TWAS hub - PAIP2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1410	0.0410	2.9e-05	0.062	NA	0.048	NA	0.041	8.1e-06	NA	8.7e-05	NA	2.5e-04
2	GTEx	Artery Aorta	0.0930	0.0390	8.1e-03	0.018	NA	0.006	NA	0.019	3.3e-02	NA	1.4e-01	NA	3.0e-02
3	GTEx	Artery Tibial	0.1019	0.0384	2.2e-03	0.053	NA	0.042	NA	0.053	5.2e-05	NA	3.0e-04	NA	5.5e-05
4	GTEx	Brain Cerebellum	0.3290	0.1140	9.3e-03	0.178	NA	0.085	NA	0.123	6.1e-06	NA	1.7e-03	NA	1.8e-04
5	GTEx	Esophagus Muscularis	0.1560	0.0540	9.2e-04	0.070	NA	0.031	NA	0.034	4.8e-05	NA	5.5e-03	NA	3.5e-03
6	GTEx	Lung	0.1021	0.0365	1.4e-03	0.073	NA	0.051	NA	0.062	2.9e-06	NA	9.0e-05	NA	1.7e-05
7	GTEx	Nerve Tibial	0.1052	0.0378	1.4e-03	0.077	NA	0.067	NA	0.075	3.8e-06	NA	1.7e-05	NA	5.5e-06
8	GTEx	Pancreas	0.1770	0.0680	6.8e-03	0.026	NA	-0.005	NA	0.010	2.7e-02	NA	6.5e-01	NA	1.1e-01
9	GTEx	Skin Not Sun Exposed Suprapubic	0.1460	0.0500	1.3e-03	0.002	NA	-0.002	NA	0.004	2.6e-01	NA	4.2e-01	NA	1.8e-01
10	GTEx	Skin Sun Exposed Lower leg	0.1440	0.0420	1.4e-05	0.073	NA	0.067	NA	0.057	1.2e-06	NA	3.0e-06	NA	1.6e-05
11	GTEx	Spleen	0.3560	0.1210	3.2e-03	-0.007	NA	0.070	NA	0.062	5.4e-01	NA	7.4e-03	NA	1.1e-02
12	GTEx	Stomach	0.1390	0.0530	5.5e-03	0.126	NA	0.029	NA	0.094	1.3e-06	NA	1.5e-02	NA	2.8e-05
13	GTEx	Thyroid	0.1120	0.0400	6.0e-04	0.064	NA	0.025	NA	0.039	1.2e-05	NA	4.6e-03	NA	5.4e-04
14	METSIM	Adipose	0.0519	0.0188	3.7e-04	0.027	0.019	0.025	0.023	0.027	5.5e-05	5.7e-04	1.1e-04	2.0e-04	5.0e-05
15	NTR	Blood	0.0290	0.0100	2.5e-04	0.019	0.004	0.007	0.008	0.011	4.8e-07	2.0e-02	1.6e-03	7.3e-04	1.2e-04
16	ROSMAP	Brain Pre-frontal Cortex	0.0657	0.0231	1.0e-04	0.039	0.040	0.027	0.039	0.034	7.8e-06	5.6e-06	2.0e-04	8.1e-06	3.3e-05
17	TCGA	Breast Invasive Carcinoma	0.0542	0.0216	1.1e-08	0.047	0.045	0.041	NA	0.049	6.4e-10	1.1e-09	8.3e-09	NA	2.2e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Supplements: Zinc	6.2	6.7	17.5	1.7	2.9	2.7	0.4	3.6	3.6	3.5	2.4	4.0	2.7	1.3	1.5	4.2	1.6	0.9	1.9	0.5
Reaction Time	4.4	8.4	22.4	2.6	3.3	2.8	-2.0	2.4	2.7	2.7	2.8	2.6	3.6	1.2	3.2	2.4	4.2	-4.7	2.5	-1.1
Hearing difficulty/problems: Yes	3.9	6.0	11.6	1.9	3.4	2.6	-0.3	2.7	2.9	2.8	2.8	3.0	2.6	1.3	2.8	2.9	3.0	0.3	0.7	-2.1
Family relationship satisfaction	3.9	4.7	9.0	2.0	3.0	2.3	0.0	2.4	2.4	2.5	2.2	1.1	1.8	2.4	2.8	2.4	2.9	1.1	2.4	-0.2
Standing height	3.7	36.9	97.4	6.4	7.1	6.2	0.1	6.8	6.3	6.4	6.3	3.6	8.7	1.0	5.8	6.5	9.9	-5.4	6.1	1.2
Bipolar Disorder (2011)	3.6	3.5	7.6	1.2	1.7	2.4	0.0	1.8	2.0	2.1	2.8	1.8	1.8	0.4	2.7	1.7	2.2	-0.4	2.3	-1.6
Height	3.5	68.3	182.2	8.9	9.5	8.9	-0.6	8.5	8.3	8.1	9.0	5.1	12.1	-0.1	7.0	8.1	13.5	-8.0	9.3	2.0
Age when periods started (menarche)	3.5	8.3	17.1	3.1	3.2	3.5	-0.5	3.3	3.2	3.3	3.7	1.3	2.4	2.2	3.8	2.8	4.1	-0.5	3.3	0.1
Friendships satisfaction	3.4	4.2	11.5	1.3	2.5	2.1	0.4	3.0	2.9	2.9	1.8	1.7	0.9	1.6	1.9	3.4	1.8	1.5	1.7	0.5
Bipolar Disorder or Schizophrenia	3.3	8.1	16.8	3.1	3.5	3.0	-1.2	3.0	3.0	2.9	3.1	2.4	4.1	-0.0	2.6	3.0	3.0	-2.7	3.6	-1.1
Father’s age at death	3.3	4.5	10.0	2.9	2.0	2.9	-1.1	2.6	2.6	2.7	2.9	0.6	0.3	0.8	3.2	2.3	1.3	1.3	2.3	-0.5
Qualifications: CSEs or equivalent	3.2	4.3	9.5	2.9	1.5	2.8	1.9	2.3	2.5	2.4	3.1	-0.0	1.4	-0.8	2.4	2.1	2.1	-1.0	1.9	1.8
Sitting height	3.2	22.7	58.2	5.6	5.5	4.6	-0.1	5.1	4.7	4.7	4.7	3.5	7.3	1.0	4.4	4.9	7.6	-5.2	4.2	0.2
Number of full brothers	3.2	4.1	7.3	-2.5	-2.6	-2.2	-1.8	-2.1	-2.5	-2.6	-2.2	-0.8	-1.6	-1.3	-2.4	-2.7	-1.5	-1.0	-1.6	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	6.1	2.4	2.5	2.1	-0.1	2.2	2.3	2.3	1.9	0.8	2.1	1.0	2.3	2.3	2.1	-1.6	2.1	-0.3
Forced vital capacity (FVC), Best measure	3.1	11.3	22.8	3.7	4.0	3.7	-0.2	4.0	3.9	3.8	3.7	2.9	4.8	-0.6	2.3	4.1	4.6	-3.0	2.5	0.1
Had menopause	3.0	3.8	8.1	-2.3	-1.6	-2.4	-0.4	-1.8	-2.1	-2.1	-2.3	-1.7	-1.6	-2.8	-2.1	-1.7	-1.8	1.2	-2.4	1.5
Bipolar Disorder (2018)	2.8	4.5	9.8	2.3	2.0	2.4	-1.7	2.4	2.4	2.4	2.4	2.4	2.3	0.2	1.6	2.4	1.6	-0.6	3.1	-1.9
Comparative body size at age 10	2.8	7.7	14.3	-3.5	-2.5	-3.4	-1.1	-3.8	-3.6	-3.6	-3.4	-2.4	-2.1	-1.0	-2.6	-3.7	-2.8	0.9	-2.8	0.1
Diabetes (father)	2.7	3.4	8.2	0.8	2.7	1.7	1.7	2.3	2.3	2.4	1.4	2.5	1.7	1.1	2.1	2.9	1.3	-0.0	0.8	-0.2
Osteoarthritis (self-reported)	2.7	3.5	6.9	-1.7	-0.3	-2.6	-0.9	-2.6	-2.5	-2.4	-2.3	-2.1	-0.7	-1.5	-0.8	-2.2	-0.8	-2.3	-2.2	-1.3
Heel T-Score	2.6	20.5	38.2	-4.9	-5.6	-4.8	-1.9	-5.4	-5.2	-5.2	-5.0	-3.9	-5.3	-2.3	-4.1	-5.5	-6.2	2.5	-4.0	-1.6
Hearing difficulty/problems with background noise	2.6	4.2	7.3	1.5	2.4	2.4	-0.8	2.7	2.6	2.6	2.5	2.5	1.4	0.9	2.2	2.5	2.1	0.9	1.5	-0.8
Alzheimer’s Disease (including proxy)	2.4	3.5	10.4	2.1	1.3	1.9	-0.2	1.8	1.7	1.7	2.2	1.7	3.2	0.6	1.8	1.5	1.4	-2.6	2.8	-0.8
Comparative height size at age 10	2.4	13.3	52.3	3.9	4.6	3.3	0.7	3.4	3.1	3.2	3.6	1.1	6.0	0.3	3.1	3.3	7.2	-3.5	3.3	0.9
Intelligence (Savage-Jansen 2018)	2.3	7.0	14.8	-2.1	-2.4	-2.5	0.5	-2.8	-2.7	-2.6	-2.6	-1.0	-3.7	3.3	-2.2	-2.8	-3.8	2.2	-1.7	-3.5
Fasting Glucose	2.3	2.8	5.2	1.6	1.6	2.3	-2.0	2.1	2.0	1.9	1.8	1.4	2.2	-0.6	2.0	1.7	1.4	-0.5	1.2	-0.0
Trunk fat-free mass	2.3	13.1	31.9	3.1	4.7	3.3	-0.4	4.0	3.6	3.8	3.4	2.3	5.2	0.8	3.6	3.9	5.7	-4.7	3.3	-0.1
Trunk predicted mass	2.3	13.0	31.4	3.1	4.6	3.4	-0.3	4.0	3.6	3.8	3.5	2.3	5.1	0.9	3.6	4.0	5.6	-4.5	3.3	-0.0
Whole body fat-free mass	2.3	13.1	28.0	3.2	4.7	3.5	-0.7	4.0	3.7	3.9	3.6	2.6	5.1	1.0	3.7	4.0	5.3	-4.5	3.3	-0.7
