Hub : Genes

FAM69A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0980 0.0320 2.2e-13 0.132 0.120 0.134 0.121 0.140 8.8e-16 2.0e-14 5.6e-16 1.4e-14 1.2e-16
2 GTEx Adipose Subcutaneous 0.0760 0.0360 5.7e-04 0.059 NA 0.026 NA 0.039 1.3e-05 NA 3.2e-03 NA 3.8e-04
3 GTEx Artery Aorta 0.3380 0.0770 4.6e-10 0.219 NA 0.236 NA 0.269 2.7e-12 NA 3.0e-13 NA 3.9e-15
4 GTEx Artery Coronary 0.2480 0.0960 2.5e-04 0.249 NA 0.179 NA 0.257 6.4e-09 NA 1.2e-06 NA 3.4e-09
5 GTEx Artery Tibial 0.3536 0.0622 0.0e+00 0.337 NA 0.358 NA 0.356 3.0e-27 NA 3.6e-29 NA 5.3e-29
6 GTEx Cells Transformed fibroblasts 0.2350 0.0590 1.7e-11 0.186 NA 0.165 NA 0.174 6.1e-14 NA 2.2e-12 NA 4.9e-13
7 GTEx Nerve Tibial 0.1705 0.0518 7.2e-07 0.029 NA 0.052 NA 0.046 3.5e-03 NA 1.4e-04 NA 3.2e-04
8 GTEx Pancreas 0.1000 0.0560 6.7e-03 0.082 NA 0.037 NA 0.035 2.4e-04 NA 1.1e-02 NA 1.2e-02
9 GTEx Thyroid 0.4280 0.0810 1.2e-09 0.180 NA 0.197 NA 0.184 9.5e-14 NA 5.5e-15 NA 5.2e-14
10 METSIM Adipose 0.0302 0.0172 1.8e-03 0.025 0.015 0.014 0.016 0.015 9.6e-05 1.8e-03 3.2e-03 1.7e-03 2.3e-03
11 ROSMAP Brain Pre-frontal Cortex 0.0962 0.0323 1.2e-13 0.129 0.109 0.137 0.128 0.154 2.6e-16 8.2e-14 3.6e-17 4.3e-16 2.4e-19
12 YFS Blood 0.2820 0.0545 0.0e+00 0.092 0.121 0.129 0.123 0.117 1.4e-28 1.8e-37 4.9e-40 5.5e-38 4.2e-36
13 TCGA Colon Adenocarcinoma 0.0510 0.0400 5.8e-03 0.006 0.016 0.017 NA 0.008 1.3e-01 4.0e-02 3.6e-02 NA 1.0e-01
14 TCGA Head and Neck Squamous Cell Carcinoma 0.0505 0.0261 1.4e-05 0.029 0.048 0.046 NA 0.042 3.1e-04 4.4e-06 6.8e-06 NA 1.6e-05
15 TCGA Kidney Renal Clear Cell Carcinoma 0.1882 0.0830 1.0e-03 -0.002 0.008 0.019 NA 0.007 8.0e-01 3.5e-02 3.0e-03 NA 4.8e-02
16 TCGA Thyroid Carcinoma 0.2500 0.1250 4.9e-04 0.063 0.009 0.044 NA 0.050 8.6e-07 4.5e-02 3.8e-05 NA 1.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.3 0.5 1.6 -0.4 0.4 0.9 0.6 0.6 1.1 0.8 0.8 0.8 0.8 -0.2 1.3 0.4 -0.3 0.6 0.8
Bipolar Disorder or Schizophrenia 1.5 3.6 6.4 -2.1 2.3 2.3 2.4 1.9 2.5 2.3 -1.3 1.6 1.8 -1.8 2.5 -1.2 -1.2 0.6 1.1
Depressed Affect (Nagel 2018) 1.2 2.6 12.5 -1.4 0.5 0.8 0.4 -0.2 1.1 0.8 -0.4 3.5 1.4 -0.7 2.4 -0.7 -2.3 0.1 3.1
Depression (Nagel 2018) 0.6 0.9 3.9 0.5 -0.5 0.2 -0.1 -0.2 0.6 -0.6 1.1 0.9 -0.3 1.7 0.7 1.5 -0.0 1.0 2.0
Intelligence (Savage-Jansen 2018) 0.5 1.6 5.9 -1.3 1.1 1.5 0.7 0.8 0.9 -0.7 -2.0 -1.3 2.4 -1.7 0.5 -1.6 -0.5 -0.9 -0.7
Neuroticism (Nagel 2018) 0.8 2.0 9.3 -1.0 0.3 0.2 0.3 -0.2 1.0 0.1 -0.4 2.9 1.3 0.1 2.4 0.2 -1.7 1.0 3.1
Schizophrenia (2018) 2.0 4.1 6.7 -2.4 2.6 2.3 2.6 2.0 2.3 2.4 -2.2 1.5 1.6 -2.1 2.2 -1.9 -1.3 0.3 0.8
Schizophrenia vs Biploar Disorder 0.9 1.1 3.1 -1.2 1.8 1.1 1.4 1.3 0.9 1.2 -1.1 0.6 1.0 -0.9 0.5 -1.0 -0.8 1.1 0.1
Worry (Nagel 2018) 0.7 1.5 4.5 -0.6 0.8 0.6 1.1 1.1 1.6 1.2 -0.0 1.8 0.5 0.6 1.9 0.7 -0.8 1.5 2.1
Alzheimer’s Disease (in mother) 1.0 1.2 3.1 -1.7 0.3 0.1 0.5 0.1 0.6 -0.1 -1.4 1.6 1.1 -1.1 1.6 -0.9 -1.3 -0.1 1.8
Alzheimer’s Disease (in father) 1.2 1.3 4.0 0.4 -1.7 -1.6 -2.0 -1.9 -1.8 -1.5 -0.1 0.3 0.2 -0.2 0.4 -0.1 -0.6 -0.3 0.9
Alzheimer’s Disease (including proxy) 0.5 0.7 2.8 -0.5 -0.8 -1.0 -0.7 -0.8 -0.5 -1.1 -0.3 0.9 0.6 -0.2 0.9 -0.1 -0.9 0.6 1.7
Crohns Disease (2017) 1.2 2.5 9.1 -1.6 -2.0 -3.0 -1.2 -1.1 -1.8 -1.4 -1.5 -0.4 1.1 -2.0 0.4 -1.7 -1.4 -2.0 -0.4
Irritable Bowel Disease (IBD) 1.4 3.4 12.3 -0.9 -3.0 -3.5 -2.1 -2.0 -2.3 -2.4 -1.4 -0.2 0.8 -1.1 0.7 -1.3 -1.1 -2.0 -0.2
Ulcerative Colitis (UC) 1.0 1.9 6.5 -0.2 -2.5 -2.5 -1.8 -1.8 -1.6 -2.2 -0.8 0.2 0.3 0.1 0.8 -0.4 -0.6 -1.1 0.4
Major Depression (MDD) 2.9 3.5 13.2 -1.3 2.3 1.9 3.0 3.1 2.5 3.6 -0.5 1.3 0.7 0.0 1.3 -0.7 -1.3 0.9 0.6
Reaction Time 0.6 1.2 5.0 -1.6 0.5 0.0 0.9 0.5 1.0 1.5 -0.3 1.2 1.3 -0.9 0.2 -0.2 -2.2 1.0 1.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.5 -1.3 0.7 1.1 0.4 0.2 0.6 -0.3 -1.9 -1.6 1.6 -1.4 -0.5 -1.3 -0.6 -1.0 -1.4
Breast Cancer 0.4 1.0 2.5 1.2 -0.5 -0.7 -0.9 -0.9 -1.0 -1.6 1.5 0.1 0.3 1.3 0.3 1.3 0.5 0.9 1.0
Ovarian Cancer 2.2 2.9 7.2 2.6 -1.2 -1.0 -1.0 -0.4 -1.5 -0.9 1.6 -1.9 -1.8 1.6 -2.5 1.6 2.7 -0.6 -2.2
Prostate Cancer 1.7 2.4 6.3 1.2 -2.0 -2.3 -2.2 -2.4 -2.5 -2.3 0.9 -1.1 -0.5 0.5 -1.3 0.2 -0.2 -1.3 -0.4
Age at First Birth 1.2 1.7 4.3 -2.0 0.8 0.6 1.3 0.8 1.5 0.7 -1.5 0.8 1.4 -0.0 1.8 -1.2 -2.1 -0.4 1.7
Bipolar Disorder (2011) 0.6 0.5 2.4 -0.2 0.5 0.8 0.9 1.2 1.6 1.3 0.3 0.4 0.4 0.5 0.6 0.3 0.1 0.3 0.3
Body Mass Index (BMI) (2010) 0.5 0.7 2.7 -0.1 1.0 0.9 1.4 1.6 1.3 0.6 -0.8 -0.8 0.5 0.3 -0.6 -0.0 0.1 0.1 -0.9
Coronary Artery Disease (CAD) 0.4 0.5 2.0 0.3 0.9 1.0 0.6 0.5 0.5 1.4 0.3 0.2 -0.9 0.4 -0.4 0.9 0.8 -0.1 -0.7
Crohns Disease (2012) 3.1 5.0 13.2 0.5 -3.5 -3.6 -3.1 -2.5 -3.4 -2.9 0.1 -1.9 -0.2 -0.7 -1.7 -0.4 0.8 -2.2 -2.5
Mean Putamen Volume 1.1 1.3 7.9 0.6 -1.1 -1.5 -0.8 -0.5 -0.9 -1.7 -0.1 -2.8 -0.1 0.7 -1.5 0.1 0.2 -0.4 -1.4
Fasting Glucose 1.0 1.2 4.7 -0.7 1.0 1.1 1.2 1.3 0.8 -0.1 -0.7 -0.8 0.7 -1.4 -0.4 -1.5 -0.0 -1.6 -2.2
HbA1C 1.4 1.5 6.1 1.5 -1.1 -1.1 -0.6 -0.1 -0.6 -0.6 0.2 -1.9 -1.4 1.6 -0.8 0.8 1.7 0.2 -2.5
HDL Cholesterol 0.6 1.1 5.0 0.1 -0.6 -1.0 -0.6 -0.8 -0.9 1.4 0.7 2.2 -1.5 -0.0 0.8 0.3 -0.2 -0.4 1.8
