Hub : Genes

MKX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1050	0.0320	1.8e-04	0.011	0.059	0.042	0.058	0.031	1.6e-02	9.9e-08	6.5e-06	1.2e-07	8.9e-05
2	METSIM	Adipose	0.0766	0.0198	4.0e-09	0.099	0.072	0.084	0.080	0.090	1.4e-14	7.0e-11	1.3e-12	5.2e-12	2.4e-13
3	ROSMAP	Brain Pre-frontal Cortex	0.0795	0.0244	6.5e-06	0.035	0.036	0.034	0.035	0.046	2.2e-05	1.9e-05	2.8e-05	2.2e-05	1.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	1.8	-1.2	1.3	-0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.1	-1.5	-0.2	0.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	-0.3	1.2	-0.0
Depression (Nagel 2018)	0.7	1.0	2.3	-0.8	1.5	-0.2
Intelligence (Savage-Jansen 2018)	1.5	4.5	10.3	-3.2	0.9	-1.6
Neuroticism (Nagel 2018)	0.2	0.5	1.0	0.1	0.8	-1.0
Schizophrenia (2018)	0.7	1.4	1.8	-0.9	-1.3	1.3
Schizophrenia vs Biploar Disorder	2.5	3.3	4.8	0.6	-2.1	2.2
Worry (Nagel 2018)	0.1	0.3	0.5	0.7	0.3	-0.4
Alzheimer’s Disease (in mother)	2.8	3.3	3.4	-1.8	-1.9	1.8
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	0.4	-0.1
Alzheimer’s Disease (including proxy)	1.5	2.2	2.9	-1.2	-1.7	1.5
Crohns Disease (2017)	0.7	1.5	3.4	1.9	0.9	-0.5
Irritable Bowel Disease (IBD)	0.3	0.8	1.0	1.0	-0.9	0.8
Ulcerative Colitis (UC)	1.2	2.3	4.4	-0.3	-2.1	1.6
Major Depression (MDD)	0.9	1.1	2.4	0.9	1.5	-0.5
Reaction Time	2.9	5.5	12.6	-3.5	-0.3	1.9
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.8	-1.9	0.6	-1.7
Breast Cancer	1.5	3.7	6.8	-2.1	2.6	0.2
Ovarian Cancer	0.2	0.3	0.4	-0.7	0.5	-0.3
Prostate Cancer	1.7	2.5	5.6	-0.7	-1.1	2.4
Age at First Birth	0.3	0.5	0.9	-0.6	-0.3	1.0
Bipolar Disorder (2011)	1.1	1.1	2.4	-1.5	-0.4	0.8
Body Mass Index (BMI) (2010)	1.4	1.9	5.6	2.4	-0.2	0.0
Coronary Artery Disease (CAD)	0.4	0.4	0.9	0.6	0.3	1.0
Crohns Disease (2012)	0.7	1.2	1.9	0.8	0.9	-1.4
Mean Putamen Volume	0.6	0.7	1.6	0.3	-1.3	0.6
Fasting Glucose	0.6	0.7	1.1	0.9	0.6	1.1
HbA1C	0.2	0.2	0.5	-0.2	-0.7	0.0
HDL Cholesterol	0.1	0.1	0.4	0.2	-0.1	0.6
LDL Cholesterol	0.6	1.0	2.1	0.4	1.4	-0.9
Lupus	2.4	3.6	7.4	1.2	1.4	-2.7
Neuroticism (2016)	1.4	2.0	5.1	2.3	0.6	0.7
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.7	-0.4	0.2
Rheumatoid Arthritis	0.6	0.8	1.1	0.2	1.1	-1.1
Schizophrenia (2014)	0.5	1.1	1.7	-0.6	-1.3	1.1
Triglycerides	0.6	1.0	2.8	-0.2	1.7	-0.3
Type 2 Diabetes (T2D) (2012)	1.6	1.8	4.0	2.0	0.9	0.8
Ulcerative Colitis	2.3	3.3	4.9	-1.2	-2.2	1.9
Blood Eosinophil Count	0.1	0.6	0.9	-1.0	-0.2	-1.0
Blood Platelet Count	0.1	1.2	2.9	-0.8	1.7	-0.1
Blood Red Count	0.0	0.4	0.8	0.7	0.9	-0.3
Blood White Count	0.2	1.3	2.8	-1.1	1.7	-0.1
Heel T-Score	4.9	39.3	67.1	-3.9	-8.2	6.0
BMI	1.0	5.8	6.7	2.4	-2.2	2.6
Height	1.2	22.6	48.3	-3.8	-7.0	2.2
Waist Hip Ratio (WHR)	4.7	21.1	47.7	1.1	6.9	-3.8
