Hub : Genes

NPIPA3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.504 0.0990 6.9e-06 0.041 NA 0.090 NA 0.035 2.3e-02 NA 1.3e-03 NA 3.4e-02
2 GTEx Brain Cortex 0.313 0.1050 8.2e-03 -0.006 NA 0.009 NA -0.003 5.2e-01 NA 1.8e-01 NA 4.1e-01
3 GTEx Brain Hippocampus 0.255 0.0914 3.7e-03 0.001 NA -0.013 NA 0.014 3.1e-01 NA 9.5e-01 NA 1.5e-01
4 GTEx Cells Transformed fibroblasts 0.160 0.0550 3.1e-04 0.104 NA 0.088 NA 0.115 3.3e-08 NA 4.0e-07 NA 5.9e-09
5 GTEx Esophagus Gastroesophageal Junction 0.529 0.0900 2.1e-05 0.186 NA 0.148 NA 0.207 2.7e-07 NA 5.0e-06 NA 5.2e-08
6 GTEx Skin Sun Exposed Lower leg 0.085 0.0370 5.6e-03 0.075 NA 0.045 NA 0.056 8.7e-07 NA 1.2e-04 NA 2.0e-05
7 ROSMAP Brain Pre-frontal Cortex 0.627 0.0424 0.0e+00 0.357 0.488 0.525 0.532 0.540 7.9e-48 1.5e-71 2.1e-79 7.1e-81 1.4e-82

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.5 1.6 1.1 1.3 0.1 -0.5 0.0 -0.1 -0.4
Bipolar Disorder or Schizophrenia 0.5 1.2 3.2 -0.1 0.2 -1.8 -1.7 -0.7 -1.3 -0.5
Depressed Affect (Nagel 2018) 0.4 0.9 3.8 -1.9 -0.5 -1.0 -0.4 0.1 0.3 -0.9
Depression (Nagel 2018) 0.2 0.3 1.0 -1.0 0.6 0.3 0.2 0.1 -0.1 -1.0
Intelligence (Savage-Jansen 2018) 0.7 2.2 7.0 -1.2 -2.3 -1.1 0.9 0.1 0.1 2.6
Neuroticism (Nagel 2018) 0.7 1.7 4.2 -2.0 -0.6 -1.8 -1.4 -0.8 -0.9 -0.9
Schizophrenia (2018) 0.8 1.6 5.4 -0.9 -0.8 -2.3 -1.4 -0.9 -1.3 -0.0
Schizophrenia vs Biploar Disorder 1.4 1.8 5.8 -1.5 -2.4 -1.7 0.0 0.0 0.1 1.4
Worry (Nagel 2018) 0.6 1.3 3.0 -1.6 -0.9 -1.7 -1.2 -0.9 -0.8 -0.6
Alzheimer’s Disease (in mother) 1.0 1.2 1.7 1.1 0.2 1.3 0.9 1.3 1.2 1.2
Alzheimer’s Disease (in father) 0.3 0.4 1.0 -0.4 0.5 0.3 1.0 0.3 0.2 0.9
Alzheimer’s Disease (including proxy) 0.8 1.2 2.8 0.6 1.3 1.7 0.9 1.0 0.8 1.0
Crohns Disease (2017) 0.7 1.6 5.1 -0.8 0.7 -0.6 -2.3 -1.5 -1.5 -0.8
Irritable Bowel Disease (IBD) 1.3 3.1 9.1 -1.4 0.3 -1.4 -3.0 -1.9 -1.6 -1.6
Ulcerative Colitis (UC) 1.2 2.2 6.8 -1.1 0.3 -1.2 -2.6 -1.5 -1.1 -1.4
Major Depression (MDD) 0.1 0.1 0.5 -0.5 0.4 0.0 -0.3 0.0 -0.1 -0.7
Reaction Time 0.2 0.4 0.6 -0.6 -0.8 -0.8 0.6 -0.3 0.2 0.7
Verbal and Numeric Reasoning (VNR) 0.8 1.9 5.0 0.4 -0.7 0.7 1.9 1.2 1.4 2.2
Breast Cancer 0.3 0.7 2.8 -0.1 -1.7 -0.9 0.8 0.4 0.2 0.7
Ovarian Cancer 0.3 0.4 0.9 0.4 0.9 -0.3 -0.4 -0.2 -0.9 -0.8
Prostate Cancer 0.8 1.1 3.3 -0.5 -1.5 -0.1 1.4 -0.1 0.5 1.8
Age at First Birth 0.7 1.0 2.1 -0.3 -1.0 -1.2 -0.8 -0.9 -0.8 1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.9 0.9 0.3 1.4 0.7 0.0 0.2 -0.6
Coronary Artery Disease (CAD) 0.3 0.3 0.8 -0.7 -0.9 -0.4 -0.5 0.0 0.7 0.1
Crohns Disease (2012) 1.4 2.3 5.3 -0.7 0.7 -1.1 -2.3 -2.0 -1.8 -1.1
Mean Putamen Volume 0.4 0.4 1.5 1.2 -0.0 0.9 0.7 0.4 0.2 -0.3
Fasting Glucose 0.3 0.3 0.9 -0.3 0.8 0.7 -0.1 -0.0 -0.2 -1.0
HbA1C 0.3 0.4 1.5 -0.3 1.2 0.2 -0.4 -0.7 -0.4 -0.3
HDL Cholesterol 0.6 1.0 2.9 1.1 -0.1 1.0 1.3 0.0 0.4 1.7
LDL Cholesterol 0.4 0.6 2.0 -0.2 1.1 -0.1 -0.8 0.0 -1.4 -0.7
Lupus 0.6 0.9 1.8 0.0 0.3 1.3 1.4 0.9 1.1 0.6
Neuroticism (2016) 2.2 3.2 6.2 -2.5 -2.4 -2.5 -1.6 -0.8 -0.4 -0.9
Primary Biliary Cirrhosis 1.9 2.7 5.5 -2.1 -2.0 -2.3 -1.2 0.0 -0.9 -1.8
Rheumatoid Arthritis 0.3 0.4 1.5 -0.4 -0.8 -0.5 -0.5 0.0 -1.2 -0.4
Schizophrenia (2014) 3.7 8.1 16.3 -2.1 -1.4 -4.0 -3.6 -3.2 -3.1 -1.5
