TWAS hub - VAMP5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0891	0.0321	8.9e-04	0.055	NA	0.053	NA	0.052	4.1e-06	NA	5.7e-06	NA	8.0e-06
2	GTEx	Pancreas	0.2860	0.0870	1.3e-03	0.093	NA	0.052	NA	0.039	1.0e-04	NA	3.2e-03	NA	9.3e-03
3	METSIM	Adipose	0.0468	0.0223	1.0e-02	0.034	-0.001	0.003	0.005	0.014	5.9e-06	5.1e-01	1.1e-01	5.1e-02	2.9e-03
4	NTR	Blood	0.0378	0.0121	1.0e-04	0.008	0.011	0.023	0.017	0.017	1.2e-03	1.1e-04	5.1e-08	2.5e-06	2.5e-06
5	ROSMAP	Brain Pre-frontal Cortex	0.0939	0.0339	2.7e-03	0.007	0.004	0.022	0.010	0.005	3.2e-02	8.6e-02	6.2e-04	1.4e-02	6.2e-02
6	YFS	Blood	0.3395	0.0347	0.0e+00	0.168	0.254	0.273	0.269	0.243	1.1e-52	1.3e-82	1.5e-89	3.5e-88	2.1e-78
7	TCGA	Breast Invasive Carcinoma	0.0846	0.0346	3.6e-07	0.009	0.042	0.041	NA	0.036	4.1e-03	3.8e-09	6.1e-09	NA	6.0e-08
8	TCGA	Brain Lower Grade Glioma	0.0630	0.0792	9.5e-04	0.045	0.014	0.018	NA	0.038	7.4e-06	8.2e-03	3.8e-03	NA	3.2e-05
9	TCGA	Lung Squamous Cell Carcinoma	0.0683	0.0304	2.2e-05	0.044	0.050	0.037	NA	0.035	9.1e-06	2.1e-06	4.4e-05	NA	6.3e-05
10	TCGA	Prostate Adenocarcinoma	0.1036	0.0448	7.0e-06	0.011	0.061	0.050	NA	0.025	2.3e-02	5.9e-07	5.4e-06	NA	1.2e-03
11	TCGA	Thyroid Carcinoma	0.0870	0.0370	7.0e-06	-0.002	0.046	0.026	NA	0.003	7.3e-01	2.8e-05	1.4e-03	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Prostate Cancer	7.4	10.4	44.1	4.3	3.1	4.6	-1.5	0.1	1.7	-2.3	6.6	-0.2	0.0	-3.1
Angina	4.7	6.2	23.9	-4.5	-1.4	-3.4	-1.2	0.6	-2.6	0.6	-4.9	-0.1	1.1	0.6
Angina (self-reported)	4.6	6.1	22.2	-4.4	-1.7	-3.3	-1.4	0.6	-2.8	0.3	-4.7	-0.5	0.8	0.2
Coronary Artery Disease (CAD)	4.4	5.2	14.6	-3.1	-2.4	-2.4	-2.0	-2.1	-2.4	-1.4	-3.8	-1.8	-0.5	-1.4
Trunk fat-free mass	4.3	24.8	52.7	-3.9	-7.3	-4.5	-5.3	-4.2	-5.0	-5.3	-3.8	-6.0	-3.6	-4.8
Trunk predicted mass	4.3	24.5	51.8	-3.9	-7.2	-4.4	-5.3	-4.2	-5.0	-5.3	-3.7	-5.9	-3.5	-4.9
Arm fat-free mass (right)	4.2	21.8	47.9	-3.4	-6.9	-3.7	-5.5	-4.3	-4.9	-4.7	-3.9	-5.3	-3.0	-4.3
Arm fat-free mass (left)	4.2	21.4	46.9	-3.3	-6.8	-4.0	-5.2	-3.8	-4.7	-4.8	-3.8	-5.6	-3.3	-4.4
Arm predicted mass (right)	4.1	21.1	47.7	-3.5	-6.9	-3.7	-5.3	-4.2	-4.8	-4.8	-3.8	-5.2	-2.9	-4.2
Arm predicted mass (left)	4.1	20.6	45.3	-3.3	-6.7	-3.9	-5.2	-3.8	-4.6	-4.7	-3.7	-5.3	-3.2	-4.4
Whole body fat-free mass	4.0	23.0	47.3	-4.0	-6.9	-4.6	-5.0	-4.3	-4.8	-5.0	-3.8	-5.5	-3.4	-4.5
Whole body water mass	4.0	22.9	47.7	-3.9	-6.9	-4.5	-5.0	-4.4	-4.8	-4.9	-3.9	-5.5	-3.3	-4.5
Basal metabolic rate	3.9	21.4	45.0	-3.9	-6.7	-4.6	-4.6	-4.3	-4.6	-4.6	-4.1	-5.3	-3.1	-4.2
Pulse wave reflection index	3.8	4.7	11.1	-0.9	-2.9	-1.0	-3.1	-0.7	-3.3	-2.6	-0.6	-2.1	-2.5	-1.8
Leg fat-free mass (left)	3.2	17.0	33.9	-3.8	-5.8	-4.4	-3.6	-4.0	-4.0	-4.1	-3.6	-4.7	-3.0	-3.8
Leg predicted mass (left)	3.2	17.2	34.1	-3.8	-5.8	-4.5	-3.7	-4.0	-4.0	-4.1	-3.6	-4.6	-3.0	-3.8
Leg fat-free mass (right)	3.2	17.2	33.5	-3.9	-5.8	-4.5	-3.8	-4.1	-4.1	-4.0	-3.6	-4.6	-2.8	-3.8
Leg predicted mass (right)	3.1	16.8	32.8	-3.8	-5.7	-4.3	-3.8	-4.0	-4.0	-4.0	-3.5	-4.6	-2.8	-3.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	6.9	-1.4	-2.5	-2.6	-1.8	-0.3	-2.6	-1.2	-2.3	-2.4	-1.8	-1.3
Pulse rate	2.9	4.9	8.2	2.9	1.7	2.8	2.2	0.2	2.1	2.6	2.0	2.4	2.4	1.9
Weight	2.7	13.2	27.5	-3.2	-5.2	-4.2	-3.1	-3.5	-3.6	-2.8	-4.5	-3.7	-2.2	-2.8
Illnesses of father: Heart disease	2.7	3.7	12.6	-2.7	-0.4	-3.6	-1.1	-2.4	-0.7	-0.2	-3.5	0.1	0.5	0.4
Major Depression (MDD)	2.5	3.0	6.8	-0.4	-1.7	-2.1	-1.4	-0.7	-1.4	-2.2	-0.8	-2.6	-2.4	-2.0
Medication: Atenolol	2.5	3.2	5.4	-1.9	-1.5	-1.9	-2.0	0.8	-2.3	-1.7	-1.1	-2.1	-1.9	-1.7
Impedance of arm (right)	2.5	11.6	27.5	1.4	5.0	0.4	5.2	2.0	3.8	3.9	1.1	4.1	2.7	3.8
Impedance of arm (left)	2.4	11.2	26.6	1.6	4.8	1.0	5.2	1.4	3.6	3.9	1.1	4.0	3.0	3.7
Medication: Atorvastatin	2.4	2.9	5.9	-0.8	-2.3	-1.3	-1.9	-0.5	-2.4	-1.9	-0.8	-2.1	-2.0	-1.5
Heart attack/myocardial infarction (self-reported)	2.4	3.1	11.5	-2.8	-1.8	-2.3	-1.1	0.3	-1.8	0.5	-3.4	-0.3	0.8	0.4
Sitting height	2.3	16.3	39.2	-2.3	-6.3	-2.2	-4.7	-4.5	-3.9	-4.4	-1.4	-5.0	-2.7	-4.3
Schizophrenia vs Biploar Disorder	2.1	2.8	6.0	1.6	0.9	2.1	0.6	1.3	1.3	2.3	0.3	1.7	2.5	2.1
