Hub : Genes

BAMBI

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.2380	0.0460	1.8e-07	0.137	NA	0.132	NA	0.130	1.3e-12	NA	3.5e-12	NA	5.2e-12
2	ROSMAP	Brain Pre-frontal Cortex	0.0664	0.0225	7.4e-04	0.045	0.027	0.032	0.029	0.043	1.5e-06	1.8e-04	4.6e-05	9.6e-05	2.8e-06
3	YFS	Blood	0.2704	0.0268	0.0e+00	0.249	0.248	0.310	0.310	0.310	7.8e-81	1.6e-80	6.1e-104	3.9e-104	5.7e-104
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0870	0.0370	1.3e-03	0.041	0.034	0.028	NA	0.042	2.2e-03	4.9e-03	9.6e-03	NA	1.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.7	4.4	-1.0	1.1	-0.4	-2.1
Bipolar Disorder or Schizophrenia	0.3	0.8	2.6	0.3	0.2	0.7	-1.6
Depressed Affect (Nagel 2018)	0.7	1.4	2.4	-1.5	0.8	-1.2	-1.0
Depression (Nagel 2018)	0.8	1.3	2.6	-1.6	0.9	-1.3	0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.3	0.3	2.1	-0.4	1.6
Neuroticism (Nagel 2018)	0.2	0.5	0.7	-0.9	0.6	-0.5	-0.7
Schizophrenia (2018)	0.4	0.8	1.3	1.1	-0.7	1.1	-0.4
Schizophrenia vs Biploar Disorder	1.4	1.9	2.7	-1.1	-1.6	-1.3	1.4
Worry (Nagel 2018)	0.6	1.3	3.0	-0.4	1.3	-0.5	-1.7
Alzheimer’s Disease (in mother)	0.9	1.0	2.4	-0.1	-1.6	0.2	1.2
Alzheimer’s Disease (in father)	1.1	1.2	2.8	0.8	1.7	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.8	0.1	-1.4	-0.2	0.3
Crohns Disease (2017)	0.2	0.5	1.7	-0.5	0.1	0.3	1.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.1	0.0	0.4	0.7
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.4	-0.2	-0.2	-0.1
Major Depression (MDD)	1.2	1.5	2.4	-1.4	1.1	-0.8	-1.5
Reaction Time	0.4	0.8	1.3	-0.9	-0.2	-1.2	1.1
Verbal and Numeric Reasoning (VNR)	0.8	1.8	2.6	1.4	1.6	0.6	1.5
Breast Cancer	0.4	0.8	1.5	0.6	-1.2	0.9	0.8
Ovarian Cancer	0.4	0.5	1.4	-0.4	1.2	-0.5	-0.4
Prostate Cancer	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.2
Age at First Birth	1.0	1.5	2.5	0.7	-0.7	1.5	1.6
Bipolar Disorder (2011)	2.1	2.1	6.3	-0.6	1.2	-0.5	-2.5
Body Mass Index (BMI) (2010)	0.7	1.0	3.2	-0.4	0.3	-1.8	0.7
Coronary Artery Disease (CAD)	0.9	1.0	2.1	-0.5	1.3	-0.4	-1.4
Crohns Disease (2012)	0.5	0.8	1.8	-0.3	0.0	1.2	1.3
Mean Putamen Volume	0.8	0.9	3.2	-0.7	-0.2	0.3	-1.8
Fasting Glucose	0.1	0.2	0.4	0.4	0.3	-0.1	-0.7
HbA1C	0.1	0.1	0.3	-0.5	0.4	-0.4	0.2
HDL Cholesterol	0.5	0.8	1.5	1.2	-0.8	0.5	-1.0
LDL Cholesterol	0.9	1.5	3.1	1.2	0.7	1.8	-1.0
Lupus	0.7	1.0	1.5	1.0	-0.6	1.2	1.2
Neuroticism (2016)	0.5	0.8	2.3	1.5	-0.0	0.9	-0.4
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.1	0.1	0.8	-0.4
Rheumatoid Arthritis	0.4	0.6	1.5	-0.7	0.6	-1.2	0.1
Schizophrenia (2014)	0.1	0.2	0.6	0.1	-0.8	0.4	-0.3
Triglycerides	1.3	2.1	3.5	1.2	1.8	1.9	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.3	-0.2	0.4	0.3
