Hub : Genes

PARP12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1010	0.0420	7.3e-03	0.040	NA	0.023	NA	0.034	2.8e-03	NA	1.8e-02	NA	5.7e-03
2	GTEx	Skin Sun Exposed Lower leg	0.2970	0.0660	6.3e-05	0.009	NA	-0.003	NA	0.001	5.3e-02	NA	9.3e-01	NA	2.6e-01
3	GTEx	Testis	0.2120	0.0820	8.1e-03	0.068	NA	0.032	NA	0.051	6.1e-04	NA	1.4e-02	NA	2.7e-03
4	TCGA	Brain Lower Grade Glioma	0.0450	0.0244	4.7e-03	0.004	0.015	0.016	NA	0.008	9.7e-02	6.1e-03	5.6e-03	NA	3.8e-02
5	TCGA	Lung Adenocarcinoma	0.0239	0.0128	7.2e-03	0.012	0.010	0.001	NA	0.006	1.4e-02	2.4e-02	2.2e-01	NA	6.0e-02
6	TCGA	Prostate Adenocarcinoma	0.0593	0.0284	1.3e-03	0.044	0.026	0.029	NA	0.035	1.9e-05	8.7e-04	4.4e-04	NA	1.3e-04
7	TCGA	Thyroid Carcinoma	0.1360	0.0440	5.2e-10	0.108	0.120	0.120	NA	0.114	1.3e-10	1.1e-11	9.4e-12	NA	3.5e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	0.9	1.7	-0.3	0.7	-1.0	-0.9	-1.1	0.8	-1.3
Bipolar Disorder or Schizophrenia	0.6	1.5	3.1	0.4	-1.2	-1.3	-1.0	-1.2	1.3	-1.8
Depressed Affect (Nagel 2018)	1.0	2.0	5.7	-1.7	-1.1	2.4	-0.5	1.7	-0.8	0.7
Depression (Nagel 2018)	2.9	4.4	10.1	0.4	-2.0	3.2	2.4	2.7	-1.3	1.4
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.0	-0.1	-1.7	-0.9	-0.6	-1.3	1.5	-1.2
Neuroticism (Nagel 2018)	0.8	1.9	6.8	-0.8	-1.6	2.6	-0.0	1.7	-0.5	0.1
Schizophrenia (2018)	0.5	1.1	3.1	0.8	-1.8	-0.9	-0.5	-0.6	1.0	-1.2
Schizophrenia vs Biploar Disorder	0.8	1.1	3.4	-0.5	0.1	-0.9	-0.4	-1.7	0.0	-1.8
Worry (Nagel 2018)	0.3	0.6	2.7	-0.2	-1.6	0.7	0.2	0.6	-0.3	-0.3
Alzheimer’s Disease (in mother)	0.6	0.7	3.3	-0.3	0.6	0.2	1.8	0.3	-0.2	0.8
Alzheimer’s Disease (in father)	1.8	2.0	3.9	-1.8	0.4	-0.9	-1.1	-1.5	2.0	-1.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.2	0.4	-1.0	0.7	-0.8	0.9	-0.1
Crohns Disease (2017)	0.5	1.1	4.1	-0.4	-0.1	2.0	0.5	1.5	-0.2	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	2.9	-0.9	0.2	1.7	0.0	1.2	-0.8	0.7
Ulcerative Colitis (UC)	0.3	0.5	1.3	-1.1	0.1	1.1	-0.1	0.5	-1.0	0.2
Major Depression (MDD)	0.5	0.6	0.9	-0.7	-0.5	0.8	-0.5	0.8	-0.9	0.9
Reaction Time	0.2	0.4	0.8	-0.9	0.1	0.8	-0.6	0.8	-0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.1	0.3	-1.5	-0.9	0.5	-0.9	1.2	-0.5
Breast Cancer	0.4	1.0	6.3	-0.4	0.2	0.4	-2.5	0.0	0.3	0.2
Ovarian Cancer	0.6	0.8	2.0	-1.4	0.6	-0.1	-1.1	-1.0	0.9	-0.5
Prostate Cancer	0.5	0.7	1.2	0.7	0.8	-1.1	-0.4	-1.1	0.5	-1.0
Age at First Birth	1.5	2.2	4.3	-0.3	1.9	-1.4	-2.1	-1.6	1.3	-1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	0.5	-0.2	-1.0	1.5	-0.1	0.0	-0.0
Coronary Artery Disease (CAD)	1.0	1.2	3.2	0.8	0.8	0.7	0.8	1.7	0.0	1.8
Crohns Disease (2012)	1.0	1.7	3.6	-1.9	0.7	1.9	-0.5	1.4	0.0	1.4
Mean Putamen Volume	4.4	5.0	11.4	0.7	-0.7	-2.1	-2.2	-2.8	2.4	-3.4
Fasting Glucose	2.6	3.1	9.0	1.3	0.6	-1.6	-0.7	-1.7	2.2	-3.0
HbA1C	3.3	3.7	7.9	1.6	-0.8	-0.4	2.8	1.7	-2.6	2.2
HDL Cholesterol	1.1	1.9	5.0	-2.2	-0.4	0.0	-1.7	-1.3	1.0	-1.6
LDL Cholesterol	0.6	1.0	3.2	-0.0	0.3	-0.2	1.8	0.6	-1.1	1.5
Lupus	0.9	1.4	2.8	-1.4	1.7	-0.9	-0.5	-1.1	1.1	-1.1
Neuroticism (2016)	0.3	0.4	1.4	1.2	0.1	0.4	-0.7	-0.1	-0.5	-0.8
Primary Biliary Cirrhosis	1.3	1.9	4.9	0.8	-0.2	-2.2	-0.2	-1.9	1.1	-1.8
Rheumatoid Arthritis	1.1	1.5	2.9	-1.0	1.7	-0.7	-0.6	-1.3	1.0	-1.7
Schizophrenia (2014)	0.5	1.1	2.5	-0.1	-0.7	-1.3	-0.6	-1.1	1.1	-1.6
