Best TWAS P=5.24e-12 · Best GWAS P=2.33e-12 conditioned to 0.283
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PRR13 | 0.13 | 0.10 | lasso | 7 | 0.09 | 9.2e-08 | 3.94 | -5.2 | 2.2e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | PRR13 | 0.18 | 0.02 | lasso | 10 | 0.04 | 1.3e-02 | -0.48 | 6.4 | 1.7e-10 | 0.50 | 0.08 | 0.22 | FALSE |
| 3 | GTEx | Artery Coronary | SP1 | 0.17 | 0.12 | lasso | 4 | 0.12 | 8.6e-05 | 5.01 | 6.4 | 1.3e-10 | 0.21 | 0.35 | 0.15 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PRR13 | 0.22 | 0.08 | lasso | 5 | 0.17 | 6.5e-14 | 3.83 | -5.5 | 4.5e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 5 | METSIM | Adipose | SOAT2 | 0.03 | 0.06 | lasso | 1 | 0.05 | 1.5e-08 | 6.20 | -6.2 | 5.6e-10 | -0.76 | 0.41 | 0.59 | FALSE |
| 6 | METSIM | Adipose | SP7 | 0.03 | 0.02 | lasso | 2 | 0.01 | 6.1e-03 | 6.20 | -6.9 | 5.2e-12 | -0.85 | 0.01 | 0.95 | TRUE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRR13 | 0.13 | 0.04 | blup | 28 | 0.07 | 3.3e-06 | 4.90 | -5.4 | 7.1e-08 | 0.01 | 0.02 | 0.76 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PRR13 | 0.03 | 0.03 | blup | 28 | 0.04 | 4.6e-05 | 4.49 | -5.3 | 1.4e-07 | -0.05 | 0.04 | 0.89 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRR13 | 0.05 | 0.03 | blup | 28 | 0.04 | 4.1e-03 | 3.94 | -5.7 | 1.1e-08 | -0.08 | 0.02 | 0.32 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRR13 | 0.07 | 0.04 | blup | 28 | 0.05 | 4.7e-06 | 3.94 | -5.9 | 4.7e-09 | -0.10 | 0.08 | 0.79 | TRUE |
| 11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PCBP2 | 0.25 | 0.04 | blup | 36 | 0.10 | 2.3e-03 | -3.98 | -5.1 | 2.8e-07 | -0.09 | 0.01 | 0.23 | FALSE |