Ulcerative Colitis	0.5	0.7	2.0	1.4	-0.4	0.9	0.2
Blood Eosinophil Count	3.2	24.6	90.1	0.0	-9.5	1.4	2.5
Blood Platelet Count	0.4	4.1	9.0	-0.6	-3.0	-0.0	2.6
Blood Red Count	0.2	1.9	4.1	-1.1	1.4	-0.3	-2.0
Blood White Count	2.3	16.9	57.6	-0.5	-7.6	-0.7	3.0
Heel T-Score	1.4	11.1	33.2	-1.1	3.1	-5.8	-0.4
BMI	0.5	2.9	8.3	-1.3	0.7	-2.9	-1.1
Height	0.6	10.9	38.6	-0.7	6.2	-1.8	-1.2
Waist Hip Ratio (WHR)	0.6	2.7	3.8	1.6	1.1	1.8	-1.9
Systolic Blood Pressure	0.6	2.8	4.6	1.6	-2.1	1.5	-1.4
Smoking Status	0.5	1.2	2.8	-0.2	1.7	-1.2	-0.8
Allergy or Eczema	0.3	0.9	1.6	0.8	-0.4	1.1	1.3
Cardiovascular Disease	0.9	2.8	11.0	0.3	-0.1	0.5	-3.3
Hypothyroidism (self reported)	0.4	1.0	1.5	-0.9	-1.2	-0.8	1.0
Respiratory disease	0.4	0.8	2.3	0.1	-1.5	-0.1	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.3	-0.2	1.1	-0.3	0.7
Lung FEV1/FVC ratio	1.5	7.5	15.4	1.8	3.9	0.9	-3.3
Lung FVC	0.4	1.8	4.6	-1.5	2.2	0.4	-0.4
Neuroticism	0.2	0.4	1.0	-0.7	-0.1	-0.4	-1.0
Chronotype (morning person)	0.8	1.9	5.6	1.0	2.4	0.9	-0.1
Hair Pigment	0.1	2.0	8.0	-0.2	-2.8	-0.1	-0.4
Tanning	0.2	1.9	6.9	-0.7	2.6	0.3	-0.4
Hand grip strength (left)	1.1	3.0	6.0	-2.4	1.1	-2.1	-0.5
Number of treatments/medications taken	1.9	3.4	7.3	2.0	0.3	1.4	-2.7
Average weekly spirits intake	0.4	0.4	1.4	-0.2	0.2	1.2	0.5
Sensitivity / hurt feelings	1.0	1.8	4.1	0.4	-2.0	0.9	1.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.6	0.7	-0.6	-0.4
Hearing difficulty/problems: Yes	1.3	1.9	6.8	-0.6	2.6	-0.7	0.4
Relative age of first facial hair	0.9	1.9	6.4	0.3	-2.5	-0.0	1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.9	-0.1	-0.2	0.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.6	1.3	-1.9	0.4	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.3	-0.1	-0.8	-0.3
Systolic blood pressure, automated reading	1.0	3.0	6.4	1.8	-1.1	1.2	-2.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.0	0.2	-1.0	0.4	0.5
Angina	1.8	2.3	8.2	0.0	0.9	-0.3	-2.9
Medication for hormone replacement therapy	0.8	0.9	3.1	-0.7	-0.2	-1.8	-0.4
Vitamin and mineral supplements	0.1	0.1	0.2	-0.5	0.1	-0.0	-0.2
Supplements: Zinc	0.5	0.6	1.3	-0.1	-1.1	0.2	-0.9
Medication: Co-codamol	2.8	3.2	8.1	2.9	0.6	2.1	-0.4
Medication: Metformin	0.7	0.9	2.6	1.0	0.1	1.6	0.2
Diabetes (father)	0.5	0.7	1.2	1.0	-0.1	0.7	1.1
Diabetes (mother)	0.8	1.0	2.5	-1.2	0.3	-1.6	-0.1
Severe depression (siblings)	2.0	2.3	8.4	-0.0	2.9	0.6	-0.6
Pack years adult smoking proportion	0.1	0.1	0.3	-0.0	0.2	0.1	-0.5
Impedance of leg (right)	1.4	6.7	17.4	2.2	-2.0	4.2	-0.7
Leg fat-free mass (left)	1.4	7.2	15.3	-2.3	2.9	-3.9	-0.4