Triglycerides 0.6 1.0 3.0 -1.0 1.2 -0.7 -1.7 0.0 0.3 -1.2
Type 2 Diabetes (T2D) (2012) 0.9 1.1 3.6 1.9 1.2 0.9 -0.5 0.0 -0.4 -1.2
Ulcerative Colitis 1.0 1.5 4.3 -0.6 0.0 -1.0 -2.1 -1.4 -1.2 -1.2
Blood Eosinophil Count 0.1 1.1 2.8 1.0 1.0 1.7 0.3 -1.3 -1.1 0.4
Blood Platelet Count 0.2 2.7 5.6 -1.6 -1.7 -1.3 1.0 2.4 2.3 0.1
Blood Red Count 0.1 1.0 2.8 -1.5 0.1 -0.6 -0.3 1.2 1.7 0.2
Blood White Count 0.1 0.6 1.8 -0.4 -0.1 0.1 0.4 1.2 0.9 -1.3
Heel T-Score 0.1 0.8 2.0 -0.4 0.0 -1.1 -1.4 1.0 0.8 -0.8
BMI 0.1 0.6 1.8 -0.2 -1.0 -0.1 1.1 0.5 -0.1 -1.3
Height 0.5 8.8 31.5 3.0 2.8 5.6 2.7 2.0 1.0 -1.1
Waist Hip Ratio (WHR) 0.1 0.6 1.2 -1.1 -0.8 -1.0 0.2 0.6 0.7 -0.6
Systolic Blood Pressure 0.3 1.4 2.6 -1.0 0.3 -1.2 -1.6 -1.2 -0.9 -1.6
Smoking Status 0.1 0.2 0.7 -0.9 0.1 0.2 -0.1 0.2 0.6 0.1
Allergy or Eczema 0.5 1.3 4.3 1.4 0.9 1.1 0.5 -0.5 0.0 2.1
Cardiovascular Disease 0.3 0.9 1.9 -1.4 -0.5 -1.1 -0.7 -0.6 -0.9 -1.3
Hypothyroidism (self reported) 0.2 0.5 1.6 -0.2 -0.9 -0.1 -0.5 0.8 1.3 0.3
Respiratory disease 0.3 0.7 2.0 -0.7 -0.2 -0.3 -0.1 -1.4 -1.0 1.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.6 -0.7 -1.4 -1.3 -0.6 0.4 0.1 -1.6
Lung FEV1/FVC ratio 0.1 0.6 2.4 0.3 0.4 0.2 -0.4 -1.1 -1.6 -0.2
Lung FVC 0.4 1.9 3.9 1.5 0.9 1.0 1.1 1.8 2.0 0.9
Neuroticism 0.9 2.2 4.2 -2.0 -0.6 -2.0 -1.8 -1.3 -1.2 -0.7
Chronotype (morning person) 0.2 0.5 1.6 1.3 1.0 0.6 0.5 -0.2 -0.4 -0.2
Hair Pigment 0.0 1.0 2.4 0.9 0.7 1.0 0.7 1.6 1.1 -0.7
Tanning 0.1 0.7 1.3 0.5 -0.5 1.0 1.0 1.1 1.1 0.2
Hand grip strength (left) 0.4 1.0 4.1 1.3 0.6 2.0 1.0 0.2 0.1 -0.1
Number of treatments/medications taken 1.0 1.7 3.9 -1.6 -1.8 -2.0 -0.7 -0.3 -0.8 -1.2
Average weekly spirits intake 0.3 0.4 2.2 -1.5 -0.7 0.1 0.1 -0.3 -0.1 0.0
Sensitivity / hurt feelings 0.3 0.6 2.2 -1.5 -0.7 -1.2 -0.1 -0.1 -0.1 -0.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.0 -1.0 0.3 -0.2 -0.7 -0.7 -0.6 -0.7
Hearing difficulty/problems: Yes 1.1 1.7 7.1 -0.7 -2.7 -1.2 0.9 0.9 0.8 -0.7
Relative age of first facial hair 0.9 1.9 8.6 0.4 2.9 0.7 -1.2 -0.0 -0.2 -1.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.7 0.8 0.7 -0.1 0.2 -0.0 0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 -0.1 0.6 0.7 -0.8 -0.0 0.2 -0.5
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 -0.6 -1.1 -0.1 0.5 0.5 0.8 1.1
Systolic blood pressure, automated reading 0.7 2.1 4.4 -1.4 0.4 -1.3 -1.6 -1.3 -1.4 -2.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 5.3 -0.1 -2.3 -1.4 -0.1 0.6 0.2 -0.7
Angina 1.4 1.9 4.0 -1.9 -1.1 -0.1 1.0 1.5 2.0 1.1
Medication for hormone replacement therapy 1.2 1.3 3.4 -0.1 -0.7 -0.7 -1.7 -1.8 -1.5 -0.4
Vitamin and mineral supplements 0.3 0.4 0.8 -0.3 0.7 0.4 0.5 0.9 0.7 -0.4
Supplements: Zinc 0.4 0.4 1.0 -0.9 -1.0 -0.7 -0.1 -0.7 -0.2 -0.0
Medication: Co-codamol 0.4 0.5 1.3 -1.0 0.1 -0.6 -0.4 0.1 -0.5 -1.1
Medication: Metformin 0.5 0.7 1.4 -0.7 -1.2 -0.4 0.9 1.0 1.1 -0.4
Diabetes (father) 2.2 2.7 6.0 0.5 0.1 -1.0 -2.1 -1.8 -2.1 -2.4
Diabetes (mother) 0.8 1.0 3.7 -0.1 1.3 0.5 -0.7 -0.4 -0.7 -1.9
Severe depression (siblings) 0.2 0.2 1.0 1.0 -0.3 0.1 0.4 -0.3 0.1 0.5
Pack years adult smoking proportion 1.6 2.4 4.8 -2.2 -1.7 -2.1 -1.0 -0.4 -0.9 -1.7
