TWAS hub - FAM69A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0980	0.0320	2.2e-13	0.132	0.120	0.134	0.121	0.140	8.8e-16	2.0e-14	5.6e-16	1.4e-14	1.2e-16
2	GTEx	Adipose Subcutaneous	0.0760	0.0360	5.7e-04	0.059	NA	0.026	NA	0.039	1.3e-05	NA	3.2e-03	NA	3.8e-04
3	GTEx	Artery Aorta	0.3380	0.0770	4.6e-10	0.219	NA	0.236	NA	0.269	2.7e-12	NA	3.0e-13	NA	3.9e-15
4	GTEx	Artery Coronary	0.2480	0.0960	2.5e-04	0.249	NA	0.179	NA	0.257	6.4e-09	NA	1.2e-06	NA	3.4e-09
5	GTEx	Artery Tibial	0.3536	0.0622	0.0e+00	0.337	NA	0.358	NA	0.356	3.0e-27	NA	3.6e-29	NA	5.3e-29
6	GTEx	Cells Transformed fibroblasts	0.2350	0.0590	1.7e-11	0.186	NA	0.165	NA	0.174	6.1e-14	NA	2.2e-12	NA	4.9e-13
7	GTEx	Nerve Tibial	0.1705	0.0518	7.2e-07	0.029	NA	0.052	NA	0.046	3.5e-03	NA	1.4e-04	NA	3.2e-04
8	GTEx	Pancreas	0.1000	0.0560	6.7e-03	0.082	NA	0.037	NA	0.035	2.4e-04	NA	1.1e-02	NA	1.2e-02
9	GTEx	Thyroid	0.4280	0.0810	1.2e-09	0.180	NA	0.197	NA	0.184	9.5e-14	NA	5.5e-15	NA	5.2e-14
10	METSIM	Adipose	0.0302	0.0172	1.8e-03	0.025	0.015	0.014	0.016	0.015	9.6e-05	1.8e-03	3.2e-03	1.7e-03	2.3e-03
11	ROSMAP	Brain Pre-frontal Cortex	0.0962	0.0323	1.2e-13	0.129	0.109	0.137	0.128	0.154	2.6e-16	8.2e-14	3.6e-17	4.3e-16	2.4e-19
12	YFS	Blood	0.2820	0.0545	0.0e+00	0.092	0.121	0.129	0.123	0.117	1.4e-28	1.8e-37	4.9e-40	5.5e-38	4.2e-36
13	TCGA	Colon Adenocarcinoma	0.0510	0.0400	5.8e-03	0.006	0.016	0.017	NA	0.008	1.3e-01	4.0e-02	3.6e-02	NA	1.0e-01
14	TCGA	Head and Neck Squamous Cell Carcinoma	0.0505	0.0261	1.4e-05	0.029	0.048	0.046	NA	0.042	3.1e-04	4.4e-06	6.8e-06	NA	1.6e-05
15	TCGA	Kidney Renal Clear Cell Carcinoma	0.1882	0.0830	1.0e-03	-0.002	0.008	0.019	NA	0.007	8.0e-01	3.5e-02	3.0e-03	NA	4.8e-02
16	TCGA	Thyroid Carcinoma	0.2500	0.1250	4.9e-04	0.063	0.009	0.044	NA	0.050	8.6e-07	4.5e-02	3.8e-05	NA	1.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Lung FEV1/FVC ratio	6.9	34.8	83.2	8.7	-4.8	-2.6	-3.6	-1.8	-2.8	-3.9	5.8	-6.4	-8.1	9.1	-6.5	7.5	8.5	-0.5	-4.0
Standing height	5.7	56.2	112.4	-10.6	8.1	6.5	7.8	5.2	7.4	7.6	-6.9	7.5	7.5	-8.5	7.6	-7.4	-9.7	1.7	5.9
Height	4.7	90.1	174.2	-13.2	9.7	7.7	8.7	5.7	8.0	9.8	-7.7	11.6	9.6	-12.0	10.6	-9.3	-12.1	2.7	8.1
Allergy or Eczema	4.6	12.0	27.2	-4.6	3.8	3.7	4.1	3.8	4.2	2.1	-3.8	1.0	5.2	-2.6	3.4	-2.8	-4.1	1.5	1.3
Comparative height size at age 10	4.4	24.1	45.6	-6.0	5.8	4.6	5.8	4.3	5.8	6.8	-2.4	6.3	3.0	-4.2	4.6	-2.9	-5.6	2.9	4.5
Hayfever, allergic rhinitis or eczema	4.3	9.2	24.4	-4.2	2.8	2.8	3.1	2.9	3.2	1.4	-3.5	1.1	4.9	-2.5	3.5	-2.8	-4.0	1.4	1.5
Chronotype (morning person)	4.2	9.7	31.3	4.1	-2.4	-2.7	-2.5	-1.8	-2.2	-1.7	5.3	0.7	-3.6	2.8	-1.6	5.6	3.3	3.6	1.3
Sitting height	4.2	29.6	54.5	-7.4	6.0	4.7	5.7	4.1	5.3	5.3	-4.7	5.3	5.7	-5.8	6.0	-5.8	-7.1	1.2	4.4
LDL Cholesterol	3.7	5.8	18.4	-3.8	2.9	1.9	2.4	1.7	2.2	2.7	-1.6	2.3	2.5	-4.3	0.9	-1.6	-2.5	1.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	8.9	2.0	-2.7	-2.3	-2.8	-2.3	-3.0	-1.0	0.8	-1.4	-2.1	0.9	-2.4	1.0	1.5	-0.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	3.2	5.0	11.7	-2.7	2.6	2.6	3.4	3.4	2.8	1.7	-3.0	-0.5	1.9	-0.8	-0.5	-2.7	-1.4	-1.1	-1.0
Crohns Disease (2012)	3.1	5.0	13.2	0.5	-3.5	-3.6	-3.1	-2.5	-3.4	-2.9	0.1	-1.9	-0.2	-0.7	-1.7	-0.4	0.8	-2.2	-2.5
Medication: Co-codamol	3.1	3.5	10.6	2.5	-0.1	-0.3	-0.6	-0.4	-0.8	0.0	3.0	0.1	-3.1	1.9	-2.2	3.2	3.0	1.5	-0.6
Mineral and other dietary supplements	3.1	4.1	8.8	3.0	-2.1	-2.1	-2.3	-1.9	-2.4	-1.7	2.2	-2.4	-1.8	1.1	-2.0	1.4	2.3	-0.2	-2.1
Allergy	3.0	6.9	21.2	3.8	-2.1	-1.9	-2.3	-2.1	-2.4	-1.0	3.1	-1.5	-4.6	2.3	-3.0	2.4	3.6	-1.6	-1.5
Major Depression (MDD)	2.9	3.5	13.2	-1.3	2.3	1.9	3.0	3.1	2.5	3.6	-0.5	1.3	0.7	0.0	1.3	-0.7	-1.3	0.9	0.6
Blood White Count	2.9	21.7	38.1	5.8	-5.1	-4.5	-4.8	-4.0	-4.5	-5.3	4.6	-4.4	-5.0	6.2	-5.9	4.1	4.0	-1.4	-2.3
Birth weight	2.9	6.3	12.2	-3.1	3.5	3.3	3.5	2.9	3.2	3.2	-2.0	0.9	1.8	-2.8	1.4	-2.5	-1.7	-0.3	-0.2
Fractured/broken bones in last 5 years	2.8	3.7	10.3	-1.6	3.2	2.8	2.9	2.7	2.0	2.5	-1.7	0.8	1.2	-0.8	1.0	-2.0	-1.1	0.4	-0.2
Supplements: Fish oil (including cod liver oil)	2.7	3.5	7.4	-2.7	2.2	2.0	2.4	1.9	2.3	1.9	-2.4	1.8	1.5	-1.4	1.1	-1.4	-2.1	-0.1	1.1
Respiratory disease	2.6	5.8	13.1	-3.6	2.4	1.9	2.5	1.9	2.1	1.7	-2.7	1.6	3.6	-2.5	2.6	-2.5	-3.1	-0.4	1.3
Ever depressed for a whole week	2.6	3.2	7.3	-1.5	2.4	2.7	2.4	2.0	2.4	1.1	-2.1	-0.8	2.0	-0.9	0.4	-2.1	-1.4	-1.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.9	9.3	-2.0	2.3	2.6	2.7	2.5	3.0	2.1	-0.8	2.0	1.6	-1.0	1.6	-0.5	-1.6	1.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	8.4	-1.7	2.4	2.7	2.5	2.4	2.9	2.6	-1.2	0.7	1.0	0.2	0.7	-0.4	-1.6	1.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	6.8	2.2	0.4	0.8	-0.2	0.4	-0.1	-0.3	2.3	-1.9	-2.0	2.6	-2.5	1.5	2.4	0.4	-1.7
BMI	2.4	13.8	42.2	5.5	-4.5	-3.4	-4.0	-3.0	-3.3	-2.7	4.7	-1.2	-4.5	6.5	-1.8	3.9	3.3	-0.2	0.5
Asthma (self-reported)	2.4	4.7	14.6	-3.3	1.8	1.7	1.7	1.2	1.5	1.1	-2.3	1.8	3.8	-2.4	2.6	-2.0	-2.9	0.4	1.5
Alcohol usually taken with meals	2.3	3.8	7.9	-2.3	1.9	1.4	1.9	1.8	1.4	0.2	-2.8	-2.4	2.8	-2.5	-0.9	-2.3	-1.4	-0.6	-2.2
Asthma	2.3	4.5	14.7	-3.2	1.7	1.6	1.5	1.0	1.4	1.0	-2.4	1.7	3.8	-2.5	2.4	-2.0	-2.8	0.5	1.4