LDL Cholesterol 3.7 5.8 18.4 -3.8 2.9 1.9 2.4 1.7 2.2 2.7 -1.6 2.3 2.5 -4.3 0.9 -1.6 -2.5 1.5 0.8
Lupus 0.8 1.2 3.5 1.4 1.1 1.9 0.0 -0.4 0.1 -0.2 1.4 1.2 -1.7 0.4 -1.4 1.4 1.5 0.4 0.3
Neuroticism (2016) 0.2 0.4 1.0 0.2 0.3 0.2 0.7 0.5 0.6 0.3 -0.3 1.0 -0.5 0.6 1.0 0.7 0.4 0.4 1.0
Primary Biliary Cirrhosis 0.8 1.1 4.6 -0.2 -1.3 -1.3 -1.7 -2.1 -1.3 -1.0 0.4 0.6 0.0 -0.8 0.1 -0.4 -1.0 -0.4 1.3
Rheumatoid Arthritis 1.5 2.1 6.9 2.0 0.2 0.5 -0.6 -0.4 -1.2 0.6 2.0 -0.6 -1.8 0.1 -2.2 1.0 2.6 -0.5 -2.5
Schizophrenia (2014) 1.8 3.9 8.9 -1.9 2.9 2.5 3.0 2.8 2.6 2.9 -1.1 1.2 1.3 -1.4 1.5 -0.9 -0.7 1.0 0.5
Triglycerides 0.6 1.0 1.9 -0.9 1.3 1.3 1.0 1.3 0.9 0.7 -0.8 -1.1 1.3 -0.4 0.1 -1.0 -0.4 0.4 -1.4
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.2 0.4 -0.5 -0.3 -0.2 -0.3 -0.3 0.4 -0.3 -0.8 -1.0 0.3 -0.6 0.1 0.6 -1.1 -0.7
Ulcerative Colitis 0.7 0.9 3.2 0.1 -1.8 -1.4 -1.7 -1.6 -1.5 -1.3 0.1 0.5 0.1 -0.0 0.3 -0.1 -0.2 -0.5 0.3
Blood Eosinophil Count 0.9 7.2 23.3 0.2 -2.3 -2.2 -1.6 -1.9 -2.3 -3.5 -3.1 -4.8 0.2 0.5 -1.9 -3.1 -0.4 -4.8 -3.5
Blood Platelet Count 1.6 18.8 47.1 5.1 -4.1 -3.6 -3.0 -1.8 -3.0 -6.0 2.0 -6.9 -4.8 5.0 -5.9 2.5 4.8 -2.7 -4.1
Blood Red Count 1.2 12.0 32.9 5.1 -1.2 -1.0 -2.0 -1.4 -2.6 0.1 5.7 -1.0 -5.5 2.8 -5.1 4.0 5.0 1.1 -3.2
Blood White Count 2.9 21.7 38.1 5.8 -5.1 -4.5 -4.8 -4.0 -4.5 -5.3 4.6 -4.4 -5.0 6.2 -5.9 4.1 4.0 -1.4 -2.3
Heel T-Score 1.3 10.0 22.9 4.4 -3.2 -3.2 -2.5 -1.5 -2.4 -2.7 2.8 -3.4 -4.1 4.8 -3.7 3.6 3.3 0.4 -1.0
BMI 2.4 13.8 42.2 5.5 -4.5 -3.4 -4.0 -3.0 -3.3 -2.7 4.7 -1.2 -4.5 6.5 -1.8 3.9 3.3 -0.2 0.5
Height 4.7 90.1 174.2 -13.2 9.7 7.7 8.7 5.7 8.0 9.8 -7.7 11.6 9.6 -12.0 10.6 -9.3 -12.1 2.7 8.1
Waist Hip Ratio (WHR) 0.5 2.4 6.1 2.5 -1.6 -0.3 -1.4 -0.8 -0.9 -0.4 1.7 -1.6 -2.1 2.1 -0.8 1.7 2.1 -0.4 -1.5
Systolic Blood Pressure 0.3 1.6 4.0 2.0 -1.3 -1.4 -1.1 -0.8 -1.4 -0.4 1.0 0.3 -2.0 1.5 -1.1 1.3 1.6 0.8 -0.6
Smoking Status 0.9 2.1 4.4 1.4 -1.9 -1.4 -1.9 -1.8 -2.1 -2.1 0.3 -1.0 -1.1 1.1 -0.6 0.1 1.3 -1.9 -1.2
Allergy or Eczema 4.6 12.0 27.2 -4.6 3.8 3.7 4.1 3.8 4.2 2.1 -3.8 1.0 5.2 -2.6 3.4 -2.8 -4.1 1.5 1.3
Cardiovascular Disease 0.4 1.2 4.3 2.1 -0.3 0.7 -0.4 -0.4 -0.3 -0.5 1.2 1.3 -1.0 2.0 0.2 1.6 1.3 0.8 0.6
Hypothyroidism (self reported) 0.8 1.8 4.4 1.5 -0.8 -0.9 -1.7 -1.7 -2.1 -1.4 0.8 -1.2 -1.2 0.2 -1.2 0.5 1.8 -2.1 -0.9
Respiratory disease 2.6 5.8 13.1 -3.6 2.4 1.9 2.5 1.9 2.1 1.7 -2.7 1.6 3.6 -2.5 2.6 -2.5 -3.1 -0.4 1.3
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.3 1.1 0.1 0.6 -0.2 0.1 0.3 1.2 1.5 1.3 -1.0 1.5 0.5 1.3 0.6 0.4 1.3
Lung FEV1/FVC ratio 6.9 34.8 83.2 8.7 -4.8 -2.6 -3.6 -1.8 -2.8 -3.9 5.8 -6.4 -8.1 9.1 -6.5 7.5 8.5 -0.5 -4.0
Lung FVC 0.1 0.3 1.1 0.1 0.7 0.8 0.1 -0.1 0.2 -1.0 -0.6 -0.4 0.0 -0.6 0.7 -0.3 0.6 -0.7 -0.3
Neuroticism 0.6 1.4 5.6 -0.7 1.1 1.0 1.1 0.5 1.6 0.6 0.1 2.2 0.7 0.0 1.8 0.1 -1.1 0.2 2.4
Chronotype (morning person) 4.2 9.7 31.3 4.1 -2.4 -2.7 -2.5 -1.8 -2.2 -1.7 5.3 0.7 -3.6 2.8 -1.6 5.6 3.3 3.6 1.3
Hair Pigment 0.0 0.8 2.8 -0.7 0.3 0.3 0.1 -0.5 0.0 -1.0 -1.7 -0.6 0.4 -1.5 0.3 -1.5 -0.8 -1.2 0.4
Tanning 0.0 0.3 1.0 0.7 -0.3 -0.1 -0.5 -0.5 -0.8 -1.0 -0.0 0.3 -0.3 0.7 0.3 0.7 0.5 -0.2 0.3
Hand grip strength (left) 1.9 5.1 10.6 -3.2 2.9 2.3 2.5 2.0 2.6 2.2 -2.2 1.5 1.5 -1.7 1.6 -2.5 -3.1 0.1 2.0
Number of treatments/medications taken 0.5 0.9 5.0 0.5 1.1 0.9 0.5 0.3 0.5 0.4 0.7 2.2 -0.6 0.1 0.0 1.2 0.6 1.3 1.5
Average weekly spirits intake 1.0 1.2 3.2 -0.1 -0.9 -1.2 -0.8 -1.6 -0.9 -1.5 -0.5 1.7 -0.4 0.1 1.2 -0.7 -0.8 -1.3 1.8
Sensitivity / hurt feelings 0.3 0.4 1.9 -0.4 0.6 -0.0 0.8 0.5 0.2 -0.2 -0.9 1.4 1.1 -0.6 0.8 -0.5 -0.5 0.0 0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.6 -0.1 0.6 0.8 1.0 0.8 1.2 -0.3 -0.4 -0.4 0.2 1.0 -0.0 0.3 -0.0 -0.1 0.6
Hearing difficulty/problems: Yes 1.0 1.5 5.7 1.2 -1.5 -1.3 -1.2 -1.3 -0.9 -2.4 1.1 -1.6 -0.6 1.0 -1.1 0.8 0.8 -1.0 -0.3
Relative age of first facial hair 1.2 2.4 4.5 -1.6 2.0 1.9 2.1 2.0 1.9 1.6 -2.1 -0.9 1.8 -0.5 -0.2 -1.6 -1.0 -0.7 -1.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.6 -0.4 0.0 0.3 -0.0 -0.3 -0.2 -1.0 -1.3 1.1 0.6 -0.5 0.5 -1.0 -0.6 -0.8 0.5
Ever used hormone-replacement therapy (HRT) 1.5 2.0 8.1 -1.7 0.7 0.0 0.6 0.1 0.5 0.8 -0.8 2.8 1.3 -0.9 1.9 -0.4 -1.9 1.7 2.3
Ever had hysterectomy (womb removed) 1.1 1.3 3.3 0.8 1.2 1.2 1.1 1.7 0.9 0.9 1.8 -0.8 -0.7 0.7 -0.7 0.9 1.5 0.7 -1.4
Systolic blood pressure, automated reading 0.5 1.5 4.5 0.9 -1.2 -1.5 -1.5 -1.8 -2.1 -0.6 0.3 0.6 -0.9 -0.2 -1.4 -0.6 0.3 -2.1 -0.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.9 0.4 -0.2 -0.1 -0.0 0.2 0.3 0.3 0.1 0.7 -0.9 0.5 -0.1 0.9 -0.0 0.7 0.9
Angina 0.8 1.1 2.5 1.2 -1.3 -1.1 -1.4 -1.0 -1.4 -0.7 0.8 -0.0 -1.0 0.9 -1.6 0.7 1.1 0.0 -0.9
Medication for hormone replacement therapy 1.2 1.3 3.8 -1.5 0.8 0.3 0.9 0.7 0.7 0.2 -1.2 1.4 1.3 -0.2 1.5 -2.0 -1.9 0.2 1.1
Vitamin and mineral supplements 0.6 0.8 2.0 0.7 -0.9 -1.4 -1.2 -1.1 -1.3 -1.2 0.6 -0.3 0.4 -1.4 -0.7 -0.1 0.3 -0.3 -0.9
Supplements: Zinc 0.6 0.6 2.8 0.8 0.4 1.6 0.2 0.4 0.7 -0.2 -0.2 -1.7 -0.1 1.1 -0.7 0.0 0.8 -0.6 -0.5
