Hub : Genes

BAMBI

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Whole Blood 0.2380 0.0460 1.8e-07 0.137 NA 0.132 NA 0.130 1.3e-12 NA 3.5e-12 NA 5.2e-12
2 ROSMAP Brain Pre-frontal Cortex 0.0664 0.0225 7.4e-04 0.045 0.027 0.032 0.029 0.043 1.5e-06 1.8e-04 4.6e-05 9.6e-05 2.8e-06
3 YFS Blood 0.2704 0.0268 0.0e+00 0.249 0.248 0.310 0.310 0.310 7.8e-81 1.6e-80 6.1e-104 3.9e-104 5.7e-104
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.0870 0.0370 1.3e-03 0.041 0.034 0.028 NA 0.042 2.2e-03 4.9e-03 9.6e-03 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.1 1.7 4.4 -1.0 1.1 -0.4 -2.1
Bipolar Disorder or Schizophrenia 0.3 0.8 2.6 0.3 0.2 0.7 -1.6
Depressed Affect (Nagel 2018) 0.7 1.4 2.4 -1.5 0.8 -1.2 -1.0
Depression (Nagel 2018) 0.8 1.3 2.6 -1.6 0.9 -1.3 0.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 4.3 0.3 2.1 -0.4 1.6
Neuroticism (Nagel 2018) 0.2 0.5 0.7 -0.9 0.6 -0.5 -0.7
Schizophrenia (2018) 0.4 0.8 1.3 1.1 -0.7 1.1 -0.4
Schizophrenia vs Biploar Disorder 1.4 1.9 2.7 -1.1 -1.6 -1.3 1.4
Worry (Nagel 2018) 0.6 1.3 3.0 -0.4 1.3 -0.5 -1.7
Alzheimer’s Disease (in mother) 0.9 1.0 2.4 -0.1 -1.6 0.2 1.2
Alzheimer’s Disease (in father) 1.1 1.2 2.8 0.8 1.7 0.3 -1.1
Alzheimer’s Disease (including proxy) 0.3 0.5 1.8 0.1 -1.4 -0.2 0.3
Crohns Disease (2017) 0.2 0.5 1.7 -0.5 0.1 0.3 1.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 0.1 0.0 0.4 0.7
Ulcerative Colitis (UC) 0.0 0.1 0.2 0.4 -0.2 -0.2 -0.1
Major Depression (MDD) 1.2 1.5 2.4 -1.4 1.1 -0.8 -1.5
Reaction Time 0.4 0.8 1.3 -0.9 -0.2 -1.2 1.1
Verbal and Numeric Reasoning (VNR) 0.8 1.8 2.6 1.4 1.6 0.6 1.5
Breast Cancer 0.4 0.8 1.5 0.6 -1.2 0.9 0.8
Ovarian Cancer 0.4 0.5 1.4 -0.4 1.2 -0.5 -0.4
Prostate Cancer 0.0 0.1 0.1 -0.3 -0.3 -0.1 -0.2
Age at First Birth 1.0 1.5 2.5 0.7 -0.7 1.5 1.6
Bipolar Disorder (2011) 2.1 2.1 6.3 -0.6 1.2 -0.5 -2.5
Body Mass Index (BMI) (2010) 0.7 1.0 3.2 -0.4 0.3 -1.8 0.7
Coronary Artery Disease (CAD) 0.9 1.0 2.1 -0.5 1.3 -0.4 -1.4
Crohns Disease (2012) 0.5 0.8 1.8 -0.3 0.0 1.2 1.3
Mean Putamen Volume 0.8 0.9 3.2 -0.7 -0.2 0.3 -1.8
Fasting Glucose 0.1 0.2 0.4 0.4 0.3 -0.1 -0.7
HbA1C 0.1 0.1 0.3 -0.5 0.4 -0.4 0.2
HDL Cholesterol 0.5 0.8 1.5 1.2 -0.8 0.5 -1.0
LDL Cholesterol 0.9 1.5 3.1 1.2 0.7 1.8 -1.0
Lupus 0.7 1.0 1.5 1.0 -0.6 1.2 1.2
Neuroticism (2016) 0.5 0.8 2.3 1.5 -0.0 0.9 -0.4
Primary Biliary Cirrhosis 0.1 0.2 0.6 0.1 0.1 0.8 -0.4
Rheumatoid Arthritis 0.4 0.6 1.5 -0.7 0.6 -1.2 0.1
Schizophrenia (2014) 0.1 0.2 0.6 0.1 -0.8 0.4 -0.3
Triglycerides 1.3 2.1 3.5 1.2 1.8 1.9 -0.4
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.3 -0.2 0.4 0.3
