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chr12:46,077,695-51,912,062

Best TWAS P=7.51e-21 · Best GWAS P=2.39e-24 conditioned to 5.63e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DIP2B	0.11	0.10	enet	16	0.13	2.6e-15	6.5	6.5	6.7e-11	0.03	0.28	0.72	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC38A4	0.06	0.01	bslmm	376	0.02	2.9e-03	-6.7	5.8	7.5e-09	-0.60	0.05	0.70	FALSE
3	GTEx	Adipose Subcutaneous	ATF1	0.07	0.05	enet	14	0.04	3.1e-04	-5.3	-5.5	3.8e-08	-0.02	0.46	0.51	FALSE
4	GTEx	Adipose Subcutaneous	ZNF641	0.10	0.10	lasso	4	0.10	2.8e-08	5.6	5.5	3.0e-08	0.04	1.00	0.00	FALSE
5	GTEx	Artery Aorta	ATF1	0.26	0.29	lasso	2	0.28	1.5e-15	-5.5	-5.4	5.4e-08	-0.04	0.94	0.06	FALSE
6	GTEx	Artery Aorta	ZNF641	0.22	0.13	enet	30	0.18	4.9e-10	5.3	5.3	1.4e-07	0.03	0.99	0.01	FALSE
7	GTEx	Artery Coronary	ATF1	0.20	0.09	lasso	4	0.05	1.2e-02	-5.3	-5.3	1.4e-07	-0.04	0.21	0.22	FALSE
8	GTEx	Artery Tibial	ATF1	0.24	0.26	lasso	7	0.25	2.7e-19	-5.5	-5.5	4.9e-08	-0.04	0.94	0.06	FALSE
9	GTEx	Artery Tibial	ZNF641	0.19	0.16	lasso	5	0.16	1.6e-12	5.5	5.4	5.7e-08	0.03	1.00	0.00	FALSE
10	GTEx	Artery Tibial	RP4-605O3.4	0.04	0.01	lasso	4	0.00	3.2e-01	7.2	6.7	2.7e-11	0.03	0.02	0.93	FALSE
11	GTEx	Brain Caudate basal ganglia	LIMA1	0.18	0.12	lasso	5	0.07	3.9e-03	6.7	6.3	2.2e-10	0.04	0.02	0.84	FALSE
12	GTEx	Brain Cerebellar Hemisphere	PFKM	0.29	0.09	enet	14	0.06	1.5e-02	-6.6	7.3	3.3e-13	-0.01	0.28	0.15	TRUE
13	GTEx	Brain Cerebellar Hemisphere	RP4-605O3.4	0.18	0.12	enet	14	0.10	1.5e-03	7.2	6.8	1.4e-11	0.03	0.02	0.89	FALSE
14	GTEx	Brain Cerebellum	PFKM	0.20	0.07	lasso	10	0.07	4.2e-03	-7.8	7.1	1.4e-12	-0.02	0.19	0.33	FALSE
15	GTEx	Brain Putamen basal ganglia	CERS5	0.29	0.12	enet	36	0.21	1.2e-05	6.5	6.8	1.4e-11	0.06	0.11	0.79	FALSE
16	GTEx	Brain Putamen basal ganglia	RP1-228P16.1	0.21	0.24	lasso	6	0.24	2.1e-06	5.5	-5.2	1.9e-07	-0.05	0.51	0.08	FALSE
17	GTEx	Cells Transformed fibroblasts	SMARCD1	0.08	0.07	enet	5	0.07	9.3e-06	7.1	-6.8	9.0e-12	-0.03	0.03	0.96	FALSE
18	GTEx	Cells Transformed fibroblasts	ZNF641	0.10	0.05	lasso	4	0.05	7.5e-05	4.4	-5.9	3.7e-09	0.04	0.04	0.95	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	ATF1	0.15	0.15	lasso	4	0.14	7.8e-06	-5.0	-5.3	1.4e-07	-0.02	0.64	0.09	FALSE
20	GTEx	Esophagus Mucosa	ZNF641	0.08	0.00	enet	23	0.01	1.0e-01	5.5	6.6	4.4e-11	0.01	0.02	0.96	FALSE
21	GTEx	Esophagus Muscularis	ATF1	0.15	0.17	lasso	2	0.16	7.5e-10	-5.5	-5.4	7.0e-08	-0.04	0.94	0.06	FALSE
22	GTEx	Esophagus Muscularis	CERS5	0.15	0.07	enet	18	0.09	2.7e-06	-4.8	5.6	2.1e-08	0.04	0.20	0.79	FALSE
23	GTEx	Heart Atrial Appendage	CERS5	0.14	0.03	lasso	6	0.02	4.2e-02	7.2	6.6	3.9e-11	0.03	0.04	0.92	FALSE
24	GTEx	Heart Left Ventricle	ZNF641	0.09	0.05	lasso	4	0.02	3.7e-02	-5.6	5.6	2.4e-08	-0.04	0.03	0.82	FALSE
