[Hub]/) : Traits : Sitting height :

chr17:28,642,141-31,275,580

Best TWAS P=1.04e-15 · Best GWAS P=2.64e-15 conditioned to 2.51e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRRC37B 0.09 0.08 lasso 6 0.09 1.7e-11 6.4 6.5 8.6e-11 0.03 0.04 0.96 FALSE
2 CommonMind Brain Pre-frontal Cortex UTP6 0.08 0.08 lasso 3 0.08 4.3e-10 6.3 -6.5 1.0e-10 -0.05 0.12 0.88 FALSE
3 GTEx Artery Tibial UTP6 0.07 0.02 lasso 3 0.02 5.9e-03 6.6 -6.6 3.2e-11 -0.05 0.03 0.94 FALSE
4 GTEx Artery Tibial RHOT1 0.15 0.06 enet 31 0.10 1.8e-08 3.0 -5.3 1.2e-07 -0.03 0.11 0.88 FALSE
5 GTEx Artery Tibial RP11-848P1.7 0.54 0.00 lasso 10 0.02 7.3e-03 -4.8 -8.0 1.0e-15 0.47 0.02 0.14 TRUE
6 GTEx Brain Cortex LRRC37B 0.14 0.06 lasso 8 0.02 9.5e-02 6.6 6.6 4.5e-11 0.04 0.03 0.77 FALSE
7 GTEx Breast Mammary Tissue CTC-542B22.2 0.07 0.01 enet 8 0.03 1.7e-02 6.6 5.9 3.5e-09 0.06 0.04 0.90 FALSE
8 GTEx Cells EBV-transformed lymphocytes RHOT1 0.10 0.01 lasso 13 0.01 1.1e-01 6.6 -6.5 7.0e-11 -0.04 0.04 0.72 FALSE
9 GTEx Cells Transformed fibroblasts LRRC37B 0.09 0.05 lasso 5 0.05 9.7e-05 6.4 6.7 2.1e-11 0.04 0.04 0.95 FALSE
10 GTEx Cells Transformed fibroblasts CTC-542B22.2 0.12 0.03 lasso 6 0.05 2.1e-04 6.5 6.6 3.9e-11 0.04 0.03 0.97 FALSE
11 GTEx Colon Transverse RHOT1 0.12 0.00 enet 23 0.00 3.6e-01 6.6 -5.9 4.0e-09 -0.05 0.04 0.76 FALSE
12 GTEx Esophagus Mucosa RHOT1 0.07 0.00 lasso 14 0.00 1.5e-01 6.6 -6.2 5.4e-10 -0.04 0.03 0.50 FALSE
13 GTEx Esophagus Mucosa COPRS 0.23 0.21 enet 24 0.19 1.7e-12 6.7 -6.9 6.4e-12 -0.06 0.02 0.98 TRUE
14 GTEx Heart Left Ventricle COPRS 0.08 0.06 lasso 3 0.06 2.4e-04 5.1 -5.3 9.5e-08 -0.06 0.04 0.89 FALSE
15 GTEx Nerve Tibial COPRS 0.08 0.05 lasso 3 0.03 2.8e-03 5.6 -6.0 2.3e-09 -0.04 0.06 0.84 FALSE
16 GTEx Pancreas COPRS 0.14 0.12 lasso 1 0.07 7.2e-04 6.7 -6.7 1.8e-11 -0.05 0.02 0.96 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic COPRS 0.29 0.26 lasso 3 0.24 2.6e-13 6.7 -6.6 3.7e-11 -0.05 0.02 0.98 FALSE
18 GTEx Skin Sun Exposed Lower leg COPRS 0.18 0.15 enet 15 0.16 4.8e-13 6.7 -6.2 5.0e-10 -0.04 0.02 0.98 FALSE
19 GTEx Small Intestine Terminal Ileum RHOT1 0.19 0.01 enet 26 0.05 3.4e-02 6.4 -6.5 9.0e-11 -0.05 0.05 0.48 FALSE
20 GTEx Testis COPRS 0.31 0.26 enet 11 0.28 4.3e-13 6.5 6.5 6.4e-11 0.05 0.04 0.96 FALSE
21 GTEx Thyroid COPRS 0.17 0.00 enet 43 0.01 1.2e-01 5.6 -6.5 5.7e-11 0.13 0.04 0.20 FALSE
22 METSIM Adipose RHOT1 0.05 0.02 blup 336 0.06 1.0e-08 6.6 -6.3 2.9e-10 -0.03 0.05 0.95 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma C17orf79 0.02 0.03 lasso 4 0.02 8.7e-06 5.6 -6.0 1.6e-09 -0.04 0.02 0.97 FALSE
24 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C17orf79 0.04 0.01 blup 26 0.01 9.1e-03 6.6 -6.4 1.9e-10 -0.02 0.00 0.93 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma LRRC37B 0.07 0.10 enet 5 0.09 1.0e-10 6.6 6.5 5.8e-11 0.05 0.02 0.98 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma LRRC37B 0.02 0.02 blup 23 0.02 3.5e-03 6.4 6.5 5.7e-11 0.05 0.02 0.86 FALSE
27 The Cancer Genome Atlas Prostate Adenocarcinoma C17orf79 0.07 0.04 lasso 2 0.03 1.5e-04 6.5 -6.7 1.7e-11 -0.05 0.00 1.00 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma C17orf79 0.13 0.09 blup 26 0.10 2.4e-10 6.5 -6.6 4.0e-11 -0.07 0.00 1.00 FALSE