Ulcerative Colitis 0.5 0.7 2.0 1.4 -0.4 0.9 0.2
Blood Eosinophil Count 3.2 24.6 90.1 0.0 -9.5 1.4 2.5
Blood Platelet Count 0.4 4.1 9.0 -0.6 -3.0 -0.0 2.6
Blood Red Count 0.2 1.9 4.1 -1.1 1.4 -0.3 -2.0
Blood White Count 2.3 16.9 57.6 -0.5 -7.6 -0.7 3.0
Heel T-Score 1.4 11.1 33.2 -1.1 3.1 -5.8 -0.4
BMI 0.5 2.9 8.3 -1.3 0.7 -2.9 -1.1
Height 0.6 10.9 38.6 -0.7 6.2 -1.8 -1.2
Waist Hip Ratio (WHR) 0.6 2.7 3.8 1.6 1.1 1.8 -1.9
Systolic Blood Pressure 0.6 2.8 4.6 1.6 -2.1 1.5 -1.4
Smoking Status 0.5 1.2 2.8 -0.2 1.7 -1.2 -0.8
Allergy or Eczema 0.3 0.9 1.6 0.8 -0.4 1.1 1.3
Cardiovascular Disease 0.9 2.8 11.0 0.3 -0.1 0.5 -3.3
Hypothyroidism (self reported) 0.4 1.0 1.5 -0.9 -1.2 -0.8 1.0
Respiratory disease 0.4 0.8 2.3 0.1 -1.5 -0.1 -1.0
Type 2 Diabetes (T2D) (2018) 0.2 0.5 1.3 -0.2 1.1 -0.3 0.7
Lung FEV1/FVC ratio 1.5 7.5 15.4 1.8 3.9 0.9 -3.3
Lung FVC 0.4 1.8 4.6 -1.5 2.2 0.4 -0.4
Neuroticism 0.2 0.4 1.0 -0.7 -0.1 -0.4 -1.0
Chronotype (morning person) 0.8 1.9 5.6 1.0 2.4 0.9 -0.1
Hair Pigment 0.1 2.0 8.0 -0.2 -2.8 -0.1 -0.4
Tanning 0.2 1.9 6.9 -0.7 2.6 0.3 -0.4
Hand grip strength (left) 1.1 3.0 6.0 -2.4 1.1 -2.1 -0.5
Number of treatments/medications taken 1.9 3.4 7.3 2.0 0.3 1.4 -2.7
Average weekly spirits intake 0.4 0.4 1.4 -0.2 0.2 1.2 0.5
Sensitivity / hurt feelings 1.0 1.8 4.1 0.4 -2.0 0.9 1.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 -0.6 0.7 -0.6 -0.4
Hearing difficulty/problems: Yes 1.3 1.9 6.8 -0.6 2.6 -0.7 0.4
Relative age of first facial hair 0.9 1.9 6.4 0.3 -2.5 -0.0 1.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.7 -0.9 -0.1 -0.2 0.0
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.6 1.3 -1.9 0.4 -0.2
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.3 -0.1 -0.8 -0.3
Systolic blood pressure, automated reading 1.0 3.0 6.4 1.8 -1.1 1.2 -2.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.0 0.2 -1.0 0.4 0.5
Angina 1.8 2.3 8.2 0.0 0.9 -0.3 -2.9
Medication for hormone replacement therapy 0.8 0.9 3.1 -0.7 -0.2 -1.8 -0.4
Vitamin and mineral supplements 0.1 0.1 0.2 -0.5 0.1 -0.0 -0.2
Supplements: Zinc 0.5 0.6 1.3 -0.1 -1.1 0.2 -0.9
Medication: Co-codamol 2.8 3.2 8.1 2.9 0.6 2.1 -0.4
Medication: Metformin 0.7 0.9 2.6 1.0 0.1 1.6 0.2
Diabetes (father) 0.5 0.7 1.2 1.0 -0.1 0.7 1.1
Diabetes (mother) 0.8 1.0 2.5 -1.2 0.3 -1.6 -0.1
Severe depression (siblings) 2.0 2.3 8.4 -0.0 2.9 0.6 -0.6
Pack years adult smoking proportion 0.1 0.1 0.3 -0.0 0.2 0.1 -0.5
Impedance of leg (right) 1.4 6.7 17.4 2.2 -2.0 4.2 -0.7
Leg fat-free mass (left) 1.4 7.2 15.3 -2.3 2.9 -3.9 -0.4
Trunk fat percentage 0.1 0.4 0.6 0.6 -0.6 -0.4 -0.8