Triglycerides	1.5	2.5	5.3	0.7	0.6	2.3	1.6	2.3	-1.4	1.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.7	0.0	-0.1	-0.7	-0.3	0.0	-0.3
Ulcerative Colitis	1.0	1.5	3.8	-0.4	0.0	1.4	0.9	2.0	0.0	1.9
Blood Eosinophil Count	2.3	18.0	33.3	0.9	-1.3	4.2	3.7	5.2	-5.8	5.7
Blood Platelet Count	1.9	21.7	41.2	2.5	1.1	4.1	3.4	6.1	-6.4	6.2
Blood Red Count	0.7	6.8	10.8	2.3	-2.5	2.0	2.3	3.3	-2.8	2.8
Blood White Count	2.3	16.8	31.9	1.9	-1.3	3.2	3.2	5.5	-5.7	5.5
Heel T-Score	0.2	1.8	4.9	-0.3	0.9	0.1	1.6	1.3	-1.6	2.2
BMI	0.2	1.0	2.7	1.2	-1.2	-1.6	0.1	-0.7	0.2	-1.1
Height	3.6	69.5	102.0	-8.4	0.9	-6.5	-9.7	-10.1	8.9	-9.9
Waist Hip Ratio (WHR)	1.2	5.5	13.8	-1.6	-1.2	2.1	-0.3	2.5	-3.7	3.2
Systolic Blood Pressure	0.3	1.4	3.9	0.8	-0.5	0.9	1.0	1.3	-1.1	2.0
Smoking Status	0.3	0.7	2.4	0.4	0.4	0.1	0.6	0.8	-1.6	1.1
Allergy or Eczema	0.2	0.6	1.1	-1.0	0.4	-0.9	0.4	-1.0	0.8	-0.6
Cardiovascular Disease	0.4	1.5	3.8	0.6	-1.4	1.6	0.5	1.9	-0.6	1.0
Hypothyroidism (self reported)	0.3	0.7	1.6	0.4	-0.3	1.3	1.2	1.1	-0.6	0.2
Respiratory disease	0.1	0.2	1.2	-1.1	0.1	0.0	-0.3	-0.4	-0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-0.3	0.2	0.8	-0.4	1.1	-1.2	0.9
Lung FEV1/FVC ratio	2.1	10.7	21.2	4.6	-0.1	2.0	2.2	4.2	-3.5	3.9
Lung FVC	1.2	6.3	15.2	3.0	0.9	-3.9	0.3	-3.1	1.9	-2.3
Neuroticism	0.9	2.2	6.8	-0.1	-0.8	2.6	1.0	2.3	-1.1	0.9
Chronotype (morning person)	1.2	2.7	4.8	-1.8	-1.3	2.1	-0.4	1.6	-1.5	2.2
Hair Pigment	0.1	3.0	5.5	1.4	0.8	-2.2	1.9	0.5	-2.1	2.4
Tanning	0.0	0.4	1.5	-0.1	1.1	0.3	-1.2	0.2	-0.5	0.0
Hand grip strength (left)	0.6	1.7	4.3	0.0	1.0	-1.7	-0.7	-2.1	1.5	-1.0
Number of treatments/medications taken	0.1	0.2	0.9	-0.5	0.0	0.4	0.9	0.6	-0.2	-0.3
Average weekly spirits intake	0.4	0.5	1.4	-0.4	0.4	-1.2	-1.0	-0.8	-0.2	-0.0
Sensitivity / hurt feelings	1.2	2.1	6.0	0.6	-1.0	2.5	1.9	1.9	-0.5	-0.2
Frequency of depressed mood in last 2 weeks	1.9	2.6	8.0	0.1	-1.7	2.8	0.7	2.1	-0.8	1.5
Hearing difficulty/problems: Yes	2.4	3.6	8.5	-1.3	-0.2	-2.9	-0.9	-2.7	1.7	-2.0
Relative age of first facial hair	0.7	1.4	5.9	2.4	-0.0	-0.5	0.0	-0.8	1.4	-0.9
Other serious medical condition/disability diagnosed by doctor	1.7	2.1	4.3	-1.3	-1.9	-0.1	-2.1	-1.2	0.9	-1.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.9	-0.3	-0.7	0.5	-0.5	-0.6	-0.8
Ever had hysterectomy (womb removed)	1.5	1.7	4.6	1.7	-1.8	0.4	2.1	0.7	-0.5	0.8
Systolic blood pressure, automated reading	0.3	0.8	2.1	0.8	-0.0	-1.4	0.4	-1.2	0.9	-0.7
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.5	-1.3	0.9	1.1	0.3	1.4	-1.4	1.6
Angina	3.8	5.1	9.0	-2.3	-0.7	1.8	1.5	2.9	-3.0	2.6
Medication for hormone replacement therapy	1.9	2.1	6.2	-0.2	0.4	1.0	1.0	1.9	-2.5	1.7
Vitamin and mineral supplements	0.3	0.5	1.0	-0.3	0.7	0.7	-0.3	0.6	-0.9	1.0
Supplements: Zinc	0.3	0.3	0.8	0.5	-0.2	0.6	0.7	0.3	-0.3	0.9
Medication: Co-codamol	0.4	0.4	1.1	-0.4	-1.0	-0.6	0.0	0.4	-1.1	0.6
Medication: Metformin	0.7	1.0	3.3	-1.8	0.7	0.4	-1.2	0.5	-1.1	0.7
Diabetes (father)	1.2	1.5	6.5	-2.5	1.7	0.5	-1.0	0.0	-0.0	-0.4
Diabetes (mother)	0.2	0.3	0.7	0.8	0.0	0.7	0.2	0.1	0.3	-0.8
Severe depression (siblings)	0.3	0.3	0.9	-0.4	0.9	-0.4	0.7	0.1	-0.9	0.1
Pack years adult smoking proportion	3.1	4.8	12.7	-0.7	-0.9	2.3	0.4	2.6	-3.6	2.7
