TWAS hub - MKX

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1050	0.0320	1.8e-04	0.011	0.059	0.042	0.058	0.031	1.6e-02	9.9e-08	6.5e-06	1.2e-07	8.9e-05
2	METSIM	Adipose	0.0766	0.0198	4.0e-09	0.099	0.072	0.084	0.080	0.090	1.4e-14	7.0e-11	1.3e-12	5.2e-12	2.4e-13
3	ROSMAP	Brain Pre-frontal Cortex	0.0795	0.0244	6.5e-06	0.035	0.036	0.034	0.035	0.046	2.2e-05	1.9e-05	2.8e-05	2.2e-05	1.4e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel T-Score	4.9	39.3	67.1	-3.9	-8.2	6.0
Waist Hip Ratio (WHR)	4.7	21.1	47.7	1.1	6.9	-3.8
Back pain experienced in last month	4.2	6.2	17.0	-0.1	-4.1	1.2
Ever highly irritable/argumentative for 2 days	3.9	4.7	7.6	1.5	2.8	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	15.2	-0.2	-3.9	3.3
Length of working week for main job	3.8	4.2	8.3	-1.6	-2.9	1.4
Other serious medical condition/disability diagnosed by doctor	3.4	4.4	8.5	-0.7	-2.9	2.1
Pain experienced in last month	3.3	5.5	10.2	0.8	3.2	-2.4
Townsend deprivation index at recruitment	3.1	4.4	8.1	0.7	2.9	-2.1
Heart attack	3.1	3.9	4.7	1.9	2.2	-1.8
Reaction Time	2.9	5.5	12.6	-3.5	-0.3	1.9
Heart attack/myocardial infarction (self-reported)	2.9	3.7	4.2	2.0	2.0	-1.7
Alzheimer’s Disease (in mother)	2.8	3.3	3.4	-1.8	-1.9	1.8
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	5.4	-1.4	-2.3	1.8
Falls in the last year	2.7	3.6	6.3	-1.6	-2.5	1.4
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	10.6	-0.3	-3.3	2.7
Long-standing illness, disability or infirmity	2.6	3.9	7.7	-0.8	-1.8	2.8
Schizophrenia vs Biploar Disorder	2.5	3.3	4.8	0.6	-2.1	2.2
Birth weight	2.5	5.5	8.9	-1.8	-3.0	2.0
Lupus	2.4	3.6	7.4	1.2	1.4	-2.7
Leg fat-free mass (left)	2.4	12.6	27.4	0.3	-5.2	3.2
Leg predicted mass (left)	2.4	12.6	27.5	0.2	-5.2	3.2
Lung cancer (father)	2.4	2.8	4.8	-0.3	-2.2	1.9
Ulcerative Colitis	2.3	3.3	4.9	-1.2	-2.2	1.9
Impedance of leg (left)	2.3	11.3	20.2	-1.4	4.5	-3.4
Leg fat-free mass (right)	2.3	12.1	27.1	0.5	-5.2	3.0
Leg predicted mass (right)	2.3	12.2	27.6	0.4	-5.3	3.0
Medication: Seretide 50 evohaler	2.2	2.5	3.3	1.2	-1.8	1.6
Supplements: Vitamin C	2.2	2.6	3.7	-0.8	-1.9	1.9
Impedance of leg (right)	2.1	10.1	17.9	-1.7	4.2	-3.1
High blood pressure (mother)	2.1	3.0	6.6	1.3	2.6	-0.8
Cardiovascular Disease	2.0	6.6	13.5	1.6	3.7	-2.0
Average weekly fortified wine intake	2.0	2.4	5.4	-1.2	-2.3	0.6
Sitting height	2.0	14.0	35.8	-2.2	-6.0	1.2
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	3.9	-0.4	-2.0	1.8
Financial situation satisfaction	2.0	2.5	7.3	-0.4	2.7	-0.3
Commuting to job workplace: Cycle	2.0	2.4	4.7	-2.2	-0.5	1.5
Hip circumference	1.9	8.3	18.0	0.4	-4.2	2.6
Depression (self-reported)	1.9	2.3	2.4	-1.5	-1.4	1.6
Arm fat-free mass (right)	1.9	9.7	23.4	0.0	-4.8	2.4
Arm predicted mass (right)	1.9	9.8	23.6	-0.1	-4.9	2.4