Hand grip strength (left)	2.1	5.6	11.4	-1.9	-3.0	-1.8	-3.4	-2.3	-2.4	-2.3	-2.1	-2.5	-1.3	-2.2
Heart attack	2.1	2.7	10.3	-2.4	-1.8	-2.0	-1.3	0.5	-1.9	0.4	-3.2	-0.4	0.7	0.2
Hip circumference	2.1	9.1	19.5	-3.2	-4.1	-3.6	-2.6	-2.5	-2.7	-1.9	-4.4	-3.0	-1.5	-2.4
Alcohol drinker status: Never	2.1	2.5	7.7	-1.9	-2.8	-1.6	-0.2	-1.8	-1.7	-1.0	-1.2	-1.8	-0.9	-0.9
Ever had prostate specific antigen (PSA) test	2.1	2.4	7.2	-2.1	-2.2	-2.3	0.3	-1.6	-0.8	0.5	-2.7	-0.7	0.0	0.9
Alcohol drinker status: Previous	2.1	2.3	7.1	2.6	1.2	2.7	0.8	1.0	1.3	0.1	2.6	0.3	0.1	-0.4
Impedance of whole body	2.1	10.7	20.9	2.3	4.6	1.8	4.0	2.2	3.5	3.8	1.3	4.0	3.0	3.7
Hand grip strength (right)	2.0	5.5	10.0	-1.9	-3.2	-1.8	-2.8	-3.1	-2.2	-1.8	-2.5	-2.5	-0.9	-2.3
Type 2 Diabetes (T2D) (2018)	1.9	3.6	6.9	2.6	2.4	2.4	1.7	-0.9	1.9	1.2	2.5	2.1	0.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	13.0	2.8	2.5	3.6	1.5	1.4	2.7	0.1	3.1	0.6	0.1	-0.5
Standing height	1.9	18.4	34.6	-4.3	-5.9	-5.3	-3.4	-4.8	-4.0	-3.9	-4.0	-4.8	-2.2	-3.4
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	5.5	-1.5	-1.4	-1.2	-0.7	-0.9	-1.4	-2.3	-0.9	-2.1	-1.3	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	10.8	2.9	0.8	3.3	-0.3	-0.2	1.1	0.7	1.4	0.5	0.6	0.1
Birth weight of first child	1.8	3.3	8.9	-0.9	-3.0	-1.1	-1.8	-2.0	-2.5	-2.0	-0.7	-1.5	-1.8	-1.4
Neck or shoulder pain in last month	1.8	2.6	8.2	1.7	2.9	2.1	0.5	0.5	1.0	1.1	2.7	1.5	0.3	0.6
Heart disease (siblings)	1.8	2.2	8.7	-0.8	-1.6	-1.9	0.1	-2.8	-0.9	-0.2	-2.9	-0.7	0.0	-0.1
Height	1.7	32.7	61.0	-6.7	-7.7	-7.8	-3.4	-6.5	-4.7	-4.9	-5.8	-5.9	-3.1	-3.9
Diabetes (mother)	1.7	2.2	6.5	2.5	2.2	1.2	0.7	0.5	1.1	1.4	0.9	2.0	1.0	1.5
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	6.1	2.5	1.0	1.9	0.6	2.0	0.3	1.4	0.6	0.9	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	12.3	3.1	1.4	3.5	1.2	1.4	1.4	-0.4	3.5	0.2	-0.4	-0.3
Illnesses of siblings: Diabetes	1.7	2.1	10.5	-0.4	0.0	-1.1	0.7	-1.9	-0.9	1.0	-3.2	1.1	1.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	6.4	-1.8	-2.5	-2.1	-0.7	-2.1	-1.5	-2.5	-1.0	-2.1	-1.6	-1.6
Depression (self-reported)	1.6	1.9	4.8	-2.2	-1.2	-1.8	-0.8	-1.9	-0.9	-0.4	-2.0	-1.1	-0.7	-0.7
Pulse rate, automated reading	1.6	5.2	20.2	4.5	1.5	3.6	1.2	1.6	1.8	0.9	3.5	1.2	0.1	0.5
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.7	0.6	1.4	1.2	1.5	1.7	1.2	1.9	1.1	1.6	1.2	1.4
Happiness	1.5	1.8	4.1	-0.1	-0.9	0.1	-1.0	1.4	-1.1	-2.0	0.5	-2.0	-1.7	-1.8
Pulse wave Arterial Stiffness index	1.5	1.7	4.4	1.1	-1.6	0.7	-1.9	-0.9	-2.1	-1.3	0.5	-0.9	-1.1	-1.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.4	-0.5	-2.1	-0.7	-1.6	-0.7	-1.5	-0.7	-1.5	-1.8	-1.1	-1.3
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.6	1.9	-1.0	0.7	-2.1	-0.7	-1.4	-1.4	0.3	-0.8	-1.2	-1.5
Ever taken oral contraceptive pill	1.5	1.7	5.8	1.4	1.1	1.1	0.2	0.6	-0.0	-1.4	2.4	-1.0	-1.8	-1.3
Basal cell carcinoma (self-reported)	1.5	1.7	5.2	-0.7	-2.2	-1.4	-1.1	0.8	-2.3	-0.6	-1.6	-0.9	-0.9	-0.2
Blood White Count	1.4	10.5	24.6	4.8	3.2	5.0	2.1	2.1	3.1	1.9	4.7	2.5	0.9	2.3
Average weekly spirits intake	1.4	1.8	5.1	-0.2	-1.0	-2.1	0.4	-2.3	-1.7	-0.9	-1.7	-0.7	-1.4	-0.3
Relative age voice broke	1.4	2.1	4.4	0.4	2.1	0.4	2.1	0.8	0.8	1.6	1.3	2.1	0.8	1.7
Alcohol intake versus 10 years previously	1.4	2.0	3.7	1.4	1.9	1.1	0.8	1.8	1.1	1.3	1.7	1.5	1.0	1.6
Risk taking	1.4	2.0	6.8	2.6	1.4	2.5	-0.3	-0.7	1.4	0.4	2.0	0.6	0.5	-0.1
Alzheimer’s Disease (in father)	1.3	1.4	3.5	-0.4	1.2	-0.1	1.1	-0.7	0.9	1.6	-0.8	1.8	1.9	0.9
Crohns Disease (2012)	1.3	2.1	4.7	-1.5	-1.6	-0.6	-1.4	-0.4	-0.9	-2.2	-0.2	-2.0	-1.6	-2.0
Number of live births	1.3	1.8	5.7	-0.8	-0.9	0.9	-1.5	0.3	-0.1	-2.1	0.3	-2.0	-1.1	-2.4
Noisy workplace	1.3	1.6	6.0	0.2	-0.4	-0.4	-1.3	-0.2	-0.9	-2.5	0.4	-1.4	-1.9	-1.8
Exposure to tobacco smoke at home	1.3	1.4	3.8	0.1	0.2	0.6	1.0	0.3	1.9	1.4	-1.2	1.6	2.0	0.9
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.7	-1.0	-0.1	0.6	-0.6	2.4	0.2	-1.7	1.5	-1.7	-1.7	-2.3
Number of full brothers	1.3	1.7	3.8	1.9	1.3	1.5	0.8	-0.9	1.9	0.9	0.4	1.4	1.5	0.7
Heart disease (mother)	1.3	1.5	7.7	-1.4	-1.2	-2.0	-0.2	-0.8	-1.0	-0.1	-2.8	0.1	-0.0	0.5
