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chr1:91,848,784-94,120,642

Best TWAS P=5.76e-14 · Best GWAS P=9.63e-15 conditioned to 6.01e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BTBD8	0.06	0.00	bslmm	441	0.02	1.3e-03	2.5	-5.2	2.6e-07	0.01	0.05	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EVI5	0.03	0.01	blup	335	0.02	1.3e-03	-6.9	-7.2	6.1e-13	-0.10	0.03	0.93	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.14	1.2e-16	-6.8	-7.4	1.5e-13	-0.10	0.04	0.96	FALSE
4	CommonMind	Brain Pre-frontal Cortex	RPAP2	0.20	0.06	enet	29	0.16	8.6e-19	-5.8	-6.2	6.3e-10	-0.10	0.15	0.85	FALSE
5	GTEx	Adipose Subcutaneous	EVI5	0.09	0.07	lasso	3	0.09	1.2e-07	-6.7	-7.0	2.4e-12	-0.09	0.56	0.44	FALSE
6	GTEx	Adipose Subcutaneous	FAM69A	0.08	0.06	lasso	7	0.04	3.8e-04	-5.4	6.0	2.7e-09	0.07	0.41	0.44	FALSE
7	GTEx	Adipose Visceral Omentum	EVI5	0.13	0.08	lasso	2	0.07	2.3e-04	-6.3	-6.3	3.3e-10	-0.05	0.49	0.09	FALSE
8	GTEx	Artery Coronary	EVI5	0.09	0.10	lasso	2	0.07	3.1e-03	-6.7	-6.7	2.6e-11	-0.10	0.17	0.21	FALSE
9	GTEx	Artery Coronary	FAM69A	0.25	0.25	lasso	2	0.26	3.4e-09	-5.4	5.7	9.5e-09	0.07	0.76	0.06	FALSE
10	GTEx	Artery Tibial	EVI5	0.08	0.08	lasso	10	0.12	9.5e-10	-6.2	-6.1	9.0e-10	-0.08	0.82	0.17	FALSE
11	GTEx	Brain Caudate basal ganglia	EVI5	0.10	0.00	enet	19	0.01	1.7e-01	-6.9	-6.3	3.7e-10	-0.07	0.11	0.11	FALSE
12	GTEx	Brain Cortex	EVI5	0.25	0.33	lasso	13	0.30	4.1e-09	-6.9	-7.0	2.6e-12	-0.09	0.37	0.62	FALSE
13	GTEx	Brain Hypothalamus	EVI5	0.16	0.12	lasso	13	0.05	2.1e-02	-6.9	-7.0	3.7e-12	-0.08	0.12	0.19	FALSE
14	GTEx	Breast Mammary Tissue	EVI5	0.07	0.06	lasso	4	0.07	2.3e-04	-6.9	-7.0	2.0e-12	-0.08	0.34	0.55	FALSE
15	GTEx	Breast Mammary Tissue (Male)	EVI5	0.17	0.03	lasso	10	0.08	5.9e-03	-6.2	-6.1	1.2e-09	-0.10	0.06	0.31	FALSE
16	GTEx	Cells Transformed fibroblasts	EVI5	0.18	0.11	enet	28	0.20	5.9e-15	-6.6	-7.3	1.9e-13	-0.06	0.73	0.27	FALSE
17	GTEx	Cells Transformed fibroblasts	FAM69A	0.24	0.19	lasso	7	0.17	4.9e-13	-5.4	5.3	1.3e-07	0.06	1.00	0.00	FALSE
18	GTEx	Colon Sigmoid	EVI5	0.13	0.16	lasso	3	0.12	7.0e-05	-6.9	-6.9	4.6e-12	-0.08	0.32	0.59	FALSE
19	GTEx	Colon Transverse	EVI5	0.21	0.08	lasso	9	0.14	4.2e-07	-5.4	-7.2	7.3e-13	-0.09	0.47	0.50	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	EVI5	0.22	0.10	lasso	7	0.06	2.3e-03	-6.3	-7.3	3.8e-13	-0.07	0.50	0.41	FALSE
21	GTEx	Esophagus Mucosa	EVI5	0.12	0.19	lasso	4	0.19	6.0e-13	-6.3	-7.1	9.1e-13	-0.07	0.61	0.39	FALSE
22	GTEx	Esophagus Muscularis	EVI5	0.16	0.23	lasso	5	0.23	4.9e-14	-6.3	-6.9	5.1e-12	-0.09	0.80	0.20	FALSE
23	GTEx	Heart Atrial Appendage	EVI5	0.09	0.06	lasso	7	0.05	4.2e-03	-6.9	-6.9	4.2e-12	-0.08	0.26	0.37	FALSE
24	GTEx	Heart Left Ventricle	EVI5	0.07	0.11	lasso	5	0.08	7.7e-05	-6.9	-7.2	4.7e-13	-0.09	0.33	0.61	FALSE
25	GTEx	Lung	EVI5	0.11	0.08	lasso	11	0.13	7.0e-10	-6.5	-7.5	5.8e-14	-0.08	0.47	0.53	TRUE
26	GTEx	Nerve Tibial	EVI5	0.17	0.13	enet	25	0.18	4.5e-13	-6.2	-6.9	4.1e-12	-0.08	0.76	0.24	FALSE
