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chr19:45,585,167-46,994,833

Best TWAS P=4.33e-15 · Best GWAS P=8.63e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	DMWD	0.11	0.13	lasso	2	0.16	7.3e-09	6.6	7.7	1.3e-14	-0.85	0.04	0.96	FALSE
2	GTEx	Artery Aorta	DMWD	0.28	0.19	lasso	3	0.15	1.2e-08	-7.3	7.3	4.0e-13	-0.94	0.02	0.98	FALSE
3	GTEx	Artery Tibial	DMWD	0.22	0.17	lasso	8	0.16	6.8e-13	-7.3	7.7	1.7e-14	-0.97	0.01	0.99	FALSE
4	GTEx	Artery Tibial	AC074212.6	0.14	0.04	lasso	5	0.06	2.4e-05	-7.7	5.8	7.8e-09	-0.87	0.01	0.99	FALSE
5	GTEx	Lung	DMPK	0.10	0.05	lasso	3	0.05	5.4e-05	6.6	7.5	5.3e-14	-0.77	0.04	0.96	FALSE
6	GTEx	Muscle Skeletal	DMWD	0.06	0.01	lasso	6	0.01	1.9e-02	-7.3	7.0	2.8e-12	-0.91	0.01	0.97	FALSE
7	GTEx	Nerve Tibial	DMWD	0.24	0.07	lasso	6	0.06	5.8e-05	-7.3	7.1	1.1e-12	-0.86	0.03	0.97	FALSE
8	GTEx	Skin Sun Exposed Lower leg	DMPK	0.13	0.08	lasso	3	0.07	2.5e-06	6.6	6.6	3.2e-11	-0.60	0.80	0.20	FALSE
9	GTEx	Skin Sun Exposed Lower leg	DMWD	0.10	0.07	lasso	4	0.07	4.1e-06	6.6	6.4	1.3e-10	-0.59	0.19	0.78	FALSE
10	GTEx	Skin Sun Exposed Lower leg	AC074212.6	0.13	0.08	enet	27	0.08	7.2e-07	6.6	6.5	7.6e-11	-0.58	0.15	0.84	FALSE
11	GTEx	Testis	DMPK	0.19	0.11	lasso	4	0.07	3.2e-04	5.2	5.7	1.4e-08	-0.44	0.57	0.17	FALSE
12	GTEx	Testis	DMWD	0.19	0.15	lasso	3	0.13	2.7e-06	6.7	6.7	2.7e-11	-0.60	0.56	0.29	FALSE
13	GTEx	Thyroid	DMPK	0.13	0.11	lasso	2	0.12	1.3e-09	6.6	7.5	6.8e-14	-0.78	0.21	0.79	FALSE
14	GTEx	Thyroid	DMWD	0.11	0.12	lasso	3	0.11	6.7e-09	6.6	7.7	1.5e-14	-0.83	0.03	0.97	FALSE
15	GTEx	Thyroid	AC074212.6	0.08	0.10	lasso	2	0.09	1.8e-07	-7.3	7.3	2.1e-13	-0.95	0.02	0.98	FALSE
16	GTEx	Whole Blood	DMPK	0.07	0.04	lasso	5	0.02	2.2e-03	6.6	6.3	2.2e-10	-0.55	0.15	0.73	FALSE
17	GTEx	Whole Blood	AC074212.6	0.07	0.04	lasso	3	0.02	4.2e-03	6.6	6.3	3.9e-10	-0.57	0.11	0.80	FALSE
18	YFS	Blood	DMWD	0.06	0.04	enet	19	0.05	3.8e-15	6.6	5.7	1.3e-08	-0.46	0.91	0.09	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	DMWD	0.01	0.00	blup	42	0.01	7.3e-03	1.9	-6.7	2.1e-11	0.83	0.01	0.80	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	FOXA3	0.03	0.02	blup	53	0.02	1.9e-04	-7.8	6.6	3.6e-11	-0.77	0.00	0.99	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SIX5	0.05	0.05	lasso	8	0.03	7.6e-03	-7.5	-7.8	4.3e-15	0.98	0.01	0.95	TRUE