Hand grip strength (right) 1.1 2.9 4.3 -1.8 2.1 -1.8 -1.0
Townsend deprivation index at recruitment 0.6 0.9 2.8 0.3 0.2 0.8 -1.7
Current tobacco smoking 0.2 0.3 0.7 -0.0 0.9 -0.5 -0.4
Average weekly fortified wine intake 1.2 1.4 3.1 0.0 -1.8 1.3 0.9
Maternal smoking around birth 0.6 0.9 1.2 -1.0 0.5 -1.1 -1.1
Fed-up feelings 0.5 1.0 1.6 -1.1 0.6 -0.8 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 -0.6 1.0 -0.3 0.5
Relative age voice broke 0.1 0.1 0.5 -0.7 0.1 -0.1 0.1
Taking other prescription medications 1.1 1.7 6.0 0.2 -0.6 -0.5 -2.5
Age when periods started (menarche) 0.3 0.8 1.5 0.1 -1.2 1.2 0.5
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.3 1.5 -1.3 1.0 0.8
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.2 12.6 -0.2 3.6 -2.8 -0.7
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 6.6 -0.4 -0.1 -0.6 -2.6
Qualifications: CSEs or equivalent 0.3 0.3 0.6 0.4 0.8 -0.1 -0.8
Serious illness, injury or assault to yourself 0.3 0.3 0.8 -0.2 -0.5 0.9 -0.2
High blood pressure 1.5 4.1 13.2 1.0 -0.7 1.3 -3.6
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.8 0.8 0.2 1.4 0.5
Multivitamins +/- minerals 0.9 1.1 2.5 1.6 -0.8 1.1 0.1
Stomach or abdominal pain in last month 0.3 0.4 1.3 -0.1 0.2 0.4 -1.2
Supplements: Glucosamine 0.9 1.1 2.1 1.0 -0.2 1.2 -1.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 5.5 0.6 -2.4 0.1 0.5
Medication: Atenolol 0.4 0.5 1.9 -0.2 0.0 0.4 -1.4
Medication: Levothyroxine sodium 0.4 0.6 0.9 -0.8 -1.0 -0.9 0.3
Sitting height 1.7 12.3 42.9 -1.1 6.5 -1.9 -1.1
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 0.4 -1.1 0.2 0.7
High blood pressure (mother) 0.8 1.1 3.9 -0.2 0.5 0.3 -2.0
Body mass index (BMI) 0.3 1.4 4.0 -0.4 -0.1 -2.0 -1.2
Impedance of leg (left) 1.4 6.6 17.1 2.3 -2.0 4.1 -0.2
Leg predicted mass (left) 1.4 7.4 15.4 -2.3 2.9 -3.9 -0.5
Trunk fat mass 0.2 0.6 1.2 0.0 0.7 -1.1 -0.9
Waist circumference 0.3 1.3 3.7 0.5 0.5 -0.9 -1.9
Number of incorrect matches in round 1.6 2.7 5.6 -1.8 -1.4 -2.4 0.3
Past tobacco smoking 1.2 2.2 4.5 0.9 -2.1 1.2 1.4
Alcohol usually taken with meals 0.7 1.1 3.1 -0.3 -0.6 -0.9 1.8
Nervous feelings 0.2 0.3 0.6 0.2 0.8 -0.7 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 0.0 0.9 -0.4 0.2
Hearing difficulty/problems with background noise 0.3 0.4 1.2 0.1 1.1 0.2 0.7
Hair/balding pattern: Pattern 2 3.5 4.5 9.9 -3.1 -1.5 -2.3 -0.8
Had menopause 0.7 0.9 2.3 1.0 -1.5 0.5 -0.2
Had other major operations 0.9 1.1 2.4 -0.5 0.6 -1.6 -1.2
Forced vital capacity (FVC) 1.3 4.9 9.6 -2.5 3.1 -1.8 0.6
Heel bone mineral density (BMD) T-score, automated (right) 2.7 6.2 14.5 -0.4 3.8 -3.2 -0.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.7 0.8 -0.3 0.2 0.5