Handedness (chirality/laterality): Left-handed	2.3	2.8	8.6	-1.0	2.8	2.9	2.6	2.5	2.8	2.0	-0.3	0.3	0.1	0.4	0.5	-0.5	-0.4	0.3	0.7
Eye problems/disorders: Cataract	2.3	2.7	6.8	-1.8	2.6	2.0	2.4	2.0	1.9	1.5	-1.7	-0.1	1.7	-1.5	-0.2	-1.6	-1.1	0.0	-1.0
Ovarian Cancer	2.2	2.9	7.2	2.6	-1.2	-1.0	-1.0	-0.4	-1.5	-0.9	1.6	-1.9	-1.8	1.6	-2.5	1.6	2.7	-0.6	-2.2
Illnesses of mother	2.2	2.7	9.7	-2.5	1.5	0.9	1.2	0.4	0.8	1.0	-1.8	1.1	1.6	-3.1	1.0	-2.5	-1.9	-1.4	0.6
Medication for pain relief, constipation, heartburn	2.2	3.8	9.5	-2.9	1.0	0.5	1.1	0.2	0.8	0.0	-3.0	0.6	2.8	-2.2	2.5	-3.0	-3.1	-1.1	1.0
Heart disease (mother)	2.2	2.7	8.1	2.6	-1.6	-1.0	-1.2	-0.5	-0.9	-0.7	2.2	-0.9	-2.0	2.3	-0.7	2.8	2.3	1.0	-0.9
Pack years adult smoking proportion	2.1	3.3	8.2	2.5	-1.8	-1.7	-1.6	-1.1	-1.4	-0.8	2.3	-0.9	-2.9	2.3	-2.2	2.1	2.1	-0.0	-0.9
Body mass index (BMI)	2.1	9.0	22.8	4.4	-3.7	-2.9	-3.6	-3.1	-3.2	-2.5	3.5	-0.0	-3.2	4.8	-1.0	3.3	2.4	0.4	0.9
Trunk fat-free mass	2.1	12.2	31.4	-3.5	3.5	2.9	3.2	2.0	3.5	3.8	-1.5	4.9	2.6	-0.7	4.9	-1.6	-4.8	2.5	5.6
Trunk predicted mass	2.1	12.0	31.8	-3.5	3.5	2.9	3.1	2.0	3.4	3.7	-1.5	4.9	2.5	-0.7	4.9	-1.4	-4.8	2.6	5.6
Tense / ‘highly strung’	2.1	3.5	9.3	-1.0	2.6	2.3	3.0	2.9	3.0	2.4	-0.5	1.2	1.2	0.3	0.8	0.8	-0.6	2.2	1.1
Supplements: Calcium	2.1	2.4	3.4	-1.8	1.7	1.5	1.7	1.8	1.5	1.6	-1.4	1.6	1.8	-0.9	1.8	-0.9	-1.1	1.5	1.3
Schizophrenia (2018)	2.0	4.1	6.7	-2.4	2.6	2.3	2.6	2.0	2.3	2.4	-2.2	1.5	1.6	-2.1	2.2	-1.9	-1.3	0.3	0.8
Hand grip strength (right)	2.0	5.4	11.4	-3.0	3.1	2.5	2.7	2.6	2.7	3.4	-1.2	1.8	1.3	-1.7	1.6	-2.3	-2.9	1.0	1.6
Current tobacco smoking	2.0	3.3	6.6	2.6	-1.8	-1.6	-1.8	-1.7	-2.0	-2.2	1.2	-1.2	-1.8	1.6	-2.4	1.8	2.4	-0.3	-1.5
Mood swings	2.0	3.6	9.8	-2.3	1.6	1.3	1.1	0.5	1.4	0.4	-1.4	3.1	3.0	-2.5	2.3	-1.5	-2.1	0.2	2.4
Hand grip strength (left)	1.9	5.1	10.6	-3.2	2.9	2.3	2.5	2.0	2.6	2.2	-2.2	1.5	1.5	-1.7	1.6	-2.5	-3.1	0.1	2.0
Average weekly fortified wine intake	1.9	2.3	5.3	-1.6	-0.9	-1.4	-1.0	-1.6	-1.1	-1.5	-1.8	0.7	1.7	-2.3	0.7	-2.3	-1.8	-1.7	0.2
Number of live births	1.9	2.7	6.1	2.3	-1.9	-1.6	-1.6	-1.5	-2.0	-1.8	1.6	-0.3	-1.8	1.4	-1.1	2.1	2.5	0.1	-0.9
Chronic bronchitis/emphysema (mother)	1.9	2.2	8.9	1.9	-0.4	0.1	-0.1	0.4	0.4	1.2	2.2	-0.9	-2.1	3.0	-1.5	2.1	1.6	1.3	-0.6
Arm fat percentage (left)	1.9	7.4	13.8	3.6	-3.7	-3.2	-3.7	-3.4	-3.5	-2.3	2.8	0.6	-2.8	3.1	-0.9	2.7	2.0	0.1	0.6
Guilty feelings	1.9	2.9	10.3	1.1	-2.8	-2.5	-2.1	-2.2	-1.6	-3.2	0.9	0.5	-0.4	1.4	-0.1	1.5	-0.0	0.2	1.8
Schizophrenia (2014)	1.8	3.9	8.9	-1.9	2.9	2.5	3.0	2.8	2.6	2.9	-1.1	1.2	1.3	-1.4	1.5	-0.9	-0.7	1.0	0.5
Arm fat percentage (right)	1.8	7.1	14.1	3.3	-3.8	-3.4	-3.7	-3.5	-3.6	-2.5	2.5	0.7	-2.5	2.9	-0.7	2.6	1.7	0.2	0.8
Birth weight of first child	1.8	3.2	8.7	-3.0	1.8	1.4	1.4	0.6	1.6	0.5	-2.4	0.9	1.5	-2.9	1.7	-2.5	-2.1	-0.9	0.9
Loud music exposure frequency	1.8	2.0	9.8	1.0	-0.5	-0.2	-0.7	-0.1	-0.8	-0.9	0.8	-3.0	-0.6	0.1	-2.8	0.3	1.3	-0.2	-3.1
Comparative body size at age 10	1.8	5.0	14.4	3.8	-1.9	-1.5	-1.7	-0.8	-1.7	-1.8	2.1	-2.6	-2.9	3.3	-1.4	2.1	3.1	-0.4	-2.1
Pack years of smoking	1.8	2.6	7.5	2.1	-1.6	-1.5	-1.4	-0.9	-1.2	-0.4	2.2	-0.4	-2.7	2.0	-2.2	1.9	1.8	0.1	-0.6
Prostate Cancer	1.7	2.4	6.3	1.2	-2.0	-2.3	-2.2	-2.4	-2.5	-2.3	0.9	-1.1	-0.5	0.5	-1.3	0.2	-0.2	-1.3	-0.4
Maternal smoking around birth	1.7	2.4	9.2	1.4	-0.5	-0.2	-0.7	-0.5	-0.6	-0.9	0.8	-2.7	-1.3	1.4	-2.7	0.4	1.8	-1.6	-3.0
Supplements: Glucosamine	1.7	2.2	9.4	-2.2	1.0	0.9	0.8	0.1	1.2	0.7	-1.2	2.2	1.6	-0.8	1.6	-0.3	-2.1	1.0	3.1
Medication: Ramipril	1.7	2.2	8.1	1.9	-0.5	-0.1	-0.1	0.4	0.2	0.5	1.4	-0.8	-1.7	2.9	-2.0	2.7	1.6	1.8	-0.8
High blood pressure (siblings)	1.7	2.5	5.6	1.8	-2.3	-1.9	-2.1	-1.8	-1.7	-0.2	2.4	0.7	-2.1	2.0	-0.1	1.4	0.2	0.5	0.8
Leg fat percentage (right)	1.7	6.1	11.5	3.4	-3.1	-2.9	-3.3	-2.9	-3.4	-2.4	2.5	-0.2	-2.4	2.5	-1.8	2.3	2.2	-0.4	-0.4
Suffer from ‘nerves’	1.7	2.7	9.2	-1.8	1.8	1.4	2.0	2.2	2.1	3.0	-0.7	1.6	1.0	-0.9	0.7	-0.6	-1.6	1.7	1.1
Commuting to job workplace: Car/motor vehicle	1.7	1.9	5.1	0.5	1.7	2.3	1.7	2.2	2.2	1.6	1.0	-0.4	0.3	1.0	-0.4	0.6	0.8	1.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	7.8	-2.8	1.7	1.7	2.2	2.1	2.3	2.5	-2.3	0.5	1.5	-1.4	1.5	-2.0	-2.3	1.0	0.6
Whole body fat-free mass	1.7	10.0	29.8	-3.0	2.8	2.5	2.5	1.4	2.8	3.4	-1.3	4.9	2.1	-0.4	4.7	-1.4	-4.4	2.3	5.5
Whole body water mass	1.7	9.5	29.7	-2.9	2.7	2.4	2.4	1.3	2.7	3.2	-1.2	4.8	2.0	-0.3	4.6	-1.2	-4.3	2.3	5.5
Vascular/heart problems diagnosed by doctor	1.7	4.6	15.1	-3.8	1.8	0.7	1.4	0.6	0.9	0.9	-2.5	-0.1	2.8	-3.9	1.3	-3.4	-2.9	-1.1	0.4
Blood Platelet Count	1.6	18.8	47.1	5.1	-4.1	-3.6	-3.0	-1.8	-3.0	-6.0	2.0	-6.9	-4.8	5.0	-5.9	2.5	4.8	-2.7	-4.1
Financial difficulties in last 2 years	1.6	2.1	5.7	2.0	-0.9	-0.5	-0.8	-0.2	-1.0	-0.5	1.7	-1.8	-1.5	1.6	-2.4	1.7	2.1	0.1	-1.4
Mouth/teeth dental problems: Dentures	1.6	2.7	8.8	2.2	-1.5	-1.4	-1.7	-1.5	-1.7	-0.3	1.5	0.4	-3.0	1.4	-2.4	1.0	1.9	-1.1	-1.1
Medication: Blood pressure	1.6	2.8	10.5	2.2	-0.1	0.7	0.3	0.9	1.0	1.0	2.3	0.6	-2.0	3.2	-0.3	2.8	1.5	2.1	1.1
Smoking status: Current	1.6	2.6	5.7	2.4	-1.7	-1.4	-1.5	-1.3	-1.7	-1.7	1.3	-0.7	-2.0	1.6	-1.9	1.7	2.3	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	8.4	2.0	-2.4	-1.8	-2.8	-2.6	-2.3	-2.9	0.9	-1.3	-1.3	1.2	-1.0	1.9	1.5	-0.2	-0.1
