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chr19:41,165,252-43,237,764

Best TWAS P=1.09e-18 · Best GWAS P=7.51e-19 conditioned to 0.025

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ATP5SL	0.34	0.48	bslmm	365	0.48	1.5e-65	8.6	-8.5	2.1e-17	-0.94	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	BCKDHA	0.12	0.08	lasso	6	0.10	8.9e-13	8.7	-7.5	7.8e-14	-0.91	0.02	0.98	FALSE
3	GTEx	Artery Aorta	ATP5SL	0.14	0.00	lasso	2	0.01	1.6e-01	8.5	-8.5	2.8e-17	-0.93	0.03	0.49	FALSE
4	GTEx	Artery Aorta	B3GNT8	0.14	0.09	lasso	2	0.08	2.6e-05	8.6	7.9	3.9e-15	0.92	0.03	0.97	FALSE
5	GTEx	Artery Aorta	CTC-435M10.6	0.16	0.14	lasso	3	0.13	1.3e-07	8.7	8.6	6.5e-18	0.95	0.03	0.97	FALSE
6	GTEx	Brain Cerebellar Hemisphere	B3GNT8	0.38	0.30	lasso	5	0.23	1.1e-06	8.6	8.6	5.2e-18	0.93	0.02	0.98	FALSE
7	GTEx	Brain Cerebellar Hemisphere	CTC-435M10.6	0.29	0.20	lasso	4	0.18	2.6e-05	8.6	8.7	2.3e-18	0.96	0.02	0.96	FALSE
8	GTEx	Brain Cerebellum	B3GNT8	0.28	0.23	lasso	5	0.21	9.2e-07	8.6	8.6	7.5e-18	0.95	0.03	0.97	FALSE
9	GTEx	Brain Cerebellum	CTC-435M10.6	0.18	0.01	lasso	4	0.03	5.1e-02	8.6	8.6	9.4e-18	0.84	0.03	0.80	FALSE
10	GTEx	Brain Frontal Cortex BA9	ATP5SL	0.28	0.15	lasso	3	0.10	1.0e-03	8.5	-8.4	3.7e-17	-0.94	0.03	0.92	FALSE
11	GTEx	Cells Transformed fibroblasts	TMEM91	0.08	0.00	enet	31	0.01	7.4e-02	3.3	5.4	6.3e-08	0.52	0.04	0.73	FALSE
12	GTEx	Cells Transformed fibroblasts	B3GNT8	0.10	0.02	lasso	2	0.03	2.0e-03	8.5	8.4	4.8e-17	0.93	0.05	0.95	FALSE
13	GTEx	Cells Transformed fibroblasts	CTC-435M10.6	0.18	0.16	lasso	2	0.15	4.2e-11	8.5	8.3	1.4e-16	0.91	0.03	0.97	FALSE
14	GTEx	Colon Transverse	B3GNT8	0.21	0.17	lasso	4	0.18	6.7e-09	8.5	8.3	8.0e-17	0.93	0.05	0.95	FALSE
15	GTEx	Colon Transverse	CTC-435M10.6	0.26	0.19	enet	19	0.22	5.8e-11	8.4	7.9	1.9e-15	0.86	0.04	0.96	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	CTC-435M10.6	0.23	0.10	enet	17	0.10	1.7e-04	8.6	6.8	1.1e-11	0.84	0.03	0.93	FALSE
17	GTEx	Esophagus Muscularis	B3GNT8	0.14	0.10	lasso	2	0.16	7.5e-10	-4.4	6.6	3.1e-11	0.85	0.04	0.96	FALSE
18	GTEx	Esophagus Muscularis	CTC-435M10.6	0.12	0.12	lasso	2	0.10	1.4e-06	8.3	8.2	1.7e-16	0.91	0.04	0.96	FALSE
19	GTEx	Heart Atrial Appendage	TMEM91	0.12	0.05	lasso	4	0.08	1.7e-04	5.7	5.6	1.6e-08	0.55	0.05	0.70	FALSE
20	GTEx	Heart Left Ventricle	CTC-435M10.6	0.18	0.02	lasso	4	0.06	4.8e-04	8.4	6.4	1.1e-10	0.80	0.02	0.97	FALSE
21	GTEx	Lung	CTC-435M10.6	0.13	0.11	lasso	3	0.10	3.3e-08	8.5	8.5	2.4e-17	0.93	0.04	0.96	FALSE
22	GTEx	Muscle Skeletal	EXOSC5	0.07	0.03	enet	6	0.03	4.1e-04	8.6	8.6	7.4e-18	0.95	0.01	0.99	FALSE
23	GTEx	Nerve Tibial	B9D2	0.13	0.08	lasso	4	0.06	2.9e-05	5.1	6.0	1.7e-09	0.68	0.08	0.82	FALSE
24	GTEx	Nerve Tibial	B3GNT8	0.22	0.17	enet	12	0.20	6.6e-14	8.3	7.6	3.3e-14	0.91	0.04	0.96	FALSE
25	GTEx	Nerve Tibial	CTC-435M10.6	0.18	0.15	lasso	6	0.14	5.5e-10	8.3	8.6	6.7e-18	0.94	0.02	0.98	FALSE
26	GTEx	Skin Sun Exposed Lower leg	B3GNT8	0.11	0.04	lasso	6	0.05	1.1e-04	-4.4	7.0	2.2e-12	0.87	0.03	0.97	FALSE
27	GTEx	Stomach	B3GNT8	0.22	0.14	lasso	7	0.12	1.4e-06	8.5	8.4	3.4e-17	0.93	0.02	0.98	FALSE
