Hub : Genes

NPIPA3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.504	0.0990	6.9e-06	0.041	NA	0.090	NA	0.035	2.3e-02	NA	1.3e-03	NA	3.4e-02
2	GTEx	Brain Cortex	0.313	0.1050	8.2e-03	-0.006	NA	0.009	NA	-0.003	5.2e-01	NA	1.8e-01	NA	4.1e-01
3	GTEx	Brain Hippocampus	0.255	0.0914	3.7e-03	0.001	NA	-0.013	NA	0.014	3.1e-01	NA	9.5e-01	NA	1.5e-01
4	GTEx	Cells Transformed fibroblasts	0.160	0.0550	3.1e-04	0.104	NA	0.088	NA	0.115	3.3e-08	NA	4.0e-07	NA	5.9e-09
5	GTEx	Esophagus Gastroesophageal Junction	0.529	0.0900	2.1e-05	0.186	NA	0.148	NA	0.207	2.7e-07	NA	5.0e-06	NA	5.2e-08
6	GTEx	Skin Sun Exposed Lower leg	0.085	0.0370	5.6e-03	0.075	NA	0.045	NA	0.056	8.7e-07	NA	1.2e-04	NA	2.0e-05
7	ROSMAP	Brain Pre-frontal Cortex	0.627	0.0424	0.0e+00	0.357	0.488	0.525	0.532	0.540	7.9e-48	1.5e-71	2.1e-79	7.1e-81	1.4e-82

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.6	1.1	1.3	0.1	-0.5	0.0	-0.1	-0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	3.2	-0.1	0.2	-1.8	-1.7	-0.7	-1.3	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	3.8	-1.9	-0.5	-1.0	-0.4	0.1	0.3	-0.9
Depression (Nagel 2018)	0.2	0.3	1.0	-1.0	0.6	0.3	0.2	0.1	-0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	7.0	-1.2	-2.3	-1.1	0.9	0.1	0.1	2.6
Neuroticism (Nagel 2018)	0.7	1.7	4.2	-2.0	-0.6	-1.8	-1.4	-0.8	-0.9	-0.9
Schizophrenia (2018)	0.8	1.6	5.4	-0.9	-0.8	-2.3	-1.4	-0.9	-1.3	-0.0
Schizophrenia vs Biploar Disorder	1.4	1.8	5.8	-1.5	-2.4	-1.7	0.0	0.0	0.1	1.4
Worry (Nagel 2018)	0.6	1.3	3.0	-1.6	-0.9	-1.7	-1.2	-0.9	-0.8	-0.6
Alzheimer’s Disease (in mother)	1.0	1.2	1.7	1.1	0.2	1.3	0.9	1.3	1.2	1.2
Alzheimer’s Disease (in father)	0.3	0.4	1.0	-0.4	0.5	0.3	1.0	0.3	0.2	0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	2.8	0.6	1.3	1.7	0.9	1.0	0.8	1.0
Crohns Disease (2017)	0.7	1.6	5.1	-0.8	0.7	-0.6	-2.3	-1.5	-1.5	-0.8
Irritable Bowel Disease (IBD)	1.3	3.1	9.1	-1.4	0.3	-1.4	-3.0	-1.9	-1.6	-1.6
Ulcerative Colitis (UC)	1.2	2.2	6.8	-1.1	0.3	-1.2	-2.6	-1.5	-1.1	-1.4
Major Depression (MDD)	0.1	0.1	0.5	-0.5	0.4	0.0	-0.3	0.0	-0.1	-0.7
Reaction Time	0.2	0.4	0.6	-0.6	-0.8	-0.8	0.6	-0.3	0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.0	0.4	-0.7	0.7	1.9	1.2	1.4	2.2
Breast Cancer	0.3	0.7	2.8	-0.1	-1.7	-0.9	0.8	0.4	0.2	0.7
Ovarian Cancer	0.3	0.4	0.9	0.4	0.9	-0.3	-0.4	-0.2	-0.9	-0.8
Prostate Cancer	0.8	1.1	3.3	-0.5	-1.5	-0.1	1.4	-0.1	0.5	1.8
Age at First Birth	0.7	1.0	2.1	-0.3	-1.0	-1.2	-0.8	-0.9	-0.8	1.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.9	0.9	0.3	1.4	0.7	0.0	0.2	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	0.8	-0.7	-0.9	-0.4	-0.5	0.0	0.7	0.1
Crohns Disease (2012)	1.4	2.3	5.3	-0.7	0.7	-1.1	-2.3	-2.0	-1.8	-1.1
Mean Putamen Volume	0.4	0.4	1.5	1.2	-0.0	0.9	0.7	0.4	0.2	-0.3
Fasting Glucose	0.3	0.3	0.9	-0.3	0.8	0.7	-0.1	-0.0	-0.2	-1.0
HbA1C	0.3	0.4	1.5	-0.3	1.2	0.2	-0.4	-0.7	-0.4	-0.3
HDL Cholesterol	0.6	1.0	2.9	1.1	-0.1	1.0	1.3	0.0	0.4	1.7
LDL Cholesterol	0.4	0.6	2.0	-0.2	1.1	-0.1	-0.8	0.0	-1.4	-0.7
Lupus	0.6	0.9	1.8	0.0	0.3	1.3	1.4	0.9	1.1	0.6
Neuroticism (2016)	2.2	3.2	6.2	-2.5	-2.4	-2.5	-1.6	-0.8	-0.4	-0.9
Primary Biliary Cirrhosis	1.9	2.7	5.5	-2.1	-2.0	-2.3	-1.2	0.0	-0.9	-1.8
Rheumatoid Arthritis	0.3	0.4	1.5	-0.4	-0.8	-0.5	-0.5	0.0	-1.2	-0.4