Mineral and other dietary supplements	1.3	1.8	5.7	0.1	-1.2	-1.1	-1.4	-0.1	-2.4	-1.5	-0.3	-1.8	-1.6	-1.1
Smoking status: Current	1.3	2.1	5.6	2.4	1.6	1.3	0.2	-1.8	0.7	1.2	0.9	1.7	1.5	1.3
Ever had hysterectomy (womb removed)	1.2	1.3	2.9	0.0	-1.2	-1.4	-1.3	-0.8	-1.7	-1.1	-1.1	-1.1	-1.1	-1.0
Current tobacco smoking	1.2	2.0	5.0	2.2	1.5	1.0	0.5	-1.8	0.8	1.4	0.6	1.7	1.6	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.7	0.4	0.8	0.4	1.3	-0.4	0.9	1.8	-0.9	1.8	1.9	1.8
Impedance of leg (left)	1.2	5.7	9.5	2.2	3.0	2.0	1.9	1.7	2.3	2.8	0.8	3.1	2.7	2.9
Waist circumference	1.2	4.2	9.1	-1.4	-3.0	-2.5	-1.7	-1.5	-2.2	-1.4	-3.0	-1.9	-1.6	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.6	0.6	1.1	1.5	1.0	0.8	1.3	1.6	0.3	1.5	1.4	1.6
Leg fat mass (right)	1.2	4.5	11.6	-1.6	-3.4	-2.5	-1.7	-1.6	-2.1	-1.2	-3.4	-1.8	-1.3	-1.2
Medication: Gliclazide	1.2	1.3	4.5	0.4	1.0	0.3	2.1	-0.9	1.3	1.4	0.1	1.3	0.6	1.5
Rheumatoid Arthritis	1.1	1.5	4.6	-0.2	0.9	1.4	1.4	-1.0	2.1	0.7	0.6	1.3	1.9	0.3
Heel T-Score	1.1	8.9	24.0	2.2	3.1	4.3	4.2	2.6	4.9	1.8	3.2	1.3	1.0	0.8
Serious illness, injury or assault to yourself	1.1	1.3	2.2	0.5	-1.5	0.0	-1.5	-1.2	-1.2	-1.4	-0.0	-1.3	-1.5	-1.1
Trunk fat mass	1.1	4.6	15.7	-1.8	-2.9	-3.1	-1.4	-2.0	-2.2	-0.5	-4.0	-1.3	-0.8	-0.6
Lung cancer (father)	1.1	1.2	4.4	2.0	0.3	2.0	0.5	0.0	0.7	-0.1	2.1	0.3	-0.1	-0.4
Whole body fat mass	1.1	4.5	13.3	-1.6	-3.1	-2.7	-1.7	-2.0	-2.0	-0.9	-3.6	-1.6	-1.1	-1.1
Loneliness, isolation	1.1	1.5	4.1	-0.7	-2.0	-0.9	-0.7	-0.9	-0.9	-0.9	-1.9	-1.9	-0.5	-0.9
Medication for cholesterol	1.1	1.6	9.2	-1.7	0.1	-1.1	0.0	-3.0	0.1	-0.1	-1.8	0.4	1.1	0.1
Leg fat mass (left)	1.1	4.3	11.4	-1.4	-3.2	-2.4	-1.8	-1.8	-2.1	-1.1	-3.4	-1.7	-1.1	-1.2
LDL Cholesterol	1.0	1.6	6.0	1.6	-0.1	1.9	-1.1	2.5	-0.4	0.6	1.9	0.5	0.1	0.5
Blood Eosinophil Count	1.0	8.0	31.8	4.1	-0.5	3.3	1.2	0.4	0.8	-2.2	5.6	-2.2	-3.7	-1.7
Severe depression (siblings)	1.0	1.2	4.4	0.9	-2.1	0.6	-0.6	0.3	-1.0	-1.2	0.7	-1.2	-1.3	-0.8
Impedance of leg (right)	1.0	4.8	7.5	2.1	2.7	1.8	2.2	1.8	2.3	2.3	0.8	2.7	2.0	2.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.2	1.2	-0.7	-0.3	-1.6	1.6	-2.1	-0.9	-0.0	0.1	-0.4	0.6
Stomach or abdominal pain in last month	1.0	1.3	4.2	1.5	0.9	1.5	-0.5	1.2	0.6	-0.9	2.0	-0.2	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.3	-1.2	0.1	-1.8	1.1	-0.6	0.3	-1.6	-0.3	-1.0	-1.5	-0.5
Family relationship satisfaction	1.0	1.2	2.5	0.0	-0.5	0.0	-0.8	1.1	-0.7	-1.6	1.5	-1.1	-1.6	-1.5
Friendships satisfaction	1.0	1.3	2.5	-1.1	-1.3	-0.6	-1.3	0.9	-0.9	-1.5	0.1	-1.6	-1.1	-1.2
Breast cancer (self-reported)	1.0	1.2	2.4	-1.3	-0.8	-1.4	0.6	-1.3	-0.1	0.3	-1.6	1.0	1.2	1.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.8	0.5	2.0	0.2	1.4	-0.6	1.1	1.5	-0.3	1.3	1.2	0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.8	-0.9	1.0	0.7	1.5	-1.0	2.2	0.9	-0.0	1.2	1.0	0.4
Age started oral contraceptive pill	1.0	1.3	4.2	-1.7	-0.0	-2.0	1.3	1.4	-0.7	-0.2	-1.6	-0.4	-0.5	0.0
Breast Cancer	0.9	2.3	8.6	0.3	0.1	1.3	0.8	0.7	1.0	2.9	-0.6	1.7	2.5	1.8
Medication for hormone replacement therapy	0.9	1.0	3.7	0.5	-0.7	1.9	-1.2	1.5	0.3	-0.4	1.5	-0.5	-0.4	-0.7
Average weekly fortified wine intake	0.9	1.0	5.6	2.4	0.2	0.6	1.7	0.2	0.4	0.5	1.2	0.3	-0.1	0.7
Maternal smoking around birth	0.9	1.3	2.7	-1.7	-1.4	-1.6	-1.0	-0.3	-1.2	-1.0	-1.2	-0.9	-0.5	-0.7
Multivitamins +/- minerals	0.9	1.1	2.7	0.5	1.1	1.2	0.5	-0.3	1.6	1.0	1.1	1.3	1.1	1.1
Father’s age at death	0.9	1.2	3.8	0.3	1.3	0.6	1.9	1.3	1.0	1.0	0.7	1.2	0.6	0.9
Worrier / anxious feelings	0.9	1.6	3.2	-1.5	1.8	0.0	1.7	-0.2	1.7	1.2	-1.0	1.0	1.6	0.8
Medication: Amlodipine	0.9	1.3	3.4	-1.0	-0.6	-1.3	-1.2	0.9	-1.8	-1.0	-0.2	-0.9	-1.6	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	5.3	-0.1	0.2	1.5	-0.1	-0.4	1.3	-0.9	2.3	-0.3	-0.7	-0.7
Pulse wave peak to peak time	0.9	1.0	2.7	-1.5	0.9	-1.0	1.3	0.5	1.6	0.7	-0.6	0.3	0.7	0.9
Emphysema/chronic bronchitis	0.9	1.0	4.1	0.0	-1.3	-0.6	-0.7	-0.3	-2.0	-1.1	-1.2	-0.8	-1.2	-0.4
Medication: Omeprazole	0.9	1.0	4.4	2.1	1.0	1.0	-0.5	1.2	-0.7	0.8	-0.5	1.1	0.6	0.4
Comparative height size at age 10	0.9	5.1	8.5	-2.7	-2.7	-2.9	-2.1	-2.4	-1.8	-1.6	-2.9	-2.2	-0.6	-1.7