Impedance of leg (right)	3.3	16.1	32.4	-0.5	0.9	5.2	2.5	5.7	-4.4	5.1
Leg fat-free mass (left)	4.0	21.3	37.3	-2.6	0.3	-4.7	-4.5	-6.1	5.3	-5.8
Trunk fat percentage	0.0	0.1	0.6	0.0	-0.1	0.2	0.0	0.6	-0.8	-0.0
Hand grip strength (right)	0.2	0.7	1.2	-1.0	0.4	-0.7	-1.0	-1.1	0.7	-0.5
Townsend deprivation index at recruitment	0.4	0.6	3.3	1.8	0.6	-0.8	0.3	-0.2	-0.0	-0.1
Current tobacco smoking	0.5	0.9	2.5	-0.8	-0.5	0.8	0.2	1.0	-1.6	1.1
Average weekly fortified wine intake	0.2	0.2	0.7	-0.7	-0.1	0.8	0.1	0.1	0.4	0.0
Maternal smoking around birth	0.6	0.8	2.1	1.4	-1.3	0.3	0.7	0.9	-0.3	0.8
Fed-up feelings	1.1	2.0	8.0	-0.2	-0.1	2.8	-0.2	2.1	-0.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	4.5	6.0	10.8	1.1	-2.0	3.2	2.3	3.3	-2.1	2.5
Relative age voice broke	0.3	0.5	1.1	0.9	-0.4	-1.0	-0.4	-0.8	0.7	-0.5
Taking other prescription medications	0.4	0.7	1.9	-1.4	0.6	0.8	0.1	0.9	-0.9	0.5
Age when periods started (menarche)	1.1	2.7	6.3	-0.4	0.6	-2.5	-0.8	-2.4	1.5	-1.8
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	4.0	-2.0	-1.6	0.0	-0.3	-0.1	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.2	0.3	-0.0	-0.6	0.6	-0.7	0.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.0	0.6	-1.6	1.7	-0.4	0.9	0.4	-0.0
Qualifications: CSEs or equivalent	0.3	0.4	2.3	0.1	1.5	0.2	-0.1	0.1	0.2	-0.4
Serious illness, injury or assault to yourself	1.3	1.5	3.0	-0.2	-1.6	1.2	0.7	1.6	-1.7	0.8
High blood pressure	0.1	0.2	1.4	0.1	-1.2	0.3	-0.0	0.1	0.2	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	0.3	0.7	-0.3	1.0	-0.5	0.9	-0.4
Multivitamins +/- minerals	0.7	0.9	2.3	0.8	-0.2	-0.7	0.0	-0.9	1.5	-1.5
Stomach or abdominal pain in last month	0.6	0.7	4.3	2.1	-0.5	-0.4	0.6	-0.0	0.2	-0.1
Supplements: Glucosamine	4.6	6.0	13.3	0.3	0.3	-2.5	-0.5	-3.1	3.6	-3.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	0.7	0.5	-1.1	1.1	-1.1	0.9	-0.1
Medication: Atenolol	0.4	0.5	1.9	0.2	1.4	0.4	0.5	0.7	-0.5	0.4
Medication: Levothyroxine sodium	0.4	0.6	1.9	0.0	-0.5	1.3	1.4	0.7	0.2	0.0
Sitting height	3.2	22.4	37.1	-4.0	0.4	-3.9	-5.0	-5.9	5.3	-6.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	-1.2	-0.7	0.5	0.2	0.8	-0.3	0.5
High blood pressure (mother)	0.9	1.3	3.0	1.7	-1.5	1.1	-0.2	0.4	1.3	-0.9
Body mass index (BMI)	0.2	0.8	3.2	1.8	-0.7	-1.0	0.2	-0.1	-0.2	-0.8
Impedance of leg (left)	3.2	15.4	30.2	-0.2	1.0	4.9	2.5	5.5	-4.5	5.1
Leg predicted mass (left)	4.0	21.2	37.1	-2.6	0.2	-4.7	-4.4	-6.1	5.3	-5.9
Trunk fat mass	0.2	0.9	2.4	-0.6	0.1	-1.0	-1.1	-1.0	0.6	-1.6
Waist circumference	0.2	0.8	1.9	-0.6	-0.4	-1.3	-0.8	-1.0	0.2	-1.4
Number of incorrect matches in round	1.1	1.8	4.6	-0.4	2.1	-1.8	-0.9	-1.3	0.6	-1.4
Past tobacco smoking	0.5	0.9	2.7	0.1	-0.6	1.6	-1.2	1.2	-0.4	0.2
Alcohol usually taken with meals	0.7	1.2	4.2	-2.0	-0.7	1.1	-0.6	1.0	-0.9	0.6
Nervous feelings	0.1	0.2	0.5	-0.5	-0.7	0.7	-0.4	0.3	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	4.9	1.0	-0.6	2.2	1.4	2.1	-1.0	1.2
Hearing difficulty/problems with background noise	4.8	7.7	12.7	-2.2	-1.8	-2.7	-2.5	-3.2	3.0	-3.6
Hair/balding pattern: Pattern 2	0.5	0.6	2.6	0.4	-0.2	1.6	-0.8	0.7	-0.5	0.4
Had menopause	0.6	0.8	4.1	-1.1	-2.0	0.2	0.1	0.0	-0.0	-0.6
Had other major operations	0.3	0.3	0.9	-0.8	-0.2	0.5	0.0	0.3	0.5	-1.0
