[Hub]/) : Traits : Sitting height :

chr12:46,077,695-51,912,062

Best TWAS P=7.51e-21 · Best GWAS P=2.39e-24 conditioned to 5.63e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DIP2B 0.11 0.10 enet 16 0.13 2.6e-15 6.5 6.5 6.7e-11 0.03 0.28 0.72 FALSE
2 CommonMind Brain Pre-frontal Cortex SLC38A4 0.06 0.01 bslmm 376 0.02 2.9e-03 -6.7 5.8 7.5e-09 -0.60 0.05 0.70 FALSE
3 GTEx Adipose Subcutaneous ATF1 0.07 0.05 enet 14 0.04 3.1e-04 -5.3 -5.5 3.8e-08 -0.02 0.46 0.51 FALSE
4 GTEx Adipose Subcutaneous ZNF641 0.10 0.10 lasso 4 0.10 2.8e-08 5.6 5.5 3.0e-08 0.04 1.00 0.00 FALSE
5 GTEx Artery Aorta ATF1 0.26 0.29 lasso 2 0.28 1.5e-15 -5.5 -5.4 5.4e-08 -0.04 0.94 0.06 FALSE
6 GTEx Artery Aorta ZNF641 0.22 0.13 enet 30 0.18 4.9e-10 5.3 5.3 1.4e-07 0.03 0.99 0.01 FALSE
7 GTEx Artery Coronary ATF1 0.20 0.09 lasso 4 0.05 1.2e-02 -5.3 -5.3 1.4e-07 -0.04 0.21 0.22 FALSE
8 GTEx Artery Tibial ATF1 0.24 0.26 lasso 7 0.25 2.7e-19 -5.5 -5.5 4.9e-08 -0.04 0.94 0.06 FALSE
9 GTEx Artery Tibial ZNF641 0.19 0.16 lasso 5 0.16 1.6e-12 5.5 5.4 5.7e-08 0.03 1.00 0.00 FALSE
10 GTEx Artery Tibial RP4-605O3.4 0.04 0.01 lasso 4 0.00 3.2e-01 7.2 6.7 2.7e-11 0.03 0.02 0.93 FALSE
11 GTEx Brain Caudate basal ganglia LIMA1 0.18 0.12 lasso 5 0.07 3.9e-03 6.7 6.3 2.2e-10 0.04 0.02 0.84 FALSE
12 GTEx Brain Cerebellar Hemisphere PFKM 0.29 0.09 enet 14 0.06 1.5e-02 -6.6 7.3 3.3e-13 -0.01 0.28 0.15 TRUE
13 GTEx Brain Cerebellar Hemisphere RP4-605O3.4 0.18 0.12 enet 14 0.10 1.5e-03 7.2 6.8 1.4e-11 0.03 0.02 0.89 FALSE
14 GTEx Brain Cerebellum PFKM 0.20 0.07 lasso 10 0.07 4.2e-03 -7.8 7.1 1.4e-12 -0.02 0.19 0.33 FALSE
15 GTEx Brain Putamen basal ganglia CERS5 0.29 0.12 enet 36 0.21 1.2e-05 6.5 6.8 1.4e-11 0.06 0.11 0.79 FALSE
16 GTEx Brain Putamen basal ganglia RP1-228P16.1 0.21 0.24 lasso 6 0.24 2.1e-06 5.5 -5.2 1.9e-07 -0.05 0.51 0.08 FALSE
17 GTEx Cells Transformed fibroblasts SMARCD1 0.08 0.07 enet 5 0.07 9.3e-06 7.1 -6.8 9.0e-12 -0.03 0.03 0.96 FALSE
18 GTEx Cells Transformed fibroblasts ZNF641 0.10 0.05 lasso 4 0.05 7.5e-05 4.4 -5.9 3.7e-09 0.04 0.04 0.95 FALSE
19 GTEx Esophagus Gastroesophageal Junction ATF1 0.15 0.15 lasso 4 0.14 7.8e-06 -5.0 -5.3 1.4e-07 -0.02 0.64 0.09 FALSE
20 GTEx Esophagus Mucosa ZNF641 0.08 0.00 enet 23 0.01 1.0e-01 5.5 6.6 4.4e-11 0.01 0.02 0.96 FALSE
21 GTEx Esophagus Muscularis ATF1 0.15 0.17 lasso 2 0.16 7.5e-10 -5.5 -5.4 7.0e-08 -0.04 0.94 0.06 FALSE
22 GTEx Esophagus Muscularis CERS5 0.15 0.07 enet 18 0.09 2.7e-06 -4.8 5.6 2.1e-08 0.04 0.20 0.79 FALSE
23 GTEx Heart Atrial Appendage CERS5 0.14 0.03 lasso 6 0.02 4.2e-02 7.2 6.6 3.9e-11 0.03 0.04 0.92 FALSE
24 GTEx Heart Left Ventricle ZNF641 0.09 0.05 lasso 4 0.02 3.7e-02 -5.6 5.6 2.4e-08 -0.04 0.03 0.82 FALSE