Whole body fat-free mass	1.9	10.8	25.6	-0.3	-5.1	2.6
Whole body water mass	1.9	11.0	26.0	-0.4	-5.1	2.6
Hearing difficulty/problems: Yes	1.8	2.8	5.0	1.8	2.2	-0.6
Serious illness, injury or assault to yourself	1.8	2.2	3.9	-1.6	-2.0	0.5
Had menopause	1.8	2.2	4.0	1.2	1.1	-2.0
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.5	-0.3	1.3	-2.1
Illnesses of father: High blood pressure	1.8	2.2	2.4	-1.5	1.4	-1.5
Basal metabolic rate	1.8	10.1	23.6	-0.0	-4.9	2.6
Prostate Cancer	1.7	2.5	5.6	-0.7	-1.1	2.4
Vitamin and mineral supplements	1.7	2.3	3.4	1.5	1.0	-1.9
Trunk predicted mass	1.7	9.7	24.3	-0.7	-4.9	2.1
Arm predicted mass (left)	1.7	8.5	19.9	-0.3	-4.5	2.3
Type 2 Diabetes (T2D) (2012)	1.6	1.8	4.0	2.0	0.9	0.8
Hearing difficulty/problems with background noise	1.6	2.6	6.4	2.5	1.1	-0.1
Trunk fat-free mass	1.6	9.4	23.3	-0.7	-4.8	2.1
Number of live births	1.6	2.3	2.5	1.5	1.6	-1.4
Eye problems/disorders: None of the above	1.6	1.8	3.1	1.8	1.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.0	1.5	1.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.0	-1.9	-2.2	1.1
Intelligence (Savage-Jansen 2018)	1.5	4.5	10.3	-3.2	0.9	-1.6
Alzheimer’s Disease (including proxy)	1.5	2.2	2.9	-1.2	-1.7	1.5
Breast Cancer	1.5	3.7	6.8	-2.1	2.6	0.2
Shortness of breath walking on level ground	1.5	1.8	4.8	-0.1	-0.7	2.2
Medication for cholesterol	1.5	2.3	5.6	-1.1	-2.4	0.2
Osteoarthritis (self-reported)	1.5	2.0	2.4	1.2	-1.4	1.6
Illnesses of father: None of the above (group 1)	1.5	1.9	2.8	0.7	-1.7	1.6
Arm fat-free mass (left)	1.5	7.7	18.2	-0.2	-4.3	2.2
Body Mass Index (BMI) (2010)	1.4	1.9	5.6	2.4	-0.2	0.0
Neuroticism (2016)	1.4	2.0	5.1	2.3	0.6	0.7
Age when periods started (menarche)	1.4	3.3	7.1	0.9	1.4	-2.7
Multivitamins +/- minerals	1.4	1.8	4.0	-0.8	-0.8	2.0
Medication: Atenolol	1.4	1.7	4.4	-0.7	-0.4	2.1
Pain all over the body in last month	1.4	1.5	1.7	-1.2	1.3	1.2
Alcohol intake versus 10 years previously	1.4	2.1	3.4	-1.1	-1.8	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.2	1.3	1.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.3	0.8	1.4	-1.5
Medication for hormone replacement therapy	1.3	1.4	2.2	1.2	1.5	-0.8
Weight	1.3	6.6	11.6	1.0	-3.4	2.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.3	1.8	-0.5	1.0
Arm fat mass (right)	1.3	5.4	7.5	1.9	-2.2	2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	4.4	-1.2	-0.6	2.1
Medication: Ibuprofen	1.3	1.6	3.5	-0.4	-1.9	1.0
Mean time to correctly identify matches	1.3	2.4	6.1	-2.5	0.3	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.7	1.9	0.5	0.8
Medication: Gliclazide	1.3	1.5	2.8	-0.4	1.7	-1.2
Medication: Blood pressure	1.3	2.5	6.4	1.0	2.5	0.4
Irritability	1.3	2.2	3.2	1.3	1.3	-1.8
Ever depressed for a whole week	1.3	1.5	4.2	2.1	-0.6	-0.0