Forced vital capacity (FVC)	2.6	10.0	19.3	-0.3	2.1	-4.4	-2.3	-4.2	3.2	-3.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.4	-0.4	0.2	0.4	-0.2	0.9	-1.2	1.0
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	7.8	1.5	-0.3	2.5	1.9	2.8	-1.6	2.7
Qualifications: None of the above	0.3	0.6	1.6	-0.8	-0.4	-1.1	-1.2	-0.5	-0.2	-0.5
Financial difficulties in last 2 years	1.6	2.2	7.2	2.7	-0.1	1.6	1.6	1.5	-0.4	0.9
Mouth/teeth dental problems	0.2	0.3	0.6	0.3	0.7	0.5	0.2	0.6	-0.7	0.5
Heart attack	2.9	3.7	6.1	-1.5	-0.1	2.0	1.9	2.5	-2.3	2.2
Allergy	0.3	0.6	2.6	0.5	-0.9	-0.4	-1.6	-0.2	0.2	-0.7
Pain all over the body in last month	0.8	0.8	2.6	1.3	1.6	0.6	0.7	0.5	-0.5	0.2
Diabetes (self-reported)	0.8	1.2	2.3	-1.1	0.4	0.7	0.4	1.4	-1.5	1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.5	-1.2	0.1	-0.7	-0.7	-1.0	0.5	-0.5
Medication: Ramipril	0.5	0.6	2.1	-1.5	-1.3	0.0	-0.4	-0.2	0.0	-0.5
Medication: Simvastatin	0.7	1.0	2.2	-1.5	-0.8	1.0	-0.8	0.9	-1.2	0.5
Fluid intelligence score	0.8	1.7	8.2	-0.4	-2.9	-0.6	-0.4	-0.9	1.4	-0.3
Illnesses of siblings	0.5	0.7	3.7	-0.0	1.9	0.3	0.6	-0.1	0.2	0.9
Neuroticism score	1.6	3.3	10.0	0.5	-0.7	3.2	0.9	2.7	-1.2	1.6
Weight	1.4	7.0	13.5	-1.3	0.1	-2.9	-2.8	-3.4	2.5	-3.7
Impedance of arm (right)	1.9	8.9	15.9	-1.7	0.6	3.9	0.9	3.8	-3.5	4.0
Arm fat percentage (right)	0.2	0.9	2.2	1.5	-0.0	0.2	0.8	1.2	-1.4	0.6
Trunk fat-free mass	4.8	27.6	48.9	-3.0	0.6	-5.1	-4.9	-6.8	6.2	-7.0
Hip circumference	0.9	4.1	10.8	-0.7	0.0	-2.0	-1.5	-2.4	2.3	-3.3
Time employed in main current job	0.4	0.5	1.8	0.1	0.6	-1.3	0.2	-0.8	0.0	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.9	-0.8	0.5	0.0	-0.0	0.3	0.3
Father’s age at death	1.2	1.6	3.8	0.6	1.8	-1.1	0.1	-1.2	1.1	-1.9
Worrier / anxious feelings	0.2	0.5	1.2	0.7	-1.1	0.8	0.2	0.1	0.8	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.6	1.0	-0.1	0.9	1.9	1.1	-0.7	0.5
Falls in the last year	0.9	1.2	2.3	0.5	0.1	-1.3	0.7	-1.3	1.5	-1.3
Hair/balding pattern: Pattern 3	0.6	0.8	3.2	-0.2	1.8	-0.8	0.9	-0.0	-1.0	0.3
Number of live births	0.5	0.7	1.6	-0.9	1.1	-0.8	0.1	-0.5	0.5	-1.3
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	12.9	1.3	1.8	-3.6	-1.6	-2.9	2.2	-2.3
Pulse rate	0.5	0.9	5.3	2.3	-0.3	-0.4	0.3	0.2	-0.3	-0.4
Happiness	0.2	0.2	0.5	-0.3	-0.6	0.5	0.1	-0.1	0.7	-0.6
Noisy workplace	0.6	0.8	3.7	0.7	1.9	0.8	0.0	0.6	-0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.1	0.1	-1.1	-1.0	-0.2	-0.4	-0.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	-1.0	-1.5	-0.4	-0.7	-0.9	0.9	-0.8
Mouth/teeth dental problems: Dentures	1.0	1.6	4.2	-0.3	-0.1	0.8	1.0	1.6	-2.0	1.6
Asthma	0.2	0.3	1.3	-0.2	-0.1	-0.1	0.7	-0.0	-0.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.8	1.5	-0.8	0.4	1.7	0.6	0.5	-0.5
Medication: Cholesterol lowering	0.6	0.9	2.8	-1.7	-1.1	0.2	-0.3	0.8	-1.0	0.8
Depression (self-reported)	1.0	1.2	2.6	-0.8	0.5	1.6	1.6	1.3	-0.8	0.8
Medication: Lansoprazole	0.5	0.6	1.5	0.3	1.2	-0.3	0.7	0.2	-1.0	1.0
Prospective memory result	1.2	1.4	3.2	0.9	1.0	0.6	1.6	1.2	-1.8	0.8
Lung cancer (father)	0.9	1.1	5.2	0.7	2.3	-1.0	0.7	-0.5	0.5	-0.2
Illnesses of mother	0.1	0.2	0.5	-0.3	0.5	-0.1	-0.7	-0.6	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	11.2	1.6	2.0	-3.3	-1.5	-2.5	1.6	-2.2