25	GTEx	Heart Left Ventricle	RP11-96H19.1	0.29	0.04	enet	33	0.13	1.7e-07	3.0	5.3	9.2e-08	-0.68	0.03	0.96	FALSE
26	GTEx	Lung	ZNF641	0.08	0.10	lasso	2	0.08	8.0e-07	5.4	5.4	5.3e-08	0.04	0.99	0.00	FALSE
27	GTEx	Muscle Skeletal	DIP2B	0.03	0.04	lasso	6	0.04	1.1e-04	-5.5	-5.3	1.0e-07	-0.04	0.79	0.13	FALSE
28	GTEx	Muscle Skeletal	ATF1	0.09	0.06	lasso	5	0.07	5.0e-07	-5.5	-5.9	3.3e-09	-0.04	0.70	0.30	FALSE
29	GTEx	Muscle Skeletal	ZNF641	0.19	0.24	enet	7	0.20	4.0e-19	-8.7	-8.9	5.9e-19	0.01	0.00	1.00	TRUE
30	GTEx	Nerve Tibial	CERS5	0.31	0.28	enet	20	0.36	2.2e-26	7.2	7.1	1.4e-12	0.02	0.01	0.99	FALSE
31	GTEx	Nerve Tibial	ZNF641	0.14	0.11	lasso	4	0.08	2.3e-06	5.5	5.3	1.4e-07	0.03	1.00	0.00	FALSE
32	GTEx	Nerve Tibial	RP4-605O3.4	0.11	0.00	lasso	3	0.00	1.7e-01	7.2	5.8	5.0e-09	0.03	0.01	0.92	FALSE
33	GTEx	Prostate	CERS5	0.19	0.08	lasso	4	0.02	1.2e-01	7.3	7.3	2.8e-13	0.02	0.02	0.76	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	5.5	6.0	1.5e-09	0.03	0.98	0.01	FALSE
35	GTEx	Skin Sun Exposed Lower leg	SMARCD1	0.07	0.02	lasso	2	0.03	1.4e-03	-3.5	-5.5	4.8e-08	0.00	0.05	0.83	FALSE
36	GTEx	Skin Sun Exposed Lower leg	ZNF641	0.21	0.03	enet	17	0.08	6.5e-07	-6.7	7.1	1.5e-12	0.02	0.96	0.01	FALSE
37	GTEx	Spleen	ZNF641	0.42	0.21	lasso	11	0.28	5.4e-08	-6.2	6.5	6.4e-11	-0.01	0.07	0.91	FALSE
38	GTEx	Testis	SMARCD1	0.22	0.10	enet	22	0.10	2.6e-05	6.2	-6.7	2.4e-11	-0.02	0.01	0.98	FALSE
39	GTEx	Testis	CERS5	0.12	0.06	lasso	6	0.07	4.0e-04	7.2	7.2	6.8e-13	0.02	0.01	0.93	FALSE
40	GTEx	Testis	ZNF641	0.16	0.07	lasso	2	0.10	4.2e-05	-6.4	8.3	1.1e-16	0.00	0.13	0.71	FALSE
41	GTEx	Thyroid	LIMA1	0.08	0.06	enet	18	0.06	1.7e-05	6.5	6.2	4.8e-10	0.04	0.13	0.62	FALSE
42	GTEx	Thyroid	CERS5	0.09	0.04	lasso	9	0.04	3.7e-04	-4.3	5.7	1.0e-08	0.03	0.10	0.90	FALSE
43	GTEx	Thyroid	ZNF641	0.16	0.06	enet	26	0.13	2.0e-10	-5.6	8.4	3.1e-17	-0.02	0.03	0.97	FALSE
44	GTEx	Thyroid	RP11-579D7.2	0.14	0.02	enet	31	0.02	7.3e-03	-7.8	5.4	7.8e-08	0.02	0.14	0.06	FALSE
45	GTEx	Vagina	ZNF641	0.23	-0.01	enet	39	0.01	2.2e-01	-8.7	7.4	1.8e-13	0.01	0.01	0.89	FALSE
46	GTEx	Whole Blood	ZNF641	0.31	0.32	enet	19	0.32	1.7e-30	-6.2	5.5	4.0e-08	0.01	1.00	0.00	FALSE
47	GTEx	Whole Blood	RP4-605O3.4	0.04	0.04	lasso	4	0.01	1.5e-02	7.3	7.4	1.8e-13	0.02	0.01	0.97	TRUE
48	METSIM	Adipose	DKFZP779L1853	0.03	0.02	lasso	5	0.03	9.8e-06	-5.7	6.0	2.2e-09	-0.01	0.10	0.88	FALSE
49	METSIM	Adipose	SLC38A2	0.02	0.02	blup	341	0.01	5.8e-03	-9.8	8.7	3.2e-18	-0.87	0.08	0.86	FALSE
50	METSIM	Adipose	ZNF641	0.07	0.03	blup	487	0.06	7.0e-09	-8.7	5.7	9.8e-09	-0.04	0.01	0.99	FALSE
51	NTR	Blood	ATF1	0.06	0.07	enet	35	0.07	4.0e-21	6.0	5.3	8.9e-08	0.00	0.36	0.64	FALSE
52	YFS	Blood	ASB8	0.05	0.05	enet	21	0.05	3.6e-16	-5.8	5.4	8.0e-08	0.00	1.00	0.00	FALSE