Supplements: Calcium	1.3	1.4	3.1	-0.8	-1.8	0.7
Ulcerative Colitis (UC)	1.2	2.3	4.4	-0.3	-2.1	1.6
Height	1.2	22.6	48.3	-3.8	-7.0	2.2
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.3	-1.4	-1.2	1.5
Leg pain on walking	1.2	1.5	4.1	-0.2	-0.7	2.0
Wears glasses or contact lenses	1.2	1.4	3.8	-2.0	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.9	-0.3	-2.0	-0.8
Medication: Atorvastatin	1.2	1.4	3.7	-0.1	0.8	-1.9
Bipolar Disorder (2011)	1.1	1.1	2.4	-1.5	-0.4	0.8
Systolic Blood Pressure	1.1	5.6	15.2	-0.1	3.9	-1.2
Taking other prescription medications	1.1	1.7	3.3	0.2	-1.4	1.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.4	1.1	1.6	-0.6
Medication: Amlodipine	1.1	1.5	3.0	0.9	1.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.4	0.7	0.3	-1.9
Medication: Allopurinol	1.1	1.4	2.6	1.2	0.4	-1.6
Arm fat mass (left)	1.1	4.3	5.4	1.8	-2.1	2.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.8	-1.9	0.6	-1.7
BMI	1.0	5.8	6.7	2.4	-2.2	2.6
Supplements: Zinc	1.0	1.0	1.8	-1.1	-1.3	0.4
Medication: Levothyroxine sodium	1.0	1.6	4.2	-0.8	-0.3	2.0
Body mass index (BMI)	1.0	4.4	6.1	2.2	-1.6	2.5
Qualifications: None of the above	1.0	2.1	5.5	2.4	0.8	-0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.1	-0.7	0.6	1.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.0	1.4	-1.2	0.5
Family relationship satisfaction	1.0	1.2	3.4	-1.9	0.1	-0.6
Arm fat percentage (left)	1.0	4.1	5.9	2.4	-0.9	2.3
Impedance of whole body	1.0	5.1	10.7	-1.1	3.3	-1.9
Major Depression (MDD)	0.9	1.1	2.4	0.9	1.5	-0.5
Hand grip strength (left)	0.9	2.5	5.8	0.1	-2.4	1.3
Relative age of first facial hair	0.9	1.8	4.3	0.5	-2.1	-1.0
Medication: Co-codamol	0.9	1.0	1.6	1.3	-0.8	0.9
Relative age voice broke	0.9	1.4	2.5	1.1	-0.7	-1.6
Hair/balding pattern: Pattern 2	0.9	1.2	2.8	0.7	1.7	0.6
Arm fat percentage (right)	0.9	3.6	5.2	2.3	-0.7	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.5	-0.7	-2.6	1.4
Standing height	0.9	9.3	20.5	-2.5	-4.5	1.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.8	1.1	0.6	2.0
Forced vital capacity (FVC), Best measure	0.9	3.2	8.2	-0.4	-2.9	1.1
Number of full brothers	0.9	1.1	3.0	0.4	-0.2	1.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	0.1	0.6	-1.7
Diabetes diagnosed by doctor	0.9	1.5	3.2	0.7	1.8	-0.9
Hearing aid user	0.9	1.0	2.4	-1.5	0.7	-0.2
Myopia	0.9	1.4	2.2	-0.5	1.3	-1.5
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.8	-0.6	-2.6	0.5
Basal cell carcinoma (self-reported)	0.9	1.1	2.5	-0.4	0.7	1.6
Bipolar Disorder (2018)	0.8	1.2	1.8	-1.2	1.3	-0.6
Systolic blood pressure, automated reading	0.8	2.2	5.8	-0.0	2.4	-1.0
Diabetes (father)	0.8	0.9	2.7	1.6	0.3	-0.2
Hand grip strength (right)	0.8	2.0	4.3	-0.4	-2.1	1.3
High blood pressure	0.8	2.1	6.1	0.5	2.5	-0.2