Schizophrenia (2014)	3.7	8.1	16.3	-2.1	-1.4	-4.0	-3.6	-3.2	-3.1	-1.5
Triglycerides	0.6	1.0	3.0	-1.0	1.2	-0.7	-1.7	0.0	0.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.6	1.9	1.2	0.9	-0.5	0.0	-0.4	-1.2
Ulcerative Colitis	1.0	1.5	4.3	-0.6	0.0	-1.0	-2.1	-1.4	-1.2	-1.2
Blood Eosinophil Count	0.1	1.1	2.8	1.0	1.0	1.7	0.3	-1.3	-1.1	0.4
Blood Platelet Count	0.2	2.7	5.6	-1.6	-1.7	-1.3	1.0	2.4	2.3	0.1
Blood Red Count	0.1	1.0	2.8	-1.5	0.1	-0.6	-0.3	1.2	1.7	0.2
Blood White Count	0.1	0.6	1.8	-0.4	-0.1	0.1	0.4	1.2	0.9	-1.3
Heel T-Score	0.1	0.8	2.0	-0.4	0.0	-1.1	-1.4	1.0	0.8	-0.8
BMI	0.1	0.6	1.8	-0.2	-1.0	-0.1	1.1	0.5	-0.1	-1.3
Height	0.5	8.8	31.5	3.0	2.8	5.6	2.7	2.0	1.0	-1.1
Waist Hip Ratio (WHR)	0.1	0.6	1.2	-1.1	-0.8	-1.0	0.2	0.6	0.7	-0.6
Systolic Blood Pressure	0.3	1.4	2.6	-1.0	0.3	-1.2	-1.6	-1.2	-0.9	-1.6
Smoking Status	0.1	0.2	0.7	-0.9	0.1	0.2	-0.1	0.2	0.6	0.1
Allergy or Eczema	0.5	1.3	4.3	1.4	0.9	1.1	0.5	-0.5	0.0	2.1
Cardiovascular Disease	0.3	0.9	1.9	-1.4	-0.5	-1.1	-0.7	-0.6	-0.9	-1.3
Hypothyroidism (self reported)	0.2	0.5	1.6	-0.2	-0.9	-0.1	-0.5	0.8	1.3	0.3
Respiratory disease	0.3	0.7	2.0	-0.7	-0.2	-0.3	-0.1	-1.4	-1.0	1.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.6	-0.7	-1.4	-1.3	-0.6	0.4	0.1	-1.6
Lung FEV1/FVC ratio	0.1	0.6	2.4	0.3	0.4	0.2	-0.4	-1.1	-1.6	-0.2
Lung FVC	0.4	1.9	3.9	1.5	0.9	1.0	1.1	1.8	2.0	0.9
Neuroticism	0.9	2.2	4.2	-2.0	-0.6	-2.0	-1.8	-1.3	-1.2	-0.7
Chronotype (morning person)	0.2	0.5	1.6	1.3	1.0	0.6	0.5	-0.2	-0.4	-0.2
Hair Pigment	0.0	1.0	2.4	0.9	0.7	1.0	0.7	1.6	1.1	-0.7
Tanning	0.1	0.7	1.3	0.5	-0.5	1.0	1.0	1.1	1.1	0.2
Hand grip strength (left)	0.4	1.0	4.1	1.3	0.6	2.0	1.0	0.2	0.1	-0.1
Number of treatments/medications taken	1.0	1.7	3.9	-1.6	-1.8	-2.0	-0.7	-0.3	-0.8	-1.2
Average weekly spirits intake	0.3	0.4	2.2	-1.5	-0.7	0.1	0.1	-0.3	-0.1	0.0
Sensitivity / hurt feelings	0.3	0.6	2.2	-1.5	-0.7	-1.2	-0.1	-0.1	-0.1	-0.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-1.0	0.3	-0.2	-0.7	-0.7	-0.6	-0.7
Hearing difficulty/problems: Yes	1.1	1.7	7.1	-0.7	-2.7	-1.2	0.9	0.9	0.8	-0.7
Relative age of first facial hair	0.9	1.9	8.6	0.4	2.9	0.7	-1.2	-0.0	-0.2	-1.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.7	0.8	0.7	-0.1	0.2	-0.0	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.1	0.6	0.7	-0.8	-0.0	0.2	-0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.6	-1.1	-0.1	0.5	0.5	0.8	1.1
Systolic blood pressure, automated reading	0.7	2.1	4.4	-1.4	0.4	-1.3	-1.6	-1.3	-1.4	-2.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.3	-0.1	-2.3	-1.4	-0.1	0.6	0.2	-0.7
Angina	1.4	1.9	4.0	-1.9	-1.1	-0.1	1.0	1.5	2.0	1.1
Medication for hormone replacement therapy	1.2	1.3	3.4	-0.1	-0.7	-0.7	-1.7	-1.8	-1.5	-0.4
Vitamin and mineral supplements	0.3	0.4	0.8	-0.3	0.7	0.4	0.5	0.9	0.7	-0.4
Supplements: Zinc	0.4	0.4	1.0	-0.9	-1.0	-0.7	-0.1	-0.7	-0.2	-0.0
Medication: Co-codamol	0.4	0.5	1.3	-1.0	0.1	-0.6	-0.4	0.1	-0.5	-1.1
Medication: Metformin	0.5	0.7	1.4	-0.7	-1.2	-0.4	0.9	1.0	1.1	-0.4
Diabetes (father)	2.2	2.7	6.0	0.5	0.1	-1.0	-2.1	-1.8	-2.1	-2.4
Diabetes (mother)	0.8	1.0	3.7	-0.1	1.3	0.5	-0.7	-0.4	-0.7	-1.9
Severe depression (siblings)	0.2	0.2	1.0	1.0	-0.3	0.1	0.4	-0.3	0.1	0.5
Pack years adult smoking proportion	1.6	2.4	4.8	-2.2	-1.7	-2.1	-1.0	-0.4	-0.9	-1.7
