[Hub]/) : Traits : Sitting height :

chr22:21,075,537-22,913,629

Best TWAS P=3.56e-16 · Best GWAS P=1.78e-15 conditioned to 0.191

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex UBE2L3 0.10 0.12 enet 16 0.11 9.7e-14 -7.8 -8.1 5.3e-16 0.97 0.04 0.96 FALSE
2 GTEx Adipose Subcutaneous CCDC116 0.15 0.12 lasso 7 0.13 1.7e-10 -7.8 7.4 1.5e-13 -0.98 0.06 0.94 FALSE
3 GTEx Adipose Visceral Omentum CCDC116 0.09 0.05 lasso 3 0.03 1.4e-02 -7.9 7.8 6.2e-15 -0.99 0.02 0.96 FALSE
4 GTEx Artery Aorta CCDC116 0.18 0.18 lasso 10 0.18 5.5e-10 -7.8 7.8 5.2e-15 -0.99 0.03 0.97 FALSE
5 GTEx Artery Coronary CCDC116 0.16 0.06 lasso 4 0.09 5.6e-04 -8.0 7.7 1.2e-14 -0.97 0.02 0.95 FALSE
6 GTEx Artery Tibial CCDC116 0.14 0.15 lasso 5 0.14 2.7e-11 -7.7 7.9 3.6e-15 -0.99 0.05 0.95 FALSE
7 GTEx Brain Cerebellum CCDC116 0.25 0.16 lasso 4 0.10 6.5e-04 -7.9 8.0 1.7e-15 -0.98 0.02 0.96 FALSE
8 GTEx Brain Cortex CCDC116 0.17 0.17 lasso 2 0.15 7.3e-05 -7.8 7.8 7.7e-15 -0.99 0.03 0.91 FALSE
9 GTEx Breast Mammary Tissue CCDC116 0.15 0.12 enet 20 0.13 5.1e-07 -7.8 6.0 2.3e-09 -0.84 0.03 0.96 FALSE
10 GTEx Breast Mammary Tissue (Female) CCDC116 0.11 -0.01 enet 15 -0.01 5.7e-01 -7.9 6.5 8.9e-11 -0.84 0.02 0.72 FALSE
11 GTEx Colon Sigmoid CCDC116 0.30 0.14 lasso 5 0.24 6.0e-09 -2.0 6.0 2.3e-09 -0.85 0.03 0.97 FALSE
12 GTEx Colon Transverse CCDC116 0.15 0.03 enet 16 0.04 6.3e-03 -6.9 6.3 3.6e-10 -0.80 0.02 0.87 FALSE
13 GTEx Esophagus Gastroesophageal Junction CCDC116 0.20 0.08 lasso 8 0.12 6.0e-05 -7.9 7.8 4.6e-15 -0.99 0.02 0.97 FALSE
14 GTEx Esophagus Mucosa CCDC116 0.10 0.06 lasso 4 0.06 8.7e-05 -7.8 7.9 4.0e-15 -1.00 0.02 0.98 FALSE
15 GTEx Esophagus Muscularis CCDC116 0.15 0.20 lasso 1 0.19 6.5e-12 -7.8 7.8 9.0e-15 -0.99 0.04 0.96 FALSE
16 GTEx Heart Atrial Appendage CCDC116 0.11 0.03 lasso 3 0.05 1.8e-03 -7.9 7.8 4.4e-15 -0.96 0.02 0.95 FALSE
17 GTEx Lung CCDC116 0.12 0.15 lasso 2 0.14 5.3e-11 -7.7 7.8 8.7e-15 -0.98 0.06 0.94 FALSE
18 GTEx Nerve Tibial CCDC116 0.22 0.25 enet 9 0.29 1.8e-20 -7.7 7.9 3.6e-15 -0.99 0.05 0.95 FALSE
19 GTEx Ovary CCDC116 0.54 0.15 lasso 10 0.20 1.5e-05 -7.7 6.1 1.4e-09 -0.84 0.04 0.74 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic CCDC116 0.12 0.05 lasso 5 0.02 2.1e-02 -7.8 7.1 1.5e-12 -0.96 0.03 0.91 FALSE
21 GTEx Skin Sun Exposed Lower leg CCDC116 0.07 0.08 enet 8 0.08 6.6e-07 -7.7 6.5 1.0e-10 -0.90 0.05 0.94 FALSE
22 GTEx Spleen CCDC116 0.20 0.07 enet 15 0.14 1.8e-04 -7.7 7.1 8.8e-13 -0.89 0.03 0.87 FALSE
23 GTEx Thyroid CCDC116 0.10 0.07 lasso 4 0.07 3.7e-06 -7.7 7.8 7.3e-15 -0.99 0.03 0.97 FALSE