Trunk fat percentage	0.1	0.4	0.6	0.6	-0.6	-0.4	-0.8
Hand grip strength (right)	1.1	2.9	4.3	-1.8	2.1	-1.8	-1.0
Townsend deprivation index at recruitment	0.6	0.9	2.8	0.3	0.2	0.8	-1.7
Current tobacco smoking	0.2	0.3	0.7	-0.0	0.9	-0.5	-0.4
Average weekly fortified wine intake	1.2	1.4	3.1	0.0	-1.8	1.3	0.9
Maternal smoking around birth	0.6	0.9	1.2	-1.0	0.5	-1.1	-1.1
Fed-up feelings	0.5	1.0	1.6	-1.1	0.6	-0.8	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.6	1.0	-0.3	0.5
Relative age voice broke	0.1	0.1	0.5	-0.7	0.1	-0.1	0.1
Taking other prescription medications	1.1	1.7	6.0	0.2	-0.6	-0.5	-2.5
Age when periods started (menarche)	0.3	0.8	1.5	0.1	-1.2	1.2	0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.3	1.5	-1.3	1.0	0.8
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	12.6	-0.2	3.6	-2.8	-0.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	6.6	-0.4	-0.1	-0.6	-2.6
Qualifications: CSEs or equivalent	0.3	0.3	0.6	0.4	0.8	-0.1	-0.8
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.2	-0.5	0.9	-0.2
High blood pressure	1.5	4.1	13.2	1.0	-0.7	1.3	-3.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.8	0.8	0.2	1.4	0.5
Multivitamins +/- minerals	0.9	1.1	2.5	1.6	-0.8	1.1	0.1
Stomach or abdominal pain in last month	0.3	0.4	1.3	-0.1	0.2	0.4	-1.2
Supplements: Glucosamine	0.9	1.1	2.1	1.0	-0.2	1.2	-1.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.5	0.6	-2.4	0.1	0.5
Medication: Atenolol	0.4	0.5	1.9	-0.2	0.0	0.4	-1.4
Medication: Levothyroxine sodium	0.4	0.6	0.9	-0.8	-1.0	-0.9	0.3
Sitting height	1.7	12.3	42.9	-1.1	6.5	-1.9	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.4	-1.1	0.2	0.7
High blood pressure (mother)	0.8	1.1	3.9	-0.2	0.5	0.3	-2.0
Body mass index (BMI)	0.3	1.4	4.0	-0.4	-0.1	-2.0	-1.2
Impedance of leg (left)	1.4	6.6	17.1	2.3	-2.0	4.1	-0.2
Leg predicted mass (left)	1.4	7.4	15.4	-2.3	2.9	-3.9	-0.5
Trunk fat mass	0.2	0.6	1.2	0.0	0.7	-1.1	-0.9
Waist circumference	0.3	1.3	3.7	0.5	0.5	-0.9	-1.9
Number of incorrect matches in round	1.6	2.7	5.6	-1.8	-1.4	-2.4	0.3
Past tobacco smoking	1.2	2.2	4.5	0.9	-2.1	1.2	1.4
Alcohol usually taken with meals	0.7	1.1	3.1	-0.3	-0.6	-0.9	1.8
Nervous feelings	0.2	0.3	0.6	0.2	0.8	-0.7	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.0	0.9	-0.4	0.2
Hearing difficulty/problems with background noise	0.3	0.4	1.2	0.1	1.1	0.2	0.7
Hair/balding pattern: Pattern 2	3.5	4.5	9.9	-3.1	-1.5	-2.3	-0.8
Had menopause	0.7	0.9	2.3	1.0	-1.5	0.5	-0.2
Had other major operations	0.9	1.1	2.4	-0.5	0.6	-1.6	-1.2
Forced vital capacity (FVC)	1.3	4.9	9.6	-2.5	3.1	-1.8	0.6