25 GTEx Heart Left Ventricle RP11-96H19.1 0.29 0.04 enet 33 0.13 1.7e-07 3.0 5.3 9.2e-08 -0.68 0.03 0.96 FALSE
26 GTEx Lung ZNF641 0.08 0.10 lasso 2 0.08 8.0e-07 5.4 5.4 5.3e-08 0.04 0.99 0.00 FALSE
27 GTEx Muscle Skeletal DIP2B 0.03 0.04 lasso 6 0.04 1.1e-04 -5.5 -5.3 1.0e-07 -0.04 0.79 0.13 FALSE
28 GTEx Muscle Skeletal ATF1 0.09 0.06 lasso 5 0.07 5.0e-07 -5.5 -5.9 3.3e-09 -0.04 0.70 0.30 FALSE
29 GTEx Muscle Skeletal ZNF641 0.19 0.24 enet 7 0.20 4.0e-19 -8.7 -8.9 5.9e-19 0.01 0.00 1.00 TRUE
30 GTEx Nerve Tibial CERS5 0.31 0.28 enet 20 0.36 2.2e-26 7.2 7.1 1.4e-12 0.02 0.01 0.99 FALSE
31 GTEx Nerve Tibial ZNF641 0.14 0.11 lasso 4 0.08 2.3e-06 5.5 5.3 1.4e-07 0.03 1.00 0.00 FALSE
32 GTEx Nerve Tibial RP4-605O3.4 0.11 0.00 lasso 3 0.00 1.7e-01 7.2 5.8 5.0e-09 0.03 0.01 0.92 FALSE
33 GTEx Prostate CERS5 0.19 0.08 lasso 4 0.02 1.2e-01 7.3 7.3 2.8e-13 0.02 0.02 0.76 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic ZNF641 0.15 0.11 enet 30 0.10 3.1e-06 5.5 6.0 1.5e-09 0.03 0.98 0.01 FALSE
35 GTEx Skin Sun Exposed Lower leg SMARCD1 0.07 0.02 lasso 2 0.03 1.4e-03 -3.5 -5.5 4.8e-08 0.00 0.05 0.83 FALSE
36 GTEx Skin Sun Exposed Lower leg ZNF641 0.21 0.03 enet 17 0.08 6.5e-07 -6.7 7.1 1.5e-12 0.02 0.96 0.01 FALSE
37 GTEx Spleen ZNF641 0.42 0.21 lasso 11 0.28 5.4e-08 -6.2 6.5 6.4e-11 -0.01 0.07 0.91 FALSE
38 GTEx Testis SMARCD1 0.22 0.10 enet 22 0.10 2.6e-05 6.2 -6.7 2.4e-11 -0.02 0.01 0.98 FALSE
39 GTEx Testis CERS5 0.12 0.06 lasso 6 0.07 4.0e-04 7.2 7.2 6.8e-13 0.02 0.01 0.93 FALSE
40 GTEx Testis ZNF641 0.16 0.07 lasso 2 0.10 4.2e-05 -6.4 8.3 1.1e-16 0.00 0.13 0.71 FALSE
41 GTEx Thyroid LIMA1 0.08 0.06 enet 18 0.06 1.7e-05 6.5 6.2 4.8e-10 0.04 0.13 0.62 FALSE
42 GTEx Thyroid CERS5 0.09 0.04 lasso 9 0.04 3.7e-04 -4.3 5.7 1.0e-08 0.03 0.10 0.90 FALSE
43 GTEx Thyroid ZNF641 0.16 0.06 enet 26 0.13 2.0e-10 -5.6 8.4 3.1e-17 -0.02 0.03 0.97 FALSE
44 GTEx Thyroid RP11-579D7.2 0.14 0.02 enet 31 0.02 7.3e-03 -7.8 5.4 7.8e-08 0.02 0.14 0.06 FALSE
45 GTEx Vagina ZNF641 0.23 -0.01 enet 39 0.01 2.2e-01 -8.7 7.4 1.8e-13 0.01 0.01 0.89 FALSE
46 GTEx Whole Blood ZNF641 0.31 0.32 enet 19 0.32 1.7e-30 -6.2 5.5 4.0e-08 0.01 1.00 0.00 FALSE
47 GTEx Whole Blood RP4-605O3.4 0.04 0.04 lasso 4 0.01 1.5e-02 7.3 7.4 1.8e-13 0.02 0.01 0.97 TRUE
48 METSIM Adipose DKFZP779L1853 0.03 0.02 lasso 5 0.03 9.8e-06 -5.7 6.0 2.2e-09 -0.01 0.10 0.88 FALSE
49 METSIM Adipose SLC38A2 0.02 0.02 blup 341 0.01 5.8e-03 -9.8 8.7 3.2e-18 -0.87 0.08 0.86 FALSE
50 METSIM Adipose ZNF641 0.07 0.03 blup 487 0.06 7.0e-09 -8.7 5.7 9.8e-09 -0.04 0.01 0.99 FALSE
51 NTR Blood ATF1 0.06 0.07 enet 35 0.07 4.0e-21 6.0 5.3 8.9e-08 0.00 0.36 0.64 FALSE
52 YFS Blood ASB8 0.05 0.05 enet 21 0.05 3.6e-16 -5.8 5.4 8.0e-08 0.00 1.00 0.00 FALSE
53 YFS Blood ATF1 0.05 0.07 lasso 9 0.07 2.0e-21 6.0 6.4 1.2e-10 0.01 0.32 0.68 FALSE