Impedance of leg (right) 0.3 1.4 3.5 -0.7 0.6 -1.0 -1.9 -0.8 -1.1 -1.5
Leg fat-free mass (left) 0.4 2.3 7.2 1.9 1.2 2.7 1.6 0.7 0.6 0.0
Trunk fat percentage 0.4 1.4 7.2 0.3 0.8 0.3 -0.7 -0.4 -1.1 -2.7
Hand grip strength (right) 0.8 2.2 5.8 2.0 1.1 2.4 1.4 0.9 0.8 0.8
Townsend deprivation index at recruitment 0.9 1.3 2.9 -1.6 -0.8 -1.7 -1.4 -0.8 -0.4 -0.5
Current tobacco smoking 0.2 0.4 1.3 -1.1 -0.9 -0.5 0.1 0.1 0.4 -0.6
Average weekly fortified wine intake 2.9 3.4 10.5 -1.8 -3.2 -2.3 1.2 0.6 0.5 1.8
Maternal smoking around birth 0.5 0.7 1.7 0.1 0.4 1.1 0.7 1.3 1.2 -0.1
Fed-up feelings 0.6 1.2 5.4 -2.3 -1.2 -1.0 -0.0 0.4 0.6 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.8 -0.6 0.9 0.7 -0.1 -0.1 -0.3 -0.9
Relative age voice broke 0.6 0.9 2.3 -1.2 0.5 -0.7 -1.0 -0.3 -0.5 -1.5
Taking other prescription medications 0.8 1.2 2.9 -1.7 -1.2 -1.2 -0.7 -0.4 -0.6 -1.4
Age when periods started (menarche) 0.9 2.2 5.0 0.4 2.2 -0.4 -1.9 -0.6 -1.5 -2.0
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.4 -0.7 -1.2 -1.0 -0.9 -0.0 0.4 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 0.6 -0.0 -0.1 0.3 1.0 1.1 0.6
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.6 1.6 0.4 1.0 0.8 1.6 1.4 0.3
Qualifications: CSEs or equivalent 1.2 1.6 4.2 1.5 0.8 2.0 1.0 1.4 1.1 0.4
Serious illness, injury or assault to yourself 0.3 0.3 1.0 -0.6 -1.0 -0.3 0.3 0.7 0.0 -0.6
High blood pressure 0.6 1.7 7.3 -2.7 -0.7 -1.2 -0.4 -0.1 -0.4 -1.5
Hayfever, allergic rhinitis or eczema 0.6 1.2 3.2 1.8 0.7 1.2 0.6 -0.1 0.2 1.8
Multivitamins +/- minerals 0.4 0.5 2.1 -0.1 -1.4 -0.6 -0.3 -0.6 -0.3 0.6
Stomach or abdominal pain in last month 3.1 3.9 8.3 -2.9 -2.9 -2.7 -0.8 -0.7 -0.7 -1.4
Supplements: Glucosamine 0.5 0.7 1.5 -0.3 -1.2 -1.0 -0.5 -0.1 -0.6 -1.2
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.5 -0.9 -0.9 -0.3 1.2 1.2 0.9 1.2
Medication: Atenolol 0.4 0.5 3.1 -1.8 0.3 -0.3 -0.0 -0.2 0.3 -0.4
Medication: Levothyroxine sodium 0.4 0.7 1.8 0.7 -0.2 0.4 0.3 1.3 1.4 0.6
Sitting height 1.7 12.0 29.9 4.3 3.0 5.5 3.6 2.0 2.2 2.1
Chronic bronchitis/emphysema (father) 0.1 0.2 0.4 -0.6 -0.0 -0.5 0.3 0.6 -0.0 -0.3
High blood pressure (mother) 1.0 1.4 2.4 -0.9 -0.7 -1.5 -1.5 -1.5 -1.2 -0.1
Body mass index (BMI) 0.1 0.4 2.2 0.1 0.2 0.3 0.5 0.2 -0.1 -1.5
Impedance of leg (left) 0.2 1.1 2.9 -0.3 0.8 -0.7 -1.7 -0.8 -1.1 -1.3
Leg predicted mass (left) 0.4 2.1 7.0 1.9 1.1 2.6 1.6 0.7 0.5 0.0
Trunk fat mass 0.3 1.3 5.9 0.7 1.0 0.9 0.0 -0.1 -0.8 -2.4
Waist circumference 0.2 0.6 1.8 -0.0 0.5 0.5 0.9 0.8 0.5 -1.4
Number of incorrect matches in round 0.7 1.1 2.2 -0.9 -1.3 -1.1 0.6 1.5 1.2 -0.2
Past tobacco smoking 0.5 0.9 1.9 1.1 0.5 0.1 -0.7 -1.1 -1.4 -1.2
Alcohol usually taken with meals 0.8 1.3 6.2 0.6 -1.2 -0.1 1.1 0.2 0.4 2.5
Nervous feelings 0.1 0.2 0.5 -0.4 -0.2 -0.3 0.4 0.4 0.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.7 -1.6 -0.3 -1.4 -1.5 -0.9 -0.7 -0.8
Hearing difficulty/problems with background noise 0.7 1.1 2.8 0.2 -1.4 0.4 0.9 1.1 1.7 0.9
Hair/balding pattern: Pattern 2 2.1 2.7 6.6 2.5 2.2 2.6 0.7 0.2 0.3 0.6
Had menopause 0.7 0.9 2.1 -1.1 -1.4 -0.5 1.0 0.6 0.7 1.0
Had other major operations 0.4 0.5 2.0 -0.2 -0.2 0.0 0.2 0.9 1.4 0.7