Eye problems/disorders: Cataract	0.9	1.0	3.4	1.4	1.3	1.6	-0.2	-0.1	0.9	-0.4	1.9	0.4	-0.3	-0.6
Osteoporosis (self-reported)	0.9	1.1	2.9	0.7	-0.1	1.1	-0.5	-0.9	0.8	-1.4	1.7	-0.7	-0.9	-1.6
Arm fat mass (left)	0.9	3.6	12.2	-1.5	-2.7	-2.5	-1.2	-1.6	-1.8	-0.7	-3.5	-1.6	-0.8	-0.9
Eye problems/disorders: Glaucoma	0.9	1.1	7.3	0.9	-0.2	-0.2	0.0	-2.7	0.3	-0.8	1.0	-0.8	-0.9	-0.8
High cholesterol (Self-reported)	0.9	1.6	7.3	-0.3	-1.0	-0.8	-0.9	2.7	-1.4	-0.9	-0.0	-1.1	-1.6	-0.8
Crohns Disease (2017)	0.8	1.8	4.6	-2.1	-1.3	-1.7	-0.3	-0.9	-1.4	-1.2	-1.8	-1.0	-0.9	-1.1
Hypothyroidism (self reported)	0.8	2.0	4.3	0.3	2.0	-0.4	2.1	-1.9	1.6	1.0	0.3	1.7	1.4	0.9
Pack years adult smoking proportion	0.8	1.2	2.9	-0.4	-1.1	-0.6	-0.5	-0.5	-0.2	-1.7	1.3	-1.4	-1.6	-1.4
Townsend deprivation index at recruitment	0.8	1.1	3.1	-1.3	-0.4	-0.6	-0.5	-1.4	0.4	1.2	-1.8	0.7	1.4	0.7
Body mass index (BMI)	0.8	3.2	7.6	-1.3	-2.7	-1.8	-1.7	-1.4	-1.8	-1.1	-2.8	-1.7	-1.3	-1.4
Forced vital capacity (FVC)	0.8	2.9	10.1	-2.2	-3.2	-1.1	-1.4	-1.1	-1.4	-1.4	-1.6	-2.1	-0.5	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.2	-1.0	-0.7	-0.7	-1.0	2.1	-1.4	-0.1	-0.2	-0.8	-1.5	-0.2
Illnesses of siblings	0.8	1.1	5.5	0.3	-0.0	0.7	-0.2	1.2	0.6	-1.2	2.4	-0.4	-1.3	-1.1
Arm fat mass (right)	0.8	3.3	10.0	-1.3	-2.6	-2.5	-1.1	-1.6	-1.6	-0.8	-3.2	-1.7	-1.1	-1.0
Loud music exposure frequency	0.8	0.9	4.6	1.5	-0.1	0.8	0.4	2.1	0.0	0.4	0.6	0.2	-0.3	1.0
Blood clot in the leg (DVT)	0.8	1.1	3.8	1.9	-0.4	0.7	-1.0	-1.4	-0.3	-0.7	1.4	-0.4	-0.9	-1.0
Medication: Paracetamol	0.8	1.4	2.4	-1.0	-1.2	-1.2	-1.5	-0.0	-1.1	-1.4	-0.7	-1.3	-1.6	-0.8
Wheeze or whistling in the chest in last year	0.8	1.5	3.4	1.2	0.9	1.1	0.7	1.6	0.1	1.9	-0.5	1.3	1.4	1.6
Age at first live birth	0.8	1.4	4.9	-0.2	1.5	0.6	1.6	-1.3	1.2	-0.4	2.2	-0.3	-1.1	-0.8
Health satisfaction	0.8	1.1	4.2	1.2	-0.8	0.2	-1.0	1.8	-2.0	-0.5	-0.5	-0.6	-0.6	-0.3
Medication: Ibuprofen	0.8	0.9	1.8	1.0	0.6	1.2	1.1	0.9	0.7	1.2	0.6	1.0	0.7	1.3
Number of full sisters	0.8	1.0	2.4	0.9	0.4	1.6	0.4	0.2	0.8	0.7	0.8	1.4	1.3	1.2
Chest pain or discomfort	0.8	1.2	4.6	0.2	-0.1	0.1	0.3	2.1	-0.8	1.4	-1.5	0.8	1.1	1.3
Age at last live birth	0.8	1.2	2.5	-0.2	0.5	0.7	-0.1	-1.6	0.7	-1.0	1.5	-1.3	-1.4	-1.6
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.3	1.0	1.8	0.1	1.0	1.2	0.8	0.8	0.5	1.2	0.4	0.6
Average weekly champagne plus white wine intake	0.8	1.1	3.7	0.4	-0.5	1.4	-1.9	1.1	-0.6	-0.2	1.1	-0.9	-0.6	-1.5
Hearing aid user	0.8	0.9	3.4	-1.0	-0.6	-0.4	-0.8	-1.8	-0.2	-0.7	1.1	-0.8	-0.7	-1.2
Irritability	0.8	1.3	3.3	1.2	1.8	1.1	1.3	1.1	1.3	1.0	1.2	0.9	0.7	0.9
Supplements: Calcium	0.8	0.8	2.9	1.7	0.0	1.3	-0.7	0.4	0.6	-0.3	1.2	-0.4	-0.2	-1.4
Pack years of smoking	0.8	1.2	2.7	-0.4	-0.7	-0.6	-0.3	-0.3	-0.1	-1.7	1.3	-1.4	-1.6	-1.5
Lung FEV1/FVC ratio	0.7	3.6	9.8	-0.5	2.3	-0.2	3.1	-0.8	1.4	2.3	-1.3	1.9	2.1	2.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.2	0.3	-0.9	-0.6	-0.1	1.0	-1.4	-0.2	-0.5	-1.0	-1.5	-0.7
Number of incorrect matches in round	0.7	1.1	3.9	-0.7	-0.3	-0.6	1.0	-0.7	0.2	1.4	-2.0	0.3	1.5	1.2
Pain all over the body in last month	0.7	0.8	3.1	-1.2	-0.4	-0.5	0.0	-0.7	0.7	0.4	-1.8	0.9	1.1	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.2	-1.0	-0.7	-1.2	-0.7	1.3	-1.0	-0.2	-1.8	-1.3	-0.7	-0.3
Headache pain in last month	0.7	1.3	4.5	2.1	0.5	1.6	-1.2	1.3	-0.3	-0.4	1.7	-0.1	-0.7	-0.2
Glaucoma (self-reported)	0.7	0.8	4.8	0.5	-0.2	-0.3	-0.2	-2.2	0.6	-0.8	1.1	-0.5	-0.7	-0.6
Number of children fathered	0.7	0.8	2.5	0.8	0.6	1.4	-0.2	-0.5	1.1	-0.4	1.6	-0.7	-0.6	-0.9
Eye problems/disorders: None of the above	0.7	0.8	2.2	-1.5	-0.5	-0.2	-0.2	1.1	-0.4	0.7	-0.9	0.7	1.3	1.3
Medication: Allopurinol	0.7	1.0	3.9	1.5	0.0	2.0	-0.2	0.0	0.8	0.7	1.2	0.9	0.9	0.5
Supplements: Vitamin C	0.7	0.9	3.0	-1.0	-1.7	-1.0	-0.8	-0.3	-0.8	-0.8	-0.4	-0.9	-0.9	-0.6
Smoking status: Previous	0.7	1.1	3.9	-1.9	-0.7	-1.1	0.8	-0.6	0.6	-0.2	-2.0	-0.5	0.8	0.2
Long-standing illness, disability or infirmity	0.7	1.0	4.9	-1.4	0.5	-2.2	0.1	-0.4	-0.8	-0.6	-1.0	-0.6	-1.2	-0.4
Illnesses of father: None of the above (group 1)	0.7	0.9	4.3	0.8	0.3	2.1	0.4	-0.2	0.8	0.3	1.8	-0.0	0.5	-0.2