Systolic Blood Pressure	1.1	5.6	15.2	-0.1	3.9	-1.2
Smoking Status	0.1	0.2	0.2	-0.4	-0.4	0.4
Allergy or Eczema	0.2	0.6	1.7	-1.3	0.3	-0.3
Cardiovascular Disease	2.0	6.6	13.5	1.6	3.7	-2.0
Hypothyroidism (self reported)	0.1	0.2	0.4	0.2	0.3	0.6
Respiratory disease	0.5	1.0	2.8	0.6	0.0	1.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.6	1.3	0.9	-0.1
Lung FEV1/FVC ratio	0.7	3.5	6.2	-2.1	2.5	0.4
Lung FVC	0.3	1.4	3.8	0.2	-2.0	0.6
Neuroticism	0.3	0.6	1.2	0.7	0.4	-1.1
Chronotype (morning person)	0.4	0.9	2.3	1.5	0.2	-0.6
Hair Pigment	0.2	6.4	12.5	1.0	3.5	-2.4
Tanning	0.1	0.8	2.2	1.5	0.2	-0.3
Hand grip strength (left)	0.9	2.5	5.8	0.1	-2.4	1.3
Number of treatments/medications taken	0.4	0.7	1.5	0.7	-0.1	1.2
Average weekly spirits intake	0.6	0.8	2.1	0.3	0.3	1.5
Sensitivity / hurt feelings	0.2	0.4	1.0	0.2	-1.0	-0.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-1.1	0.3	0.6
Hearing difficulty/problems: Yes	1.8	2.8	5.0	1.8	2.2	-0.6
Relative age of first facial hair	0.9	1.8	4.3	0.5	-2.1	-1.0
Other serious medical condition/disability diagnosed by doctor	3.4	4.4	8.5	-0.7	-2.9	2.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	-0.9	0.7	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.5	0.3	0.4
Systolic blood pressure, automated reading	0.8	2.2	5.8	-0.0	2.4	-1.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.2	-0.0	-1.5	0.3
Angina	0.2	0.3	0.7	-0.9	0.2	-0.0
Medication for hormone replacement therapy	1.3	1.4	2.2	1.2	1.5	-0.8
Vitamin and mineral supplements	1.7	2.3	3.4	1.5	1.0	-1.9
Supplements: Zinc	1.0	1.0	1.8	-1.1	-1.3	0.4
Medication: Co-codamol	0.9	1.0	1.6	1.3	-0.8	0.9
Medication: Metformin	0.2	0.3	0.8	0.0	0.5	-0.9
Diabetes (father)	0.8	0.9	2.7	1.6	0.3	-0.2
Diabetes (mother)	0.7	0.8	1.2	0.4	-1.1	1.1
Severe depression (siblings)	0.6	0.7	1.9	-1.4	0.1	0.5
Pack years adult smoking proportion	0.5	0.7	1.3	0.7	-1.1	0.6
Impedance of leg (right)	2.1	10.1	17.9	-1.7	4.2	-3.1
Leg fat-free mass (left)	2.4	12.6	27.4	0.3	-5.2	3.2
Trunk fat percentage	0.6	2.3	3.5	1.9	-0.4	1.8
Hand grip strength (right)	0.8	2.0	4.3	-0.4	-2.1	1.3
Townsend deprivation index at recruitment	3.1	4.4	8.1	0.7	2.9	-2.1
Current tobacco smoking	0.4	0.7	1.3	0.3	-0.9	1.1
Average weekly fortified wine intake	2.0	2.4	5.4	-1.2	-2.3	0.6
Maternal smoking around birth	0.4	0.6	1.0	-0.5	-0.7	1.0
Fed-up feelings	0.4	0.7	1.7	0.5	1.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	-0.7	0.2	1.2
Relative age voice broke	0.9	1.4	2.5	1.1	-0.7	-1.6
Taking other prescription medications	1.1	1.7	3.3	0.2	-1.4	1.8
Age when periods started (menarche)	1.4	3.3	7.1	0.9	1.4	-2.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.4	1.1	1.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	15.2	-0.2	-3.9	3.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.9	0.5	1.0	-0.5