Forced vital capacity (FVC) 1.6 6.3 13.9 3.7 2.6 3.6 1.7 1.8 1.8 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 0.4 0.1 -0.5 -0.5 0.3 0.6 0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.5 -0.3 -0.3 -0.6 -0.2 -0.0 -0.5 -1.2
Qualifications: None of the above 0.8 1.8 5.9 -1.7 -0.6 -1.2 -0.3 1.3 0.7 -2.4
Financial difficulties in last 2 years 0.4 0.5 2.1 -0.5 -1.5 -0.9 -0.4 -0.0 0.1 0.1
Mouth/teeth dental problems 4.6 7.1 15.4 3.5 3.8 3.9 1.5 1.2 0.9 1.8
Heart attack 2.0 2.6 6.0 -0.2 1.3 1.6 1.4 2.4 2.4 0.7
Allergy 0.7 1.7 4.8 -1.3 -0.0 -1.5 -1.6 -0.4 -0.5 -2.2
Pain all over the body in last month 0.9 0.9 3.0 -0.1 0.6 0.4 1.2 1.1 1.7 0.4
Diabetes (self-reported) 0.3 0.5 1.1 -0.7 -1.0 -0.6 0.4 0.8 0.9 -0.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.1 1.0 1.1 0.7 0.2 -0.8 -0.5 0.7
Medication: Ramipril 0.8 1.1 3.1 -0.8 0.2 0.7 1.0 1.8 1.5 0.1
Medication: Simvastatin 0.6 0.9 3.6 -1.9 -1.0 -0.6 0.6 0.5 0.5 0.8
Fluid intelligence score 1.6 3.4 8.5 1.4 -0.8 1.1 2.3 1.4 2.1 2.9
Illnesses of siblings 0.3 0.4 1.2 1.1 0.2 0.3 0.3 -0.1 0.2 1.1
Neuroticism score 0.3 0.6 2.3 -1.5 -0.4 -1.2 -0.5 0.0 0.1 0.1
Weight 0.3 1.4 3.3 1.1 1.3 1.8 0.8 0.1 -0.3 -1.7
Impedance of arm (right) 0.1 0.5 1.5 0.5 0.0 -0.8 -1.2 -0.6 -1.0 -0.2
Arm fat percentage (right) 0.2 0.8 4.1 0.6 0.7 0.2 -0.0 0.0 -0.7 -2.0
Trunk fat-free mass 0.3 1.7 6.2 1.4 1.1 2.5 1.5 0.3 0.1 -0.2
Hip circumference 0.2 0.8 1.5 0.8 1.1 1.2 1.1 0.4 0.0 -0.8
Time employed in main current job 0.2 0.2 1.0 0.4 1.0 0.3 0.5 0.2 -0.2 0.2
Alcohol intake versus 10 years previously 1.4 2.1 5.2 -0.4 1.7 -0.5 -2.3 -1.5 -1.1 -1.6
Father’s age at death 0.1 0.1 0.3 0.2 -0.5 -0.5 0.0 0.4 0.4 0.3
Worrier / anxious feelings 0.6 1.1 3.5 -1.0 -0.8 -0.6 0.7 0.6 1.0 1.9
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.1 -0.4 -0.4 -1.0 -1.1 -1.0 -1.0 -0.5
Falls in the last year 0.3 0.4 1.0 -0.2 -1.0 -0.7 0.4 0.7 0.8 -0.0
Hair/balding pattern: Pattern 3 1.9 2.8 4.6 -2.0 -1.4 -2.1 -1.0 -1.3 -1.6 -2.1
Number of live births 0.7 1.0 3.0 -0.2 1.4 0.8 -1.3 -0.1 0.1 -1.7
Forced expiratory volume in 1-second (FEV1) 1.7 5.7 14.4 3.8 2.7 3.4 1.3 1.5 1.3 0.9
Pulse rate 0.3 0.4 1.6 0.4 1.3 0.7 -0.4 0.5 0.5 -0.6
Happiness 1.9 2.3 6.7 1.4 -0.2 1.1 2.6 1.8 1.3 1.1
Noisy workplace 2.7 3.3 6.6 -2.6 -2.6 -1.9 1.1 1.6 0.7 -1.4
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.7 -0.4 -1.4 -0.1 0.4 -0.6 0.0 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.2 -0.1 -0.6 -0.4 0.7 1.2 1.0 1.8
Mouth/teeth dental problems: Dentures 3.1 5.2 10.4 -3.2 -3.2 -3.2 -1.1 -1.4 -1.2 -1.3
Asthma 0.8 1.7 6.4 -0.2 -1.4 -0.2 1.8 0.1 0.3 2.5
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.5 0.6 1.1 1.2 0.9 0.3 -0.1 0.3
Medication: Cholesterol lowering 0.2 0.3 0.8 -0.9 0.5 0.4 0.7 0.0 0.3 0.6
Depression (self-reported) 0.9 1.1 2.7 -0.7 -0.5 -0.9 -1.6 -1.3 -0.9 -0.8
Medication: Lansoprazole 0.7 0.8 3.7 0.1 1.9 1.3 -0.2 0.2 0.5 -0.3
Prospective memory result 0.6 0.7 1.6 -1.3 -0.1 -0.7 -1.0 -0.4 -0.8 -1.1
Lung cancer (father) 0.3 0.3 0.8 -0.6 0.2 0.1 -0.1 -0.9 -0.9 -0.6
Illnesses of mother 0.6 0.7 1.6 1.3 0.4 1.1 1.2 0.4 0.3 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 9.5 3.1 1.8 2.5 0.7 1.2 0.9 0.2
Pulse wave Arterial Stiffness index 2.2 2.6 6.1 0.6 -1.2 0.1 2.0 2.5 2.4 0.6
