Hub : Genes

CCDC127

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1940	0.0430	0.0e+00	0.184	0.159	0.205	0.190	0.192	6.2e-22	6.0e-19	2.2e-24	1.2e-22	7.8e-23
2	GTEx	Adipose Subcutaneous	0.0670	0.0330	1.3e-03	-0.002	NA	-0.002	NA	0.002	4.9e-01	NA	4.8e-01	NA	2.1e-01
3	GTEx	Adipose Visceral Omentum	0.1270	0.0590	5.3e-04	0.025	NA	0.040	NA	0.054	1.8e-02	NA	3.8e-03	NA	9.0e-04
4	GTEx	Artery Coronary	0.2710	0.1610	7.8e-03	0.016	NA	-0.003	NA	0.002	9.1e-02	NA	4.1e-01	NA	2.7e-01
5	GTEx	Brain Cerebellar Hemisphere	0.3810	0.0990	1.4e-07	0.304	NA	0.259	NA	0.258	1.6e-08	NA	2.5e-07	NA	2.6e-07
6	GTEx	Brain Cerebellum	0.4290	0.0980	1.5e-07	0.357	NA	0.346	NA	0.400	2.0e-11	NA	5.0e-11	NA	5.9e-13
7	GTEx	Brain Frontal Cortex BA9	0.1740	0.0924	7.5e-03	0.025	NA	-0.005	NA	0.020	7.1e-02	NA	4.5e-01	NA	9.5e-02
8	GTEx	Breast Mammary Tissue (Female)	0.1509	0.0861	2.6e-02	-0.005	NA	-0.001	NA	-0.007	4.7e-01	NA	3.5e-01	NA	6.1e-01
9	GTEx	Cells Transformed fibroblasts	0.2460	0.0670	2.3e-10	0.134	NA	0.134	NA	0.142	3.0e-10	NA	3.0e-10	NA	9.0e-11
10	GTEx	Esophagus Gastroesophageal Junction	0.1290	0.0650	5.8e-03	0.086	NA	0.015	NA	0.031	4.9e-04	NA	8.9e-02	NA	2.8e-02
11	GTEx	Esophagus Muscularis	0.0800	0.0340	7.4e-04	0.056	NA	0.055	NA	0.057	2.4e-04	NA	2.9e-04	NA	2.4e-04
12	GTEx	Muscle Skeletal	0.2008	0.0579	7.8e-09	0.078	NA	0.088	NA	0.101	4.5e-08	NA	5.4e-09	NA	4.3e-10
13	GTEx	Nerve Tibial	0.0540	0.0276	8.1e-03	0.011	NA	-0.004	NA	0.017	5.2e-02	NA	8.5e-01	NA	2.2e-02
14	NTR	Blood	0.0196	0.0076	3.7e-06	0.010	0.018	0.011	0.017	0.013	2.6e-04	1.5e-06	1.6e-04	2.5e-06	3.5e-05
15	ROSMAP	Brain Pre-frontal Cortex	0.1856	0.0426	0.0e+00	0.181	0.154	0.175	0.178	0.193	1.2e-22	2.6e-19	6.3e-22	2.3e-22	3.3e-24
16	TCGA	Breast Invasive Carcinoma	0.0301	0.0171	7.7e-05	0.011	0.017	0.016	NA	0.012	2.0e-03	1.7e-04	2.0e-04	NA	1.0e-03
17	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0980	0.0600	6.5e-03	0.052	0.030	0.056	NA	0.035	6.4e-04	7.3e-03	4.0e-04	NA	4.1e-03
18	TCGA	Thyroid Carcinoma	0.0460	0.0230	3.0e-04	0.024	0.036	0.042	NA	0.026	1.9e-03	1.7e-04	5.2e-05	NA	1.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	0.6	1.0	2.6	0.5	1.0	1.5	1.4	-0.1	0.4	-1.4	1.4	1.2	1.0	-0.4	-0.5	0.9	-1.6	-0.9	0.5	0.6	0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.6	-0.7	-0.3	-0.2	-0.3	-0.2	0.3	0.7	-0.9	0.2	0.5	0.1	-0.1	0.8	0.6	0.2	-0.7	-0.7
Depressed Affect (Nagel 2018)	0.5	1.1	3.1	-1.4	-0.5	-0.4	1.4	-1.3	-1.8	-1.3	1.3	-0.6	1.2	-0.7	-1.5	0.2	-0.0	0.2	-1.4	-0.7	0.3
Depression (Nagel 2018)	0.3	0.4	1.9	0.5	-0.7	-1.0	-1.1	0.3	0.2	-0.6	0.5	-0.1	-1.4	-0.2	0.2	-0.8	0.2	0.6	0.4	-0.1	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.2	0.5	0.8	0.8	0.6	0.6	0.4	-1.5	0.0	0.3	-0.3	-0.4	0.9	0.6	-0.9	-1.3	-0.6	0.6	0.2
Neuroticism (Nagel 2018)	1.3	3.1	8.9	-2.5	-1.1	-0.3	2.2	-3.0	-2.9	-2.2	0.7	-0.7	1.0	-1.6	-2.8	0.5	-0.2	-0.5	-2.6	-1.2	0.4
Schizophrenia (2018)	0.8	1.6	5.4	-1.1	-1.7	-1.5	-1.4	-0.3	-0.5	1.6	-0.5	-2.1	-0.5	0.9	0.5	-0.9	2.3	1.5	-0.1	-1.3	-1.6
Schizophrenia vs Biploar Disorder	0.9	1.2	3.8	1.1	0.9	0.3	-0.7	1.4	1.0	1.9	-0.2	0.0	1.0	1.9	1.6	0.3	0.6	1.6	1.0	1.0	0.2
Worry (Nagel 2018)	1.0	2.2	6.7	-2.2	-1.2	-0.4	1.8	-2.5	-2.4	-1.9	0.7	-0.4	1.0	-1.1	-2.6	0.4	-0.0	0.3	-1.6	-1.1	0.9
Alzheimer’s Disease (in mother)	0.8	0.9	3.0	-1.6	-0.8	0.1	-0.6	-1.5	-1.7	0.6	-1.6	-0.3	-0.1	-0.2	-1.4	0.7	-0.4	0.2	-1.1	-0.6	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	1.2	0.6	0.2	0.6	-0.5	1.0	0.4	-0.4	0.5	0.0	-0.1	1.1	0.4	0.7	0.3	0.5	0.7	0.5	0.8
Alzheimer’s Disease (including proxy)	0.7	1.0	3.4	-1.6	-1.3	0.3	-0.6	-1.2	-1.7	0.8	-1.9	-0.3	0.1	-0.4	-1.4	1.0	-0.2	0.1	-1.0	-0.6	0.3
Crohns Disease (2017)	0.8	1.7	4.4	1.1	1.9	2.0	1.2	1.4	1.1	1.3	-0.4	1.6	2.1	1.0	0.7	1.4	-0.3	0.4	1.3	1.4	0.9
Irritable Bowel Disease (IBD)	1.5	3.6	13.0	1.8	2.5	2.7	3.6	0.3	1.7	-0.8	0.7	2.3	2.9	0.3	0.8	1.6	-3.0	-1.0	0.8	1.1	1.6
Ulcerative Colitis (UC)	2.1	3.9	16.2	1.7	2.0	1.9	4.0	-1.0	1.5	-2.6	1.3	1.9	2.1	-1.0	0.5	0.8	-4.0	-2.2	-0.2	0.1	1.2
Major Depression (MDD)	0.3	0.3	0.9	-0.8	-0.7	-0.6	0.6	-0.8	-0.1	-0.3	-0.3	-0.9	-0.2	-0.1	-0.2	-0.6	1.0	-0.0	-0.2	-0.8	-0.5
Reaction Time	1.3	2.5	6.2	2.5	1.7	0.2	0.7	1.5	2.2	-1.3	2.4	1.2	0.4	2.0	2.1	-0.4	-1.2	1.6	2.2	0.8	1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	2.6	0.4	0.4	0.5	0.5	0.6	0.7	-0.8	0.2	-0.4	0.5	0.5	1.6	0.1	-0.1	-0.2	0.1	-0.2	-0.0
Breast Cancer	2.7	6.6	22.2	1.5	-1.4	-4.0	-3.3	2.0	2.4	3.0	-0.5	-2.4	-3.8	0.9	3.0	-4.7	2.9	1.2	1.1	-0.8	-2.4
Ovarian Cancer	3.2	4.2	12.9	-1.1	-1.8	-2.7	-3.6	0.0	-0.5	0.3	-1.7	-2.9	-3.4	0.3	0.7	-2.4	3.4	0.9	-0.5	-1.9	-2.4
Prostate Cancer	0.3	0.4	3.2	0.0	0.1	0.3	1.8	-0.6	0.4	-1.3	0.5	0.5	0.7	-0.2	-0.4	-0.1	-0.5	0.2	-0.6	0.3	0.1
Age at First Birth	1.3	1.8	6.4	-2.5	-0.9	0.6	1.2	-1.8	-2.5	0.1	-0.3	-0.3	1.4	-1.1	-2.5	1.5	0.7	-0.3	-1.5	-0.5	0.5
Bipolar Disorder (2011)	0.3	0.3	1.4	0.0	-0.6	-0.8	-0.7	0.0	0.0	0.0	0.4	-0.7	-1.2	0.2	0.3	-0.7	0.8	0.1	0.0	0.0	-0.7
Body Mass Index (BMI) (2010)	0.4	0.6	2.9	0.2	0.1	-0.2	-0.2	1.0	1.0	1.7	-1.1	-0.5	-0.1	1.1	0.7	-0.2	0.8	0.9	0.4	-0.3	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.8	-0.1	0.9	0.7	0.5	0.2	-0.3	0.1	0.1	0.0	-0.0	0.1	-0.1	0.5	-0.1	-0.3	-0.2	0.1	-0.2
Crohns Disease (2012)	1.7	2.8	8.4	1.0	2.5	2.9	2.0	1.1	0.5	0.9	0.8	2.3	2.3	0.4	-0.2	2.3	-1.6	-0.5	1.1	1.4	2.2
Mean Putamen Volume	0.8	0.9	2.3	-0.9	-1.3	-1.3	-0.7	-0.5	-0.7	1.0	-1.5	-1.3	-0.2	-0.8	-0.6	-0.8	1.5	-0.2	-1.1	-0.4	-1.1
Fasting Glucose	2.0	2.4	7.6	2.0	1.1	0.1	-0.5	2.2	2.0	1.8	2.7	0.7	-0.8	1.6	1.7	-0.6	0.6	1.7	2.4	0.6	1.3
HbA1C	2.4	2.6	7.2	0.2	1.9	2.5	2.5	0.7	0.1	0.4	1.5	2.0	2.7	1.1	-0.6	2.3	-0.8	1.3	0.8	1.0	2.4