Impedance of leg (right)	0.3	1.4	3.5	-0.7	0.6	-1.0	-1.9	-0.8	-1.1	-1.5
Leg fat-free mass (left)	0.4	2.3	7.2	1.9	1.2	2.7	1.6	0.7	0.6	0.0
Trunk fat percentage	0.4	1.4	7.2	0.3	0.8	0.3	-0.7	-0.4	-1.1	-2.7
Hand grip strength (right)	0.8	2.2	5.8	2.0	1.1	2.4	1.4	0.9	0.8	0.8
Townsend deprivation index at recruitment	0.9	1.3	2.9	-1.6	-0.8	-1.7	-1.4	-0.8	-0.4	-0.5
Current tobacco smoking	0.2	0.4	1.3	-1.1	-0.9	-0.5	0.1	0.1	0.4	-0.6
Average weekly fortified wine intake	2.9	3.4	10.5	-1.8	-3.2	-2.3	1.2	0.6	0.5	1.8
Maternal smoking around birth	0.5	0.7	1.7	0.1	0.4	1.1	0.7	1.3	1.2	-0.1
Fed-up feelings	0.6	1.2	5.4	-2.3	-1.2	-1.0	-0.0	0.4	0.6	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.6	0.9	0.7	-0.1	-0.1	-0.3	-0.9
Relative age voice broke	0.6	0.9	2.3	-1.2	0.5	-0.7	-1.0	-0.3	-0.5	-1.5
Taking other prescription medications	0.8	1.2	2.9	-1.7	-1.2	-1.2	-0.7	-0.4	-0.6	-1.4
Age when periods started (menarche)	0.9	2.2	5.0	0.4	2.2	-0.4	-1.9	-0.6	-1.5	-2.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-0.7	-1.2	-1.0	-0.9	-0.0	0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	0.6	-0.0	-0.1	0.3	1.0	1.1	0.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.6	1.6	0.4	1.0	0.8	1.6	1.4	0.3
Qualifications: CSEs or equivalent	1.2	1.6	4.2	1.5	0.8	2.0	1.0	1.4	1.1	0.4
Serious illness, injury or assault to yourself	0.3	0.3	1.0	-0.6	-1.0	-0.3	0.3	0.7	0.0	-0.6
High blood pressure	0.6	1.7	7.3	-2.7	-0.7	-1.2	-0.4	-0.1	-0.4	-1.5
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.2	1.8	0.7	1.2	0.6	-0.1	0.2	1.8
Multivitamins +/- minerals	0.4	0.5	2.1	-0.1	-1.4	-0.6	-0.3	-0.6	-0.3	0.6
Stomach or abdominal pain in last month	3.1	3.9	8.3	-2.9	-2.9	-2.7	-0.8	-0.7	-0.7	-1.4
Supplements: Glucosamine	0.5	0.7	1.5	-0.3	-1.2	-1.0	-0.5	-0.1	-0.6	-1.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.5	-0.9	-0.9	-0.3	1.2	1.2	0.9	1.2
Medication: Atenolol	0.4	0.5	3.1	-1.8	0.3	-0.3	-0.0	-0.2	0.3	-0.4
Medication: Levothyroxine sodium	0.4	0.7	1.8	0.7	-0.2	0.4	0.3	1.3	1.4	0.6
Sitting height	1.7	12.0	29.9	4.3	3.0	5.5	3.6	2.0	2.2	2.1
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	-0.6	-0.0	-0.5	0.3	0.6	-0.0	-0.3
High blood pressure (mother)	1.0	1.4	2.4	-0.9	-0.7	-1.5	-1.5	-1.5	-1.2	-0.1
Body mass index (BMI)	0.1	0.4	2.2	0.1	0.2	0.3	0.5	0.2	-0.1	-1.5
Impedance of leg (left)	0.2	1.1	2.9	-0.3	0.8	-0.7	-1.7	-0.8	-1.1	-1.3
Leg predicted mass (left)	0.4	2.1	7.0	1.9	1.1	2.6	1.6	0.7	0.5	0.0
Trunk fat mass	0.3	1.3	5.9	0.7	1.0	0.9	0.0	-0.1	-0.8	-2.4
Waist circumference	0.2	0.6	1.8	-0.0	0.5	0.5	0.9	0.8	0.5	-1.4
Number of incorrect matches in round	0.7	1.1	2.2	-0.9	-1.3	-1.1	0.6	1.5	1.2	-0.2
Past tobacco smoking	0.5	0.9	1.9	1.1	0.5	0.1	-0.7	-1.1	-1.4	-1.2
Alcohol usually taken with meals	0.8	1.3	6.2	0.6	-1.2	-0.1	1.1	0.2	0.4	2.5
Nervous feelings	0.1	0.2	0.5	-0.4	-0.2	-0.3	0.4	0.4	0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.7	-1.6	-0.3	-1.4	-1.5	-0.9	-0.7	-0.8
Hearing difficulty/problems with background noise	0.7	1.1	2.8	0.2	-1.4	0.4	0.9	1.1	1.7	0.9
Hair/balding pattern: Pattern 2	2.1	2.7	6.6	2.5	2.2	2.6	0.7	0.2	0.3	0.6
Had menopause	0.7	0.9	2.1	-1.1	-1.4	-0.5	1.0	0.6	0.7	1.0
Had other major operations	0.4	0.5	2.0	-0.2	-0.2	0.0	0.2	0.9	1.4	0.7