Impedance of arm (left) 0.1 0.6 2.1 0.4 0.4 -0.4 -1.4 -0.7 -1.0 -0.3
Arm fat mass (right) 0.2 0.8 3.2 1.1 0.7 0.8 0.5 0.3 -0.3 -1.8
Trunk predicted mass 0.3 1.7 6.4 1.4 1.1 2.5 1.5 0.3 0.1 -0.1
Standing height 0.4 3.7 12.7 2.3 2.5 3.6 0.6 -0.4 -0.7 -1.0
Length of working week for main job 0.6 0.6 1.6 0.5 -1.2 0.5 0.9 -0.1 -0.1 1.3
Exposure to tobacco smoke at home 1.4 1.5 4.3 -0.2 -0.8 -0.3 1.6 2.1 1.7 0.4
Breastfed as a baby 0.4 0.5 1.2 -0.7 0.2 -0.3 -0.0 -0.6 -1.1 -1.0
Tense / ‘highly strung’ 0.6 0.9 3.0 -1.7 -0.5 -1.5 -0.9 0.1 0.0 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.7 -1.8 0.4 -0.8 -1.9 -1.9 -1.2 -0.5
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 0.2 -1.0 -0.3 -0.5 -0.8 -0.9 -0.2
Birth weight of first child 0.3 0.6 1.3 0.9 -1.1 -0.2 -0.0 -1.1 -0.8 0.1
Peak expiratory flow (PEF) 2.3 5.2 11.4 3.4 2.3 3.4 1.5 1.0 1.0 2.1
Pulse wave reflection index 1.8 2.2 4.1 0.4 -2.0 -0.4 1.7 1.6 1.8 1.5
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.6 -0.8 -1.0 -1.2 0.2 0.5 0.3 -1.2
Loud music exposure frequency 0.3 0.3 0.8 -0.0 -0.3 0.1 0.9 0.7 0.7 -0.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.3 1.1 -0.1 0.4 -0.4 -1.0 -0.6 0.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.8 -0.1 -0.7 -0.1 0.2 0.8 0.9 -0.2
Blood clot in the leg (DVT) 0.5 0.6 2.4 0.2 1.1 1.5 -0.3 -0.4 -0.4 -0.1
Medication: Paracetamol 1.3 2.1 5.3 -1.9 -1.2 -1.6 -1.0 -0.1 -1.0 -2.3
Headache pain in last month 3.3 5.6 9.2 -1.9 -1.0 -2.7 -2.8 -3.0 -2.9 -1.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.4 -0.3 -1.2 -0.8 -0.9 -0.7 -0.3 -0.3
Glaucoma (self-reported) 0.2 0.3 0.6 0.2 -0.8 -0.5 -0.6 -0.2 -0.5 -0.6
Gout (self-reported) 0.5 0.7 1.2 -0.3 1.0 1.1 1.1 0.8 0.8 0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.1 0.5 -0.3 0.3 0.3 1.3 1.4 0.7
Medication: Amlodipine 0.2 0.3 1.1 -0.0 -0.1 0.0 0.5 1.1 0.8 0.2
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.7 -0.2 -1.7 -1.1 1.3 0.3 -0.0 0.8
Birth weight 0.2 0.5 1.4 0.6 -0.9 0.6 1.2 0.8 0.5 0.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.8 -1.4 0.1 -0.6 -0.4 -0.6 -0.2 -0.9
High blood pressure (siblings) 0.4 0.6 2.7 -1.6 -0.6 -0.6 -0.4 -0.7 -0.3 -0.2
Forced vital capacity (FVC), Best measure 1.0 3.5 9.6 3.1 1.4 2.7 1.1 1.4 1.5 0.6
Body fat percentage 0.4 1.4 7.4 0.2 0.9 0.1 -0.7 -0.4 -1.1 -2.7
Leg fat percentage (right) 0.3 1.2 7.0 -0.4 0.8 -0.4 -0.3 0.1 -0.6 -2.6
Arm fat-free mass (right) 0.4 2.0 7.7 1.4 1.6 2.8 1.1 0.3 0.3 -0.5
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.4 -0.2 -0.8 -0.6 -0.4 -0.4 -0.5
Comparative body size at age 10 0.1 0.2 0.6 -0.7 0.1 0.5 0.8 -0.1 0.0 0.2
Number of full brothers 0.3 0.3 1.8 -1.4 -0.0 -0.5 0.3 0.1 0.4 0.2
Worry too long after embarrassment 0.1 0.2 1.3 0.1 0.1 -0.6 0.1 -0.2 -0.0 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.5 -1.1 -1.6 -1.0 -0.7 -1.0 -0.4 0.4
Wheeze or whistling in the chest in last year 0.2 0.3 0.7 0.2 -0.7 -0.7 -0.2 -0.5 -0.8 -0.2
Number of children fathered 0.3 0.4 1.3 -0.2 0.2 0.5 0.7 1.1 0.7 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 0.8 0.8 0.4 -0.2 -0.5 -0.5 -0.2
Age at first live birth 0.4 0.7 1.2 1.0 0.7 0.8 0.8 -0.7 -1.1 0.7
Pulse wave peak to peak time 2.5 2.9 6.7 -0.5 1.4 0.1 -2.1 -2.6 -2.6 -0.9