Wears glasses or contact lenses	1.6	1.9	4.8	2.2	-1.3	-0.5	-1.3	-0.9	-0.9	-1.2	1.6	-0.8	-1.5	1.6	-1.2	1.6	1.9	-0.3	-1.4
Illnesses of father: High blood pressure	1.6	2.0	5.6	1.9	-0.7	-0.3	-1.1	-0.9	-1.9	-0.0	0.1	-1.5	-1.6	0.4	-2.0	0.1	1.8	-1.9	-2.4
Bipolar Disorder or Schizophrenia	1.5	3.6	6.4	-2.1	2.3	2.3	2.4	1.9	2.5	2.3	-1.3	1.6	1.8	-1.8	2.5	-1.2	-1.2	0.6	1.1
Rheumatoid Arthritis	1.5	2.1	6.9	2.0	0.2	0.5	-0.6	-0.4	-1.2	0.6	2.0	-0.6	-1.8	0.1	-2.2	1.0	2.6	-0.5	-2.5
Ever used hormone-replacement therapy (HRT)	1.5	2.0	8.1	-1.7	0.7	0.0	0.6	0.1	0.5	0.8	-0.8	2.8	1.3	-0.9	1.9	-0.4	-1.9	1.7	2.3
Medication: Atenolol	1.5	1.9	5.2	2.3	-1.7	-1.0	-1.6	-1.5	-1.4	-0.6	1.4	0.3	-1.8	1.8	-0.3	1.6	1.5	-0.3	0.5
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.8	-1.9	1.8	1.6	1.9	1.9	1.9	0.9	-1.2	-0.3	1.8	-1.4	0.3	-1.3	-1.4	0.1	-0.3
Family relationship satisfaction	1.5	1.9	7.7	1.6	-1.2	-0.5	-0.8	-0.3	-0.0	-2.0	0.6	-2.8	-0.6	1.8	-1.7	1.4	1.4	0.7	-1.4
Miserableness	1.5	2.5	5.6	-2.0	1.3	1.1	1.4	1.4	1.7	1.1	-1.8	1.4	1.9	-0.9	1.9	-2.3	-2.4	-0.0	1.0
Medication: Blood pressure	1.5	2.9	9.4	3.1	-1.2	-0.7	-1.0	-0.5	-0.9	-0.7	1.7	-0.7	-2.6	2.7	-0.9	2.4	2.5	0.9	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	5.4	0.4	0.8	0.9	1.7	2.3	1.7	1.9	0.6	-0.1	-1.6	1.6	-1.2	0.9	1.0	1.5	-1.2
Arm predicted mass (left)	1.5	7.5	21.6	-2.5	2.7	2.3	2.4	1.3	2.5	2.8	-1.2	4.3	1.9	-0.4	4.0	-1.3	-3.8	1.8	4.7
Irritable Bowel Disease (IBD)	1.4	3.4	12.3	-0.9	-3.0	-3.5	-2.1	-2.0	-2.3	-2.4	-1.4	-0.2	0.8	-1.1	0.7	-1.3	-1.1	-2.0	-0.2
HbA1C	1.4	1.5	6.1	1.5	-1.1	-1.1	-0.6	-0.1	-0.6	-0.6	0.2	-1.9	-1.4	1.6	-0.8	0.8	1.7	0.2	-2.5
Age when periods started (menarche)	1.4	3.3	8.5	-2.4	1.4	1.3	1.1	0.5	1.6	0.9	-2.0	1.9	2.7	-1.7	1.9	-2.1	-2.9	0.1	2.1
Fluid intelligence score	1.4	3.0	8.0	-2.2	2.1	2.2	1.4	1.3	1.3	0.0	-2.7	-0.6	2.8	-2.3	0.8	-2.0	-1.3	-0.6	-0.8
Father’s age at death	1.4	1.9	7.3	-0.1	2.1	2.7	1.8	2.0	2.3	1.8	0.0	-0.1	0.3	0.8	0.3	0.5	0.1	1.3	-0.3
Forced vital capacity (FVC), Best measure	1.4	5.3	10.6	-3.2	2.6	2.5	2.2	1.5	2.4	1.5	-2.4	1.5	1.9	-2.3	3.2	-2.4	-2.9	0.3	2.2
Arm fat-free mass (right)	1.4	7.3	18.8	-2.3	2.8	2.5	2.5	1.6	2.8	3.4	-0.8	4.2	1.4	-0.0	3.7	-1.2	-3.5	1.9	4.3
Commuting to job workplace: Walk	1.4	1.6	4.2	-1.5	0.3	-0.3	0.2	-0.4	-0.4	-0.3	-1.8	0.7	1.5	-0.7	2.0	-1.8	-1.5	-1.8	1.5
Basal metabolic rate	1.4	7.6	25.8	-2.4	2.2	1.9	2.0	1.0	2.2	2.9	-0.9	4.6	1.6	-0.1	4.3	-1.1	-3.9	2.0	5.1
Leg fat percentage (left)	1.4	5.2	10.8	3.3	-2.7	-2.5	-2.9	-2.6	-3.0	-2.0	2.4	-0.1	-2.4	2.4	-1.8	2.1	2.2	-0.5	-0.5
Arm fat-free mass (left)	1.4	7.2	19.8	-2.4	2.8	2.3	2.4	1.4	2.5	2.9	-1.1	4.2	1.7	-0.4	3.8	-1.3	-3.7	1.7	4.5
Diastolic blood pressure, automated reading	1.4	4.4	10.5	2.3	-3.1	-3.2	-2.8	-2.6	-3.0	-0.8	2.0	0.6	-2.8	1.9	-1.2	1.3	1.1	-0.8	-0.1
Heel T-Score	1.3	10.0	22.9	4.4	-3.2	-3.2	-2.5	-1.5	-2.4	-2.7	2.8	-3.4	-4.1	4.8	-3.7	3.6	3.3	0.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.9	-0.8	1.6	1.8	2.2	2.4	2.1	1.9	-1.4	0.5	1.4	0.3	1.2	-0.6	-0.8	0.6	0.2
Time employed in main current job	1.3	1.5	3.8	-1.7	1.2	1.1	0.8	0.5	0.9	0.3	-1.8	-0.7	1.7	-1.5	0.7	-2.0	-1.5	-0.8	-0.5
Falls in the last year	1.3	1.7	7.4	1.1	-0.5	0.0	-0.9	-1.2	-0.8	-1.7	0.5	-2.2	-0.8	0.1	-2.7	0.0	1.3	-1.6	-1.8
Prospective memory result	1.3	1.6	5.2	1.3	-0.1	-0.1	-0.0	0.4	0.3	1.2	1.8	1.3	-1.3	1.8	0.3	2.0	0.7	2.3	1.4
Exposure to tobacco smoke at home	1.3	1.4	4.4	1.4	-0.9	-1.3	-0.9	-0.6	-0.7	-1.0	2.1	0.6	-1.6	0.9	-0.6	1.9	1.6	0.8	0.9
Pulse wave reflection index	1.3	1.7	7.0	1.9	-0.5	-0.2	-0.4	-0.6	-0.2	-0.5	2.0	-0.1	-1.4	2.6	-0.3	2.2	1.0	1.1	1.3
Arm predicted mass (right)	1.3	6.8	17.9	-2.3	2.7	2.4	2.4	1.6	2.6	3.2	-0.9	4.0	1.3	-0.0	3.6	-1.2	-3.4	1.6	4.2
Leg fat-free mass (right)	1.3	6.8	23.9	-2.3	1.9	1.7	1.7	0.8	2.0	2.6	-0.9	4.3	1.5	0.1	4.2	-1.1	-3.8	1.8	4.9
Leg predicted mass (right)	1.3	7.0	24.3	-2.4	1.8	1.7	1.7	0.7	2.0	2.6	-1.0	4.5	1.6	0.0	4.3	-1.2	-3.9	1.8	4.9
Depressed Affect (Nagel 2018)	1.2	2.6	12.5	-1.4	0.5	0.8	0.4	-0.2	1.1	0.8	-0.4	3.5	1.4	-0.7	2.4	-0.7	-2.3	0.1	3.1
Alzheimer’s Disease (in father)	1.2	1.3	4.0	0.4	-1.7	-1.6	-2.0	-1.9	-1.8	-1.5	-0.1	0.3	0.2	-0.2	0.4	-0.1	-0.6	-0.3	0.9
Crohns Disease (2017)	1.2	2.5	9.1	-1.6	-2.0	-3.0	-1.2	-1.1	-1.8	-1.4	-1.5	-0.4	1.1	-2.0	0.4	-1.7	-1.4	-2.0	-0.4
Age at First Birth	1.2	1.7	4.3	-2.0	0.8	0.6	1.3	0.8	1.5	0.7	-1.5	0.8	1.4	-0.0	1.8	-1.2	-2.1	-0.4	1.7
Blood Red Count	1.2	12.0	32.9	5.1	-1.2	-1.0	-2.0	-1.4	-2.6	0.1	5.7	-1.0	-5.5	2.8	-5.1	4.0	5.0	1.1	-3.2
Relative age of first facial hair	1.2	2.4	4.5	-1.6	2.0	1.9	2.1	2.0	1.9	1.6	-2.1	-0.9	1.8	-0.5	-0.2	-1.6	-1.0	-0.7	-1.0
Medication for hormone replacement therapy	1.2	1.3	3.8	-1.5	0.8	0.3	0.9	0.7	0.7	0.2	-1.2	1.4	1.3	-0.2	1.5	-2.0	-1.9	0.2	1.1
Leg fat-free mass (left)	1.2	6.3	24.2	-2.3	1.5	1.3	1.4	0.4	1.6	2.4	-0.9	4.3	1.5	0.1	4.1	-1.0	-3.7	1.8	4.9
Leg predicted mass (left)	1.2	6.4	24.4	-2.3	1.5	1.3	1.4	0.5	1.6	2.4	-1.0	4.4	1.6	0.1	4.1	-1.1	-3.8	1.8	4.9
Waist circumference	1.2	4.4	11.0	2.9	-2.9	-2.1	-2.7	-2.4	-2.4	-1.8	2.1	0.4	-2.0	3.3	-0.3	2.1	1.1	0.5	1.0