Fractured/broken bones in last 5 years	0.7	0.9	3.8	1.9	0.7	1.0	0.1	-0.5	1.3	-0.3	1.3	-0.1	-0.1	-0.8
Commuting to job workplace: Cycle	0.7	0.9	5.1	-2.3	0.0	-1.3	0.5	0.1	-0.1	-0.2	-0.1	-1.0	-0.9	-0.6
Bipolar Disorder (2018)	0.6	1.0	2.8	-0.4	0.0	-0.7	-0.8	-0.4	-0.7	-1.3	0.6	-1.2	-1.7	-1.6
Irritable Bowel Disease (IBD)	0.6	1.5	6.2	-1.9	-1.2	-1.3	0.2	-0.7	-1.5	-0.5	-2.5	-0.6	-0.3	-0.3
Neuroticism (2016)	0.6	0.8	2.7	-1.3	-0.4	-1.7	0.4	-0.9	-0.3	0.5	-1.5	-0.2	0.6	0.7
Sensitivity / hurt feelings	0.6	1.1	3.3	-1.8	0.3	-1.2	0.6	0.3	-0.0	-1.3	-0.2	-1.4	-1.3	-1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.4	1.1	-0.8	1.0	-0.9	1.5	-1.0	0.4	0.6	-0.3	0.1	0.1
Diabetes (father)	0.6	0.8	2.9	-0.2	-1.2	-0.8	-0.3	0.5	-1.1	-0.5	-1.7	-0.7	-0.7	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	3.8	-0.0	-0.7	-0.7	-0.0	-1.9	-0.4	-0.7	-0.4	-0.5	-1.4	-0.2
High blood pressure (mother)	0.6	0.9	2.2	-0.7	0.9	-1.4	-0.8	-1.0	-0.3	-1.2	0.2	-0.1	-1.5	-1.1
Medication: Simvastatin	0.6	0.9	9.2	-0.2	-0.1	0.0	-0.2	3.0	-0.6	0.6	-0.2	-0.1	-0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.9	1.7	1.5	0.9	0.6	0.2	0.7	0.9	0.6	1.2	0.2	0.9
Falls in the last year	0.6	0.8	2.2	-0.2	1.5	-0.0	0.8	0.7	0.8	1.2	0.0	1.0	0.8	1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.4	5.4	0.7	0.7	0.8	-0.0	1.3	0.1	-1.2	2.3	-0.8	-1.5	-1.3
Prospective memory result	0.6	0.7	2.1	0.8	-0.9	0.8	-1.1	1.4	-0.3	-0.3	-0.3	-0.7	-0.6	-1.2
Hair/balding pattern: Pattern 4	0.6	1.4	4.5	1.2	2.1	0.5	1.1	0.4	0.4	1.3	1.2	1.5	0.8	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.2	-0.3	-1.2	-0.7	0.6	-0.1	-1.5	0.0	-1.4	-0.6	-1.1	0.7
Migraine (self-reported)	0.6	0.8	1.5	1.1	1.1	0.6	0.4	-0.7	0.3	1.2	-0.4	1.1	1.1	1.1
Medication: Seretide 50 evohaler	0.6	0.7	3.2	0.5	1.4	0.1	1.8	-0.8	0.4	0.2	1.0	0.0	-0.0	0.0
Leg pain on walking	0.6	0.8	3.2	-1.6	-0.7	-0.5	-0.6	-0.8	-0.3	-0.4	-1.8	-0.6	-0.0	-0.8
Commuting to job workplace: Walk	0.6	0.6	1.4	-0.7	-0.3	-1.1	-0.0	-0.6	-0.7	1.0	-1.1	0.1	0.6	1.2
Number of self-reported non-cancer illnesses	0.6	1.0	3.6	-0.4	-0.0	-1.4	-0.7	0.4	-1.6	0.5	-1.9	0.7	-0.0	0.9
Mother’s age at death	0.6	0.8	3.3	-0.1	-0.3	-0.7	-0.2	-1.8	-1.2	0.6	-1.5	0.2	0.4	0.4
Commuting to job workplace: Public transport	0.6	0.7	3.8	-0.4	0.3	-0.7	2.0	1.0	0.0	0.6	0.3	0.4	-0.3	1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.1	1.4	0.6	0.1	-0.4	0.5	-0.5	0.6	-1.4	1.0	0.7	0.8
Pain experienced in last month	0.6	1.1	4.2	-0.9	-2.0	-1.0	-0.3	-0.6	-1.0	-1.3	-1.0	-1.0	-0.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.6	1.6	-0.8	0.3	-0.8	-1.1	-0.5	-0.6	0.8	-0.6	-0.9	-1.0
Ulcerative Colitis (UC)	0.5	0.8	5.3	-1.1	-0.2	-0.5	0.6	-0.3	-1.0	0.6	-2.3	0.2	0.6	0.7
Age at First Birth	0.5	0.7	3.2	1.8	0.4	0.7	0.5	-0.8	-0.3	-0.1	1.3	0.5	-0.8	0.3
Bipolar Disorder (2011)	0.5	0.5	1.0	0.6	1.0	-0.5	-1.0	0.5	-0.5	-0.6	1.0	-0.1	-0.8	-0.7
Body Mass Index (BMI) (2010)	0.5	0.6	2.1	-1.2	-1.4	-0.4	-0.7	0.1	-0.1	-0.3	-1.4	-0.3	0.6	-0.5
Primary Biliary Cirrhosis	0.5	0.8	2.1	-1.5	-0.8	-1.2	-0.8	-0.1	-1.1	-0.5	-0.7	-1.1	-0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-0.7	-0.5	-0.4	-1.1	-1.0	0.6	0.7	0.5	0.8	0.4	1.2
BMI	0.5	2.7	5.8	-0.7	-2.2	-1.0	-2.4	-1.8	-1.9	-1.2	-1.7	-1.4	-1.0	-1.7
Hearing difficulty/problems: Yes	0.5	0.8	2.3	-0.1	-1.2	-0.8	-0.5	-1.1	-0.6	-1.2	0.1	-1.0	-1.5	-0.5
Relative age of first facial hair	0.5	1.0	3.2	-0.5	0.3	-0.5	1.6	-1.0	0.2	1.0	0.0	1.4	0.6	1.8
Supplements: Glucosamine	0.5	0.6	2.3	0.1	0.5	0.5	0.9	-0.7	1.5	0.7	0.5	1.0	0.9	0.2
Past tobacco smoking	0.5	0.9	2.4	1.0	-0.2	0.5	-0.8	1.1	-0.8	-0.4	1.5	-0.4	-1.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.3	-0.6	1.0	-0.3	0.7	0.2	0.5	0.8	-1.1	1.1	1.1	1.1
Financial difficulties in last 2 years	0.5	0.7	2.2	-0.9	-0.3	-1.0	-0.4	-0.2	-0.2	-1.5	-0.7	-1.1	-1.1	-0.5
Mouth/teeth dental problems	0.5	0.8	3.2	-1.4	-0.7	-1.0	0.2	-1.8	1.1	-0.0	-0.4	-0.6	0.4	-0.6
Diabetes (self-reported)	0.5	0.8	2.0	1.2	0.9	0.9	1.4	-0.1	0.9	-0.0	1.3	0.5	-0.8	0.3
Medication: Cholesterol lowering	0.5	0.8	1.5	-1.2	-1.0	-0.8	-1.1	-0.2	-1.1	-0.6	-0.2	-0.7	-1.2	-0.7
Illnesses of mother	0.5	0.6	2.9	0.1	-0.9	1.0	-0.8	1.7	-0.4	-0.4	0.6	-0.4	0.4	0.0