Qualifications: CSEs or equivalent	0.5	0.7	1.2	-0.0	1.1	1.0
Serious illness, injury or assault to yourself	1.8	2.2	3.9	-1.6	-2.0	0.5
High blood pressure	0.8	2.1	6.1	0.5	2.5	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	-1.5	-0.1	-0.6
Multivitamins +/- minerals	1.4	1.8	4.0	-0.8	-0.8	2.0
Stomach or abdominal pain in last month	0.4	0.6	0.9	1.0	0.5	0.7
Supplements: Glucosamine	0.7	0.9	2.3	-0.3	-1.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.1	0.8	-0.6
Medication: Atenolol	1.4	1.7	4.4	-0.7	-0.4	2.1
Medication: Levothyroxine sodium	1.0	1.6	4.2	-0.8	-0.3	2.0
Sitting height	2.0	14.0	35.8	-2.2	-6.0	1.2
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	-0.0	1.0	-0.6
High blood pressure (mother)	2.1	3.0	6.6	1.3	2.6	-0.8
Body mass index (BMI)	1.0	4.4	6.1	2.2	-1.6	2.5
Impedance of leg (left)	2.3	11.3	20.2	-1.4	4.5	-3.4
Leg predicted mass (left)	2.4	12.6	27.5	0.2	-5.2	3.2
Trunk fat mass	0.8	3.4	4.6	1.6	-1.7	2.1
Waist circumference	0.3	1.2	3.3	1.8	0.0	0.6
Number of incorrect matches in round	0.4	0.6	1.7	-0.1	0.3	-1.3
Past tobacco smoking	0.3	0.6	1.7	-0.1	-0.2	1.3
Alcohol usually taken with meals	0.7	1.1	2.9	-0.0	-1.7	0.6
Nervous feelings	0.1	0.1	0.2	-0.1	0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.4	-0.0	-0.2
Hearing difficulty/problems with background noise	1.6	2.6	6.4	2.5	1.1	-0.1
Hair/balding pattern: Pattern 2	0.9	1.2	2.8	0.7	1.7	0.6
Had menopause	1.8	2.2	4.0	1.2	1.1	-2.0
Had other major operations	0.6	0.7	1.2	-1.1	-1.0	0.2
Forced vital capacity (FVC)	0.7	2.8	7.8	-0.4	-2.8	0.6
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	10.6	-0.3	-3.3	2.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.8	-0.2	0.4
Qualifications: None of the above	1.0	2.1	5.5	2.4	0.8	-0.2
Financial difficulties in last 2 years	0.5	0.7	1.8	0.2	1.3	-0.4
Mouth/teeth dental problems	0.2	0.3	0.8	0.4	-0.9	-0.2
Heart attack	3.1	3.9	4.7	1.9	2.2	-1.8
Allergy	0.1	0.3	0.6	0.8	0.4	0.5
Pain all over the body in last month	1.4	1.5	1.7	-1.2	1.3	1.2
Diabetes (self-reported)	0.5	0.7	1.7	0.3	1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	5.4	-1.4	-2.3	1.8
Medication: Ramipril	0.8	1.0	2.2	0.7	1.5	0.5
Medication: Simvastatin	0.3	0.5	0.8	0.1	-0.8	0.9
Fluid intelligence score	0.6	1.2	2.0	-1.4	0.5	-1.2
Illnesses of siblings	0.3	0.4	0.7	-0.9	-0.6	-0.4
Neuroticism score	0.1	0.1	0.3	0.4	-0.5	-0.0
Weight	1.3	6.6	11.6	1.0	-3.4	2.7
Impedance of arm (right)	0.8	3.6	9.3	-0.8	3.0	-1.0
Arm fat percentage (right)	0.9	3.6	5.2	2.3	-0.7	2.2
Trunk fat-free mass	1.6	9.4	23.3	-0.7	-4.8	2.1
Hip circumference	1.9	8.3	18.0	0.4	-4.2	2.6
Time employed in main current job	0.4	0.4	1.1	1.0	-0.4	-0.0
Alcohol intake versus 10 years previously	1.4	2.1	3.4	-1.1	-1.8	1.3