Whole body water mass	2.2	12.8	27.2	3.1	4.5	3.4	-0.7	3.9	3.6	3.8	3.5	2.5	5.0	1.0	3.6	3.9	5.2	-4.4	3.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	8.7	-2.6	-2.2	-2.3	-0.3	-2.6	-2.5	-2.5	-2.2	-2.1	-2.9	-1.3	-1.4	-2.8	-3.0	0.7	-2.2	-0.8
Arm fat-free mass (right)	2.1	10.6	20.2	3.0	4.0	3.2	-0.6	3.7	3.4	3.6	3.3	2.1	4.1	0.8	3.6	3.5	4.5	-4.0	3.2	-0.8
Migraine (self-reported)	2.1	2.6	4.9	-1.6	-0.5	-2.0	0.2	-1.9	-1.9	-2.0	-2.2	-1.6	-0.8	-2.0	-2.2	-1.7	-0.7	-0.8	-2.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	12.0	2.0	2.9	2.4	-1.2	2.5	2.3	2.4	2.5	1.0	2.3	0.2	2.4	2.2	3.5	-0.9	1.4	-0.4
Arm fat-free mass (left)	2.1	10.6	20.3	3.0	4.0	3.2	-0.7	3.7	3.4	3.6	3.2	1.8	4.2	0.8	3.6	3.5	4.5	-4.2	3.4	-0.5
Arm predicted mass (left)	2.1	10.5	21.3	3.0	4.1	3.0	-0.7	3.5	3.2	3.4	3.0	1.9	4.4	0.9	3.4	3.4	4.6	-4.5	3.3	-0.6
Schizophrenia (2018)	2.0	4.2	11.2	2.2	2.9	1.9	-0.2	2.0	1.8	1.8	2.1	1.2	3.4	-0.2	2.0	1.9	2.6	-2.9	2.0	0.1
Worrier / anxious feelings	2.0	3.8	8.3	2.5	0.8	2.5	0.7	2.8	2.9	2.9	2.4	0.3	1.0	-0.3	2.2	2.9	0.5	-0.4	2.2	0.9
Medication: Amlodipine	2.0	2.8	8.3	0.9	1.9	1.1	-0.2	1.4	1.3	1.2	1.5	2.8	2.9	1.4	0.3	1.7	2.0	-2.4	1.8	-1.2
Arm predicted mass (right)	2.0	10.5	20.2	3.1	4.1	3.0	-0.7	3.6	3.2	3.5	3.2	2.0	4.2	0.9	3.6	3.4	4.5	-4.3	3.4	-0.8
Leg fat-free mass (right)	2.0	10.9	21.5	2.8	4.3	3.3	-0.7	3.6	3.4	3.5	3.4	2.9	4.6	1.1	3.3	3.6	4.6	-3.8	2.7	-1.1
Leg predicted mass (right)	2.0	10.9	21.8	2.8	4.3	3.3	-0.7	3.6	3.5	3.5	3.4	2.9	4.7	1.1	3.3	3.6	4.6	-3.8	2.7	-1.1
Severe depression (siblings)	1.9	2.1	4.0	-1.7	-1.1	-1.4	0.7	-1.8	-1.8	-1.8	-1.4	-1.5	-1.9	-0.1	-0.9	-2.0	-1.2	1.6	-1.7	0.1
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	6.6	-2.6	-1.5	-2.2	-0.7	-1.7	-1.6	-1.5	-2.2	-0.1	-0.6	-0.6	-1.4	-1.2	-2.2	-0.3	-1.4	0.0
Heart attack	1.9	2.4	11.8	-1.5	-0.0	-1.6	3.4	-2.1	-1.9	-1.9	-1.4	0.2	0.1	0.0	-1.6	-1.8	-0.5	-1.3	-1.6	-0.3
Mean time to correctly identify matches	1.9	3.6	17.2	1.1	2.1	1.0	-2.1	0.7	0.9	0.9	1.1	1.8	3.0	0.7	1.6	0.7	3.3	-4.2	1.4	-1.1
Ever smoked	1.9	3.3	11.4	1.4	0.5	2.0	-2.0	2.1	2.0	2.0	1.9	1.4	-0.1	3.4	1.9	1.8	0.3	-0.8	2.0	-2.4
Basal metabolic rate	1.9	10.7	22.5	2.8	4.2	3.0	-0.8	3.5	3.2	3.4	3.1	2.3	4.7	1.0	3.3	3.5	4.7	-4.5	2.9	-1.0
Alzheimer’s Disease (in mother)	1.8	2.1	9.1	1.3	1.1	1.0	-0.2	1.3	1.0	1.0	1.1	2.1	3.0	0.8	0.8	1.1	1.1	-2.6	1.1	-1.4
Hand grip strength (left)	1.8	4.7	12.0	1.7	2.4	2.0	0.5	2.8	2.4	2.4	1.7	2.1	2.5	1.0	1.6	2.8	2.1	-3.5	2.6	0.3
Pack years adult smoking proportion	1.8	2.8	5.2	1.7	1.8	1.8	0.1	1.6	1.7	1.6	1.6	2.3	1.4	2.2	1.1	1.7	1.4	-2.0	1.6	-1.4
Hand grip strength (right)	1.8	4.9	14.1	1.3	2.4	1.9	-0.3	2.7	2.3	2.3	1.6	2.7	3.1	1.0	1.4	2.8	2.0	-3.8	2.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	7.1	-2.5	-1.9	-2.2	-0.2	-2.7	-2.5	-2.4	-2.1	-1.9	-2.6	-1.0	-1.2	-2.6	-2.1	1.1	-2.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	12.1	2.6	2.0	2.8	-0.4	3.0	2.9	2.7	2.8	2.7	3.5	-0.4	1.3	3.0	2.6	-2.8	1.6	-0.3
Mother’s age at death	1.8	2.2	4.3	-1.9	-1.5	-1.6	0.2	-1.6	-1.6	-1.7	-1.4	-1.7	-1.2	-2.1	-1.4	-1.7	-1.9	0.1	-1.2	0.8
Age started oral contraceptive pill	1.8	2.3	9.6	1.2	2.6	1.4	0.2	1.1	1.2	1.3	1.4	-0.2	1.5	0.5	2.0	1.1	3.1	0.1	1.7	1.1
Schizophrenia vs Biploar Disorder	1.7	2.3	7.7	-1.2	-0.4	-1.8	-0.1	-1.7	-1.7	-1.6	-1.6	-1.6	-0.1	-2.2	-1.5	-1.3	-0.5	-0.2	-1.9	2.8
Heart attack/myocardial infarction (self-reported)	1.7	2.2	12.5	-1.3	-0.1	-1.4	3.5	-2.0	-1.8	-1.8	-1.2	0.2	0.1	0.2	-1.6	-1.7	-0.6	-1.1	-1.6	-0.4
Pack years of smoking	1.7	2.6	5.2	1.5	2.2	1.6	0.1	1.3	1.4	1.3	1.4	2.3	1.6	2.0	1.1	1.5	1.6	-2.1	1.4	-1.7
Rheumatoid Arthritis	1.6	2.2	5.0	-1.1	-1.6	-1.8	-1.9	-1.4	-1.4	-1.6	-1.7	-0.2	0.1	-1.3	-2.2	-1.1	-1.7	1.4	-1.6	-0.8
Vitamin and mineral supplements	1.6	2.1	5.0	-1.6	-2.2	-1.3	-0.7	-1.7	-1.7	-1.7	-1.1	-2.1	-1.8	-0.0	-0.8	-2.1	-1.8	-1.0	-0.2	0.1
Leg fat-free mass (left)	1.6	8.6	18.3	2.4	3.6	2.8	-1.0	3.2	3.0	3.1	3.0	2.4	4.3	0.7	2.8	3.2	3.9	-3.9	2.5	-1.1
Chronic bronchitis/emphysema (father)	1.6	1.9	8.0	-0.8	-0.2	-0.9	-2.8	-1.0	-1.1	-1.1	-0.6	1.0	0.2	-0.9	-0.5	-1.2	0.1	-2.7	-1.3	-2.7
Leg predicted mass (left)	1.6	8.6	17.7	2.4	3.7	2.8	-0.9	3.2	3.0	3.1	2.9	2.4	4.2	0.7	2.9	3.2	3.9	-3.9	2.4	-1.2
Prospective memory result	1.6	2.0	9.2	-0.5	-0.7	-0.5	-1.5	-0.9	-0.9	-1.0	-0.3	-2.3	1.5	-1.8	-0.7	-1.1	1.9	-1.5	-0.8	3.0
Hearing aid user	1.6	1.8	4.6	0.8	1.4	1.5	-1.2	1.4	1.4	1.5	1.7	0.3	1.1	0.4	2.0	1.2	2.1	-0.4	0.8	-1.7
Townsend deprivation index at recruitment	1.5	2.1	7.2	-2.5	-2.1	-1.4	1.3	-1.2	-1.1	-1.1	-1.3	-0.3	-2.7	1.6	-1.0	-1.0	-1.7	0.5	-1.0	0.8
Hayfever, allergic rhinitis or eczema	1.5	3.2	5.6	-1.6	-2.1	-1.8	-1.8	-1.8	-1.8	-1.8	-2.2	-0.4	-2.0	0.0	-2.0	-1.7	-2.4	1.7	-1.7	-1.6
Medication: Ibuprofen	1.5	1.7	4.1	1.8	-0.1	1.6	-0.6	2.0	1.8	1.9	1.3	0.7	-0.4	1.7	1.7	1.6	-0.7	-0.4	1.4	0.2
Financial situation satisfaction	1.5	1.8	3.9	0.7	1.8	1.2	2.0	1.7	1.6	1.6	1.2	0.3	1.2	0.5	1.6	1.8	0.8	-1.3	1.1	0.9
Eye problems/disorders: Glaucoma	1.5	1.7	5.1	1.7	2.1	1.1	1.3	1.0	1.1	1.1	1.2	1.1	2.0	-0.3	0.8	1.3	2.3	-0.9	0.2	0.3
Basal cell carcinoma (self-reported)	1.5	1.8	6.6	-2.3	-0.6	-1.6	2.6	-1.9	-1.7	-1.6	-1.4	-0.8	-0.3	0.3	-0.4	-1.7	-0.6	-0.4	-1.1	-0.3
Schizophrenia (2014)	1.4	3.0	7.7	1.9	2.3	1.6	-0.5	1.9	1.7	1.7	1.7	0.7	2.8	-1.0	1.4	1.9	1.7	-1.8	2.2	1.0
Fluid intelligence score	1.4	2.9	8.9	-0.8	-1.7	-1.4	0.6	-1.6	-1.7	-1.6	-1.8	-0.9	-2.5	1.7	-0.8	-1.9	-2.9	0.5	-0.8	-3.0