Qualifications: None of the above 1.3 2.8 6.2 -1.8 -0.7 -1.1 -2.5
Financial difficulties in last 2 years 0.4 0.5 1.0 1.0 -0.5 0.8 0.2
Mouth/teeth dental problems 0.4 0.5 1.6 -0.6 0.4 -0.2 1.3
Heart attack 0.8 1.0 2.0 0.8 -0.3 1.4 -1.1
Allergy 0.1 0.2 0.7 0.1 0.8 -0.4 0.2
Pain all over the body in last month 2.0 2.1 2.9 -0.5 1.7 -1.5 -1.7
Diabetes (self-reported) 0.9 1.3 3.8 2.0 0.4 1.1 0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.4 -0.1 -1.3 0.9 1.6
Medication: Ramipril 0.3 0.4 0.9 -0.3 0.1 -0.6 1.0
Medication: Simvastatin 1.4 2.0 4.2 1.4 0.3 2.1 -1.3
Fluid intelligence score 0.8 1.7 4.7 1.2 2.2 0.4 0.7
Illnesses of siblings 2.9 4.1 15.1 -0.2 -0.6 -0.9 3.9
Neuroticism score 0.0 0.1 0.2 0.3 -0.0 -0.2 -0.5
Weight 0.6 3.2 7.1 -1.2 1.7 -2.7 -1.1
Impedance of arm (right) 1.1 5.1 12.9 0.3 -3.6 1.8 2.0
Arm fat percentage (right) 0.2 0.8 2.2 -0.2 -0.9 -1.5 -0.5
Trunk fat-free mass 1.5 8.4 16.2 -2.3 4.0 -3.4 -0.8
Hip circumference 0.3 1.4 4.1 -0.8 -0.1 -2.0 -0.9
Time employed in main current job 0.4 0.4 0.7 -0.4 -0.8 0.8 0.6
Alcohol intake versus 10 years previously 2.1 3.2 4.5 1.9 1.7 2.1 -1.3
Father’s age at death 0.2 0.3 0.6 -0.5 0.8 -0.6 0.2
Worrier / anxious feelings 0.2 0.4 0.7 -0.3 -0.0 -0.8 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.8 -0.0 0.2 -0.1 -0.9
Falls in the last year 0.9 1.2 2.2 1.4 0.2 1.5 -0.8
Hair/balding pattern: Pattern 3 1.7 2.5 4.5 1.8 0.5 2.1 1.5
Number of live births 2.3 3.2 10.2 -0.2 1.0 -1.3 -3.2
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 14.5 -1.2 3.8 -1.1 -0.6
Pulse rate 0.4 0.7 2.6 -0.0 -0.1 -0.4 -1.6
Happiness 0.9 1.1 2.8 -0.9 -0.8 -1.7 0.5
Noisy workplace 0.3 0.4 1.2 -0.5 -1.1 -0.1 -0.1
Qualifications: A levels/AS levels or equivalent 0.7 1.5 5.1 0.3 0.2 0.9 2.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.2 0.2 1.1 -0.5 -0.1
Mouth/teeth dental problems: Dentures 0.1 0.2 0.7 0.5 0.1 0.1 -0.8
Asthma 0.7 1.3 3.7 -0.5 -1.9 -0.5 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.3 -0.8 0.2 -1.1 -0.5
Medication: Cholesterol lowering 2.9 4.5 6.6 1.7 2.6 2.4 -1.8
Depression (self-reported) 0.8 1.0 1.3 -1.1 1.0 -1.0 -0.8
Medication: Lansoprazole 1.0 1.2 2.3 1.5 0.2 1.0 -1.1
Prospective memory result 0.7 0.9 2.7 0.5 -0.8 1.6 -0.2
Lung cancer (father) 0.6 0.7 1.7 -1.0 -0.1 0.3 -1.3
Illnesses of mother 0.5 0.6 2.3 0.4 0.3 -0.0 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 9.0 -1.5 3.0 -0.3 -0.6
Pulse wave Arterial Stiffness index 0.7 0.8 2.2 -0.3 0.1 -0.9 -1.5
Impedance of arm (left) 0.9 4.4 9.5 0.3 -3.1 1.7 2.2
