Best TWAS P=2.51e-22 · Best GWAS P=2.45e-21 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PIP4K2B | 0.15 | 0.07 | lasso | 5 | 0.07 | 2.2e-06 | -9.5 | -9.1 | 6.0e-20 | 0.95 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | PSMB3 | 0.23 | 0.17 | enet | 26 | 0.22 | 2.1e-12 | -9.5 | -7.5 | 8.6e-14 | 0.84 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | PIP4K2B | 0.31 | 0.03 | enet | 42 | 0.10 | 2.6e-06 | -1.2 | -5.9 | 3.4e-09 | 0.46 | 0.04 | 0.94 | FALSE |
| 4 | GTEx | Artery Tibial | PSMB3 | 0.10 | 0.02 | enet | 12 | 0.03 | 1.2e-03 | -9.5 | -7.2 | 5.0e-13 | 0.73 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | PIP4K2B | 0.37 | 0.16 | enet | 49 | 0.22 | 2.1e-17 | -9.5 | -8.8 | 1.1e-18 | 0.76 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Pituitary | CWC25 | 0.30 | 0.00 | enet | 18 | 0.07 | 7.4e-03 | -4.9 | -5.2 | 2.3e-07 | 0.46 | 0.08 | 0.24 | FALSE |
| 7 | GTEx | Testis | PSMB3 | 0.30 | 0.24 | lasso | 4 | 0.21 | 8.9e-10 | -9.5 | -9.7 | 2.5e-22 | 1.00 | 0.00 | 1.00 | TRUE |
| 8 | METSIM | Adipose | PIP4K2B | 0.06 | 0.01 | blup | 360 | 0.02 | 7.0e-04 | -2.3 | -5.5 | 4.1e-08 | 0.50 | 0.01 | 0.98 | FALSE |
| 9 | METSIM | Adipose | PSMB3 | 0.04 | 0.02 | lasso | 5 | 0.01 | 2.3e-03 | -6.9 | -6.7 | 2.2e-11 | 0.51 | 0.14 | 0.31 | FALSE |
| 10 | NTR | Blood | PIP4K2B | 0.02 | 0.01 | lasso | 3 | 0.01 | 6.4e-04 | -9.5 | 9.2 | 4.6e-20 | -0.97 | 0.00 | 1.00 | FALSE |
| 11 | YFS | Blood | PSMB3 | 0.14 | 0.11 | enet | 31 | 0.16 | 7.2e-49 | -9.0 | -5.6 | 2.1e-08 | 0.81 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PIP4K2B | 0.04 | 0.01 | blup | 56 | 0.03 | 6.3e-04 | -9.0 | -6.8 | 8.0e-12 | 0.83 | 0.00 | 0.92 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PIP4K2B | 0.07 | 0.01 | enet | 12 | 0.02 | 4.3e-03 | -4.9 | -6.4 | 1.8e-10 | 0.52 | 0.03 | 0.28 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PSMB3 | 0.14 | 0.05 | blup | 42 | 0.05 | 8.9e-07 | -9.0 | -6.8 | 1.4e-11 | 0.70 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSMB3 | 0.12 | 0.02 | enet | 14 | 0.05 | 1.3e-03 | -6.9 | -7.1 | 1.3e-12 | 0.63 | 0.01 | 0.74 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIP4K2B | 0.05 | 0.04 | blup | 56 | 0.05 | 5.3e-06 | -6.9 | -9.1 | 6.1e-20 | 0.86 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB3 | 0.11 | 0.07 | blup | 42 | 0.07 | 9.4e-08 | -9.5 | -5.8 | 5.2e-09 | 0.77 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMB3 | 0.12 | 0.09 | lasso | 3 | 0.06 | 3.0e-03 | -9.0 | -9.3 | 1.0e-20 | 0.97 | 0.00 | 0.93 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB3 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.4e-05 | -9.5 | -9.5 | 2.5e-21 | 1.00 | 0.00 | 1.00 | FALSE |