27	GTEx	Nerve Tibial	FAM69A	0.17	0.03	enet	19	0.05	1.4e-04	-5.0	5.3	9.2e-08	0.06	0.86	0.03	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	EVI5	0.07	0.05	lasso	6	0.08	2.2e-05	-6.2	-6.6	5.0e-11	-0.07	0.55	0.30	FALSE
29	GTEx	Spleen	EVI5	0.21	0.15	enet	22	0.25	3.3e-07	-6.9	-6.5	5.7e-11	-0.15	0.41	0.43	FALSE
30	GTEx	Stomach	EVI5	0.12	0.13	lasso	6	0.14	4.7e-07	-6.3	-5.7	1.4e-08	-0.04	0.87	0.12	FALSE
31	GTEx	Thyroid	RPAP2	0.04	0.03	enet	15	0.03	4.2e-03	4.5	-5.5	3.7e-08	-0.06	0.26	0.06	FALSE
32	GTEx	Thyroid	FAM69A	0.43	0.18	enet	41	0.20	5.5e-15	4.6	5.3	9.9e-08	0.01	1.00	0.00	FALSE
33	GTEx	Uterus	EVI5	0.23	0.12	enet	27	0.16	4.3e-04	-6.9	-6.7	1.7e-11	-0.10	0.27	0.24	FALSE
34	GTEx	Whole Blood	EVI5	0.03	0.01	lasso	2	0.01	6.8e-02	-6.9	-7.4	1.0e-13	-0.08	0.36	0.44	FALSE
35	METSIM	Adipose	EVI5	0.14	0.10	enet	35	0.11	1.0e-15	-6.2	-5.6	2.7e-08	-0.08	0.24	0.76	FALSE
36	METSIM	Adipose	FAM69A	0.03	0.03	bslmm	293	0.02	1.8e-03	-6.9	5.7	1.3e-08	0.06	0.04	0.94	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.15	2.4e-19	-3.6	-5.8	8.4e-09	-0.09	0.50	0.50	FALSE
38	YFS	Blood	FAM69A	0.28	0.09	enet	29	0.13	4.9e-40	4.6	6.0	2.1e-09	0.06	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI5	0.03	0.03	lasso	4	0.04	3.6e-09	-6.4	-7.4	1.0e-13	-0.08	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	EVI5	0.07	0.04	blup	93	0.03	4.7e-03	-6.9	-7.3	2.3e-13	-0.09	0.04	0.81	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM69A	0.05	0.01	enet	7	0.02	3.6e-02	-4.7	-5.8	8.0e-09	-0.12	0.02	0.74	FALSE
42	The Cancer Genome Atlas	Glioblastoma Multiforme	EVI5	0.14	0.04	blup	93	0.06	8.9e-03	-4.1	-6.3	2.5e-10	-0.08	0.03	0.70	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EVI5	0.08	0.04	blup	96	0.06	8.6e-08	-6.2	-7.1	1.4e-12	-0.08	0.04	0.96	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM69A	0.05	0.03	blup	62	0.05	4.4e-06	-6.6	-7.1	1.7e-12	-0.07	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI5	0.07	0.05	blup	96	0.06	2.5e-07	-6.4	-7.2	5.3e-13	-0.08	0.10	0.90	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EVI5	0.04	0.02	blup	96	0.04	1.4e-03	-4.1	-6.3	2.8e-10	-0.07	0.04	0.62	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI5	0.18	0.16	lasso	7	0.15	2.0e-16	-6.9	-7.3	2.3e-13	-0.08	0.30	0.70	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI5	0.05	0.07	lasso	5	0.07	5.6e-09	-6.4	-7.0	3.4e-12	-0.07	0.10	0.90	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI5	0.04	0.04	blup	93	0.03	4.8e-04	-6.3	-7.1	1.7e-12	-0.07	0.08	0.89	FALSE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EVI5	0.05	0.02	blup	96	0.03	2.3e-03	-6.9	-6.9	3.9e-12	-0.09	0.04	0.88	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EVI5	0.10	0.06	blup	94	0.08	2.9e-04	-6.9	-7.3	2.3e-13	-0.09	0.02	0.96	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI5	0.06	0.10	blup	94	0.10	1.7e-10	-6.9	-7.2	8.9e-13	-0.08	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI5	0.14	0.07	lasso	3	0.08	3.4e-06	-6.4	-5.9	4.5e-09	-0.06	0.18	0.80	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	EVI5	0.05	0.01	blup	94	0.03	5.7e-04	-6.6	5.9	3.4e-09	0.05	0.10	0.69	FALSE