Forced vital capacity (FVC)	1.2	4.5	8.6	-2.7	2.7	2.6	2.1	1.4	2.3	1.9	-1.6	2.0	1.2	-2.0	2.9	-2.1	-2.2	0.5	2.1
Illnesses of siblings	1.2	1.7	4.5	-1.9	1.5	1.3	1.3	0.7	1.2	0.0	-2.0	-0.4	2.0	-2.1	0.8	-1.4	-0.8	-1.0	0.0
Length of working week for main job	1.2	1.3	4.7	0.2	1.8	2.0	1.3	1.5	1.3	2.2	-0.4	-0.7	0.5	0.5	0.2	0.5	0.1	1.3	-0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.6	4.1	-1.2	1.5	1.8	1.8	2.0	1.6	1.6	-0.3	1.1	0.6	-0.7	-0.7	0.2	-0.1	1.8	-0.0
Exposure to tobacco smoke outside home	1.2	1.7	4.6	1.0	0.7	0.8	0.8	1.0	0.9	1.4	1.9	0.9	-1.9	1.3	-1.1	2.2	1.3	1.8	0.1
Pulse wave peak to peak time	1.2	1.4	4.1	-1.8	1.0	0.8	0.8	0.9	1.1	0.6	-1.7	-0.9	0.9	-1.8	0.5	-2.0	-1.1	-0.7	-0.8
Medication: Aspirin	1.2	1.6	4.4	2.1	-1.3	-1.3	-1.4	-0.8	-1.4	-1.5	1.5	-0.4	-1.0	1.5	-0.5	1.3	1.5	0.6	0.2
Medication: Lisinopril	1.2	1.6	3.9	2.0	-0.9	-0.5	-0.8	-0.6	-0.8	-1.2	1.0	-1.3	-1.7	1.1	-1.5	1.8	1.9	-0.1	-1.3
Mean Putamen Volume	1.1	1.3	7.9	0.6	-1.1	-1.5	-0.8	-0.5	-0.9	-1.7	-0.1	-2.8	-0.1	0.7	-1.5	0.1	0.2	-0.4	-1.4
Ever had hysterectomy (womb removed)	1.1	1.3	3.3	0.8	1.2	1.2	1.1	1.7	0.9	0.9	1.8	-0.8	-0.7	0.7	-0.7	0.9	1.5	0.7	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	6.7	2.3	-1.4	-1.0	-1.2	-0.7	-1.2	-1.4	0.6	-2.3	-1.0	1.7	-2.6	1.7	1.7	0.5	-1.8
Medication: Levothyroxine sodium	1.1	1.9	3.6	1.7	-0.9	-1.2	-1.5	-1.6	-1.6	-1.5	1.9	-0.2	-1.8	1.1	-1.5	1.6	1.7	-0.3	-0.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.5	-0.8	1.6	1.8	1.7	1.5	1.9	0.6	-0.8	0.1	1.1	0.5	0.8	-0.7	-1.2	-0.2	1.0
Diabetes (self-reported)	1.1	1.7	5.2	1.4	-0.8	-0.3	-1.2	-0.9	-0.8	-0.0	1.8	2.2	-0.8	1.5	1.1	1.9	0.3	0.9	2.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	6.0	-0.4	0.2	0.2	-0.1	-0.1	-0.7	-1.5	-1.6	-2.4	0.2	-1.2	-1.0	-1.7	0.5	-2.1	-2.5
Migraine (self-reported)	1.1	1.4	5.0	1.7	-0.2	0.2	-0.6	-0.4	-0.6	-1.4	0.7	-2.2	-0.6	-0.1	-1.5	0.2	1.8	-1.1	-2.1
Leg pain on walking	1.1	1.4	5.1	0.9	0.6	1.5	0.7	0.8	1.5	1.2	0.8	0.7	0.0	1.3	-0.2	2.2	0.9	2.3	0.2
Medication: Aspirin	1.1	1.5	4.9	2.2	-1.0	-1.0	-1.1	-0.5	-1.1	-1.4	1.4	-0.5	-0.9	1.7	-0.7	1.4	1.7	0.7	-0.3
High cholesterol (Self-reported)	1.1	1.9	7.8	-0.1	1.9	2.0	1.6	1.4	1.3	2.0	-0.0	2.8	0.1	-0.2	0.3	0.2	-0.6	2.0	1.0
Irritability	1.1	1.9	4.5	-1.7	2.0	1.6	2.1	1.8	2.1	1.3	-0.9	1.1	0.9	-1.3	0.3	-0.8	-1.3	0.5	0.7
Alzheimer’s Disease (in mother)	1.0	1.2	3.1	-1.7	0.3	0.1	0.5	0.1	0.6	-0.1	-1.4	1.6	1.1	-1.1	1.6	-0.9	-1.3	-0.1	1.8
Ulcerative Colitis (UC)	1.0	1.9	6.5	-0.2	-2.5	-2.5	-1.8	-1.8	-1.6	-2.2	-0.8	0.2	0.3	0.1	0.8	-0.4	-0.6	-1.1	0.4
Fasting Glucose	1.0	1.2	4.7	-0.7	1.0	1.1	1.2	1.3	0.8	-0.1	-0.7	-0.8	0.7	-1.4	-0.4	-1.5	-0.0	-1.6	-2.2
Average weekly spirits intake	1.0	1.2	3.2	-0.1	-0.9	-1.2	-0.8	-1.6	-0.9	-1.5	-0.5	1.7	-0.4	0.1	1.2	-0.7	-0.8	-1.3	1.8
Hearing difficulty/problems: Yes	1.0	1.5	5.7	1.2	-1.5	-1.3	-1.2	-1.3	-0.9	-2.4	1.1	-1.6	-0.6	1.0	-1.1	0.8	0.8	-1.0	-0.3
Number of incorrect matches in round	1.0	1.6	8.2	-0.7	0.7	0.7	1.0	1.2	1.3	2.9	0.1	2.2	-0.1	0.6	0.2	0.6	-0.9	2.0	1.3
Qualifications: None of the above	1.0	2.1	13.8	0.7	0.5	0.1	0.1	0.1	0.4	2.1	1.9	3.7	-1.2	0.0	0.2	1.6	0.4	2.1	1.7
Neuroticism score	1.0	2.1	5.7	-1.5	1.1	0.9	1.3	0.8	1.6	0.8	-1.1	2.3	1.5	-0.7	1.9	-0.8	-1.9	0.3	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.6	0.8	-1.6	-1.5	-1.6	-1.1	-1.5	-1.2	1.1	-0.9	-0.8	0.0	-1.6	1.0	0.9	0.3	-0.7
Body fat percentage	1.0	4.0	9.3	2.3	-2.9	-2.7	-2.9	-2.9	-3.0	-1.7	1.8	1.1	-1.9	1.3	-0.9	1.4	1.3	-0.4	0.2
Shortness of breath walking on level ground	1.0	1.2	5.2	1.4	0.3	1.0	0.8	1.2	1.1	1.0	1.3	-0.3	-1.2	2.3	0.1	1.1	0.8	1.2	0.2
Medication: Omeprazole	1.0	1.2	4.3	0.4	0.7	0.8	1.6	2.1	1.4	1.5	0.4	-0.3	-1.2	1.4	-0.8	0.6	0.8	1.0	-1.1
Osteoarthritis (self-reported)	1.0	1.3	3.2	-1.4	0.7	1.1	0.7	0.1	0.4	0.2	-1.7	1.8	1.2	-0.7	1.0	-1.4	-1.3	-1.3	1.3
Number of self-reported non-cancer illnesses	1.0	1.7	5.6	-1.1	1.1	1.5	0.7	0.3	0.8	0.7	-1.1	2.4	1.6	-0.6	1.7	-0.8	-1.9	0.1	2.0
Hearing aid user	1.0	1.2	3.6	0.4	-1.1	-1.4	-1.1	-1.0	-1.3	-1.9	-0.0	-1.9	0.9	0.1	-0.3	-0.4	-0.1	-1.5	-0.9
Mother’s age at death	1.0	1.2	4.1	-1.4	-0.3	-0.6	-0.0	-0.3	0.2	-0.1	-1.7	0.7	1.5	-0.8	1.4	-1.7	-2.0	-0.1	1.0
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.6	0.6	1.0	1.3	1.3	1.5	1.4	1.4	0.6	-1.6	-0.6	1.0	-1.2	0.2	0.3	0.5	-1.4
Schizophrenia vs Biploar Disorder	0.9	1.1	3.1	-1.2	1.8	1.1	1.4	1.3	0.9	1.2	-1.1	0.6	1.0	-0.9	0.5	-1.0	-0.8	1.1	0.1
Blood Eosinophil Count	0.9	7.2	23.3	0.2	-2.3	-2.2	-1.6	-1.9	-2.3	-3.5	-3.1	-4.8	0.2	0.5	-1.9	-3.1	-0.4	-4.8	-3.5
Smoking Status	0.9	2.1	4.4	1.4	-1.9	-1.4	-1.9	-1.8	-2.1	-2.1	0.3	-1.0	-1.1	1.1	-0.6	0.1	1.3	-1.9	-1.2
Taking other prescription medications	0.9	1.3	8.6	-0.6	1.1	1.1	0.3	0.0	0.1	1.4	0.1	2.9	1.0	-1.7	0.7	-0.0	-0.9	1.3	1.0
Qualifications: CSEs or equivalent	0.9	1.2	2.8	1.6	-1.4	-0.8	-1.3	-1.0	-1.1	-0.6	1.4	-0.9	-1.7	0.5	-0.8	0.7	1.3	-0.5	-1.1
High blood pressure	0.9	2.6	11.2	2.9	-1.2	-0.1	-0.8	-0.0	-0.3	-0.5	1.7	0.1	-1.9	3.3	-1.0	2.6	2.0	0.9	-0.6
Impedance of leg (left)	0.9	4.6	23.4	-2.3	1.9	1.1	1.6	1.5	0.8	1.1	-2.1	-1.1	1.4	-4.8	-1.7	-2.8	-0.0	-1.7	-3.5