Forced vital capacity (FVC)	1.6	6.3	13.9	3.7	2.6	3.6	1.7	1.8	1.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.4	0.1	-0.5	-0.5	0.3	0.6	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.5	-0.3	-0.3	-0.6	-0.2	-0.0	-0.5	-1.2
Qualifications: None of the above	0.8	1.8	5.9	-1.7	-0.6	-1.2	-0.3	1.3	0.7	-2.4
Financial difficulties in last 2 years	0.4	0.5	2.1	-0.5	-1.5	-0.9	-0.4	-0.0	0.1	0.1
Mouth/teeth dental problems	4.6	7.1	15.4	3.5	3.8	3.9	1.5	1.2	0.9	1.8
Heart attack	2.0	2.6	6.0	-0.2	1.3	1.6	1.4	2.4	2.4	0.7
Allergy	0.7	1.7	4.8	-1.3	-0.0	-1.5	-1.6	-0.4	-0.5	-2.2
Pain all over the body in last month	0.9	0.9	3.0	-0.1	0.6	0.4	1.2	1.1	1.7	0.4
Diabetes (self-reported)	0.3	0.5	1.1	-0.7	-1.0	-0.6	0.4	0.8	0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	1.0	1.1	0.7	0.2	-0.8	-0.5	0.7
Medication: Ramipril	0.8	1.1	3.1	-0.8	0.2	0.7	1.0	1.8	1.5	0.1
Medication: Simvastatin	0.6	0.9	3.6	-1.9	-1.0	-0.6	0.6	0.5	0.5	0.8
Fluid intelligence score	1.6	3.4	8.5	1.4	-0.8	1.1	2.3	1.4	2.1	2.9
Illnesses of siblings	0.3	0.4	1.2	1.1	0.2	0.3	0.3	-0.1	0.2	1.1
Neuroticism score	0.3	0.6	2.3	-1.5	-0.4	-1.2	-0.5	0.0	0.1	0.1
Weight	0.3	1.4	3.3	1.1	1.3	1.8	0.8	0.1	-0.3	-1.7
Impedance of arm (right)	0.1	0.5	1.5	0.5	0.0	-0.8	-1.2	-0.6	-1.0	-0.2
Arm fat percentage (right)	0.2	0.8	4.1	0.6	0.7	0.2	-0.0	0.0	-0.7	-2.0
Trunk fat-free mass	0.3	1.7	6.2	1.4	1.1	2.5	1.5	0.3	0.1	-0.2
Hip circumference	0.2	0.8	1.5	0.8	1.1	1.2	1.1	0.4	0.0	-0.8
Time employed in main current job	0.2	0.2	1.0	0.4	1.0	0.3	0.5	0.2	-0.2	0.2
Alcohol intake versus 10 years previously	1.4	2.1	5.2	-0.4	1.7	-0.5	-2.3	-1.5	-1.1	-1.6
Father’s age at death	0.1	0.1	0.3	0.2	-0.5	-0.5	0.0	0.4	0.4	0.3
Worrier / anxious feelings	0.6	1.1	3.5	-1.0	-0.8	-0.6	0.7	0.6	1.0	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.1	-0.4	-0.4	-1.0	-1.1	-1.0	-1.0	-0.5
Falls in the last year	0.3	0.4	1.0	-0.2	-1.0	-0.7	0.4	0.7	0.8	-0.0
Hair/balding pattern: Pattern 3	1.9	2.8	4.6	-2.0	-1.4	-2.1	-1.0	-1.3	-1.6	-2.1
Number of live births	0.7	1.0	3.0	-0.2	1.4	0.8	-1.3	-0.1	0.1	-1.7
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	14.4	3.8	2.7	3.4	1.3	1.5	1.3	0.9
Pulse rate	0.3	0.4	1.6	0.4	1.3	0.7	-0.4	0.5	0.5	-0.6
Happiness	1.9	2.3	6.7	1.4	-0.2	1.1	2.6	1.8	1.3	1.1
Noisy workplace	2.7	3.3	6.6	-2.6	-2.6	-1.9	1.1	1.6	0.7	-1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.7	-0.4	-1.4	-0.1	0.4	-0.6	0.0	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	-0.1	-0.6	-0.4	0.7	1.2	1.0	1.8
Mouth/teeth dental problems: Dentures	3.1	5.2	10.4	-3.2	-3.2	-3.2	-1.1	-1.4	-1.2	-1.3
Asthma	0.8	1.7	6.4	-0.2	-1.4	-0.2	1.8	0.1	0.3	2.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	0.6	1.1	1.2	0.9	0.3	-0.1	0.3
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.9	0.5	0.4	0.7	0.0	0.3	0.6
Depression (self-reported)	0.9	1.1	2.7	-0.7	-0.5	-0.9	-1.6	-1.3	-0.9	-0.8
Medication: Lansoprazole	0.7	0.8	3.7	0.1	1.9	1.3	-0.2	0.2	0.5	-0.3
Prospective memory result	0.6	0.7	1.6	-1.3	-0.1	-0.7	-1.0	-0.4	-0.8	-1.1
Lung cancer (father)	0.3	0.3	0.8	-0.6	0.2	0.1	-0.1	-0.9	-0.9	-0.6
Illnesses of mother	0.6	0.7	1.6	1.3	0.4	1.1	1.2	0.4	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	9.5	3.1	1.8	2.5	0.7	1.2	0.9	0.2
