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chr12:27,587,038-30,229,606

Best TWAS P=4.3e-26 · Best GWAS P=1.13e-22 conditioned to 0.00264

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC91	0.08	0.06	lasso	6	0.07	9.4e-09	-8.4	9.0	2.6e-19	0.60	0.97	0.03	FALSE
2	GTEx	Adipose Subcutaneous	RP11-967K21.1	0.08	0.02	lasso	8	0.01	2.1e-02	9.4	8.4	4.1e-17	0.83	0.06	0.90	FALSE
3	GTEx	Adipose Subcutaneous	RP11-996F15.2	0.46	0.38	lasso	10	0.38	4.1e-33	5.5	5.6	2.1e-08	-0.10	0.00	1.00	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-996F15.2	0.40	0.34	enet	12	0.33	7.9e-18	5.5	5.5	3.1e-08	-0.08	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	RP11-967K21.1	0.22	0.02	lasso	4	0.02	6.5e-02	9.5	8.3	9.8e-17	0.84	0.04	0.69	FALSE
6	GTEx	Adrenal Gland	RP11-996F15.2	0.62	0.55	lasso	7	0.55	3.0e-23	5.5	5.6	2.0e-08	-0.10	0.00	1.00	FALSE
7	GTEx	Artery Aorta	CCDC91	0.16	0.00	enet	37	0.02	4.1e-02	-8.5	-6.8	1.3e-11	-0.46	0.28	0.25	FALSE
8	GTEx	Artery Aorta	RP11-967K21.1	0.07	0.02	lasso	7	0.01	7.9e-02	9.1	10.5	1.3e-25	0.81	0.19	0.44	FALSE
9	GTEx	Artery Aorta	RP11-996F15.2	0.35	0.28	lasso	4	0.28	1.5e-15	5.5	5.5	2.9e-08	-0.09	0.00	1.00	FALSE
10	GTEx	Artery Coronary	RP11-967K21.1	0.18	0.12	lasso	7	0.07	1.8e-03	9.6	9.8	1.4e-22	0.87	0.03	0.95	FALSE
11	GTEx	Artery Coronary	RP11-996F15.2	0.54	0.44	enet	20	0.43	9.0e-16	5.6	5.3	1.2e-07	-0.09	0.00	1.00	FALSE
12	GTEx	Artery Tibial	RP11-967K21.1	0.09	0.10	lasso	11	0.07	2.4e-06	9.1	9.6	6.8e-22	0.83	0.26	0.74	FALSE
13	GTEx	Artery Tibial	RP11-996F15.2	0.44	0.40	enet	28	0.44	1.2e-37	5.6	5.8	8.8e-09	-0.11	0.00	1.00	FALSE
14	GTEx	Brain Cerebellum	RP11-996F15.2	0.25	0.15	lasso	4	0.10	7.6e-04	5.5	5.5	3.8e-08	-0.10	0.01	0.94	FALSE
15	GTEx	Breast Mammary Tissue	RP11-996F15.2	0.45	0.35	lasso	8	0.31	1.2e-16	5.6	5.6	1.8e-08	-0.11	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	RP11-996F15.2	0.52	0.28	lasso	9	0.23	4.1e-06	5.5	5.8	6.8e-09	-0.11	0.00	0.98	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RP11-996F15.2	0.42	0.38	lasso	1	0.35	3.5e-11	5.5	5.5	2.9e-08	-0.10	0.00	1.00	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	RP11-996F15.2	0.27	0.24	lasso	4	0.23	6.0e-08	5.5	5.5	3.3e-08	-0.08	0.00	1.00	FALSE
19	GTEx	Cells Transformed fibroblasts	ERGIC2	0.12	0.03	enet	23	0.05	1.4e-04	5.5	-5.7	1.2e-08	0.09	0.01	0.99	FALSE
20	GTEx	Cells Transformed fibroblasts	CCDC91	0.10	0.10	lasso	5	0.09	5.5e-07	-7.9	-7.9	2.9e-15	-0.45	0.98	0.01	FALSE