Medication: Lansoprazole	0.9	1.0	4.1	0.7	1.7	2.0	1.1	1.6	0.7	0.8	0.7	0.1	-0.1	0.4	-0.8	0.3	1.0	0.1	-1.0
Glaucoma (self-reported)	0.9	1.0	2.8	-1.0	1.1	0.7	0.5	-0.3	0.0	-0.2	-1.0	1.5	0.9	-1.5	1.2	-0.7	-1.0	-1.1	1.7
Chest pain or discomfort	0.9	1.3	3.7	0.7	-1.4	-1.2	-1.8	-1.8	-1.9	-1.6	1.0	0.6	-0.8	-0.7	-0.5	0.1	0.4	-0.1	0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	-1.5	1.4	1.1	1.8	1.5	1.6	0.9	-1.1	-0.1	1.0	-0.9	0.1	-0.7	-0.2	-0.1	-0.3
Commuting to job workplace: Cycle	0.9	1.1	3.7	-0.4	-1.1	-1.3	-1.4	-1.6	-1.4	-1.9	-1.2	-0.3	0.6	-1.3	0.0	0.0	-0.4	-0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.8	1.2	-0.2	0.4	0.4	1.1	0.7	-0.3	1.4	-0.1	-1.4	2.2	-0.3	1.7	1.6	1.0	0.4
Impedance of whole body	0.9	4.5	28.3	-2.9	1.3	0.6	1.3	0.9	0.5	1.0	-2.6	-0.3	1.9	-5.3	-1.0	-2.9	-0.7	-1.3	-2.8
Neuroticism (Nagel 2018)	0.8	2.0	9.3	-1.0	0.3	0.2	0.3	-0.2	1.0	0.1	-0.4	2.9	1.3	0.1	2.4	0.2	-1.7	1.0	3.1
Lupus	0.8	1.2	3.5	1.4	1.1	1.9	0.0	-0.4	0.1	-0.2	1.4	1.2	-1.7	0.4	-1.4	1.4	1.5	0.4	0.3
Primary Biliary Cirrhosis	0.8	1.1	4.6	-0.2	-1.3	-1.3	-1.7	-2.1	-1.3	-1.0	0.4	0.6	0.0	-0.8	0.1	-0.4	-1.0	-0.4	1.3
Hypothyroidism (self reported)	0.8	1.8	4.4	1.5	-0.8	-0.9	-1.7	-1.7	-2.1	-1.4	0.8	-1.2	-1.2	0.2	-1.2	0.5	1.8	-2.1	-0.9
Angina	0.8	1.1	2.5	1.2	-1.3	-1.1	-1.4	-1.0	-1.4	-0.7	0.8	-0.0	-1.0	0.9	-1.6	0.7	1.1	0.0	-0.9
Impedance of leg (right)	0.8	3.7	19.9	-2.1	1.2	0.5	1.1	1.0	0.3	0.5	-2.0	-1.4	1.2	-4.5	-1.8	-2.4	0.1	-1.6	-3.3
Fed-up feelings	0.8	1.4	5.5	-1.1	0.3	0.3	0.2	-0.5	0.4	0.3	-1.3	2.4	1.0	-0.8	1.9	-0.8	-1.6	0.1	2.1
Heart attack	0.8	1.1	5.0	1.3	-0.5	0.2	0.2	0.9	0.5	-0.6	1.2	-0.4	-1.4	2.2	-0.3	1.5	1.6	0.8	0.1
Medication: Simvastatin	0.8	1.2	10.2	0.0	0.7	0.6	0.4	-0.2	-0.1	0.7	0.1	3.2	0.2	-0.2	0.9	0.5	-0.8	1.3	2.1
Impedance of arm (right)	0.8	3.5	22.2	-3.0	0.6	-0.0	0.7	0.1	0.1	0.3	-2.9	0.2	2.2	-4.7	0.0	-2.5	-1.4	-0.7	-1.4
Worrier / anxious feelings	0.8	1.5	4.5	-1.1	1.3	1.5	1.7	1.6	2.1	0.1	-1.9	0.3	1.3	-0.0	1.3	-0.6	-0.7	0.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.9	0.6	-0.9	-0.8	-1.4	-1.3	-1.6	-1.7	0.9	-0.7	-0.7	-0.1	-0.6	0.1	1.0	-0.6	-0.7
Arm fat mass (right)	0.8	3.3	6.1	2.1	-2.3	-2.0	-2.3	-2.4	-2.1	-1.1	1.9	1.7	-1.7	2.5	0.6	1.7	0.4	0.5	1.8
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.6	0.3	0.7	1.5	1.3	1.6	1.3	-0.3	-0.7	-1.6	0.1	1.0	-1.0	0.7	0.6	0.3	-0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.1	1.3	-0.7	-0.8	-1.4	-1.4	-1.8	-1.2	0.9	-1.2	-0.9	0.4	-1.7	0.5	1.3	-1.6	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.5	0.9	-0.9	-0.6	-1.1	-0.9	-0.9	0.1	1.9	1.0	-1.0	1.1	0.6	1.3	0.3	0.6	1.3
Qualifications: College or University degree	0.8	2.4	11.8	-1.0	-1.4	-1.2	-0.8	-0.7	-0.3	-3.0	-2.5	-3.4	1.6	-0.3	0.4	-1.1	-0.6	-1.2	-0.5
Pulse rate, automated reading	0.8	2.4	6.7	1.7	-2.6	-2.2	-2.6	-2.2	-2.4	-0.8	1.5	0.7	-1.0	1.0	0.1	1.2	0.8	-0.4	0.1
Overall health rating	0.8	1.8	4.2	2.1	-1.3	-1.1	-1.2	-1.0	-1.1	-1.3	1.6	0.4	-1.5	1.8	-0.8	2.0	1.5	0.8	0.2
Hypertension (Self-reported)	0.8	2.1	8.4	2.7	-1.2	-0.1	-0.8	-0.1	-0.3	-0.5	1.4	-0.0	-1.9	2.9	-1.0	2.1	1.9	0.7	-0.7
Illnesses of father: Heart disease	0.8	1.1	4.2	1.6	-0.6	-0.1	-0.6	-0.1	-0.1	-0.0	1.4	-0.2	-1.6	2.0	-0.3	1.5	1.1	1.3	0.1
Ever had bowel cancer screening	0.8	0.9	2.5	0.3	-1.4	-1.3	-1.2	-1.3	-0.8	-1.3	0.4	1.0	0.2	0.8	0.4	1.1	-0.3	0.4	1.6
Medication for cholesterol	0.8	1.2	4.6	-1.9	0.3	-0.1	0.2	0.1	0.1	0.1	-1.1	-0.8	1.7	-2.1	0.5	-1.6	-1.1	-1.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.4	-0.4	0.8	1.5	1.3	1.5	1.6	0.9	-1.2	0.5	0.6	0.6	1.1	-0.4	0.0	0.6	0.2
Arm fat mass (left)	0.8	3.4	6.3	2.1	-2.4	-2.1	-2.5	-2.5	-2.2	-1.2	1.8	1.8	-1.7	2.4	0.4	1.6	0.4	0.4	1.8
Number of operations (self-reported)	0.8	1.2	4.9	-0.3	0.4	0.2	0.6	0.4	0.7	-1.0	0.6	1.8	1.1	0.7	1.6	0.9	-0.6	1.7	2.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	1.0	-1.3	-1.2	-1.1	-0.5	-0.5	0.8	1.4	0.7	-1.5	1.4	-0.7	0.9	0.3	1.0	0.4
Worry (Nagel 2018)	0.7	1.5	4.5	-0.6	0.8	0.6	1.1	1.1	1.6	1.2	-0.0	1.8	0.5	0.6	1.9	0.7	-0.8	1.5	2.1
Ulcerative Colitis	0.7	0.9	3.2	0.1	-1.8	-1.4	-1.7	-1.6	-1.5	-1.3	0.1	0.5	0.1	-0.0	0.3	-0.1	-0.2	-0.5	0.3
Trunk fat percentage	0.7	2.6	7.0	1.4	-2.5	-2.3	-2.5	-2.6	-2.7	-1.3	1.1	1.4	-1.3	0.4	-0.4	0.5	0.6	-0.7	0.2
Relative age voice broke	0.7	1.0	3.8	-1.1	-0.4	-0.5	-0.3	-0.6	-0.5	-1.0	-1.9	-1.1	1.4	-0.8	-0.0	-1.3	-1.0	-1.8	-0.1
Hearing difficulty/problems with background noise	0.7	1.2	6.1	1.5	-0.6	0.2	0.3	0.7	0.7	-0.6	0.9	-0.9	-1.1	2.5	-0.3	1.8	1.2	1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.5	1.8	-1.3	-0.8	-1.1	-0.7	-0.9	-1.3	0.6	-1.6	-0.8	1.7	-1.9	1.6	1.2	1.0	-1.0
Impedance of arm (left)	0.7	3.4	23.0	-2.9	0.8	0.2	0.9	0.4	0.3	0.8	-2.6	0.4	1.9	-4.8	-0.1	-2.5	-1.1	-0.8	-1.6
Peak expiratory flow (PEF)	0.7	1.7	4.5	0.1	1.6	2.1	1.6	2.1	1.6	1.4	-0.4	-1.7	-1.2	1.5	-0.6	-0.3	0.6	-0.2	-1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.1	-1.0	-0.8	-1.0	-0.7	-0.8	-0.8	-0.7	-1.2	-1.8	0.8	-1.5	-0.7	-1.4	-0.5	-1.3	-1.7
Medication: Amlodipine	0.7	1.0	3.7	1.3	-0.5	-0.5	-0.4	-0.2	0.1	0.2	1.0	0.6	-1.2	1.9	1.4	1.1	0.7	1.2	1.4
Number of children fathered	0.7	0.8	3.9	0.8	-0.3	-0.2	-0.1	0.2	-0.2	-0.0	0.4	-2.0	-0.6	0.7	-1.8	0.7	0.6	-0.4	-1.7