Noisy workplace	1.4	1.7	8.2	0.8	1.6	1.3	0.3	1.3	1.0	0.9	1.2	0.1	2.9	0.3	1.3	0.7	1.9	-1.3	1.6	0.3
Illnesses of father: Heart disease	1.4	2.0	4.9	-1.1	-1.6	-1.8	-0.2	-1.4	-1.6	-1.5	-1.8	-0.8	-0.5	-1.6	-1.6	-1.4	-2.2	-1.4	-1.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.7	-1.2	-1.6	-0.9	-1.5	-1.7	-1.6	-1.8	-0.8	-1.6	0.7	-0.9	-1.2	-2.2	0.2	0.4	-0.5	1.4
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.9	0.6	0.9	1.0	-1.2	1.6	1.6	1.5	1.3	1.8	1.4	0.1	0.3	2.0	1.1	-0.2	1.8	1.3
Average weekly beer plus cider intake	1.4	2.0	5.2	1.0	1.1	1.4	1.8	2.0	2.1	2.0	1.7	2.1	0.3	0.6	1.1	2.3	-0.1	-0.6	0.8	-0.0
Allergy or Eczema	1.3	3.4	6.2	-1.9	-1.9	-2.2	-1.7	-2.2	-2.2	-2.1	-2.5	-0.5	-1.6	-0.8	-2.1	-2.0	-2.1	1.6	-1.6	-1.2
Past tobacco smoking	1.3	2.3	7.5	-1.9	-0.3	-1.8	1.5	-1.6	-1.6	-1.6	-1.8	0.2	0.6	-2.7	-1.9	-1.1	-0.1	0.9	-2.2	0.9
Forced vital capacity (FVC)	1.3	5.2	13.1	2.5	2.2	2.4	0.1	2.7	2.6	2.4	2.5	2.0	3.6	-0.5	1.2	2.7	3.0	-2.5	1.8	-0.2
Depression (self-reported)	1.3	1.5	3.6	-1.9	-0.8	-1.4	0.6	-1.3	-1.4	-1.4	-1.6	-1.2	-1.6	0.7	-1.0	-1.3	-0.6	0.3	-1.8	-0.1
Leg fat percentage (right)	1.3	4.6	9.2	-2.8	-1.5	-3.0	-1.8	-2.3	-2.6	-2.4	-2.9	-0.9	-1.4	-0.1	-2.0	-2.0	-3.0	-1.6	-1.5	-2.2
Eye problems/disorders: None of the above	1.3	1.5	4.7	-1.6	-1.9	-0.7	-1.4	-1.0	-1.0	-1.0	-0.8	-0.6	-2.2	0.1	-1.1	-1.2	-1.6	1.6	-0.3	0.4
Mean Putamen Volume	1.2	1.4	4.1	-1.6	-0.2	-1.2	-0.6	-1.2	-1.0	-1.1	-1.0	0.4	-1.2	-0.2	-1.7	-0.7	-1.4	1.9	-2.0	0.5
Ulcerative Colitis	1.2	1.7	5.0	0.4	1.4	1.4	0.0	1.8	1.9	1.7	1.4	2.0	1.5	-0.3	0.8	2.2	0.5	0.3	0.0	0.1
Smoking status: Previous	1.2	1.9	3.9	2.0	0.7	1.7	-1.2	1.3	1.5	1.5	1.6	0.1	0.2	1.6	1.9	1.0	0.6	-1.6	1.8	-0.6
Mood swings	1.2	2.2	4.5	1.8	0.2	1.8	1.4	2.1	2.0	1.9	1.8	0.8	1.3	1.1	1.0	1.9	1.1	-0.6	2.1	-0.0
Loneliness, isolation	1.2	1.6	4.0	0.7	0.0	1.5	0.9	1.6	1.7	1.9	1.4	0.8	0.2	0.6	2.0	1.6	0.3	0.9	2.0	0.0
Ulcerative Colitis (UC)	1.1	2.1	5.4	0.9	1.4	1.6	-0.5	2.1	2.1	2.0	1.6	1.9	1.5	-0.4	1.3	2.3	0.9	0.2	0.3	0.2
Waist Hip Ratio (WHR)	1.1	5.0	8.2	-2.5	-2.4	-2.6	0.2	-2.7	-2.7	-2.6	-2.4	-1.4	-1.3	-1.4	-1.8	-2.8	-2.9	-1.9	-2.7	-1.5
Average weekly fortified wine intake	1.1	1.2	5.7	1.0	0.3	1.4	-0.4	0.7	0.9	0.7	1.2	-0.8	-0.8	0.7	0.6	0.4	0.2	2.4	1.7	1.8
Pain all over the body in last month	1.1	1.2	2.8	1.3	1.1	1.3	0.5	0.8	1.1	1.1	1.4	1.7	0.5	1.3	1.5	0.9	0.9	-0.3	0.8	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.8	-0.4	-1.6	-1.6	-1.3	-1.2	-1.3	-1.3	-2.0	-1.5	-0.5	0.1	-1.1	-1.2	-1.3	-0.3	0.3	-0.6
Illnesses of siblings: Diabetes	1.1	1.3	7.1	-0.4	0.8	1.0	-0.3	0.2	0.6	0.7	1.0	1.4	0.5	2.7	1.7	0.2	1.7	-1.0	0.4	-1.6
Medication: Atorvastatin	1.1	1.4	5.4	-1.2	-0.4	-1.6	1.2	-0.9	-1.0	-1.0	-1.6	0.5	0.2	-0.3	-1.6	-0.4	-1.2	-2.3	-1.0	-1.0
Alcohol drinker status: Never	1.1	1.3	8.0	-0.5	-0.2	-0.2	1.1	-0.4	-0.3	-0.3	-0.5	-2.8	-0.9	-1.4	0.2	-0.6	-0.1	0.5	0.8	2.8
Risk taking	1.1	1.6	6.9	0.4	0.8	1.2	0.9	1.4	1.4	1.3	1.0	1.1	2.6	0.4	0.5	1.5	1.4	-1.5	1.3	-0.0
Depressed Affect (Nagel 2018)	1.0	2.2	6.9	1.4	-0.4	1.2	1.0	2.3	2.1	2.1	1.1	1.9	1.0	1.0	0.1	2.6	-0.4	1.3	1.6	-0.4
Irritable Bowel Disease (IBD)	1.0	2.3	4.8	1.4	1.6	1.6	0.6	2.1	2.1	2.0	1.7	2.2	2.0	0.0	1.5	2.2	0.7	-0.5	0.6	-0.2
Age at First Birth	1.0	1.4	3.8	-1.3	-0.5	-1.3	-0.9	-1.2	-1.3	-1.4	-1.4	-0.5	-0.7	-1.9	-1.7	-1.2	-1.5	-0.9	-0.6	0.6
Respiratory disease	1.0	2.2	4.4	0.3	1.9	1.6	-0.0	1.5	1.8	1.9	1.7	1.7	1.6	1.0	2.1	1.7	1.4	0.0	1.0	-1.5
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.8	-2.0	-0.7	-1.4	0.6	-1.2	-1.1	-1.0	-1.3	-0.6	-1.2	0.4	-0.3	-0.9	-1.1	0.2	-1.2	-1.7
Diabetes (mother)	1.0	1.3	2.6	0.3	1.6	1.5	-0.3	1.0	1.3	1.3	1.6	1.1	1.0	-0.2	1.3	1.3	1.0	-1.6	1.2	0.5
Maternal smoking around birth	1.0	1.5	4.1	1.1	1.5	0.7	-0.9	1.3	1.1	1.1	0.8	2.0	1.8	0.4	0.3	1.5	1.6	-1.1	0.9	-1.0
Time employed in main current job	1.0	1.1	3.9	1.1	1.3	1.1	1.4	1.2	1.1	0.9	0.9	1.4	2.0	-0.6	0.1	1.0	1.0	-0.5	0.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.6	1.6	0.1	1.4	-0.3	1.5	1.3	1.4	1.1	0.2	-0.6	1.5	1.4	1.0	-0.7	-0.8	1.3	0.4
Birth weight of first child	1.0	1.9	5.2	-2.3	-0.6	-1.3	0.9	-1.9	-1.7	-1.8	-1.5	-1.5	0.3	-1.3	-1.5	-1.9	0.2	-0.8	-1.3	-0.2
Pulse wave peak to peak time	1.0	1.2	8.8	-0.0	2.4	0.5	1.1	0.3	0.3	0.3	0.6	0.1	1.7	0.1	0.6	0.4	3.0	-0.5	0.1	0.3
Illnesses of father: None of the above (group 1)	1.0	1.3	5.9	0.6	-0.3	0.8	2.2	0.7	0.6	0.6	0.8	-1.3	-1.2	0.5	0.6	0.2	0.6	2.4	1.1	1.6
Number of self-reported non-cancer illnesses	1.0	1.7	9.4	-0.6	0.5	-1.3	-1.4	-0.7	-0.7	-0.7	-1.2	1.1	2.2	-0.3	-0.9	-0.2	-0.4	-3.1	-1.5	-2.0
Medication: Paracetamol	1.0	1.5	3.7	0.9	1.1	1.9	-0.7	1.6	1.5	1.5	1.7	0.7	0.9	0.4	1.8	0.9	0.5	-0.9	1.1	-1.2
Leg fat percentage (left)	1.0	3.7	7.6	-2.6	-0.8	-2.8	-1.7	-2.1	-2.4	-2.1	-2.7	-0.4	-1.2	0.2	-1.5	-1.8	-2.4	-1.6	-1.3	-2.3
Breast Cancer	0.9	2.3	8.2	-1.9	-1.6	-1.3	-0.2	-1.6	-1.6	-1.7	-1.5	-0.8	-1.2	-2.9	-1.9	-1.7	-1.0	1.2	-1.2	-0.0
LDL Cholesterol	0.9	1.4	7.1	-0.1	-1.6	-0.1	1.3	0.2	0.2	0.0	-0.5	0.9	-2.3	0.7	-1.0	0.0	-2.7	1.6	-0.9	-1.1
Blood Eosinophil Count	0.9	6.8	27.7	2.2	1.2	2.3	-1.7	2.6	2.3	2.5	2.0	2.5	0.8	5.3	2.7	2.1	0.5	-0.0	3.6	-4.4
Average weekly spirits intake	0.9	1.1	8.7	0.1	0.8	-0.0	-0.1	0.0	-0.0	-0.1	-0.3	0.1	1.5	1.8	-0.0	0.1	0.7	-3.0	-0.5	-1.5
Fed-up feelings	0.9	1.6	4.5	1.3	0.0	0.9	1.4	1.7	1.6	1.6	0.8	1.2	1.4	1.1	0.0	2.1	-0.1	1.3	1.1	1.1