Health satisfaction 0.4 0.6 2.2 -1.0 -0.6 -0.4 -0.1 -0.1 -0.4 -1.5
Shortness of breath walking on level ground 1.4 1.6 3.6 -1.4 -1.4 -1.6 -0.7 -0.3 -0.8 -1.9
Qualifications: College or University degree 0.6 2.0 11.2 0.9 -0.1 0.6 1.1 -0.3 0.2 3.3
Eye problems/disorders: None of the above 3.1 3.6 8.9 1.0 1.1 1.5 1.9 1.6 2.4 3.0
Mouth/teeth dental problems: Loose teeth 5.7 6.7 9.4 -3.1 -2.1 -2.9 -2.6 -2.1 -2.1 -3.0
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.3 -0.6 -0.0 -0.3 -0.1 -0.4 -0.4
Medication for pain relief, constipation, heartburn 1.1 1.8 5.5 2.2 0.2 1.0 0.7 0.3 1.0 2.3
Neck or shoulder pain in last month 0.5 0.7 2.5 -1.6 -0.5 -1.0 -0.5 -0.5 -0.5 -0.6
Medication: Blood pressure 0.2 0.3 0.7 -0.1 0.8 0.2 0.8 0.7 0.3 0.1
Angina (self-reported) 1.4 1.8 4.1 -1.8 -0.9 0.1 0.9 1.5 2.0 1.2
Migraine (self-reported) 0.9 1.1 3.7 0.8 1.9 0.5 -0.6 -1.2 -1.0 0.1
Medication: Ibuprofen 1.2 1.4 2.9 1.1 1.1 1.7 1.4 1.1 0.9 0.8
Medication: Allopurinol 0.2 0.2 0.7 -0.6 -0.6 -0.1 0.3 0.1 0.2 0.8
Medication: Omeprazole 0.6 0.8 2.0 -1.4 -0.7 -1.2 -0.5 0.3 0.1 -1.1
Medication: Seretide 50 evohaler 0.3 0.3 0.5 -0.7 -0.7 -0.7 -0.4 -0.6 -0.7 -0.0
Mean time to correctly identify matches 0.3 0.5 1.3 -0.6 -1.0 -1.1 0.3 -0.6 -0.2 0.6
Heart disease (mother) 1.2 1.5 2.9 -1.7 0.1 -1.1 -1.7 -1.4 -0.9 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.0 0.4 1.0 -0.4 -0.3 -0.4 -0.7 -0.3
Whole body fat mass 0.3 1.3 5.9 0.8 1.1 0.9 0.0 -0.2 -0.8 -2.4
Leg fat mass (right) 0.2 0.9 4.0 0.5 1.0 0.8 0.6 0.5 -0.1 -2.0
Arm predicted mass (right) 0.4 1.9 7.1 1.5 1.5 2.7 1.1 0.2 0.2 -0.5
Pulse rate, automated reading 0.2 0.7 1.8 -0.8 0.8 -0.7 -1.3 -0.5 -0.0 -0.8
Alcohol intake frequency. 0.4 0.8 2.3 1.0 1.5 0.1 -0.6 -0.5 -0.9 -1.1
Comparative height size at age 10 0.2 0.9 2.4 1.5 0.1 1.6 0.2 -0.1 -0.8 -1.0
Number of full sisters 0.6 0.7 1.4 -1.2 -1.1 -0.2 0.3 1.0 1.0 -0.7
Suffer from ‘nerves’ 0.6 0.9 2.0 -0.8 -0.8 -1.4 -1.3 -0.3 -0.5 -0.9
Overall health rating 0.5 1.1 2.5 -1.4 -1.3 -1.0 0.2 0.4 -0.1 -1.6
Chest pain or discomfort 0.1 0.1 0.4 -0.4 0.1 -0.0 -0.2 0.0 -0.1 -0.6
Had major operations 0.3 0.3 1.4 -0.4 -1.2 -0.8 0.1 0.3 0.0 0.0
Age at last live birth 0.5 0.8 1.6 0.6 1.2 0.6 -0.5 -1.0 -1.3 -0.7
Family relationship satisfaction 0.3 0.4 0.9 -0.0 -1.0 -0.6 0.4 0.9 0.5 -0.3
Leg pain on walking 1.1 1.3 2.9 -1.0 -1.7 -1.6 0.0 1.1 0.2 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.5 0.7 1.6 1.0 -0.5 -0.0 -0.3 -1.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.3 -1.1 0.1 0.5 1.2 1.5 0.6 -0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.7 0.9 0.6 0.6 0.5 0.5 0.6 -0.1
Medication: Aspirin 0.6 0.8 3.7 -1.9 -0.1 -0.4 0.3 0.6 0.7 -0.8
Supplements: Vitamin C 0.7 0.8 2.4 -0.9 -1.6 -1.1 -0.4 -0.7 -0.6 -0.3
Knee pain experienced in last month 0.5 0.8 3.2 -0.3 -0.1 -0.8 -1.1 -0.6 -0.5 -1.8
Hypertension (Self-reported) 0.5 1.5 6.2 -2.5 -0.5 -1.1 -0.5 -0.0 -0.2 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 0.2 0.2 0.4 0.8 0.4 0.6 -0.0
Illnesses of father: Heart disease 0.3 0.4 0.9 0.2 -0.8 -0.2 -0.9 -0.7 -0.4 -0.9
Illnesses of siblings: Diabetes 0.3 0.3 0.8 0.6 0.6 0.9 -0.3 0.6 0.6 0.3
