[Hub]/) : Traits : Sitting height : ← →

chr10:4,236,655-5,844,628

Best TWAS P=1.04e-33 · Best GWAS P=3.19e-33 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AKR1C1	0.30	0.16	bslmm	703	0.18	3.5e-21	3.3	7.2	4.7e-13	-0.55	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	AKR1C2	0.31	0.06	bslmm	665	0.16	2.1e-19	2.6	-8.2	1.6e-16	0.74	0.10	0.90	FALSE
3	GTEx	Adrenal Gland	AKR1C1	0.33	0.08	enet	11	0.07	1.8e-03	4.2	-5.3	8.9e-08	0.42	0.49	0.04	FALSE
4	GTEx	Artery Tibial	AKR1C2	0.14	0.10	enet	10	0.15	1.2e-11	-11.9	-11.3	8.8e-30	0.94	0.00	1.00	FALSE
5	GTEx	Brain Cerebellar Hemisphere	AKR1C1	0.46	0.14	lasso	4	0.23	1.4e-06	-6.2	10.3	7.5e-25	-0.85	0.01	0.96	FALSE
6	GTEx	Brain Cerebellum	AKR1C2	0.27	0.04	enet	12	0.11	4.1e-04	-11.9	-7.0	1.8e-12	0.68	0.01	0.97	FALSE
7	GTEx	Brain Cortex	AKR1C2	0.49	0.10	lasso	11	0.26	1.1e-07	-12.0	-10.0	1.6e-23	0.85	0.00	0.98	FALSE
8	GTEx	Brain Hippocampus	AKR1C2	0.35	0.13	lasso	9	0.16	1.3e-04	-6.5	-6.3	3.9e-10	0.49	0.07	0.78	FALSE
9	GTEx	Cells Transformed fibroblasts	AKR1C2	0.28	0.23	lasso	6	0.21	1.9e-15	-12.0	-12.1	1.0e-33	1.00	0.00	1.00	TRUE
10	GTEx	Esophagus Muscularis	AKR1C2	0.30	0.21	lasso	2	0.19	8.5e-12	-12.0	-12.0	3.6e-33	1.00	0.00	1.00	FALSE
11	GTEx	Heart Atrial Appendage	AKR1C2	0.28	0.37	lasso	3	0.29	1.2e-13	-11.9	-11.9	1.7e-32	0.98	0.00	1.00	FALSE
12	GTEx	Muscle Skeletal	AKR1C2	0.11	0.03	enet	9	0.05	2.0e-05	-1.8	7.2	4.8e-13	-0.55	0.06	0.84	FALSE
13	GTEx	Ovary	AKR1C3	0.35	0.20	lasso	9	0.22	3.9e-06	-12.0	-11.5	8.1e-31	0.91	0.00	0.97	FALSE
14	GTEx	Skin Sun Exposed Lower leg	AKR1C2	0.17	0.18	lasso	2	0.18	4.0e-15	-11.9	-12.0	4.8e-33	1.00	0.00	1.00	FALSE
15	GTEx	Testis	AKR1C2	0.44	0.36	lasso	4	0.36	8.5e-17	-12.0	-11.8	3.2e-32	1.00	0.00	1.00	FALSE
16	GTEx	Testis	AKR1C1	0.28	0.04	enet	39	0.07	3.7e-04	-11.8	8.9	7.3e-19	-0.62	0.01	0.94	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	AKR1C2	0.56	0.40	enet	28	0.46	1.0e-65	-12.0	-11.5	9.0e-31	0.93	0.00	1.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	AKR1C1	0.39	0.28	lasso	6	0.32	9.1e-42	3.3	6.7	1.7e-11	-0.61	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	AKR1C1	0.01	0.00	blup	81	0.01	7.5e-03	4.4	-5.6	1.8e-08	0.43	0.03	0.39	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C1	0.07	0.04	enet	10	0.02	1.0e-03	-11.8	11.2	3.1e-29	-0.88	0.00	0.98	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C2	0.12	0.11	lasso	6	0.09	1.6e-10	-12.0	-12.0	3.8e-33	1.00	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1C1	0.15	0.02	blup	81	0.06	2.0e-04	3.3	6.7	1.6e-11	-0.59	0.00	0.86	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1C2	0.29	0.21	lasso	1	0.21	4.7e-12	-11.9	-11.9	1.9e-32	0.98	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKR1C2	0.09	0.05	blup	62	0.05	3.4e-06	-11.8	-10.7	1.4e-26	0.89	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	AKR1C2	0.39	0.18	enet	14	0.23	2.5e-23	-12.0	-10.9	1.6e-27	0.85	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Soft Tissue Sarcoma	AKR1C2	0.07	0.04	enet	5	0.06	1.1e-04	-6.2	-9.1	6.8e-20	0.74	0.02	0.79	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	AKR1C2	0.09	0.08	lasso	3	0.08	7.2e-08	-11.8	-11.3	1.5e-29	0.90	0.00	1.00	FALSE