Best TWAS P=3.25e-08 · Best GWAS P=7.85e-15 conditioned to 5.18e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | SEC22A | 0.24 | 0.13 | lasso | 5 | 0.09 | 5.5e-04 | 5.3 | -5.3 | 1.0e-07 | 0.16 | 0.67 | 0.02 | FALSE |
| 2 | GTEx | Artery Tibial | SEC22A | 0.31 | 0.34 | lasso | 8 | 0.33 | 7.4e-27 | 5.3 | -5.4 | 6.7e-08 | 0.15 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | ADCY5 | 0.17 | 0.03 | lasso | 6 | 0.04 | 8.9e-04 | 5.3 | -5.5 | 4.8e-08 | 0.36 | 0.92 | 0.06 | FALSE |
| 4 | GTEx | Brain Cerebellum | SEC22A | 0.25 | 0.16 | enet | 29 | 0.17 | 1.3e-05 | 5.3 | -5.2 | 1.5e-07 | 0.14 | 0.97 | 0.00 | FALSE |
| 5 | GTEx | Colon Sigmoid | SEC22A | 0.16 | 0.12 | lasso | 3 | 0.11 | 1.2e-04 | 5.3 | -5.5 | 4.8e-08 | 0.14 | 0.37 | 0.03 | FALSE |
| 6 | GTEx | Colon Transverse | SEC22A | 0.18 | 0.11 | enet | 19 | 0.14 | 2.8e-07 | 5.3 | -5.4 | 8.7e-08 | 0.18 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Mucosa | SEC22A | 0.22 | 0.31 | lasso | 17 | 0.30 | 1.3e-20 | 5.3 | -5.4 | 5.1e-08 | 0.16 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Heart Left Ventricle | SEC22A | 0.11 | 0.09 | lasso | 5 | 0.08 | 7.0e-05 | 5.4 | -5.4 | 8.0e-08 | 0.15 | 0.89 | 0.01 | FALSE |
| 9 | GTEx | Liver | SEC22A | 0.21 | -0.01 | lasso | 5 | 0.00 | 2.3e-01 | 5.3 | -5.4 | 5.4e-08 | 0.14 | 0.10 | 0.12 | FALSE |
| 10 | GTEx | Lung | RP11-797D24.4 | 0.08 | 0.01 | enet | 10 | 0.03 | 4.1e-03 | 5.4 | -5.2 | 1.7e-07 | 0.50 | 0.14 | 0.68 | FALSE |
| 11 | GTEx | Ovary | SEC22A | 0.21 | 0.02 | lasso | 12 | 0.02 | 8.2e-02 | 5.3 | -5.3 | 1.0e-07 | 0.14 | 0.17 | 0.06 | FALSE |
| 12 | GTEx | Prostate | SEC22A | 0.26 | 0.22 | lasso | 3 | 0.19 | 1.5e-05 | 5.3 | -5.2 | 2.1e-07 | 0.16 | 0.39 | 0.04 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | SEC22A | 0.17 | 0.23 | enet | 14 | 0.25 | 1.0e-13 | 5.3 | -5.2 | 2.1e-07 | 0.13 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | SEC22A | 0.22 | 0.22 | enet | 25 | 0.23 | 3.3e-19 | 5.3 | -5.5 | 4.8e-08 | 0.10 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Stomach | SEC22A | 0.14 | 0.07 | enet | 24 | 0.04 | 4.7e-03 | 5.3 | -5.5 | 4.0e-08 | 0.16 | 0.76 | 0.01 | FALSE |
| 16 | GTEx | Thyroid | SEC22A | 0.17 | 0.20 | enet | 13 | 0.20 | 3.7e-15 | 5.3 | -5.4 | 7.3e-08 | 0.15 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Uterus | SEC22A | 0.33 | 0.17 | lasso | 5 | 0.10 | 3.9e-03 | 5.3 | -5.3 | 9.3e-08 | 0.16 | 0.16 | 0.06 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC22A | 0.01 | 0.01 | blup | 76 | 0.01 | 2.4e-02 | 5.3 | -5.5 | 3.2e-08 | 0.18 | 0.24 | 0.46 | TRUE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEC22A | 0.04 | 0.01 | blup | 76 | 0.04 | 2.1e-05 | -4.5 | -5.5 | 3.9e-08 | 0.27 | 0.31 | 0.60 | FALSE |