Medication: Co-codamol 3.1 3.5 10.6 2.5 -0.1 -0.3 -0.6 -0.4 -0.8 0.0 3.0 0.1 -3.1 1.9 -2.2 3.2 3.0 1.5 -0.6
Medication: Metformin 0.5 0.7 3.1 0.8 0.2 0.5 0.1 0.6 0.2 1.8 1.3 0.8 -0.9 1.0 0.5 1.2 0.5 0.5 0.5
Diabetes (father) 0.5 0.6 1.6 1.0 -1.2 -1.1 -1.1 -0.9 -1.1 -0.9 0.5 -0.1 -0.7 1.0 -0.1 0.3 0.4 -0.5 0.0
Diabetes (mother) 0.6 0.7 2.3 1.5 -0.9 -0.3 -0.9 -0.7 -0.9 -1.3 0.2 -0.2 -0.9 1.2 0.1 0.1 1.3 -0.7 -0.6
Severe depression (siblings) 0.6 0.6 2.9 -0.8 -0.0 -0.2 0.4 0.7 0.1 -0.4 -1.4 0.5 1.7 -0.3 1.1 -1.0 -0.5 -0.8 -0.8
Pack years adult smoking proportion 2.1 3.3 8.2 2.5 -1.8 -1.7 -1.6 -1.1 -1.4 -0.8 2.3 -0.9 -2.9 2.3 -2.2 2.1 2.1 -0.0 -0.9
Impedance of leg (right) 0.8 3.7 19.9 -2.1 1.2 0.5 1.1 1.0 0.3 0.5 -2.0 -1.4 1.2 -4.5 -1.8 -2.4 0.1 -1.6 -3.3
Leg fat-free mass (left) 1.2 6.3 24.2 -2.3 1.5 1.3 1.4 0.4 1.6 2.4 -0.9 4.3 1.5 0.1 4.1 -1.0 -3.7 1.8 4.9
Trunk fat percentage 0.7 2.6 7.0 1.4 -2.5 -2.3 -2.5 -2.6 -2.7 -1.3 1.1 1.4 -1.3 0.4 -0.4 0.5 0.6 -0.7 0.2
Hand grip strength (right) 2.0 5.4 11.4 -3.0 3.1 2.5 2.7 2.6 2.7 3.4 -1.2 1.8 1.3 -1.7 1.6 -2.3 -2.9 1.0 1.6
Townsend deprivation index at recruitment 0.2 0.2 0.8 0.7 -0.0 0.1 0.0 0.3 -0.1 0.4 0.6 -0.3 -0.6 0.6 -0.9 0.4 0.7 0.2 -0.8
Current tobacco smoking 2.0 3.3 6.6 2.6 -1.8 -1.6 -1.8 -1.7 -2.0 -2.2 1.2 -1.2 -1.8 1.6 -2.4 1.8 2.4 -0.3 -1.5
Average weekly fortified wine intake 1.9 2.3 5.3 -1.6 -0.9 -1.4 -1.0 -1.6 -1.1 -1.5 -1.8 0.7 1.7 -2.3 0.7 -2.3 -1.8 -1.7 0.2
Maternal smoking around birth 1.7 2.4 9.2 1.4 -0.5 -0.2 -0.7 -0.5 -0.6 -0.9 0.8 -2.7 -1.3 1.4 -2.7 0.4 1.8 -1.6 -3.0
Fed-up feelings 0.8 1.4 5.5 -1.1 0.3 0.3 0.2 -0.5 0.4 0.3 -1.3 2.4 1.0 -0.8 1.9 -0.8 -1.6 0.1 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 2.3 -0.1 0.4 0.7 0.5 0.3 1.1 -0.0 0.2 0.9 0.4 0.8 0.6 0.5 -0.5 0.6 1.5
Relative age voice broke 0.7 1.0 3.8 -1.1 -0.4 -0.5 -0.3 -0.6 -0.5 -1.0 -1.9 -1.1 1.4 -0.8 -0.0 -1.3 -1.0 -1.8 -0.1
Taking other prescription medications 0.9 1.3 8.6 -0.6 1.1 1.1 0.3 0.0 0.1 1.4 0.1 2.9 1.0 -1.7 0.7 -0.0 -0.9 1.3 1.0
Age when periods started (menarche) 1.4 3.3 8.5 -2.4 1.4 1.3 1.1 0.5 1.6 0.9 -2.0 1.9 2.7 -1.7 1.9 -2.1 -2.9 0.1 2.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 0.1 -0.5 -0.3 -0.5 -0.3 -0.5 0.2 0.8 0.7 0.5 0.3 0.4 0.0 -0.4 0.7 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 6.7 2.3 -1.4 -1.0 -1.2 -0.7 -1.2 -1.4 0.6 -2.3 -1.0 1.7 -2.6 1.7 1.7 0.5 -1.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.1 -0.6 0.6 0.9 0.5 0.3 0.9 0.8 0.0 1.0 0.2 -1.0 0.7 -0.0 -0.4 0.6 1.0
Qualifications: CSEs or equivalent 0.9 1.2 2.8 1.6 -1.4 -0.8 -1.3 -1.0 -1.1 -0.6 1.4 -0.9 -1.7 0.5 -0.8 0.7 1.3 -0.5 -1.1
Serious illness, injury or assault to yourself 0.5 0.6 1.4 1.0 -1.0 -0.7 -0.7 -0.4 -0.7 -0.9 -0.7 -1.2 -0.9 0.6 -0.9 0.2 0.8 -0.1 -0.9
High blood pressure 0.9 2.6 11.2 2.9 -1.2 -0.1 -0.8 -0.0 -0.3 -0.5 1.7 0.1 -1.9 3.3 -1.0 2.6 2.0 0.9 -0.6
Hayfever, allergic rhinitis or eczema 4.3 9.2 24.4 -4.2 2.8 2.8 3.1 2.9 3.2 1.4 -3.5 1.1 4.9 -2.5 3.5 -2.8 -4.0 1.4 1.5
Multivitamins +/- minerals 0.5 0.6 2.3 -0.3 0.6 0.7 0.9 0.8 0.8 0.7 -0.5 0.1 -0.7 1.5 0.2 0.7 -0.0 1.1 1.2
Stomach or abdominal pain in last month 0.3 0.4 1.5 0.6 -0.2 -0.2 -0.2 -0.2 -0.1 0.1 0.5 1.2 -0.4 0.4 0.2 1.2 0.3 1.2 0.9
Supplements: Glucosamine 1.7 2.2 9.4 -2.2 1.0 0.9 0.8 0.1 1.2 0.7 -1.2 2.2 1.6 -0.8 1.6 -0.3 -2.1 1.0 3.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 0.0 0.5 0.5 0.5 0.8 0.9 1.0 0.9 1.1 -0.2 0.9 0.9 0.9 0.3 0.3 1.3
Medication: Atenolol 1.5 1.9 5.2 2.3 -1.7 -1.0 -1.6 -1.5 -1.4 -0.6 1.4 0.3 -1.8 1.8 -0.3 1.6 1.5 -0.3 0.5
Medication: Levothyroxine sodium 1.1 1.9 3.6 1.7 -0.9 -1.2 -1.5 -1.6 -1.6 -1.5 1.9 -0.2 -1.8 1.1 -1.5 1.6 1.7 -0.3 -0.1
Sitting height 4.2 29.6 54.5 -7.4 6.0 4.7 5.7 4.1 5.3 5.3 -4.7 5.3 5.7 -5.8 6.0 -5.8 -7.1 1.2 4.4
Chronic bronchitis/emphysema (father) 0.5 0.5 2.2 0.4 -0.4 -0.3 -0.5 -0.5 -0.1 -0.9 1.5 0.7 0.2 0.3 1.3 0.8 -0.3 0.7 1.1
High blood pressure (mother) 0.6 0.8 1.8 0.6 -1.4 -1.2 -1.1 -0.9 -1.2 -0.9 0.7 0.7 -0.2 0.6 1.3 0.3 -0.4 0.7 0.8
Body mass index (BMI) 2.1 9.0 22.8 4.4 -3.7 -2.9 -3.6 -3.1 -3.2 -2.5 3.5 -0.0 -3.2 4.8 -1.0 3.3 2.4 0.4 0.9
Impedance of leg (left) 0.9 4.6 23.4 -2.3 1.9 1.1 1.6 1.5 0.8 1.1 -2.1 -1.1 1.4 -4.8 -1.7 -2.8 -0.0 -1.7 -3.5
Leg predicted mass (left) 1.2 6.4 24.4 -2.3 1.5 1.3 1.4 0.5 1.6 2.4 -1.0 4.4 1.6 0.1 4.1 -1.1 -3.8 1.8 4.9
Trunk fat mass 0.4 1.5 6.8 0.4 -1.4 -1.4 -1.5 -1.9 -1.6 -0.2 0.5 2.6 -0.4 0.1 0.9 0.0 -0.8 -0.0 1.7
Waist circumference 1.2 4.4 11.0 2.9 -2.9 -2.1 -2.7 -2.4 -2.4 -1.8 2.1 0.4 -2.0 3.3 -0.3 2.1 1.1 0.5 1.0
Number of incorrect matches in round 1.0 1.6 8.2 -0.7 0.7 0.7 1.0 1.2 1.3 2.9 0.1 2.2 -0.1 0.6 0.2 0.6 -0.9 2.0 1.3
Past tobacco smoking 0.4 0.7 6.4 -0.1 0.2 -0.6 0.3 0.3 0.0 0.5 0.5 0.6 -0.1 -0.0 -1.3 1.0 -0.4 2.5 1.1
Alcohol usually taken with meals 2.3 3.8 7.9 -2.3 1.9 1.4 1.9 1.8 1.4 0.2 -2.8 -2.4 2.8 -2.5 -0.9 -2.3 -1.4 -0.6 -2.2
Nervous feelings 0.3 0.6 2.7 -0.3 0.6 0.4 1.0 1.2 1.2 1.6 -0.0 0.5 0.1 0.6 0.0 0.5 -0.5 1.2 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 5.9 -0.8 1.6 1.8 2.2 2.4 2.1 1.9 -1.4 0.5 1.4 0.3 1.2 -0.6 -0.8 0.6 0.2
