Hub : Genes

SDHA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1170	0.0350	2.1e-11	0.062	0.107	0.106	0.114	0.107	4.8e-08	6.2e-13	7.4e-13	8.7e-14	5.4e-13
2	GTEx	Adipose Subcutaneous	0.1030	0.0400	4.1e-05	0.086	NA	0.055	NA	0.071	1.5e-07	NA	2.5e-05	NA	1.9e-06
3	GTEx	Adipose Visceral Omentum	0.0960	0.0470	6.2e-03	0.050	NA	0.042	NA	0.071	1.3e-03	NA	3.1e-03	NA	1.5e-04
4	GTEx	Artery Tibial	0.1275	0.0509	1.4e-03	0.002	NA	0.033	NA	0.009	2.0e-01	NA	1.2e-03	NA	6.2e-02
5	GTEx	Cells Transformed fibroblasts	0.2290	0.0610	9.6e-08	0.179	NA	0.128	NA	0.167	2.0e-13	NA	8.2e-10	NA	1.6e-12
6	GTEx	Heart Atrial Appendage	0.1470	0.0660	1.4e-03	0.037	NA	0.002	NA	0.020	8.6e-03	NA	2.7e-01	NA	4.3e-02
7	GTEx	Testis	0.3260	0.0920	6.4e-08	0.235	NA	0.181	NA	0.200	9.0e-11	NA	1.8e-08	NA	2.9e-09
8	GTEx	Whole Blood	0.0530	0.0250	2.3e-03	0.008	NA	0.004	NA	0.010	5.4e-02	NA	1.2e-01	NA	3.4e-02
9	METSIM	Adipose	0.0907	0.0356	4.4e-06	0.038	0.026	0.017	0.022	0.033	2.0e-06	7.6e-05	1.2e-03	2.2e-04	8.5e-06
10	ROSMAP	Brain Pre-frontal Cortex	0.0696	0.0297	1.2e-05	0.042	0.039	0.038	0.039	0.044	4.0e-06	8.2e-06	9.1e-06	7.1e-06	2.2e-06
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0430	0.0229	7.5e-06	0.033	0.049	0.042	NA	0.040	1.2e-04	3.3e-06	1.4e-05	NA	2.2e-05
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0550	0.0350	6.0e-03	0.016	0.003	0.002	NA	0.006	3.9e-02	2.1e-01	2.2e-01	NA	1.3e-01
13	TCGA	Thyroid Carcinoma	0.0590	0.0270	4.4e-07	0.091	0.078	0.080	NA	0.083	3.8e-09	4.9e-08	3.2e-08	NA	1.8e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.7	2.5	-1.0	0.9	0.7	-1.6	0.4	-1.2	0.5	-0.6	0.1	-0.5	0.6	0.8	0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	3.0	0.8	-0.5	-1.1	-0.7	-0.8	-0.2	-1.4	0.3	-1.0	1.7	-1.1	-0.9	-0.9
Depressed Affect (Nagel 2018)	0.3	0.5	4.3	-0.6	0.1	-0.5	-2.1	0.2	-0.5	0.5	-0.3	-0.1	0.6	0.5	-0.7	0.2
Depression (Nagel 2018)	0.1	0.2	1.7	0.0	-0.2	-0.1	-0.2	-0.1	1.3	0.4	0.4	-0.1	-0.2	0.1	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.7	-0.3	0.6	0.6	0.0	0.4	-0.4	1.3	0.2	-0.2	-1.1	0.4	0.5	0.2