High blood pressure	0.9	2.5	17.4	0.8	1.7	0.5	-1.3	0.7	0.7	0.7	0.6	2.0	2.6	-0.9	0.4	1.0	1.4	-4.2	0.2	-1.9
Multivitamins +/- minerals	0.9	1.1	3.4	0.3	1.5	0.6	1.1	1.0	0.8	0.8	0.4	1.8	1.4	0.5	0.2	1.2	1.3	1.7	-0.1	-1.1
Arm fat percentage (right)	0.9	3.7	6.2	-2.5	-1.2	-2.5	-1.7	-2.4	-2.3	-2.2	-2.4	-0.6	-1.1	0.2	-1.8	-2.0	-2.3	-1.5	-2.0	-2.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.7	0.8	1.3	0.6	0.4	1.3	1.2	1.3	0.9	1.3	1.3	0.8	1.0	1.7	0.7	0.2	0.4	-0.2
Length of working week for main job	0.9	1.0	7.1	1.2	0.1	-0.1	-0.6	-0.0	-0.1	0.1	-0.3	-0.2	-0.5	1.3	1.2	-0.2	-0.9	-1.5	-0.9	-2.7
Loud music exposure frequency	0.9	0.9	4.5	-0.2	0.2	0.9	1.1	0.6	0.9	0.7	0.9	-1.2	-0.7	-1.1	0.2	0.7	0.1	1.9	-0.2	2.1
Neck or shoulder pain in last month	0.9	1.2	5.9	1.0	1.1	0.2	-1.5	0.3	0.3	0.3	0.2	1.7	2.3	-0.7	-0.4	0.5	0.7	-2.4	-0.1	-0.5
Alcohol intake frequency.	0.9	2.0	7.6	-1.4	-1.5	-1.1	0.8	-1.5	-1.4	-1.2	-1.2	-2.4	-2.8	0.1	0.1	-1.7	-1.5	0.5	-0.3	1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.0	0.8	0.8	1.1	-0.3	1.0	1.2	1.1	1.1	0.5	1.5	0.3	1.2	1.1	0.3	-1.7	1.0	-0.2
Arm fat percentage (left)	0.9	3.6	7.2	-2.5	-1.0	-2.4	-1.6	-2.2	-2.2	-2.0	-2.4	-0.3	-1.1	0.3	-1.7	-1.8	-2.3	-1.4	-2.0	-2.7
Commuting to job workplace: Public transport	0.9	1.0	7.5	0.5	-0.1	0.3	1.8	0.8	0.7	0.7	0.0	0.5	-1.4	0.7	0.1	0.9	-1.0	2.7	0.4	0.6
Heart disease (siblings)	0.9	1.1	3.0	-1.7	-0.1	-1.2	1.4	-1.1	-1.1	-1.1	-1.2	0.5	-0.0	-0.4	-1.4	-0.9	-0.3	-1.5	-0.9	-1.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	17.2	0.0	-0.2	-0.7	0.6	-0.8	-0.9	-0.7	-0.9	0.9	-1.5	2.3	-0.3	-0.8	-1.7	0.2	-0.3	-4.2
Prostate Cancer	0.8	1.1	2.1	0.9	1.4	1.4	0.6	1.4	1.4	1.4	1.5	1.3	0.5	0.6	0.9	1.4	0.7	-0.0	0.2	-0.5
BMI	0.8	4.6	11.6	-3.4	-2.0	-2.7	-1.6	-2.5	-2.6	-2.5	-2.6	-1.1	-1.6	-0.3	-2.2	-2.3	-2.3	-1.8	-1.7	-0.8
Supplements: Glucosamine	0.8	1.0	2.9	1.3	1.7	0.7	0.4	1.2	1.1	1.1	0.5	0.6	1.4	-0.8	1.0	1.4	1.2	-0.3	0.1	-0.7
Medication: Atenolol	0.8	1.0	4.8	-0.2	0.7	-0.6	0.4	-0.2	-0.4	-0.4	-0.5	1.2	1.8	1.2	-0.8	-0.1	-0.0	-1.7	-0.8	-2.2
Alcohol usually taken with meals	0.8	1.3	10.4	-0.9	0.1	-0.9	-3.2	-0.9	-0.9	-0.8	-1.1	-0.8	0.6	-1.8	-0.8	-0.6	0.6	-0.0	-1.1	0.2
Weight	0.8	3.8	16.5	0.9	2.8	1.1	-1.3	1.6	1.3	1.5	1.2	1.1	3.1	0.6	1.8	1.6	2.7	-4.1	1.5	-1.6
Hip circumference	0.8	3.4	8.9	1.0	2.7	1.2	-1.2	1.5	1.3	1.6	1.4	0.7	2.7	1.1	2.3	1.5	2.3	-3.0	1.6	-2.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.9	1.8	0.9	1.9	0.3	2.2	2.1	1.9	2.0	2.0	2.6	-0.5	0.6	2.2	1.6	-1.9	1.1	0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	10.1	0.4	1.3	0.3	3.2	0.6	0.4	0.6	0.3	-0.3	-1.0	1.1	1.8	0.3	-0.6	-0.7	1.4	-0.6
Exposure to tobacco smoke at home	0.8	0.9	2.6	-1.1	-0.8	-1.3	1.0	-0.9	-0.7	-0.8	-1.2	0.8	0.2	-1.4	-1.2	-0.2	-1.6	-0.9	-0.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.8	-1.4	-1.4	-0.6	0.7	-0.8	-0.8	-0.7	-0.9	-1.4	-1.4	1.1	-0.4	-1.1	-0.9	1.9	0.1	1.5
Glaucoma (self-reported)	0.8	1.0	2.9	1.2	1.5	0.7	0.4	0.9	0.9	0.9	0.9	1.3	1.7	0.6	0.5	1.1	1.7	-0.4	0.2	-0.2
Medication: Allopurinol	0.8	1.0	3.6	-0.9	-0.8	-1.0	-1.9	-1.4	-1.0	-0.8	-0.6	-0.2	-0.9	-0.1	0.1	-1.0	-1.2	0.5	-1.2	-1.7
Hypertension (Self-reported)	0.8	2.2	17.7	0.5	1.5	0.2	-0.9	0.6	0.5	0.5	0.3	1.9	2.5	-0.4	0.2	0.9	1.3	-4.2	0.2	-1.7
Average weekly red wine intake	0.8	1.2	3.1	-1.3	-0.2	-1.2	-1.8	-1.4	-1.3	-1.3	-1.5	-1.0	-0.2	-0.7	-1.2	-1.0	-0.6	0.3	-1.4	0.1
Long-standing illness, disability or infirmity	0.8	1.2	3.7	-1.4	0.8	-1.3	-0.6	-1.2	-1.2	-1.2	-1.1	-0.3	0.5	-0.4	-0.5	-1.0	0.0	-1.6	-1.9	-1.3
Medication for cholesterol	0.8	1.3	5.9	-0.5	0.5	0.3	2.4	0.0	0.2	0.2	0.3	-1.6	-1.1	0.3	1.2	-0.2	1.2	1.6	1.2	2.0
Ever taken oral contraceptive pill	0.8	0.9	3.3	0.3	0.8	0.9	1.8	0.3	0.6	0.5	0.9	1.4	0.9	1.3	0.3	0.5	1.1	-0.6	1.4	-0.9
Medication: Lisinopril	0.8	1.0	2.3	0.3	-0.7	-1.0	-1.2	-1.4	-1.4	-1.4	-0.9	-0.9	0.8	-1.1	-1.1	-1.5	-0.3	-0.5	-0.5	-0.7
Diastolic blood pressure, automated reading	0.8	2.6	7.6	-1.8	-1.4	-2.1	-2.1	-1.0	-1.2	-1.1	-2.0	1.2	-1.0	-1.2	-1.9	-0.5	-2.8	-2.0	-0.7	-1.9
Crohns Disease (2017)	0.7	1.5	2.2	1.4	1.2	1.3	1.5	1.5	1.4	1.3	1.5	1.4	1.5	0.7	1.2	1.2	0.3	-1.1	0.7	-0.6
Major Depression (MDD)	0.7	0.9	2.5	0.7	-0.1	1.1	0.0	1.3	1.2	1.3	1.3	-0.6	0.3	0.4	1.6	1.0	0.3	0.6	1.2	0.8
Crohns Disease (2012)	0.7	1.1	2.4	0.5	0.8	1.4	1.4	1.4	1.3	1.3	1.6	0.7	1.1	-0.0	1.5	1.0	0.1	-0.0	1.0	-0.3
Taking other prescription medications	0.7	1.0	3.7	-1.2	0.5	-1.4	0.8	-1.0	-1.1	-1.0	-1.3	-0.6	1.0	-1.1	-1.1	-0.5	-0.1	-0.4	-1.9	0.3
High blood pressure (mother)	0.7	1.0	3.9	-0.3	-1.2	-0.6	-0.9	-0.8	-1.0	-1.1	-0.7	-0.3	0.9	-1.4	-1.5	-1.3	-0.6	-2.0	-0.0	-0.4
Number of incorrect matches in round	0.7	1.1	3.1	-1.2	-0.4	-1.3	-1.0	-1.3	-1.4	-1.4	-1.3	-1.8	-0.7	0.8	-0.5	-1.5	-0.2	-0.3	-0.1	0.9
Had other major operations	0.7	0.8	2.5	-0.3	1.3	-1.0	-0.6	-0.3	-0.3	-0.2	-0.9	1.1	1.6	-1.0	-0.5	0.4	-0.1	-1.4	-1.0	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.4	-1.8	-0.3	-0.8	-0.5	-0.6	-0.6	-0.7	-0.8	1.4	0.4	1.1	-1.6	-0.2	0.0	0.1	-1.6	-0.2
Medication: Ramipril	0.7	0.9	6.9	0.3	1.1	0.3	0.1	-0.1	0.2	0.2	0.1	1.6	1.9	-0.1	0.2	0.3	1.1	-2.6	-0.3	-0.2
Hair/balding pattern: Pattern 3	0.7	1.1	5.9	0.4	1.2	0.1	0.2	0.1	-0.1	-0.1	-0.3	1.0	2.3	0.2	0.5	-0.1	1.0	-1.5	0.9	-2.4
Pulse rate	0.7	1.2	9.8	-0.4	-0.3	-0.5	-1.5	-1.0	-0.8	-0.8	-0.3	-0.1	1.3	-1.7	-0.5	-0.9	0.3	-3.1	-0.1	-0.2