Arm fat mass (right) 0.3 1.4 4.8 -0.6 0.2 -2.2 -0.7
Trunk predicted mass 1.5 8.8 16.6 -2.4 4.1 -3.5 -0.8
Standing height 0.6 5.7 16.5 -1.9 4.1 -1.7 0.3
Length of working week for main job 0.8 0.9 1.4 -1.2 -0.2 -1.2 -0.8
Exposure to tobacco smoke at home 1.2 1.3 3.8 0.5 -2.0 1.0 -0.5
Breastfed as a baby 0.7 0.8 3.0 0.2 1.7 -0.3 -0.5
Tense / ‘highly strung’ 0.4 0.6 1.5 0.8 0.5 0.3 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.6 -0.7 0.8 -1.6 0.3
Hair/balding pattern: Pattern 4 0.2 0.6 1.4 -0.4 0.4 0.8 1.2
Birth weight of first child 0.5 0.8 1.8 -1.2 -0.2 -1.3 0.5
Peak expiratory flow (PEF) 3.2 7.3 16.0 -1.8 4.0 -2.5 -2.0
Pulse wave reflection index 0.2 0.3 0.5 0.3 0.6 0.3 -0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.5 -0.2 -1.2 0.8 0.4
Loud music exposure frequency 1.6 1.7 4.7 0.7 1.3 -0.2 -2.2
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 4.4 0.3 2.1 0.4 0.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 0.6 -0.0 0.6 -1.1
Blood clot in the leg (DVT) 0.5 0.7 2.0 -0.3 0.6 0.5 -1.4
Medication: Paracetamol 0.5 0.9 2.3 -0.9 1.5 -0.6 0.2
Headache pain in last month 0.3 0.5 1.4 0.8 0.1 1.2 0.1
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 6.3 -1.8 -1.4 -2.5 1.1
Glaucoma (self-reported) 0.6 0.7 1.3 -0.9 -1.1 -0.6 0.7
Gout (self-reported) 0.1 0.2 0.3 0.1 -0.0 -0.6 -0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 -0.5 -0.8 -0.6 -0.2
Medication: Amlodipine 0.2 0.3 0.6 -0.1 0.8 0.7 0.2
Medication: Ventolin 100micrograms inhaler 0.7 0.8 3.0 0.2 -1.7 0.2 -0.5
Birth weight 0.4 0.9 1.8 -0.3 -1.4 -0.6 1.2
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.4 -1.2 -1.2 -0.9 0.1
High blood pressure (siblings) 1.9 2.7 6.7 1.4 0.6 1.4 -2.6
Forced vital capacity (FVC), Best measure 1.1 3.9 7.4 -2.7 2.5 -1.3 0.4
Body fat percentage 0.1 0.5 1.1 0.7 -0.7 -0.3 -1.0
Leg fat percentage (right) 0.4 1.5 3.3 1.1 -1.1 0.4 -1.8
Arm fat-free mass (right) 1.6 8.1 19.6 -1.4 4.4 -2.8 -1.7
Exposure to tobacco smoke outside home 0.7 0.9 2.3 -0.5 -1.0 -1.5 0.1
Comparative body size at age 10 0.7 1.8 2.9 -1.7 -1.2 -1.7 0.3
Number of full brothers 1.0 1.2 1.6 -1.0 1.3 -1.0 -1.1
Worry too long after embarrassment 0.1 0.2 0.4 0.4 -0.7 -0.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.1 -1.1 0.6 -0.9 0.1
Wheeze or whistling in the chest in last year 1.0 1.8 2.9 -1.7 -1.1 -1.2 -1.3
Number of children fathered 2.3 2.6 4.4 -1.7 1.7 -2.1 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.4 -0.2 -0.8 -0.1 1.2
Age at first live birth 2.0 3.5 9.5 0.8 0.1 1.9 3.1
Pulse wave peak to peak time 0.8 0.9 2.3 0.3 0.4 1.1 1.5
Health satisfaction 0.5 0.7 1.0 -0.6 -0.7 -1.0 -1.0