Pulse wave Arterial Stiffness index	2.2	2.6	6.1	0.6	-1.2	0.1	2.0	2.5	2.4	0.6
Impedance of arm (left)	0.1	0.6	2.1	0.4	0.4	-0.4	-1.4	-0.7	-1.0	-0.3
Arm fat mass (right)	0.2	0.8	3.2	1.1	0.7	0.8	0.5	0.3	-0.3	-1.8
Trunk predicted mass	0.3	1.7	6.4	1.4	1.1	2.5	1.5	0.3	0.1	-0.1
Standing height	0.4	3.7	12.7	2.3	2.5	3.6	0.6	-0.4	-0.7	-1.0
Length of working week for main job	0.6	0.6	1.6	0.5	-1.2	0.5	0.9	-0.1	-0.1	1.3
Exposure to tobacco smoke at home	1.4	1.5	4.3	-0.2	-0.8	-0.3	1.6	2.1	1.7	0.4
Breastfed as a baby	0.4	0.5	1.2	-0.7	0.2	-0.3	-0.0	-0.6	-1.1	-1.0
Tense / ‘highly strung’	0.6	0.9	3.0	-1.7	-0.5	-1.5	-0.9	0.1	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	3.7	-1.8	0.4	-0.8	-1.9	-1.9	-1.2	-0.5
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.2	-1.0	-0.3	-0.5	-0.8	-0.9	-0.2
Birth weight of first child	0.3	0.6	1.3	0.9	-1.1	-0.2	-0.0	-1.1	-0.8	0.1
Peak expiratory flow (PEF)	2.3	5.2	11.4	3.4	2.3	3.4	1.5	1.0	1.0	2.1
Pulse wave reflection index	1.8	2.2	4.1	0.4	-2.0	-0.4	1.7	1.6	1.8	1.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	-0.8	-1.0	-1.2	0.2	0.5	0.3	-1.2
Loud music exposure frequency	0.3	0.3	0.8	-0.0	-0.3	0.1	0.9	0.7	0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	1.1	-0.1	0.4	-0.4	-1.0	-0.6	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.1	-0.7	-0.1	0.2	0.8	0.9	-0.2
Blood clot in the leg (DVT)	0.5	0.6	2.4	0.2	1.1	1.5	-0.3	-0.4	-0.4	-0.1
Medication: Paracetamol	1.3	2.1	5.3	-1.9	-1.2	-1.6	-1.0	-0.1	-1.0	-2.3
Headache pain in last month	3.3	5.6	9.2	-1.9	-1.0	-2.7	-2.8	-3.0	-2.9	-1.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.4	-0.3	-1.2	-0.8	-0.9	-0.7	-0.3	-0.3
Glaucoma (self-reported)	0.2	0.3	0.6	0.2	-0.8	-0.5	-0.6	-0.2	-0.5	-0.6
Gout (self-reported)	0.5	0.7	1.2	-0.3	1.0	1.1	1.1	0.8	0.8	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.1	0.5	-0.3	0.3	0.3	1.3	1.4	0.7
Medication: Amlodipine	0.2	0.3	1.1	-0.0	-0.1	0.0	0.5	1.1	0.8	0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.7	-0.2	-1.7	-1.1	1.3	0.3	-0.0	0.8
Birth weight	0.2	0.5	1.4	0.6	-0.9	0.6	1.2	0.8	0.5	0.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	-1.4	0.1	-0.6	-0.4	-0.6	-0.2	-0.9
High blood pressure (siblings)	0.4	0.6	2.7	-1.6	-0.6	-0.6	-0.4	-0.7	-0.3	-0.2
Forced vital capacity (FVC), Best measure	1.0	3.5	9.6	3.1	1.4	2.7	1.1	1.4	1.5	0.6
Body fat percentage	0.4	1.4	7.4	0.2	0.9	0.1	-0.7	-0.4	-1.1	-2.7
Leg fat percentage (right)	0.3	1.2	7.0	-0.4	0.8	-0.4	-0.3	0.1	-0.6	-2.6
Arm fat-free mass (right)	0.4	2.0	7.7	1.4	1.6	2.8	1.1	0.3	0.3	-0.5
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.4	-0.2	-0.8	-0.6	-0.4	-0.4	-0.5
Comparative body size at age 10	0.1	0.2	0.6	-0.7	0.1	0.5	0.8	-0.1	0.0	0.2
Number of full brothers	0.3	0.3	1.8	-1.4	-0.0	-0.5	0.3	0.1	0.4	0.2
Worry too long after embarrassment	0.1	0.2	1.3	0.1	0.1	-0.6	0.1	-0.2	-0.0	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.5	-1.1	-1.6	-1.0	-0.7	-1.0	-0.4	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.2	-0.7	-0.7	-0.2	-0.5	-0.8	-0.2
Number of children fathered	0.3	0.4	1.3	-0.2	0.2	0.5	0.7	1.1	0.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.8	0.8	0.4	-0.2	-0.5	-0.5	-0.2
Age at first live birth	0.4	0.7	1.2	1.0	0.7	0.8	0.8	-0.7	-1.1	0.7