21	GTEx	Cells Transformed fibroblasts	RP11-967K21.1	0.07	0.07	lasso	2	0.07	3.7e-06	-8.9	9.0	2.6e-19	0.54	0.89	0.09	FALSE
22	GTEx	Cells Transformed fibroblasts	RP11-996F15.2	0.34	0.33	lasso	7	0.34	7.3e-26	5.5	5.4	7.6e-08	-0.08	0.00	1.00	FALSE
23	GTEx	Colon Sigmoid	RP11-996F15.2	0.42	0.27	lasso	7	0.29	7.7e-11	5.5	5.2	1.5e-07	-0.09	0.00	1.00	FALSE
24	GTEx	Colon Transverse	CCDC91	0.11	0.01	lasso	6	0.00	4.6e-01	-8.0	-9.9	3.6e-23	-0.75	0.19	0.49	FALSE
25	GTEx	Colon Transverse	RP11-967K21.1	0.12	0.07	lasso	8	0.05	1.6e-03	9.1	10.0	1.2e-23	0.87	0.10	0.84	FALSE
26	GTEx	Colon Transverse	RP11-996F15.2	0.31	0.32	lasso	1	0.31	3.5e-15	5.5	5.5	2.9e-08	-0.10	0.00	1.00	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	RP11-996F15.2	0.50	0.42	lasso	8	0.42	1.4e-16	5.5	5.4	5.4e-08	-0.09	0.00	1.00	FALSE
28	GTEx	Esophagus Mucosa	CCDC91	0.18	0.04	enet	36	0.03	3.1e-03	9.1	-5.8	4.9e-09	-0.45	0.21	0.51	FALSE
29	GTEx	Esophagus Mucosa	RP11-996F15.2	0.39	0.43	lasso	7	0.45	6.2e-33	5.5	5.3	8.6e-08	-0.10	0.00	1.00	FALSE
30	GTEx	Esophagus Muscularis	RP11-967K21.1	0.07	0.06	lasso	5	0.04	2.2e-03	9.2	9.9	3.0e-23	0.81	0.08	0.78	FALSE
31	GTEx	Esophagus Muscularis	RP11-996F15.2	0.56	0.45	enet	31	0.47	1.3e-31	5.5	5.2	1.7e-07	-0.08	0.00	1.00	FALSE
32	GTEx	Heart Atrial Appendage	CCDC91	0.10	0.06	lasso	8	0.04	4.4e-03	-7.9	-6.6	3.9e-11	-0.47	0.37	0.23	FALSE
33	GTEx	Heart Atrial Appendage	RP11-967K21.1	0.08	0.09	lasso	1	0.08	2.3e-04	-8.9	8.9	8.3e-19	0.54	0.42	0.15	FALSE
34	GTEx	Lung	CCDC91	0.14	0.00	enet	33	0.06	1.5e-05	-1.7	-5.2	1.5e-07	-0.28	0.22	0.28	FALSE
35	GTEx	Lung	RP11-996F15.2	0.50	0.46	lasso	5	0.46	1.9e-39	5.5	5.3	1.1e-07	-0.10	0.00	1.00	FALSE
36	GTEx	Muscle Skeletal	RP11-967K21.1	0.04	0.01	lasso	9	0.00	2.9e-01	-8.0	7.8	5.3e-15	0.47	0.30	0.07	FALSE
37	GTEx	Muscle Skeletal	RP11-996F15.2	0.24	0.26	lasso	11	0.25	9.3e-25	5.6	5.7	1.2e-08	-0.11	0.00	1.00	FALSE
38	GTEx	Nerve Tibial	RP11-996F15.2	0.52	0.53	lasso	5	0.56	3.3e-47	5.5	5.4	7.1e-08	-0.10	0.00	1.00	FALSE
39	GTEx	Ovary	RP11-996F15.2	0.50	0.46	enet	22	0.54	1.1e-15	5.3	5.2	2.5e-07	-0.08	0.01	0.99	FALSE
40	GTEx	Pancreas	RP11-996F15.2	0.56	0.46	enet	22	0.48	1.8e-22	5.5	5.6	2.7e-08	-0.08	0.00	1.00	FALSE
41	GTEx	Pituitary	RP11-967K21.1	0.20	0.04	lasso	7	0.04	4.4e-02	9.3	9.1	1.3e-19	0.64	0.11	0.20	FALSE
42	GTEx	Pituitary	RP11-996F15.2	0.54	0.42	lasso	8	0.32	7.7e-09	5.5	5.3	1.1e-07	-0.11	0.00	1.00	FALSE