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.2	14.5	-0.4	3.8	-3.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.8	-0.3	0.2	0.5
Qualifications: None of the above	1.3	2.8	6.2	-1.8	-0.7	-1.1	-2.5
Financial difficulties in last 2 years	0.4	0.5	1.0	1.0	-0.5	0.8	0.2
Mouth/teeth dental problems	0.4	0.5	1.6	-0.6	0.4	-0.2	1.3
Heart attack	0.8	1.0	2.0	0.8	-0.3	1.4	-1.1
Allergy	0.1	0.2	0.7	0.1	0.8	-0.4	0.2
Pain all over the body in last month	2.0	2.1	2.9	-0.5	1.7	-1.5	-1.7
Diabetes (self-reported)	0.9	1.3	3.8	2.0	0.4	1.1	0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.4	-0.1	-1.3	0.9	1.6
Medication: Ramipril	0.3	0.4	0.9	-0.3	0.1	-0.6	1.0
Medication: Simvastatin	1.4	2.0	4.2	1.4	0.3	2.1	-1.3
Fluid intelligence score	0.8	1.7	4.7	1.2	2.2	0.4	0.7
Illnesses of siblings	2.9	4.1	15.1	-0.2	-0.6	-0.9	3.9
Neuroticism score	0.0	0.1	0.2	0.3	-0.0	-0.2	-0.5
Weight	0.6	3.2	7.1	-1.2	1.7	-2.7	-1.1
Impedance of arm (right)	1.1	5.1	12.9	0.3	-3.6	1.8	2.0
Arm fat percentage (right)	0.2	0.8	2.2	-0.2	-0.9	-1.5	-0.5
Trunk fat-free mass	1.5	8.4	16.2	-2.3	4.0	-3.4	-0.8
Hip circumference	0.3	1.4	4.1	-0.8	-0.1	-2.0	-0.9
Time employed in main current job	0.4	0.4	0.7	-0.4	-0.8	0.8	0.6
Alcohol intake versus 10 years previously	2.1	3.2	4.5	1.9	1.7	2.1	-1.3
Father’s age at death	0.2	0.3	0.6	-0.5	0.8	-0.6	0.2
Worrier / anxious feelings	0.2	0.4	0.7	-0.3	-0.0	-0.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.8	-0.0	0.2	-0.1	-0.9
Falls in the last year	0.9	1.2	2.2	1.4	0.2	1.5	-0.8
Hair/balding pattern: Pattern 3	1.7	2.5	4.5	1.8	0.5	2.1	1.5
Number of live births	2.3	3.2	10.2	-0.2	1.0	-1.3	-3.2
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	14.5	-1.2	3.8	-1.1	-0.6
Pulse rate	0.4	0.7	2.6	-0.0	-0.1	-0.4	-1.6
Happiness	0.9	1.1	2.8	-0.9	-0.8	-1.7	0.5
Noisy workplace	0.3	0.4	1.2	-0.5	-1.1	-0.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.1	0.3	0.2	0.9	2.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.2	0.2	1.1	-0.5	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.5	0.1	0.1	-0.8
Asthma	0.7	1.3	3.7	-0.5	-1.9	-0.5	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	-0.8	0.2	-1.1	-0.5
Medication: Cholesterol lowering	2.9	4.5	6.6	1.7	2.6	2.4	-1.8
Depression (self-reported)	0.8	1.0	1.3	-1.1	1.0	-1.0	-0.8
Medication: Lansoprazole	1.0	1.2	2.3	1.5	0.2	1.0	-1.1
Prospective memory result	0.7	0.9	2.7	0.5	-0.8	1.6	-0.2
Lung cancer (father)	0.6	0.7	1.7	-1.0	-0.1	0.3	-1.3
Illnesses of mother	0.5	0.6	2.3	0.4	0.3	-0.0	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	9.0	-1.5	3.0	-0.3	-0.6
Pulse wave Arterial Stiffness index	0.7	0.8	2.2	-0.3	0.1	-0.9	-1.5
Impedance of arm (left)	0.9	4.4	9.5	0.3	-3.1	1.7	2.2