Pulse wave peak to peak time	2.5	2.9	6.7	-0.5	1.4	0.1	-2.1	-2.6	-2.6	-0.9
Health satisfaction	0.4	0.6	2.2	-1.0	-0.6	-0.4	-0.1	-0.1	-0.4	-1.5
Shortness of breath walking on level ground	1.4	1.6	3.6	-1.4	-1.4	-1.6	-0.7	-0.3	-0.8	-1.9
Qualifications: College or University degree	0.6	2.0	11.2	0.9	-0.1	0.6	1.1	-0.3	0.2	3.3
Eye problems/disorders: None of the above	3.1	3.6	8.9	1.0	1.1	1.5	1.9	1.6	2.4	3.0
Mouth/teeth dental problems: Loose teeth	5.7	6.7	9.4	-3.1	-2.1	-2.9	-2.6	-2.1	-2.1	-3.0
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.3	-0.6	-0.0	-0.3	-0.1	-0.4	-0.4
Medication for pain relief, constipation, heartburn	1.1	1.8	5.5	2.2	0.2	1.0	0.7	0.3	1.0	2.3
Neck or shoulder pain in last month	0.5	0.7	2.5	-1.6	-0.5	-1.0	-0.5	-0.5	-0.5	-0.6
Medication: Blood pressure	0.2	0.3	0.7	-0.1	0.8	0.2	0.8	0.7	0.3	0.1
Angina (self-reported)	1.4	1.8	4.1	-1.8	-0.9	0.1	0.9	1.5	2.0	1.2
Migraine (self-reported)	0.9	1.1	3.7	0.8	1.9	0.5	-0.6	-1.2	-1.0	0.1
Medication: Ibuprofen	1.2	1.4	2.9	1.1	1.1	1.7	1.4	1.1	0.9	0.8
Medication: Allopurinol	0.2	0.2	0.7	-0.6	-0.6	-0.1	0.3	0.1	0.2	0.8
Medication: Omeprazole	0.6	0.8	2.0	-1.4	-0.7	-1.2	-0.5	0.3	0.1	-1.1
Medication: Seretide 50 evohaler	0.3	0.3	0.5	-0.7	-0.7	-0.7	-0.4	-0.6	-0.7	-0.0
Mean time to correctly identify matches	0.3	0.5	1.3	-0.6	-1.0	-1.1	0.3	-0.6	-0.2	0.6
Heart disease (mother)	1.2	1.5	2.9	-1.7	0.1	-1.1	-1.7	-1.4	-0.9	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.0	0.4	1.0	-0.4	-0.3	-0.4	-0.7	-0.3
Whole body fat mass	0.3	1.3	5.9	0.8	1.1	0.9	0.0	-0.2	-0.8	-2.4
Leg fat mass (right)	0.2	0.9	4.0	0.5	1.0	0.8	0.6	0.5	-0.1	-2.0
Arm predicted mass (right)	0.4	1.9	7.1	1.5	1.5	2.7	1.1	0.2	0.2	-0.5
Pulse rate, automated reading	0.2	0.7	1.8	-0.8	0.8	-0.7	-1.3	-0.5	-0.0	-0.8
Alcohol intake frequency.	0.4	0.8	2.3	1.0	1.5	0.1	-0.6	-0.5	-0.9	-1.1
Comparative height size at age 10	0.2	0.9	2.4	1.5	0.1	1.6	0.2	-0.1	-0.8	-1.0
Number of full sisters	0.6	0.7	1.4	-1.2	-1.1	-0.2	0.3	1.0	1.0	-0.7
Suffer from ‘nerves’	0.6	0.9	2.0	-0.8	-0.8	-1.4	-1.3	-0.3	-0.5	-0.9
Overall health rating	0.5	1.1	2.5	-1.4	-1.3	-1.0	0.2	0.4	-0.1	-1.6
Chest pain or discomfort	0.1	0.1	0.4	-0.4	0.1	-0.0	-0.2	0.0	-0.1	-0.6
Had major operations	0.3	0.3	1.4	-0.4	-1.2	-0.8	0.1	0.3	0.0	0.0
Age at last live birth	0.5	0.8	1.6	0.6	1.2	0.6	-0.5	-1.0	-1.3	-0.7
Family relationship satisfaction	0.3	0.4	0.9	-0.0	-1.0	-0.6	0.4	0.9	0.5	-0.3
Leg pain on walking	1.1	1.3	2.9	-1.0	-1.7	-1.6	0.0	1.1	0.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.5	0.7	1.6	1.0	-0.5	-0.0	-0.3	-1.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.3	-1.1	0.1	0.5	1.2	1.5	0.6	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	0.9	0.6	0.6	0.5	0.5	0.6	-0.1
Medication: Aspirin	0.6	0.8	3.7	-1.9	-0.1	-0.4	0.3	0.6	0.7	-0.8
Supplements: Vitamin C	0.7	0.8	2.4	-0.9	-1.6	-1.1	-0.4	-0.7	-0.6	-0.3
Knee pain experienced in last month	0.5	0.8	3.2	-0.3	-0.1	-0.8	-1.1	-0.6	-0.5	-1.8
Hypertension (Self-reported)	0.5	1.5	6.2	-2.5	-0.5	-1.1	-0.5	-0.0	-0.2	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.2	0.2	0.4	0.8	0.4	0.6	-0.0
Illnesses of father: Heart disease	0.3	0.4	0.9	0.2	-0.8	-0.2	-0.9	-0.7	-0.4	-0.9
Illnesses of siblings: Diabetes	0.3	0.3	0.8	0.6	0.6	0.9	-0.3	0.6	0.6	0.3