Pulse wave Arterial Stiffness index	1.3	1.5	3.7	0.2	1.9	0.9	0.3	1.1	-1.6	1.3
Impedance of arm (left)	1.4	6.7	12.7	-1.9	1.0	3.3	0.5	3.1	-3.0	3.6
Arm fat mass (right)	0.2	0.9	2.3	0.7	-0.3	-1.4	-0.7	-0.9	0.4	-1.5
Trunk predicted mass	4.8	27.6	49.1	-3.0	0.7	-5.2	-4.9	-6.7	6.2	-7.0
Standing height	3.7	36.4	54.0	-6.7	1.8	-4.7	-6.9	-7.3	6.2	-6.7
Length of working week for main job	2.1	2.4	9.6	2.1	-0.8	-0.2	3.1	0.7	-0.8	1.0
Exposure to tobacco smoke at home	0.6	0.7	2.0	-1.2	-0.8	1.4	0.0	0.8	-0.5	-0.2
Breastfed as a baby	0.2	0.3	1.3	0.2	1.1	-0.3	0.2	-0.3	-0.4	-0.5
Tense / ‘highly strung’	1.5	2.5	5.2	0.5	-0.5	1.7	0.6	2.3	-2.0	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	4.6	7.1	13.4	0.7	-0.1	3.5	2.3	3.7	-2.9	3.1
Hair/balding pattern: Pattern 4	0.4	0.9	2.9	-1.6	-1.7	-0.6	0.1	-0.0	-0.4	0.7
Birth weight of first child	1.3	2.3	4.2	-0.2	-1.4	-1.2	-0.7	-2.0	2.0	-2.0
Peak expiratory flow (PEF)	0.7	1.7	5.2	2.0	0.8	-2.3	-0.5	-1.1	0.6	-0.6
Pulse wave reflection index	2.6	3.3	5.6	0.7	1.8	1.9	1.1	2.4	-2.2	2.0
Ever highly irritable/argumentative for 2 days	2.1	2.6	6.1	1.4	2.5	1.5	-0.1	1.6	-1.7	1.5
Loud music exposure frequency	4.1	4.5	8.4	0.4	-0.9	1.2	2.6	2.3	-2.9	2.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	-1.1	-0.2	-0.3	0.3	0.0	-0.4	0.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.6	0.8	-1.1	-1.1	-0.0	-1.7	2.1	-1.6
Blood clot in the leg (DVT)	1.1	1.4	5.5	-0.5	1.1	1.0	2.4	1.3	-0.4	0.4
Medication: Paracetamol	0.5	0.8	3.3	1.8	-0.2	-0.6	1.0	-0.5	0.5	-0.8
Headache pain in last month	0.5	0.8	1.9	0.3	1.2	-0.8	0.8	-1.0	1.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.0	0.4	1.3	-1.2	-0.2	-1.4	1.2	-1.1
Glaucoma (self-reported)	1.3	1.5	6.7	2.6	0.9	-0.9	1.4	-0.3	-0.1	-0.4
Gout (self-reported)	0.2	0.2	0.8	-0.5	0.2	0.5	-0.1	0.9	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.4	0.9	-0.2	2.1	1.5	2.0	-1.1	0.8
Medication: Amlodipine	0.5	0.6	1.7	-1.3	0.8	0.7	0.6	0.6	-0.8	0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.4	-0.3	0.1	-1.8	-0.8	-1.3	0.2	-0.4
Birth weight	1.2	2.5	5.2	-1.1	0.2	-0.8	-1.5	-1.9	2.1	-2.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.1	-1.5	-0.4	-0.5	-1.2	-0.7	0.5	-0.4
High blood pressure (siblings)	0.4	0.6	2.8	0.7	-1.7	-0.6	0.2	0.3	-0.5	-0.1
Forced vital capacity (FVC), Best measure	3.0	11.1	19.8	-0.1	2.0	-4.4	-2.8	-4.4	3.1	-4.1
Body fat percentage	0.2	0.7	1.9	0.8	0.1	0.4	0.7	1.3	-1.4	0.6
Leg fat percentage (right)	0.7	2.7	6.1	1.7	0.1	1.3	1.6	2.5	-1.9	1.4
Arm fat-free mass (right)	4.0	20.7	37.3	-2.2	0.5	-4.6	-4.0	-6.0	5.5	-6.1
Exposure to tobacco smoke outside home	0.3	0.5	1.7	-0.6	-1.3	0.8	0.3	0.2	0.2	-0.6
Comparative body size at age 10	0.1	0.2	0.4	-0.4	0.2	0.6	-0.5	0.5	-0.5	0.1
Number of full brothers	1.2	1.6	2.4	-1.3	1.3	-1.2	-1.2	-1.6	1.0	-1.1
Worry too long after embarrassment	1.4	2.4	10.8	1.1	-0.5	3.3	0.0	2.0	0.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	7.2	0.3	1.1	2.7	0.8	1.9	-0.0	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	0.4	-0.5	-0.1	-1.0	-0.7	-0.0	-0.5
Number of children fathered	0.7	0.8	4.0	1.1	0.1	-2.0	0.4	-0.5	-0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	-0.4	0.3	0.8	-0.7	0.2	0.9	0.1
Age at first live birth	0.4	0.7	2.0	-1.1	0.3	-0.4	-1.4	-0.8	0.9	-0.3
