Best TWAS P=1.62e-12 · Best GWAS P=2.62e-12 conditioned to 0.19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | THUMPD1 | 0.05 | 0.01 | bslmm | 403 | 0.02 | 3.2e-03 | -6.59 | 5.5 | 2.8e-08 | -0.73 | 0.02 | 0.87 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC004381.6 | 0.09 | 0.04 | enet | 35 | 0.02 | 1.6e-02 | -4.75 | -5.9 | 3.3e-09 | 0.48 | 0.20 | 0.43 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | ERI2 | 0.06 | 0.02 | enet | 3 | 0.01 | 3.3e-02 | -6.76 | -6.6 | 3.4e-11 | 0.87 | 0.03 | 0.91 | FALSE |
| 4 | GTEx | Brain Cerebellum | AC004381.6 | 0.23 | 0.09 | enet | 18 | 0.12 | 1.9e-04 | -4.75 | -5.2 | 2.6e-07 | 0.50 | 0.23 | 0.22 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | THUMPD1 | 0.13 | 0.16 | enet | 16 | 0.16 | 4.2e-12 | -6.77 | -7.1 | 1.6e-12 | 0.92 | 0.02 | 0.98 | TRUE |
| 6 | GTEx | Testis | AC004381.6 | 0.18 | 0.10 | lasso | 7 | 0.08 | 1.8e-04 | -6.80 | -6.9 | 6.4e-12 | 0.93 | 0.02 | 0.95 | FALSE |
| 7 | METSIM | Adipose | ACSM1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 9.5e-09 | -6.72 | -6.4 | 2.0e-10 | 0.87 | 0.03 | 0.97 | FALSE |
| 8 | METSIM | Adipose | THUMPD1 | 0.03 | 0.00 | blup | 382 | 0.02 | 4.9e-04 | -0.26 | -5.3 | 1.4e-07 | 0.68 | 0.06 | 0.89 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | THUMPD1 | 0.08 | 0.12 | enet | 24 | 0.12 | 3.0e-15 | -6.72 | 6.6 | 4.7e-11 | -0.93 | 0.02 | 0.98 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | ACSM1 | 0.07 | 0.06 | lasso | 8 | 0.06 | 1.0e-07 | -4.90 | -5.7 | 1.5e-08 | 0.58 | 0.90 | 0.10 | FALSE |
| 11 | YFS | Blood | THUMPD1 | 0.03 | 0.03 | lasso | 14 | 0.03 | 5.4e-10 | -4.74 | -6.0 | 1.6e-09 | 0.66 | 0.58 | 0.42 | FALSE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | THUMPD1 | 0.04 | 0.04 | blup | 30 | 0.03 | 2.3e-03 | -6.78 | -7.0 | 1.7e-12 | 0.92 | 0.01 | 0.86 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ACSM3 | 0.06 | 0.06 | lasso | 13 | 0.05 | 2.8e-06 | -6.77 | 6.8 | 1.3e-11 | -0.94 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | THUMPD1 | 0.07 | 0.06 | blup | 30 | 0.06 | 5.6e-07 | -6.77 | 5.7 | 1.2e-08 | -0.86 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ACSM1 | 0.10 | 0.05 | blup | 54 | 0.07 | 7.8e-05 | -6.77 | -5.6 | 1.7e-08 | 0.74 | 0.00 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | ACSM3 | 0.06 | 0.04 | blup | 43 | 0.03 | 5.9e-04 | -6.81 | 6.8 | 1.2e-11 | -0.90 | 0.01 | 0.96 | FALSE |