Best TWAS P=3.5e-12 · Best GWAS P=7.82e-16 conditioned to 4.99e-15
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | -5.1 | 6.2 | 6.1e-10 | 0.03 | 0.83 | 0.14 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | 6.9 | 6.4 | 1.2e-10 | 0.05 | 0.79 | 0.06 | FALSE |
3 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | 6.9 | 6.9 | 4.9e-12 | 0.04 | 0.74 | 0.20 | FALSE |
4 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | 6.1 | 6.2 | 4.3e-10 | 0.03 | 0.59 | 0.09 | FALSE |
5 | GTEx | Brain Hypothalamus | CCDC171 | 0.32 | 0.17 | enet | 6 | 0.09 | 4.0e-03 | 6.9 | 6.2 | 5.0e-10 | 0.04 | 0.26 | 0.12 | FALSE |
6 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | 7.2 | 7.0 | 3.5e-12 | 0.03 | 0.67 | 0.33 | TRUE |
7 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | -5.6 | 6.0 | 2.1e-09 | 0.04 | 0.71 | 0.06 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | -5.2 | 5.4 | 6.7e-08 | 0.06 | 1.00 | 0.00 | FALSE |