Arm fat mass (right)	0.3	1.4	4.8	-0.6	0.2	-2.2	-0.7
Trunk predicted mass	1.5	8.8	16.6	-2.4	4.1	-3.5	-0.8
Standing height	0.6	5.7	16.5	-1.9	4.1	-1.7	0.3
Length of working week for main job	0.8	0.9	1.4	-1.2	-0.2	-1.2	-0.8
Exposure to tobacco smoke at home	1.2	1.3	3.8	0.5	-2.0	1.0	-0.5
Breastfed as a baby	0.7	0.8	3.0	0.2	1.7	-0.3	-0.5
Tense / ‘highly strung’	0.4	0.6	1.5	0.8	0.5	0.3	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.6	-0.7	0.8	-1.6	0.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	-0.4	0.4	0.8	1.2
Birth weight of first child	0.5	0.8	1.8	-1.2	-0.2	-1.3	0.5
Peak expiratory flow (PEF)	3.2	7.3	16.0	-1.8	4.0	-2.5	-2.0
Pulse wave reflection index	0.2	0.3	0.5	0.3	0.6	0.3	-0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.2	-1.2	0.8	0.4
Loud music exposure frequency	1.6	1.7	4.7	0.7	1.3	-0.2	-2.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.4	0.3	2.1	0.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	0.6	-0.0	0.6	-1.1
Blood clot in the leg (DVT)	0.5	0.7	2.0	-0.3	0.6	0.5	-1.4
Medication: Paracetamol	0.5	0.9	2.3	-0.9	1.5	-0.6	0.2
Headache pain in last month	0.3	0.5	1.4	0.8	0.1	1.2	0.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	6.3	-1.8	-1.4	-2.5	1.1
Glaucoma (self-reported)	0.6	0.7	1.3	-0.9	-1.1	-0.6	0.7
Gout (self-reported)	0.1	0.2	0.3	0.1	-0.0	-0.6	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.5	-0.8	-0.6	-0.2
Medication: Amlodipine	0.2	0.3	0.6	-0.1	0.8	0.7	0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.8	3.0	0.2	-1.7	0.2	-0.5
Birth weight	0.4	0.9	1.8	-0.3	-1.4	-0.6	1.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.4	-1.2	-1.2	-0.9	0.1
High blood pressure (siblings)	1.9	2.7	6.7	1.4	0.6	1.4	-2.6
Forced vital capacity (FVC), Best measure	1.1	3.9	7.4	-2.7	2.5	-1.3	0.4
Body fat percentage	0.1	0.5	1.1	0.7	-0.7	-0.3	-1.0
Leg fat percentage (right)	0.4	1.5	3.3	1.1	-1.1	0.4	-1.8
Arm fat-free mass (right)	1.6	8.1	19.6	-1.4	4.4	-2.8	-1.7
Exposure to tobacco smoke outside home	0.7	0.9	2.3	-0.5	-1.0	-1.5	0.1
Comparative body size at age 10	0.7	1.8	2.9	-1.7	-1.2	-1.7	0.3
Number of full brothers	1.0	1.2	1.6	-1.0	1.3	-1.0	-1.1
Worry too long after embarrassment	0.1	0.2	0.4	0.4	-0.7	-0.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.1	-1.1	0.6	-0.9	0.1
Wheeze or whistling in the chest in last year	1.0	1.8	2.9	-1.7	-1.1	-1.2	-1.3
Number of children fathered	2.3	2.6	4.4	-1.7	1.7	-2.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.4	-0.2	-0.8	-0.1	1.2
Age at first live birth	2.0	3.5	9.5	0.8	0.1	1.9	3.1
Pulse wave peak to peak time	0.8	0.9	2.3	0.3	0.4	1.1	1.5
Health satisfaction	0.5	0.7	1.0	-0.6	-0.7	-1.0	-1.0