Pulse wave peak to peak time	2.0	2.4	4.2	-0.8	-1.9	-1.3	-0.7	-1.6	2.1	-1.8
Health satisfaction	0.1	0.1	0.3	-0.4	0.5	0.1	-0.5	0.1	0.1	-0.5
Shortness of breath walking on level ground	1.2	1.5	3.7	0.4	1.9	1.2	0.6	1.3	-1.2	1.2
Qualifications: College or University degree	0.6	2.0	4.1	-1.6	-1.2	-0.6	-0.8	-1.5	1.6	-2.0
Eye problems/disorders: None of the above	0.4	0.4	1.0	-0.9	0.3	0.5	-0.6	-0.4	1.0	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.4	0.4	-0.2	-0.7	-0.5	0.6	-0.6
Emphysema/chronic bronchitis	0.7	0.8	2.9	-0.2	1.2	1.7	-0.3	0.4	-0.2	0.8
Medication for pain relief, constipation, heartburn	0.8	1.4	4.8	-1.8	0.1	-0.3	-2.2	-1.3	0.4	0.1
Neck or shoulder pain in last month	1.2	1.7	3.5	1.0	-0.1	-1.0	-0.5	-1.8	1.9	-1.8
Medication: Blood pressure	0.2	0.3	1.2	-0.3	-0.9	1.1	0.1	0.5	0.1	0.3
Angina (self-reported)	3.0	4.0	6.2	-2.4	-0.8	1.4	1.2	2.5	-2.5	2.3
Migraine (self-reported)	5.9	7.3	15.6	0.8	-1.1	-2.3	-2.0	-3.6	3.3	-4.0
Medication: Ibuprofen	1.1	1.3	3.3	1.5	-1.2	0.9	1.8	1.1	-0.1	0.4
Medication: Allopurinol	0.9	1.2	3.7	-1.1	0.2	1.9	-0.2	1.6	-0.7	0.4
Medication: Omeprazole	0.5	0.6	1.2	-0.1	-1.1	-1.1	-0.9	-0.7	0.1	-0.6
Medication: Seretide 50 evohaler	1.7	2.0	3.2	-1.1	1.2	1.8	0.8	1.7	-1.4	1.5
Mean time to correctly identify matches	0.1	0.3	0.8	-0.3	-0.1	-0.0	-0.6	0.1	0.7	-0.9
Heart disease (mother)	1.3	1.6	2.8	-1.3	-0.5	1.6	0.8	1.7	-1.0	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.8	1.4	-0.4	1.6	0.5	1.7	-0.9	1.1
Whole body fat mass	0.2	0.6	2.0	0.1	0.2	-1.1	-0.8	-0.7	0.4	-1.4
Leg fat mass (right)	0.1	0.3	1.0	0.5	0.2	-0.9	-0.3	-0.3	0.1	-1.0
Arm predicted mass (right)	3.9	19.8	36.2	-2.4	0.3	-4.5	-3.7	-5.8	5.3	-6.0
Pulse rate, automated reading	0.6	2.0	4.3	2.1	-2.1	0.6	0.9	1.2	-1.2	1.0
Alcohol intake frequency.	0.3	0.6	3.0	0.5	-1.7	-0.0	-0.6	0.6	-0.4	-0.2
Comparative height size at age 10	3.1	17.2	24.9	-5.0	1.4	-3.0	-4.9	-4.8	4.2	-4.3
Number of full sisters	0.4	0.5	1.4	1.2	-0.3	-0.6	-1.0	-0.2	0.2	-0.7
Suffer from ‘nerves’	0.3	0.4	2.4	-0.0	-1.6	0.1	-0.0	0.1	0.0	-0.6
Overall health rating	0.3	0.6	1.1	1.0	-0.4	-1.0	-0.3	-1.0	0.4	-0.9
Chest pain or discomfort	0.7	0.9	3.2	1.7	-1.8	0.4	-0.2	0.5	-0.2	-0.3
Had major operations	0.1	0.2	0.6	-0.2	0.4	0.1	-0.3	0.2	-0.5	0.8
Age at last live birth	1.1	1.6	2.9	-0.8	1.5	-1.7	-0.9	-1.7	1.2	-0.7
Family relationship satisfaction	0.2	0.2	0.6	0.7	-0.3	-0.3	0.8	0.2	0.1	0.2
Leg pain on walking	0.3	0.3	1.6	-0.0	-1.2	0.4	0.7	0.1	-0.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	6.0	7.2	13.3	0.7	-0.5	2.5	2.6	3.4	-3.5	3.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.9	1.0	0.2	-0.5	-0.0	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	6.2	-1.4	2.5	0.0	-0.7	-0.6	0.1	0.0
Medication: Aspirin	1.1	1.4	3.5	-1.4	-0.6	0.8	0.3	1.5	-1.9	0.9
Supplements: Vitamin C	0.3	0.3	1.7	-1.3	-0.3	-0.7	0.1	-0.4	-0.1	0.1
Knee pain experienced in last month	0.9	1.5	4.4	-0.1	0.7	-2.1	1.0	-1.4	1.3	-0.8
Hypertension (Self-reported)	0.2	0.4	2.1	0.1	-1.5	0.8	0.0	0.5	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	1.1	-0.0	-0.3	1.3	0.2	-1.2	0.8
Illnesses of father: Heart disease	2.0	2.8	6.4	-0.4	-1.1	2.2	0.6	2.5	-1.5	2.1
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.3	-0.4	0.1	0.2	0.0	-0.2	0.3
