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chr10:27,265,641-29,671,014

Best TWAS P=3.87e-12 · Best GWAS P=3.62e-14 conditioned to 1.12e-16

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	WAC-AS1	0.39	0.46	lasso	5	0.45	1.1e-40	6.0	5.7	9.4e-09	-0.08	0.48	0.52	FALSE
2	GTEx	Adipose Visceral Omentum	WAC-AS1	0.21	0.17	enet	16	0.18	2.0e-09	6.0	6.2	6.9e-10	-0.08	0.14	0.86	FALSE
3	GTEx	Adrenal Gland	WAC-AS1	0.28	0.19	lasso	4	0.14	7.2e-06	6.0	6.4	1.8e-10	-0.07	0.22	0.74	FALSE
4	GTEx	Artery Aorta	WAC-AS1	0.39	0.38	lasso	6	0.38	3.1e-22	6.0	5.8	7.7e-09	-0.08	0.49	0.51	FALSE
5	GTEx	Artery Coronary	WAC-AS1	0.41	0.21	lasso	6	0.19	4.0e-07	6.0	6.9	3.9e-12	-0.06	0.11	0.88	TRUE
6	GTEx	Artery Tibial	WAC	0.10	0.00	enet	32	0.00	5.6e-01	-5.5	-5.8	8.0e-09	0.09	0.05	0.40	FALSE
7	GTEx	Artery Tibial	WAC-AS1	0.44	0.43	lasso	4	0.44	4.0e-37	5.8	5.8	8.2e-09	-0.09	0.58	0.42	FALSE
8	GTEx	Brain Hippocampus	WAC-AS1	0.29	0.01	enet	10	-0.01	8.5e-01	6.4	6.2	7.4e-10	-0.09	0.06	0.32	FALSE
9	GTEx	Breast Mammary Tissue	WAC-AS1	0.29	0.32	lasso	2	0.31	2.1e-16	6.0	6.0	1.7e-09	-0.07	0.45	0.55	FALSE
10	GTEx	Breast Mammary Tissue (Female)	WAC-AS1	0.30	0.30	enet	13	0.33	1.7e-10	6.0	5.3	1.1e-07	-0.07	0.26	0.74	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	WAC-AS1	0.45	0.36	enet	12	0.41	1.1e-14	6.0	6.2	5.1e-10	-0.09	0.21	0.79	FALSE
12	GTEx	Cells Transformed fibroblasts	WAC-AS1	0.58	0.62	lasso	12	0.64	9.7e-62	6.0	6.1	8.6e-10	-0.08	0.47	0.53	FALSE
13	GTEx	Colon Sigmoid	WAC-AS1	0.36	0.23	lasso	9	0.22	2.6e-08	5.8	6.4	1.3e-10	-0.06	0.49	0.50	FALSE
14	GTEx	Colon Transverse	WAC-AS1	0.36	0.17	enet	16	0.31	3.6e-15	6.0	6.1	1.0e-09	-0.09	0.37	0.63	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	WAC-AS1	0.37	0.16	lasso	6	0.20	9.1e-08	6.4	6.6	4.8e-11	-0.08	0.08	0.92	FALSE
16	GTEx	Esophagus Mucosa	WAC-AS1	0.52	0.44	lasso	16	0.51	1.2e-38	6.0	5.8	8.0e-09	-0.08	0.47	0.53	FALSE
17	GTEx	Esophagus Muscularis	WAC-AS1	0.37	0.29	enet	32	0.38	5.5e-24	6.0	5.7	1.2e-08	-0.14	0.24	0.76	FALSE
18	GTEx	Heart Atrial Appendage	WAC-AS1	0.18	0.12	enet	6	0.15	2.5e-07	5.8	6.8	1.2e-11	-0.08	0.22	0.77	FALSE
19	GTEx	Heart Left Ventricle	WAC-AS1	0.39	0.08	lasso	8	0.20	1.3e-10	6.0	5.4	6.3e-08	-0.08	0.31	0.68	FALSE
20	GTEx	Liver	WAC-AS1	0.37	0.34	lasso	3	0.34	3.1e-10	6.0	5.8	6.5e-09	-0.07	0.21	0.79	FALSE
21	GTEx	Lung	WAC-AS1	0.32	0.13	enet	26	0.24	4.7e-18	6.0	6.2	5.2e-10	-0.08	0.14	0.86	FALSE
22	GTEx	Nerve Tibial	WAC-AS1	0.45	0.55	lasso	5	0.56	1.4e-46	6.0	5.8	5.4e-09	-0.07	0.49	0.51	FALSE
23	GTEx	Pancreas	WAC-AS1	0.45	0.33	lasso	8	0.34	6.4e-15	6.0	6.0	1.5e-09	-0.08	0.15	0.85	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	WAC-AS1	0.48	0.48	enet	37	0.56	6.1e-37	5.8	5.7	1.0e-08	-0.07	0.50	0.50	FALSE
25	GTEx	Stomach	WAC-AS1	0.39	0.31	lasso	8	0.33	1.1e-16	6.0	6.0	1.7e-09	-0.08	0.22	0.78	FALSE
26	GTEx	Testis	WAC-AS1	0.45	0.47	lasso	3	0.48	4.3e-24	6.0	6.0	2.0e-09	-0.07	0.51	0.49	FALSE
27	GTEx	Vagina	WAC-AS1	0.55	0.25	lasso	5	0.22	1.0e-05	5.8	6.9	4.0e-12	-0.14	0.16	0.75	FALSE
28	METSIM	Adipose	MKX	0.08	0.10	lasso	5	0.09	2.4e-13	5.6	-6.0	2.2e-09	-0.17	1.00	0.00	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	BAMBI	0.07	0.05	lasso	3	0.04	2.8e-06	5.7	6.5	5.7e-11	-0.07	0.12	0.87	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	WAC	0.21	0.29	lasso	5	0.29	5.9e-37	6.4	6.7	1.6e-11	-0.06	0.06	0.94	FALSE
31	YFS	Blood	WAC	0.06	0.08	bslmm	649	0.08	2.2e-24	6.5	-6.2	4.4e-10	0.04	0.05	0.95	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	WAC	0.06	0.04	lasso	3	0.03	4.2e-04	6.4	6.5	9.3e-11	-0.05	0.04	0.82	FALSE