HDL Cholesterol	0.5	0.8	2.3	-0.4	-1.1	-1.5	-0.3	0.2	0.1	0.9	-1.2	-1.4	-0.5	-0.4	0.4	-1.4	0.9	-0.3	-0.5	-1.2	-1.2
LDL Cholesterol	0.4	0.7	2.2	-0.8	-0.9	-0.9	1.1	-0.3	-0.9	1.2	0.6	-0.1	-0.8	-1.0	-1.5	-0.8	0.9	0.0	-0.8	-0.8	-0.2
Lupus	0.7	1.1	5.2	-1.0	-0.4	0.8	1.1	-1.6	-1.1	-2.3	1.5	-0.0	0.8	-0.4	-1.1	0.9	-0.6	-0.1	-0.9	-0.8	0.5
Neuroticism (2016)	0.5	0.8	2.5	-0.6	-0.4	0.1	1.5	-1.6	-0.9	-1.1	1.1	-0.0	0.9	-0.2	-1.3	0.9	-0.5	0.1	-1.1	0.2	0.4
Primary Biliary Cirrhosis	0.9	1.3	3.6	-0.3	1.0	1.8	0.7	-1.4	-0.8	-1.3	1.7	0.9	-0.4	-0.6	-1.2	1.9	-1.2	-0.8	-0.6	0.8	1.3
Rheumatoid Arthritis	1.0	1.4	5.7	1.4	1.2	0.9	0.2	1.9	1.3	1.0	0.8	1.1	0.7	1.2	1.3	0.3	-1.1	0.4	2.4	1.0	1.0
Schizophrenia (2014)	0.1	0.3	0.9	-0.0	0.3	0.7	-0.1	0.7	0.2	0.9	0.9	-0.4	0.8	0.9	0.6	0.6	0.5	0.4	0.6	-0.1	-0.0
Triglycerides	0.4	0.6	2.1	-0.0	-0.3	-1.1	0.3	-0.6	0.0	-1.1	-0.1	-0.3	-0.7	-1.5	-0.1	-1.2	-0.1	-1.4	-1.0	-0.4	-1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	-0.5	0.9	1.2	1.6	-0.6	-0.1	-0.4	1.2	1.0	1.4	0.7	-0.8	1.0	-0.6	0.9	0.8	0.0	1.5
Ulcerative Colitis	0.7	1.0	6.6	0.4	0.5	0.7	2.6	-1.2	0.3	-0.4	0.3	0.4	1.4	-0.3	-0.1	0.3	-2.2	-0.9	-0.8	-0.1	0.5
Blood Eosinophil Count	0.3	2.1	5.9	-2.1	-2.0	-1.1	-0.8	1.0	-1.6	-0.0	-2.4	-1.7	1.1	-0.6	-1.0	-0.8	2.4	0.7	-0.7	-2.2	-0.7
Blood Platelet Count	0.6	7.4	19.7	-0.9	3.3	4.4	3.3	-0.9	-1.4	-2.9	0.7	3.4	2.6	-2.2	-2.6	4.0	-3.8	-2.9	-1.1	1.6	2.4
Blood Red Count	0.1	1.2	11.2	0.9	0.8	0.4	0.1	0.0	0.8	0.7	3.4	1.3	0.5	0.6	0.6	0.2	-1.4	0.2	0.8	0.9	1.4
Blood White Count	0.3	2.4	6.9	-1.1	0.4	1.3	1.4	-1.0	-1.8	-2.2	0.1	1.4	1.4	-2.6	-2.2	1.4	-1.9	-2.2	-1.3	0.0	0.8
Heel T-Score	0.3	2.0	5.7	-0.2	-1.1	-2.1	-0.8	1.1	0.9	1.1	-0.9	-1.9	-1.9	0.5	1.2	-2.4	2.1	0.4	-0.4	-1.6	-2.0
BMI	1.0	5.6	14.4	-2.5	0.2	2.2	2.1	-2.9	-3.0	-1.7	0.8	2.5	3.2	-2.0	-3.8	3.1	-3.1	-1.1	-0.8	0.9	2.7
Height	2.2	42.7	118.8	0.2	7.7	10.9	7.6	-2.1	-2.1	-3.8	3.6	9.2	7.0	-3.9	-4.3	10.4	-9.7	-6.4	-0.9	6.0	7.0
Waist Hip Ratio (WHR)	0.6	2.7	7.8	-0.5	1.3	1.9	2.5	-1.6	-0.8	-2.2	1.9	1.8	1.4	-1.3	-1.9	1.7	-2.8	-1.4	-0.6	0.4	1.4
Systolic Blood Pressure	1.2	6.0	23.7	0.1	2.0	1.7	3.4	-1.6	-0.9	-3.2	0.7	2.3	1.4	-3.9	-0.9	1.5	-4.6	-4.9	-2.2	0.5	0.5
Smoking Status	0.5	1.2	4.3	0.8	0.9	0.6	-0.8	1.8	0.7	0.6	1.7	0.0	0.7	2.1	1.0	0.3	0.9	1.7	1.4	0.3	0.3
Allergy or Eczema	0.6	1.5	4.2	-1.2	-1.2	-0.8	0.2	-1.2	-1.0	-0.6	-1.7	-1.1	0.3	-2.0	-1.2	-0.6	0.6	-1.6	-1.8	-1.0	-1.5
Cardiovascular Disease	1.2	4.0	13.4	-0.6	0.6	0.9	1.7	-2.2	-1.9	-3.0	0.3	1.7	0.2	-3.6	-1.9	1.4	-2.8	-3.7	-2.4	0.8	1.4
Hypothyroidism (self reported)	0.3	0.6	3.8	0.3	-0.3	-0.8	-2.0	1.1	0.3	0.5	0.2	0.0	-1.2	0.3	0.3	-0.6	0.9	0.8	0.4	1.0	0.3
Respiratory disease	1.1	2.5	7.5	-2.7	-2.3	-0.5	-2.3	-1.6	-1.9	0.4	-2.3	-0.4	-1.4	-1.2	-2.7	0.5	1.5	0.3	-1.0	0.3	-0.3
Type 2 Diabetes (T2D) (2018)	1.1	2.0	6.4	-1.9	0.1	1.2	1.6	-1.6	-2.0	-0.1	-0.3	0.9	2.5	-1.3	-2.1	1.7	-0.9	-0.6	-1.4	0.5	1.6
Lung FEV1/FVC ratio	1.4	7.3	19.7	3.6	3.0	2.0	1.8	1.2	2.7	-0.1	4.1	3.4	2.0	2.4	1.6	1.6	-4.4	1.1	3.8	3.0	2.3
Lung FVC	0.2	0.9	6.5	1.1	0.8	0.1	0.8	-0.1	1.1	-0.1	0.4	0.3	-0.3	-0.9	0.9	-0.8	-2.6	-1.2	-0.6	-0.5	-1.0
Neuroticism	1.6	3.8	11.4	-2.9	-1.7	-0.7	1.7	-3.4	-3.3	-2.6	0.8	-0.9	0.8	-1.9	-2.9	0.3	-0.2	-0.3	-2.7	-1.7	0.2
Chronotype (morning person)	1.2	2.8	6.8	-0.2	-1.7	-2.4	-0.3	-1.3	-0.2	-0.5	-1.9	-2.3	-1.4	-1.6	0.8	-2.3	0.5	-1.6	-2.2	-2.2	-2.6
Hair Pigment	0.1	1.7	6.0	-0.6	-0.8	-1.8	-0.5	-2.5	-0.4	-0.3	0.9	-1.9	-1.5	-0.5	-0.6	-1.4	0.9	-0.1	-1.3	-2.2	-2.0
Tanning	0.3	4.0	14.8	1.7	3.7	2.8	1.1	0.8	1.0	-1.2	1.0	2.2	0.1	-1.4	1.1	1.9	-3.9	-3.3	-0.2	1.7	1.1
Hand grip strength (left)	1.3	3.5	9.4	1.0	2.6	3.1	1.8	0.5	0.9	0.7	0.9	2.9	2.7	0.7	0.1	2.5	-2.7	-0.5	1.5	1.8	2.0
Number of treatments/medications taken	0.9	1.5	5.6	-1.8	-1.4	-0.4	0.3	-1.8	-2.4	-1.3	-1.4	-0.8	-0.3	-1.0	-1.8	0.4	0.7	-0.4	-1.9	-0.4	0.4
Average weekly spirits intake	0.8	1.0	3.1	-1.0	-1.4	-1.4	-1.6	-0.5	-0.6	0.8	0.9	-1.0	-0.8	0.7	-0.4	-0.7	1.8	1.4	-0.4	0.0	-0.7
Sensitivity / hurt feelings	1.8	3.1	9.7	-2.0	0.1	1.4	1.6	-2.7	-2.9	-1.1	0.0	0.8	1.1	-1.9	-3.1	2.2	-1.1	-1.0	-2.4	0.3	1.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.8	0.3	-0.3	-0.5	-1.2	0.2	0.3	-0.8	1.9	0.4	-1.2	0.3	-0.4	-0.3	0.3	1.1	0.9	0.8	0.8
Hearing difficulty/problems: Yes	0.2	0.3	1.5	0.2	-0.4	-0.2	-0.9	0.5	0.3	0.1	-1.2	0.1	-1.0	-0.3	0.1	-0.2	0.3	-0.2	0.8	-0.5	0.4
Relative age of first facial hair	1.1	2.2	5.2	-0.6	1.2	1.5	1.1	-0.6	-0.8	-2.3	1.6	1.9	0.6	-2.2	-2.0	1.5	-1.7	-1.6	-1.3	1.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	-0.9	-0.4	0.5	-0.7	-0.7	-1.1	0.7	-0.6	0.4	0.0	-0.8	-1.2	1.0	-0.5	-0.1	-0.8	0.7	0.6
Ever used hormone-replacement therapy (HRT)	1.8	2.3	5.2	1.1	-1.0	-1.6	-2.1	1.7	1.3	1.3	-0.8	-1.5	-1.7	1.8	1.7	-1.7	2.3	1.9	1.4	-0.4	-0.9
Ever had hysterectomy (womb removed)	0.2	0.2	1.2	0.7	-0.0	0.3	-1.1	1.0	0.3	-0.4	-0.4	0.0	-0.4	-0.0	0.5	-0.0	-0.1	-0.6	0.4	0.1	-0.1
Systolic blood pressure, automated reading	1.2	3.4	13.8	0.2	1.6	1.7	2.3	-1.2	-0.7	-2.4	1.1	2.3	1.3	-2.3	-0.7	1.6	-3.7	-3.0	-0.8	0.8	1.5
Eye problems/disorders: Diabetes related eye disease	3.3	3.6	9.7	-2.3	0.4	1.9	0.5	-2.7	-2.4	-3.1	-1.8	0.3	1.1	-2.2	-2.3	2.2	-1.0	-2.6	-2.4	-0.5	0.4
Angina	1.0	1.4	4.4	-1.2	-0.8	-0.6	-0.4	-1.5	-1.4	-2.1	-1.3	-0.4	-0.9	-1.9	-1.2	-0.3	-0.7	-1.5	-1.4	-0.9	-0.3
Medication for hormone replacement therapy	0.7	0.8	2.3	0.8	-0.2	-0.9	-0.8	1.1	0.8	1.0	0.9	-0.6	-1.2	1.1	0.7	-1.1	1.1	1.5	0.9	-0.1	-0.2
Vitamin and mineral supplements	0.7	1.0	4.5	0.3	-0.6	-1.7	0.6	0.0	1.2	1.7	-0.2	-0.7	-0.9	-0.3	1.1	-2.1	0.2	-0.3	0.2	-0.9	-0.9
Supplements: Zinc	0.3	0.4	1.2	-0.5	0.7	0.7	-0.5	-0.1	-0.8	-0.2	-0.1	0.4	0.5	0.4	-0.4	1.1	0.2	0.6	-0.6	1.0	0.8