Father’s age at death	0.4	0.5	1.3	-0.0	-0.5	-1.1
Worrier / anxious feelings	0.2	0.4	0.7	0.6	-0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.5	0.5	-0.8	1.2
Falls in the last year	2.7	3.6	6.3	-1.6	-2.5	1.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	0.6	-0.6	-1.2
Number of live births	1.6	2.3	2.5	1.5	1.6	-1.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.8	-0.7	-2.2	0.8
Pulse rate	0.8	1.4	3.5	-1.9	-0.4	0.8
Happiness	0.8	1.0	1.9	0.8	1.4	-0.6
Noisy workplace	0.6	0.7	1.6	0.2	0.8	1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-0.9	-2.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.3	1.8	-0.5	1.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.8	-0.4	-1.1
Asthma	0.5	1.0	2.7	-0.2	-0.5	1.6
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	3.9	-0.4	-2.0	1.8
Medication: Cholesterol lowering	0.5	0.8	1.1	-0.5	1.1	-1.1
Depression (self-reported)	1.9	2.3	2.4	-1.5	-1.4	1.6
Medication: Lansoprazole	0.3	0.3	0.7	-0.3	0.3	0.8
Prospective memory result	0.5	0.6	0.8	0.9	0.4	-0.9
Lung cancer (father)	2.4	2.8	4.8	-0.3	-2.2	1.9
Illnesses of mother	0.5	0.7	1.4	-0.3	-1.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.5	-0.7	-2.6	1.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	-1.4	-0.5	-0.0
Impedance of arm (left)	0.5	2.2	5.6	-0.3	2.4	-1.0
Arm fat mass (right)	1.3	5.4	7.5	1.9	-2.2	2.7
Trunk predicted mass	1.7	9.7	24.3	-0.7	-4.9	2.1
Standing height	0.9	9.3	20.5	-2.5	-4.5	1.1
Length of working week for main job	3.8	4.2	8.3	-1.6	-2.9	1.4
Exposure to tobacco smoke at home	0.6	0.7	2.0	0.1	0.0	1.4
Breastfed as a baby	0.3	0.4	0.6	-0.7	-0.4	-0.8
Tense / ‘highly strung’	0.4	0.7	2.0	1.4	-0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	4.4	-1.2	-0.6	2.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.3	0.1	-0.4
Birth weight of first child	0.8	1.4	2.8	-0.9	-1.7	-0.8
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.1	0.2	-0.3
Pulse wave reflection index	0.3	0.4	1.0	0.1	1.0	0.3
Ever highly irritable/argumentative for 2 days	3.9	4.7	7.6	1.5	2.8	-2.0
Loud music exposure frequency	0.8	0.8	1.1	1.1	-0.8	0.9
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.3	-1.4	-1.2	1.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.1	-0.7	0.6	1.8
Blood clot in the leg (DVT)	0.7	0.9	2.3	0.2	-1.5	0.6
Medication: Paracetamol	0.1	0.2	0.4	-0.3	-0.6	0.3
Headache pain in last month	0.7	1.3	2.7	-1.7	-0.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.1	0.8	-1.4	0.5
Glaucoma (self-reported)	0.4	0.5	0.8	-0.6	-0.9	0.6
Gout (self-reported)	0.6	0.9	2.0	1.4	0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.8	1.1	0.6	2.0
Medication: Amlodipine	1.1	1.5	3.0	0.9	1.7	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.2	-1.1	-1.0	0.1