Neck or shoulder pain in last month	0.7	0.9	4.1	0.5	-0.3	-0.5	-0.9	-1.1	-1.0	-0.7	1.5	2.0	-0.8	-0.2	0.2	1.0	0.2	1.0	1.1
Angina (self-reported)	0.7	0.9	2.4	1.0	-1.2	-1.1	-1.2	-0.9	-1.2	-0.6	0.7	-0.0	-0.9	0.6	-1.5	0.6	1.1	0.1	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	3.3	-0.2	1.5	1.8	1.2	1.3	1.4	0.7	-0.1	0.1	0.5	0.7	0.1	0.1	-0.1	0.6	0.6
Leg fat mass (right)	0.7	2.6	4.5	2.0	-1.9	-1.8	-2.1	-2.1	-2.1	-0.9	1.8	1.5	-1.6	2.1	-0.1	1.4	0.6	0.3	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.5	-0.9	1.1	1.1	1.3	1.4	1.6	0.8	-0.9	1.1	0.2	-0.1	0.6	-0.3	-0.6	0.5	0.6
Average weekly red wine intake	0.7	1.1	3.9	-0.7	0.0	0.2	0.4	0.4	0.1	-1.9	-2.0	-1.0	1.3	-0.4	1.3	-1.5	-0.8	-1.0	-0.4
Risk taking	0.7	1.0	5.0	0.8	-0.9	-0.1	-0.5	-0.2	0.2	-0.4	-0.1	-2.2	-1.2	1.9	-1.6	0.6	0.8	-0.5	-0.7
Cholesterol lowering medication	0.7	1.0	4.6	0.9	0.1	0.4	-0.0	-0.2	-0.1	0.6	1.0	2.1	0.0	0.7	-0.2	1.6	0.2	2.1	1.0
Depression (Nagel 2018)	0.6	0.9	3.9	0.5	-0.5	0.2	-0.1	-0.2	0.6	-0.6	1.1	0.9	-0.3	1.7	0.7	1.5	-0.0	1.0	2.0
Reaction Time	0.6	1.2	5.0	-1.6	0.5	0.0	0.9	0.5	1.0	1.5	-0.3	1.2	1.3	-0.9	0.2	-0.2	-2.2	1.0	1.6
Bipolar Disorder (2011)	0.6	0.5	2.4	-0.2	0.5	0.8	0.9	1.2	1.6	1.3	0.3	0.4	0.4	0.5	0.6	0.3	0.1	0.3	0.3
HDL Cholesterol	0.6	1.1	5.0	0.1	-0.6	-1.0	-0.6	-0.8	-0.9	1.4	0.7	2.2	-1.5	-0.0	0.8	0.3	-0.2	-0.4	1.8
Triglycerides	0.6	1.0	1.9	-0.9	1.3	1.3	1.0	1.3	0.9	0.7	-0.8	-1.1	1.3	-0.4	0.1	-1.0	-0.4	0.4	-1.4
Neuroticism	0.6	1.4	5.6	-0.7	1.1	1.0	1.1	0.5	1.6	0.6	0.1	2.2	0.7	0.0	1.8	0.1	-1.1	0.2	2.4
Vitamin and mineral supplements	0.6	0.8	2.0	0.7	-0.9	-1.4	-1.2	-1.1	-1.3	-1.2	0.6	-0.3	0.4	-1.4	-0.7	-0.1	0.3	-0.3	-0.9
Supplements: Zinc	0.6	0.6	2.8	0.8	0.4	1.6	0.2	0.4	0.7	-0.2	-0.2	-1.7	-0.1	1.1	-0.7	0.0	0.8	-0.6	-0.5
Diabetes (mother)	0.6	0.7	2.3	1.5	-0.9	-0.3	-0.9	-0.7	-0.9	-1.3	0.2	-0.2	-0.9	1.2	0.1	0.1	1.3	-0.7	-0.6
Severe depression (siblings)	0.6	0.6	2.9	-0.8	-0.0	-0.2	0.4	0.7	0.1	-0.4	-1.4	0.5	1.7	-0.3	1.1	-1.0	-0.5	-0.8	-0.8
High blood pressure (mother)	0.6	0.8	1.8	0.6	-1.4	-1.2	-1.1	-0.9	-1.2	-0.9	0.7	0.7	-0.2	0.6	1.3	0.3	-0.4	0.7	0.8
Hair/balding pattern: Pattern 3	0.6	0.8	2.0	-0.4	-0.2	-0.6	-1.0	-1.4	-1.2	-1.1	0.6	0.7	1.0	-1.3	1.2	-0.3	-0.7	-0.9	1.0
Depression (self-reported)	0.6	0.7	4.2	-0.8	0.2	0.0	0.1	-0.4	-0.1	1.2	-0.1	2.1	0.3	-1.2	0.8	-0.3	-0.8	0.4	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	2.4	1.1	-0.4	-0.3	-0.2	-0.5	-0.5	-0.1	1.3	1.4	-0.4	1.2	-0.1	1.6	0.5	0.9	1.0
Blood clot in the leg (DVT)	0.6	0.8	1.6	0.6	-1.1	-1.0	-1.0	-0.6	-0.3	0.7	1.3	0.9	-1.0	1.2	-0.4	0.8	-0.2	1.1	0.9
Eye problems/disorders: None of the above	0.6	0.7	2.7	1.1	-1.3	-1.0	-0.7	-0.4	-0.7	-0.3	0.8	-0.7	-1.0	1.6	-0.2	0.8	0.8	0.1	-0.0
Medication: Ibuprofen	0.6	0.7	2.7	0.5	-1.0	-0.9	-1.0	-0.5	-1.0	-0.6	0.7	-1.0	-0.4	-0.0	-1.6	0.6	0.8	0.2	-1.1
Had major operations	0.6	0.7	2.7	-0.4	0.9	0.8	0.9	0.8	0.8	-0.5	0.3	0.5	0.9	0.4	1.6	1.0	-0.1	0.9	1.3
Qualifications: nursing, teaching	0.6	0.9	3.9	-1.0	-0.2	-0.1	-0.4	-0.8	-0.6	-0.8	-2.0	0.1	1.3	-0.9	1.4	-1.1	-1.0	-0.7	0.8
Breast cancer (self-reported)	0.6	0.7	2.5	-0.9	0.0	0.0	-0.1	-0.4	-0.2	-0.1	-1.6	1.3	1.5	-1.2	0.6	-0.9	-1.0	0.5	0.3
Ever taken oral contraceptive pill	0.6	0.6	1.5	0.6	-1.2	-0.7	-1.2	-0.9	-0.9	-0.6	0.2	0.2	-0.4	1.0	0.8	0.9	0.1	0.7	1.0
Financial situation satisfaction	0.6	0.7	3.6	0.9	-0.3	0.2	-0.2	-0.1	-0.0	-1.2	0.7	-1.9	-0.8	1.1	-1.2	0.6	1.0	-0.6	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.7	3.4	0.8	0.4	0.6	0.2	0.1	0.5	-0.1	0.9	0.5	-0.5	1.0	-1.2	1.9	0.5	1.6	0.4
Medication: Bendroflumethiazide	0.6	0.9	3.9	1.2	-0.7	0.0	-0.3	-0.2	0.3	0.0	1.0	0.6	-1.3	2.0	0.0	1.5	0.6	1.3	1.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.9	-0.6	1.2	1.4	1.1	1.3	1.2	0.8	-0.1	0.7	0.5	0.7	-0.4	0.2	-0.5	0.9	0.4
Pain experienced in last month	0.6	1.0	3.9	-0.8	0.9	0.4	1.0	1.0	0.5	0.1	-2.0	-1.2	1.6	-0.2	0.7	-1.4	-0.5	-0.9	-0.8
Basal cell carcinoma (self-reported)	0.6	0.8	2.2	0.6	1.1	1.5	0.9	0.7	0.7	-0.0	-0.4	-0.9	-0.7	0.2	-1.1	0.1	1.1	-0.8	-1.3
Alcohol drinker status: Previous	0.6	0.7	2.2	0.2	0.3	-0.0	0.5	0.7	0.7	1.2	1.5	0.9	-0.9	0.1	0.7	1.3	0.8	1.0	0.8
Leg fat mass (left)	0.6	2.2	4.1	1.9	-1.6	-1.5	-1.8	-1.8	-1.8	-0.6	1.7	1.7	-1.6	2.0	-0.1	1.4	0.5	0.3	1.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.9	-1.3	1.1	1.5	0.7	0.8	0.9	-0.7	-2.0	-1.3	2.4	-1.7	0.5	-1.6	-0.5	-0.9	-0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	2.8	-0.5	-0.8	-1.0	-0.7	-0.8	-0.5	-1.1	-0.3	0.9	0.6	-0.2	0.9	-0.1	-0.9	0.6	1.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.5	-1.3	0.7	1.1	0.4	0.2	0.6	-0.3	-1.9	-1.6	1.6	-1.4	-0.5	-1.3	-0.6	-1.0	-1.4
Body Mass Index (BMI) (2010)	0.5	0.7	2.7	-0.1	1.0	0.9	1.4	1.6	1.3	0.6	-0.8	-0.8	0.5	0.3	-0.6	-0.0	0.1	0.1	-0.9
Waist Hip Ratio (WHR)	0.5	2.4	6.1	2.5	-1.6	-0.3	-1.4	-0.8	-0.9	-0.4	1.7	-1.6	-2.1	2.1	-0.8	1.7	2.1	-0.4	-1.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.3	1.1	0.1	0.6	-0.2	0.1	0.3	1.2	1.5	1.3	-1.0	1.5	0.5	1.3	0.6	0.4	1.3
Number of treatments/medications taken	0.5	0.9	5.0	0.5	1.1	0.9	0.5	0.3	0.5	0.4	0.7	2.2	-0.6	0.1	0.0	1.2	0.6	1.3	1.5
