problems/disorders: None of the above	0.2	0.2	0.8	-0.2	0.9	-0.3	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.7	-1.3	-0.1	-0.7	1.2	0.9
Emphysema/chronic bronchitis	3.8	4.3	6.6	1.2	-2.2	1.8	-2.6	-2.3
Medication for pain relief, constipation, heartburn	2.5	4.3	7.6	-2.8	2.0	-2.4	1.4	1.6
Neck or shoulder pain in last month	1.8	2.6	6.5	2.6	-1.8	1.5	-0.6	-0.7
Medication: Blood pressure	1.7	2.9	3.8	2.0	-1.3	1.9	-1.8	-1.5
Angina (self-reported)	0.6	0.8	1.4	-0.6	1.2	-0.8	0.5	1.1
Migraine (self-reported)	0.9	1.2	1.8	1.2	-1.3	1.3	-0.7	-0.7
Medication: Ibuprofen	0.1	0.1	0.5	0.7	-0.2	-0.0	0.1	-0.4
Medication: Allopurinol	0.0	0.1	0.1	-0.3	-0.2	-0.0	-0.3	0.3
Medication: Omeprazole	0.2	0.3	0.7	0.3	0.8	0.1	0.3	0.5
Medication: Seretide 50 evohaler	0.1	0.2	0.4	0.1	0.2	-0.6	-0.6	-0.1
Mean time to correctly identify matches	0.2	0.4	1.4	-1.2	0.4	0.2	0.8	0.1
Heart disease (mother)	0.5	0.6	1.4	0.7	-0.8	0.5	-0.5	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.0	3.5	7.3	0.9	-1.0	2.2	-2.7	-1.9
Whole body fat mass	0.0	0.1	0.2	-0.1	-0.2	-0.2	-0.1	0.5
Leg fat mass (right)	0.1	0.3	0.9	0.3	-0.5	0.4	-1.0	0.0
Arm predicted mass (right)	2.2	11.4	18.4	-2.7	2.9	-3.6	3.2	4.3
Pulse rate, automated reading	0.3	0.9	3.0	-0.0	-0.7	-0.2	1.1	1.7
Alcohol intake frequency.	1.7	3.9	5.9	2.4	-1.9	2.1	-1.6	-1.7
Comparative height size at age 10	1.5	8.4	11.5	-3.2	2.4	-3.4	2.5	2.9
Number of full sisters	0.5	0.6	1.2	0.6	0.8	-0.6	0.6	1.1
Suffer from ‘nerves’	0.2	0.3	0.7	0.7	0.9	0.1	0.4	0.4
Overall health rating	0.2	0.5	1.3	1.1	0.6	0.7	-0.8	0.1
Chest pain or discomfort	0.4	0.6	2.4	1.6	0.4	0.7	0.1	0.3
Had major operations	0.1	0.1	0.4	-0.1	0.2	-0.0	-0.7	0.1
Age at last live birth	1.6	2.3	4.1	-1.8	1.3	-2.0	0.9	1.3
Family relationship satisfaction	3.4	4.2	8.3	2.9	-1.0	2.6	-1.5	-1.7
Leg pain on walking	0.8	1.0	3.1	-0.3	0.0	-0.2	1.8	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	0.1	0.1	0.0	-0.2	0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.0	-0.9	0.6	-0.9	1.7	1.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.7	0.6	-0.2	1.6	-1.0	-1.6
Medication: Aspirin	0.9	1.1	2.2	0.7	-0.4	1.5	-1.4	-1.0
Supplements: Vitamin C	0.2	0.3	0.5	-0.4	-0.1	-0.7	0.7	-0.3
Knee pain experienced in last month	0.4	0.7	2.2	0.4	-0.1	-0.0	1.5	1.0
Hypertension (Self-reported)	1.2	3.3	4.6	2.1	-1.9	2.1	-1.2	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	0.3	0.6	0.4	-0.9	-0.9
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.7	0.3	-0.1	0.5	-0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.1	-0.1	0.6	0.7	-0.1
Smoking status: Previous	2.5	3.7	7.6	-1.3	1.6	-1.5	2.1	2.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	5.0	-0.8	0.4	-1.4	2.2	2.2
Whole body fat-free mass	2.4	13.7	20.9	-3.0	3.2	-3.9	3.6	4.6