Shortness of breath walking on level ground 0.2 0.3 0.5 0.5 -0.5 0.7 -0.2
Qualifications: College or University degree 1.1 3.4 11.6 -0.8 -1.1 -0.4 3.4
Eye problems/disorders: None of the above 1.6 1.8 4.7 -0.7 2.2 -0.8 -1.3
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.9 -1.0 -0.5 -0.8 -0.7
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.2 -0.4 -0.2 0.2
Medication for pain relief, constipation, heartburn 0.5 0.9 1.9 0.1 -1.2 0.3 1.4
Neck or shoulder pain in last month 1.9 2.7 5.0 1.1 2.2 1.0 -1.9
Medication: Blood pressure 1.1 2.0 5.0 1.2 1.0 2.2 -0.7
Angina (self-reported) 1.4 1.8 6.5 -0.2 0.8 -0.4 -2.5
Migraine (self-reported) 1.0 1.2 2.2 -1.5 -1.4 -0.8 0.0
Medication: Ibuprofen 0.3 0.3 0.9 -0.5 0.3 -0.9 -0.3
Medication: Allopurinol 0.5 0.6 1.9 0.2 -0.7 -0.2 -1.4
Medication: Omeprazole 0.3 0.4 0.8 0.1 -0.4 -0.6 -0.9
Medication: Seretide 50 evohaler 2.1 2.4 4.9 1.9 -1.0 2.2 -0.4
Mean time to correctly identify matches 0.4 0.7 1.6 0.4 -1.1 0.2 1.3
Heart disease (mother) 1.2 1.5 5.2 0.0 0.5 -0.6 -2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.3 0.0 -0.2 0.1 -1.1
Whole body fat mass 0.2 0.7 1.3 0.0 0.6 -1.1 -1.1
Leg fat mass (right) 0.2 0.9 2.8 0.3 0.3 -0.8 -1.7
Arm predicted mass (right) 1.7 8.7 22.8 -1.3 4.8 -2.4 -2.1
Pulse rate, automated reading 0.1 0.2 0.5 0.5 0.3 0.4 -0.7
Alcohol intake frequency. 0.6 1.3 3.7 0.7 1.9 0.3 -1.0
Comparative height size at age 10 0.5 2.7 5.2 -1.7 2.3 -1.4 0.9
Number of full sisters 1.0 1.2 1.7 1.1 0.9 1.3 -1.1
Suffer from ‘nerves’ 1.3 2.1 3.1 1.4 1.8 0.8 -1.6
Overall health rating 0.5 1.0 2.1 -0.1 -1.2 -0.7 -1.4
Chest pain or discomfort 1.1 1.6 1.7 -1.1 1.2 -1.3 -1.3
Had major operations 4.0 4.7 8.1 -1.6 2.6 -1.2 -2.9
Age at last live birth 1.0 1.4 2.8 1.1 -0.4 1.7 1.2
Family relationship satisfaction 0.9 1.1 1.7 0.8 -0.6 -1.3 1.3
Leg pain on walking 1.0 1.2 3.2 1.8 0.4 0.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 0.6 0.5 0.0 -1.0
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.5 0.5 1.6 -0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.8 1.3 -0.9 1.1 -0.0
Medication: Aspirin 1.2 1.6 3.6 1.3 0.5 1.0 -1.9
Supplements: Vitamin C 0.6 0.7 1.8 -0.2 -0.5 -1.4 -0.7
Knee pain experienced in last month 0.7 1.0 1.9 -0.6 -1.0 -0.9 1.4
Hypertension (Self-reported) 1.0 2.9 8.9 1.0 -0.5 1.2 -3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.5 -0.3 1.2 -0.8 -0.2
Illnesses of father: Heart disease 3.0 4.2 10.7 1.6 3.3 0.3 -1.9
Illnesses of siblings: Diabetes 1.5 1.8 5.7 -0.3 -0.1 1.2 -2.4
Smoking status: Previous 1.3 1.9 4.8 -0.2 2.2 -0.2 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 1.4 -1.2 1.1 -0.6 -0.2