Medication: Co-codamol	0.9	1.0	4.7	0.0	-0.8	-0.7	-0.0	0.5	0.9	1.3	0.7	-0.7	-0.1	1.5	0.2	-0.8	1.8	2.2	1.3	-0.0	0.6
Medication: Metformin	1.9	2.7	7.3	-0.3	1.7	2.4	1.9	-0.6	-0.9	-1.1	0.6	1.9	2.6	-1.4	-0.9	2.0	-2.7	-2.0	-0.7	1.0	2.0
Diabetes (father)	0.3	0.4	1.6	-1.1	-0.1	0.8	-0.0	-0.2	-0.7	-0.2	0.4	0.1	1.3	0.3	-0.5	0.9	-0.3	0.3	0.3	-0.6	0.4
Diabetes (mother)	1.4	1.8	9.2	-0.8	0.6	0.8	1.5	-0.4	-1.3	-0.2	-1.5	0.0	1.8	-2.1	-0.6	0.6	-1.4	-3.0	-1.5	-1.2	-0.1
Severe depression (siblings)	0.4	0.5	1.5	-0.3	-0.3	-0.4	-0.6	0.8	0.1	-0.7	-0.5	-1.0	-0.8	1.0	0.3	-0.5	1.2	0.9	0.8	-1.0	0.0
Pack years adult smoking proportion	0.5	0.7	2.3	1.5	0.7	0.3	-0.9	1.2	1.5	1.0	-0.8	0.1	-0.7	0.7	1.5	-0.4	-0.2	0.2	0.5	0.4	-0.4
Impedance of leg (right)	0.1	0.5	2.3	-0.3	0.8	1.2	1.3	-0.4	-0.6	-0.6	1.5	-0.0	0.4	0.7	-0.6	1.2	-0.2	0.3	-0.4	-0.2	0.1
Leg fat-free mass (left)	1.6	8.3	21.9	-1.1	2.1	4.0	1.8	-2.0	-1.7	-2.1	0.4	4.2	2.9	-3.0	-3.0	4.3	-4.7	-3.1	-0.9	2.8	3.1
Trunk fat percentage	2.4	9.6	24.6	-2.4	1.3	3.9	2.2	-3.2	-3.3	-3.4	1.6	3.6	2.7	-1.8	-4.3	5.0	-4.8	-1.4	-0.7	1.1	4.2
Hand grip strength (right)	0.9	2.6	7.8	1.2	2.7	2.5	1.6	0.6	1.4	0.8	0.5	2.2	2.1	0.5	0.8	1.6	-2.8	-1.0	1.3	1.0	1.2
Townsend deprivation index at recruitment	1.0	1.3	4.5	1.1	0.3	0.4	-0.9	2.0	1.7	1.7	1.0	-0.0	0.1	1.6	1.2	-0.2	0.9	1.1	2.1	0.6	0.5
Current tobacco smoking	0.5	0.8	3.1	0.3	-0.2	-0.4	-0.8	1.0	0.7	-0.0	-0.4	-0.7	0.4	1.8	0.9	-0.6	1.6	1.2	1.2	-0.5	-0.9
Average weekly fortified wine intake	2.0	2.4	5.3	-1.6	0.0	1.3	2.0	-1.7	-2.2	-2.1	-0.2	0.9	2.3	-1.5	-1.9	1.9	-1.1	-1.6	-1.6	-0.0	0.9
Maternal smoking around birth	1.1	1.6	6.3	-0.8	-1.3	-0.9	-0.5	-1.3	-0.9	0.1	-1.3	-1.4	-1.3	-1.9	-0.5	-0.5	0.1	-1.7	-2.5	-0.9	-1.8
Fed-up feelings	0.6	1.1	3.7	-1.0	-0.4	-0.3	0.9	-1.7	-1.6	-1.5	0.9	-0.6	-0.5	-1.5	-1.5	0.2	-0.1	-0.7	-1.9	-0.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.5	-0.8	-0.8	-0.7	-1.1	-0.5	-0.9	0.6	0.0	-0.9	-0.9	-1.0	-0.2	-0.1	-0.1	-0.3	0.1	-0.2
Relative age voice broke	0.2	0.3	3.0	-0.4	0.3	0.6	0.1	-0.3	-0.2	-1.7	-1.0	0.3	-0.1	-0.6	-0.7	0.5	0.1	-0.3	-0.2	-0.0	0.2
Taking other prescription medications	0.7	1.1	4.7	-1.5	-1.1	0.4	-0.0	-1.0	-1.9	-0.7	-0.4	-0.0	-0.3	-0.6	-2.2	1.2	1.0	0.1	-1.1	0.2	1.1
Age when periods started (menarche)	0.1	0.3	1.0	-0.2	-1.0	-1.0	-0.1	-0.6	0.1	0.5	0.4	-0.4	-0.4	0.1	-0.1	-0.8	0.3	0.5	0.3	-0.9	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	3.1	0.9	0.2	-0.1	0.1	1.8	0.4	0.0	-1.5	0.3	0.8	-0.3	0.8	-0.2	-0.7	-1.1	0.4	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.0	-1.5	0.4	0.5	2.0	-1.3	-1.4	-0.9	-0.0	-0.2	0.8	-1.3	-1.5	0.5	-0.3	-1.3	-1.3	-0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	-0.7	-0.5	-0.2	-1.0	-1.0	-0.6	-1.0	-0.9	-0.4	-0.7	-0.7	-0.2	0.2	0.4	-0.8	-0.9	-0.0	-0.7
Qualifications: CSEs or equivalent	0.9	1.2	2.9	1.1	1.7	1.2	0.4	1.6	1.4	1.1	0.7	1.1	1.5	0.9	0.9	0.7	-0.5	0.4	1.4	1.5	0.6
Serious illness, injury or assault to yourself	1.5	1.9	6.2	-0.5	0.7	1.5	1.0	-0.6	-1.4	-0.5	0.7	2.0	0.9	-1.5	-2.5	2.0	-1.3	-0.7	-0.5	1.8	1.9
High blood pressure	0.4	1.0	3.9	-0.4	-0.7	-0.0	-0.2	-1.0	-1.4	-1.0	-0.7	0.6	-0.6	-2.0	-0.9	0.6	-1.4	-1.8	-1.0	-0.1	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.8	-1.0	-1.1	-0.6	-0.3	-0.3	-0.4	0.3	-1.9	-1.6	0.0	-0.3	-0.2	-0.4	1.4	-0.1	-1.0	-1.1	-1.2
Multivitamins +/- minerals	0.5	0.7	2.7	0.5	0.9	1.6	-0.7	0.7	-0.1	-0.5	-0.2	0.8	1.2	0.6	-0.1	1.6	-0.2	0.5	0.5	1.3	0.8
Stomach or abdominal pain in last month	1.1	1.4	4.8	-0.6	-1.4	-2.2	-1.2	-0.3	-0.1	0.8	-1.2	-1.4	-0.8	0.4	0.7	-2.0	0.9	1.1	0.1	-1.5	-1.6
Supplements: Glucosamine	0.6	0.8	3.3	-1.4	-0.8	-0.3	-0.2	-1.8	-1.8	0.1	0.2	-0.5	0.6	-1.1	-1.1	0.3	0.0	-0.7	-1.2	-0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	6.2	0.9	0.4	0.3	-0.1	1.4	1.0	1.9	0.9	-0.2	2.1	2.5	1.2	-0.1	0.9	2.5	1.8	0.5	0.7
Medication: Atenolol	0.9	1.2	5.2	1.4	-0.3	-1.8	-0.0	0.9	1.4	0.5	-0.3	-0.5	-0.5	-0.5	2.0	-2.3	-0.5	-0.8	0.3	-0.7	-1.1
Medication: Levothyroxine sodium	0.5	0.9	4.3	-0.0	-0.5	-0.5	-2.1	0.7	-0.3	0.9	-0.1	0.3	-1.7	0.5	-0.5	-0.0	1.4	1.3	0.2	1.7	0.8
Sitting height	2.6	18.4	48.3	-1.7	3.6	6.5	4.1	-2.9	-3.3	-2.6	1.7	5.7	3.4	-4.5	-5.2	7.0	-5.4	-4.7	-2.7	4.0	3.8
Chronic bronchitis/emphysema (father)	0.4	0.4	1.5	-0.1	-0.5	-0.7	-0.4	0.4	-0.2	0.6	-0.9	-0.9	-1.0	-0.3	0.3	-0.7	0.5	-0.6	-1.2	-0.9	-0.6
High blood pressure (mother)	1.9	2.7	6.7	-0.8	-2.1	-2.5	-1.1	-0.0	-0.3	1.5	-1.6	-2.6	-1.2	0.1	0.8	-2.1	2.6	0.4	-0.9	-1.6	-2.6
Body mass index (BMI)	0.7	3.0	9.1	-1.9	-0.1	1.5	0.8	-1.8	-2.1	-0.9	0.3	2.1	2.3	-0.8	-2.8	2.4	-2.2	0.2	0.3	0.7	3.0
Impedance of leg (left)	0.1	0.6	2.8	0.1	0.8	1.1	1.7	0.1	-0.1	-0.6	1.5	-0.1	0.6	1.3	-0.1	1.0	0.0	0.6	0.0	-0.5	-0.0
Leg predicted mass (left)	1.5	8.0	21.6	-1.1	2.1	4.0	1.7	-2.0	-1.6	-2.0	0.4	4.2	2.8	-3.0	-3.0	4.2	-4.7	-3.1	-0.9	2.8	3.0
Trunk fat mass	2.8	11.9	30.8	-2.3	1.7	4.6	2.5	-3.1	-3.2	-3.3	1.7	4.4	3.3	-2.2	-4.6	5.5	-5.3	-1.8	-0.6	1.8	4.7
Waist circumference	2.9	10.8	27.2	-2.0	1.6	4.4	2.7	-2.8	-2.9	-2.8	2.0	4.3	3.6	-1.8	-4.5	5.2	-4.7	-1.3	-0.1	2.0	4.7
Number of incorrect matches in round	0.5	0.8	2.4	-1.2	-1.5	-0.5	-0.3	-1.1	-1.1	0.4	-0.8	-0.5	-0.2	-1.2	-1.4	0.1	0.5	-0.7	-1.0	0.5	-0.6
Past tobacco smoking	0.4	0.7	2.7	-0.2	0.5	0.3	1.4	-0.8	-0.4	0.3	-0.7	0.7	1.3	-1.5	-0.5	0.3	-0.9	-1.6	-0.8	0.4	-0.1
Alcohol usually taken with meals	0.7	1.1	4.6	-0.6	-1.0	-1.1	0.4	-0.7	-1.1	-1.0	-1.5	-0.4	-0.8	-2.1	-0.6	-0.9	-0.4	-1.6	-1.5	-0.6	-1.0
Nervous feelings	1.1	2.1	7.3	-2.2	-0.8	0.6	1.4	-2.2	-2.5	-1.1	0.3	0.7	1.7	-1.0	-2.7	1.5	-0.4	0.3	-1.2	0.7	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.1	-0.5	-0.6	-0.6	0.0	-0.4	-0.4	-0.3	0.8	-0.2	-0.6	-1.5	-1.0	-0.3	-0.4	-1.2	-0.8	-0.2	-0.6