Smoking status: Previous 0.5 0.8 2.0 -0.4 0.3 0.6 0.8 1.0 1.2 1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 9.2 2.3 1.9 3.0 1.8 0.8 0.9 1.2
Whole body fat-free mass 0.4 2.1 7.2 1.8 1.2 2.7 1.5 0.4 0.3 -0.0
Leg fat-free mass (right) 0.5 2.8 8.5 2.3 1.3 2.9 1.8 0.7 0.7 0.3
Arm fat percentage (left) 0.2 0.7 3.5 0.6 0.7 0.3 -0.1 -0.0 -0.7 -1.9
Average weekly red wine intake 3.4 5.0 10.4 1.6 1.5 3.0 2.1 1.5 2.0 3.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.3 0.9 0.2 0.3 0.3 1.5 0.7 -0.4
Mood swings 0.1 0.2 0.7 -0.9 0.1 -0.5 -0.3 0.0 0.3 -0.0
Loneliness, isolation 1.7 2.3 5.9 -2.4 -2.1 -1.5 0.9 0.5 1.0 1.2
Long-standing illness, disability or infirmity 0.6 0.9 1.9 -1.1 -1.3 -1.4 -0.4 -0.2 -0.4 -1.0
Ever had bowel cancer screening 0.4 0.5 2.2 -0.2 0.1 -0.7 -0.7 0.3 -0.6 -1.5
Diabetes diagnosed by doctor 0.4 0.7 2.0 -0.9 -1.4 -0.7 0.3 0.7 0.9 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.6 0.1 1.2 0.6 -0.6 -0.1 0.5 -0.1
Friendships satisfaction 0.8 1.0 2.4 0.3 0.1 0.8 1.6 1.5 1.1 0.8
Qualifications: nursing, teaching 0.8 1.3 2.7 0.3 1.3 0.9 -0.8 -1.6 -0.6 1.6
Commuting to job workplace: Walk 0.4 0.4 1.1 1.0 -0.3 -0.5 -0.7 0.2 0.0 -1.0
Eye problems/disorders: Cataract 4.4 5.1 12.8 -1.2 0.5 -0.5 -2.7 -2.4 -2.8 -3.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.4 -1.1 -0.6 -1.2 -0.2 -0.3 -0.1 -0.2
Medication for cholesterol 0.8 1.2 2.0 1.1 1.0 1.0 1.4 1.0 0.8 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 8.9 0.3 0.6 -0.1 -0.9 -1.2 -1.8 -3.0
Back pain experienced in last month 0.5 0.8 2.8 -1.7 -0.1 -0.1 0.2 1.0 1.1 -0.4
Mineral and other dietary supplements 0.4 0.5 1.6 0.7 1.3 1.1 0.3 -0.0 0.3 0.3
Breast cancer (self-reported) 1.2 1.4 2.9 -1.7 0.6 -1.0 -1.7 -1.2 -1.0 -0.8
Asthma (self-reported) 0.7 1.3 4.7 -0.3 -1.4 -0.3 1.5 0.0 0.1 2.2
Osteoporosis (self-reported) 0.7 0.8 1.7 0.0 -1.2 -1.0 1.3 0.1 -0.0 1.2
Osteoarthritis (self-reported) 0.4 0.5 1.6 -1.0 -0.7 -1.3 -0.6 -0.4 0.2 -0.4
Medication: Aspirin 0.7 0.9 4.7 -2.2 -0.3 -0.3 0.4 0.8 0.7 -0.7
Medication: Gliclazide 0.4 0.5 1.6 -0.7 -1.3 -0.6 0.1 0.2 0.3 -0.8
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 -0.2 -0.5 -0.4 -0.6 -0.3 0.0 0.1
Smoking status: Current 0.3 0.5 1.8 -1.3 -0.8 -0.6 -0.1 -0.0 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.6 0.2 -0.4 -0.1 0.4 0.6 0.8 0.4
Whole body water mass 0.4 2.0 7.0 1.7 1.2 2.6 1.6 0.4 0.3 -0.1
Leg predicted mass (right) 0.5 2.7 8.4 2.3 1.3 2.9 1.7 0.7 0.6 0.3
Arm fat mass (left) 0.2 0.9 3.4 1.0 0.8 0.9 0.3 -0.0 -0.5 -1.9
Number of self-reported non-cancer illnesses 0.7 1.2 3.7 -1.8 -1.9 -1.2 0.2 0.1 0.2 0.4
Average weekly champagne plus white wine intake 2.3 3.1 7.0 -0.4 -0.8 -1.5 -1.6 -2.5 -2.7 -1.7
Miserableness 0.6 1.1 3.4 -1.8 -0.7 -1.1 -0.7 0.0 -0.3 -1.4
Guilty feelings 0.3 0.5 0.9 -0.9 0.4 -0.8 -0.7 -0.8 -0.8 0.3
Wears glasses or contact lenses 0.7 0.8 2.7 -1.7 -1.1 -1.1 -0.0 0.1 0.4 0.5
Ever taken oral contraceptive pill 0.5 0.5 2.1 -0.8 0.6 0.5 -1.5 -0.5 0.0 -0.2
Hearing aid user 0.6 0.7 2.3 -0.7 -1.5 -1.3 0.1 -0.1 -0.1 -0.7
Mother’s age at death 0.3 0.4 0.7 -0.7 -0.7 -0.8 0.1 -0.5 -0.7 -0.3
Financial situation satisfaction 0.1 0.1 0.4 -0.4 -0.4 -0.0 -0.1 0.0 -0.2 -0.7
Tinnitus: Yes, now most or all of the time 0.6 0.6 2.9 -1.7 -0.7 -0.8 0.1 0.5 -0.3 -0.5