Pulse wave reflection index	0.7	0.9	2.6	-0.1	-1.5	-0.4	1.2	-0.3	-0.4	-0.5	-0.7	-0.6	-1.6	1.4	-0.6	-0.6	-1.6	0.7	-0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	4.3	0.8	0.2	0.6	-0.5	0.3	0.5	0.7	0.6	-1.7	-0.8	-2.1	1.9	0.1	-0.9	0.3	0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.4	-0.6	-1.3	-0.9	-0.9	-0.6	-1.0	-1.1	-1.0	0.2	-0.7	-0.1	-1.5	-1.0	-1.3	-0.7	-0.7	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	4.6	0.3	-1.2	-0.1	-0.3	0.3	0.2	-0.0	-0.2	-0.0	-0.7	-1.6	-1.1	0.2	-2.1	1.8	-0.1	0.8
Qualifications: nursing, teaching	0.7	1.1	3.5	-1.9	-1.4	-0.9	0.2	-1.1	-1.1	-1.1	-1.0	-1.1	-0.4	1.2	-1.1	-1.2	-1.2	0.4	-0.2	-0.2
Asthma (self-reported)	0.7	1.4	3.2	-0.2	1.6	1.1	-0.9	1.1	1.3	1.5	1.3	1.7	1.3	-0.3	1.8	1.4	1.1	-0.4	0.3	-1.2
Medication: Blood pressure	0.7	1.3	7.8	0.1	0.2	-0.4	-1.5	-0.3	-0.3	-0.3	-0.5	1.5	1.3	-0.6	-0.5	-0.1	-0.3	-2.8	-1.1	-2.4
Medication: Bendroflumethiazide	0.7	1.1	8.9	0.3	-0.2	-0.6	-1.0	-0.5	-0.8	-0.8	-0.8	-0.7	0.7	-1.8	-0.9	-0.8	0.4	-3.0	-0.5	-0.0
Number of operations (self-reported)	0.7	1.1	3.8	-1.5	0.0	-1.3	-2.0	-1.1	-1.1	-0.9	-1.4	-0.2	-0.3	0.2	-0.3	-0.7	-0.9	-0.4	-0.9	-1.6
Vascular/heart problems diagnosed by doctor	0.7	2.0	17.5	0.1	-1.3	0.2	1.1	0.0	0.1	0.0	0.1	-1.6	-2.3	0.8	0.1	-0.2	-1.1	4.2	0.2	1.7
Alzheimer’s Disease (in father)	0.6	0.6	1.7	0.9	0.4	0.9	-0.5	0.5	0.7	0.7	1.1	0.9	0.9	-0.3	0.7	0.4	0.6	0.1	1.3	-1.3
HDL Cholesterol	0.6	0.9	2.8	-0.8	-0.3	-0.9	-1.4	-1.1	-1.1	-1.2	-0.2	-0.5	0.8	-1.1	-1.3	-1.0	0.5	0.2	-1.7	0.7
Neuroticism (2016)	0.6	0.8	2.5	-0.2	-0.9	0.3	-0.3	1.0	1.1	1.1	-0.0	-0.2	-0.7	-0.9	0.5	1.3	-1.1	1.6	1.1	1.2
Primary Biliary Cirrhosis	0.6	0.8	4.3	0.5	0.1	0.9	-0.7	0.3	0.4	0.4	0.9	-1.4	0.5	-0.7	0.8	-0.0	1.5	0.8	0.7	2.1
Triglycerides	0.6	1.0	2.8	-1.0	-1.1	-0.9	1.1	-0.4	-0.4	-0.5	-1.6	1.1	-1.7	0.1	-1.1	-0.3	-1.7	-0.3	-0.4	-0.8
Sensitivity / hurt feelings	0.6	1.0	2.5	1.3	-0.5	1.0	-0.5	1.4	1.4	1.3	0.9	0.1	-0.7	1.1	0.5	1.3	-0.5	0.0	1.6	0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.5	-0.0	0.2	0.8	1.3	1.2	1.1	1.2	0.4	0.2	0.4	0.8	0.6	1.4	0.8	0.4	1.1	1.6
Relative age of first facial hair	0.6	1.3	4.0	0.4	1.6	0.5	-1.3	0.9	0.7	0.8	0.5	1.4	1.1	1.4	0.7	1.1	2.0	1.0	0.6	-1.6
Angina	0.6	0.8	5.9	-1.4	-0.1	-0.7	2.4	-0.9	-0.9	-0.9	-0.7	-0.2	0.5	0.3	-1.0	-1.0	-0.0	-0.7	0.0	0.2
Serious illness, injury or assault to yourself	0.6	0.7	2.4	-1.1	-0.6	-0.5	-1.6	-1.3	-0.8	-0.8	-0.4	-0.8	-0.8	-0.6	-0.3	-1.0	-0.5	0.8	-0.4	0.8
Hair/balding pattern: Pattern 2	0.6	0.7	2.5	-0.3	-1.2	0.8	1.6	0.2	0.5	0.3	0.9	-1.1	-0.4	0.3	0.1	-0.1	-0.6	1.3	1.2	1.3
Alcohol intake versus 10 years previously	0.6	0.9	2.9	0.1	0.7	1.1	1.2	0.6	1.0	1.2	1.0	-0.7	0.2	0.6	1.7	0.8	1.5	-0.4	1.1	0.5
Falls in the last year	0.6	0.8	2.3	1.3	0.7	0.7	1.5	1.2	0.9	0.7	0.7	0.1	0.5	0.9	0.4	0.9	0.7	-1.3	0.7	0.3
Happiness	0.6	0.7	3.7	0.9	0.4	0.5	1.1	1.3	0.8	0.9	0.2	0.2	-0.1	1.9	0.6	1.0	0.1	-0.5	0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.4	6.9	-0.5	-0.4	-1.2	-1.3	-0.9	-0.8	-0.9	-1.5	1.1	-0.8	1.3	-1.5	-0.5	-1.5	0.6	-0.9	-2.6
Medication: Cholesterol lowering	0.6	0.9	2.9	-0.6	-0.4	-0.9	0.9	-1.5	-1.4	-1.4	-0.7	-0.6	-0.7	0.0	-0.8	-1.7	-0.4	-0.6	-1.0	-0.6
Lung cancer (father)	0.6	0.7	4.2	-1.0	0.6	-0.4	2.0	-0.6	-0.4	-0.4	-0.3	-0.2	0.3	-1.0	-0.4	-0.3	0.6	0.7	-1.3	1.4
Illnesses of mother	0.6	0.7	3.8	0.7	-2.0	0.4	1.6	0.3	0.6	0.4	0.5	0.1	-1.0	0.1	-0.7	0.3	-1.4	0.4	0.2	0.0
Pulse wave Arterial Stiffness index	0.6	0.7	5.2	0.6	-2.0	-0.1	-1.1	0.1	0.1	0.1	-0.1	-0.2	-1.3	-0.1	-0.2	-0.0	-2.3	0.3	0.3	-0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.8	0.4	0.3	1.2	-1.3	1.0	1.1	1.0	1.1	0.9	1.2	0.0	0.5	1.1	0.2	-0.3	0.4	-0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	5.1	0.6	-0.7	0.8	0.4	1.4	1.3	1.3	0.7	0.2	-0.5	0.2	0.6	1.4	-0.8	2.2	0.7	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	5.0	-1.0	0.9	-0.2	0.4	0.0	0.1	0.2	-0.4	0.1	-1.2	1.5	0.6	0.4	0.6	2.2	-0.1	0.8
Body fat percentage	0.6	2.2	5.6	-1.7	-0.5	-1.9	-2.1	-1.5	-1.7	-1.5	-1.9	0.1	-0.1	-0.0	-1.3	-1.3	-1.6	-1.9	-0.9	-2.4
Medication: Blood pressure	0.6	1.1	9.5	0.6	1.2	0.2	-1.1	-0.4	-0.2	-0.2	0.4	0.1	1.6	-0.4	0.3	-0.4	1.4	-3.1	0.3	-0.7
Angina (self-reported)	0.6	0.8	5.9	-1.4	-0.1	-0.7	2.4	-0.8	-0.8	-0.8	-0.7	-0.1	0.6	0.3	-0.9	-0.8	-0.2	-0.7	0.0	0.3
Medication: Seretide 50 evohaler	0.6	0.7	1.8	0.5	1.3	0.9	-0.8	0.8	0.7	0.7	0.8	0.7	1.0	-0.2	0.7	0.6	0.5	-0.6	1.3	-1.2
Had major operations	0.6	0.8	4.8	-1.0	0.5	0.2	-0.6	-0.7	-0.3	-0.3	-0.0	0.1	0.4	0.4	0.5	-0.6	0.1	-2.2	-0.4	-2.2
Leg pain on walking	0.6	0.8	3.1	0.8	0.4	0.9	1.1	0.6	0.8	0.9	0.8	-0.0	0.3	-0.1	1.3	0.7	0.7	-1.0	1.1	1.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.7	0.8	-1.1	0.3	-1.6	0.8	0.6	0.5	0.1	1.1	-1.5	-0.9	-0.3	0.7	-1.5	0.1	-0.4	0.1
Supplements: Calcium	0.6	0.6	3.8	0.8	0.5	0.3	1.9	0.5	0.6	0.7	0.2	0.3	-0.2	1.6	0.8	0.7	-0.3	-0.5	-0.6	0.5
Neuroticism (Nagel 2018)	0.5	1.1	4.3	0.7	-0.8	0.4	0.5	1.6	1.5	1.4	0.5	1.3	0.9	0.5	-0.4	2.1	-0.7	0.9	1.5	0.0
HbA1C	0.5	0.5	2.3	-1.0	-1.5	-0.4	-0.3	-0.7	-0.5	-0.6	-0.4	-1.0	-0.8	0.6	-0.0	-0.8	-1.3	-0.2	0.3	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	0.5	0.4	1.3	0.6	1.1	1.1	0.9	0.9	1.3	0.3	-0.5	0.3	0.9	0.3	-0.6	-0.1	-0.2
Systolic Blood Pressure	0.5	2.7	20.1	0.8	1.9	-0.2	-0.9	0.8	0.5	0.6	-0.1	2.4	2.7	-1.7	-0.5	1.3	1.4	-4.5	-0.2	-0.8