Hearing difficulty/problems with background noise 0.7 1.2 6.1 1.5 -0.6 0.2 0.3 0.7 0.7 -0.6 0.9 -0.9 -1.1 2.5 -0.3 1.8 1.2 1.0 -0.2
Hair/balding pattern: Pattern 2 0.2 0.3 0.9 -0.2 0.5 0.6 0.7 0.5 0.9 0.6 -0.0 0.8 -0.3 -0.1 0.7 0.3 0.3 0.5 0.7
Had menopause 0.2 0.3 0.9 -0.2 0.1 0.2 0.5 0.6 0.5 0.3 -0.6 0.1 0.7 -0.4 -0.9 -0.8 -0.5 -0.5 -0.9
Had other major operations 0.4 0.5 1.4 -0.6 1.2 1.0 1.2 0.8 1.1 0.1 -0.4 0.6 0.6 0.3 -0.2 0.1 -0.4 0.6 0.6
Forced vital capacity (FVC) 1.2 4.5 8.6 -2.7 2.7 2.6 2.1 1.4 2.3 1.9 -1.6 2.0 1.2 -2.0 2.9 -2.1 -2.2 0.5 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.5 1.8 -1.3 -0.8 -1.1 -0.7 -0.9 -1.3 0.6 -1.6 -0.8 1.7 -1.9 1.6 1.2 1.0 -1.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 3.5 -0.8 1.6 1.8 1.7 1.5 1.9 0.6 -0.8 0.1 1.1 0.5 0.8 -0.7 -1.2 -0.2 1.0
Qualifications: None of the above 1.0 2.1 13.8 0.7 0.5 0.1 0.1 0.1 0.4 2.1 1.9 3.7 -1.2 0.0 0.2 1.6 0.4 2.1 1.7
Financial difficulties in last 2 years 1.6 2.1 5.7 2.0 -0.9 -0.5 -0.8 -0.2 -1.0 -0.5 1.7 -1.8 -1.5 1.6 -2.4 1.7 2.1 0.1 -1.4
Mouth/teeth dental problems 0.5 0.7 3.4 0.1 0.1 -0.4 -0.3 -0.5 -0.2 -0.1 1.0 0.5 0.5 -0.3 1.6 1.3 0.1 1.8 1.3
Heart attack 0.8 1.1 5.0 1.3 -0.5 0.2 0.2 0.9 0.5 -0.6 1.2 -0.4 -1.4 2.2 -0.3 1.5 1.6 0.8 0.1
Allergy 3.0 6.9 21.2 3.8 -2.1 -1.9 -2.3 -2.1 -2.4 -1.0 3.1 -1.5 -4.6 2.3 -3.0 2.4 3.6 -1.6 -1.5
Pain all over the body in last month 0.4 0.5 1.2 -0.7 0.4 0.7 0.7 0.8 0.9 1.1 -1.0 -0.2 -0.3 -0.2 -0.3 -0.8 0.2 -1.1 -0.2
Diabetes (self-reported) 1.1 1.7 5.2 1.4 -0.8 -0.3 -1.2 -0.9 -0.8 -0.0 1.8 2.2 -0.8 1.5 1.1 1.9 0.3 0.9 2.3
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 3.8 -1.9 1.8 1.6 1.9 1.9 1.9 0.9 -1.2 -0.3 1.8 -1.4 0.3 -1.3 -1.4 0.1 -0.3
Medication: Ramipril 1.7 2.2 8.1 1.9 -0.5 -0.1 -0.1 0.4 0.2 0.5 1.4 -0.8 -1.7 2.9 -2.0 2.7 1.6 1.8 -0.8
Medication: Simvastatin 0.8 1.2 10.2 0.0 0.7 0.6 0.4 -0.2 -0.1 0.7 0.1 3.2 0.2 -0.2 0.9 0.5 -0.8 1.3 2.1
Fluid intelligence score 1.4 3.0 8.0 -2.2 2.1 2.2 1.4 1.3 1.3 0.0 -2.7 -0.6 2.8 -2.3 0.8 -2.0 -1.3 -0.6 -0.8
Illnesses of siblings 1.2 1.7 4.5 -1.9 1.5 1.3 1.3 0.7 1.2 0.0 -2.0 -0.4 2.0 -2.1 0.8 -1.4 -0.8 -1.0 0.0
Neuroticism score 1.0 2.1 5.7 -1.5 1.1 0.9 1.3 0.8 1.6 0.8 -1.1 2.3 1.5 -0.7 1.9 -0.8 -1.9 0.3 2.4
Weight 0.5 2.3 11.7 -0.6 0.2 0.2 0.2 -0.4 0.3 1.1 0.2 3.3 0.3 0.8 2.4 -0.1 -2.0 1.1 3.4
Impedance of arm (right) 0.8 3.5 22.2 -3.0 0.6 -0.0 0.7 0.1 0.1 0.3 -2.9 0.2 2.2 -4.7 0.0 -2.5 -1.4 -0.7 -1.4
Arm fat percentage (right) 1.8 7.1 14.1 3.3 -3.8 -3.4 -3.7 -3.5 -3.6 -2.5 2.5 0.7 -2.5 2.9 -0.7 2.6 1.7 0.2 0.8
Trunk fat-free mass 2.1 12.2 31.4 -3.5 3.5 2.9 3.2 2.0 3.5 3.8 -1.5 4.9 2.6 -0.7 4.9 -1.6 -4.8 2.5 5.6
Hip circumference 0.3 1.2 3.5 0.3 -1.5 -1.5 -1.3 -1.4 -1.2 -1.0 0.2 1.3 -0.1 1.0 0.6 -0.2 -1.1 -0.1 1.9
Time employed in main current job 1.3 1.5 3.8 -1.7 1.2 1.1 0.8 0.5 0.9 0.3 -1.8 -0.7 1.7 -1.5 0.7 -2.0 -1.5 -0.8 -0.5
Alcohol intake versus 10 years previously 0.4 0.5 1.6 0.0 0.2 0.1 -0.0 -0.3 0.8 0.7 1.2 1.2 -0.4 0.7 0.1 1.2 0.2 0.8 1.3
Father’s age at death 1.4 1.9 7.3 -0.1 2.1 2.7 1.8 2.0 2.3 1.8 0.0 -0.1 0.3 0.8 0.3 0.5 0.1 1.3 -0.3
Worrier / anxious feelings 0.8 1.5 4.5 -1.1 1.3 1.5 1.7 1.6 2.1 0.1 -1.9 0.3 1.3 -0.0 1.3 -0.6 -0.7 0.1 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.9 0.9 -1.1 -0.5 -0.3 -0.2 0.0 -0.9 -0.1 -0.1 -1.2 1.4 0.1 0.4 0.7 -0.6 0.3
Falls in the last year 1.3 1.7 7.4 1.1 -0.5 0.0 -0.9 -1.2 -0.8 -1.7 0.5 -2.2 -0.8 0.1 -2.7 0.0 1.3 -1.6 -1.8
Hair/balding pattern: Pattern 3 0.6 0.8 2.0 -0.4 -0.2 -0.6 -1.0 -1.4 -1.2 -1.1 0.6 0.7 1.0 -1.3 1.2 -0.3 -0.7 -0.9 1.0
Number of live births 1.9 2.7 6.1 2.3 -1.9 -1.6 -1.6 -1.5 -2.0 -1.8 1.6 -0.3 -1.8 1.4 -1.1 2.1 2.5 0.1 -0.9
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 3.1 -0.5 1.6 1.8 1.2 1.2 1.3 1.0 -0.6 -0.7 -0.5 0.2 0.9 -0.7 -0.1 -0.1 0.1
Pulse rate 0.2 0.4 0.9 -0.1 -0.8 -0.7 -0.6 -0.6 -0.7 -0.7 -0.2 -0.4 0.7 -0.8 0.7 -0.4 0.1 -0.9 -0.2
Happiness 0.5 0.6 3.0 -0.3 -0.1 0.6 0.7 0.8 1.1 -0.3 -0.6 -1.7 0.3 1.1 -1.0 -0.1 -0.4 -0.0 -0.6
Noisy workplace 0.3 0.3 1.4 -0.3 -0.1 -0.3 0.3 0.7 0.3 0.9 1.0 -0.3 -0.3 -0.2 -1.2 -0.2 -0.1 0.5 -0.8
Qualifications: A levels/AS levels or equivalent 0.5 1.1 5.0 -0.0 -1.4 -1.1 -1.4 -1.3 -1.3 -2.2 -1.1 -0.8 0.8 0.0 1.3 0.3 0.3 0.1 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.9 0.6 -0.9 -0.8 -1.4 -1.3 -1.6 -1.7 0.9 -0.7 -0.7 -0.1 -0.6 0.1 1.0 -0.6 -0.7
Mouth/teeth dental problems: Dentures 1.6 2.7 8.8 2.2 -1.5 -1.4 -1.7 -1.5 -1.7 -0.3 1.5 0.4 -3.0 1.4 -2.4 1.0 1.9 -1.1 -1.1
Asthma 2.3 4.5 14.7 -3.2 1.7 1.6 1.5 1.0 1.4 1.0 -2.4 1.7 3.8 -2.5 2.4 -2.0 -2.8 0.5 1.4
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.6 0.8 -1.6 -1.5 -1.6 -1.1 -1.5 -1.2 1.1 -0.9 -0.8 0.0 -1.6 1.0 0.9 0.3 -0.7
Medication: Cholesterol lowering 0.4 0.6 3.1 0.0 1.1 0.9 1.0 0.8 0.5 0.6 -0.2 1.8 -0.4 0.4 0.3 0.0 -0.3 0.6 1.2
Depression (self-reported) 0.6 0.7 4.2 -0.8 0.2 0.0 0.1 -0.4 -0.1 1.2 -0.1 2.1 0.3 -1.2 0.8 -0.3 -0.8 0.4 1.1
Medication: Lansoprazole 0.9 1.0 4.1 0.7 1.7 2.0 1.1 1.6 0.7 0.8 0.7 0.1 -0.1 0.4 -0.8 0.3 1.0 0.1 -1.0
