Best TWAS P=2.71e-22 · Best GWAS P=9.99e-28 conditioned to 5.35e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | 1.4 | 6.7 | 1.7e-11 | -0.52 | 0.08 | 0.87 | FALSE |
| 2 | GTEx | Brain Cortex | COPG1 | 0.24 | 0.00 | enet | 57 | 0.03 | 5.3e-02 | -9.4 | -6.4 | 1.3e-10 | 0.50 | 0.03 | 0.47 | FALSE |
| 3 | GTEx | Testis | HMCES | 0.75 | 0.56 | lasso | 8 | 0.55 | 8.4e-29 | 5.4 | 5.5 | 3.5e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 4 | METSIM | Adipose | COPG1 | 0.04 | 0.02 | bslmm | 303 | 0.03 | 7.6e-06 | 5.2 | -6.1 | 1.4e-09 | 0.33 | 0.78 | 0.02 | FALSE |
| 5 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -9.4 | 9.5 | 2.6e-21 | -0.84 | 0.11 | 0.41 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 5.6 | 9.7 | 2.7e-22 | -0.62 | 0.10 | 0.87 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -10.9 | 9.6 | 1.1e-21 | -0.65 | 0.00 | 0.69 | FALSE |