Trunk fat mass	0.8	3.4	4.6	1.6	-1.7	2.1
Medication: Ramipril	0.8	1.0	2.2	0.7	1.5	0.5
Impedance of arm (right)	0.8	3.6	9.3	-0.8	3.0	-1.0
Pulse rate	0.8	1.4	3.5	-1.9	-0.4	0.8
Happiness	0.8	1.0	1.9	0.8	1.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-0.9	-2.1	-0.1
Birth weight of first child	0.8	1.4	2.8	-0.9	-1.7	-0.8
Loud music exposure frequency	0.8	0.8	1.1	1.1	-0.8	0.9
Worry too long after embarrassment	0.8	1.3	2.8	1.0	-1.7	-0.3
Medication: Omeprazole	0.8	1.0	2.0	1.4	-0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	-1.3	0.2	-1.1
Whole body fat mass	0.8	3.4	4.4	1.6	-1.8	2.1
Hypertension (Self-reported)	0.8	2.2	6.6	0.3	2.6	-0.1
Loneliness, isolation	0.8	1.1	2.9	-1.7	0.6	0.1
Eye problems/disorders: Cataract	0.8	0.9	2.2	-0.4	0.6	-1.5
Number of self-reported non-cancer illnesses	0.8	1.4	3.3	-0.0	-0.9	1.8
Medication: Lisinopril	0.8	1.1	2.8	-0.0	1.7	0.7
Fractured/broken bones in last 5 years	0.8	1.1	1.5	1.2	-1.2	0.6
Diastolic blood pressure, automated reading	0.8	2.5	6.6	0.2	2.6	-1.0
Leg fat mass (left)	0.8	3.1	4.2	1.5	-1.7	2.1
Depression (Nagel 2018)	0.7	1.0	2.3	-0.8	1.5	-0.2
Schizophrenia (2018)	0.7	1.4	1.8	-0.9	-1.3	1.3
Crohns Disease (2017)	0.7	1.5	3.4	1.9	0.9	-0.5
Crohns Disease (2012)	0.7	1.2	1.9	0.8	0.9	-1.4
Lung FEV1/FVC ratio	0.7	3.5	6.2	-2.1	2.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.2	-0.0	-1.5	0.3
Diabetes (mother)	0.7	0.8	1.2	0.4	-1.1	1.1
Supplements: Glucosamine	0.7	0.9	2.3	-0.3	-1.5	0.5
Alcohol usually taken with meals	0.7	1.1	2.9	-0.0	-1.7	0.6
Forced vital capacity (FVC)	0.7	2.8	7.8	-0.4	-2.8	0.6
Blood clot in the leg (DVT)	0.7	0.9	2.3	0.2	-1.5	0.6
Headache pain in last month	0.7	1.3	2.7	-1.7	-0.7	0.8
Qualifications: College or University degree	0.7	2.3	4.8	-2.2	-1.4	-0.2
Leg fat mass (right)	0.7	2.8	3.9	1.3	-1.7	2.0
Comparative height size at age 10	0.7	4.0	8.9	-0.3	-3.0	1.7
Had major operations	0.7	0.8	1.0	0.8	-0.9	1.0
Illnesses of father: Heart disease	0.7	1.0	1.7	-0.5	1.3	-1.0
Average weekly beer plus cider intake	0.7	1.0	2.0	0.8	1.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.4	0.5	-1.5	0.4
Mean Putamen Volume	0.6	0.7	1.6	0.3	-1.3	0.6
Fasting Glucose	0.6	0.7	1.1	0.9	0.6	1.1
LDL Cholesterol	0.6	1.0	2.1	0.4	1.4	-0.9
Rheumatoid Arthritis	0.6	0.8	1.1	0.2	1.1	-1.1
Triglycerides	0.6	1.0	2.8	-0.2	1.7	-0.3
Average weekly spirits intake	0.6	0.8	2.1	0.3	0.3	1.5
Severe depression (siblings)	0.6	0.7	1.9	-1.4	0.1	0.5
Trunk fat percentage	0.6	2.3	3.5	1.9	-0.4	1.8
Had other major operations	0.6	0.7	1.2	-1.1	-1.0	0.2
Fluid intelligence score	0.6	1.2	2.0	-1.4	0.5	-1.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.8	-0.7	-2.2	0.8
Noisy workplace	0.6	0.7	1.6	0.2	0.8	1.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	-1.4	-0.5	-0.0