43	GTEx	Prostate	RP11-996F15.2	0.49	0.36	enet	32	0.39	6.0e-11	5.5	5.7	1.2e-08	-0.09	0.00	1.00	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CCDC91	0.26	0.05	lasso	15	0.04	4.1e-03	-8.7	-8.8	2.0e-18	-0.47	0.80	0.14	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	RP11-996F15.2	0.44	0.28	enet	55	0.28	1.1e-15	5.5	5.4	5.6e-08	-0.06	0.00	1.00	FALSE
46	GTEx	Skin Sun Exposed Lower leg	CCDC91	0.09	0.01	enet	8	0.01	2.6e-02	-8.9	-9.3	1.5e-20	-0.59	0.26	0.56	FALSE
47	GTEx	Skin Sun Exposed Lower leg	RP11-996F15.2	0.50	0.48	enet	21	0.50	1.5e-47	5.6	5.7	9.9e-09	-0.08	0.00	1.00	FALSE
48	GTEx	Small Intestine Terminal Ileum	RP11-996F15.2	0.60	0.51	lasso	5	0.46	7.1e-12	5.6	5.6	1.9e-08	-0.10	0.00	1.00	FALSE
49	GTEx	Spleen	RP11-996F15.2	0.53	0.49	lasso	5	0.46	1.7e-13	5.6	5.6	2.0e-08	-0.11	0.00	1.00	FALSE
50	GTEx	Stomach	RP11-996F15.2	0.35	0.41	lasso	3	0.40	1.4e-20	5.5	5.5	3.4e-08	-0.09	0.00	1.00	FALSE
51	GTEx	Testis	RP11-996F15.2	0.28	0.35	lasso	2	0.37	2.7e-17	5.5	5.4	6.6e-08	-0.08	0.00	1.00	FALSE
52	GTEx	Thyroid	CCDC91	0.15	0.12	enet	42	0.12	2.9e-09	-8.5	-8.0	1.9e-15	-0.55	1.00	0.00	FALSE
53	GTEx	Thyroid	RP11-967K21.1	0.05	0.00	enet	7	0.00	2.8e-01	6.8	6.7	2.8e-11	0.61	0.04	0.72	FALSE
54	GTEx	Thyroid	RP11-996F15.2	0.54	0.54	lasso	8	0.55	9.1e-50	5.6	5.6	1.8e-08	-0.10	0.00	1.00	FALSE
55	GTEx	Whole Blood	RP11-996F15.2	0.20	0.18	enet	11	0.18	9.2e-17	5.5	5.5	3.3e-08	-0.12	0.00	1.00	FALSE
56	NTR	Blood	CCDC91	0.01	0.01	blup	648	0.00	9.0e-03	8.9	-9.9	2.9e-23	-0.73	0.13	0.70	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC91	0.04	0.04	lasso	3	0.03	1.8e-06	-8.4	-8.4	3.1e-17	-0.52	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERGIC2	0.03	0.00	blup	62	0.02	2.6e-04	-3.5	-5.2	2.0e-07	0.04	0.03	0.59	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC91	0.06	0.02	blup	174	0.04	2.9e-05	9.4	-10.6	4.3e-26	-0.83	0.05	0.94	TRUE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERGIC2	0.04	0.03	lasso	2	0.03	1.3e-04	5.5	-5.5	4.0e-08	0.09	0.00	0.99	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC91	0.09	0.01	blup	170	0.02	1.0e-03	-8.5	-8.5	2.0e-17	-0.56	0.20	0.64	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC91	0.09	0.11	lasso	2	0.12	2.3e-05	-8.6	-8.6	5.6e-18	-0.54	0.75	0.03	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC91	0.22	0.00	enet	16	0.04	2.5e-05	-1.1	-5.4	6.4e-08	-0.19	0.02	0.06	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC91	0.40	0.12	blup	175	0.14	4.9e-13	-8.3	-6.1	1.1e-09	-0.26	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	ERGIC2	0.19	0.10	blup	62	0.11	1.1e-10	5.3	-5.9	3.8e-09	0.11	0.01	0.99	TRUE