Best TWAS P=1.21e-28 · Best GWAS P=1.55e-30 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF638 | 0.06 | 0.01 | bslmm | 559 | 0.02 | 1.8e-03 | 11.4 | 6.4 | 1.9e-10 | 0.69 | 0.01 | 0.96 | FALSE |
2 | GTEx | Adipose Subcutaneous | PAIP2B | 0.14 | 0.06 | enet | 23 | 0.05 | 8.7e-05 | 4.8 | 5.6 | 2.6e-08 | 0.37 | 0.94 | 0.01 | FALSE |
3 | GTEx | Artery Aorta | ZNF638 | 0.25 | 0.07 | enet | 20 | 0.10 | 5.2e-06 | 11.4 | 11.1 | 1.2e-28 | 0.98 | 0.01 | 0.99 | TRUE |
4 | GTEx | Artery Aorta | PAIP2B | 0.09 | 0.02 | lasso | 3 | 0.02 | 3.0e-02 | 5.4 | 5.5 | 3.9e-08 | 0.59 | 0.28 | 0.04 | FALSE |
5 | GTEx | Artery Tibial | ZNF638 | 0.10 | 0.06 | enet | 13 | 0.07 | 2.4e-06 | 11.3 | 9.6 | 1.3e-21 | 0.88 | 0.01 | 0.98 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | FAM136A | 0.31 | 0.12 | lasso | 7 | 0.16 | 5.6e-06 | 4.5 | 5.5 | 4.0e-08 | 0.02 | 0.04 | 0.92 | TRUE |
7 | GTEx | Skin Sun Exposed Lower leg | PAIP2B | 0.14 | 0.07 | enet | 39 | 0.07 | 3.0e-06 | 8.5 | 7.3 | 3.4e-13 | 0.66 | 0.33 | 0.63 | FALSE |
8 | GTEx | Thyroid | ZNF638 | 0.11 | 0.04 | enet | 13 | 0.06 | 1.3e-05 | 4.1 | 5.8 | 6.4e-09 | 0.66 | 0.07 | 0.91 | FALSE |
9 | METSIM | Adipose | PAIP2B | 0.05 | 0.03 | lasso | 9 | 0.03 | 5.0e-05 | 8.5 | 7.6 | 2.3e-14 | 0.75 | 0.60 | 0.33 | FALSE |
10 | NTR | Blood | PAIP2B | 0.03 | 0.02 | lasso | 5 | 0.01 | 1.2e-04 | -3.4 | -5.2 | 2.0e-07 | -0.38 | 0.89 | 0.02 | FALSE |
11 | The Cancer Genome Atlas | Esophageal Carcinoma | ZNF638 | 0.12 | 0.08 | lasso | 1 | 0.07 | 2.2e-03 | 7.8 | 7.8 | 6.3e-15 | 0.76 | 0.05 | 0.66 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF638 | 0.08 | 0.05 | enet | 10 | 0.05 | 5.6e-06 | 11.4 | 9.2 | 5.4e-20 | 0.88 | 0.01 | 0.99 | FALSE |