Shortness of breath walking on level ground	0.2	0.3	0.5	0.5	-0.5	0.7	-0.2
Qualifications: College or University degree	1.1	3.4	11.6	-0.8	-1.1	-0.4	3.4
Eye problems/disorders: None of the above	1.6	1.8	4.7	-0.7	2.2	-0.8	-1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-1.0	-0.5	-0.8	-0.7
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	-0.4	-0.2	0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	1.9	0.1	-1.2	0.3	1.4
Neck or shoulder pain in last month	1.9	2.7	5.0	1.1	2.2	1.0	-1.9
Medication: Blood pressure	1.1	2.0	5.0	1.2	1.0	2.2	-0.7
Angina (self-reported)	1.4	1.8	6.5	-0.2	0.8	-0.4	-2.5
Migraine (self-reported)	1.0	1.2	2.2	-1.5	-1.4	-0.8	0.0
Medication: Ibuprofen	0.3	0.3	0.9	-0.5	0.3	-0.9	-0.3
Medication: Allopurinol	0.5	0.6	1.9	0.2	-0.7	-0.2	-1.4
Medication: Omeprazole	0.3	0.4	0.8	0.1	-0.4	-0.6	-0.9
Medication: Seretide 50 evohaler	2.1	2.4	4.9	1.9	-1.0	2.2	-0.4
Mean time to correctly identify matches	0.4	0.7	1.6	0.4	-1.1	0.2	1.3
Heart disease (mother)	1.2	1.5	5.2	0.0	0.5	-0.6	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.3	0.0	-0.2	0.1	-1.1
Whole body fat mass	0.2	0.7	1.3	0.0	0.6	-1.1	-1.1
Leg fat mass (right)	0.2	0.9	2.8	0.3	0.3	-0.8	-1.7
Arm predicted mass (right)	1.7	8.7	22.8	-1.3	4.8	-2.4	-2.1
Pulse rate, automated reading	0.1	0.2	0.5	0.5	0.3	0.4	-0.7
Alcohol intake frequency.	0.6	1.3	3.7	0.7	1.9	0.3	-1.0
Comparative height size at age 10	0.5	2.7	5.2	-1.7	2.3	-1.4	0.9
Number of full sisters	1.0	1.2	1.7	1.1	0.9	1.3	-1.1
Suffer from ‘nerves’	1.3	2.1	3.1	1.4	1.8	0.8	-1.6
Overall health rating	0.5	1.0	2.1	-0.1	-1.2	-0.7	-1.4
Chest pain or discomfort	1.1	1.6	1.7	-1.1	1.2	-1.3	-1.3
Had major operations	4.0	4.7	8.1	-1.6	2.6	-1.2	-2.9
Age at last live birth	1.0	1.4	2.8	1.1	-0.4	1.7	1.2
Family relationship satisfaction	0.9	1.1	1.7	0.8	-0.6	-1.3	1.3
Leg pain on walking	1.0	1.2	3.2	1.8	0.4	0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.6	0.5	0.0	-1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.5	0.5	1.6	-0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	1.3	-0.9	1.1	-0.0
Medication: Aspirin	1.2	1.6	3.6	1.3	0.5	1.0	-1.9
Supplements: Vitamin C	0.6	0.7	1.8	-0.2	-0.5	-1.4	-0.7
Knee pain experienced in last month	0.7	1.0	1.9	-0.6	-1.0	-0.9	1.4
Hypertension (Self-reported)	1.0	2.9	8.9	1.0	-0.5	1.2	-3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	-0.3	1.2	-0.8	-0.2
Illnesses of father: Heart disease	3.0	4.2	10.7	1.6	3.3	0.3	-1.9
Illnesses of siblings: Diabetes	1.5	1.8	5.7	-0.3	-0.1	1.2	-2.4
Smoking status: Previous	1.3	1.9	4.8	-0.2	2.2	-0.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.4	-1.2	1.1	-0.6	-0.2