Whole body fat-free mass 1.5 8.6 14.6 -2.3 3.8 -3.7 -0.8
Leg fat-free mass (right) 1.5 7.9 16.2 -2.5 3.0 -4.0 -0.1
Arm fat percentage (left) 0.2 0.8 2.4 -0.3 -0.7 -1.5 -0.4
Average weekly red wine intake 0.7 1.0 2.8 -0.5 0.3 -0.9 1.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.7 0.4 -1.3 0.7 0.5
Mood swings 0.5 0.9 1.4 -1.2 -0.8 -1.2 0.3
Loneliness, isolation 0.2 0.3 0.5 0.7 0.7 0.3 -0.3
Long-standing illness, disability or infirmity 0.2 0.4 0.9 -0.6 -0.9 -0.4 -0.1
Ever had bowel cancer screening 4.0 4.7 7.7 2.4 2.8 2.0 -1.2
Diabetes diagnosed by doctor 0.3 0.5 1.4 1.2 0.5 0.7 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 4.0 -0.0 -2.0 0.2 -0.4
Friendships satisfaction 0.6 0.7 1.5 1.2 0.3 1.1 -0.3
Qualifications: nursing, teaching 0.6 1.0 2.0 -0.0 -1.4 -0.1 1.4
Commuting to job workplace: Walk 0.2 0.2 0.6 -0.2 0.8 -0.0 -0.4
Eye problems/disorders: Cataract 2.7 3.1 6.8 2.6 -1.5 1.8 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.8 0.4 1.7 -0.2 0.1
Medication for cholesterol 0.5 0.8 2.6 -0.5 0.5 0.4 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.2 -0.6 0.8 -0.8 1.1
Back pain experienced in last month 0.6 0.8 1.9 1.4 -0.3 0.7 -0.9
Mineral and other dietary supplements 2.1 2.8 5.8 -2.4 -1.4 -1.3 1.4
Breast cancer (self-reported) 0.7 0.9 2.1 0.3 -1.0 -0.4 -1.4
Asthma (self-reported) 0.6 1.2 2.9 -0.4 -1.7 -0.3 -1.3
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.5 -0.7 0.1 0.2
Osteoarthritis (self-reported) 0.2 0.3 0.6 -0.8 -0.5 0.4 0.3
Medication: Aspirin 1.5 2.0 4.5 1.2 0.4 1.3 -2.1
Medication: Gliclazide 1.7 2.0 3.3 -1.8 -0.7 -1.8 -0.9
Illnesses of father: None of the above (group 1) 4.6 5.7 15.8 -1.2 -4.0 -0.2 2.3
Smoking status: Current 0.2 0.3 0.7 -0.1 0.9 -0.7 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 3.4 -1.5 1.9 0.1 -0.8
Whole body water mass 1.5 8.7 15.1 -2.3 3.9 -3.7 -0.9
Leg predicted mass (right) 1.5 7.8 15.8 -2.4 3.1 -4.0 -0.0
Arm fat mass (left) 0.4 1.5 4.8 -0.6 0.4 -2.2 -0.8
Number of self-reported non-cancer illnesses 0.6 1.1 1.8 -0.9 -1.2 -0.6 -1.4
Average weekly champagne plus white wine intake 1.4 1.9 2.8 1.3 -1.5 1.7 0.8
Miserableness 0.9 1.5 2.5 1.1 1.5 0.2 -1.6
Guilty feelings 0.1 0.2 0.2 0.4 0.5 -0.4 0.3
Wears glasses or contact lenses 1.6 1.8 4.0 0.5 -1.1 1.4 2.0
Ever taken oral contraceptive pill 1.1 1.2 3.7 0.5 1.9 0.1 1.0
Hearing aid user 0.3 0.3 1.0 -0.4 0.4 -0.1 1.0
Mother’s age at death 0.1 0.1 0.2 0.2 0.3 0.5 0.4
Financial situation satisfaction 0.5 0.6 1.6 0.8 -1.3 -0.1 0.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.4 0.7 -0.7 1.2 0.5