Exposure to tobacco smoke at home	0.6	0.7	2.0	0.1	0.0	1.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.1	0.8	-1.4	0.5
Gout (self-reported)	0.6	0.9	2.0	1.4	0.6	-0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.2	-1.1	-1.0	0.1
Body fat percentage	0.6	2.3	3.5	1.9	-0.3	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	0.7	0.1	1.4
Emphysema/chronic bronchitis	0.6	0.7	1.1	1.1	0.2	-1.0
Knee pain experienced in last month	0.6	0.9	1.5	0.8	-1.2	-0.8
Friendships satisfaction	0.6	0.8	1.0	0.9	1.0	-0.7
Osteoporosis (self-reported)	0.6	0.7	1.9	-1.4	0.1	-0.4
Average weekly champagne plus white wine intake	0.6	0.8	2.0	-1.4	-0.7	-0.1
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-1.4	-0.3	0.4
Medication: Bendroflumethiazide	0.6	0.9	1.7	0.9	1.3	0.3
Schizophrenia (2014)	0.5	1.1	1.7	-0.6	-1.3	1.1
Respiratory disease	0.5	1.0	2.8	0.6	0.0	1.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	-0.9	0.7	0.8
Pack years adult smoking proportion	0.5	0.7	1.3	0.7	-1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	-0.7	0.2	1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.2	-0.0	1.1	1.0
Financial difficulties in last 2 years	0.5	0.7	1.8	0.2	1.3	-0.4
Diabetes (self-reported)	0.5	0.7	1.7	0.3	1.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.5	0.5	-0.8	1.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	0.6	-0.6	-1.2
Asthma	0.5	1.0	2.7	-0.2	-0.5	1.6
Medication: Cholesterol lowering	0.5	0.8	1.1	-0.5	1.1	-1.1
Prospective memory result	0.5	0.6	0.8	0.9	0.4	-0.9
Illnesses of mother	0.5	0.7	1.4	-0.3	-1.2	0.6
Impedance of arm (left)	0.5	2.2	5.6	-0.3	2.4	-1.0
Wheeze or whistling in the chest in last year	0.5	0.9	1.8	0.6	-0.8	1.3
Health satisfaction	0.5	0.6	1.3	1.1	0.7	-0.2
Medication: Blood pressure	0.5	1.0	2.5	-0.3	1.6	0.5
Migraine (self-reported)	0.5	0.6	1.1	-0.6	-1.0	0.6
Suffer from ‘nerves’	0.5	0.7	1.8	-0.4	-0.5	1.3
Age at last live birth	0.5	0.7	1.8	-0.6	1.3	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.6	1.1	-0.6
Average weekly red wine intake	0.5	0.7	0.8	0.8	-0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	-0.9	-0.5	0.9
Commuting to job workplace: Walk	0.5	0.5	1.0	-1.0	-0.5	-0.5
Asthma (self-reported)	0.5	1.0	2.7	-0.1	-0.6	1.6
Heart disease (siblings)	0.5	0.6	1.6	1.3	0.2	-0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	2.1	-1.5	-0.2	0.7
Coronary Artery Disease (CAD)	0.4	0.4	0.9	0.6	0.3	1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.6	1.3	0.9	-0.1
Chronotype (morning person)	0.4	0.9	2.3	1.5	0.2	-0.6
Number of treatments/medications taken	0.4	0.7	1.5	0.7	-0.1	1.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-1.1	0.3	0.6
Current tobacco smoking	0.4	0.7	1.3	0.3	-0.9	1.1
Maternal smoking around birth	0.4	0.6	1.0	-0.5	-0.7	1.0