Hearing difficulty/problems with background noise	0.3	0.4	1.1	-0.8	-0.8	-0.4	-1.0	0.5	-1.0	0.5	-0.9	-0.2	-0.8	-0.5	-0.5	-0.1	0.4	0.1	0.1	-1.0	0.6
Hair/balding pattern: Pattern 2	3.1	4.0	9.1	0.4	-1.9	-3.0	-3.0	-0.0	1.0	2.1	0.2	-2.3	-2.9	1.5	1.8	-2.8	2.9	2.4	0.3	-0.8	-1.4
Had menopause	0.3	0.3	1.9	0.6	0.2	0.0	1.1	0.3	0.3	-0.5	-1.4	0.2	1.0	-0.1	0.6	-0.5	-0.4	-0.2	0.5	-0.2	0.4
Had other major operations	0.3	0.4	2.5	-0.6	-0.3	0.0	-0.6	-0.6	-0.3	1.6	-1.6	0.1	0.1	0.3	-0.4	0.3	-0.1	0.8	0.2	-0.1	0.1
Forced vital capacity (FVC)	1.6	6.1	21.4	0.7	3.2	3.7	3.0	-0.9	0.2	-1.9	2.0	3.2	2.3	-2.3	-1.0	2.9	-4.6	-3.4	-0.9	1.7	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.8	-1.7	0.1	0.4	0.4	-0.9	-1.5	-0.2	-0.4	-0.5	0.7	-0.5	-1.2	0.6	0.6	-0.3	-0.9	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.5	-0.3	-0.2	-0.2	-0.3	0.2	0.1	-0.2	0.9	-0.4	-0.5	1.1	0.2	-0.2	0.1	1.2	0.7	-1.2	0.5
Qualifications: None of the above	0.8	1.7	4.6	-2.0	-1.7	-1.2	0.7	-1.7	-2.2	-1.1	-0.5	-1.5	0.5	-1.0	-1.3	-0.5	0.5	-0.6	-1.4	-2.0	-1.1
Financial difficulties in last 2 years	0.8	1.0	2.2	1.4	0.8	0.3	-1.5	1.3	1.2	1.4	-0.8	1.2	-1.3	0.5	0.7	0.2	-0.5	0.3	1.0	1.5	0.5
Mouth/teeth dental problems	0.2	0.3	1.3	0.4	0.4	0.2	0.3	-0.4	-0.3	-1.1	-0.3	0.2	-0.6	-0.5	0.3	0.4	-0.4	-1.1	-0.7	0.6	-0.5
Heart attack	1.0	1.3	4.5	-1.0	-0.9	-0.5	0.3	-1.2	-1.1	-2.1	-2.1	-0.6	-0.1	-1.7	-1.2	-0.3	0.3	-1.1	-1.5	-0.3	-1.1
Allergy	1.0	2.2	10.2	2.0	1.9	1.1	1.0	0.7	1.2	-0.8	3.2	1.8	0.6	0.9	1.0	0.7	-1.8	0.4	1.6	1.4	1.9
Pain all over the body in last month	0.6	0.6	1.7	0.8	1.1	0.6	0.3	0.8	0.8	1.0	0.8	1.1	-0.3	0.3	-0.1	0.4	-0.6	0.6	0.6	1.3	1.1
Diabetes (self-reported)	1.0	1.6	4.5	-1.9	-0.5	0.5	1.4	-1.7	-2.1	-1.0	-0.1	0.2	1.9	-1.2	-1.7	1.0	-0.7	-0.8	-1.8	-0.3	0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.2	-1.5	-1.8	-1.3	-0.3	-1.2	-1.3	-0.2	-1.2	-2.0	-0.4	-0.9	-0.9	-1.0	1.7	-0.1	-1.8	-1.4	-1.7
Medication: Ramipril	0.2	0.3	0.8	-0.2	0.2	0.2	0.4	-0.3	-0.2	0.6	-0.4	0.7	0.7	-0.9	-0.6	0.2	-0.6	-0.6	-0.3	0.9	0.2
Medication: Simvastatin	1.7	2.5	6.5	-1.3	0.1	0.9	1.8	-1.7	-2.5	-1.4	-0.6	1.0	1.0	-2.5	-2.5	1.6	-1.2	-2.1	-1.9	0.5	1.1
Fluid intelligence score	0.4	0.8	4.0	0.3	1.1	1.3	1.1	-0.2	0.4	-2.0	0.5	0.7	1.0	0.1	0.9	1.0	-1.2	-0.7	0.2	0.7	0.7
Illnesses of siblings	0.2	0.3	0.9	0.0	-0.8	-0.9	0.0	-0.2	0.7	-0.2	-0.0	-0.2	-0.8	-0.3	-0.2	-0.9	0.0	0.3	0.4	-0.2	-0.7
Neuroticism score	1.5	3.2	8.0	-2.2	-0.8	0.0	2.1	-2.7	-2.8	-2.7	1.6	0.0	0.9	-2.2	-2.8	0.9	-0.6	-0.8	-2.5	-0.4	0.8
Weight	2.2	10.7	27.2	-1.9	1.9	4.5	2.5	-2.6	-2.7	-2.5	1.1	4.5	3.9	-2.4	-4.1	5.2	-4.9	-2.1	-0.6	2.3	4.3
Impedance of arm (right)	0.6	2.6	13.1	-1.7	0.2	1.1	1.1	-2.1	-2.0	-3.6	0.2	-0.1	-0.5	-1.7	-1.5	1.5	-1.1	-2.2	-2.3	-1.1	-0.8
Arm fat percentage (right)	1.6	6.1	15.7	-3.0	0.0	2.5	1.7	-3.1	-3.3	-2.6	0.6	2.3	2.8	-1.7	-4.0	3.6	-3.1	-0.8	-0.8	0.1	3.1
Trunk fat-free mass	1.0	5.7	14.2	-0.9	1.7	3.5	1.8	-1.2	-1.5	-0.7	0.0	3.5	3.3	-2.4	-2.8	3.8	-3.1	-2.3	-0.8	2.6	2.6
Hip circumference	3.1	13.2	37.0	-1.6	2.5	5.4	3.1	-2.5	-2.8	-2.4	2.2	4.9	4.4	-1.8	-4.3	6.1	-5.2	-1.7	-0.3	3.1	5.0
Time employed in main current job	0.9	1.0	3.6	1.1	-0.1	-0.6	-0.3	0.8	1.6	1.6	-1.0	-1.2	-0.7	0.8	1.9	-1.1	1.1	0.2	0.3	-0.4	-1.1
Alcohol intake versus 10 years previously	0.8	1.2	4.6	0.1	1.5	1.8	1.1	0.5	0.1	-1.0	2.1	1.5	0.6	0.1	-0.3	1.4	-1.1	-0.6	0.8	0.6	1.0
Father’s age at death	2.9	3.9	9.3	-1.9	-3.1	-2.6	-1.6	-2.0	-1.8	-1.4	-2.2	-2.0	-2.4	-2.3	-1.7	-1.7	2.2	-0.9	-1.5	-1.5	-1.8
Worrier / anxious feelings	2.1	3.9	9.6	-2.8	-2.4	-1.8	0.4	-2.8	-3.1	-2.1	0.0	-2.2	-0.3	-2.1	-2.1	-0.7	1.4	-0.9	-3.1	-1.9	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	-0.9	-0.0	1.0	-0.3	-0.8	-1.3	-0.2	1.2	1.1	0.9	-0.4	-1.3	1.5	-1.0	-0.0	-0.5	1.0	0.8
Falls in the last year	1.6	2.2	6.7	-1.9	-0.6	0.2	0.4	-1.7	-2.1	-1.7	-0.4	-0.1	-0.9	-2.4	-2.3	0.8	-0.8	-2.1	-2.6	-0.8	0.2
Hair/balding pattern: Pattern 3	0.6	0.8	3.2	-1.2	-0.9	-0.3	0.2	-1.8	-1.6	-0.8	-0.1	-0.2	0.3	-1.1	-1.5	0.3	0.3	-0.5	-1.2	-0.7	-0.6
Number of live births	0.3	0.4	2.0	-0.1	-0.1	-0.5	0.3	-0.3	-0.4	1.2	-0.4	1.0	0.1	0.1	0.0	-0.1	-0.8	0.4	0.6	1.1	1.4
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	33.5	1.7	4.1	4.5	2.8	-0.4	1.0	-1.5	2.8	4.1	2.7	-1.6	-0.4	3.5	-5.8	-3.0	0.2	2.8	2.0
Pulse rate	0.8	1.4	7.6	-0.3	-0.6	-0.2	-1.0	0.6	0.5	1.5	0.3	-0.6	0.9	2.4	0.5	-0.1	1.8	2.8	1.7	-0.1	0.5
Happiness	0.7	0.8	2.3	1.4	1.5	0.6	0.1	0.8	1.5	0.9	1.3	0.5	0.4	0.9	1.5	-0.0	-0.5	0.3	0.8	0.5	0.3
Noisy workplace	0.4	0.4	1.3	-0.4	-1.1	-1.1	-0.3	-0.4	-0.7	0.6	0.4	-0.7	-0.0	-0.1	-0.9	-0.6	1.0	0.9	-0.7	-0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.4	-1.0	0.3	1.1	-0.3	0.1	-0.8	1.6	-0.8	-0.3	0.6	0.0	-0.6	1.2	0.5	-0.1	-0.7	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.6	-0.8	-0.4	0.2	-0.9	-0.3	-0.8	0.8	-1.6	-0.4	-0.1	-0.5	-0.4	0.6	0.8	-0.8	-0.8	0.2	-0.9
Mouth/teeth dental problems: Dentures	1.3	2.3	5.8	1.0	1.5	1.6	0.9	1.6	1.5	1.8	0.5	1.2	1.6	2.4	0.7	0.8	-0.4	2.2	2.2	0.3	2.2
Asthma	1.2	2.4	9.2	-2.6	-1.8	-0.5	-1.3	-1.6	-1.9	0.5	-3.0	-0.9	-1.1	-1.8	-2.1	0.1	1.1	-1.0	-1.6	-0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	5.5	0.4	1.3	1.5	0.2	0.5	-0.3	0.6	1.9	1.4	0.2	0.9	-0.8	1.7	-0.5	1.2	0.2	2.3	1.8
Medication: Cholesterol lowering	0.4	0.6	2.8	-0.6	-0.2	0.2	0.0	-1.1	-1.2	-0.9	-1.7	0.3	-0.0	-0.8	-1.0	0.6	-0.6	-0.6	-0.5	0.6	0.6
Depression (self-reported)	1.0	1.1	3.8	0.2	1.5	1.5	0.8	0.1	0.5	-0.7	2.0	1.2	0.8	1.0	0.0	1.2	-0.8	0.7	1.0	1.1	1.7
Medication: Lansoprazole	0.9	1.0	4.3	-0.4	0.3	0.0	-1.0	1.3	-0.2	1.9	-2.1	-1.1	0.7	1.0	0.9	-0.1	1.4	0.5	-0.1	-0.8	-0.4