Prospective memory result 1.3 1.6 5.2 1.3 -0.1 -0.1 -0.0 0.4 0.3 1.2 1.8 1.3 -1.3 1.8 0.3 2.0 0.7 2.3 1.4
Lung cancer (father) 0.1 0.1 0.5 -0.4 0.4 0.1 0.3 -0.0 0.3 -0.1 0.2 0.1 0.3 0.1 0.1 0.4 -0.1 0.7 0.4
Illnesses of mother 2.2 2.7 9.7 -2.5 1.5 0.9 1.2 0.4 0.8 1.0 -1.8 1.1 1.6 -3.1 1.0 -2.5 -1.9 -1.4 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.5 -0.6 1.2 1.6 1.0 0.9 1.2 0.4 -0.7 -0.9 -0.4 0.2 1.3 -0.5 -0.3 -0.2 0.4
Pulse wave Arterial Stiffness index 0.6 0.7 2.4 1.1 -0.4 -0.3 -0.2 -0.5 -0.5 -0.1 1.3 1.4 -0.4 1.2 -0.1 1.6 0.5 0.9 1.0
Impedance of arm (left) 0.7 3.4 23.0 -2.9 0.8 0.2 0.9 0.4 0.3 0.8 -2.6 0.4 1.9 -4.8 -0.1 -2.5 -1.1 -0.8 -1.6
Arm fat mass (right) 0.8 3.3 6.1 2.1 -2.3 -2.0 -2.3 -2.4 -2.1 -1.1 1.9 1.7 -1.7 2.5 0.6 1.7 0.4 0.5 1.8
Trunk predicted mass 2.1 12.0 31.8 -3.5 3.5 2.9 3.1 2.0 3.4 3.7 -1.5 4.9 2.5 -0.7 4.9 -1.4 -4.8 2.6 5.6
Standing height 5.7 56.2 112.4 -10.6 8.1 6.5 7.8 5.2 7.4 7.6 -6.9 7.5 7.5 -8.5 7.6 -7.4 -9.7 1.7 5.9
Length of working week for main job 1.2 1.3 4.7 0.2 1.8 2.0 1.3 1.5 1.3 2.2 -0.4 -0.7 0.5 0.5 0.2 0.5 0.1 1.3 -0.9
Exposure to tobacco smoke at home 1.3 1.4 4.4 1.4 -0.9 -1.3 -0.9 -0.6 -0.7 -1.0 2.1 0.6 -1.6 0.9 -0.6 1.9 1.6 0.8 0.9
Breastfed as a baby 0.4 0.5 2.0 0.4 -0.1 -0.4 0.1 0.8 -0.4 -1.0 -0.4 -1.4 0.7 0.4 -0.3 0.2 0.9 -0.4 -1.4
Tense / ‘highly strung’ 2.1 3.5 9.3 -1.0 2.6 2.3 3.0 2.9 3.0 2.4 -0.5 1.2 1.2 0.3 0.8 0.8 -0.6 2.2 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.9 9.3 -2.0 2.3 2.6 2.7 2.5 3.0 2.1 -0.8 2.0 1.6 -1.0 1.6 -0.5 -1.6 1.9 1.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.5 0.2 -0.9 -1.2 -0.8 -0.7 -0.9 -0.5 0.5 0.9 0.2 0.6 0.2 0.4 -0.6 0.8 0.8
Birth weight of first child 1.8 3.2 8.7 -3.0 1.8 1.4 1.4 0.6 1.6 0.5 -2.4 0.9 1.5 -2.9 1.7 -2.5 -2.1 -0.9 0.9
Peak expiratory flow (PEF) 0.7 1.7 4.5 0.1 1.6 2.1 1.6 2.1 1.6 1.4 -0.4 -1.7 -1.2 1.5 -0.6 -0.3 0.6 -0.2 -1.2
Pulse wave reflection index 1.3 1.7 7.0 1.9 -0.5 -0.2 -0.4 -0.6 -0.2 -0.5 2.0 -0.1 -1.4 2.6 -0.3 2.2 1.0 1.1 1.3
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.6 0.3 0.7 1.5 1.3 1.6 1.3 -0.3 -0.7 -1.6 0.1 1.0 -1.0 0.7 0.6 0.3 -0.8
Loud music exposure frequency 1.8 2.0 9.8 1.0 -0.5 -0.2 -0.7 -0.1 -0.8 -0.9 0.8 -3.0 -0.6 0.1 -2.8 0.3 1.3 -0.2 -3.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 6.0 -0.4 0.2 0.2 -0.1 -0.1 -0.7 -1.5 -1.6 -2.4 0.2 -1.2 -1.0 -1.7 0.5 -2.1 -2.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.9 -0.3 0.3 0.9 0.4 0.4 0.6 -0.0 -0.7 -0.3 0.3 0.1 0.5 -0.8 -0.7 -0.3 -0.1
Blood clot in the leg (DVT) 0.6 0.8 1.6 0.6 -1.1 -1.0 -1.0 -0.6 -0.3 0.7 1.3 0.9 -1.0 1.2 -0.4 0.8 -0.2 1.1 0.9
Medication: Paracetamol 0.4 0.7 3.6 1.0 0.1 0.3 -0.6 -0.4 -0.3 0.8 1.9 0.3 -1.1 0.2 -1.5 0.8 0.9 -0.0 -0.8
Headache pain in last month 0.3 0.4 3.4 -0.5 0.0 -0.4 -0.3 -0.5 -0.5 -0.6 -0.5 0.1 0.9 -1.8 -0.1 -0.6 -0.2 -0.3 -0.8
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 3.1 -1.0 -0.8 -1.0 -0.7 -0.8 -0.8 -0.7 -1.2 -1.8 0.8 -1.5 -0.7 -1.4 -0.5 -1.3 -1.7
Glaucoma (self-reported) 0.9 1.0 2.8 -1.0 1.1 0.7 0.5 -0.3 0.0 -0.2 -1.0 1.5 0.9 -1.5 1.2 -0.7 -1.0 -1.1 1.7
Gout (self-reported) 0.4 0.5 1.5 0.7 0.8 1.2 0.7 0.8 1.0 0.2 0.5 -0.0 -0.3 0.7 -0.2 1.0 0.6 0.9 0.7
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.1 1.3 -0.7 -0.8 -1.4 -1.4 -1.8 -1.2 0.9 -1.2 -0.9 0.4 -1.7 0.5 1.3 -1.6 -1.2
Medication: Amlodipine 0.7 1.0 3.7 1.3 -0.5 -0.5 -0.4 -0.2 0.1 0.2 1.0 0.6 -1.2 1.9 1.4 1.1 0.7 1.2 1.4
Medication: Ventolin 100micrograms inhaler 1.2 1.6 4.1 -1.2 1.5 1.8 1.8 2.0 1.6 1.6 -0.3 1.1 0.6 -0.7 -0.7 0.2 -0.1 1.8 -0.0
Birth weight 2.9 6.3 12.2 -3.1 3.5 3.3 3.5 2.9 3.2 3.2 -2.0 0.9 1.8 -2.8 1.4 -2.5 -1.7 -0.3 -0.2
Chronic bronchitis/emphysema (mother) 1.9 2.2 8.9 1.9 -0.4 0.1 -0.1 0.4 0.4 1.2 2.2 -0.9 -2.1 3.0 -1.5 2.1 1.6 1.3 -0.6
High blood pressure (siblings) 1.7 2.5 5.6 1.8 -2.3 -1.9 -2.1 -1.8 -1.7 -0.2 2.4 0.7 -2.1 2.0 -0.1 1.4 0.2 0.5 0.8
Forced vital capacity (FVC), Best measure 1.4 5.3 10.6 -3.2 2.6 2.5 2.2 1.5 2.4 1.5 -2.4 1.5 1.9 -2.3 3.2 -2.4 -2.9 0.3 2.2
Body fat percentage 1.0 4.0 9.3 2.3 -2.9 -2.7 -2.9 -2.9 -3.0 -1.7 1.8 1.1 -1.9 1.3 -0.9 1.4 1.3 -0.4 0.2
Leg fat percentage (right) 1.7 6.1 11.5 3.4 -3.1 -2.9 -3.3 -2.9 -3.4 -2.4 2.5 -0.2 -2.4 2.5 -1.8 2.3 2.2 -0.4 -0.4
Arm fat-free mass (right) 1.4 7.3 18.8 -2.3 2.8 2.5 2.5 1.6 2.8 3.4 -0.8 4.2 1.4 -0.0 3.7 -1.2 -3.5 1.9 4.3
Exposure to tobacco smoke outside home 1.2 1.7 4.6 1.0 0.7 0.8 0.8 1.0 0.9 1.4 1.9 0.9 -1.9 1.3 -1.1 2.2 1.3 1.8 0.1
Comparative body size at age 10 1.8 5.0 14.4 3.8 -1.9 -1.5 -1.7 -0.8 -1.7 -1.8 2.1 -2.6 -2.9 3.3 -1.4 2.1 3.1 -0.4 -2.1
Number of full brothers 0.3 0.3 1.6 0.2 0.7 0.3 0.9 1.0 0.2 -0.2 -0.5 -0.2 0.4 0.5 -0.2 0.2 0.2 1.3 -0.6
Worry too long after embarrassment 0.4 0.7 3.2 1.2 -0.5 -0.3 -0.4 -0.3 -0.1 -0.6 0.7 0.6 -0.4 1.8 0.7 1.3 0.6 0.1 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.2 8.4 -1.7 2.4 2.7 2.5 2.4 2.9 2.6 -1.2 0.7 1.0 0.2 0.7 -0.4 -1.6 1.4 0.8
Wheeze or whistling in the chest in last year 0.3 0.5 2.1 -0.5 0.6 0.7 0.8 0.8 0.7 0.6 -0.8 1.4 0.6 0.5 0.7 0.1 -0.4 0.3 0.9