Breastfed as a baby	0.5	0.6	2.6	-0.9	-1.1	-0.4	0.1	1.6	-0.5	-0.1	-1.3	-0.3	-0.1	0.4
Gout (self-reported)	0.5	0.7	2.5	0.5	-0.3	1.6	-0.7	-1.0	0.6	0.2	1.0	0.9	0.7	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.8	0.2	1.1	-0.9	1.4	-1.7	1.1	0.9	-0.1	0.8	0.9	0.5
Forced vital capacity (FVC), Best measure	0.5	1.7	5.7	-2.2	-2.4	-0.6	-0.6	-0.8	-0.4	-1.0	-1.6	-1.5	-0.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.3	-1.5	-0.8	-0.1	0.5	-0.7	-0.0	1.0	-0.8	0.4	0.8	1.0
Alcohol intake frequency.	0.5	1.2	3.7	1.3	0.9	0.7	-0.6	-1.3	-0.1	-0.8	1.9	-0.8	-1.3	-1.2
Had major operations	0.5	0.6	1.5	-0.2	1.2	-1.2	0.5	0.0	-0.5	0.6	-0.6	1.0	0.6	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.4	-0.3	-0.4	0.5	-0.9	0.5	-0.6	-1.2	0.7	-0.9	-0.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.5	1.1	0.9	0.7	-0.3	1.2	-0.1	0.8	1.2	1.0	0.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.8	0.5	0.4	1.8	1.1	0.2	2.0	0.0	1.6	0.2	-0.3	-0.3
Guilty feelings	0.5	0.8	2.9	-0.8	0.0	-0.2	1.5	-1.7	1.2	0.7	-0.9	0.1	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	-0.8	-0.5	-0.9	0.6	-1.4	1.0	-0.7	-0.4	-0.7	-0.4	-0.8
Medication: Blood pressure	0.5	0.9	4.0	0.7	-0.1	-0.3	-0.5	2.0	-1.0	-0.5	0.5	-0.6	-1.6	-0.4
Ever depressed for a whole week	0.5	0.6	3.1	1.3	-0.1	1.8	-0.6	-0.5	-0.2	0.1	0.8	-0.4	-0.1	-0.2
Depression (Nagel 2018)	0.4	0.6	2.5	-0.2	0.9	0.3	1.6	-0.4	1.5	0.3	-0.1	0.5	0.4	0.1
Alzheimer’s Disease (in mother)	0.4	0.5	2.0	0.3	-1.4	-0.2	-0.7	-0.8	-0.4	0.8	-1.0	-0.7	0.2	-0.5
Ovarian Cancer	0.4	0.6	2.8	-0.5	0.2	-0.3	-0.1	-0.3	-0.0	0.9	-1.7	0.1	1.4	0.4
Triglycerides	0.4	0.6	2.4	-0.0	-0.3	-0.5	-0.5	0.2	-1.0	-1.2	0.2	-0.9	-1.5	-0.6
Ulcerative Colitis	0.4	0.6	3.3	-0.0	-0.9	0.1	-0.5	0.2	-1.2	-0.0	-1.8	-0.5	-0.2	-0.0
Blood Platelet Count	0.4	4.6	13.5	0.6	-3.7	-0.2	0.7	1.7	-3.1	2.5	-2.5	-0.5	0.6	3.2
Systolic Blood Pressure	0.4	2.0	4.1	1.9	1.5	0.3	0.3	2.0	1.4	1.0	1.7	1.9	0.7	1.4
Smoking Status	0.4	1.0	4.3	1.6	0.5	0.6	0.1	-2.1	0.5	0.5	-0.1	0.8	1.3	0.8
Cardiovascular Disease	0.4	1.4	3.6	1.8	-0.3	-0.7	-1.1	1.3	-1.7	-1.1	0.9	-0.2	-1.9	-0.0
Systolic blood pressure, automated reading	0.4	1.2	3.5	1.2	1.0	0.4	1.0	1.9	0.9	1.2	0.1	1.5	0.7	1.3
Medication: Co-codamol	0.4	0.5	2.1	-0.4	-0.6	-0.3	-0.8	0.2	-1.5	-0.1	-1.4	-0.3	-0.5	0.3
Trunk fat percentage	0.4	1.8	10.2	-0.8	-0.9	-2.0	0.1	-0.8	-0.9	1.1	-3.2	0.4	0.3	0.9
Hearing difficulty/problems with background noise	0.4	0.6	2.1	-0.0	0.6	0.0	1.3	-0.6	0.4	1.3	-0.2	0.6	0.3	1.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	0.4	0.6	-0.1	-0.4	-1.2	0.0	-1.2	-0.4	-0.9	-0.6	-1.0
Had menopause	0.4	0.5	1.5	-1.1	1.0	0.1	0.3	-0.0	0.6	-0.7	-0.3	-0.7	-0.4	-1.2
Had other major operations	0.4	0.5	1.9	-0.1	-0.9	-0.6	-1.0	-0.2	-1.4	-0.3	-1.1	-0.6	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.8	-1.8	-1.9	-0.8	-0.4	-1.1	-0.6	-0.5	-1.7	-1.2	0.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.3	0.4	0.6	-0.5	0.2	-0.4	-1.1	0.1	0.4	1.0	-0.4	1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.4	1.4	-0.1	-0.1	-0.4	-0.2	0.2	-0.3	-0.6	-0.8	-1.0	-1.1	-1.2
Body fat percentage	0.4	1.5	9.7	-0.5	-0.9	-1.7	-0.0	-0.6	-0.8	1.0	-3.1	0.4	0.2	0.8
Worry too long after embarrassment	0.4	0.7	2.6	-1.1	0.5	-0.6	1.6	-1.0	-0.3	1.1	-0.4	0.1	0.0	0.8
Medication: Aspirin	0.4	0.5	1.2	-0.2	0.3	-0.5	-0.5	1.1	-0.5	0.8	-1.0	0.8	0.4	0.9
Osteoarthritis (self-reported)	0.4	0.6	1.3	-0.4	0.8	-0.6	-0.2	0.2	-0.9	1.1	-1.1	1.0	0.4	0.7
Medication: Aspirin	0.4	0.5	1.4	-0.0	0.3	-0.5	-0.7	1.2	-0.7	0.7	-0.9	0.8	0.3	0.9
Medication: Lisinopril	0.4	0.6	1.5	0.7	-0.9	-0.4	-0.2	0.7	-1.1	-0.4	-0.0	-1.1	-1.2	-0.6
Ever smoked	0.4	0.6	1.6	-0.4	0.9	-0.6	0.1	-0.8	0.5	0.5	-1.2	0.6	1.2	1.1
Number of operations (self-reported)	0.4	0.6	2.6	-0.5	0.2	-0.7	0.2	-0.6	-0.7	0.7	-1.6	0.7	1.2	0.6
Diastolic blood pressure, automated reading	0.4	1.1	8.2	2.9	0.2	0.8	-1.1	0.6	-0.2	-0.1	1.2	0.4	-0.6	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.3	0.7	0.7	1.8	1.3	-0.4	1.8	0.5	1.5	0.1	0.9	-0.2
Cholesterol lowering medication	0.4	0.6	3.9	0.0	-0.0	-0.9	0.5	2.0	-0.2	-0.2	0.2	-0.6	-1.2	-0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.9	-0.2	-0.4	0.5	0.5	0.8	0.2	-1.4	0.4	-1.4	-1.3	-1.0