Whole body fat-free mass	1.5	8.6	14.6	-2.3	3.8	-3.7	-0.8
Leg fat-free mass (right)	1.5	7.9	16.2	-2.5	3.0	-4.0	-0.1
Arm fat percentage (left)	0.2	0.8	2.4	-0.3	-0.7	-1.5	-0.4
Average weekly red wine intake	0.7	1.0	2.8	-0.5	0.3	-0.9	1.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	0.4	-1.3	0.7	0.5
Mood swings	0.5	0.9	1.4	-1.2	-0.8	-1.2	0.3
Loneliness, isolation	0.2	0.3	0.5	0.7	0.7	0.3	-0.3
Long-standing illness, disability or infirmity	0.2	0.4	0.9	-0.6	-0.9	-0.4	-0.1
Ever had bowel cancer screening	4.0	4.7	7.7	2.4	2.8	2.0	-1.2
Diabetes diagnosed by doctor	0.3	0.5	1.4	1.2	0.5	0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.0	-0.0	-2.0	0.2	-0.4
Friendships satisfaction	0.6	0.7	1.5	1.2	0.3	1.1	-0.3
Qualifications: nursing, teaching	0.6	1.0	2.0	-0.0	-1.4	-0.1	1.4
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.2	0.8	-0.0	-0.4
Eye problems/disorders: Cataract	2.7	3.1	6.8	2.6	-1.5	1.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.8	0.4	1.7	-0.2	0.1
Medication for cholesterol	0.5	0.8	2.6	-0.5	0.5	0.4	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	-0.6	0.8	-0.8	1.1
Back pain experienced in last month	0.6	0.8	1.9	1.4	-0.3	0.7	-0.9
Mineral and other dietary supplements	2.1	2.8	5.8	-2.4	-1.4	-1.3	1.4
Breast cancer (self-reported)	0.7	0.9	2.1	0.3	-1.0	-0.4	-1.4
Asthma (self-reported)	0.6	1.2	2.9	-0.4	-1.7	-0.3	-1.3
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.5	-0.7	0.1	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.8	-0.5	0.4	0.3
Medication: Aspirin	1.5	2.0	4.5	1.2	0.4	1.3	-2.1
Medication: Gliclazide	1.7	2.0	3.3	-1.8	-0.7	-1.8	-0.9
Illnesses of father: None of the above (group 1)	4.6	5.7	15.8	-1.2	-4.0	-0.2	2.3
Smoking status: Current	0.2	0.3	0.7	-0.1	0.9	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.4	-1.5	1.9	0.1	-0.8
Whole body water mass	1.5	8.7	15.1	-2.3	3.9	-3.7	-0.9
Leg predicted mass (right)	1.5	7.8	15.8	-2.4	3.1	-4.0	-0.0
Arm fat mass (left)	0.4	1.5	4.8	-0.6	0.4	-2.2	-0.8
Number of self-reported non-cancer illnesses	0.6	1.1	1.8	-0.9	-1.2	-0.6	-1.4
Average weekly champagne plus white wine intake	1.4	1.9	2.8	1.3	-1.5	1.7	0.8
Miserableness	0.9	1.5	2.5	1.1	1.5	0.2	-1.6
Guilty feelings	0.1	0.2	0.2	0.4	0.5	-0.4	0.3
Wears glasses or contact lenses	1.6	1.8	4.0	0.5	-1.1	1.4	2.0
Ever taken oral contraceptive pill	1.1	1.2	3.7	0.5	1.9	0.1	1.0
Hearing aid user	0.3	0.3	1.0	-0.4	0.4	-0.1	1.0
Mother’s age at death	0.1	0.1	0.2	0.2	0.3	0.5	0.4
Financial situation satisfaction	0.5	0.6	1.6	0.8	-1.3	-0.1	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	0.7	-0.7	1.2	0.5