Number of children fathered 0.7 0.8 3.9 0.8 -0.3 -0.2 -0.1 0.2 -0.2 -0.0 0.4 -2.0 -0.6 0.7 -1.8 0.7 0.6 -0.4 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 3.5 0.9 -0.9 -0.6 -1.1 -0.9 -0.9 0.1 1.9 1.0 -1.0 1.1 0.6 1.3 0.3 0.6 1.3
Age at first live birth 0.3 0.5 1.2 -0.9 0.9 0.2 1.0 0.7 0.8 -0.3 -0.7 -0.5 1.1 -0.8 0.6 -0.0 -0.5 1.0 0.6
Pulse wave peak to peak time 1.2 1.4 4.1 -1.8 1.0 0.8 0.8 0.9 1.1 0.6 -1.7 -0.9 0.9 -1.8 0.5 -2.0 -1.1 -0.7 -0.8
Health satisfaction 0.5 0.7 1.8 0.5 1.2 1.4 1.2 1.2 1.3 -0.1 -0.0 -0.6 0.0 0.7 -0.4 0.8 0.5 0.6 -0.0
Shortness of breath walking on level ground 1.0 1.2 5.2 1.4 0.3 1.0 0.8 1.2 1.1 1.0 1.3 -0.3 -1.2 2.3 0.1 1.1 0.8 1.2 0.2
Qualifications: College or University degree 0.8 2.4 11.8 -1.0 -1.4 -1.2 -0.8 -0.7 -0.3 -3.0 -2.5 -3.4 1.6 -0.3 0.4 -1.1 -0.6 -1.2 -0.5
Eye problems/disorders: None of the above 0.6 0.7 2.7 1.1 -1.3 -1.0 -0.7 -0.4 -0.7 -0.3 0.8 -0.7 -1.0 1.6 -0.2 0.8 0.8 0.1 -0.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.8 0.2 -0.7 -0.2 -0.3 -0.3 -0.1 -0.5 -0.3 -0.1 0.0 0.3 -0.2 -0.2 -0.2 -1.3 0.1
Emphysema/chronic bronchitis 0.1 0.1 0.6 -0.2 -0.5 -0.7 -0.2 -0.2 -0.1 -0.1 -0.1 0.3 -0.4 -0.4 -0.5 -0.2 -0.1 -0.6 -0.3
Medication for pain relief, constipation, heartburn 2.2 3.8 9.5 -2.9 1.0 0.5 1.1 0.2 0.8 0.0 -3.0 0.6 2.8 -2.2 2.5 -3.0 -3.1 -1.1 1.0
Neck or shoulder pain in last month 0.7 0.9 4.1 0.5 -0.3 -0.5 -0.9 -1.1 -1.0 -0.7 1.5 2.0 -0.8 -0.2 0.2 1.0 0.2 1.0 1.1
Medication: Blood pressure 1.6 2.8 10.5 2.2 -0.1 0.7 0.3 0.9 1.0 1.0 2.3 0.6 -2.0 3.2 -0.3 2.8 1.5 2.1 1.1
Angina (self-reported) 0.7 0.9 2.4 1.0 -1.2 -1.1 -1.2 -0.9 -1.2 -0.6 0.7 -0.0 -0.9 0.6 -1.5 0.6 1.1 0.1 -1.0
Migraine (self-reported) 1.1 1.4 5.0 1.7 -0.2 0.2 -0.6 -0.4 -0.6 -1.4 0.7 -2.2 -0.6 -0.1 -1.5 0.2 1.8 -1.1 -2.1
Medication: Ibuprofen 0.6 0.7 2.7 0.5 -1.0 -0.9 -1.0 -0.5 -1.0 -0.6 0.7 -1.0 -0.4 -0.0 -1.6 0.6 0.8 0.2 -1.1
Medication: Allopurinol 0.3 0.5 1.6 0.5 0.5 0.9 0.3 0.3 0.6 0.5 0.2 0.9 -0.2 1.0 -0.5 0.7 -0.3 1.3 1.0
Medication: Omeprazole 1.0 1.2 4.3 0.4 0.7 0.8 1.6 2.1 1.4 1.5 0.4 -0.3 -1.2 1.4 -0.8 0.6 0.8 1.0 -1.1
Medication: Seretide 50 evohaler 0.7 0.8 3.3 -0.2 1.5 1.8 1.2 1.3 1.4 0.7 -0.1 0.1 0.5 0.7 0.1 0.1 -0.1 0.6 0.6
Mean time to correctly identify matches 0.5 0.9 2.7 -1.2 0.6 0.5 1.0 0.7 1.3 1.6 -0.3 1.0 0.7 -0.6 -0.1 0.0 -1.6 0.6 1.2
Heart disease (mother) 2.2 2.7 8.1 2.6 -1.6 -1.0 -1.2 -0.5 -0.9 -0.7 2.2 -0.9 -2.0 2.3 -0.7 2.8 2.3 1.0 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.2 3.8 8.9 2.0 -2.7 -2.3 -2.8 -2.3 -3.0 -1.0 0.8 -1.4 -2.1 0.9 -2.4 1.0 1.5 -0.9 -1.6
Whole body fat mass 0.4 1.8 5.3 0.9 -1.7 -1.6 -1.8 -2.1 -1.8 -0.6 1.1 2.3 -1.0 0.9 0.6 0.4 -0.3 -0.1 1.7
Leg fat mass (right) 0.7 2.6 4.5 2.0 -1.9 -1.8 -2.1 -2.1 -2.1 -0.9 1.8 1.5 -1.6 2.1 -0.1 1.4 0.6 0.3 1.3
Arm predicted mass (right) 1.3 6.8 17.9 -2.3 2.7 2.4 2.4 1.6 2.6 3.2 -0.9 4.0 1.3 -0.0 3.6 -1.2 -3.4 1.6 4.2
Pulse rate, automated reading 0.8 2.4 6.7 1.7 -2.6 -2.2 -2.6 -2.2 -2.4 -0.8 1.5 0.7 -1.0 1.0 0.1 1.2 0.8 -0.4 0.1
Alcohol intake frequency. 0.5 1.3 7.9 0.9 -0.6 -0.7 -0.4 -0.1 0.3 -0.2 2.8 1.2 -0.6 0.9 -0.1 2.0 0.8 1.1 1.2
Comparative height size at age 10 4.4 24.1 45.6 -6.0 5.8 4.6 5.8 4.3 5.8 6.8 -2.4 6.3 3.0 -4.2 4.6 -2.9 -5.6 2.9 4.5
Number of full sisters 0.3 0.3 0.9 -0.3 -0.7 -0.5 -0.9 -0.8 -0.4 0.8 0.5 0.2 0.3 0.4 0.6 0.5 -0.5 0.4 0.7
Suffer from ‘nerves’ 1.7 2.7 9.2 -1.8 1.8 1.4 2.0 2.2 2.1 3.0 -0.7 1.6 1.0 -0.9 0.7 -0.6 -1.6 1.7 1.1
Overall health rating 0.8 1.8 4.2 2.1 -1.3 -1.1 -1.2 -1.0 -1.1 -1.3 1.6 0.4 -1.5 1.8 -0.8 2.0 1.5 0.8 0.2
Chest pain or discomfort 0.9 1.3 3.7 0.7 -1.4 -1.2 -1.8 -1.8 -1.9 -1.6 1.0 0.6 -0.8 -0.7 -0.5 0.1 0.4 -0.1 0.5
Had major operations 0.6 0.7 2.7 -0.4 0.9 0.8 0.9 0.8 0.8 -0.5 0.3 0.5 0.9 0.4 1.6 1.0 -0.1 0.9 1.3
Age at last live birth 0.3 0.4 2.9 -0.7 0.5 -0.0 0.4 0.0 0.1 -0.3 -0.3 0.4 0.8 -1.2 0.0 0.3 -0.4 1.7 0.5
Family relationship satisfaction 1.5 1.9 7.7 1.6 -1.2 -0.5 -0.8 -0.3 -0.0 -2.0 0.6 -2.8 -0.6 1.8 -1.7 1.4 1.4 0.7 -1.4
Leg pain on walking 1.1 1.4 5.1 0.9 0.6 1.5 0.7 0.8 1.5 1.2 0.8 0.7 0.0 1.3 -0.2 2.2 0.9 2.3 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 2.5 -0.5 0.6 0.4 0.5 0.1 0.3 0.8 0.4 1.6 -0.7 0.4 0.1 0.0 -0.5 -0.0 1.1
Commuting to job workplace: Car/motor vehicle 1.7 1.9 5.1 0.5 1.7 2.3 1.7 2.2 2.2 1.6 1.0 -0.4 0.3 1.0 -0.4 0.6 0.8 1.8 -0.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.9 -0.6 0.1 -0.3 -0.0 -0.1 0.1 -0.2 -0.4 -0.9 0.9 -0.9 -0.1 -0.5 -0.3 -0.7 -0.9
Medication: Aspirin 1.2 1.6 4.4 2.1 -1.3 -1.3 -1.4 -0.8 -1.4 -1.5 1.5 -0.4 -1.0 1.5 -0.5 1.3 1.5 0.6 0.2
Supplements: Vitamin C 0.3 0.3 1.3 -0.3 0.9 1.1 0.8 0.8 0.8 0.4 -0.2 0.5 0.0 0.8 0.2 0.2 0.2 0.3 0.2
Knee pain experienced in last month 0.3 0.5 2.0 0.2 -0.0 0.3 -0.6 -0.9 -0.2 -0.4 1.4 1.4 -0.6 -0.4 0.3 0.4 -0.2 -0.2 1.4
Hypertension (Self-reported) 0.8 2.1 8.4 2.7 -1.2 -0.1 -0.8 -0.1 -0.3 -0.5 1.4 -0.0 -1.9 2.9 -1.0 2.1 1.9 0.7 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.5 -0.9 1.1 1.1 1.3 1.4 1.6 0.8 -0.9 1.1 0.2 -0.1 0.6 -0.3 -0.6 0.5 0.6