Prospective memory result	1.6	1.9	5.9	0.3	-2.0	-2.4	-1.8	0.6	0.8	0.5	1.3	-1.3	-1.6	0.9	0.7	-2.0	1.9	1.9	0.8	-0.5	-0.7
Lung cancer (father)	0.5	0.6	2.8	-0.0	0.5	0.3	1.6	0.3	0.5	0.3	0.6	0.4	1.5	-0.2	0.4	-0.2	-1.7	-0.6	0.4	-0.7	0.3
Illnesses of mother	1.7	2.2	7.5	1.8	2.2	1.4	1.1	0.5	1.1	-1.2	2.7	2.2	0.2	0.4	0.3	0.8	-1.8	0.5	1.3	1.6	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.5	22.8	1.8	3.9	4.4	2.6	-0.0	1.1	-1.2	3.1	3.8	2.3	-1.2	-0.3	3.5	-4.8	-2.6	0.3	3.1	2.3
Pulse wave Arterial Stiffness index	2.0	2.3	10.8	1.3	1.5	1.3	1.4	0.6	1.0	0.1	3.3	1.7	1.7	1.5	-0.0	0.8	-1.7	1.1	2.1	0.2	2.1
Impedance of arm (left)	0.5	2.4	9.7	-1.0	1.0	1.4	1.5	-1.8	-1.4	-3.1	1.4	0.2	-0.6	-1.8	-1.1	1.3	-1.9	-2.4	-2.0	-0.9	-0.4
Arm fat mass (right)	1.9	7.6	18.8	-2.5	0.7	3.3	1.7	-2.8	-3.1	-2.2	0.8	3.3	3.2	-1.9	-4.2	4.3	-3.9	-1.1	-0.6	1.1	3.9
Trunk predicted mass	1.0	5.6	13.7	-0.9	1.7	3.5	1.8	-1.2	-1.4	-0.7	0.1	3.5	3.4	-2.4	-2.7	3.7	-3.1	-2.3	-0.8	2.6	2.5
Standing height	1.7	17.3	45.3	-0.7	4.3	6.7	4.0	-2.3	-1.9	-3.4	1.8	5.5	3.7	-3.7	-3.7	6.7	-6.2	-5.0	-1.9	3.7	3.4
Length of working week for main job	2.0	2.2	8.9	1.0	1.0	0.0	-1.4	1.7	1.7	1.8	1.2	-0.5	-0.3	3.0	2.1	-0.4	0.8	2.5	1.8	0.6	0.3
Exposure to tobacco smoke at home	0.3	0.4	1.4	0.7	0.8	0.4	0.5	0.8	0.9	0.5	0.5	-0.2	0.5	0.6	1.2	-0.3	-0.6	0.0	0.8	-0.7	0.4
Breastfed as a baby	1.1	1.4	4.1	2.0	1.1	0.5	0.5	1.9	2.0	-0.2	-0.8	-0.1	0.1	1.7	2.0	-0.4	0.1	0.1	1.6	-0.6	0.4
Tense / ‘highly strung’	0.8	1.2	4.0	-1.1	-0.9	-0.5	0.6	-1.1	-1.3	-2.0	0.4	-0.1	-0.4	-2.0	-1.8	-0.2	-0.6	-1.2	-1.7	-0.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.4	-1.5	-1.8	-1.0	-1.8	-1.2	-1.1	-0.2	0.5	-1.0	-1.6	0.5	-1.6	-0.2	1.7	1.7	0.2	-0.5	0.0
Hair/balding pattern: Pattern 4	0.3	0.8	3.2	-0.5	-0.7	-0.6	-0.2	0.7	0.4	0.6	-0.0	-1.3	-0.1	1.1	0.3	-0.9	1.7	1.8	1.1	-0.8	0.2
Birth weight of first child	1.1	2.0	8.3	-1.3	-0.9	-0.6	0.1	-1.3	-1.6	-0.3	-2.0	-0.4	-1.0	-2.9	-1.2	-0.1	-1.0	-2.8	-1.9	-1.1	-1.1
Peak expiratory flow (PEF)	1.5	3.5	19.3	1.4	2.3	2.7	1.9	-0.2	0.8	0.1	1.3	2.7	1.7	-0.9	-0.1	2.2	-4.4	-2.2	0.3	1.5	0.9
Pulse wave reflection index	1.3	1.6	7.2	1.2	1.7	1.1	2.1	0.6	1.0	-0.1	2.7	1.3	1.0	-0.2	0.5	0.4	-2.2	-1.1	0.9	0.3	1.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.7	-1.9	-1.2	-0.2	-0.1	-1.0	-1.6	-0.1	-0.4	-0.6	0.1	-0.3	-1.7	0.3	0.6	0.7	-1.1	-1.3	-0.4
Loud music exposure frequency	0.6	0.7	2.0	-0.8	-1.4	-1.2	-1.0	-1.2	-0.6	-0.8	0.0	-0.9	-0.5	0.1	-0.5	-0.5	1.1	0.9	-0.7	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.3	1.0	1.0	0.1	-1.5	1.1	1.4	0.1	-1.2	-0.1	-0.8	0.0	1.2	-0.4	-0.0	-0.5	-0.2	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.1	-0.8	-1.2	-1.0	-0.9	-1.0	-0.6	-0.4	-0.2	-0.9	-0.1	-1.5	-0.4	-0.7	-0.2	-0.9	-0.9	-0.9	-0.9
Blood clot in the leg (DVT)	0.1	0.1	0.7	0.0	0.3	-0.2	0.2	0.4	-0.3	0.1	-0.8	0.1	0.7	0.4	0.1	0.0	0.2	0.5	0.1	-0.3	0.3
Medication: Paracetamol	0.5	0.8	3.1	-0.7	-1.5	-1.3	-1.1	-0.5	-0.7	-0.4	-0.2	-1.0	-1.8	0.0	-0.2	-0.7	1.0	0.5	-0.6	-0.8	-0.5
Headache pain in last month	0.3	0.5	1.3	0.8	0.1	-0.7	-0.5	0.2	0.9	0.5	-0.6	0.1	-1.1	-0.6	1.0	-1.0	-1.1	-0.7	0.4	-0.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.6	0.8	0.5	0.1	-0.2	1.4	1.8	1.6	1.3	-0.1	0.3	1.9	1.1	-0.5	1.0	1.8	1.5	-0.4	-0.1
Glaucoma (self-reported)	1.0	1.2	5.3	-0.1	0.6	1.4	0.7	-0.3	-0.4	-2.3	1.8	1.0	-0.2	-0.6	-1.2	1.5	-0.8	-1.1	-0.7	0.5	1.3
Gout (self-reported)	0.3	0.4	1.7	0.4	-0.1	-0.2	-0.5	-0.4	0.2	-1.0	-1.0	0.1	-0.7	-0.9	0.6	-0.2	-0.8	-1.3	-0.9	0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.5	-1.0	-1.3	-1.1	-1.9	-0.3	-1.0	0.1	-0.8	-0.4	-1.1	-0.2	-1.0	-0.3	1.4	0.7	-0.4	0.4	0.1
Medication: Amlodipine	3.7	5.2	13.2	-2.7	-3.6	-2.9	-1.8	-2.7	-2.6	-1.6	-2.9	-2.4	-2.4	-2.2	-1.4	-1.6	1.5	-1.1	-2.1	-2.1	-1.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.9	-0.7	-0.8	0.4	-0.4	-0.3	-0.7	0.8	-1.4	0.0	0.0	-0.0	-0.6	0.9	0.5	-0.7	0.1	-0.3	-0.0
Birth weight	1.1	2.4	4.6	-1.5	0.3	1.9	1.6	-2.1	-1.6	-1.5	-1.2	0.9	1.8	-1.4	-2.1	2.2	-1.7	-1.4	-1.8	-0.4	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.5	-0.6	-0.2	0.5	0.7	0.2	-0.5	1.2	-0.5	0.2	0.5	0.1	-0.9	0.9	0.3	-0.3	-0.0	0.5	0.3
High blood pressure (siblings)	0.1	0.2	1.0	-0.4	-0.3	-0.3	-0.5	0.0	-0.6	0.2	-0.2	-0.3	0.3	-0.6	0.0	-0.1	0.7	-1.0	-0.6	0.4	0.0
Forced vital capacity (FVC), Best measure	1.7	6.2	17.8	0.9	3.3	4.1	2.6	-0.6	0.3	-1.8	2.2	3.2	1.9	-2.0	-1.0	3.4	-4.2	-3.2	-0.7	2.4	1.6
Body fat percentage	2.1	8.4	21.5	-2.5	0.9	3.5	2.2	-3.0	-3.2	-2.9	1.5	3.4	3.0	-1.4	-4.2	4.6	-4.1	-0.7	-0.3	0.9	4.2
Leg fat percentage (right)	1.6	5.8	14.4	-2.5	0.2	2.5	1.9	-2.7	-2.9	-1.7	1.7	2.5	3.1	-0.5	-3.8	3.6	-2.9	0.6	0.1	0.6	3.8
Arm fat-free mass (right)	1.1	5.7	16.1	0.2	2.3	3.7	1.6	-0.5	-0.3	-0.4	0.9	4.0	3.1	-1.5	-1.8	3.5	-3.8	-1.8	0.3	3.1	3.1
Exposure to tobacco smoke outside home	2.4	3.2	10.8	-1.7	-2.3	-2.2	-2.8	-1.0	-1.0	0.2	-1.1	-2.2	-1.6	0.8	-0.3	-1.5	3.3	1.7	0.4	-1.6	-2.4
Comparative body size at age 10	0.2	0.6	2.3	0.8	-0.1	-0.7	-1.1	0.4	0.8	1.5	-1.0	-0.1	-1.4	-0.3	0.6	-0.6	0.6	-0.3	-0.4	1.3	-0.2
Number of full brothers	0.3	0.3	1.4	-0.1	0.6	0.1	0.7	-0.6	-0.0	-1.2	0.3	0.2	0.9	-0.9	-0.2	0.1	-0.2	-0.9	-0.7	-0.1	-0.5
Worry too long after embarrassment	0.8	1.4	5.0	-1.0	-0.6	-0.1	1.6	-1.8	-1.4	-2.2	0.2	-0.3	-0.3	-2.0	-1.4	0.1	-0.3	-1.2	-1.6	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.9	-0.7	-0.7	0.3	-1.0	-0.4	-0.3	0.8	1.7	0.1	-0.1	0.9	-1.1	0.8	0.3	1.6	0.8	0.5	1.2
Wheeze or whistling in the chest in last year	2.1	3.7	9.3	-3.0	-2.9	-1.7	-1.8	-1.7	-2.5	-0.4	-3.0	-1.7	-1.2	-1.3	-2.4	-0.7	2.3	0.3	-1.6	-2.0	-0.9