Hypothyroidism (self reported)	0.5	1.2	3.2	-1.3	0.6	-1.4	-1.4	-1.0	-1.2	-1.3	-1.4	-1.0	1.1	-1.4	-1.8	-0.7	-0.2	-0.4	-0.8	0.6
Chronotype (morning person)	0.5	1.2	8.4	0.9	-0.4	0.2	0.4	0.3	0.1	0.3	0.1	-2.4	-0.4	-0.6	1.3	-0.0	-0.3	-1.4	0.6	2.9
Number of treatments/medications taken	0.5	0.8	3.9	0.7	1.4	-0.0	-0.2	0.6	0.4	0.4	-0.1	1.2	1.8	1.1	0.1	0.8	-0.0	-2.0	0.2	-0.9
Ever had hysterectomy (womb removed)	0.5	0.6	3.2	-1.8	-0.2	-0.9	-1.4	0.4	-0.1	0.1	-1.0	1.4	-0.3	0.1	-0.7	0.7	-0.3	0.5	-0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.9	0.7	-0.5	0.3	-0.6	0.4	0.4	0.2	0.2	-0.8	0.8	-1.7	-0.3	0.2	-0.4	-1.7	1.1	0.4
Medication for hormone replacement therapy	0.5	0.6	4.2	0.1	-0.4	0.2	-1.4	0.5	0.4	0.5	0.4	1.2	-0.4	0.4	0.4	0.6	-0.6	-0.3	-0.2	-2.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.9	-0.8	-0.4	-0.2	-0.6	-1.1	-0.9	-0.8	-0.2	-1.1	-0.7	-1.0	0.3	-1.4	-0.3	-0.3	-0.6	-0.8
Body mass index (BMI)	0.5	2.1	5.0	-2.1	-0.3	-1.8	-1.5	-1.4	-1.6	-1.4	-1.7	-0.4	-0.9	0.2	-0.8	-1.3	-1.8	-1.7	-1.4	-2.2
Waist circumference	0.5	1.8	11.8	-1.3	0.3	-1.3	-1.8	-1.0	-1.3	-1.1	-1.1	-0.4	0.9	-0.3	-0.2	-1.0	-0.2	-3.4	-0.7	-2.1
Illnesses of siblings	0.5	0.6	2.8	0.8	0.0	0.6	0.4	1.0	0.9	0.8	0.6	-0.0	1.0	-1.0	-0.4	1.2	-0.2	0.3	0.7	1.7
Neuroticism score	0.5	1.0	3.4	1.0	-0.4	0.9	0.7	1.6	1.6	1.5	0.9	0.7	0.6	0.1	0.0	1.9	-0.5	0.1	1.2	0.8
Medication: Lansoprazole	0.5	0.6	3.8	-0.7	-0.2	-0.5	0.3	-0.3	-0.6	-0.5	-0.4	-0.7	-0.6	-1.9	-0.3	-0.7	-1.1	-0.7	-0.8	0.8
Peak expiratory flow (PEF)	0.5	1.2	4.0	2.0	0.4	1.6	-1.8	1.1	1.2	1.1	1.6	0.8	0.8	0.2	0.7	0.9	0.4	-0.1	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	0.8	0.1	1.3	-0.5	0.3	0.5	0.5	1.5	-0.5	0.6	0.4	1.5	-0.2	0.4	-0.9	1.3	-0.0
Headache pain in last month	0.5	0.8	3.6	-0.2	0.2	0.7	0.9	0.6	0.6	0.6	0.7	0.0	1.1	0.4	0.0	0.6	0.8	-1.9	1.3	1.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.6	-0.9	0.1	-1.4	-0.3	-0.7	-0.9	-1.0	-1.3	-0.9	1.2	-1.6	-1.4	-0.4	-0.6	-0.2	-1.3	0.5
Shortness of breath walking on level ground	0.5	0.6	3.0	0.3	0.2	0.1	-0.1	0.9	0.9	0.9	-0.0	1.7	0.9	0.4	0.3	1.4	-0.7	-1.2	-0.2	-0.1
Medication: Omeprazole	0.5	0.6	1.4	1.2	-0.4	0.6	-0.5	1.2	0.9	0.9	0.5	0.8	-1.1	0.5	0.1	1.1	-0.6	0.3	0.3	0.8
Suffer from ‘nerves’	0.5	0.8	2.1	0.6	1.5	0.6	1.3	0.7	0.8	0.8	0.7	1.0	1.4	0.0	0.6	1.0	1.0	-0.6	0.7	0.3
Age at last live birth	0.5	0.8	3.3	0.5	0.5	0.8	-0.8	0.6	0.6	0.5	0.7	0.6	1.6	1.2	-0.0	0.5	1.8	-1.2	0.4	-0.5
Supplements: Vitamin C	0.5	0.6	1.4	1.0	0.8	0.8	0.9	0.7	0.9	1.0	0.8	0.2	0.5	0.2	0.6	1.1	0.5	1.0	0.2	1.2
Knee pain experienced in last month	0.5	0.8	5.1	1.3	-0.4	0.9	2.3	0.6	0.4	0.5	0.7	-1.1	-0.1	1.0	1.1	-0.1	-0.2	-0.6	1.1	0.1
Osteoporosis (self-reported)	0.5	0.6	1.5	0.3	-0.2	1.1	0.1	0.7	1.0	1.0	1.2	0.4	-0.5	-0.1	0.9	0.7	0.5	1.2	0.9	0.4
Average weekly champagne plus white wine intake	0.5	0.7	2.5	-0.8	-0.9	-0.8	-1.5	-0.6	-0.8	-0.8	-0.8	-1.6	-0.9	-0.7	-0.3	-0.8	-0.2	1.0	-0.6	0.3
Miserableness	0.5	0.9	6.0	0.2	-2.4	-0.3	0.7	0.1	-0.1	-0.2	-0.2	-0.7	-1.2	0.6	-1.0	-0.2	-1.8	1.3	-0.3	-1.0
Ever depressed for a whole week	0.5	0.6	3.9	-0.2	0.7	0.2	-0.1	-0.1	-0.0	-0.0	0.1	1.4	0.0	2.0	-0.2	0.1	0.3	-0.6	-1.6	-0.9
Depression (Nagel 2018)	0.4	0.6	3.3	-0.9	-0.7	-0.0	0.8	0.9	0.6	0.6	-0.2	0.7	0.3	-0.1	-0.8	1.2	-0.0	0.7	0.5	1.8
Lupus	0.4	0.6	1.5	0.5	0.7	1.0	0.2	0.9	1.0	1.1	0.8	0.8	1.2	-0.5	0.9	1.0	0.5	0.5	0.7	-0.2
Smoking Status	0.4	1.0	5.2	1.2	0.5	1.0	0.2	1.0	0.8	0.9	1.1	-0.6	-0.3	2.3	1.1	0.5	0.7	-0.7	1.6	-0.8
Neuroticism	0.4	1.0	4.3	0.5	-0.4	0.6	1.0	1.6	1.6	1.5	0.7	1.4	0.6	0.2	-0.1	2.1	-0.7	0.3	0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.8	-0.3	1.7	-0.1	0.2	0.3	0.5	0.6	0.0	-0.2	1.3	-0.1	0.9	0.9	0.6	0.6	-0.8	0.6
Medication: Co-codamol	0.4	0.4	2.0	-0.4	1.4	0.2	0.4	-0.4	-0.0	0.1	0.0	-0.8	0.1	0.4	0.9	0.0	1.2	-0.5	0.1	1.3
Medication: Metformin	0.4	0.5	2.4	0.9	0.7	0.6	-0.5	0.5	0.4	0.4	0.5	-0.3	1.0	-0.1	0.8	0.2	1.3	-1.5	0.5	0.4
Trunk fat percentage	0.4	1.7	7.1	-1.2	-0.0	-1.4	-2.3	-1.1	-1.2	-1.1	-1.4	0.4	0.6	-0.0	-0.9	-0.8	-0.8	-2.0	-0.7	-2.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.5	-0.9	-0.7	-0.5	-1.6	-0.6	-0.4	-0.3	-0.4	-0.3	-0.6	0.5	0.0	-0.3	-0.7	-0.3	0.5	-0.9
Stomach or abdominal pain in last month	0.4	0.6	2.7	-1.3	-0.6	-0.3	1.6	-0.1	-0.4	-0.3	-0.5	-0.1	-1.1	0.7	-0.0	-0.6	-1.0	0.9	-0.3	0.6
Medication: Levothyroxine sodium	0.4	0.6	2.4	-0.1	0.8	-0.6	-0.8	-0.4	-0.4	-0.5	-0.6	-0.4	1.5	-1.5	-0.8	-0.1	0.4	-0.9	-1.2	0.2
Trunk fat mass	0.4	1.5	9.9	-0.3	1.2	-0.5	-2.1	-0.1	-0.3	-0.1	-0.4	0.9	1.8	0.2	0.1	0.2	0.7	-3.1	0.2	-2.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	3.8	-2.0	-0.7	-1.1	0.2	-0.7	-0.7	-0.6	-1.0	-0.9	0.1	-0.7	-0.8	-0.3	-1.1	0.1	-0.4	0.4
Mouth/teeth dental problems	0.4	0.5	2.4	0.7	-1.6	0.3	-0.9	0.3	0.4	0.2	0.3	1.0	1.3	-0.6	-1.3	0.4	0.2	0.1	0.2	0.0
Allergy	0.4	0.9	4.3	1.3	1.2	0.3	1.0	0.4	0.3	0.3	0.4	-0.5	0.9	0.3	0.6	0.4	1.5	-1.1	0.7	2.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.0	0.0	-1.4	-0.6	-0.3	-0.5	-0.5	-0.4	-0.8	-1.0	-1.2	1.1	-0.3	-0.6	-0.5	1.0	0.2	-0.2
Asthma	0.4	0.8	2.3	-0.5	1.2	0.8	-0.6	0.7	0.9	1.1	0.9	1.1	0.8	-0.6	1.5	0.9	0.7	0.2	-0.0	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	4.8	0.2	0.3	0.7	-2.2	0.7	0.7	0.5	0.4	0.9	0.1	-0.6	-0.4	0.6	-1.0	1.4	0.3	-0.7
Blood clot in the leg (DVT)	0.4	0.5	2.1	-0.7	-0.6	0.1	0.0	0.4	0.5	0.4	0.5	0.6	1.0	-1.2	-0.3	0.6	-0.5	-1.1	0.7	1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	-0.8	0.1	-0.7	-1.4	-0.4	-0.5	-0.3	-0.6	-0.6	-1.2	0.2	0.3	-0.4	-1.4	1.0	-0.4	-0.6