Neuroticism (Nagel 2018)	0.4	1.0	4.9	-1.0	0.7	-0.3	-2.2	0.9	-0.7	1.2	-0.8	0.4	0.6	1.4	-0.6	0.8
Schizophrenia (2018)	1.3	2.7	7.0	1.8	-1.4	-1.9	0.4	-1.4	0.7	-2.3	0.9	-1.3	2.6	-1.8	-1.9	-1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	0.0	-0.6	0.2	0.4	-0.2	-0.6	-1.3	-0.4	0.1	0.8	-1.0	0.3	-0.5
Worry (Nagel 2018)	0.5	1.0	6.9	-0.9	0.6	-0.1	-2.6	0.8	-0.6	0.5	-0.9	0.4	0.8	1.0	-0.4	0.7
Alzheimer’s Disease (in mother)	0.3	0.4	1.8	-0.2	-0.1	-0.1	-1.3	0.6	-0.5	-0.0	-0.5	0.5	0.9	0.6	-0.3	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.0	-0.4	0.0	-0.6	-0.2	-0.5	-0.5	-0.2	0.3	0.8	-0.6	0.1	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	3.9	-0.2	-0.4	0.0	-2.0	0.6	-0.8	-0.1	-0.7	0.9	1.3	0.5	-0.4	0.5
Crohns Disease (2017)	0.3	0.8	3.6	-0.9	0.6	1.0	-0.1	0.6	-1.9	-0.3	-1.1	0.6	0.4	0.2	1.3	0.1
Irritable Bowel Disease (IBD)	1.0	2.4	5.6	-1.6	1.5	2.0	0.7	1.2	-2.4	1.2	-1.4	1.2	-1.8	1.4	2.1	0.7
Ulcerative Colitis (UC)	1.5	2.8	8.6	-1.5	1.6	2.0	1.2	1.1	-1.5	2.1	-0.8	1.0	-2.9	1.9	1.8	0.8
Major Depression (MDD)	0.2	0.2	0.6	0.6	-0.5	-0.7	0.3	-0.5	0.5	0.1	0.3	-0.3	0.1	-0.5	-0.8	-0.6
Reaction Time	0.2	0.4	2.2	-1.0	0.4	0.7	1.5	-0.2	0.3	-0.7	-0.2	-0.2	-0.5	-0.4	1.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.2	0.2	-0.5	-0.3	0.5	-0.8	-0.4	-0.1	0.5	-1.1	0.2	-0.8	-0.4	-0.9
Breast Cancer	4.1	9.8	25.7	3.3	-3.4	-2.4	1.9	-3.1	5.1	-2.4	4.0	-3.0	1.3	-3.5	-2.4	-3.2
Ovarian Cancer	4.0	5.3	8.8	2.8	-2.2	-2.7	0.5	-2.3	3.0	-1.6	2.6	-2.5	1.7	-2.0	-2.7	-2.3
Prostate Cancer	0.3	0.4	1.1	-0.6	1.1	0.8	0.1	0.6	-0.2	1.1	-0.3	-0.1	-0.3	0.9	0.6	0.6
Age at First Birth	1.0	1.5	5.7	-0.6	1.0	0.2	-2.4	1.2	-1.6	0.4	-1.6	0.9	1.2	1.3	-0.1	1.2
Bipolar Disorder (2011)	0.5	0.5	0.9	0.8	-0.5	-0.8	0.3	-0.6	1.0	-0.7	0.9	-0.7	0.7	-0.7	-0.5	-0.7
Body Mass Index (BMI) (2010)	0.4	0.5	1.7	0.6	-0.7	-0.6	1.3	-0.6	0.1	-1.2	0.6	-0.6	0.5	-0.7	-0.3	-0.7
Coronary Artery Disease (CAD)	0.0	0.1	0.2	-0.1	-0.4	-0.0	-0.2	-0.1	-0.3	0.0	0.2	0.4	-0.3	-0.1	-0.1	-0.2