Smoking status: Previous	0.5	0.8	2.0	-0.4	0.3	0.6	0.8	1.0	1.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	9.2	2.3	1.9	3.0	1.8	0.8	0.9	1.2
Whole body fat-free mass	0.4	2.1	7.2	1.8	1.2	2.7	1.5	0.4	0.3	-0.0
Leg fat-free mass (right)	0.5	2.8	8.5	2.3	1.3	2.9	1.8	0.7	0.7	0.3
Arm fat percentage (left)	0.2	0.7	3.5	0.6	0.7	0.3	-0.1	-0.0	-0.7	-1.9
Average weekly red wine intake	3.4	5.0	10.4	1.6	1.5	3.0	2.1	1.5	2.0	3.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.3	0.9	0.2	0.3	0.3	1.5	0.7	-0.4
Mood swings	0.1	0.2	0.7	-0.9	0.1	-0.5	-0.3	0.0	0.3	-0.0
Loneliness, isolation	1.7	2.3	5.9	-2.4	-2.1	-1.5	0.9	0.5	1.0	1.2
Long-standing illness, disability or infirmity	0.6	0.9	1.9	-1.1	-1.3	-1.4	-0.4	-0.2	-0.4	-1.0
Ever had bowel cancer screening	0.4	0.5	2.2	-0.2	0.1	-0.7	-0.7	0.3	-0.6	-1.5
Diabetes diagnosed by doctor	0.4	0.7	2.0	-0.9	-1.4	-0.7	0.3	0.7	0.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.6	0.1	1.2	0.6	-0.6	-0.1	0.5	-0.1
Friendships satisfaction	0.8	1.0	2.4	0.3	0.1	0.8	1.6	1.5	1.1	0.8
Qualifications: nursing, teaching	0.8	1.3	2.7	0.3	1.3	0.9	-0.8	-1.6	-0.6	1.6
Commuting to job workplace: Walk	0.4	0.4	1.1	1.0	-0.3	-0.5	-0.7	0.2	0.0	-1.0
Eye problems/disorders: Cataract	4.4	5.1	12.8	-1.2	0.5	-0.5	-2.7	-2.4	-2.8	-3.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	-1.1	-0.6	-1.2	-0.2	-0.3	-0.1	-0.2
Medication for cholesterol	0.8	1.2	2.0	1.1	1.0	1.0	1.4	1.0	0.8	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	8.9	0.3	0.6	-0.1	-0.9	-1.2	-1.8	-3.0
Back pain experienced in last month	0.5	0.8	2.8	-1.7	-0.1	-0.1	0.2	1.0	1.1	-0.4
Mineral and other dietary supplements	0.4	0.5	1.6	0.7	1.3	1.1	0.3	-0.0	0.3	0.3
Breast cancer (self-reported)	1.2	1.4	2.9	-1.7	0.6	-1.0	-1.7	-1.2	-1.0	-0.8
Asthma (self-reported)	0.7	1.3	4.7	-0.3	-1.4	-0.3	1.5	0.0	0.1	2.2
Osteoporosis (self-reported)	0.7	0.8	1.7	0.0	-1.2	-1.0	1.3	0.1	-0.0	1.2
Osteoarthritis (self-reported)	0.4	0.5	1.6	-1.0	-0.7	-1.3	-0.6	-0.4	0.2	-0.4
Medication: Aspirin	0.7	0.9	4.7	-2.2	-0.3	-0.3	0.4	0.8	0.7	-0.7
Medication: Gliclazide	0.4	0.5	1.6	-0.7	-1.3	-0.6	0.1	0.2	0.3	-0.8
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.2	-0.5	-0.4	-0.6	-0.3	0.0	0.1
Smoking status: Current	0.3	0.5	1.8	-1.3	-0.8	-0.6	-0.1	-0.0	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.2	-0.4	-0.1	0.4	0.6	0.8	0.4
Whole body water mass	0.4	2.0	7.0	1.7	1.2	2.6	1.6	0.4	0.3	-0.1
Leg predicted mass (right)	0.5	2.7	8.4	2.3	1.3	2.9	1.7	0.7	0.6	0.3
Arm fat mass (left)	0.2	0.9	3.4	1.0	0.8	0.9	0.3	-0.0	-0.5	-1.9
Number of self-reported non-cancer illnesses	0.7	1.2	3.7	-1.8	-1.9	-1.2	0.2	0.1	0.2	0.4
Average weekly champagne plus white wine intake	2.3	3.1	7.0	-0.4	-0.8	-1.5	-1.6	-2.5	-2.7	-1.7
Miserableness	0.6	1.1	3.4	-1.8	-0.7	-1.1	-0.7	0.0	-0.3	-1.4
Guilty feelings	0.3	0.5	0.9	-0.9	0.4	-0.8	-0.7	-0.8	-0.8	0.3
Wears glasses or contact lenses	0.7	0.8	2.7	-1.7	-1.1	-1.1	-0.0	0.1	0.4	0.5
Ever taken oral contraceptive pill	0.5	0.5	2.1	-0.8	0.6	0.5	-1.5	-0.5	0.0	-0.2
Hearing aid user	0.6	0.7	2.3	-0.7	-1.5	-1.3	0.1	-0.1	-0.1	-0.7
Mother’s age at death	0.3	0.4	0.7	-0.7	-0.7	-0.8	0.1	-0.5	-0.7	-0.3
Financial situation satisfaction	0.1	0.1	0.4	-0.4	-0.4	-0.0	-0.1	0.0	-0.2	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.6	2.9	-1.7	-0.7	-0.8	0.1	0.5	-0.3	-0.5
