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chr17:28,642,141-31,275,580

Best TWAS P=1.04e-15 · Best GWAS P=2.64e-15 conditioned to 2.51e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRRC37B	0.09	0.08	lasso	6	0.09	1.7e-11	6.4	6.5	8.6e-11	0.03	0.04	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UTP6	0.08	0.08	lasso	3	0.08	4.3e-10	6.3	-6.5	1.0e-10	-0.05	0.12	0.88	FALSE
3	GTEx	Artery Tibial	UTP6	0.07	0.02	lasso	3	0.02	5.9e-03	6.6	-6.6	3.2e-11	-0.05	0.03	0.94	FALSE
4	GTEx	Artery Tibial	RHOT1	0.15	0.06	enet	31	0.10	1.8e-08	3.0	-5.3	1.2e-07	-0.03	0.11	0.88	FALSE
5	GTEx	Artery Tibial	RP11-848P1.7	0.54	0.00	lasso	10	0.02	7.3e-03	-4.8	-8.0	1.0e-15	0.47	0.02	0.14	TRUE
6	GTEx	Brain Cortex	LRRC37B	0.14	0.06	lasso	8	0.02	9.5e-02	6.6	6.6	4.5e-11	0.04	0.03	0.77	FALSE
7	GTEx	Breast Mammary Tissue	CTC-542B22.2	0.07	0.01	enet	8	0.03	1.7e-02	6.6	5.9	3.5e-09	0.06	0.04	0.90	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	RHOT1	0.10	0.01	lasso	13	0.01	1.1e-01	6.6	-6.5	7.0e-11	-0.04	0.04	0.72	FALSE
9	GTEx	Cells Transformed fibroblasts	LRRC37B	0.09	0.05	lasso	5	0.05	9.7e-05	6.4	6.7	2.1e-11	0.04	0.04	0.95	FALSE
10	GTEx	Cells Transformed fibroblasts	CTC-542B22.2	0.12	0.03	lasso	6	0.05	2.1e-04	6.5	6.6	3.9e-11	0.04	0.03	0.97	FALSE
11	GTEx	Colon Transverse	RHOT1	0.12	0.00	enet	23	0.00	3.6e-01	6.6	-5.9	4.0e-09	-0.05	0.04	0.76	FALSE
12	GTEx	Esophagus Mucosa	RHOT1	0.07	0.00	lasso	14	0.00	1.5e-01	6.6	-6.2	5.4e-10	-0.04	0.03	0.50	FALSE
13	GTEx	Esophagus Mucosa	COPRS	0.23	0.21	enet	24	0.19	1.7e-12	6.7	-6.9	6.4e-12	-0.06	0.02	0.98	TRUE
14	GTEx	Heart Left Ventricle	COPRS	0.08	0.06	lasso	3	0.06	2.4e-04	5.1	-5.3	9.5e-08	-0.06	0.04	0.89	FALSE
15	GTEx	Nerve Tibial	COPRS	0.08	0.05	lasso	3	0.03	2.8e-03	5.6	-6.0	2.3e-09	-0.04	0.06	0.84	FALSE
16	GTEx	Pancreas	COPRS	0.14	0.12	lasso	1	0.07	7.2e-04	6.7	-6.7	1.8e-11	-0.05	0.02	0.96	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	COPRS	0.29	0.26	lasso	3	0.24	2.6e-13	6.7	-6.6	3.7e-11	-0.05	0.02	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	COPRS	0.18	0.15	enet	15	0.16	4.8e-13	6.7	-6.2	5.0e-10	-0.04	0.02	0.98	FALSE
19	GTEx	Small Intestine Terminal Ileum	RHOT1	0.19	0.01	enet	26	0.05	3.4e-02	6.4	-6.5	9.0e-11	-0.05	0.05	0.48	FALSE
20	GTEx	Testis	COPRS	0.31	0.26	enet	11	0.28	4.3e-13	6.5	6.5	6.4e-11	0.05	0.04	0.96	FALSE
21	GTEx	Thyroid	COPRS	0.17	0.00	enet	43	0.01	1.2e-01	5.6	-6.5	5.7e-11	0.13	0.04	0.20	FALSE
22	METSIM	Adipose	RHOT1	0.05	0.02	blup	336	0.06	1.0e-08	6.6	-6.3	2.9e-10	-0.03	0.05	0.95	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf79	0.02	0.03	lasso	4	0.02	8.7e-06	5.6	-6.0	1.6e-09	-0.04	0.02	0.97	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf79	0.04	0.01	blup	26	0.01	9.1e-03	6.6	-6.4	1.9e-10	-0.02	0.00	0.93	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC37B	0.07	0.10	enet	5	0.09	1.0e-10	6.6	6.5	5.8e-11	0.05	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	LRRC37B	0.02	0.02	blup	23	0.02	3.5e-03	6.4	6.5	5.7e-11	0.05	0.02	0.86	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	C17orf79	0.07	0.04	lasso	2	0.03	1.5e-04	6.5	-6.7	1.7e-11	-0.05	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf79	0.13	0.09	blup	26	0.10	2.4e-10	6.5	-6.6	4.0e-11	-0.07	0.00	1.00	FALSE