Birth weight	0.4	0.8	3.1	-0.9	1.7	-0.5	1.3	-0.1	-0.4	-0.4	-0.5	-0.5	0.2	-0.9	-0.3	-0.2	1.8	1.0	-1.5	0.2
Worry too long after embarrassment	0.4	0.7	2.1	0.5	-1.5	0.3	-1.2	0.8	0.8	0.6	0.4	0.7	-0.5	1.3	-0.7	0.7	-1.3	0.2	1.3	0.4
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	0.5	1.2	0.5	-1.1	0.8	0.6	0.8	0.6	0.3	0.1	-0.7	1.1	0.7	-0.4	-1.4	0.7	-1.0
Age at first live birth	0.4	0.7	3.1	0.2	1.0	-0.3	-1.6	-0.2	-0.1	-0.0	-0.4	-0.1	1.1	-0.4	0.0	0.2	1.8	-1.3	0.5	-1.0
Emphysema/chronic bronchitis	0.4	0.4	2.2	0.3	0.8	0.9	-1.5	0.5	0.6	0.5	0.9	0.3	0.9	0.5	0.1	0.4	0.8	0.2	0.2	-0.5
Heart disease (mother)	0.4	0.4	2.2	-0.6	1.5	-0.1	0.1	-0.3	-0.4	-0.2	-0.2	0.1	0.7	0.9	1.4	-0.5	1.0	-0.3	0.2	-0.3
Number of full sisters	0.4	0.5	1.4	0.2	0.6	0.6	1.2	1.0	0.7	0.8	0.6	0.1	0.2	-1.1	1.0	0.8	0.6	-0.5	0.2	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	-0.2	-0.5	-0.8	0.9	-0.9	-0.8	-0.7	-0.9	-0.9	-0.3	-0.8	-0.8	-0.6	-0.1	0.2	-1.2	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	4.0	-0.2	1.2	-0.1	-1.5	0.0	-0.1	-0.0	0.2	-0.3	-0.7	-0.3	0.5	0.0	0.5	2.0	-0.1	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.7	-0.7	-0.6	-0.7	-1.3	-0.7	-0.5	-0.6	-0.9	0.1	-0.1	-0.2	-1.1	-0.2	-0.5	-0.3	-1.3	-0.9
Fractured/broken bones in last 5 years	0.4	0.5	1.8	0.2	0.4	0.3	-0.7	1.0	0.8	0.8	0.6	0.7	1.0	0.1	-0.5	1.3	0.1	-1.0	0.4	0.4
Unable to work because of sickness or disability	0.4	0.5	2.2	-0.8	-0.7	0.1	-0.7	-0.5	-0.2	-0.1	0.3	0.4	0.3	1.5	0.6	-0.5	1.0	-0.8	-0.2	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.2	-0.5	-0.5	0.1	-0.3	0.4	0.5	0.4	0.5	0.5	1.0	-1.1	-0.3	0.6	-0.1	-0.9	0.7	1.5
Alcohol drinker status: Previous	0.4	0.4	2.2	-1.0	-0.2	-0.5	-1.5	-0.3	-0.3	-0.0	-0.6	-0.8	-0.9	-0.1	0.4	-0.1	-0.8	-0.7	-0.3	0.3
Coronary Artery Disease (CAD)	0.3	0.4	2.2	-0.1	0.1	0.0	0.2	-0.4	0.0	0.0	-1.0	0.5	-0.5	0.9	0.1	-0.1	-0.9	-1.5	0.2	-0.9
Blood White Count	0.3	2.6	18.8	-0.1	-1.6	-0.4	-1.0	-0.3	-0.3	-0.2	-0.3	-0.3	-2.6	4.3	0.2	-0.5	-1.7	3.0	0.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.5	0.4	0.0	-0.6	-0.2	-0.6	-0.7	-0.6	-0.4	-1.6	0.2	-0.1	0.0	-0.8	0.7	-1.9	0.2	-0.5
Lung FEV1/FVC ratio	0.3	1.7	9.1	-1.1	-3.0	-0.7	0.8	-0.6	-0.6	-0.8	-0.6	-0.0	-1.5	1.9	-1.6	-0.7	-2.3	1.1	-0.1	0.7
Systolic blood pressure, automated reading	0.3	1.0	4.0	-0.5	1.0	-0.8	-1.3	0.1	-0.2	-0.1	-0.7	1.5	1.5	-1.7	-0.7	0.4	0.6	-2.0	0.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.1	-0.7	-0.2	0.6	0.7	0.4	0.4	-0.4	0.7	0.5	0.5	-1.0	1.0	-0.4	0.2	-0.2	1.1
Relative age voice broke	0.3	0.4	1.2	-0.6	0.6	-0.6	-0.8	-0.3	-0.5	-0.3	-0.7	-0.8	-1.1	0.4	0.7	-0.4	-0.3	-0.7	-0.6	-1.0
Financial difficulties in last 2 years	0.3	0.4	1.5	0.0	-0.5	0.3	1.2	0.2	0.2	0.1	0.2	0.1	-0.9	0.9	0.1	0.1	-0.5	1.2	0.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	0.0	0.2	0.3	0.9	0.8	0.5	0.4	0.4	0.8	1.4	0.3	-0.5	0.7	1.4	0.7	0.1	0.8
Arm fat mass (right)	0.3	1.2	7.5	-1.1	0.5	-0.9	-1.8	-0.6	-0.7	-0.5	-0.9	0.1	0.5	0.2	-0.2	-0.4	-0.3	-2.7	-0.7	-2.0
Breastfed as a baby	0.3	0.3	1.9	0.4	0.8	0.4	-0.7	0.7	0.5	0.5	0.1	-0.4	0.2	-0.2	0.6	0.6	0.2	-1.4	0.0	0.5
Hair/balding pattern: Pattern 4	0.3	0.7	2.5	0.5	-0.2	0.9	-0.1	1.0	1.0	1.0	1.1	0.4	-0.2	1.6	1.0	0.7	-0.1	-0.7	1.2	-0.1
Medication: Paracetamol	0.3	0.5	1.8	0.2	0.8	1.1	-0.3	0.8	0.8	0.9	0.8	0.0	0.4	0.6	1.3	0.4	-0.1	-0.1	0.8	-1.2
Gout (self-reported)	0.3	0.4	2.3	-0.3	-0.2	-0.6	-0.6	-0.5	-0.2	0.0	-0.3	0.2	-0.8	0.3	0.7	0.0	-1.0	0.5	-0.9	-1.5
Exposure to tobacco smoke outside home	0.3	0.4	1.8	-0.9	0.2	-0.5	1.3	-0.1	-0.1	-0.2	-0.5	0.1	1.3	0.0	-0.8	0.3	0.0	-0.3	-0.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	2.0	-0.1	-0.1	0.1	1.1	-0.2	-0.2	-0.2	0.1	-0.3	-1.3	1.4	-0.1	-0.4	0.0	0.5	0.6	1.1
Qualifications: College or University degree	0.3	1.0	4.9	-1.0	1.1	-0.5	-2.2	-0.4	-0.3	-0.2	-0.8	1.0	-0.8	1.9	-0.4	0.3	0.4	0.9	-1.0	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	0.2	0.7	0.5	0.7	0.3	0.2	0.1	0.3	0.2	0.7	0.3	0.3	0.0	1.0	-0.7	0.8	1.1
Whole body fat mass	0.3	1.3	9.6	-0.6	1.0	-0.6	-1.8	-0.1	-0.3	-0.1	-0.6	0.7	1.3	0.3	0.1	0.1	0.3	-3.1	0.2	-2.0
Leg fat mass (right)	0.3	1.3	8.7	-1.2	0.3	-1.2	-1.5	-0.6	-0.8	-0.6	-1.1	0.3	0.3	0.2	-0.3	-0.4	-0.8	-3.0	-0.1	-2.0
Pulse rate, automated reading	0.3	1.0	7.5	-0.4	0.9	-0.3	-1.1	-0.5	-0.3	-0.3	-0.3	0.9	1.7	0.0	0.0	-0.1	1.5	-2.7	0.3	-0.8
Overall health rating	0.3	0.7	8.2	-0.1	0.0	0.0	1.0	0.2	0.2	0.1	0.2	0.9	1.4	0.1	-0.3	0.3	0.3	-2.9	0.3	0.1
Chest pain or discomfort	0.3	0.4	2.1	-0.1	-1.1	0.4	-0.0	0.3	0.3	0.2	0.3	0.8	-0.5	0.4	-0.4	-0.0	-1.4	-0.5	0.4	-1.4
Medication: Aspirin	0.3	0.4	1.7	0.5	0.5	0.3	1.3	-0.4	-0.1	-0.2	0.3	0.3	0.9	1.0	-0.1	-0.3	0.3	-0.9	0.7	-0.3
Ever had bowel cancer screening	0.3	0.3	1.0	0.9	0.5	0.4	0.2	0.7	0.5	0.5	0.4	0.9	1.0	0.1	0.7	0.5	0.3	-0.6	0.2	0.3
Commuting to job workplace: Walk	0.3	0.3	2.2	0.2	0.2	0.1	-0.8	0.1	0.2	0.2	0.3	-0.0	0.0	0.1	-0.3	0.3	0.6	1.4	-0.2	1.5
Eye problems/disorders: Cataract	0.3	0.4	2.1	0.6	0.9	-0.2	-0.2	-0.1	-0.1	-0.1	-0.0	0.2	1.4	-1.0	0.1	0.1	0.3	-1.1	-0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.0	-1.4	0.9	-1.1	-0.7	-0.6	-0.7	-0.6	-1.1	-0.4	0.1	0.8	-0.4	-0.2	-0.0	0.0	-0.9	0.2
Back pain experienced in last month	0.3	0.4	2.4	-0.3	-0.5	-0.2	-0.2	-0.3	-0.4	-0.6	-0.1	-0.6	0.5	-1.0	-1.0	-0.5	-0.2	-1.6	-0.1	0.9