Schizophrenia (2018)	0.3	0.5	1.5	-0.9	-0.3	-1.1	0.4	0.2	-0.3	0.6	-1.2	0.2	1.0	0.8
Worry (Nagel 2018)	0.3	0.7	2.0	-0.7	1.0	0.3	1.4	0.9	0.6	1.3	-0.8	0.3	0.5	0.7
Alzheimer’s Disease (including proxy)	0.3	0.5	1.8	-0.1	-0.6	-0.4	0.0	-0.6	0.0	1.3	-1.3	0.2	1.0	0.1
Mean Putamen Volume	0.3	0.3	0.7	0.8	-0.0	0.8	0.1	-0.2	-0.3	0.7	0.1	0.6	0.6	0.7
Fasting Glucose	0.3	0.3	0.7	-0.1	-0.4	0.6	-0.8	0.8	-0.5	-0.4	0.8	-0.3	-0.8	-0.4
HbA1C	0.3	0.4	1.3	0.6	0.6	0.5	1.1	-0.6	-0.2	0.8	0.1	0.8	0.1	0.6
Lupus	0.3	0.5	1.3	0.9	1.0	0.8	0.7	-0.6	1.1	0.2	0.5	-0.1	0.2	-0.5
Waist Hip Ratio (WHR)	0.3	1.2	5.4	2.3	1.0	0.6	0.4	0.3	0.0	-0.4	2.0	0.6	-1.1	0.2
Allergy or Eczema	0.3	0.7	1.8	-1.0	-0.5	-0.9	0.8	1.4	-0.4	-0.1	-0.8	-0.9	-1.3	-0.4
Chronotype (morning person)	0.3	0.8	4.8	-0.3	-0.7	-0.2	-0.3	2.2	-0.7	0.8	-0.9	0.3	0.4	0.8
Number of treatments/medications taken	0.3	0.6	1.9	1.0	-0.2	-0.3	-0.5	1.0	-1.4	0.2	-0.0	-0.0	-1.2	0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-1.1	0.7	-1.0	0.3	0.4	0.2	-0.1	-0.6	-0.7	-0.6	-0.5
Vitamin and mineral supplements	0.3	0.4	3.2	-0.1	-0.4	-0.4	0.6	1.8	-0.7	0.4	-0.2	-0.3	-0.2	0.1
Qualifications: CSEs or equivalent	0.3	0.3	0.9	-0.1	-0.9	-0.0	-0.5	-0.9	0.1	-0.8	-0.7	-0.5	-0.2	-0.7
High blood pressure	0.3	0.8	2.2	0.3	-0.5	-1.1	-1.1	0.7	-1.5	-0.7	-0.4	-0.3	-1.4	-0.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.2	-1.1	0.3	-0.5	1.0	1.8	-0.2	0.8	-1.1	0.1	-0.2	0.5
Alcohol usually taken with meals	0.3	0.5	1.6	-0.0	-1.3	-0.2	-0.8	-0.3	-0.6	-0.1	-1.3	-0.9	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	0.2	-0.4	0.8	-0.3	-0.4	-0.3	-0.5	0.5	-0.9	-1.0	-0.5
Qualifications: None of the above	0.3	0.6	1.4	-0.6	-0.3	-0.3	0.3	-0.9	0.4	0.8	-0.7	1.1	1.2	1.1
Medication: Ramipril	0.3	0.4	1.6	0.2	-0.8	-0.2	-1.0	0.1	-1.3	0.7	-0.4	0.2	0.0	0.7
Neuroticism score	0.3	0.5	2.0	-0.4	1.2	0.5	1.4	0.0	0.8	0.8	-0.1	0.4	0.4	0.7
Time employed in main current job	0.3	0.3	1.1	0.8	1.0	0.2	0.1	0.4	0.3	0.1	-0.2	1.0	0.6	0.2
Asthma	0.3	0.6	1.3	-0.2	0.9	0.4	1.0	0.7	0.8	1.1	-0.4	0.7	0.9	0.7
Length of working week for main job	0.3	0.3	1.0	1.0	0.2	0.4	-0.2	-0.7	0.6	-0.2	0.9	0.7	0.2	0.1
Peak expiratory flow (PEF)	0.3	0.7	2.2	-0.4	-1.2	0.2	-0.3	-0.3	-0.6	-0.6	-0.6	-1.5	-1.1	-1.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	0.3	0.6	1.0	0.6	0.5	1.1	0.3	0.0	0.6	1.4	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.6	0.6	-0.4	0.2	-0.1	1.2	-0.3	-0.4	0.7	-0.4	-0.8	-0.5
Leg fat percentage (right)	0.3	1.1	7.5	-0.2	-1.4	-1.3	-0.3	-0.1	-0.7	0.5	-2.7	-0.0	-0.3	0.4
Exposure to tobacco smoke outside home	0.3	0.4	1.9	-0.4	0.5	0.8	0.2	0.7	0.6	-0.3	1.4	0.5	-0.4	0.7
Comparative body size at age 10	0.3	0.8	4.8	-2.2	-0.3	-1.1	0.5	-0.3	0.7	0.1	-1.2	0.5	0.6	0.2
Shortness of breath walking on level ground	0.3	0.4	1.1	0.1	0.8	0.4	0.3	0.7	0.2	0.5	-1.0	0.9	0.7	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	1.1	-0.2	-0.0	-0.5	-0.5	-1.0	-0.1	-0.4	0.2	-0.2	0.7
Mean time to correctly identify matches	0.3	0.6	1.4	-0.2	0.2	-1.0	1.2	-0.6	0.3	0.3	-0.7	1.1	0.3	1.2
Overall health rating	0.3	0.7	1.9	1.2	0.5	-0.4	-0.9	1.4	-1.1	-0.7	0.1	-0.5	-1.2	-0.4
Knee pain experienced in last month	0.3	0.4	1.4	0.4	1.2	-0.1	0.1	0.2	0.2	1.2	0.4	0.8	-0.1	0.7
Hypertension (Self-reported)	0.3	1.0	2.9	0.7	-0.5	-0.6	-1.3	0.9	-1.5	-0.9	-0.1	-0.7	-1.7	-0.5
Arm fat percentage (left)	0.3	1.2	7.7	-0.3	-0.4	-1.4	0.7	-0.3	-0.3	1.3	-2.8	0.6	0.5	0.9
Diabetes diagnosed by doctor	0.3	0.6	1.5	1.0	0.9	1.2	0.8	-0.2	0.7	0.1	0.9	0.6	-0.6	0.2
Asthma (self-reported)	0.3	0.5	1.1	-0.2	0.9	0.4	1.1	0.6	0.8	1.0	-0.2	0.8	0.7	0.8
Wears glasses or contact lenses	0.3	0.3	1.0	-0.8	0.1	-0.7	0.8	1.0	-0.4	0.1	-0.7	-0.3	-0.3	-0.2
Medication: Bendroflumethiazide	0.3	0.4	1.6	1.3	0.3	-0.9	0.5	-0.8	-0.0	-0.1	0.3	0.4	-0.7	0.1
Leg fat percentage (left)	0.3	1.1	7.7	-0.1	-1.3	-1.2	-0.6	-0.3	-0.8	0.7	-2.8	0.0	-0.0	0.4
Neuroticism (Nagel 2018)	0.2	0.6	1.9	-0.7	-0.1	0.2	0.8	0.9	0.2	-0.7	0.0	-1.4	-1.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.4	-0.4	-0.1	0.2	-0.6	0.8	-1.2	1.6	-0.4	0.2	0.7	0.1