54 YFS Blood LIMA1 0.04 0.06 enet 31 0.06 3.5e-19 -4.5 -5.9 3.5e-09 -0.04 1.00 0.00 FALSE
55 YFS Blood PFKM 0.03 0.00 blup 523 0.01 2.5e-05 -6.9 5.9 4.1e-09 -0.04 0.17 0.10 FALSE
56 YFS Blood ZNF641 0.43 0.53 bslmm 482 0.58 3.1e-241 -6.2 5.4 7.5e-08 0.01 1.00 0.00 FALSE
57 The Cancer Genome Atlas Breast Invasive Carcinoma C12orf62 0.01 0.00 blup 47 0.00 4.6e-02 -4.2 -6.2 4.9e-10 -0.03 0.02 0.45 FALSE
58 The Cancer Genome Atlas Breast Invasive Carcinoma SMARCD1 0.02 0.03 lasso 1 0.03 3.7e-06 6.7 -6.7 2.8e-11 -0.03 0.06 0.93 FALSE
59 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ZNF641 0.09 0.01 blup 50 0.03 8.7e-03 -8.8 5.3 1.2e-07 -0.02 0.00 0.94 FALSE
60 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C12orf62 0.02 0.01 blup 47 0.01 1.7e-02 -4.3 -6.0 1.7e-09 -0.03 0.03 0.36 FALSE
61 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZNF641 0.04 0.03 lasso 1 0.03 5.9e-04 -7.8 7.8 4.2e-15 0.00 0.03 0.56 FALSE
62 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ASB8 0.04 0.03 blup 69 0.03 4.1e-04 5.4 6.8 7.7e-12 -0.01 0.21 0.25 FALSE
63 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIMA1 0.08 0.10 blup 59 0.10 1.8e-11 6.5 -6.6 5.4e-11 -0.02 0.23 0.77 FALSE
64 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZNF641 0.09 0.01 blup 50 0.06 7.1e-07 2.4 5.9 3.3e-09 0.01 0.07 0.53 FALSE
65 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C12orf62 0.08 0.01 blup 47 0.06 3.2e-04 -4.2 -5.2 1.9e-07 -0.04 0.20 0.66 FALSE
66 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC38A2 0.10 0.06 blup 30 0.05 8.3e-04 -10.2 9.4 7.5e-21 -0.91 0.01 0.93 TRUE
67 The Cancer Genome Atlas Brain Lower Grade Glioma ASB8 0.08 0.01 blup 69 0.04 3.9e-05 4.0 7.4 1.1e-13 -0.03 0.13 0.76 FALSE
68 The Cancer Genome Atlas Brain Lower Grade Glioma ATF1 0.03 0.04 lasso 1 0.04 6.3e-05 6.0 -6.0 2.1e-09 0.00 0.01 0.99 FALSE
69 The Cancer Genome Atlas Lung Adenocarcinoma ASB8 0.03 0.00 blup 69 0.01 1.2e-02 -5.6 5.3 1.1e-07 -0.02 0.05 0.08 FALSE
70 The Cancer Genome Atlas Lung Adenocarcinoma ZNF641 0.03 0.03 lasso 7 0.03 3.1e-04 -7.4 7.6 2.4e-14 -0.01 0.03 0.78 FALSE
71 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ZNF641 0.03 0.00 blup 50 0.01 2.6e-02 -8.7 8.6 1.0e-17 -0.02 0.00 0.84 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma ZNF641 0.06 0.03 lasso 3 0.03 3.3e-04 -8.7 7.4 1.3e-13 -0.01 0.00 0.98 FALSE
73 The Cancer Genome Atlas Soft Tissue Sarcoma SLC38A2 0.06 0.01 blup 30 0.03 5.1e-03 -10.1 9.0 2.2e-19 -0.92 0.01 0.78 FALSE
74 The Cancer Genome Atlas Thyroid Carcinoma C12orf62 0.06 0.02 blup 47 0.05 1.8e-05 -3.0 -5.4 5.6e-08 -0.04 0.04 0.94 FALSE
75 The Cancer Genome Atlas Thyroid Carcinoma ZNF641 0.11 0.12 enet 10 0.12 5.2e-12 5.0 6.0 2.6e-09 0.02 0.97 0.03 FALSE