Illnesses of father: Heart disease 0.8 1.1 4.2 1.6 -0.6 -0.1 -0.6 -0.1 -0.1 -0.0 1.4 -0.2 -1.6 2.0 -0.3 1.5 1.1 1.3 0.1
Illnesses of siblings: Diabetes 0.3 0.4 1.9 1.0 -0.3 -0.1 -0.3 -0.1 -0.5 -0.3 0.5 -0.4 -0.8 1.4 -0.5 0.3 0.9 0.2 -0.3
Smoking status: Previous 0.5 0.7 2.7 -0.5 0.3 1.0 0.3 0.4 0.7 0.4 -0.9 -0.6 0.7 0.2 1.6 -1.1 -0.3 -1.5 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 7.8 -2.8 1.7 1.7 2.2 2.1 2.3 2.5 -2.3 0.5 1.5 -1.4 1.5 -2.0 -2.3 1.0 0.6
Whole body fat-free mass 1.7 10.0 29.8 -3.0 2.8 2.5 2.5 1.4 2.8 3.4 -1.3 4.9 2.1 -0.4 4.7 -1.4 -4.4 2.3 5.5
Leg fat-free mass (right) 1.3 6.8 23.9 -2.3 1.9 1.7 1.7 0.8 2.0 2.6 -0.9 4.3 1.5 0.1 4.2 -1.1 -3.8 1.8 4.9
Arm fat percentage (left) 1.9 7.4 13.8 3.6 -3.7 -3.2 -3.7 -3.4 -3.5 -2.3 2.8 0.6 -2.8 3.1 -0.9 2.7 2.0 0.1 0.6
Average weekly red wine intake 0.7 1.1 3.9 -0.7 0.0 0.2 0.4 0.4 0.1 -1.9 -2.0 -1.0 1.3 -0.4 1.3 -1.5 -0.8 -1.0 -0.4
Handedness (chirality/laterality): Left-handed 2.3 2.8 8.6 -1.0 2.8 2.9 2.6 2.5 2.8 2.0 -0.3 0.3 0.1 0.4 0.5 -0.5 -0.4 0.3 0.7
Mood swings 2.0 3.6 9.8 -2.3 1.6 1.3 1.1 0.5 1.4 0.4 -1.4 3.1 3.0 -2.5 2.3 -1.5 -2.1 0.2 2.4
Loneliness, isolation 0.4 0.5 1.6 0.6 -1.1 -0.9 -0.4 -0.5 -0.3 -0.5 0.5 0.6 -0.7 1.2 0.1 0.8 0.1 0.1 1.3
Long-standing illness, disability or infirmity 0.4 0.6 2.0 0.9 0.6 0.7 0.6 0.6 0.6 0.6 -0.0 0.5 -0.9 1.1 -0.3 1.4 0.7 0.8 0.5
Ever had bowel cancer screening 0.8 0.9 2.5 0.3 -1.4 -1.3 -1.2 -1.3 -0.8 -1.3 0.4 1.0 0.2 0.8 0.4 1.1 -0.3 0.4 1.6
Diabetes diagnosed by doctor 0.5 0.9 4.5 0.5 -0.5 -0.0 -0.7 -0.6 -0.4 0.3 0.8 2.1 -0.2 0.6 1.5 0.7 -0.2 0.2 2.1
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.7 6.8 2.2 0.4 0.8 -0.2 0.4 -0.1 -0.3 2.3 -1.9 -2.0 2.6 -2.5 1.5 2.4 0.4 -1.7
Friendships satisfaction 0.3 0.4 1.5 -0.4 -0.2 0.3 0.0 0.1 0.7 -0.8 -0.5 -1.2 0.0 0.6 -1.0 0.4 -0.3 0.9 -0.6
Qualifications: nursing, teaching 0.6 0.9 3.9 -1.0 -0.2 -0.1 -0.4 -0.8 -0.6 -0.8 -2.0 0.1 1.3 -0.9 1.4 -1.1 -1.0 -0.7 0.8
Commuting to job workplace: Walk 1.4 1.6 4.2 -1.5 0.3 -0.3 0.2 -0.4 -0.4 -0.3 -1.8 0.7 1.5 -0.7 2.0 -1.8 -1.5 -1.8 1.5
Eye problems/disorders: Cataract 2.3 2.7 6.8 -1.8 2.6 2.0 2.4 2.0 1.9 1.5 -1.7 -0.1 1.7 -1.5 -0.2 -1.6 -1.1 0.0 -1.0
Mouth/teeth dental problems: Mouth ulcers 3.2 5.0 11.7 -2.7 2.6 2.6 3.4 3.4 2.8 1.7 -3.0 -0.5 1.9 -0.8 -0.5 -2.7 -1.4 -1.1 -1.0
Medication for cholesterol 0.8 1.2 4.6 -1.9 0.3 -0.1 0.2 0.1 0.1 0.1 -1.1 -0.8 1.7 -2.1 0.5 -1.6 -1.1 -1.5 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.4 -0.4 0.8 1.5 1.3 1.5 1.6 0.9 -1.2 0.5 0.6 0.6 1.1 -0.4 0.0 0.6 0.2
Back pain experienced in last month 0.2 0.3 1.2 -0.8 -0.2 -0.0 -0.2 -0.4 -0.2 0.4 -0.4 0.4 0.5 -1.1 0.2 -1.0 -0.9 -0.7 0.0
Mineral and other dietary supplements 3.1 4.1 8.8 3.0 -2.1 -2.1 -2.3 -1.9 -2.4 -1.7 2.2 -2.4 -1.8 1.1 -2.0 1.4 2.3 -0.2 -2.1
Breast cancer (self-reported) 0.6 0.7 2.5 -0.9 0.0 0.0 -0.1 -0.4 -0.2 -0.1 -1.6 1.3 1.5 -1.2 0.6 -0.9 -1.0 0.5 0.3
Asthma (self-reported) 2.4 4.7 14.6 -3.3 1.8 1.7 1.7 1.2 1.5 1.1 -2.3 1.8 3.8 -2.4 2.6 -2.0 -2.9 0.4 1.5
Osteoporosis (self-reported) 0.2 0.3 1.3 -0.2 0.3 0.5 0.3 0.2 0.1 -0.2 -0.7 -0.5 1.0 -0.3 0.5 -0.6 -0.2 -1.1 -0.5
Osteoarthritis (self-reported) 1.0 1.3 3.2 -1.4 0.7 1.1 0.7 0.1 0.4 0.2 -1.7 1.8 1.2 -0.7 1.0 -1.4 -1.3 -1.3 1.3
Medication: Aspirin 1.1 1.5 4.9 2.2 -1.0 -1.0 -1.1 -0.5 -1.1 -1.4 1.4 -0.5 -0.9 1.7 -0.7 1.4 1.7 0.7 -0.3
Medication: Gliclazide 0.3 0.3 1.3 0.2 -0.4 -0.7 -0.2 -0.1 -0.0 0.2 0.9 1.0 -0.1 0.2 1.2 -0.2 -0.4 -0.3 1.1
Illnesses of father: None of the above (group 1) 0.9 1.1 3.2 -1.5 1.4 1.1 1.8 1.5 1.6 0.9 -1.1 -0.1 1.0 -0.9 0.1 -0.7 -0.2 -0.1 -0.3
Smoking status: Current 1.6 2.6 5.7 2.4 -1.7 -1.4 -1.5 -1.3 -1.7 -1.7 1.3 -0.7 -2.0 1.6 -1.9 1.7 2.3 -0.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 8.4 2.0 -2.4 -1.8 -2.8 -2.6 -2.3 -2.9 0.9 -1.3 -1.3 1.2 -1.0 1.9 1.5 -0.2 -0.1
Whole body water mass 1.7 9.5 29.7 -2.9 2.7 2.4 2.4 1.3 2.7 3.2 -1.2 4.8 2.0 -0.3 4.6 -1.2 -4.3 2.3 5.5
Leg predicted mass (right) 1.3 7.0 24.3 -2.4 1.8 1.7 1.7 0.7 2.0 2.6 -1.0 4.5 1.6 0.0 4.3 -1.2 -3.9 1.8 4.9
Arm fat mass (left) 0.8 3.4 6.3 2.1 -2.4 -2.1 -2.5 -2.5 -2.2 -1.2 1.8 1.8 -1.7 2.4 0.4 1.6 0.4 0.4 1.8
Number of self-reported non-cancer illnesses 1.0 1.7 5.6 -1.1 1.1 1.5 0.7 0.3 0.8 0.7 -1.1 2.4 1.6 -0.6 1.7 -0.8 -1.9 0.1 2.0
Average weekly champagne plus white wine intake 0.4 0.6 1.4 -0.7 -0.7 -1.1 -0.2 -0.1 -0.7 -0.7 -0.9 -1.1 0.5 -0.8 -0.8 -1.1 -0.5 -0.4 -1.2
Miserableness 1.5 2.5 5.6 -2.0 1.3 1.1 1.4 1.4 1.7 1.1 -1.8 1.4 1.9 -0.9 1.9 -2.3 -2.4 -0.0 1.0
Guilty feelings 1.9 2.9 10.3 1.1 -2.8 -2.5 -2.1 -2.2 -1.6 -3.2 0.9 0.5 -0.4 1.4 -0.1 1.5 -0.0 0.2 1.8
Wears glasses or contact lenses 1.6 1.9 4.8 2.2 -1.3 -0.5 -1.3 -0.9 -0.9 -1.2 1.6 -0.8 -1.5 1.6 -1.2 1.6 1.9 -0.3 -1.4
Ever taken oral contraceptive pill 0.6 0.6 1.5 0.6 -1.2 -0.7 -1.2 -0.9 -0.9 -0.6 0.2 0.2 -0.4 1.0 0.8 0.9 0.1 0.7 1.0
Hearing aid user 1.0 1.2 3.6 0.4 -1.1 -1.4 -1.1 -1.0 -1.3 -1.9 -0.0 -1.9 0.9 0.1 -0.3 -0.4 -0.1 -1.5 -0.9
Mother’s age at death 1.0 1.2 4.1 -1.4 -0.3 -0.6 -0.0 -0.3 0.2 -0.1 -1.7 0.7 1.5 -0.8 1.4 -1.7 -2.0 -0.1 1.0