Commuting to job workplace: Public transport 1.9 2.2 5.5 2.3 0.9 1.4 1.1 0.8 1.3 1.9
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 0.7 -0.4 0.1 0.3 0.6 0.2 -0.1
Medication: Blood pressure 0.5 0.9 3.3 -1.8 -1.0 -0.9 -0.5 0.3 0.5 -0.7
Pain type(s) experienced in last month: Hip pain 1.3 1.7 3.9 -1.3 0.8 0.0 -1.2 -1.4 -1.5 -2.0
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.7 0.1 -0.4 0.1 0.5 0.8 0.7 0.8
High cholesterol (Self-reported) 1.6 2.9 6.0 -0.0 -0.9 0.3 2.5 2.0 2.2 2.0
Medication: Bendroflumethiazide 0.3 0.4 1.4 -1.2 0.1 -0.4 -0.4 0.0 -0.1 -0.9
Medication: Paracetamol 1.2 1.9 4.0 -1.5 -1.6 -1.6 -0.9 -0.3 -0.9 -2.0
Medication: Lisinopril 0.1 0.2 0.6 -0.6 -0.8 -0.2 0.4 0.1 0.2 -0.3
Medication: Atorvastatin 0.1 0.1 0.2 -0.2 0.5 0.3 0.1 0.5 0.4 -0.1
Illnesses of father: High blood pressure 0.5 0.6 2.3 1.0 1.5 0.9 -0.1 -0.2 -0.4 -0.1
Alcohol drinker status: Never 1.2 1.5 5.5 0.3 0.2 0.5 1.5 1.0 0.9 2.4
Ever smoked 0.4 0.6 1.2 -1.0 -0.6 -0.5 0.6 0.9 1.1 0.7
Basal metabolic rate 0.4 2.0 6.8 1.8 1.3 2.6 1.4 0.4 0.2 -0.4
Leg fat percentage (left) 0.3 1.1 6.6 0.0 0.9 -0.2 -0.2 0.2 -0.5 -2.6
Arm fat-free mass (left) 0.3 1.6 5.3 1.5 1.1 2.3 1.2 0.4 0.3 -0.5
Number of operations (self-reported) 0.1 0.1 0.3 -0.1 -0.5 0.2 -0.5 0.3 0.5 0.3
Average weekly beer plus cider intake 0.4 0.6 3.2 -0.6 0.6 -0.3 -0.5 0.1 0.1 -1.8
Irritability 3.1 5.2 9.7 -2.8 -0.3 -2.0 -2.7 -1.6 -2.3 -3.1
Risk taking 0.6 0.9 4.2 2.1 0.8 1.1 -0.0 0.4 -0.2 -0.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.2 -0.1 -0.7 -0.6 0.7 1.1 0.8 -0.5
Fractured/broken bones in last 5 years 0.3 0.3 1.3 0.3 -0.3 -0.1 0.8 0.2 0.5 1.1
Age started oral contraceptive pill 0.5 0.6 1.8 -1.3 -0.9 -1.3 -0.2 -0.2 0.0 0.3
Diastolic blood pressure, automated reading 0.6 1.8 5.7 0.9 2.4 0.7 -1.0 -0.5 -0.5 -2.1
Ever depressed for a whole week 0.5 0.7 2.2 1.2 1.5 0.3 -0.4 0.2 0.1 -0.8
Unable to work because of sickness or disability 0.2 0.3 0.7 -0.2 -0.4 -0.8 -0.8 -0.4 -0.1 -0.5
Commuting to job workplace: Cycle 1.5 1.8 6.8 0.7 -0.3 0.1 1.7 0.9 1.1 2.6
Myopia 0.5 0.8 1.8 1.4 0.2 0.6 0.9 1.1 1.0 0.3
Vascular/heart problems diagnosed by doctor 0.5 1.4 6.2 2.5 0.6 0.6 -0.5 -1.0 -0.7 0.8
Cholesterol lowering medication 0.6 0.9 1.5 -0.6 -1.1 0.2 1.0 1.2 1.2 0.9
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 4.9 -2.2 -0.6 -1.4 -0.8 -0.3 0.1 -0.8
Pain experienced in last month 1.9 3.2 5.2 2.3 0.1 2.0 1.9 1.6 1.5 2.2
Supplements: Calcium 2.6 2.8 6.6 -1.8 -2.6 -2.1 -1.1 -1.0 -1.4 -1.1
Basal cell carcinoma (self-reported) 2.3 2.8 7.2 1.1 -0.1 0.7 2.0 2.7 2.4 0.5
Heart attack/myocardial infarction (self-reported) 1.7 2.2 5.0 -0.2 1.3 1.5 1.2 2.2 2.2 0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.2 -0.1 1.0 1.5 -0.2 -0.1 -0.2 -0.1
Heart disease (siblings) 1.4 1.7 4.0 -2.0 -0.9 -1.6 -1.2 -0.7 -0.8 -1.5
Alcohol drinker status: Previous 0.7 0.8 1.7 0.2 -0.7 -1.2 -0.5 -1.2 -1.3 0.2
Pack years of smoking 2.2 3.3 7.6 -2.8 -2.1 -2.5 -1.1 -0.3 -0.9 -1.7
Impedance of whole body 0.2 0.9 3.0 0.1 0.8 -0.5 -1.7 -0.9 -1.1 -0.8
Leg fat mass (left) 0.2 0.9 3.6 0.6 0.9 0.8 0.7 0.6 -0.0 -1.9
Arm predicted mass (left) 0.3 1.5 5.0 1.5 1.3 2.2 1.0 0.0 -0.0 -0.7