Birth weight	2.5	5.5	8.9	-1.8	-3.0	2.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	0.8	0.6	-0.7
High blood pressure (siblings)	0.2	0.3	0.6	0.4	0.5	0.8
Forced vital capacity (FVC), Best measure	0.9	3.2	8.2	-0.4	-2.9	1.1
Body fat percentage	0.6	2.3	3.5	1.9	-0.3	1.9
Leg fat percentage (right)	0.3	1.2	1.9	1.4	0.3	1.3
Arm fat-free mass (right)	1.9	9.7	23.4	0.0	-4.8	2.4
Exposure to tobacco smoke outside home	0.3	0.4	0.5	0.7	0.6	0.5
Comparative body size at age 10	0.1	0.4	0.6	-0.8	-0.6	0.4
Number of full brothers	0.9	1.1	3.0	0.4	-0.2	1.7
Worry too long after embarrassment	0.8	1.3	2.8	1.0	-1.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	0.7	0.1	1.4
Wheeze or whistling in the chest in last year	0.5	0.9	1.8	0.6	-0.8	1.3
Number of children fathered	0.3	0.3	0.6	0.8	0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.4	0.7	0.3	-1.9
Age at first live birth	0.4	0.7	0.8	-0.7	0.8	0.9
Pulse wave peak to peak time	0.3	0.4	1.1	1.1	0.1	0.0
Health satisfaction	0.5	0.6	1.3	1.1	0.7	-0.2
Shortness of breath walking on level ground	1.5	1.8	4.8	-0.1	-0.7	2.2
Qualifications: College or University degree	0.7	2.3	4.8	-2.2	-1.4	-0.2
Eye problems/disorders: None of the above	1.6	1.8	3.1	1.8	1.3	-0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.0	1.4	-1.2	0.5
Emphysema/chronic bronchitis	0.6	0.7	1.1	1.1	0.2	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	-1.2	0.1	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.4	0.6	0.6	-0.1
Medication: Blood pressure	0.5	1.0	2.5	-0.3	1.6	0.5
Angina (self-reported)	0.2	0.3	0.8	-0.9	0.1	0.1
Migraine (self-reported)	0.5	0.6	1.1	-0.6	-1.0	0.6
Medication: Ibuprofen	1.3	1.6	3.5	-0.4	-1.9	1.0
Medication: Allopurinol	1.1	1.4	2.6	1.2	0.4	-1.6
Medication: Omeprazole	0.8	1.0	2.0	1.4	-0.8	0.5
Medication: Seretide 50 evohaler	2.2	2.5	3.3	1.2	-1.8	1.6
Mean time to correctly identify matches	1.3	2.4	6.1	-2.5	0.3	1.0
Heart disease (mother)	0.1	0.1	0.2	0.4	0.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	-1.3	0.2	-1.1
Whole body fat mass	0.8	3.4	4.4	1.6	-1.8	2.1
Leg fat mass (right)	0.7	2.8	3.9	1.3	-1.7	2.0
Arm predicted mass (right)	1.9	9.8	23.6	-0.1	-4.9	2.4
Pulse rate, automated reading	0.3	0.9	1.1	-0.9	-0.8	1.1
Alcohol intake frequency.	0.4	0.8	2.1	-0.1	-0.6	1.4
Comparative height size at age 10	0.7	4.0	8.9	-0.3	-3.0	1.7
Number of full sisters	0.2	0.3	0.5	0.7	0.5	0.3
Suffer from ‘nerves’	0.5	0.7	1.8	-0.4	-0.5	1.3
Overall health rating	0.4	0.9	2.3	0.6	-0.4	1.5
Chest pain or discomfort	0.4	0.5	1.4	-1.2	-0.2	-0.4
Had major operations	0.7	0.8	1.0	0.8	-0.9	1.0
Age at last live birth	0.5	0.7	1.8	-0.6	1.3	0.3
Family relationship satisfaction	1.0	1.2	3.4	-1.9	0.1	-0.6