Leg fat-free mass (right)	1.6	8.4	13.0	-2.2	2.4	-2.8	3.3	3.6
Arm fat percentage (left)	0.2	0.7	1.0	0.8	-0.8	1.0	-1.0	-0.6
Average weekly red wine intake	0.1	0.2	0.5	-0.1	-0.3	-0.2	0.7	0.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.6	-1.6	-0.3	-1.1	1.4	0.8
Mood swings	0.2	0.4	1.2	1.1	0.8	0.3	-0.3	0.3
Loneliness, isolation	0.2	0.3	1.1	-0.0	0.1	-0.6	0.1	1.0
Long-standing illness, disability or infirmity	0.5	0.7	2.3	0.8	0.1	0.5	-1.5	-0.7
Ever had bowel cancer screening	0.1	0.2	0.5	0.7	-0.3	0.4	0.1	0.3
Diabetes diagnosed by doctor	2.7	4.5	7.6	2.2	-2.0	2.7	-1.5	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.9	1.4	0.2	0.2	0.7	0.4
Friendships satisfaction	2.8	3.5	5.7	1.5	-2.3	2.4	-0.9	-1.9
Qualifications: nursing, teaching	0.3	0.4	0.9	-0.9	0.3	-0.6	0.8	0.5
Commuting to job workplace: Walk	0.3	0.3	0.7	0.5	-0.2	0.3	-0.9	-0.5
Eye problems/disorders: Cataract	0.6	0.7	1.4	1.2	-0.8	0.8	-0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	0.6	0.6	-0.5	-0.6	-0.3
Medication for cholesterol	0.8	1.2	2.3	-0.8	0.9	-0.7	1.5	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.1	1.8	0.3	1.7	-1.0	-1.6
Back pain experienced in last month	0.3	0.5	0.7	0.7	-0.8	0.6	-0.4	-0.8
Mineral and other dietary supplements	0.6	0.7	1.1	-0.4	-0.8	0.9	-1.0	-1.1
Breast cancer (self-reported)	2.3	2.7	5.3	-1.0	1.4	-1.3	1.9	2.3
Asthma (self-reported)	0.7	1.4	3.7	1.9	-0.6	0.9	-1.2	-0.8
Osteoporosis (self-reported)	2.2	2.8	7.1	-0.4	0.1	-1.3	2.7	2.3
Osteoarthritis (self-reported)	1.3	1.7	2.7	-0.9	1.6	-1.4	0.8	1.6
Medication: Aspirin	1.3	1.7	3.3	1.1	-0.7	1.8	-1.4	-1.1
Medication: Gliclazide	3.2	3.7	6.9	0.5	-1.9	2.2	-1.6	-2.6
Illnesses of father: None of the above (group 1)	0.7	0.9	2.1	0.9	-0.3	-0.1	1.5	1.2
Smoking status: Current	0.4	0.6	1.4	1.2	-0.0	0.7	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	-1.2	0.3	-0.4	0.6	0.1
Whole body water mass	2.4	13.9	21.0	-3.1	3.3	-3.9	3.6	4.6
Leg predicted mass (right)	1.6	8.7	13.1	-2.3	2.5	-2.8	3.3	3.6
Arm fat mass (left)	0.0	0.1	0.5	-0.0	0.2	-0.2	0.1	0.7
Number of self-reported non-cancer illnesses	3.1	5.4	9.5	3.1	-1.9	2.3	-2.0	-2.2
Average weekly champagne plus white wine intake	0.8	1.1	1.6	-0.1	1.0	-1.3	1.1	1.2
Miserableness	1.4	2.5	5.5	2.3	-0.8	2.0	-1.0	-1.0
Guilty feelings	0.3	0.4	1.7	1.3	-0.1	0.5	-0.1	0.4
Wears glasses or contact lenses	0.3	0.3	0.9	0.7	-0.9	-0.0	-0.0	-0.4
Ever taken oral contraceptive pill	0.4	0.5	1.0	-0.5	0.8	-1.0	-0.8	-0.2
Hearing aid user	1.9	2.1	4.6	-0.2	-1.2	0.4	-2.1	-2.1
Mother’s age at death	0.2	0.3	1.1	1.0	0.1	-0.1	0.1	0.4
Financial situation satisfaction	0.8	1.0	1.7	1.1	-0.2	1.3	-1.1	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.6	-0.2	-0.5	0.2	-1.2	-0.3
