Best TWAS P=4.11e-22 · Best GWAS P=4.24e-24 conditioned to 0.00153
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AKTIP | 0.12 | 0.09 | enet | 10 | 0.08 | 1.9e-10 | 6.6 | -5.7 | 1.1e-08 | -0.63 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RBL2 | 0.22 | 0.24 | enet | 15 | 0.26 | 1.8e-31 | 6.6 | -8.4 | 2.9e-17 | -0.86 | 0.78 | 0.22 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RBL2 | 0.34 | 0.28 | enet | 18 | 0.30 | 1.0e-24 | 6.7 | -7.1 | 1.4e-12 | -0.74 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | RBL2 | 0.30 | 0.27 | lasso | 2 | 0.27 | 4.3e-14 | 6.7 | -6.7 | 3.0e-11 | -0.69 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Adrenal Gland | RBL2 | 0.35 | 0.27 | enet | 22 | 0.25 | 2.3e-09 | 6.7 | -6.2 | 5.4e-10 | -0.67 | 0.94 | 0.06 | FALSE |
| 6 | GTEx | Artery Aorta | RBL2 | 0.27 | 0.21 | enet | 14 | 0.19 | 1.5e-10 | 6.6 | -6.7 | 2.8e-11 | -0.69 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Coronary | RBL2 | 0.36 | 0.33 | enet | 14 | 0.27 | 1.4e-09 | 6.6 | -6.4 | 1.6e-10 | -0.68 | 0.98 | 0.02 | FALSE |
| 8 | GTEx | Artery Tibial | RBL2 | 0.16 | 0.17 | enet | 11 | 0.20 | 2.1e-15 | 6.6 | -8.2 | 1.6e-16 | -0.83 | 0.51 | 0.49 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | RBL2 | 0.55 | 0.55 | enet | 20 | 0.46 | 2.1e-13 | 6.7 | -7.0 | 3.5e-12 | -0.70 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Brain Cerebellum | RBL2 | 0.66 | 0.72 | enet | 16 | 0.70 | 5.7e-28 | 6.6 | -6.8 | 7.6e-12 | -0.71 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | 5.8 | -7.7 | 1.6e-14 | -0.80 | 0.28 | 0.72 | FALSE |
| 12 | GTEx | Breast Mammary Tissue | RBL2 | 0.36 | 0.35 | lasso | 3 | 0.36 | 3.0e-19 | 6.6 | -6.5 | 9.1e-11 | -0.68 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Breast Mammary Tissue (Male) | RBL2 | 0.40 | 0.29 | lasso | 2 | 0.25 | 1.4e-06 | 6.6 | -6.6 | 5.4e-11 | -0.68 | 0.47 | 0.24 | FALSE |
| 14 | GTEx | Breast Mammary Tissue (Female) | RBL2 | 0.47 | 0.27 | lasso | 7 | 0.20 | 1.1e-06 | 5.8 | -6.0 | 1.6e-09 | -0.67 | 0.78 | 0.19 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | RBL2 | 0.13 | 0.05 | enet | 9 | 0.02 | 8.9e-03 | 6.6 | -5.1 | 3.1e-07 | -0.64 | 0.35 | 0.38 | FALSE |
| 16 | GTEx | Colon Sigmoid | RBL2 | 0.38 | 0.37 | lasso | 12 | 0.29 | 8.4e-11 | 6.7 | -7.6 | 2.3e-14 | -0.79 | 0.59 | 0.41 | FALSE |
| 17 | GTEx | Colon Transverse | RBL2 | 0.59 | 0.44 | enet | 13 | 0.52 | 4.4e-28 | 6.7 | -7.2 | 5.1e-13 | -0.75 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Esophagus Gastroesophageal Junction | RBL2 | 0.38 | 0.40 | enet | 17 | 0.38 | 1.1e-14 | 6.6 | -6.4 | 1.5e-10 | -0.69 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Esophagus Mucosa | RBL2 | 0.36 | 0.36 | enet | 37 | 0.37 | 2.9e-26 | 6.7 | -7.2 | 7.3e-13 | -0.78 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Esophagus Muscularis | RBL2 | 0.36 | 0.38 | enet | 10 | 0.41 | 6.8e-27 | 6.6 | -6.4 | 1.2e-10 | -0.68 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Heart Atrial Appendage | RBL2 | 0.28 | 0.14 | enet | 25 | 0.23 | 8.6e-11 | 6.6 | -6.5 | 7.0e-11 | -0.76 | 0.11 | 0.89 | FALSE |