Smoking status: Previous	0.9	1.3	3.3	0.3	1.6	-1.8	1.0	-1.2	0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.3	-1.4	0.1	-1.1	-2.1	-1.5	1.6	-1.8
Whole body fat-free mass	4.5	25.9	45.4	-2.7	0.5	-5.1	-4.6	-6.7	6.1	-6.7
Leg fat-free mass (right)	4.4	23.4	41.9	-2.4	-0.0	-5.0	-4.8	-6.5	5.5	-6.2
Arm fat percentage (left)	0.2	0.7	1.7	1.3	0.2	0.1	0.6	1.0	-1.3	0.5
Average weekly red wine intake	0.3	0.5	1.1	-1.0	-0.6	-0.0	0.4	0.1	-0.8	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	1.3	1.4	0.6	0.0	0.3	1.0	0.2
Mood swings	0.9	1.6	2.6	-1.6	1.1	1.4	-0.9	1.1	-1.1	1.3
Loneliness, isolation	1.3	1.8	3.0	-0.9	-0.5	1.5	1.3	1.7	-1.5	1.5
Long-standing illness, disability or infirmity	0.6	0.8	3.0	-0.6	-1.7	1.3	-0.2	0.6	-0.4	-0.5
Ever had bowel cancer screening	4.7	5.4	10.5	0.4	-0.1	-2.3	-1.7	-3.1	3.2	-3.2
Diabetes diagnosed by doctor	0.8	1.3	2.2	-1.1	1.0	0.9	0.2	1.3	-1.5	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.5	-0.1	1.1	-1.2	0.9	-1.0	0.9	-0.8
Friendships satisfaction	0.5	0.6	2.0	-0.8	-0.4	0.3	-0.3	-0.4	1.2	-1.4
Qualifications: nursing, teaching	0.7	1.2	3.5	-1.2	-1.9	1.5	-0.3	0.9	-0.1	0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.1	0.5	-0.0	0.2	0.2	-0.2	0.2
Eye problems/disorders: Cataract	0.9	1.0	3.9	1.3	0.7	-2.0	0.1	-0.8	0.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.5	0.0	-0.7	0.2	0.4	-0.0	0.4	0.2
Medication for cholesterol	0.2	0.3	1.0	1.0	-0.3	-0.1	0.5	0.1	-0.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	3.7	-0.6	0.1	0.1	1.9	0.4	-0.3	0.4
Back pain experienced in last month	0.7	1.0	2.6	1.6	0.9	-1.0	0.2	-0.8	1.2	-0.8
Mineral and other dietary supplements	1.4	1.8	4.8	0.1	0.1	1.5	0.2	1.7	-2.2	1.7
Breast cancer (self-reported)	1.1	1.3	3.1	-0.0	0.1	-1.5	0.7	-1.8	1.2	-1.3
Asthma (self-reported)	0.2	0.3	1.2	-0.3	-0.3	-0.3	0.7	-0.2	-0.6	1.1
Osteoporosis (self-reported)	1.5	1.8	4.1	-0.3	-0.4	1.7	-0.1	2.0	-1.7	1.6
Osteoarthritis (self-reported)	0.6	0.8	2.4	-0.2	-0.4	-1.5	-0.1	-1.3	0.3	-1.1
Medication: Aspirin	1.4	1.8	4.3	-0.7	-0.8	1.3	0.6	2.0	-2.1	1.3
Medication: Gliclazide	1.1	1.3	3.8	-0.1	0.0	-1.9	0.4	-1.6	1.3	-0.8
Illnesses of father: None of the above (group 1)	0.7	0.9	2.3	0.9	0.8	-1.2	-0.3	-1.5	0.2	-0.9
Smoking status: Current	0.5	0.7	2.4	-0.5	-0.5	0.8	0.3	0.9	-1.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	14.7	3.8	1.6	-0.9	1.2	0.7	-0.6	1.2
Whole body water mass	4.6	26.3	46.4	-2.8	0.5	-5.1	-4.7	-6.7	6.1	-6.8
Leg predicted mass (right)	4.3	23.0	41.7	-2.4	-0.0	-5.0	-4.6	-6.5	5.5	-6.1
Arm fat mass (left)	0.2	0.9	2.6	0.6	0.0	-1.4	-0.6	-0.9	0.5	-1.6
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	-0.9	-1.0	-0.6	-0.8	-0.5	0.2	-1.1
Average weekly champagne plus white wine intake	1.6	2.2	4.8	-2.2	1.3	0.4	-0.4	1.2	-1.6	2.2
Miserableness	0.3	0.6	2.1	0.4	-0.5	1.5	-0.5	0.4	1.0	-0.4
Guilty feelings	1.0	1.5	2.8	0.1	1.3	1.6	1.3	1.7	-0.8	0.8
Wears glasses or contact lenses	0.3	0.3	1.4	-1.2	-0.2	0.6	-0.3	-0.0	0.1	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.8	0.1	-0.9	0.4	-0.4	0.2	0.2	-0.3
Hearing aid user	1.1	1.3	6.7	-2.6	0.4	0.6	-1.0	0.1	-0.6	-0.1
Mother’s age at death	1.6	2.0	4.2	0.6	1.5	-2.0	1.1	-1.6	1.3	-1.4
Financial situation satisfaction	1.8	2.3	6.8	2.6	-0.3	0.8	2.2	1.4	-0.5	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.4	-0.7	-1.5	0.4	0.3	-0.1	0.1	0.9