Commuting to job workplace: Public transport	1.9	2.2	5.5	2.3	0.9	1.4	1.1	0.8	1.3	1.9
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	0.7	-0.4	0.1	0.3	0.6	0.2	-0.1
Medication: Blood pressure	0.5	0.9	3.3	-1.8	-1.0	-0.9	-0.5	0.3	0.5	-0.7
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.9	-1.3	0.8	0.0	-1.2	-1.4	-1.5	-2.0
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	0.1	-0.4	0.1	0.5	0.8	0.7	0.8
High cholesterol (Self-reported)	1.6	2.9	6.0	-0.0	-0.9	0.3	2.5	2.0	2.2	2.0
Medication: Bendroflumethiazide	0.3	0.4	1.4	-1.2	0.1	-0.4	-0.4	0.0	-0.1	-0.9
Medication: Paracetamol	1.2	1.9	4.0	-1.5	-1.6	-1.6	-0.9	-0.3	-0.9	-2.0
Medication: Lisinopril	0.1	0.2	0.6	-0.6	-0.8	-0.2	0.4	0.1	0.2	-0.3
Medication: Atorvastatin	0.1	0.1	0.2	-0.2	0.5	0.3	0.1	0.5	0.4	-0.1
Illnesses of father: High blood pressure	0.5	0.6	2.3	1.0	1.5	0.9	-0.1	-0.2	-0.4	-0.1
Alcohol drinker status: Never	1.2	1.5	5.5	0.3	0.2	0.5	1.5	1.0	0.9	2.4
Ever smoked	0.4	0.6	1.2	-1.0	-0.6	-0.5	0.6	0.9	1.1	0.7
Basal metabolic rate	0.4	2.0	6.8	1.8	1.3	2.6	1.4	0.4	0.2	-0.4
Leg fat percentage (left)	0.3	1.1	6.6	0.0	0.9	-0.2	-0.2	0.2	-0.5	-2.6
Arm fat-free mass (left)	0.3	1.6	5.3	1.5	1.1	2.3	1.2	0.4	0.3	-0.5
Number of operations (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.2	-0.5	0.3	0.5	0.3
Average weekly beer plus cider intake	0.4	0.6	3.2	-0.6	0.6	-0.3	-0.5	0.1	0.1	-1.8
Irritability	3.1	5.2	9.7	-2.8	-0.3	-2.0	-2.7	-1.6	-2.3	-3.1
Risk taking	0.6	0.9	4.2	2.1	0.8	1.1	-0.0	0.4	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	-0.1	-0.7	-0.6	0.7	1.1	0.8	-0.5
Fractured/broken bones in last 5 years	0.3	0.3	1.3	0.3	-0.3	-0.1	0.8	0.2	0.5	1.1
Age started oral contraceptive pill	0.5	0.6	1.8	-1.3	-0.9	-1.3	-0.2	-0.2	0.0	0.3
Diastolic blood pressure, automated reading	0.6	1.8	5.7	0.9	2.4	0.7	-1.0	-0.5	-0.5	-2.1
Ever depressed for a whole week	0.5	0.7	2.2	1.2	1.5	0.3	-0.4	0.2	0.1	-0.8
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.2	-0.4	-0.8	-0.8	-0.4	-0.1	-0.5
Commuting to job workplace: Cycle	1.5	1.8	6.8	0.7	-0.3	0.1	1.7	0.9	1.1	2.6
Myopia	0.5	0.8	1.8	1.4	0.2	0.6	0.9	1.1	1.0	0.3
Vascular/heart problems diagnosed by doctor	0.5	1.4	6.2	2.5	0.6	0.6	-0.5	-1.0	-0.7	0.8
Cholesterol lowering medication	0.6	0.9	1.5	-0.6	-1.1	0.2	1.0	1.2	1.2	0.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.9	-2.2	-0.6	-1.4	-0.8	-0.3	0.1	-0.8
Pain experienced in last month	1.9	3.2	5.2	2.3	0.1	2.0	1.9	1.6	1.5	2.2
Supplements: Calcium	2.6	2.8	6.6	-1.8	-2.6	-2.1	-1.1	-1.0	-1.4	-1.1
Basal cell carcinoma (self-reported)	2.3	2.8	7.2	1.1	-0.1	0.7	2.0	2.7	2.4	0.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.0	-0.2	1.3	1.5	1.2	2.2	2.2	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.2	-0.1	1.0	1.5	-0.2	-0.1	-0.2	-0.1
Heart disease (siblings)	1.4	1.7	4.0	-2.0	-0.9	-1.6	-1.2	-0.7	-0.8	-1.5
Alcohol drinker status: Previous	0.7	0.8	1.7	0.2	-0.7	-1.2	-0.5	-1.2	-1.3	0.2
Pack years of smoking	2.2	3.3	7.6	-2.8	-2.1	-2.5	-1.1	-0.3	-0.9	-1.7
Impedance of whole body	0.2	0.9	3.0	0.1	0.8	-0.5	-1.7	-0.9	-1.1	-0.8
Leg fat mass (left)	0.2	0.9	3.6	0.6	0.9	0.8	0.7	0.6	-0.0	-1.9
Arm predicted mass (left)	0.3	1.5	5.0	1.5	1.3	2.2	1.0	0.0	-0.0	-0.7