Number of children fathered	0.5	0.5	1.9	0.3	0.5	-0.4	1.2	0.3	0.4	0.8	0.7	-0.3	1.2	0.9	0.5	-0.6	0.2	1.4	0.7	-0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	6.7	0.1	0.5	0.2	0.9	-1.6	-0.3	-2.4	2.6	0.5	-0.7	-1.7	-0.8	0.1	-1.4	-1.5	-0.9	0.3	0.4
Age at first live birth	0.8	1.4	6.2	-0.9	0.5	0.9	-0.1	-0.8	-0.6	0.3	-1.0	0.5	-1.2	-2.5	-1.5	0.8	-1.1	-2.4	-1.8	-0.2	-0.6
Pulse wave peak to peak time	1.7	2.0	10.9	-1.4	-1.1	-0.7	-1.3	-0.6	-1.2	-0.4	-3.3	-1.3	-1.4	-1.6	-0.3	-0.2	1.5	-1.2	-2.1	0.1	-1.7
Health satisfaction	1.2	1.5	5.4	-1.8	-1.5	-0.3	0.1	-2.3	-2.3	-1.3	0.6	-0.2	0.3	-0.9	-2.2	0.7	-0.1	0.3	-1.7	-0.3	0.3
Shortness of breath walking on level ground	1.1	1.3	5.6	-1.1	-1.6	-0.9	-1.0	-1.0	-1.0	-2.4	0.2	-0.7	-1.7	-1.4	-1.0	-0.6	0.2	-1.2	-1.0	-1.2	-0.5
Qualifications: College or University degree	0.2	0.7	2.8	-0.3	0.3	1.2	-0.1	0.2	0.3	1.7	-0.2	0.5	0.2	1.2	-0.5	1.2	0.2	1.4	0.4	0.8	1.2
Eye problems/disorders: None of the above	1.2	1.4	6.2	1.3	0.2	-0.7	-0.9	2.5	1.3	1.9	-0.2	0.6	0.7	1.0	1.2	-0.8	0.4	1.5	1.5	1.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.6	0.9	-0.2	-0.5	0.2	1.6	1.2	1.4	1.4	-0.4	0.5	0.6	0.4	-0.9	0.9	1.1	0.5	0.8	-0.2
Emphysema/chronic bronchitis	0.3	0.4	2.9	0.4	-0.4	-0.6	-1.0	0.3	0.3	0.1	-0.4	0.4	-1.7	-0.4	-0.3	-0.6	0.2	-0.2	0.5	0.5	-0.7
Medication for pain relief, constipation, heartburn	0.8	1.3	3.3	1.5	1.8	1.1	0.9	0.7	1.4	-0.9	0.7	1.4	1.2	-0.3	1.2	0.4	-1.7	-1.3	1.5	0.3	0.1
Neck or shoulder pain in last month	1.5	2.1	4.6	-1.8	-2.1	-1.6	-1.7	-1.3	-1.8	-1.7	-0.8	-1.3	-1.6	-1.6	-1.7	-0.7	1.3	-0.5	-1.9	-0.9	-0.7
Medication: Blood pressure	0.7	1.2	3.6	-0.3	-0.1	0.5	0.6	-1.1	-1.5	-0.9	-0.8	0.9	-0.3	-1.9	-1.4	1.1	-1.4	-1.9	-1.3	0.8	0.8
Angina (self-reported)	0.9	1.2	3.3	-1.2	-1.0	-0.7	-0.6	-1.4	-1.4	-1.8	-1.2	-0.5	-0.9	-1.8	-1.2	-0.3	-0.4	-1.2	-1.4	-0.8	-0.4
Migraine (self-reported)	0.4	0.5	2.1	-0.3	0.5	0.7	1.1	-0.7	-0.5	0.2	1.0	0.4	1.5	0.3	-0.9	0.9	0.5	0.6	-0.4	0.8	-0.1
Medication: Ibuprofen	1.8	2.1	7.1	0.6	2.1	2.2	1.0	0.4	-0.2	-0.4	2.4	1.7	0.4	0.5	-0.9	2.2	-1.2	0.4	-0.0	2.7	2.0
Medication: Allopurinol	0.7	0.9	2.8	-0.5	-0.7	-0.5	-0.6	-1.0	-0.4	-1.6	-1.6	-0.1	-0.5	-1.6	-0.1	-0.4	-1.0	-1.7	-1.1	-0.8	-0.3
Medication: Omeprazole	2.0	2.4	6.8	-0.5	-1.7	-2.2	-1.5	0.8	0.2	1.8	-2.6	-2.0	-1.2	-0.1	0.9	-2.4	2.4	0.3	-0.6	-1.3	-1.8
Medication: Seretide 50 evohaler	0.6	0.6	5.4	-0.6	-0.9	-0.2	-2.3	0.1	-0.2	0.2	-1.0	-0.8	-0.6	0.2	0.2	-0.1	1.5	0.3	-0.3	0.0	-0.7
Mean time to correctly identify matches	0.6	1.1	3.0	1.6	0.4	-0.8	0.1	0.9	1.3	-0.8	1.2	0.1	0.0	1.7	1.6	-1.0	-0.2	1.5	1.7	-0.1	0.5
Heart disease (mother)	2.1	2.5	7.3	-0.9	-1.9	-2.1	-1.1	-0.6	-0.7	-1.5	-1.8	-2.0	-1.1	-1.8	-0.1	-1.8	1.0	-1.7	-2.0	-1.5	-2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.4	-0.1	-1.4	-1.4	-0.0	0.7	0.1	1.8	-1.4	-0.9	-0.2	0.4	0.3	-1.2	1.2	0.8	-0.2	-0.7	-0.8
Whole body fat mass	2.5	10.5	27.7	-2.4	1.4	4.2	2.5	-2.9	-3.1	-2.8	1.8	4.1	3.6	-1.8	-4.5	5.3	-4.6	-1.2	-0.3	1.7	4.6
Leg fat mass (right)	2.1	8.1	20.9	-2.2	1.1	3.7	2.1	-2.5	-2.7	-2.0	1.8	3.7	3.4	-1.1	-4.1	4.6	-3.9	-0.3	0.1	1.7	4.4
Arm predicted mass (right)	1.1	5.5	14.6	-0.0	2.1	3.5	1.7	-0.6	-0.6	-0.2	0.6	3.8	3.2	-1.5	-1.9	3.5	-3.6	-1.7	0.2	2.9	3.1
Pulse rate, automated reading	0.6	1.9	9.2	-0.7	-1.9	-1.1	-1.2	0.1	0.2	2.1	-0.3	-1.6	-0.5	1.6	0.1	-1.0	3.0	2.6	0.5	-0.5	-0.2
Alcohol intake frequency.	0.4	0.9	4.5	1.0	0.3	0.1	0.1	0.8	1.0	1.0	2.1	0.8	0.5	1.0	0.4	-0.1	-0.0	0.9	1.7	1.3	0.2
Comparative height size at age 10	1.2	6.7	18.6	-0.1	2.2	3.8	2.5	-1.5	-1.4	-2.2	0.8	3.2	1.4	-2.8	-2.6	3.9	-4.3	-3.6	-1.4	2.4	2.0
Number of full sisters	0.4	0.5	1.8	0.5	-0.3	-0.7	-1.1	0.6	0.6	-0.2	-0.1	-0.2	-0.2	1.3	0.4	-0.6	0.4	1.2	1.1	0.1	-0.6
Suffer from ‘nerves’	0.7	1.1	6.2	-0.4	-1.5	-1.6	-0.2	-0.8	-0.3	0.2	1.4	-0.8	-0.8	1.0	-0.6	-1.0	1.5	2.5	0.4	-0.1	0.5
Overall health rating	0.3	0.6	2.1	-1.1	-1.4	-0.8	-0.8	-0.8	-1.1	0.2	-0.3	-0.3	-0.4	-0.5	-1.4	-0.4	0.0	1.0	-0.8	-0.4	0.3
Chest pain or discomfort	0.4	0.5	1.5	-0.1	-0.9	-0.9	-1.1	0.9	-0.1	1.2	-0.8	-0.6	-1.1	-0.3	0.4	-0.7	0.8	-0.1	-0.1	-0.3	-0.5
Had major operations	1.6	1.9	7.2	-2.2	-2.0	-1.3	-0.9	-0.9	-1.3	0.3	-1.8	-1.4	-1.1	0.1	-1.6	-0.7	2.7	1.1	-0.4	-1.6	-1.0
Age at last live birth	0.6	0.8	3.1	-1.1	-0.5	-0.2	-1.1	-1.1	-0.5	0.6	-1.2	0.1	-1.8	-1.4	-1.0	-0.0	-0.5	-1.0	-1.0	-0.1	-0.8
Family relationship satisfaction	0.6	0.7	3.6	0.9	1.9	1.5	0.5	0.0	0.6	-0.3	0.6	0.8	-0.2	-0.2	0.3	1.1	-0.7	-0.8	-0.4	1.2	0.4
Leg pain on walking	0.5	0.7	2.6	-1.2	-0.9	0.1	-0.3	-0.7	-1.6	-0.0	-0.6	-0.9	0.6	0.0	-1.1	0.7	1.0	0.1	-1.3	-0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.7	1.5	0.7	-0.1	-1.6	1.5	1.4	1.7	0.6	0.9	-1.8	0.7	0.9	-0.3	0.2	0.5	1.9	1.3	0.6
Commuting to job workplace: Car/motor vehicle	1.7	2.0	4.9	0.5	1.6	2.2	-0.5	0.9	1.1	1.3	0.1	1.9	1.0	1.6	0.2	1.8	-1.3	1.3	1.8	1.6	2.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.6	-0.0	0.1	-0.3	0.9	0.4	0.1	-1.0	1.0	-0.4	0.7	0.6	0.7	-0.6	0.2	0.5	0.7	-1.3	0.3
Medication: Aspirin	0.7	0.9	3.0	-1.5	-0.9	-0.2	-0.1	-1.2	-1.7	-0.1	-1.3	-1.1	0.4	0.1	-1.3	0.4	0.9	0.7	-1.3	-0.4	0.2
Supplements: Vitamin C	0.4	0.5	2.2	-0.1	0.5	0.5	0.6	-0.5	-0.7	-1.5	1.1	0.7	0.4	-0.4	-0.8	0.7	-1.0	-0.5	-0.2	0.1	0.4
Knee pain experienced in last month	1.1	1.7	6.0	-2.4	-0.6	0.9	-0.1	-2.0	-2.5	-0.4	-0.7	0.4	1.4	-1.0	-2.2	1.7	-0.3	-0.4	-1.1	0.1	0.5
Hypertension (Self-reported)	0.4	1.0	4.0	-0.6	-1.3	-0.7	-0.6	-1.2	-1.4	-0.6	-0.8	-0.0	-1.2	-2.0	-0.9	-0.0	-0.7	-1.8	-1.1	-0.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	6.5	-1.0	-1.9	-1.9	-1.8	-0.2	-0.4	0.3	-2.3	-2.2	-1.4	-0.1	0.4	-1.6	2.6	0.4	-0.8	-1.9	-1.6