Systolic blood pressure, automated reading	0.5	1.5	4.5	0.9	-1.2	-1.5	-1.5	-1.8	-2.1	-0.6	0.3	0.6	-0.9	-0.2	-1.4	-0.6	0.3	-2.1	-0.8
Medication: Metformin	0.5	0.7	3.1	0.8	0.2	0.5	0.1	0.6	0.2	1.8	1.3	0.8	-0.9	1.0	0.5	1.2	0.5	0.5	0.5
Diabetes (father)	0.5	0.6	1.6	1.0	-1.2	-1.1	-1.1	-0.9	-1.1	-0.9	0.5	-0.1	-0.7	1.0	-0.1	0.3	0.4	-0.5	0.0
Serious illness, injury or assault to yourself	0.5	0.6	1.4	1.0	-1.0	-0.7	-0.7	-0.4	-0.7	-0.9	-0.7	-1.2	-0.9	0.6	-0.9	0.2	0.8	-0.1	-0.9
Multivitamins +/- minerals	0.5	0.6	2.3	-0.3	0.6	0.7	0.9	0.8	0.8	0.7	-0.5	0.1	-0.7	1.5	0.2	0.7	-0.0	1.1	1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.0	0.5	0.5	0.5	0.8	0.9	1.0	0.9	1.1	-0.2	0.9	0.9	0.9	0.3	0.3	1.3
Chronic bronchitis/emphysema (father)	0.5	0.5	2.2	0.4	-0.4	-0.3	-0.5	-0.5	-0.1	-0.9	1.5	0.7	0.2	0.3	1.3	0.8	-0.3	0.7	1.1
Mouth/teeth dental problems	0.5	0.7	3.4	0.1	0.1	-0.4	-0.3	-0.5	-0.2	-0.1	1.0	0.5	0.5	-0.3	1.6	1.3	0.1	1.8	1.3
Weight	0.5	2.3	11.7	-0.6	0.2	0.2	0.2	-0.4	0.3	1.1	0.2	3.3	0.3	0.8	2.4	-0.1	-2.0	1.1	3.4
Happiness	0.5	0.6	3.0	-0.3	-0.1	0.6	0.7	0.8	1.1	-0.3	-0.6	-1.7	0.3	1.1	-1.0	-0.1	-0.4	-0.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.0	-0.0	-1.4	-1.1	-1.4	-1.3	-1.3	-2.2	-1.1	-0.8	0.8	0.0	1.3	0.3	0.3	0.1	0.8
Health satisfaction	0.5	0.7	1.8	0.5	1.2	1.4	1.2	1.2	1.3	-0.1	-0.0	-0.6	0.0	0.7	-0.4	0.8	0.5	0.6	-0.0
Mean time to correctly identify matches	0.5	0.9	2.7	-1.2	0.6	0.5	1.0	0.7	1.3	1.6	-0.3	1.0	0.7	-0.6	-0.1	0.0	-1.6	0.6	1.2
Alcohol intake frequency.	0.5	1.3	7.9	0.9	-0.6	-0.7	-0.4	-0.1	0.3	-0.2	2.8	1.2	-0.6	0.9	-0.1	2.0	0.8	1.1	1.2
Smoking status: Previous	0.5	0.7	2.7	-0.5	0.3	1.0	0.3	0.4	0.7	0.4	-0.9	-0.6	0.7	0.2	1.6	-1.1	-0.3	-1.5	-0.8
Diabetes diagnosed by doctor	0.5	0.9	4.5	0.5	-0.5	-0.0	-0.7	-0.6	-0.4	0.3	0.8	2.1	-0.2	0.6	1.5	0.7	-0.2	0.2	2.1
Eye problems/disorders: Glaucoma	0.5	0.6	3.3	-0.2	0.6	0.2	-0.3	-0.9	-0.5	-0.3	-0.2	1.8	0.1	-1.0	0.7	-0.1	-0.4	-0.8	1.6
Alcohol drinker status: Never	0.5	0.6	3.8	0.2	-0.8	-0.8	-0.5	-0.5	0.0	-0.7	0.5	0.7	0.0	0.7	0.3	1.1	-0.4	1.1	2.0
Average weekly beer plus cider intake	0.5	0.8	1.9	-1.1	0.9	1.1	1.0	0.8	1.4	0.9	-0.6	0.9	-0.2	-0.2	0.9	-0.5	-0.5	0.3	1.4
Unable to work because of sickness or disability	0.5	0.7	1.7	0.3	0.8	0.9	1.0	1.1	1.1	1.3	0.6	0.3	-0.8	0.8	-0.6	0.6	0.7	0.9	-0.3
Breast Cancer	0.4	1.0	2.5	1.2	-0.5	-0.7	-0.9	-0.9	-1.0	-1.6	1.5	0.1	0.3	1.3	0.3	1.3	0.5	0.9	1.0
Coronary Artery Disease (CAD)	0.4	0.5	2.0	0.3	0.9	1.0	0.6	0.5	0.5	1.4	0.3	0.2	-0.9	0.4	-0.4	0.9	0.8	-0.1	-0.7
Cardiovascular Disease	0.4	1.2	4.3	2.1	-0.3	0.7	-0.4	-0.4	-0.3	-0.5	1.2	1.3	-1.0	2.0	0.2	1.6	1.3	0.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	-0.4	0.0	0.3	-0.0	-0.3	-0.2	-1.0	-1.3	1.1	0.6	-0.5	0.5	-1.0	-0.6	-0.8	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	-0.6	0.6	0.9	0.5	0.3	0.9	0.8	0.0	1.0	0.2	-1.0	0.7	-0.0	-0.4	0.6	1.0
Trunk fat mass	0.4	1.5	6.8	0.4	-1.4	-1.4	-1.5	-1.9	-1.6	-0.2	0.5	2.6	-0.4	0.1	0.9	0.0	-0.8	-0.0	1.7
Past tobacco smoking	0.4	0.7	6.4	-0.1	0.2	-0.6	0.3	0.3	0.0	0.5	0.5	0.6	-0.1	-0.0	-1.3	1.0	-0.4	2.5	1.1
Had other major operations	0.4	0.5	1.4	-0.6	1.2	1.0	1.2	0.8	1.1	0.1	-0.4	0.6	0.6	0.3	-0.2	0.1	-0.4	0.6	0.6
Pain all over the body in last month	0.4	0.5	1.2	-0.7	0.4	0.7	0.7	0.8	0.9	1.1	-1.0	-0.2	-0.3	-0.2	-0.3	-0.8	0.2	-1.1	-0.2
Alcohol intake versus 10 years previously	0.4	0.5	1.6	0.0	0.2	0.1	-0.0	-0.3	0.8	0.7	1.2	1.2	-0.4	0.7	0.1	1.2	0.2	0.8	1.3
Medication: Cholesterol lowering	0.4	0.6	3.1	0.0	1.1	0.9	1.0	0.8	0.5	0.6	-0.2	1.8	-0.4	0.4	0.3	0.0	-0.3	0.6	1.2
Breastfed as a baby	0.4	0.5	2.0	0.4	-0.1	-0.4	0.1	0.8	-0.4	-1.0	-0.4	-1.4	0.7	0.4	-0.3	0.2	0.9	-0.4	-1.4
Medication: Paracetamol	0.4	0.7	3.6	1.0	0.1	0.3	-0.6	-0.4	-0.3	0.8	1.9	0.3	-1.1	0.2	-1.5	0.8	0.9	-0.0	-0.8
Gout (self-reported)	0.4	0.5	1.5	0.7	0.8	1.2	0.7	0.8	1.0	0.2	0.5	-0.0	-0.3	0.7	-0.2	1.0	0.6	0.9	0.7
Worry too long after embarrassment	0.4	0.7	3.2	1.2	-0.5	-0.3	-0.4	-0.3	-0.1	-0.6	0.7	0.6	-0.4	1.8	0.7	1.3	0.6	0.1	1.2
Whole body fat mass	0.4	1.8	5.3	0.9	-1.7	-1.6	-1.8	-2.1	-1.8	-0.6	1.1	2.3	-1.0	0.9	0.6	0.4	-0.3	-0.1	1.7
Loneliness, isolation	0.4	0.5	1.6	0.6	-1.1	-0.9	-0.4	-0.5	-0.3	-0.5	0.5	0.6	-0.7	1.2	0.1	0.8	0.1	0.1	1.3
Long-standing illness, disability or infirmity	0.4	0.6	2.0	0.9	0.6	0.7	0.6	0.6	0.6	0.6	-0.0	0.5	-0.9	1.1	-0.3	1.4	0.7	0.8	0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.4	-0.7	-0.7	-1.1	-0.2	-0.1	-0.7	-0.7	-0.9	-1.1	0.5	-0.8	-0.8	-1.1	-0.5	-0.4	-1.2
Commuting to job workplace: Public transport	0.4	0.5	1.9	-0.8	0.0	-0.4	-0.1	-0.6	-0.6	-1.3	-1.4	-0.6	0.4	-0.9	-0.1	-0.9	-0.3	-0.9	0.0
Medication: Paracetamol	0.4	0.6	2.3	0.2	0.9	0.9	0.4	0.4	0.4	1.5	1.3	0.8	-0.7	-0.1	-1.2	0.1	0.2	0.2	-0.5
Medication: Atorvastatin	0.4	0.5	1.5	-0.4	0.6	0.8	0.8	0.7	1.1	1.2	-0.3	0.4	-0.1	-0.2	-0.7	0.2	-0.3	1.2	0.1
Ever smoked	0.4	0.7	5.8	0.1	0.1	0.5	-0.4	-0.6	-0.4	-0.9	-0.2	-0.3	0.1	-0.7	0.2	-0.9	0.5	-2.4	-1.3
Bipolar Disorder (2018)	0.3	0.5	1.6	-0.4	0.4	0.9	0.6	0.6	1.1	0.8	0.8	0.8	0.8	-0.2	1.3	0.4	-0.3	0.6	0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.2	0.4	-0.5	-0.3	-0.2	-0.3	-0.3	0.4	-0.3	-0.8	-1.0	0.3	-0.6	0.1	0.6	-1.1	-0.7