Fed-up feelings	0.4	0.7	1.7	0.5	1.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.9	0.5	1.0	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	-1.5	-0.1	-0.6
Stomach or abdominal pain in last month	0.4	0.6	0.9	1.0	0.5	0.7
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	-0.0	1.0	-0.6
Number of incorrect matches in round	0.4	0.6	1.7	-0.1	0.3	-1.3
Time employed in main current job	0.4	0.4	1.1	1.0	-0.4	-0.0
Father’s age at death	0.4	0.5	1.3	-0.0	-0.5	-1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.8	-0.4	-1.1
Tense / ‘highly strung’	0.4	0.7	2.0	1.4	-0.4	0.1
Glaucoma (self-reported)	0.4	0.5	0.8	-0.6	-0.9	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	0.8	0.6	-0.7
Age at first live birth	0.4	0.7	0.8	-0.7	0.8	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	-1.2	0.1	-0.7
Alcohol intake frequency.	0.4	0.8	2.1	-0.1	-0.6	1.4
Overall health rating	0.4	0.9	2.3	0.6	-0.4	1.5
Chest pain or discomfort	0.4	0.5	1.4	-1.2	-0.2	-0.4
Medication: Aspirin	0.4	0.5	0.8	0.9	0.8	-0.4
Illnesses of siblings: Diabetes	0.4	0.4	0.8	0.9	0.5	-0.4
Qualifications: nursing, teaching	0.4	0.7	1.9	1.4	-0.2	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	-0.6	1.1	0.3
Medication: Aspirin	0.4	0.6	0.9	0.9	0.7	-0.5
Ever taken oral contraceptive pill	0.4	0.4	1.2	-0.2	-0.3	-1.1
Leg fat percentage (left)	0.4	1.5	3.1	1.8	0.3	1.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	1.2	-0.2	0.2
Pack years of smoking	0.4	0.5	0.7	0.8	-0.8	0.5
Irritable Bowel Disease (IBD)	0.3	0.8	1.0	1.0	-0.9	0.8
Age at First Birth	0.3	0.5	0.9	-0.6	-0.3	1.0
Lung FVC	0.3	1.4	3.8	0.2	-2.0	0.6
Neuroticism	0.3	0.6	1.2	0.7	0.4	-1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.1	0.8	-0.6
Waist circumference	0.3	1.2	3.3	1.8	0.0	0.6
Past tobacco smoking	0.3	0.6	1.7	-0.1	-0.2	1.3
Medication: Simvastatin	0.3	0.5	0.8	0.1	-0.8	0.9
Illnesses of siblings	0.3	0.4	0.7	-0.9	-0.6	-0.4
Medication: Lansoprazole	0.3	0.3	0.7	-0.3	0.3	0.8
Breastfed as a baby	0.3	0.4	0.6	-0.7	-0.4	-0.8
Pulse wave reflection index	0.3	0.4	1.0	0.1	1.0	0.3
Leg fat percentage (right)	0.3	1.2	1.9	1.4	0.3	1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.5	0.7	0.6	0.5
Number of children fathered	0.3	0.3	0.6	0.8	0.4	-0.3
Pulse wave peak to peak time	0.3	0.4	1.1	1.1	0.1	0.0
Pulse rate, automated reading	0.3	0.9	1.1	-0.9	-0.8	1.1
Mineral and other dietary supplements	0.3	0.4	1.0	-0.0	1.0	-0.3
Guilty feelings	0.3	0.5	1.0	-1.0	-0.5	-0.4
Mother’s age at death	0.3	0.4	0.8	-0.5	0.2	-0.9
High cholesterol (Self-reported)	0.3	0.5	1.4	0.2	0.4	-1.2
Ever smoked	0.3	0.4	1.0	0.0	-0.6	-1.0
Number of operations (self-reported)	0.3	0.5	0.7	0.8	-0.6	0.7
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.9	0.4	0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	-0.3	1.2	-0.0