Commuting to job workplace: Public transport	2.5	2.9	5.7	2.4	-1.4	1.2	-2.0	-1.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.6	-0.7	0.4	0.5	0.0
Medication: Blood pressure	2.7	5.1	6.5	1.8	-2.3	2.4	-2.2	-2.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	1.1	-0.6	0.6	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.3	1.0	-0.7	0.4	0.6
High cholesterol (Self-reported)	1.2	2.2	3.5	1.3	-1.6	1.3	-1.2	-1.9
Medication: Bendroflumethiazide	1.3	2.0	3.4	0.2	-1.6	1.0	-1.8	-1.8
Medication: Paracetamol	1.9	2.9	3.5	1.6	-1.9	1.7	-1.6	-1.6
Medication: Lisinopril	0.7	0.9	2.5	1.6	-1.2	0.5	0.1	-0.0
Medication: Atorvastatin	0.4	0.6	1.7	0.9	-0.4	1.3	-0.3	0.3
Illnesses of father: High blood pressure	0.6	0.8	1.8	-1.4	0.0	-0.8	0.3	1.1
Alcohol drinker status: Never	0.3	0.4	0.6	0.8	-0.8	0.4	-0.3	0.5
Ever smoked	1.3	2.2	4.4	-0.7	2.1	-1.8	0.6	1.7
Basal metabolic rate	1.9	10.7	16.9	-2.7	2.9	-3.5	3.1	4.1
Leg fat percentage (left)	0.6	2.3	4.3	1.0	-1.7	1.3	-2.1	-1.3
Arm fat-free mass (left)	2.2	11.2	17.6	-2.8	2.8	-3.6	3.1	4.2
Number of operations (self-reported)	0.0	0.1	0.1	0.0	0.3	-0.3	-0.4	0.0
Average weekly beer plus cider intake	0.2	0.2	0.4	0.4	-0.5	0.7	-0.2	-0.5
Irritability	0.6	1.0	1.8	1.3	-0.6	0.6	-1.3	-1.0
Risk taking	0.7	1.0	2.8	0.5	-0.8	-0.1	1.7	1.2
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.6	-0.7	1.2	-1.3	2.1	2.0
Fractured/broken bones in last 5 years	0.9	1.2	4.0	0.5	2.0	-0.1	0.0	1.2
Age started oral contraceptive pill	0.9	1.1	2.5	-1.0	1.6	-1.2	0.6	0.3
Diastolic blood pressure, automated reading	4.4	13.7	24.1	3.2	-4.9	3.8	-2.4	-3.7
Ever depressed for a whole week	4.6	5.7	8.9	3.0	-1.7	3.0	-2.2	-1.7
Unable to work because of sickness or disability	0.1	0.1	0.2	0.1	0.4	-0.4	-0.0	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.5	0.4	-1.2	0.7	-0.1	-0.2
Myopia	0.4	0.5	1.1	0.3	-0.5	-0.6	0.9	1.0
Vascular/heart problems diagnosed by doctor	1.5	4.0	4.7	-1.8	2.0	-2.2	2.1	2.0
Cholesterol lowering medication	2.4	3.6	6.6	1.4	-1.6	1.6	-2.6	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.5	1.0	-0.1	0.7	0.8
Pain experienced in last month	1.5	2.5	4.1	-2.0	2.0	-1.6	1.0	0.8
Supplements: Calcium	6.6	7.3	11.6	-1.9	1.9	-3.4	2.7	3.2
Basal cell carcinoma (self-reported)	3.8	4.5	7.9	-2.8	2.4	-2.1	0.6	1.9
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.0	0.9	-0.1	0.6	-2.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.1	-0.7	-0.4	1.1	0.7
Heart disease (siblings)	0.2	0.2	0.8	0.9	-0.3	-0.1	-0.0	0.2
Alcohol drinker status: Previous	1.0	1.1	4.4	2.1	-0.5	0.9	-0.4	-0.4
Pack years of smoking	1.3	1.8	2.8	1.0	-0.9	1.4	-1.7	-1.6
Impedance of whole body	0.5	2.7	4.4	0.9	-1.9	1.5	-1.6	-2.1
Leg fat mass (left)	0.1	0.5	1.1	0.5	-0.7	0.6	-1.1	-0.2
Arm predicted mass (left)	2.2	11.1	17.6	-2.9	2.8	-3.7	2.9	4.2