Best TWAS P=2.98e-10 · Best GWAS P=2.53e-08 conditioned to 0.197
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM106A | 0.05 | 0.01 | bslmm | 278 | 0.02 | 8.6e-04 | 2.9 | 6.1 | 8.4e-10 | 0.48 | 0.08 | 0.25 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ALKBH5 | 0.16 | 0.05 | lasso | 7 | 0.10 | 9.2e-08 | -4.3 | -5.2 | 1.6e-07 | -0.69 | 0.52 | 0.43 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-258F1.1 | 0.18 | 0.12 | lasso | 3 | 0.15 | 1.7e-11 | -4.3 | -5.2 | 2.7e-07 | -0.70 | 0.49 | 0.47 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LLGL1 | 0.19 | 0.06 | lasso | 5 | 0.06 | 1.1e-04 | 5.1 | 5.2 | 1.6e-07 | 0.95 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Small Intestine Terminal Ileum | CTD-2303H24.2 | 0.38 | 0.28 | lasso | 9 | 0.26 | 1.7e-06 | 4.8 | 5.2 | 2.6e-07 | 0.91 | 0.02 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ALKBH5 | 0.06 | 0.02 | blup | 63 | 0.02 | 7.2e-06 | 4.4 | -6.1 | 1.3e-09 | -0.63 | 0.08 | 0.65 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ALKBH5 | 0.09 | 0.02 | lasso | 3 | 0.03 | 1.2e-04 | 4.5 | -5.6 | 1.9e-08 | -0.79 | 0.03 | 0.89 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ALKBH5 | 0.22 | 0.10 | blup | 66 | 0.12 | 1.4e-05 | 5.1 | -6.3 | 3.0e-10 | -0.75 | 0.02 | 0.92 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ALKBH5 | 0.19 | 0.02 | blup | 63 | 0.04 | 3.4e-05 | 4.8 | -5.1 | 3.0e-07 | -0.77 | 0.02 | 0.95 | FALSE |