Commuting to job workplace: Public transport	1.4	1.6	3.2	-0.2	-0.9	-1.4	-0.5	-1.8	1.4	-1.8
Eye problems/disorders: Glaucoma	0.8	0.9	4.0	1.0	0.7	0.1	2.0	0.6	-0.6	0.2
Medication: Blood pressure	0.8	1.4	3.1	-1.8	0.3	0.0	-1.3	-1.0	1.2	-1.6
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.2	-1.0	-0.2	-1.5	-1.8	-1.7	1.1	-1.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.7	0.8	0.2	-1.9	0.8	-1.2	1.0	-1.1
High cholesterol (Self-reported)	0.2	0.4	2.2	-0.6	-1.5	-0.3	0.5	0.3	0.1	-0.1
Medication: Bendroflumethiazide	0.8	1.3	2.2	-1.0	-1.0	0.8	-1.1	-0.9	1.5	-1.4
Medication: Paracetamol	0.4	0.6	3.5	1.9	0.2	-0.3	0.5	-0.3	0.2	-0.3
Medication: Lisinopril	0.8	1.1	4.2	-0.7	-2.1	0.9	0.0	-0.2	1.1	-1.0
Medication: Atorvastatin	0.5	0.6	2.5	-0.6	-0.4	-1.6	0.8	-0.6	-0.4	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.7	1.3	-0.4	-0.5	0.3	0.5	-0.6	0.9
Alcohol drinker status: Never	0.4	0.5	1.2	-0.3	0.9	0.1	-1.1	0.7	-0.9	0.1
Ever smoked	0.2	0.4	1.3	-1.1	0.2	-0.7	0.0	-0.9	0.1	-0.1
Basal metabolic rate	3.8	21.1	38.1	-2.4	0.3	-4.7	-4.3	-5.9	5.3	-6.2
Leg fat percentage (left)	0.6	2.3	4.6	2.1	0.3	0.9	1.5	2.1	-1.7	1.1
Arm fat-free mass (left)	3.6	18.1	36.0	-1.8	-0.1	-4.4	-3.4	-5.4	5.2	-6.0
Number of operations (self-reported)	1.5	2.2	4.7	-2.2	0.4	-0.8	-0.5	-1.7	1.7	-1.9
Average weekly beer plus cider intake	1.0	1.4	3.0	0.5	-0.4	1.7	1.2	1.5	-1.1	1.2
Irritability	0.9	1.5	6.7	-0.3	0.6	2.6	-1.4	1.2	0.3	-0.0
Risk taking	0.3	0.4	1.4	0.5	0.1	1.2	0.8	0.5	0.4	0.5
Ever had prostate specific antigen (PSA) test	1.7	2.0	6.5	0.7	0.7	-2.5	0.2	-2.0	1.3	-0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.7	-0.7	0.4	-1.3	0.1	-0.8	-0.5	-0.4
Age started oral contraceptive pill	0.5	0.7	1.6	-1.1	-1.3	-0.8	-0.4	-0.7	0.6	-0.6
Diastolic blood pressure, automated reading	0.2	0.7	2.9	1.7	0.3	1.0	0.4	0.8	-0.1	0.6
Ever depressed for a whole week	1.6	2.0	4.4	0.2	-0.7	2.1	1.9	1.7	-0.6	1.4
Unable to work because of sickness or disability	1.4	1.8	5.8	0.7	-1.3	0.2	0.1	1.7	-2.4	1.2
Commuting to job workplace: Cycle	0.3	0.3	1.7	-0.4	-1.3	0.0	-0.4	0.1	-0.4	0.0
Myopia	2.9	4.2	8.0	-0.4	0.8	-1.8	-2.0	-2.7	2.8	-2.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	0.6	1.1	-0.7	0.1	-0.5	0.4	-0.0
Cholesterol lowering medication	0.2	0.2	0.8	-0.2	-0.9	0.3	0.7	0.3	-0.4	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	0.2	-1.3	-1.3	-0.9	-0.9	0.2	-0.8
Pain experienced in last month	1.3	2.1	6.4	-0.1	-0.6	1.1	0.1	1.9	-2.5	1.8
Supplements: Calcium	1.3	1.4	5.9	-0.4	-1.0	2.4	-0.9	1.3	-0.4	0.4
Basal cell carcinoma (self-reported)	1.5	1.8	8.8	0.1	0.2	-3.0	-0.1	-1.9	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	3.0	3.9	6.1	-1.9	0.0	2.1	1.7	2.5	-2.2	2.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	5.0	-0.2	0.9	0.6	2.2	1.0	-0.3	0.4
Heart disease (siblings)	0.8	1.0	4.6	-0.7	-2.1	0.3	-1.0	0.7	-0.7	0.2
Alcohol drinker status: Previous	2.1	2.4	4.5	-0.4	-1.8	0.9	1.2	1.8	-2.1	1.9
Pack years of smoking	2.2	3.2	10.0	-0.6	-0.6	1.7	0.2	2.1	-3.2	2.1
Impedance of whole body	2.4	12.2	22.1	-1.3	0.9	4.5	1.6	4.6	-4.1	4.7
Leg fat mass (left)	0.1	0.4	1.1	0.7	0.4	-0.9	-0.2	-0.3	0.1	-1.0
Arm predicted mass (left)	3.5	18.0	35.2	-1.8	0.1	-4.4	-3.5	-5.4	5.1	-5.9