Systolic Blood Pressure	0.3	1.6	4.0	2.0	-1.3	-1.4	-1.1	-0.8	-1.4	-0.4	1.0	0.3	-2.0	1.5	-1.1	1.3	1.6	0.8	-0.6
Sensitivity / hurt feelings	0.3	0.4	1.9	-0.4	0.6	-0.0	0.8	0.5	0.2	-0.2	-0.9	1.4	1.1	-0.6	0.8	-0.5	-0.5	0.0	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.6	-0.1	0.6	0.8	1.0	0.8	1.2	-0.3	-0.4	-0.4	0.2	1.0	-0.0	0.3	-0.0	-0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	2.3	-0.1	0.4	0.7	0.5	0.3	1.1	-0.0	0.2	0.9	0.4	0.8	0.6	0.5	-0.5	0.6	1.5
Stomach or abdominal pain in last month	0.3	0.4	1.5	0.6	-0.2	-0.2	-0.2	-0.2	-0.1	0.1	0.5	1.2	-0.4	0.4	0.2	1.2	0.3	1.2	0.9
Nervous feelings	0.3	0.6	2.7	-0.3	0.6	0.4	1.0	1.2	1.2	1.6	-0.0	0.5	0.1	0.6	0.0	0.5	-0.5	1.2	0.7
Hip circumference	0.3	1.2	3.5	0.3	-1.5	-1.5	-1.3	-1.4	-1.2	-1.0	0.2	1.3	-0.1	1.0	0.6	-0.2	-1.1	-0.1	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	0.9	-1.1	-0.5	-0.3	-0.2	0.0	-0.9	-0.1	-0.1	-1.2	1.4	0.1	0.4	0.7	-0.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.1	-0.5	1.6	1.8	1.2	1.2	1.3	1.0	-0.6	-0.7	-0.5	0.2	0.9	-0.7	-0.1	-0.1	0.1
Noisy workplace	0.3	0.3	1.4	-0.3	-0.1	-0.3	0.3	0.7	0.3	0.9	1.0	-0.3	-0.3	-0.2	-1.2	-0.2	-0.1	0.5	-0.8
Headache pain in last month	0.3	0.4	3.4	-0.5	0.0	-0.4	-0.3	-0.5	-0.5	-0.6	-0.5	0.1	0.9	-1.8	-0.1	-0.6	-0.2	-0.3	-0.8
Number of full brothers	0.3	0.3	1.6	0.2	0.7	0.3	0.9	1.0	0.2	-0.2	-0.5	-0.2	0.4	0.5	-0.2	0.2	0.2	1.3	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	-0.5	0.6	0.7	0.8	0.8	0.7	0.6	-0.8	1.4	0.6	0.5	0.7	0.1	-0.4	0.3	0.9
Age at first live birth	0.3	0.5	1.2	-0.9	0.9	0.2	1.0	0.7	0.8	-0.3	-0.7	-0.5	1.1	-0.8	0.6	-0.0	-0.5	1.0	0.6
Medication: Allopurinol	0.3	0.5	1.6	0.5	0.5	0.9	0.3	0.3	0.6	0.5	0.2	0.9	-0.2	1.0	-0.5	0.7	-0.3	1.3	1.0
Number of full sisters	0.3	0.3	0.9	-0.3	-0.7	-0.5	-0.9	-0.8	-0.4	0.8	0.5	0.2	0.3	0.4	0.6	0.5	-0.5	0.4	0.7
Age at last live birth	0.3	0.4	2.9	-0.7	0.5	-0.0	0.4	0.0	0.1	-0.3	-0.3	0.4	0.8	-1.2	0.0	0.3	-0.4	1.7	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.5	-0.5	0.6	0.4	0.5	0.1	0.3	0.8	0.4	1.6	-0.7	0.4	0.1	0.0	-0.5	-0.0	1.1
Supplements: Vitamin C	0.3	0.3	1.3	-0.3	0.9	1.1	0.8	0.8	0.8	0.4	-0.2	0.5	0.0	0.8	0.2	0.2	0.2	0.3	0.2
Knee pain experienced in last month	0.3	0.5	2.0	0.2	-0.0	0.3	-0.6	-0.9	-0.2	-0.4	1.4	1.4	-0.6	-0.4	0.3	0.4	-0.2	-0.2	1.4
Illnesses of siblings: Diabetes	0.3	0.4	1.9	1.0	-0.3	-0.1	-0.3	-0.1	-0.5	-0.3	0.5	-0.4	-0.8	1.4	-0.5	0.3	0.9	0.2	-0.3
Friendships satisfaction	0.3	0.4	1.5	-0.4	-0.2	0.3	0.0	0.1	0.7	-0.8	-0.5	-1.2	0.0	0.6	-1.0	0.4	-0.3	0.9	-0.6
Medication: Gliclazide	0.3	0.3	1.3	0.2	-0.4	-0.7	-0.2	-0.1	-0.0	0.2	0.9	1.0	-0.1	0.2	1.2	-0.2	-0.4	-0.3	1.1
Neuroticism (2016)	0.2	0.4	1.0	0.2	0.3	0.2	0.7	0.5	0.6	0.3	-0.3	1.0	-0.5	0.6	1.0	0.7	0.4	0.4	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	0.4	-0.2	-0.1	-0.0	0.2	0.3	0.3	0.1	0.7	-0.9	0.5	-0.1	0.9	-0.0	0.7	0.9
Townsend deprivation index at recruitment	0.2	0.2	0.8	0.7	-0.0	0.1	0.0	0.3	-0.1	0.4	0.6	-0.3	-0.6	0.6	-0.9	0.4	0.7	0.2	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.1	-0.5	-0.3	-0.5	-0.3	-0.5	0.2	0.8	0.7	0.5	0.3	0.4	0.0	-0.4	0.7	0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	-0.2	0.5	0.6	0.7	0.5	0.9	0.6	-0.0	0.8	-0.3	-0.1	0.7	0.3	0.3	0.5	0.7
Had menopause	0.2	0.3	0.9	-0.2	0.1	0.2	0.5	0.6	0.5	0.3	-0.6	0.1	0.7	-0.4	-0.9	-0.8	-0.5	-0.5	-0.9
Pulse rate	0.2	0.4	0.9	-0.1	-0.8	-0.7	-0.6	-0.6	-0.7	-0.7	-0.2	-0.4	0.7	-0.8	0.7	-0.4	0.1	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.5	-0.6	1.2	1.6	1.0	0.9	1.2	0.4	-0.7	-0.9	-0.4	0.2	1.3	-0.5	-0.3	-0.2	0.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	0.2	-0.9	-1.2	-0.8	-0.7	-0.9	-0.5	0.5	0.9	0.2	0.6	0.2	0.4	-0.6	0.8	0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	-0.3	0.3	0.9	0.4	0.4	0.6	-0.0	-0.7	-0.3	0.3	0.1	0.5	-0.8	-0.7	-0.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.8	0.2	-0.7	-0.2	-0.3	-0.3	-0.1	-0.5	-0.3	-0.1	0.0	0.3	-0.2	-0.2	-0.2	-1.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-0.6	0.1	-0.3	-0.0	-0.1	0.1	-0.2	-0.4	-0.9	0.9	-0.9	-0.1	-0.5	-0.3	-0.7	-0.9
Back pain experienced in last month	0.2	0.3	1.2	-0.8	-0.2	-0.0	-0.2	-0.4	-0.2	0.4	-0.4	0.4	0.5	-1.1	0.2	-1.0	-0.9	-0.7	0.0
Osteoporosis (self-reported)	0.2	0.3	1.3	-0.2	0.3	0.5	0.3	0.2	0.1	-0.2	-0.7	-0.5	1.0	-0.3	0.5	-0.6	-0.2	-1.1	-0.5
Age started oral contraceptive pill	0.2	0.2	1.6	-0.4	0.2	0.0	0.4	0.2	0.5	0.1	-0.7	-0.0	0.4	-0.3	-1.3	-0.1	-0.1	-0.4	-0.5
Myopia	0.2	0.3	0.9	0.5	-0.4	-0.1	-0.3	-0.3	-0.2	-1.0	0.7	-0.6	-0.7	0.6	-0.5	0.7	0.9	-0.1	-0.3
Heart disease (siblings)	0.2	0.2	1.0	0.4	0.2	0.2	-0.2	0.1	-0.2	0.2	0.7	0.6	-0.6	-0.1	-1.0	0.0	0.4	0.7	-0.5
Lung FVC	0.1	0.3	1.1	0.1	0.7	0.8	0.1	-0.1	0.2	-1.0	-0.6	-0.4	0.0	-0.6	0.7	-0.3	0.6	-0.7	-0.3
Lung cancer (father)	0.1	0.1	0.5	-0.4	0.4	0.1	0.3	-0.0	0.3	-0.1	0.2	0.1	0.3	0.1	0.1	0.4	-0.1	0.7	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.6	-0.2	-0.5	-0.7	-0.2	-0.2	-0.1	-0.1	-0.1	0.3	-0.4	-0.4	-0.5	-0.2	-0.1	-0.6	-0.3
Hair Pigment	0.0	0.8	2.8	-0.7	0.3	0.3	0.1	-0.5	0.0	-1.0	-1.7	-0.6	0.4	-1.5	0.3	-1.5	-0.8	-1.2	0.4
Tanning	0.0	0.3	1.0	0.7	-0.3	-0.1	-0.5	-0.5	-0.8	-1.0	-0.0	0.3	-0.3	0.7	0.3	0.7	0.5	-0.2	0.3

Hub : Genes

FAM69A

Models

Trait associations