Financial situation satisfaction 0.6 0.7 3.6 0.9 -0.3 0.2 -0.2 -0.1 -0.0 -1.2 0.7 -1.9 -0.8 1.1 -1.2 0.6 1.0 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 1.0 1.2 2.6 0.6 1.0 1.3 1.3 1.5 1.4 1.4 0.6 -1.6 -0.6 1.0 -1.2 0.2 0.3 0.5 -1.4
Commuting to job workplace: Public transport 0.4 0.5 1.9 -0.8 0.0 -0.4 -0.1 -0.6 -0.6 -1.3 -1.4 -0.6 0.4 -0.9 -0.1 -0.9 -0.3 -0.9 0.0
Eye problems/disorders: Glaucoma 0.5 0.6 3.3 -0.2 0.6 0.2 -0.3 -0.9 -0.5 -0.3 -0.2 1.8 0.1 -1.0 0.7 -0.1 -0.4 -0.8 1.6
Medication: Blood pressure 1.5 2.9 9.4 3.1 -1.2 -0.7 -1.0 -0.5 -0.9 -0.7 1.7 -0.7 -2.6 2.7 -0.9 2.4 2.5 0.9 -1.0
Pain type(s) experienced in last month: Hip pain 0.6 0.7 3.4 0.8 0.4 0.6 0.2 0.1 0.5 -0.1 0.9 0.5 -0.5 1.0 -1.2 1.9 0.5 1.6 0.4
Supplements: Fish oil (including cod liver oil) 2.7 3.5 7.4 -2.7 2.2 2.0 2.4 1.9 2.3 1.9 -2.4 1.8 1.5 -1.4 1.1 -1.4 -2.1 -0.1 1.1
High cholesterol (Self-reported) 1.1 1.9 7.8 -0.1 1.9 2.0 1.6 1.4 1.3 2.0 -0.0 2.8 0.1 -0.2 0.3 0.2 -0.6 2.0 1.0
Medication: Bendroflumethiazide 0.6 0.9 3.9 1.2 -0.7 0.0 -0.3 -0.2 0.3 0.0 1.0 0.6 -1.3 2.0 0.0 1.5 0.6 1.3 1.0
Medication: Paracetamol 0.4 0.6 2.3 0.2 0.9 0.9 0.4 0.4 0.4 1.5 1.3 0.8 -0.7 -0.1 -1.2 0.1 0.2 0.2 -0.5
Medication: Lisinopril 1.2 1.6 3.9 2.0 -0.9 -0.5 -0.8 -0.6 -0.8 -1.2 1.0 -1.3 -1.7 1.1 -1.5 1.8 1.9 -0.1 -1.3
Medication: Atorvastatin 0.4 0.5 1.5 -0.4 0.6 0.8 0.8 0.7 1.1 1.2 -0.3 0.4 -0.1 -0.2 -0.7 0.2 -0.3 1.2 0.1
Illnesses of father: High blood pressure 1.6 2.0 5.6 1.9 -0.7 -0.3 -1.1 -0.9 -1.9 -0.0 0.1 -1.5 -1.6 0.4 -2.0 0.1 1.8 -1.9 -2.4
Alcohol drinker status: Never 0.5 0.6 3.8 0.2 -0.8 -0.8 -0.5 -0.5 0.0 -0.7 0.5 0.7 0.0 0.7 0.3 1.1 -0.4 1.1 2.0
Ever smoked 0.4 0.7 5.8 0.1 0.1 0.5 -0.4 -0.6 -0.4 -0.9 -0.2 -0.3 0.1 -0.7 0.2 -0.9 0.5 -2.4 -1.3
Basal metabolic rate 1.4 7.6 25.8 -2.4 2.2 1.9 2.0 1.0 2.2 2.9 -0.9 4.6 1.6 -0.1 4.3 -1.1 -3.9 2.0 5.1
Leg fat percentage (left) 1.4 5.2 10.8 3.3 -2.7 -2.5 -2.9 -2.6 -3.0 -2.0 2.4 -0.1 -2.4 2.4 -1.8 2.1 2.2 -0.5 -0.5
Arm fat-free mass (left) 1.4 7.2 19.8 -2.4 2.8 2.3 2.4 1.4 2.5 2.9 -1.1 4.2 1.7 -0.4 3.8 -1.3 -3.7 1.7 4.5
Number of operations (self-reported) 0.8 1.2 4.9 -0.3 0.4 0.2 0.6 0.4 0.7 -1.0 0.6 1.8 1.1 0.7 1.6 0.9 -0.6 1.7 2.2
Average weekly beer plus cider intake 0.5 0.8 1.9 -1.1 0.9 1.1 1.0 0.8 1.4 0.9 -0.6 0.9 -0.2 -0.2 0.9 -0.5 -0.5 0.3 1.4
Irritability 1.1 1.9 4.5 -1.7 2.0 1.6 2.1 1.8 2.1 1.3 -0.9 1.1 0.9 -1.3 0.3 -0.8 -1.3 0.5 0.7
Risk taking 0.7 1.0 5.0 0.8 -0.9 -0.1 -0.5 -0.2 0.2 -0.4 -0.1 -2.2 -1.2 1.9 -1.6 0.6 0.8 -0.5 -0.7
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.9 -0.6 1.2 1.4 1.1 1.3 1.2 0.8 -0.1 0.7 0.5 0.7 -0.4 0.2 -0.5 0.9 0.4
Fractured/broken bones in last 5 years 2.8 3.7 10.3 -1.6 3.2 2.8 2.9 2.7 2.0 2.5 -1.7 0.8 1.2 -0.8 1.0 -2.0 -1.1 0.4 -0.2
Age started oral contraceptive pill 0.2 0.2 1.6 -0.4 0.2 0.0 0.4 0.2 0.5 0.1 -0.7 -0.0 0.4 -0.3 -1.3 -0.1 -0.1 -0.4 -0.5
Diastolic blood pressure, automated reading 1.4 4.4 10.5 2.3 -3.1 -3.2 -2.8 -2.6 -3.0 -0.8 2.0 0.6 -2.8 1.9 -1.2 1.3 1.1 -0.8 -0.1
Ever depressed for a whole week 2.6 3.2 7.3 -1.5 2.4 2.7 2.4 2.0 2.4 1.1 -2.1 -0.8 2.0 -0.9 0.4 -2.1 -1.4 -1.5 -0.5
Unable to work because of sickness or disability 0.5 0.7 1.7 0.3 0.8 0.9 1.0 1.1 1.1 1.3 0.6 0.3 -0.8 0.8 -0.6 0.6 0.7 0.9 -0.3
Commuting to job workplace: Cycle 0.9 1.1 3.7 -0.4 -1.1 -1.3 -1.4 -1.6 -1.4 -1.9 -1.2 -0.3 0.6 -1.3 0.0 0.0 -0.4 -0.3 0.3
Myopia 0.2 0.3 0.9 0.5 -0.4 -0.1 -0.3 -0.3 -0.2 -1.0 0.7 -0.6 -0.7 0.6 -0.5 0.7 0.9 -0.1 -0.3
Vascular/heart problems diagnosed by doctor 1.7 4.6 15.1 -3.8 1.8 0.7 1.4 0.6 0.9 0.9 -2.5 -0.1 2.8 -3.9 1.3 -3.4 -2.9 -1.1 0.4
Cholesterol lowering medication 0.7 1.0 4.6 0.9 0.1 0.4 -0.0 -0.2 -0.1 0.6 1.0 2.1 0.0 0.7 -0.2 1.6 0.2 2.1 1.0
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 5.4 0.4 0.8 0.9 1.7 2.3 1.7 1.9 0.6 -0.1 -1.6 1.6 -1.2 0.9 1.0 1.5 -1.2
Pain experienced in last month 0.6 1.0 3.9 -0.8 0.9 0.4 1.0 1.0 0.5 0.1 -2.0 -1.2 1.6 -0.2 0.7 -1.4 -0.5 -0.9 -0.8
Supplements: Calcium 2.1 2.4 3.4 -1.8 1.7 1.5 1.7 1.8 1.5 1.6 -1.4 1.6 1.8 -0.9 1.8 -0.9 -1.1 1.5 1.3
Basal cell carcinoma (self-reported) 0.6 0.8 2.2 0.6 1.1 1.5 0.9 0.7 0.7 -0.0 -0.4 -0.9 -0.7 0.2 -1.1 0.1 1.1 -0.8 -1.3
Heart attack/myocardial infarction (self-reported) 0.9 1.2 4.8 1.2 -0.2 0.4 0.4 1.1 0.7 -0.3 1.4 -0.1 -1.4 2.2 -0.3 1.7 1.6 1.0 0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.3 1.0 -1.3 -1.2 -1.1 -0.5 -0.5 0.8 1.4 0.7 -1.5 1.4 -0.7 0.9 0.3 1.0 0.4
Heart disease (siblings) 0.2 0.2 1.0 0.4 0.2 0.2 -0.2 0.1 -0.2 0.2 0.7 0.6 -0.6 -0.1 -1.0 0.0 0.4 0.7 -0.5
Alcohol drinker status: Previous 0.6 0.7 2.2 0.2 0.3 -0.0 0.5 0.7 0.7 1.2 1.5 0.9 -0.9 0.1 0.7 1.3 0.8 1.0 0.8
Pack years of smoking 1.8 2.6 7.5 2.1 -1.6 -1.5 -1.4 -0.9 -1.2 -0.4 2.2 -0.4 -2.7 2.0 -2.2 1.9 1.8 0.1 -0.6
Impedance of whole body 0.9 4.5 28.3 -2.9 1.3 0.6 1.3 0.9 0.5 1.0 -2.6 -0.3 1.9 -5.3 -1.0 -2.9 -0.7 -1.3 -2.8
Leg fat mass (left) 0.6 2.2 4.1 1.9 -1.6 -1.5 -1.8 -1.8 -1.8 -0.6 1.7 1.7 -1.6 2.0 -0.1 1.4 0.5 0.3 1.3
Arm predicted mass (left) 1.5 7.5 21.6 -2.5 2.7 2.3 2.4 1.3 2.5 2.8 -1.2 4.3 1.9 -0.4 4.0 -1.3 -3.8 1.8 4.7