53	YFS	Blood	ATF1	0.05	0.07	lasso	9	0.07	2.0e-21	6.0	6.4	1.2e-10	0.01	0.32	0.68	FALSE
54	YFS	Blood	LIMA1	0.04	0.06	enet	31	0.06	3.5e-19	-4.5	-5.9	3.5e-09	-0.04	1.00	0.00	FALSE
55	YFS	Blood	PFKM	0.03	0.00	blup	523	0.01	2.5e-05	-6.9	5.9	4.1e-09	-0.04	0.17	0.10	FALSE
56	YFS	Blood	ZNF641	0.43	0.53	bslmm	482	0.58	3.1e-241	-6.2	5.4	7.5e-08	0.01	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf62	0.01	0.00	blup	47	0.00	4.6e-02	-4.2	-6.2	4.9e-10	-0.03	0.02	0.45	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMARCD1	0.02	0.03	lasso	1	0.03	3.7e-06	6.7	-6.7	2.8e-11	-0.03	0.06	0.93	FALSE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZNF641	0.09	0.01	blup	50	0.03	8.7e-03	-8.8	5.3	1.2e-07	-0.02	0.00	0.94	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf62	0.02	0.01	blup	47	0.01	1.7e-02	-4.3	-6.0	1.7e-09	-0.03	0.03	0.36	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF641	0.04	0.03	lasso	1	0.03	5.9e-04	-7.8	7.8	4.2e-15	0.00	0.03	0.56	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB8	0.04	0.03	blup	69	0.03	4.1e-04	5.4	6.8	7.7e-12	-0.01	0.21	0.25	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIMA1	0.08	0.10	blup	59	0.10	1.8e-11	6.5	-6.6	5.4e-11	-0.02	0.23	0.77	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF641	0.09	0.01	blup	50	0.06	7.1e-07	2.4	5.9	3.3e-09	0.01	0.07	0.53	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf62	0.08	0.01	blup	47	0.06	3.2e-04	-4.2	-5.2	1.9e-07	-0.04	0.20	0.66	FALSE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC38A2	0.10	0.06	blup	30	0.05	8.3e-04	-10.2	9.4	7.5e-21	-0.91	0.01	0.93	TRUE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB8	0.08	0.01	blup	69	0.04	3.9e-05	4.0	7.4	1.1e-13	-0.03	0.13	0.76	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATF1	0.03	0.04	lasso	1	0.04	6.3e-05	6.0	-6.0	2.1e-09	0.00	0.01	0.99	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	ASB8	0.03	0.00	blup	69	0.01	1.2e-02	-5.6	5.3	1.1e-07	-0.02	0.05	0.08	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF641	0.03	0.03	lasso	7	0.03	3.1e-04	-7.4	7.6	2.4e-14	-0.01	0.03	0.78	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF641	0.03	0.00	blup	50	0.01	2.6e-02	-8.7	8.6	1.0e-17	-0.02	0.00	0.84	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF641	0.06	0.03	lasso	3	0.03	3.3e-04	-8.7	7.4	1.3e-13	-0.01	0.00	0.98	FALSE
73	The Cancer Genome Atlas	Soft Tissue Sarcoma	SLC38A2	0.06	0.01	blup	30	0.03	5.1e-03	-10.1	9.0	2.2e-19	-0.92	0.01	0.78	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf62	0.06	0.02	blup	47	0.05	1.8e-05	-3.0	-5.4	5.6e-08	-0.04	0.04	0.94	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF641	0.11	0.12	enet	10	0.12	5.2e-12	5.0	6.0	2.6e-09	0.02	0.97	0.03	FALSE