28	GTEx	Stomach	CTC-435M10.6	0.23	0.14	lasso	11	0.13	1.0e-06	8.3	7.7	1.1e-14	0.91	0.02	0.98	FALSE
29	GTEx	Testis	EXOSC5	0.31	0.33	enet	10	0.33	1.8e-15	8.4	8.5	1.2e-17	0.95	0.04	0.96	FALSE
30	GTEx	Testis	GRIK5	0.41	0.24	lasso	10	0.24	7.9e-11	-5.8	6.0	1.6e-09	0.02	0.01	0.99	TRUE
31	GTEx	Thyroid	EXOSC5	0.14	0.08	lasso	5	0.05	8.4e-05	8.6	8.4	6.3e-17	0.92	0.04	0.94	FALSE
32	GTEx	Thyroid	B3GNT8	0.09	0.04	enet	17	0.03	1.4e-03	8.6	6.8	1.1e-11	0.82	0.01	0.97	FALSE
33	GTEx	Thyroid	CTC-435M10.6	0.07	0.03	lasso	2	0.04	7.9e-04	8.6	6.8	7.8e-12	0.83	0.02	0.97	FALSE
34	YFS	Blood	ATP5SL	0.06	0.02	lasso	12	0.03	1.1e-09	8.9	8.3	1.3e-16	0.85	0.01	0.99	FALSE
35	YFS	Blood	BCKDHA	0.08	0.05	enet	27	0.06	1.9e-18	8.7	-7.4	1.4e-13	-0.84	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	B3GNT8	0.03	0.04	blup	20	0.04	3.2e-04	8.5	8.4	3.8e-17	0.94	0.01	0.96	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	BCKDHA	0.02	0.02	lasso	2	0.02	1.5e-02	8.6	-8.6	7.7e-18	-0.94	0.01	0.83	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	B3GNT8	0.04	0.07	blup	20	0.07	1.2e-13	8.4	8.3	1.6e-16	0.94	0.03	0.97	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	B3GNT8	0.09	0.13	blup	20	0.11	5.2e-07	8.3	8.1	7.2e-16	0.93	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BCKDHA	0.03	0.03	enet	4	0.03	1.8e-04	-4.4	-5.4	8.5e-08	-0.72	0.03	0.78	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DEDD2	0.02	0.02	lasso	1	0.01	3.1e-02	-5.8	5.8	8.1e-09	0.01	0.01	0.95	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ATP5SL	0.04	0.03	enet	12	0.03	1.6e-04	8.8	-7.9	2.1e-15	-0.88	0.00	0.99	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATP5SL	0.02	0.03	enet	4	0.02	7.0e-04	8.6	-8.6	1.0e-17	-0.94	0.02	0.90	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	EXOSC5	0.04	0.03	lasso	2	0.02	5.8e-03	8.6	8.1	3.7e-16	0.91	0.01	0.70	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	RABAC1	0.01	0.01	enet	2	0.01	1.8e-02	-4.8	5.3	9.5e-08	0.03	0.00	0.44	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	B3GNT8	0.15	0.12	blup	20	0.12	1.3e-05	-4.4	6.7	2.5e-11	0.86	0.03	0.93	FALSE
47	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ATP5SL	0.23	0.05	blup	18	0.05	4.5e-03	8.8	-8.8	1.1e-18	-0.86	0.01	0.86	TRUE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATP5SL	0.03	0.03	blup	18	0.03	4.1e-04	8.8	-8.7	3.8e-18	-0.94	0.01	0.94	FALSE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	B3GNT8	0.39	0.08	blup	20	0.07	1.1e-02	8.6	7.9	2.1e-15	0.81	0.00	0.30	FALSE
50	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSK3A	0.15	0.10	lasso	7	0.09	4.0e-03	-5.7	-5.7	9.3e-09	-0.01	0.00	0.55	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	ATP5SL	0.02	0.02	blup	18	0.02	3.5e-03	8.8	-8.4	3.1e-17	-0.94	0.01	0.82	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	B3GNT8	0.10	0.12	lasso	3	0.11	1.3e-10	8.6	7.8	4.6e-15	0.92	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC5	0.02	0.01	blup	31	0.03	4.5e-04	8.5	7.7	1.1e-14	0.92	0.01	0.94	FALSE