Illnesses of father: Heart disease	0.7	1.0	5.2	-0.5	-0.7	-1.6	-0.6	-0.5	-0.0	-0.5	-2.3	-1.2	-0.2	-0.5	0.8	-1.4	0.6	-0.2	-0.6	-1.3	-1.2
Illnesses of siblings: Diabetes	0.1	0.1	0.8	-0.3	0.1	0.1	-0.1	-0.2	-0.2	-0.4	-0.9	-0.2	0.1	-0.0	0.1	0.1	-0.1	-0.2	-0.4	-0.3	-0.3
Smoking status: Previous	0.2	0.3	2.1	-0.1	-0.5	-0.2	-1.2	0.0	-0.3	-0.4	0.2	-0.6	-1.4	0.1	-0.2	-0.0	0.5	0.5	-0.4	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	9.4	-0.1	2.4	3.0	2.0	-1.0	-0.9	-1.8	1.2	2.9	2.0	-1.9	-1.6	3.1	-3.0	-2.5	-0.9	1.6	1.2
Whole body fat-free mass	1.2	7.0	16.7	-1.0	2.0	3.9	1.9	-1.5	-1.4	-1.2	0.2	4.0	3.3	-2.6	-2.9	4.1	-3.9	-2.7	-0.8	2.8	2.9
Leg fat-free mass (right)	1.4	7.3	20.5	-0.6	2.3	3.9	1.8	-1.4	-1.1	-1.9	0.5	4.2	2.9	-2.6	-2.4	4.0	-4.5	-3.0	-0.6	2.7	2.9
Arm fat percentage (left)	1.6	6.3	14.8	-2.7	0.4	2.7	1.8	-3.0	-3.1	-2.5	1.2	2.5	2.8	-1.7	-3.9	3.6	-3.5	-0.9	-0.8	0.3	3.3
Average weekly red wine intake	0.3	0.4	1.6	-0.7	-0.2	0.4	1.0	-0.9	-0.8	0.3	0.6	0.3	-0.3	-0.4	-1.3	0.7	-0.3	0.2	-0.3	-0.4	1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.5	1.4	1.6	1.5	0.1	0.8	1.0	-0.3	-0.1	1.6	0.1	0.8	1.1	1.1	-0.9	-0.0	1.4	1.3	1.5
Mood swings	0.4	0.8	3.0	-1.2	-0.1	0.2	1.2	-0.8	-1.3	-0.8	1.7	0.1	0.4	-1.0	-1.3	0.5	-0.2	-0.5	-0.9	-0.3	0.7
Loneliness, isolation	1.0	1.4	3.9	0.4	1.3	1.3	0.7	0.0	-0.1	0.2	2.0	1.6	1.4	0.1	-0.9	1.4	-1.6	0.2	0.7	1.5	1.9
Long-standing illness, disability or infirmity	0.8	1.2	5.7	-1.0	-1.1	0.7	-0.8	-0.7	-1.6	0.3	0.7	0.9	-0.1	-0.3	-2.4	1.6	-0.0	0.7	-0.4	1.2	1.6
Ever had bowel cancer screening	0.5	0.5	2.3	-0.5	-0.9	-0.8	-0.1	-0.0	-0.5	1.5	-1.1	-0.8	-0.2	-0.5	-0.7	-0.9	0.4	0.5	0.1	-1.3	-0.2
Diabetes diagnosed by doctor	1.3	2.1	6.7	-1.7	-0.1	1.4	1.8	-1.5	-1.9	-0.8	-0.2	1.1	2.6	-1.2	-2.1	1.9	-1.2	-0.9	-1.2	0.4	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	4.2	-1.9	-0.7	0.1	-0.5	-1.9	-1.7	-1.0	-1.0	-0.4	-0.3	-0.5	-2.0	0.7	-0.1	0.3	-1.2	-1.0	0.1
Friendships satisfaction	0.8	1.0	2.3	1.2	1.5	1.3	-0.1	0.5	1.3	-0.2	0.5	1.3	1.0	0.7	0.9	0.7	-1.4	-0.2	1.1	1.3	0.9
Qualifications: nursing, teaching	1.1	1.6	5.8	-1.7	-2.0	-0.8	-1.3	-1.7	-1.5	-0.7	-1.1	-0.6	-0.6	0.6	-1.9	0.2	1.5	2.4	-0.3	-0.1	0.6
Commuting to job workplace: Walk	1.1	1.1	4.2	1.6	0.1	-1.3	-0.2	1.4	1.7	0.9	0.3	-0.8	0.1	0.7	2.0	-2.0	0.2	0.4	0.7	-0.5	-0.8
Eye problems/disorders: Cataract	1.1	1.2	4.1	-1.7	-0.6	-0.1	1.2	-2.0	-1.4	-1.3	0.1	-0.4	0.8	-1.4	-1.6	0.2	-0.6	-0.9	-1.1	-1.2	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.7	2.8	8.3	-1.8	-2.1	-2.1	-2.6	-0.9	-1.3	0.4	-0.6	-2.0	-2.4	-0.4	-1.1	-1.5	2.9	1.2	-1.3	-0.8	-1.4
Medication for cholesterol	0.3	0.5	3.5	-0.6	0.6	1.0	0.3	-0.5	-0.1	0.3	-1.9	-0.1	1.0	0.5	-0.2	1.1	-0.1	0.2	-0.3	0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.3	-1.1	-0.6	-0.4	-0.3	-0.1	-0.5	0.6	-0.7	-0.2	0.2	0.2	-1.0	-0.2	-0.1	1.1	-0.3	-0.1	-0.5
Back pain experienced in last month	2.1	3.0	9.6	-1.5	0.5	1.8	0.8	-1.9	-2.2	-2.4	0.4	1.5	0.8	-1.9	-3.1	2.4	-1.9	-1.4	-1.1	0.6	2.2
Mineral and other dietary supplements	1.3	1.7	8.1	2.0	1.0	0.0	-0.4	2.3	2.8	0.3	0.6	0.4	-0.8	1.2	2.4	-0.9	0.2	0.3	1.8	0.4	-0.0
Breast cancer (self-reported)	0.6	0.8	3.1	-0.6	0.6	1.4	0.3	-0.6	-0.6	-1.1	-0.2	0.8	0.1	-0.5	-1.4	1.7	-0.2	-0.6	-1.0	1.2	0.5
Asthma (self-reported)	1.6	3.1	13.0	-2.8	-2.2	-0.7	-1.8	-1.6	-2.0	0.8	-3.6	-1.3	-1.2	-1.7	-2.1	-0.0	1.6	-0.9	-1.8	-0.6	-1.4
Osteoporosis (self-reported)	0.4	0.5	2.3	0.3	0.3	0.9	-0.6	0.6	0.1	0.5	0.8	0.6	0.2	1.0	-0.2	1.0	0.3	0.6	0.8	1.5	1.1
Osteoarthritis (self-reported)	1.5	2.0	5.1	-1.9	-2.2	-1.2	-1.8	-1.3	-1.3	-1.1	-1.5	-1.9	-1.5	-0.7	-0.7	-0.6	1.8	-0.1	-1.2	-1.3	-1.3
Medication: Aspirin	0.5	0.7	2.5	-1.3	-0.5	0.3	0.3	-1.1	-1.6	-0.2	-1.2	-0.8	0.8	0.2	-1.0	0.8	0.2	0.2	-1.2	-0.5	0.4
Medication: Gliclazide	1.3	1.5	4.6	-2.2	-0.4	0.6	0.9	-2.0	-2.0	-1.1	1.2	0.2	1.0	-1.0	-2.0	1.1	-0.4	-0.7	-0.9	-0.6	1.1
Illnesses of father: None of the above (group 1)	1.3	1.6	7.4	-2.1	-0.8	0.6	0.3	-2.4	-2.2	-0.5	1.3	0.2	0.7	-0.4	-2.7	1.2	0.5	0.6	-0.9	0.5	0.3
Smoking status: Current	0.3	0.5	2.4	-0.1	-0.4	-0.3	-0.5	0.6	0.3	-0.2	0.0	-0.6	0.5	1.5	0.5	-0.4	1.3	1.3	1.0	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	11.1	1.2	2.3	2.3	1.6	0.1	0.3	-0.8	2.0	2.3	2.1	-0.5	-0.0	1.9	-3.3	-1.3	0.3	1.4	1.0
Whole body water mass	1.3	7.2	17.2	-0.9	2.0	3.9	2.0	-1.4	-1.4	-1.3	0.2	4.0	3.3	-2.6	-2.9	4.2	-4.0	-2.7	-0.7	2.9	2.9
Leg predicted mass (right)	1.4	7.3	20.2	-0.6	2.3	3.9	1.8	-1.4	-1.1	-1.8	0.4	4.2	2.8	-2.6	-2.5	4.0	-4.5	-3.0	-0.6	2.8	2.9
Arm fat mass (left)	1.9	7.7	19.3	-2.3	1.0	3.5	1.9	-2.6	-2.8	-2.2	1.2	3.5	3.3	-1.6	-4.0	4.4	-3.9	-0.9	-0.3	1.4	4.0
Number of self-reported non-cancer illnesses	3.2	5.6	15.8	-3.6	-2.9	-0.9	-0.4	-3.2	-4.0	-1.6	-3.0	-1.1	-0.6	-3.1	-3.6	0.4	0.7	-1.5	-3.5	-1.1	-0.6
Average weekly champagne plus white wine intake	1.5	2.0	5.5	-1.7	-2.3	-1.9	-1.4	-1.2	-1.0	0.1	-1.1	-2.4	-0.9	-0.0	-0.3	-1.4	1.9	0.5	-0.5	-2.2	-1.4
Miserableness	0.2	0.4	1.1	-1.0	-0.3	-0.1	0.7	-1.1	-1.0	-0.2	0.5	-0.5	0.9	-0.3	-0.7	0.3	0.5	0.5	-1.0	0.1	0.2
Guilty feelings	2.2	3.3	9.0	-2.2	-2.4	-1.7	0.0	-1.9	-2.6	-1.3	-0.3	-1.8	-0.9	-2.7	-2.0	-1.0	1.1	-1.4	-3.0	-1.7	-1.2
Wears glasses or contact lenses	0.9	1.1	4.0	-0.8	-1.9	-1.5	-0.3	-0.5	-0.2	0.1	-0.3	-1.8	0.1	0.6	-0.0	-1.2	2.0	0.8	-0.4	-0.9	-1.2
Ever taken oral contraceptive pill	1.1	1.2	3.8	0.7	1.6	2.0	1.2	0.2	0.4	-0.6	1.0	1.3	1.1	1.1	0.1	1.7	-1.3	0.6	0.5	1.0	1.4
Hearing aid user	2.0	2.2	6.4	-0.2	-2.1	-2.3	-2.3	0.4	0.1	-0.5	-1.2	-1.5	-2.5	-0.2	0.5	-2.1	2.0	0.4	0.2	-1.7	-1.6
Mother’s age at death	1.8	2.2	5.9	-2.4	-1.3	-0.3	0.5	-1.9	-2.3	-0.7	-2.4	-0.9	0.3	-1.9	-1.7	0.4	-0.0	-1.4	-2.0	-1.6	-0.9