| 22 | GTEx | Heart Left Ventricle | RBL2 | 0.12 | 0.11 | enet | 12 | 0.08 | 3.3e-05 | 6.6 | -6.2 | 5.3e-10 | -0.62 | 0.71 | 0.25 | FALSE |
| 23 | GTEx | Lung | RBL2 | 0.29 | 0.37 | enet | 16 | 0.35 | 9.1e-28 | 6.7 | -7.1 | 1.2e-12 | -0.73 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | 9.5 | -8.6 | 5.6e-18 | -0.86 | 0.01 | 0.96 | FALSE |
| 25 | GTEx | Nerve Tibial | RBL2 | 0.46 | 0.52 | enet | 19 | 0.53 | 1.6e-43 | 6.6 | -7.2 | 8.4e-13 | -0.74 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Ovary | RBL2 | 0.41 | 0.26 | enet | 29 | 0.18 | 3.2e-05 | 6.6 | -6.7 | 1.7e-11 | -0.72 | 0.09 | 0.88 | FALSE |
| 27 | GTEx | Pancreas | RBL2 | 0.36 | 0.36 | enet | 26 | 0.36 | 5.9e-16 | 6.6 | -7.4 | 1.1e-13 | -0.78 | 0.86 | 0.14 | FALSE |
| 28 | GTEx | Pituitary | RBL2 | 0.36 | 0.39 | lasso | 6 | 0.40 | 4.5e-11 | 6.6 | 6.7 | 2.1e-11 | 0.68 | 0.74 | 0.25 | FALSE |
| 29 | GTEx | Prostate | RBL2 | 0.55 | 0.45 | lasso | 4 | 0.45 | 1.0e-12 | 6.6 | -6.7 | 2.6e-11 | -0.69 | 0.97 | 0.03 | FALSE |
| 30 | GTEx | Skin Not Sun Exposed Suprapubic | RBL2 | 0.35 | 0.33 | enet | 16 | 0.34 | 2.6e-19 | 6.6 | -7.0 | 2.2e-12 | -0.74 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Skin Sun Exposed Lower leg | RBL2 | 0.35 | 0.39 | enet | 25 | 0.37 | 2.9e-32 | 6.6 | -7.2 | 5.6e-13 | -0.72 | 1.00 | 0.00 | FALSE |
| 32 | GTEx | Spleen | RBL2 | 0.59 | 0.47 | enet | 51 | 0.46 | 3.2e-13 | 6.6 | -7.0 | 2.4e-12 | -0.65 | 0.37 | 0.63 | FALSE |
| 33 | GTEx | Stomach | RBL2 | 0.33 | 0.26 | enet | 20 | 0.26 | 8.7e-13 | 6.7 | -6.6 | 4.7e-11 | -0.62 | 1.00 | 0.00 | FALSE |
| 34 | GTEx | Thyroid | RBL2 | 0.34 | 0.47 | lasso | 4 | 0.45 | 3.6e-38 | 6.7 | -6.8 | 1.4e-11 | -0.70 | 1.00 | 0.00 | FALSE |
| 35 | GTEx | Vagina | RBL2 | 0.41 | 0.37 | enet | 13 | 0.34 | 1.6e-08 | 7.1 | -7.4 | 1.5e-13 | -0.75 | 0.34 | 0.62 | FALSE |
| 36 | NTR | Blood | RBL2 | 0.09 | 0.11 | bslmm | 419 | 0.11 | 1.1e-33 | 6.7 | -6.6 | 3.9e-11 | -0.68 | 1.00 | 0.00 | FALSE |
| 37 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | 10.1 | 9.1 | 6.7e-20 | 0.93 | 0.00 | 1.00 | FALSE |
| 38 | YFS | Blood | RBL2 | 0.18 | 0.26 | bslmm | 381 | 0.27 | 6.9e-90 | 6.6 | -6.3 | 2.8e-10 | -0.63 | 1.00 | 0.00 | FALSE |
| 39 | The Cancer Genome Atlas | Esophageal Carcinoma | RBL2 | 0.08 | 0.04 | lasso | 3 | 0.03 | 4.4e-02 | 10.1 | 8.6 | 6.7e-18 | 0.85 | 0.01 | 0.82 | FALSE |
| 40 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AKTIP | 0.04 | 0.03 | blup | 42 | 0.05 | 1.9e-06 | 6.6 | -6.0 | 2.7e-09 | -0.67 | 0.98 | 0.01 | FALSE |
| 41 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBL2 | 0.03 | 0.06 | enet | 5 | 0.05 | 8.2e-07 | 5.8 | -7.4 | 1.4e-13 | -0.78 | 0.82 | 0.18 | FALSE |
| 42 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | 9.6 | -9.7 | 4.1e-22 | -0.91 | 0.01 | 0.78 | TRUE |