24 GTEx Thyroid HIC2 0.07 0.00 lasso 4 0.00 5.9e-01 -7.8 -7.9 2.9e-15 0.99 0.03 0.64 FALSE
25 GTEx Whole Blood UBE2L3 0.06 0.00 enet 22 0.01 4.0e-02 -7.9 -5.6 1.9e-08 0.75 0.02 0.91 FALSE
26 METSIM Adipose CCDC116 0.06 0.07 enet 22 0.08 4.6e-12 -7.9 7.5 5.9e-14 -0.94 0.03 0.97 FALSE
27 METSIM Adipose YDJC 0.05 0.04 enet 11 0.04 7.7e-07 -7.9 -7.1 1.2e-12 0.77 0.02 0.98 FALSE
28 NTR Blood MAPK1 0.01 0.00 blup 384 0.00 4.7e-02 2.1 -5.1 2.8e-07 0.35 0.10 0.04 FALSE
29 YFS Blood UBE2L3 0.13 0.25 bslmm 330 0.25 1.3e-82 -7.9 -7.9 3.6e-15 0.99 0.02 0.98 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma CCDC116 0.03 0.02 enet 12 0.02 5.1e-03 -7.1 5.8 5.0e-09 -0.84 0.01 0.74 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma CCDC116 0.04 0.04 blup 40 0.05 1.1e-09 -7.7 6.8 1.4e-11 -0.87 0.02 0.98 FALSE
32 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCDC116 0.05 0.06 lasso 1 0.05 1.3e-03 -7.1 7.1 9.4e-13 -0.96 0.02 0.83 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma CCDC116 0.05 0.00 blup 40 0.02 1.8e-02 -6.0 8.2 3.6e-16 -0.91 0.01 0.55 TRUE
34 The Cancer Genome Atlas Glioblastoma Multiforme CCDC116 0.10 0.06 blup 39 0.07 4.4e-03 -7.1 7.4 1.8e-13 -0.96 0.02 0.81 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC116 0.02 0.02 lasso 2 0.02 1.4e-03 -7.9 7.8 6.7e-15 -0.96 0.01 0.86 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPIL2 0.07 0.06 blup 61 0.06 6.1e-07 -3.3 -6.4 2.1e-10 0.51 0.92 0.03 FALSE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma YDJC 0.04 0.00 blup 34 0.02 4.0e-02 -7.9 -6.9 7.3e-12 0.94 0.01 0.67 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma CCDC116 0.07 0.12 blup 40 0.11 1.2e-12 -7.9 7.9 3.0e-15 -0.96 0.01 0.99 FALSE
39 The Cancer Genome Atlas Brain Lower Grade Glioma YDJC 0.08 0.14 blup 34 0.15 2.9e-16 -7.7 -7.7 1.3e-14 0.97 0.02 0.98 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PPIL2 0.03 0.00 blup 61 0.02 4.4e-03 -6.0 -5.9 3.6e-09 0.57 0.02 0.33 FALSE
41 The Cancer Genome Atlas Pancreatic Adenocarcinoma CCDC116 0.07 0.02 blup 40 0.03 1.5e-02 -7.7 7.6 3.2e-14 -0.96 0.02 0.77 FALSE
42 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CCDC116 0.11 0.14 enet 14 0.12 2.3e-05 -8.0 8.0 1.5e-15 -0.99 0.02 0.98 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma CCDC116 0.06 0.05 blup 40 0.06 4.3e-07 -7.7 6.9 5.1e-12 -0.90 0.02 0.98 FALSE
44 The Cancer Genome Atlas Prostate Adenocarcinoma PPIL2 0.04 0.05 enet 7 0.03 5.9e-04 -3.3 -5.9 4.0e-09 0.50 0.27 0.44 FALSE
45 The Cancer Genome Atlas Thyroid Carcinoma CCDC116 0.05 0.07 blup 40 0.07 4.6e-07 -7.9 8.1 5.6e-16 -0.97 0.02 0.98 FALSE