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chr16:14,106,741-16,173,221

Best TWAS P=2.15e-13 · Best GWAS P=1.46e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	NTAN1	0.05	0.03	lasso	2	0.04	6.7e-04	-7.0	7.3	2.1e-13	-0.97	0.01	0.97	TRUE
2	GTEx	Artery Coronary	NPIPA5	0.30	0.03	enet	13	0.07	3.1e-03	-4.8	5.2	2.0e-07	-0.65	0.02	0.79	FALSE
3	GTEx	Artery Tibial	RRN3	0.11	0.06	lasso	2	0.07	2.0e-06	5.5	5.5	3.2e-08	-0.52	0.94	0.04	FALSE
4	GTEx	Brain Hippocampus	NPIPA3	0.26	0.00	lasso	12	0.01	1.5e-01	3.2	5.5	4.4e-08	-0.41	0.02	0.50	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	RRN3	0.36	0.14	lasso	5	0.20	4.5e-07	5.5	5.8	5.6e-09	-0.64	0.19	0.76	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	RP11-958N24.1	0.22	0.02	lasso	5	0.06	4.8e-03	-2.9	5.2	2.3e-07	-0.62	0.02	0.35	FALSE
7	GTEx	Cells Transformed fibroblasts	RRN3	0.10	0.12	enet	13	0.13	6.3e-10	5.5	6.3	3.6e-10	-0.61	0.72	0.28	FALSE
8	GTEx	Esophagus Mucosa	RRN3	0.13	0.13	lasso	4	0.13	3.2e-09	5.3	5.4	8.2e-08	-0.55	0.91	0.08	FALSE
9	GTEx	Heart Atrial Appendage	NTAN1	0.10	0.09	lasso	1	0.07	3.7e-04	5.3	5.3	9.1e-08	-0.52	0.04	0.45	FALSE
10	GTEx	Heart Left Ventricle	NTAN1	0.09	0.04	lasso	3	0.02	2.0e-02	5.5	5.2	1.8e-07	-0.51	0.02	0.71	FALSE
11	GTEx	Muscle Skeletal	NTAN1	0.12	0.07	lasso	6	0.09	1.4e-09	5.3	5.7	9.8e-09	-0.48	0.95	0.04	FALSE
12	GTEx	Skin Sun Exposed Lower leg	RRN3	0.10	0.12	lasso	1	0.11	4.5e-09	5.5	5.5	3.0e-08	-0.52	0.93	0.07	FALSE
13	GTEx	Testis	RRN3	0.10	0.10	lasso	2	0.07	3.9e-04	5.5	5.5	3.0e-08	-0.52	0.12	0.14	FALSE
14	NTR	Blood	NTAN1	0.01	0.00	bslmm	110	0.00	4.2e-02	5.5	5.3	1.2e-07	-0.25	0.02	0.03	FALSE
15	NTR	Blood	PDXDC1	0.12	0.12	enet	26	0.15	1.3e-46	-7.1	7.2	5.7e-13	-0.88	0.01	0.99	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	NTAN1	0.12	0.10	lasso	3	0.11	1.4e-13	5.3	5.2	1.9e-07	-0.51	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	RP11-958N24.1	0.07	0.01	enet	7	0.02	1.9e-03	5.3	5.2	2.3e-07	-0.47	0.43	0.09	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	NPIPA2	0.48	0.26	bslmm	145	0.47	2.1e-68	2.9	-6.0	1.6e-09	0.74	0.72	0.28	FALSE