Best TWAS P=9.32e-23 · Best GWAS P=6.05e-56 conditioned to 1.18e-29
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | -6.1 | 5.7 | 1.1e-08 | 0.07 | 0.08 | 0.06 | FALSE |
| 2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | -8.1 | -6.8 | 1.5e-11 | -0.21 | 0.38 | 0.03 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | LYN | 0.35 | 0.07 | enet | 37 | 0.17 | 4.5e-06 | 15.4 | -8.7 | 3.0e-18 | -0.47 | 0.00 | 0.97 | TRUE |
| 4 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | -8.1 | -7.7 | 1.3e-14 | -0.18 | 0.60 | 0.02 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | -7.9 | -9.8 | 9.3e-23 | -0.21 | 0.27 | 0.03 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RPS20 | 0.24 | 0.20 | lasso | 6 | 0.23 | 3.4e-29 | -6.3 | -5.4 | 6.8e-08 | -0.13 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | -5.0 | 5.8 | 8.5e-09 | 0.17 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PENK | 0.03 | 0.01 | blup | 40 | 0.03 | 9.1e-04 | -6.3 | -8.9 | 3.9e-19 | -0.21 | 0.02 | 0.72 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PENK | 0.03 | 0.04 | enet | 7 | 0.05 | 6.2e-10 | 9.5 | -9.4 | 4.0e-21 | -0.23 | 0.01 | 0.99 | TRUE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | PENK | 0.11 | 0.13 | lasso | 2 | 0.14 | 2.6e-08 | -6.3 | -7.2 | 6.9e-13 | -0.15 | 0.59 | 0.39 | FALSE |
| 11 | The Cancer Genome Atlas | Esophageal Carcinoma | PENK | 0.35 | 0.21 | enet | 12 | 0.33 | 3.8e-11 | 9.2 | -8.9 | 7.3e-19 | -0.21 | 0.03 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PENK | 0.07 | 0.06 | enet | 8 | 0.08 | 2.4e-09 | -6.1 | -8.2 | 2.0e-16 | -0.19 | 0.62 | 0.38 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS20 | 0.04 | 0.02 | blup | 29 | 0.03 | 4.8e-04 | -6.0 | -5.2 | 2.0e-07 | -0.10 | 0.03 | 0.03 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | -6.3 | -8.4 | 5.4e-17 | -0.31 | 0.96 | 0.03 | FALSE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PENK | 0.23 | 0.15 | lasso | 5 | 0.22 | 8.2e-10 | 9.4 | -9.1 | 1.1e-19 | -0.20 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PENK | 0.03 | 0.02 | enet | 5 | 0.03 | 1.9e-04 | -4.4 | -6.0 | 2.1e-09 | -0.27 | 0.06 | 0.40 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | -6.3 | -6.0 | 2.2e-09 | -0.17 | 0.15 | 0.05 | FALSE |
| 18 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PENK | 0.18 | 0.11 | lasso | 1 | 0.09 | 3.4e-03 | -6.3 | -6.3 | 2.4e-10 | -0.12 | 0.02 | 0.13 | FALSE |
| 19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PENK | 0.07 | 0.08 | lasso | 2 | 0.06 | 2.0e-05 | -6.1 | -6.1 | 8.4e-10 | -0.10 | 0.82 | 0.14 | FALSE |