Financial situation satisfaction	0.7	0.9	3.8	0.4	1.4	1.3	-0.3	0.4	0.4	0.2	1.1	1.4	-0.8	0.6	-0.3	1.1	-0.8	0.6	0.9	1.2	2.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.6	0.1	-0.9	-0.4	-1.3	0.6	-0.5	0.6	0.5	-0.4	-0.6	0.4	-0.2	-0.3	1.6	1.1	0.6	0.2	0.2
Commuting to job workplace: Public transport	1.7	2.0	5.5	-0.8	-1.9	-1.8	-0.2	-1.0	-0.7	-0.7	0.0	-2.2	-1.1	-1.6	-0.2	-1.6	1.7	-1.2	-2.0	-1.3	-2.3
Eye problems/disorders: Glaucoma	1.0	1.2	6.8	0.6	0.7	1.2	0.9	-0.1	0.3	-2.6	2.0	1.1	-0.6	-0.3	-0.4	1.1	-1.1	-0.9	-0.4	0.6	1.4
Medication: Blood pressure	1.0	1.8	6.5	-0.8	-2.4	-2.5	-0.7	-0.4	-0.7	0.4	-0.9	-1.9	-0.8	-0.7	0.1	-2.1	1.7	0.0	-0.6	-2.1	-0.9
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.5	-1.0	-0.8	0.6	0.6	-1.8	-1.9	-2.7	0.5	0.7	-0.1	-2.0	-2.3	1.1	-1.4	-1.6	-0.8	-0.5	0.9
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.2	-0.8	0.0	0.5	1.3	-1.9	-2.1	-1.4	0.3	0.9	0.7	-1.1	-1.8	1.1	-1.8	-0.8	-1.2	0.1	0.8
High cholesterol (Self-reported)	0.4	0.7	2.8	-1.2	-0.7	-0.5	-0.1	-1.0	-1.7	-1.1	-0.5	-0.1	-0.2	-0.5	-1.3	0.2	0.9	0.6	-0.8	-0.1	1.2
Medication: Bendroflumethiazide	0.5	0.8	2.9	0.0	-0.8	-1.5	-0.2	-0.1	-0.4	-0.6	-1.7	-0.7	-0.8	-0.8	0.8	-1.4	-0.1	-1.3	-0.4	-1.3	-0.8
Medication: Paracetamol	0.4	0.7	1.6	-1.1	-1.2	-0.9	-0.9	-0.9	-1.2	-0.7	-0.1	-1.0	-1.2	-0.1	-0.5	-0.3	0.7	0.2	-0.9	-0.9	-0.5
Medication: Lisinopril	0.4	0.5	1.7	-0.6	0.2	0.6	0.7	-0.8	-0.9	1.0	-1.3	0.2	1.1	-0.1	-0.3	1.0	-0.5	-0.4	-0.4	-0.0	0.4
Medication: Atorvastatin	0.6	0.8	2.5	0.6	0.8	0.5	-0.6	0.8	0.4	0.4	0.5	1.3	-0.4	1.0	0.0	0.5	-0.4	1.4	1.6	1.0	1.5
Illnesses of father: High blood pressure	0.9	1.1	3.8	1.7	0.5	-0.6	-0.0	1.5	1.0	0.1	-0.8	0.3	-1.3	-1.5	1.6	-1.1	-1.0	-1.9	0.0	0.3	-0.6
Alcohol drinker status: Never	0.5	0.6	1.8	0.7	0.4	-0.2	-0.3	0.9	1.3	1.3	-0.3	-0.3	-0.3	0.8	1.2	-0.6	0.7	0.4	0.8	0.8	-0.3
Ever smoked	0.8	1.4	4.8	0.9	0.1	-0.3	-1.4	1.5	1.4	-0.0	1.0	-0.9	-1.1	2.2	1.7	-0.7	1.2	1.8	1.3	-0.3	-0.6
Basal metabolic rate	1.6	8.6	21.5	-1.0	2.2	4.3	2.2	-1.7	-1.7	-1.6	0.6	4.4	3.6	-2.5	-3.2	4.6	-4.4	-2.6	-0.6	2.9	3.5
Leg fat percentage (left)	1.4	5.2	12.3	-2.2	0.1	2.4	2.2	-2.4	-2.7	-1.9	1.5	2.3	3.3	-0.4	-3.5	3.3	-2.7	0.5	0.2	0.2	3.5
Arm fat-free mass (left)	1.2	5.9	15.3	-0.4	1.9	3.6	2.0	-0.9	-0.9	-0.5	0.3	3.9	3.6	-1.5	-2.4	3.8	-3.6	-1.6	0.2	2.8	3.2
Number of operations (self-reported)	1.1	1.6	4.5	-1.0	-2.1	-1.9	-1.0	-0.5	-0.4	1.3	-1.5	-1.1	-1.0	1.0	-0.4	-1.3	1.6	2.0	0.7	-1.4	-0.8
Average weekly beer plus cider intake	0.5	0.8	3.5	-0.8	-0.2	-0.8	-0.0	-0.5	-0.6	-0.6	-1.9	-0.9	0.3	-0.9	0.1	-0.7	-0.3	-1.2	-1.3	-1.2	-1.3
Irritability	0.7	1.2	3.6	0.6	1.9	1.8	0.8	0.5	0.5	-1.2	-0.1	1.6	-0.4	-0.7	-0.1	1.5	-1.2	-0.9	-0.7	1.5	0.8
Risk taking	0.5	0.7	4.7	-0.4	-0.2	0.5	-2.2	0.4	-0.4	0.8	-1.1	0.0	-1.3	0.3	-0.6	0.6	1.0	0.9	0.1	0.4	0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.2	-0.8	-1.4	-1.2	-0.0	0.2	-0.7	0.2	-1.5	-1.2	-0.4	-0.2	-0.5	-0.7	2.1	0.4	-0.3	-0.4	0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.9	-0.5	-0.8	-0.5	-0.6	0.1	-0.6	0.4	1.4	-0.1	-0.4	-0.5	-1.3	-0.3	0.8	0.5	-0.4	-0.1	-0.2
Age started oral contraceptive pill	1.8	2.2	6.2	2.1	1.9	1.6	1.6	0.6	0.9	-0.7	1.5	2.5	0.8	0.6	0.4	1.1	-2.4	-0.0	1.4	1.4	2.1
Diastolic blood pressure, automated reading	0.8	2.5	9.7	0.9	2.0	1.7	2.6	0.4	0.2	-0.4	-0.3	1.9	1.8	-1.4	0.6	1.4	-3.1	-2.7	-0.3	0.3	1.1
Ever depressed for a whole week	1.5	1.8	5.0	-1.9	-2.2	-0.9	0.2	-1.7	-1.4	-0.5	1.3	-1.6	-0.6	1.1	-1.6	-0.1	1.5	2.1	-0.7	-1.6	-0.4
Unable to work because of sickness or disability	0.5	0.7	3.2	-1.1	-1.8	-1.1	-1.1	-1.0	-0.7	0.2	0.6	-0.5	-0.4	0.2	-0.9	-0.5	0.6	1.2	0.0	-0.2	0.1
Commuting to job workplace: Cycle	0.9	1.0	4.2	0.1	1.1	2.0	0.2	-0.6	-0.1	-0.3	0.7	0.9	0.9	1.0	-0.5	1.9	-0.7	0.7	0.5	1.3	1.6
Myopia	0.2	0.4	1.5	-0.1	-0.0	0.2	0.5	0.1	-0.3	-1.0	-0.1	-0.0	-0.2	-1.2	-0.2	0.0	-0.7	-1.1	-1.1	-0.7	-0.3
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.3	0.7	1.1	0.7	0.1	1.6	1.6	1.2	1.7	0.1	1.1	2.3	1.0	-0.0	1.1	2.2	1.6	0.7	-0.2
Cholesterol lowering medication	1.2	1.7	5.0	-1.0	0.3	1.1	1.5	-1.0	-1.9	-1.4	1.3	1.6	0.9	-1.3	-2.2	1.5	-0.5	-0.6	-0.8	0.6	2.0
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	10.4	-0.7	-1.9	-2.4	-2.0	1.1	-0.1	1.8	-3.2	-2.5	-1.2	-0.4	1.0	-2.5	2.8	-0.2	-1.2	-1.2	-2.2
Pain experienced in last month	1.3	2.2	6.4	1.8	1.1	0.4	-0.1	2.5	2.2	2.3	-0.5	-0.0	0.1	2.4	2.5	-0.3	0.8	0.9	2.0	0.4	-0.1
Supplements: Calcium	1.5	1.6	6.3	-2.0	-1.6	-0.3	-0.2	-2.5	-2.2	-0.6	-0.0	-0.2	-0.7	-0.5	-2.5	1.0	0.7	0.7	-1.1	0.3	0.9
Basal cell carcinoma (self-reported)	2.0	2.4	7.0	1.8	1.9	1.5	1.0	1.7	2.2	0.5	0.8	1.6	1.2	1.6	1.1	0.8	-1.2	0.7	2.6	1.2	2.1
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.3	-1.0	-1.0	-0.6	0.3	-1.3	-1.0	-2.0	-2.1	-0.7	0.0	-1.6	-1.1	-0.4	0.3	-1.1	-1.6	-0.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.7	0.3	0.3	-0.3	0.2	0.6	0.1	0.4	-0.8	0.0	0.5	0.6	0.4	-0.2	0.0	0.6	0.3	-0.5	0.3
Heart disease (siblings)	0.3	0.4	1.0	-0.7	0.8	0.9	0.3	-0.7	-0.9	-0.8	0.4	-0.0	0.6	-0.1	-0.8	1.0	-0.3	0.1	-1.0	-0.6	0.5
Alcohol drinker status: Previous	1.4	1.6	5.5	2.0	0.6	0.3	0.4	0.9	1.5	-0.2	1.4	1.6	0.7	1.4	0.7	0.2	-0.9	1.5	2.4	1.8	1.4
Pack years of smoking	0.6	0.9	3.0	1.7	0.6	0.2	-1.1	1.3	1.6	1.2	-0.9	0.0	-1.0	0.8	1.6	-0.5	-0.2	0.3	0.6	0.4	-0.4
Impedance of whole body	0.2	1.1	4.3	-0.2	1.1	1.4	1.6	-0.8	-0.5	-2.1	1.7	0.1	-0.3	-0.2	-0.4	1.2	-1.3	-1.2	-1.0	-0.6	-0.2
Leg fat mass (left)	2.1	8.2	21.3	-2.0	1.1	3.7	2.3	-2.4	-2.6	-2.1	1.7	3.8	3.6	-1.1	-4.0	4.6	-3.9	-0.4	0.1	1.6	4.3
Arm predicted mass (left)	1.0	5.3	13.6	-0.4	1.8	3.5	1.7	-0.7	-0.9	-0.3	0.1	3.7	3.4	-1.5	-2.2	3.6	-3.3	-1.7	0.1	2.7	3.0