Leg pain on walking	1.2	1.5	4.1	-0.2	-0.7	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.7	1.9	0.5	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.6	1.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	0.1	0.6	-1.7
Medication: Aspirin	0.4	0.5	0.8	0.9	0.8	-0.4
Supplements: Vitamin C	2.2	2.6	3.7	-0.8	-1.9	1.9
Knee pain experienced in last month	0.6	0.9	1.5	0.8	-1.2	-0.8
Hypertension (Self-reported)	0.8	2.2	6.6	0.3	2.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.0	1.5	1.7	-0.7
Illnesses of father: Heart disease	0.7	1.0	1.7	-0.5	1.3	-1.0
Illnesses of siblings: Diabetes	0.4	0.4	0.8	0.9	0.5	-0.4
Smoking status: Previous	0.1	0.1	0.4	-0.0	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.0	-1.9	-2.2	1.1
Whole body fat-free mass	1.9	10.8	25.6	-0.3	-5.1	2.6
Leg fat-free mass (right)	2.3	12.1	27.1	0.5	-5.2	3.0
Arm fat percentage (left)	1.0	4.1	5.9	2.4	-0.9	2.3
Average weekly red wine intake	0.5	0.7	0.8	0.8	-0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	-0.9	-0.5	0.9
Mood swings	0.1	0.2	0.6	0.3	0.8	-0.2
Loneliness, isolation	0.8	1.1	2.9	-1.7	0.6	0.1
Long-standing illness, disability or infirmity	2.6	3.9	7.7	-0.8	-1.8	2.8
Ever had bowel cancer screening	0.2	0.3	0.7	0.4	-0.0	-0.8
Diabetes diagnosed by doctor	0.9	1.5	3.2	0.7	1.8	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.2	1.3	1.5	-0.9
Friendships satisfaction	0.6	0.8	1.0	0.9	1.0	-0.7
Qualifications: nursing, teaching	0.4	0.7	1.9	1.4	-0.2	-0.3
Commuting to job workplace: Walk	0.5	0.5	1.0	-1.0	-0.5	-0.5
Eye problems/disorders: Cataract	0.8	0.9	2.2	-0.4	0.6	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	-0.6	1.1	0.3
Medication for cholesterol	1.5	2.3	5.6	-1.1	-2.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.3	0.8	1.4	-1.5
Back pain experienced in last month	4.2	6.2	17.0	-0.1	-4.1	1.2
Mineral and other dietary supplements	0.3	0.4	1.0	-0.0	1.0	-0.3
Breast cancer (self-reported)	0.0	0.1	0.1	0.2	-0.3	0.2
Asthma (self-reported)	0.5	1.0	2.7	-0.1	-0.6	1.6
Osteoporosis (self-reported)	0.6	0.7	1.9	-1.4	0.1	-0.4
Osteoarthritis (self-reported)	1.5	2.0	2.4	1.2	-1.4	1.6
Medication: Aspirin	0.4	0.6	0.9	0.9	0.7	-0.5
Medication: Gliclazide	1.3	1.5	2.8	-0.4	1.7	-1.2
Illnesses of father: None of the above (group 1)	1.5	1.9	2.8	0.7	-1.7	1.6
Smoking status: Current	0.1	0.2	0.3	0.0	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	0.6	-0.5	1.0
Whole body water mass	1.9	11.0	26.0	-0.4	-5.1	2.6
Leg predicted mass (right)	2.3	12.2	27.6	0.4	-5.3	3.0
Arm fat mass (left)	1.1	4.3	5.4	1.8	-2.1	2.3
Number of self-reported non-cancer illnesses	0.8	1.4	3.3	-0.0	-0.9	1.8
Average weekly champagne plus white wine intake	0.6	0.8	2.0	-1.4	-0.7	-0.1
Miserableness	0.1	0.1	0.2	-0.3	0.2	0.5
Guilty feelings	0.3	0.5	1.0	-1.0	-0.5	-0.4