Commuting to job workplace: Public transport 2.7 3.2 8.5 -1.6 -2.9 -0.2 1.4
Eye problems/disorders: Glaucoma 1.6 1.9 2.2 -1.5 -1.5 -1.4 1.1
Medication: Blood pressure 0.7 1.4 4.0 0.0 -1.2 -0.5 -2.0
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.7 -0.8 0.8 -0.5 -1.3
Supplements: Fish oil (including cod liver oil) 1.2 1.6 5.5 2.3 0.2 0.3 0.9
High cholesterol (Self-reported) 2.3 4.0 7.5 1.8 1.0 2.7 -2.0
Medication: Bendroflumethiazide 0.8 1.3 2.2 1.4 -0.8 0.6 -1.5
Medication: Paracetamol 0.3 0.5 1.5 0.1 0.6 0.2 1.2
Medication: Lisinopril 2.6 3.3 4.7 1.7 -2.0 1.4 -2.2
Medication: Atorvastatin 1.7 2.1 5.5 0.8 1.3 0.6 -2.4
Illnesses of father: High blood pressure 0.8 1.0 2.3 0.3 1.1 -0.7 -1.5
Alcohol drinker status: Never 0.1 0.1 0.1 -0.3 -0.4 -0.3 0.3
Ever smoked 1.6 2.7 7.2 -1.0 2.7 -1.4 -0.9
Basal metabolic rate 1.3 7.2 12.5 -2.1 3.4 -3.5 -0.9
Leg fat percentage (left) 0.3 1.1 2.1 1.0 -1.1 0.3 -1.5
Arm fat-free mass (left) 1.3 6.8 13.4 -1.5 3.7 -2.9 -1.8
Number of operations (self-reported) 0.9 1.3 3.4 -0.8 0.6 -1.0 -1.8
Average weekly beer plus cider intake 0.4 0.5 1.9 0.2 0.2 -0.2 -1.4
Irritability 0.1 0.2 0.3 -0.5 -0.4 -0.1 -0.5
Risk taking 0.3 0.5 1.4 0.5 -0.4 0.4 -1.2
Ever had prostate specific antigen (PSA) test 1.7 1.9 5.0 1.0 2.2 1.0 0.9
Fractured/broken bones in last 5 years 0.5 0.7 1.6 -0.9 -1.3 0.5 0.2
Age started oral contraceptive pill 2.5 3.1 3.8 1.7 -2.0 1.9 1.4
Diastolic blood pressure, automated reading 1.4 4.2 16.6 0.4 0.4 0.2 -4.1
Ever depressed for a whole week 0.7 0.9 1.6 1.3 -1.1 -0.0 0.8
Unable to work because of sickness or disability 0.2 0.2 0.3 -0.5 -0.4 0.4 0.6
Commuting to job workplace: Cycle 1.7 2.0 3.6 -1.5 0.8 -1.9 -1.2
Myopia 1.1 1.5 2.2 1.3 -1.0 1.1 1.5
Vascular/heart problems diagnosed by doctor 1.6 4.4 13.6 -1.3 0.7 -1.3 3.7
Cholesterol lowering medication 0.8 1.2 3.3 0.9 0.4 0.8 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 0.6 -0.5 -0.7 -1.0
Pain experienced in last month 0.7 1.2 3.6 -0.6 -0.4 -0.9 1.9
Supplements: Calcium 0.5 0.6 1.0 1.0 -0.1 0.9 -0.7
Basal cell carcinoma (self-reported) 0.9 1.1 1.8 0.6 1.4 1.4 0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.5 0.7 -0.1 1.2 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 -0.2 0.2 0.7 -0.9
Heart disease (siblings) 1.4 1.7 3.8 -1.1 0.6 -1.1 -1.9
Alcohol drinker status: Previous 1.6 1.8 4.9 -0.9 2.2 -0.7 -0.9
Pack years of smoking 0.1 0.2 0.4 0.4 0.1 0.6 -0.4
Impedance of whole body 0.9 4.4 9.7 1.5 -2.3 3.1 0.6
Leg fat mass (left) 0.2 0.6 1.9 0.4 0.1 -0.8 -1.4
Arm predicted mass (left) 1.5 7.5 13.9 -1.7 3.7 -3.1 -1.9