HDL Cholesterol	0.2	0.3	0.6	0.2	0.2	0.7	0.5	-0.2	0.7	0.6	0.8	-0.2	0.6	-0.5
Schizophrenia (2014)	0.2	0.5	1.6	-0.8	0.2	-0.7	0.4	1.3	0.4	0.8	-1.0	0.0	1.0	0.4
Blood Red Count	0.2	1.7	4.9	2.1	0.7	1.2	0.0	2.2	-0.6	-0.7	1.7	-1.2	-1.6	-0.3
Respiratory disease	0.2	0.4	2.1	0.5	-0.5	0.2	-0.3	1.4	-0.8	0.1	0.3	-0.2	-0.6	0.1
Lung FVC	0.2	0.8	1.9	-0.5	-0.8	1.1	0.7	-0.2	0.8	1.4	-0.7	0.7	1.4	0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.5	0.6	-0.2	0.8	-0.8	0.6	0.2	-0.8	0.3	0.4	0.2
Supplements: Zinc	0.2	0.2	0.9	-0.2	-0.8	0.0	-0.3	-1.0	0.2	-0.1	0.3	-0.0	0.2	0.1
Medication: Metformin	0.2	0.3	1.1	0.4	1.0	0.1	1.1	-0.5	0.1	0.2	0.1	-0.1	-0.6	-0.2
Taking other prescription medications	0.2	0.3	0.8	0.3	0.9	-0.8	0.3	-0.5	0.1	0.0	-0.9	0.7	-0.2	0.3
Age when periods started (menarche)	0.2	0.6	1.9	0.3	-0.5	0.1	-1.3	0.9	-0.3	-1.4	0.7	-0.4	-0.6	-0.4
Medication: Levothyroxine sodium	0.2	0.3	1.3	0.2	0.7	-1.2	0.6	-0.7	0.4	0.3	-0.1	0.2	0.1	-0.2
Nervous feelings	0.2	0.3	1.4	-1.0	1.2	0.1	0.2	0.6	0.0	0.3	0.1	0.1	-0.6	-0.2
Allergy	0.2	0.5	2.6	0.3	-0.2	0.1	-0.4	-1.6	0.8	-0.5	1.0	0.3	0.6	0.2
Arm fat percentage (right)	0.2	1.0	6.2	-0.2	-0.2	-1.4	0.6	0.2	-0.1	1.2	-2.5	0.5	0.2	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.0	0.6	-0.1	0.4	0.9	0.0	0.3	-0.9	0.7	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.3	-1.5	-0.9	-0.0	0.1	-0.9	0.6	-0.1	-1.2	-0.4	0.5	-0.2
Tense / ‘highly strung’	0.2	0.3	1.1	1.0	-0.1	0.4	0.6	0.3	-0.6	0.9	-0.4	0.2	0.0	0.7
Birth weight	0.2	0.5	1.7	0.6	-0.6	-0.3	0.7	-1.3	0.3	-0.9	0.2	-0.8	-0.4	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	1.3	-0.6	0.3	0.2	1.2	-0.8	0.5	-0.0	1.0	-0.5	0.3	-0.8
Medication: Blood pressure	0.2	0.3	0.8	0.3	-0.3	-0.4	-0.8	-0.9	-0.2	-0.3	0.4	-0.5	-0.9	-0.6
Suffer from ‘nerves’	0.2	0.4	1.9	-0.8	-0.4	-0.4	0.4	0.4	-0.9	0.3	-1.4	-0.0	-0.1	-0.1
Average weekly red wine intake	0.2	0.3	1.6	0.2	-0.4	-0.2	-0.1	0.6	-1.3	-0.5	0.0	-0.5	-0.9	-0.2
Mood swings	0.2	0.3	0.9	-0.2	-0.4	-0.2	0.2	0.6	-0.6	-1.0	-0.8	-0.9	-0.1	-0.3
Ever had bowel cancer screening	0.2	0.3	1.3	0.0	-0.3	1.1	-0.3	0.0	-0.2	0.7	-0.8	-0.1	0.1	-0.5
Qualifications: nursing, teaching	0.2	0.4	1.4	-0.5	0.5	0.4	0.0	-0.0	0.1	1.0	-0.0	1.2	0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	0.2	0.4	0.5	-0.3	1.0	0.8	-0.2	0.9	0.2	-0.1	-0.0
Back pain experienced in last month	0.2	0.3	1.1	-0.6	0.9	0.1	-0.4	1.1	-0.1	0.1	-0.9	0.1	0.4	-0.4
Miserableness	0.2	0.4	1.0	0.1	1.0	1.0	1.0	-0.9	0.8	-0.2	0.5	0.0	-0.1	-0.3
Illnesses of father: High blood pressure	0.2	0.2	1.6	0.5	-0.5	-0.3	-0.1	0.5	-1.2	-0.3	-0.4	-0.1	-0.1	0.2
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.5	0.3	-0.8	0.6	-0.6	-0.7	-0.2	-0.3	0.6	-0.1	0.5
Unable to work because of sickness or disability	0.2	0.3	1.3	0.2	-0.5	0.2	-1.1	0.4	-0.9	-0.2	-0.6	-0.2	-0.1	-0.6
Myopia	0.2	0.2	0.7	-0.6	-0.4	-0.5	-0.3	0.0	-0.8	-0.1	-0.9	0.5	-0.2	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	1.6	-0.8	-0.2	-1.3	-0.2	-0.1	-0.7	-0.3	-0.6	-0.6	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	0.3	-0.5	0.6	-0.3	-0.8	-1.0	1.0	1.1	-0.3	-0.3	-0.3
Reaction Time	0.1	0.3	0.6	-0.2	0.3	-0.5	0.8	-0.7	0.5	-0.3	0.2	0.8	-0.1	0.8
Neuroticism	0.1	0.4	1.2	-0.0	0.2	0.8	1.1	0.4	1.1	0.5	0.6	-0.5	-0.2	-0.1
Hair Pigment	0.1	2.1	10.3	-0.4	-0.3	-1.8	0.0	-1.0	-0.7	1.5	-3.2	1.3	1.1	1.8
Tanning	0.1	1.1	4.5	0.8	0.5	2.1	0.1	0.8	1.1	0.5	1.8	0.6	0.7	0.4
Fed-up feelings	0.1	0.2	0.6	-0.8	-0.4	-0.2	0.3	0.6	-0.1	-0.3	-0.5	-0.4	-0.4	0.3
Fluid intelligence score	0.1	0.3	1.3	0.0	0.2	0.2	-0.3	1.0	-0.4	1.1	0.2	0.3	0.2	0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.5	-0.7	0.2	0.1	-0.2	0.4	0.3	0.1	0.7	0.8	0.2
Medication: Lansoprazole	0.1	0.1	0.4	0.5	0.1	0.6	0.3	0.3	0.1	0.2	-0.4	-0.1	0.4	0.1
High blood pressure (siblings)	0.1	0.2	0.7	0.2	0.2	0.1	-0.1	0.4	-0.2	0.8	-0.8	-0.0	0.6	0.4
Qualifications: College or University degree	0.1	0.3	1.6	0.1	-0.4	-0.5	0.2	0.2	-0.5	0.2	1.3	-0.7	-0.8	0.1
Financial situation satisfaction	0.1	0.2	0.5	-0.6	-0.0	0.0	0.3	0.3	-0.1	-0.7	-0.3	-0.5	-0.7	-0.0
Medication: Paracetamol	0.1	0.2	0.8	0.2	-0.2	-0.3	-0.9	0.4	-0.6	-0.2	0.3	-0.2	-0.8	0.1

Hub : Genes

VAMP5

Models

Trait associations