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chr5:12,225-1,135,834

Best TWAS P=6.55e-15 · Best GWAS P=4.59e-13 conditioned to 0.648

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AHRR	0.25	0.18	lasso	12	0.21	1.2e-25	7.1	7.1	1.1e-12	0.91	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SDHA	0.12	0.06	bslmm	290	0.11	8.6e-14	7.0	-6.2	4.2e-10	-0.86	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	SDHA	0.10	0.09	lasso	5	0.07	1.9e-06	7.1	7.1	1.3e-12	0.97	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	SDHA	0.10	0.05	lasso	3	0.07	1.5e-04	7.1	6.4	1.3e-10	0.90	0.01	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	CCDC127	0.13	0.03	lasso	4	0.05	9.0e-04	5.9	6.5	1.0e-10	0.74	0.08	0.88	FALSE
6	GTEx	Artery Aorta	PDCD6	0.26	0.17	lasso	4	0.14	2.8e-08	7.1	-6.6	4.7e-11	-0.99	0.01	0.99	FALSE
7	GTEx	Artery Tibial	PDCD6	0.22	0.07	lasso	4	0.06	2.1e-05	7.1	-5.7	1.2e-08	-0.94	0.01	0.99	FALSE
8	GTEx	Brain Cerebellum	CTD-2083E4.5	0.14	0.01	lasso	10	0.03	5.9e-02	5.4	-5.5	3.3e-08	-0.48	0.05	0.52	FALSE
9	GTEx	Brain Frontal Cortex BA9	AHRR	0.32	0.21	lasso	4	0.18	1.6e-05	7.1	6.8	9.6e-12	0.93	0.01	0.88	FALSE
10	GTEx	Cells Transformed fibroblasts	SDHA	0.23	0.18	lasso	2	0.17	1.6e-12	7.1	7.1	1.2e-12	0.99	0.01	0.99	FALSE
11	GTEx	Cells Transformed fibroblasts	CCDC127	0.25	0.13	lasso	5	0.14	9.0e-11	4.2	5.7	1.2e-08	0.78	0.04	0.96	FALSE
12	GTEx	Cells Transformed fibroblasts	CTD-2083E4.5	0.09	0.07	lasso	3	0.05	1.2e-04	7.1	-6.8	1.2e-11	-0.99	0.01	0.97	FALSE
13	GTEx	Heart Atrial Appendage	SDHA	0.15	0.04	lasso	3	0.02	4.3e-02	5.9	-6.1	1.4e-09	-0.69	0.09	0.69	FALSE
14	GTEx	Muscle Skeletal	CCDC127	0.20	0.08	lasso	8	0.10	4.3e-10	-1.9	-5.2	2.0e-07	-0.55	0.81	0.19	FALSE
15	GTEx	Muscle Skeletal	PDCD6	0.08	0.04	lasso	6	0.01	1.8e-02	7.0	-5.1	2.8e-07	-0.89	0.02	0.93	FALSE
16	GTEx	Nerve Tibial	CCDC127	0.05	0.01	lasso	4	0.02	2.2e-02	5.9	7.0	3.6e-12	0.86	0.04	0.82	FALSE
17	GTEx	Testis	SDHA	0.33	0.24	lasso	7	0.20	2.9e-09	4.3	6.7	2.0e-11	0.70	0.57	0.43	FALSE
18	GTEx	Thyroid	CTD-2083E4.5	0.07	0.06	lasso	2	0.04	3.6e-04	7.2	-7.6	2.7e-14	-0.99	0.00	0.98	FALSE
19	GTEx	Whole Blood	SDHA	0.05	0.01	lasso	5	0.01	3.4e-02	6.4	-6.2	5.8e-10	-0.90	0.02	0.92	FALSE
20	METSIM	Adipose	SDHA	0.09	0.04	lasso	12	0.03	8.5e-06	7.0	6.6	4.4e-11	0.95	0.01	0.99	FALSE
21	NTR	Blood	CCDC127	0.02	0.01	blup	284	0.02	1.5e-06	4.7	-5.4	6.7e-08	-0.62	0.17	0.82	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	AHRR	0.35	0.19	enet	29	0.28	1.4e-36	3.7	5.4	7.9e-08	0.67	0.22	0.78	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	SDHA	0.07	0.04	lasso	4	0.04	2.3e-06	4.7	-5.1	2.8e-07	-0.38	0.81	0.16	FALSE
24	YFS	Blood	PDCD6	0.03	0.03	bslmm	276	0.03	1.6e-09	7.2	7.8	6.6e-15	0.90	0.01	0.99	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHRR	0.04	0.03	lasso	3	0.03	1.1e-06	6.2	7.5	9.6e-14	0.57	0.44	0.41	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AHRR	0.10	0.01	blup	100	0.05	2.4e-06	6.4	6.5	8.2e-11	0.62	0.02	0.88	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRC14B	0.04	0.02	blup	63	0.01	2.0e-02	4.6	6.1	1.4e-09	0.54	0.09	0.26	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDCD6	0.03	0.02	blup	49	0.02	2.9e-03	7.0	7.1	1.7e-12	0.95	0.01	0.96	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDHA	0.04	0.03	blup	62	0.05	3.3e-06	7.2	7.7	1.9e-14	0.87	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AHRR	0.09	0.01	blup	100	0.06	2.7e-04	-4.4	5.9	3.4e-09	0.55	0.04	0.28	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRRC14B	0.08	0.04	lasso	5	0.03	6.7e-03	7.0	7.0	2.1e-12	0.97	0.01	0.96	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDHA	0.05	0.02	lasso	4	0.01	1.3e-01	4.3	6.0	1.6e-09	0.84	0.02	0.85	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	AHRR	0.30	0.17	lasso	3	0.25	7.9e-28	6.2	7.4	1.7e-13	0.51	0.75	0.25	FALSE
34	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AHRR	0.11	0.05	lasso	3	0.07	2.5e-04	7.1	6.9	6.1e-12	0.86	0.01	0.93	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	AHRR	0.05	0.01	blup	99	0.01	1.4e-02	4.2	6.5	5.9e-11	0.42	0.13	0.06	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	AHRR	0.12	0.04	blup	99	0.05	9.0e-06	4.2	5.6	2.5e-08	0.37	0.97	0.02	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	AHRR	0.04	0.03	blup	100	0.04	9.1e-04	3.7	6.9	5.0e-12	0.58	0.06	0.26	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	PDCD6	0.07	0.06	enet	5	0.07	2.0e-07	7.2	-6.8	1.3e-11	-0.91	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	SDHA	0.06	0.09	lasso	13	0.08	1.8e-08	7.2	7.1	9.8e-13	0.99	0.01	0.99	FALSE