Commuting to job workplace: Public transport	2.7	3.2	8.5	-1.6	-2.9	-0.2	1.4
Eye problems/disorders: Glaucoma	1.6	1.9	2.2	-1.5	-1.5	-1.4	1.1
Medication: Blood pressure	0.7	1.4	4.0	0.0	-1.2	-0.5	-2.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-0.8	0.8	-0.5	-1.3
Supplements: Fish oil (including cod liver oil)	1.2	1.6	5.5	2.3	0.2	0.3	0.9
High cholesterol (Self-reported)	2.3	4.0	7.5	1.8	1.0	2.7	-2.0
Medication: Bendroflumethiazide	0.8	1.3	2.2	1.4	-0.8	0.6	-1.5
Medication: Paracetamol	0.3	0.5	1.5	0.1	0.6	0.2	1.2
Medication: Lisinopril	2.6	3.3	4.7	1.7	-2.0	1.4	-2.2
Medication: Atorvastatin	1.7	2.1	5.5	0.8	1.3	0.6	-2.4
Illnesses of father: High blood pressure	0.8	1.0	2.3	0.3	1.1	-0.7	-1.5
Alcohol drinker status: Never	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.3
Ever smoked	1.6	2.7	7.2	-1.0	2.7	-1.4	-0.9
Basal metabolic rate	1.3	7.2	12.5	-2.1	3.4	-3.5	-0.9
Leg fat percentage (left)	0.3	1.1	2.1	1.0	-1.1	0.3	-1.5
Arm fat-free mass (left)	1.3	6.8	13.4	-1.5	3.7	-2.9	-1.8
Number of operations (self-reported)	0.9	1.3	3.4	-0.8	0.6	-1.0	-1.8
Average weekly beer plus cider intake	0.4	0.5	1.9	0.2	0.2	-0.2	-1.4
Irritability	0.1	0.2	0.3	-0.5	-0.4	-0.1	-0.5
Risk taking	0.3	0.5	1.4	0.5	-0.4	0.4	-1.2
Ever had prostate specific antigen (PSA) test	1.7	1.9	5.0	1.0	2.2	1.0	0.9
Fractured/broken bones in last 5 years	0.5	0.7	1.6	-0.9	-1.3	0.5	0.2
Age started oral contraceptive pill	2.5	3.1	3.8	1.7	-2.0	1.9	1.4
Diastolic blood pressure, automated reading	1.4	4.2	16.6	0.4	0.4	0.2	-4.1
Ever depressed for a whole week	0.7	0.9	1.6	1.3	-1.1	-0.0	0.8
Unable to work because of sickness or disability	0.2	0.2	0.3	-0.5	-0.4	0.4	0.6
Commuting to job workplace: Cycle	1.7	2.0	3.6	-1.5	0.8	-1.9	-1.2
Myopia	1.1	1.5	2.2	1.3	-1.0	1.1	1.5
Vascular/heart problems diagnosed by doctor	1.6	4.4	13.6	-1.3	0.7	-1.3	3.7
Cholesterol lowering medication	0.8	1.2	3.3	0.9	0.4	0.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.6	-0.5	-0.7	-1.0
Pain experienced in last month	0.7	1.2	3.6	-0.6	-0.4	-0.9	1.9
Supplements: Calcium	0.5	0.6	1.0	1.0	-0.1	0.9	-0.7
Basal cell carcinoma (self-reported)	0.9	1.1	1.8	0.6	1.4	1.4	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	0.7	-0.1	1.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.2	0.2	0.7	-0.9
Heart disease (siblings)	1.4	1.7	3.8	-1.1	0.6	-1.1	-1.9
Alcohol drinker status: Previous	1.6	1.8	4.9	-0.9	2.2	-0.7	-0.9
Pack years of smoking	0.1	0.2	0.4	0.4	0.1	0.6	-0.4
Impedance of whole body	0.9	4.4	9.7	1.5	-2.3	3.1	0.6
Leg fat mass (left)	0.2	0.6	1.9	0.4	0.1	-0.8	-1.4
Arm predicted mass (left)	1.5	7.5	13.9	-1.7	3.7	-3.1	-1.9