Neuroticism (Nagel 2018)	0.2	0.5	1.0	0.1	0.8	-1.0
Ovarian Cancer	0.2	0.3	0.4	-0.7	0.5	-0.3
HbA1C	0.2	0.2	0.5	-0.2	-0.7	0.0
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.7	-0.4	0.2
Blood White Count	0.2	1.3	2.8	-1.1	1.7	-0.1
Allergy or Eczema	0.2	0.6	1.7	-1.3	0.3	-0.3
Hair Pigment	0.2	6.4	12.5	1.0	3.5	-2.4
Sensitivity / hurt feelings	0.2	0.4	1.0	0.2	-1.0	-0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.5	0.3	0.4
Angina	0.2	0.3	0.7	-0.9	0.2	-0.0
Medication: Metformin	0.2	0.3	0.8	0.0	0.5	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.8	-0.2	0.4
Mouth/teeth dental problems	0.2	0.3	0.8	0.4	-0.9	-0.2
Worrier / anxious feelings	0.2	0.4	0.7	0.6	-0.3	0.8
High blood pressure (siblings)	0.2	0.3	0.6	0.4	0.5	0.8
Neck or shoulder pain in last month	0.2	0.3	0.4	0.6	0.6	-0.1
Angina (self-reported)	0.2	0.3	0.8	-0.9	0.1	0.1
Number of full sisters	0.2	0.3	0.5	0.7	0.5	0.3
Ever had bowel cancer screening	0.2	0.3	0.7	0.4	-0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	0.6	-0.5	1.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.5	0.4	-0.6
Medication: Paracetamol	0.2	0.3	0.3	0.5	0.5	-0.6
Alcohol drinker status: Never	0.2	0.3	0.7	-0.1	0.9	-0.3
Risk taking	0.2	0.2	0.3	0.4	-0.6	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.7	0.3	-0.1
Age started oral contraceptive pill	0.2	0.2	0.3	0.4	0.6	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	0.4	-0.5
Worry (Nagel 2018)	0.1	0.3	0.5	0.7	0.3	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	0.4	-0.1
HDL Cholesterol	0.1	0.1	0.4	0.2	-0.1	0.6
Blood Eosinophil Count	0.1	0.6	0.9	-1.0	-0.2	-1.0
Blood Platelet Count	0.1	1.2	2.9	-0.8	1.7	-0.1
Smoking Status	0.1	0.2	0.2	-0.4	-0.4	0.4
Hypothyroidism (self reported)	0.1	0.2	0.4	0.2	0.3	0.6
Tanning	0.1	0.8	2.2	1.5	0.2	-0.3
Nervous feelings	0.1	0.1	0.2	-0.1	0.2	0.5
Allergy	0.1	0.3	0.6	0.8	0.4	0.5
Neuroticism score	0.1	0.1	0.3	0.4	-0.5	-0.0
Medication: Paracetamol	0.1	0.2	0.4	-0.3	-0.6	0.3
Comparative body size at age 10	0.1	0.4	0.6	-0.8	-0.6	0.4
Heart disease (mother)	0.1	0.1	0.2	0.4	0.1	-0.3
Smoking status: Previous	0.1	0.1	0.4	-0.0	0.2	-0.6
Mood swings	0.1	0.2	0.6	0.3	0.8	-0.2
Smoking status: Current	0.1	0.2	0.3	0.0	-0.5	0.6
Miserableness	0.1	0.1	0.2	-0.3	0.2	0.5
Cholesterol lowering medication	0.1	0.2	0.5	0.7	0.0	0.2
Blood Red Count	0.0	0.4	0.8	0.7	0.9	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.4	-0.0	-0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.3	0.1	-0.4
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.1	0.2	-0.3
Breast cancer (self-reported)	0.0	0.1	0.1	0.2	-0.3	0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.1	-0.1	-0.2

Hub : Genes

MKX

Models

Trait associations