Mineral and other dietary supplements	0.3	0.4	2.1	-0.3	-1.0	-0.4	-0.4	-0.6	-0.5	-0.5	-0.3	-0.2	-1.1	-0.2	-0.4	-0.6	-1.4	-0.8	-0.2	-0.2
Medication: Aspirin	0.3	0.4	2.3	0.7	0.5	0.6	1.5	-0.3	0.1	-0.0	0.6	0.5	0.9	0.8	-0.0	-0.3	0.5	-0.9	0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	4.1	0.2	0.3	0.1	-0.5	0.4	0.5	0.4	0.3	2.0	1.0	-0.0	-0.6	0.9	-0.3	-1.0	-0.7	-0.9
Arm fat mass (left)	0.3	1.2	6.4	-1.3	0.4	-1.1	-1.6	-0.7	-0.8	-0.6	-1.0	0.0	0.3	0.2	-0.2	-0.5	-0.5	-2.5	-0.8	-2.1
Guilty feelings	0.3	0.5	1.8	0.3	-0.7	-0.2	1.3	0.7	0.5	0.6	0.2	-0.1	0.6	-0.5	-0.3	0.9	-0.2	0.4	1.2	1.0
Irritability	0.3	0.6	3.0	-0.8	-0.1	-0.5	1.1	-0.3	-0.4	-0.4	-0.7	0.2	1.0	1.1	-0.5	-0.3	-0.8	-1.7	0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.5	1.1	0.3	0.6	-0.7	0.2	0.2	0.1	0.4	0.2	0.0	-0.1	0.1	-0.0	0.8	-0.8	0.4	1.2
Myopia	0.3	0.5	2.3	-0.3	-0.8	0.5	-1.5	-0.0	0.0	-0.1	0.5	1.0	-0.8	-0.4	-0.8	-0.2	-0.0	1.1	0.2	0.7
Leg fat mass (left)	0.3	1.4	9.4	-1.1	0.7	-1.1	-1.6	-0.6	-0.8	-0.5	-1.1	0.5	0.5	0.2	0.0	-0.3	-0.5	-3.1	-0.1	-2.2
Worry (Nagel 2018)	0.2	0.5	1.8	0.6	0.2	0.3	-0.1	1.0	0.9	0.9	0.4	0.8	0.8	-1.0	-0.2	1.4	-0.1	0.0	0.3	0.2
Ovarian Cancer	0.2	0.3	2.7	0.6	0.4	0.3	0.5	0.2	0.3	0.3	0.2	0.7	0.0	-0.8	0.2	0.2	-0.1	-0.1	-0.3	1.7
Cardiovascular Disease	0.2	0.6	6.6	-0.3	-0.4	-0.3	-0.5	-0.1	-0.2	-0.2	-0.2	0.5	1.0	-0.1	-1.0	0.0	-0.2	-2.6	0.1	0.1
Impedance of leg (right)	0.2	0.8	3.6	0.0	-1.9	-0.8	-0.1	-0.6	-0.7	-0.7	-0.8	-1.3	-0.7	-1.0	-1.0	-0.6	-1.1	0.6	0.3	1.1
Nervous feelings	0.2	0.4	1.6	-0.8	-0.8	-0.3	0.2	-0.0	-0.1	-0.1	-0.4	-0.6	-0.5	-1.2	-0.6	-0.0	-0.9	0.4	-0.5	1.1
Qualifications: None of the above	0.2	0.5	1.7	0.4	-0.1	0.4	0.6	0.5	0.5	0.6	0.4	0.2	0.6	0.9	0.9	0.4	0.9	-1.1	1.3	1.1
Diabetes (self-reported)	0.2	0.3	1.8	-0.1	0.2	-0.2	0.6	-0.4	-0.3	-0.3	-0.1	-0.6	0.4	-0.4	-0.2	-0.4	0.8	-1.3	0.4	0.3
Medication: Simvastatin	0.2	0.4	1.2	0.6	-1.1	0.2	-1.0	-0.4	-0.4	-0.5	0.3	-0.8	-0.0	-0.6	-0.3	-0.9	-0.2	0.4	0.2	0.8
Number of live births	0.2	0.3	2.3	-0.8	0.1	0.0	-0.3	0.7	0.5	0.4	0.1	0.8	0.1	-0.6	-0.3	0.8	-0.0	0.0	-0.2	1.5
Tense / ‘highly strung’	0.2	0.3	1.0	-0.2	-0.7	0.0	-0.4	0.5	0.4	0.4	-0.0	0.3	0.5	-0.1	-0.3	0.5	-0.7	-1.0	0.9	0.4
High blood pressure (siblings)	0.2	0.3	0.5	-0.2	0.2	-0.7	-0.4	-0.7	-0.7	-0.7	-0.6	-0.0	0.4	0.1	-0.4	-0.7	0.4	-0.5	-0.2	-0.7
Number of children fathered	0.2	0.3	1.9	-0.2	-0.5	-0.6	0.6	-0.0	-0.5	-0.4	-0.5	-0.0	-0.2	-0.5	-0.3	-0.4	-0.2	1.4	-0.3	-0.0
Health satisfaction	0.2	0.2	1.4	-0.3	0.6	-0.3	-0.5	0.2	0.2	0.2	-0.1	0.6	0.8	0.1	-0.2	0.6	0.5	-1.2	-0.1	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	1.1	-0.4	0.1	-0.7	0.1	-0.2	-0.3	-0.2	-0.4	-0.6	-0.5	-0.2	-0.1	0.1	0.7	1.0	-0.9	0.7
Diabetes diagnosed by doctor	0.2	0.3	1.6	0.0	0.4	-0.5	0.2	-0.7	-0.7	-0.6	-0.6	-0.9	0.2	-0.1	-0.4	-0.7	0.8	-1.3	-0.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	1.4	0.3	0.3	0.0	1.0	0.0	0.2	0.1	-0.0	0.5	0.8	1.2	-0.5	0.2	-0.2	0.1	0.5	0.7
Medication: Gliclazide	0.2	0.2	0.9	0.1	-0.4	0.0	0.6	-0.5	-0.4	-0.3	-0.0	-0.5	-0.1	0.3	0.3	-0.7	0.7	-1.0	0.0	-0.5
Smoking status: Current	0.2	0.3	2.3	-0.2	-0.2	-0.3	0.3	-0.2	-0.4	-0.4	-0.2	-0.6	-0.7	1.5	-0.3	-0.3	0.3	0.5	0.4	0.3
Wears glasses or contact lenses	0.2	0.2	1.1	0.1	0.5	-0.2	-0.9	-0.1	-0.3	-0.2	-0.2	-0.5	0.1	0.1	0.6	-0.4	1.0	-0.7	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.2	-0.1	0.7	-0.3	1.0	0.0	-0.1	-0.1	-0.4	-0.4	0.4	0.1	0.1	0.1	0.8	1.1	-0.6	-0.3
High cholesterol (Self-reported)	0.2	0.3	1.6	1.2	-0.8	0.5	-0.1	0.3	0.2	0.1	0.5	0.2	-0.1	0.9	-0.1	-0.2	-0.8	-0.3	0.1	-0.5
Cholesterol lowering medication	0.2	0.4	1.2	0.1	-0.8	-0.2	-0.9	0.4	0.1	0.1	-0.2	0.7	1.1	0.4	-1.1	0.3	-1.0	-0.3	-0.3	-0.1
Pain experienced in last month	0.2	0.3	1.9	-0.4	0.7	-0.2	-0.2	0.2	0.2	0.4	-0.2	0.4	-0.2	0.4	0.6	0.6	0.2	1.4	-0.9	-0.9
Body Mass Index (BMI) (2010)	0.1	0.2	1.1	-0.1	-0.1	-0.1	0.1	0.2	0.2	0.1	-0.4	1.1	-0.1	0.6	-0.6	0.5	0.2	-0.3	-0.4	0.1
Blood Platelet Count	0.1	1.2	6.2	1.3	1.4	0.6	1.1	1.1	1.0	0.9	0.4	-0.2	0.8	0.3	0.5	1.3	0.3	1.8	0.5	2.5
Blood Red Count	0.1	1.1	2.7	-0.9	0.4	-1.4	-1.2	-1.4	-1.4	-1.3	-1.2	0.3	0.2	-0.0	-1.0	-1.0	0.1	0.1	-1.6	-1.6
Lung FVC	0.1	0.7	4.5	-0.3	0.7	-0.5	-1.6	-0.4	-0.2	-0.2	-0.3	0.4	0.7	-2.1	-0.8	0.2	0.2	-0.6	-1.3	0.5
Current tobacco smoking	0.1	0.2	2.3	-0.2	-0.1	-0.4	0.4	-0.2	-0.4	-0.4	-0.3	-0.2	-0.4	1.5	-0.5	-0.2	0.5	0.4	0.4	0.1
Impedance of leg (left)	0.1	0.3	1.2	0.5	-1.1	-0.2	0.2	-0.2	-0.2	-0.2	-0.3	-0.6	-0.3	-0.5	-0.3	-0.2	-0.4	0.6	0.8	1.0
Impedance of arm (right)	0.1	0.3	1.5	-0.0	-1.1	-0.2	-0.3	-0.5	-0.3	-0.5	-0.3	0.2	0.3	-0.6	-1.2	-0.3	-0.3	0.8	-0.7	0.5
Impedance of arm (left)	0.1	0.5	2.1	-0.3	-1.0	-0.6	-0.1	-0.7	-0.5	-0.6	-0.6	0.1	0.2	-0.8	-1.2	-0.4	-0.5	1.4	-0.8	0.0
Breast cancer (self-reported)	0.1	0.2	1.2	0.5	0.4	-0.1	-1.1	-0.1	-0.1	-0.0	-0.1	0.0	0.4	-0.7	-0.1	0.1	-0.4	0.0	-0.3	-0.1
Commuting to job workplace: Cycle	0.1	0.2	0.5	0.5	-0.2	-0.1	0.1	-0.1	-0.3	-0.2	0.1	-0.4	-0.6	0.2	0.4	-0.4	-0.6	-0.3	-0.7	-0.7
Hair Pigment	0.0	0.9	4.5	0.8	1.3	0.8	-0.5	0.5	0.6	0.6	0.6	0.5	1.5	0.3	0.6	0.6	1.2	-2.1	0.5	-0.8
Tanning	0.0	0.5	2.5	-0.4	-1.0	0.1	-0.7	-0.5	0.3	-0.3	0.2	-1.0	-1.4	-0.8	0.3	-0.1	-0.6	1.6	-0.2	0.4
Impedance of whole body	0.0	0.2	1.0	0.4	-1.0	-0.2	-0.3	-0.3	-0.2	-0.3	-0.2	-0.1	0.1	-0.8	-0.7	-0.1	-0.4	1.0	0.1	0.4

Hub : Genes

PAIP2B

Models

Trait associations