[Hub]/) : Traits : Sitting height :

chr12:14,220,891-15,807,367

Best TWAS P=6.35e-10 · Best GWAS P=3.32e-09 conditioned to 2.17e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C12orf60 0.28 0.25 lasso 4 0.24 2.0e-29 5.3 5.7 1.5e-08 -0.04 0.26 0.74 FALSE
2 GTEx Artery Tibial WBP11 0.09 0.06 lasso 2 0.06 3.8e-05 -4.8 5.2 1.7e-07 -0.03 0.34 0.64 FALSE
3 GTEx Brain Caudate basal ganglia C12orf60 0.39 0.34 lasso 3 0.32 5.4e-10 5.3 5.1 2.9e-07 -0.04 0.36 0.63 FALSE
4 GTEx Brain Cerebellum C12orf60 0.19 0.17 lasso 3 0.13 1.2e-04 5.3 5.5 4.1e-08 -0.06 0.13 0.32 FALSE
5 GTEx Brain Cortex C12orf60 0.44 0.28 lasso 3 0.29 1.2e-08 5.3 5.7 1.1e-08 -0.05 0.28 0.65 FALSE
6 GTEx Brain Nucleus accumbens basal ganglia RP11-174G6.5 0.23 0.13 lasso 4 0.11 8.9e-04 -5.5 5.5 3.4e-08 -0.07 0.14 0.39 FALSE
7 GTEx Brain Putamen basal ganglia C12orf60 0.33 0.32 lasso 3 0.29 1.5e-07 5.3 5.3 9.8e-08 -0.05 0.21 0.50 FALSE
8 GTEx Breast Mammary Tissue (Female) C12orf60 0.19 0.17 lasso 3 0.12 2.6e-04 5.3 5.3 1.0e-07 -0.04 0.13 0.26 FALSE
9 GTEx Cells Transformed fibroblasts C12orf60 0.10 0.10 lasso 2 0.09 1.8e-07 5.7 5.8 7.7e-09 -0.06 0.10 0.90 FALSE
10 GTEx Heart Left Ventricle C12orf60 0.24 0.23 lasso 5 0.26 7.1e-14 5.3 5.2 1.7e-07 -0.03 0.37 0.63 FALSE
11 GTEx Muscle Skeletal C12orf60 0.23 0.10 lasso 4 0.12 1.1e-11 5.3 5.7 1.5e-08 -0.04 0.19 0.80 FALSE
12 GTEx Nerve Tibial C12orf60 0.39 0.27 enet 11 0.30 9.6e-22 5.3 5.5 5.1e-08 -0.05 0.31 0.69 FALSE
13 GTEx Skin Not Sun Exposed Suprapubic C12orf60 0.15 0.16 lasso 2 0.13 1.6e-07 5.3 5.6 1.9e-08 -0.05 0.20 0.80 FALSE
14 GTEx Skin Sun Exposed Lower leg C12orf60 0.09 0.06 enet 11 0.05 4.0e-05 5.3 5.5 4.5e-08 -0.08 0.21 0.78 FALSE
15 GTEx Thyroid C12orf60 0.16 0.10 enet 9 0.12 8.1e-10 5.7 6.1 1.3e-09 -0.08 0.09 0.91 FALSE
16 METSIM Adipose C12orf60 0.14 0.10 lasso 4 0.08 1.2e-12 5.3 5.4 7.9e-08 -0.05 0.33 0.67 FALSE
17 METSIM Adipose MGP 0.04 0.04 bslmm 359 0.04 6.2e-07 -3.5 5.4 7.2e-08 -0.14 0.99 0.00 FALSE
18 NTR Blood ARHGDIB 0.01 0.00 blup 377 0.00 5.6e-02 -3.6 5.2 1.6e-07 -0.34 0.26 0.03 FALSE
19 ROSMAP Brain Pre-frontal Cortex WBP11 0.10 0.05 lasso 4 0.06 1.2e-08 -4.8 5.8 8.8e-09 -0.06 0.46 0.54 FALSE
20 ROSMAP Brain Pre-frontal Cortex C12orf60 0.26 0.29 lasso 5 0.29 1.9e-37 5.3 5.3 1.4e-07 -0.04 0.32 0.68 FALSE
21 YFS Blood H2AFJ 0.05 0.02 bslmm 360 0.03 2.9e-10 -4.8 -6.0 2.2e-09 0.09 0.27 0.73 FALSE
22 The Cancer Genome Atlas Bladder Urothelial Carcinoma C12orf60 0.17 0.03 blup 56 0.07 2.9e-06 5.7 5.5 3.9e-08 -0.01 0.00 0.99 FALSE
23 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C12orf60 0.12 0.07 enet 8 0.07 5.4e-05 5.3 6.0 2.4e-09 -0.03 0.02 0.95 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma C12orf60 0.14 0.14 lasso 4 0.13 2.2e-14 5.3 5.7 1.5e-08 -0.05 0.02 0.98 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma WBP11 0.03 0.03 blup 57 0.02 2.3e-03 -4.8 5.2 1.7e-07 -0.05 0.09 0.36 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma C12orf60 0.07 0.05 enet 7 0.05 1.5e-06 5.3 5.7 9.4e-09 -0.04 0.02 0.98 FALSE
27 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C12orf60 0.05 0.05 lasso 3 0.04 1.1e-05 5.3 5.5 4.1e-08 -0.04 0.01 0.98 FALSE
28 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C12orf60 0.10 0.01 blup 56 0.07 1.6e-05 5.7 5.3 9.2e-08 -0.10 0.01 0.88 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma C12orf60 0.05 0.03 lasso 1 0.01 1.2e-02 5.3 5.3 1.0e-07 -0.04 0.02 0.84 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma C12orf60 0.16 0.16 enet 10 0.18 1.3e-17 5.3 6.2 6.3e-10 -0.05 0.01 0.98 TRUE