Wears glasses or contact lenses	1.2	1.4	3.8	-2.0	-0.4	-0.4
Ever taken oral contraceptive pill	0.4	0.4	1.2	-0.2	-0.3	-1.1
Hearing aid user	0.9	1.0	2.4	-1.5	0.7	-0.2
Mother’s age at death	0.3	0.4	0.8	-0.5	0.2	-0.9
Financial situation satisfaction	2.0	2.5	7.3	-0.4	2.7	-0.3
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.5	-0.3	1.3	-2.1
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.1	-0.1	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-1.4	-0.3	0.4
Medication: Blood pressure	1.3	2.5	6.4	1.0	2.5	0.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.9	-0.3	-2.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.5	0.4	-0.6
High cholesterol (Self-reported)	0.3	0.5	1.4	0.2	0.4	-1.2
Medication: Bendroflumethiazide	0.6	0.9	1.7	0.9	1.3	0.3
Medication: Paracetamol	0.2	0.3	0.3	0.5	0.5	-0.6
Medication: Lisinopril	0.8	1.1	2.8	-0.0	1.7	0.7
Medication: Atorvastatin	1.2	1.4	3.7	-0.1	0.8	-1.9
Illnesses of father: High blood pressure	1.8	2.2	2.4	-1.5	1.4	-1.5
Alcohol drinker status: Never	0.2	0.3	0.7	-0.1	0.9	-0.3
Ever smoked	0.3	0.4	1.0	0.0	-0.6	-1.0
Basal metabolic rate	1.8	10.1	23.6	-0.0	-4.9	2.6
Leg fat percentage (left)	0.4	1.5	3.1	1.8	0.3	1.1
Arm fat-free mass (left)	1.5	7.7	18.2	-0.2	-4.3	2.2
Number of operations (self-reported)	0.3	0.5	0.7	0.8	-0.6	0.7
Average weekly beer plus cider intake	0.7	1.0	2.0	0.8	1.4	-0.6
Irritability	1.3	2.2	3.2	1.3	1.3	-1.8
Risk taking	0.2	0.2	0.3	0.4	-0.6	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.7	0.3	-0.1
Fractured/broken bones in last 5 years	0.8	1.1	1.5	1.2	-1.2	0.6
Age started oral contraceptive pill	0.2	0.2	0.3	0.4	0.6	-0.3
Diastolic blood pressure, automated reading	0.8	2.5	6.6	0.2	2.6	-1.0
Ever depressed for a whole week	1.3	1.5	4.2	2.1	-0.6	-0.0
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	0.4	-0.5
Commuting to job workplace: Cycle	2.0	2.4	4.7	-2.2	-0.5	1.5
Myopia	0.9	1.4	2.2	-0.5	1.3	-1.5
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.8	-0.6	-2.6	0.5
Cholesterol lowering medication	0.1	0.2	0.5	0.7	0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	1.2	-0.2	0.2
Pain experienced in last month	3.3	5.5	10.2	0.8	3.2	-2.4
Supplements: Calcium	1.3	1.4	3.1	-0.8	-1.8	0.7
Basal cell carcinoma (self-reported)	0.9	1.1	2.5	-0.4	0.7	1.6
Heart attack/myocardial infarction (self-reported)	2.9	3.7	4.2	2.0	2.0	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.4	0.5	-1.5	0.4
Heart disease (siblings)	0.5	0.6	1.6	1.3	0.2	-0.2
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.9	0.4	0.1
Pack years of smoking	0.4	0.5	0.7	0.8	-0.8	0.5
Impedance of whole body	1.0	5.1	10.7	-1.1	3.3	-1.9
Leg fat mass (left)	0.8	3.1	4.2	1.5	-1.7	2.1
Arm predicted mass (left)	1.7	8.5	19.9	-0.3	-4.5	2.3