Crohns Disease (2012)	1.5	2.4	7.1	-1.6	1.5	1.8	-1.0	1.5	-2.7	1.0	-1.6	1.4	-0.6	1.2	1.9	1.3
Mean Putamen Volume	0.4	0.4	1.0	0.9	-1.0	-0.8	0.3	-0.6	0.8	-0.3	0.4	-0.4	0.7	-0.5	-0.9	-0.3
Fasting Glucose	0.4	0.5	2.2	-0.1	0.6	0.9	1.2	-0.1	1.0	-1.5	-0.0	-0.1	0.4	-0.8	0.7	-0.1
HbA1C	2.8	3.1	7.6	-2.1	1.7	1.9	-1.0	1.6	-2.8	0.3	-2.3	1.4	-0.2	1.3	2.3	1.8
HDL Cholesterol	0.9	1.5	2.4	1.5	-1.6	-1.5	0.7	-1.4	1.2	-0.4	1.4	-1.2	0.5	-1.1	-1.4	-1.5
LDL Cholesterol	0.1	0.2	1.1	-0.1	0.2	-0.1	-0.3	0.2	1.1	-0.2	0.2	0.3	0.5	0.5	-0.3	0.2
Lupus	0.4	0.6	2.2	-0.9	0.8	-0.1	-1.5	0.5	-1.0	0.7	-1.0	0.3	-0.2	0.9	0.2	0.2
Neuroticism (2016)	0.6	0.8	1.6	-0.9	1.2	0.4	-1.1	1.3	-1.0	0.9	-0.9	0.6	0.7	0.9	0.5	1.1
Primary Biliary Cirrhosis	1.4	2.0	3.7	-1.1	1.7	1.4	-1.9	1.6	-1.3	0.8	-1.1	1.8	-0.8	1.5	1.2	1.6
Rheumatoid Arthritis	0.2	0.2	1.3	-0.4	-0.2	0.5	0.2	-0.1	-0.6	-1.1	-0.1	-0.2	0.1	-0.8	0.7	-0.1
Schizophrenia (2014)	0.2	0.5	1.8	0.4	-0.2	-0.2	-0.3	-0.4	-1.0	-1.2	-0.2	-0.5	1.4	-0.8	-0.3	-0.4
Triglycerides	0.2	0.4	1.5	0.5	-0.3	-0.4	0.0	-0.4	1.2	0.4	0.8	-0.4	-1.2	0.3	-0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	-1.4	1.1	0.8	-1.0	0.8	-1.4	-0.3	-1.2	0.6	0.2	0.5	0.5	0.8
Ulcerative Colitis	0.4	0.5	2.0	-0.5	0.6	0.7	-1.0	0.4	-1.0	0.8	-0.4	-0.0	-1.4	0.7	0.4	0.4
Blood Eosinophil Count	0.1	1.0	3.2	1.1	-1.0	-1.4	0.5	-0.6	0.3	-1.0	0.1	-1.1	1.8	-0.5	-1.6	-0.6
Blood Platelet Count	1.1	12.3	19.0	-3.8	4.0	3.3	-0.8	3.5	-3.9	4.3	-3.2	2.7	-3.8	4.4	3.1	3.5
Blood Red Count	0.1	0.9	2.5	-1.6	0.3	1.2	-0.7	0.8	-0.1	0.9	-0.6	1.4	0.1	0.7	1.3	0.8
Blood White Count	0.4	3.0	6.3	-2.1	1.6	1.3	-0.7	1.8	-1.4	2.4	-1.8	1.2	-1.6	2.5	1.3	1.8
Heel T-Score	0.5	4.3	7.9	2.1	-2.3	-2.2	1.1	-2.4	2.4	-1.6	2.8	-2.2	0.6	-1.9	-2.0	-2.4
BMI	1.8	10.5	15.2	-3.6	3.5	2.8	-2.9	3.9	-3.2	3.2	-3.9	3.2	-0.5	3.8	2.4	3.7
Height	3.9	75.8	106.3	-9.5	9.5	9.1	-1.7	9.1	-10.3	8.6	-8.5	8.6	-7.8	9.6	8.8	9.0
Waist Hip Ratio (WHR)	0.7	3.1	5.4	-2.3	2.2	1.7	-0.6	1.9	-1.7	1.9	-1.6	1.1	-1.5	2.2	1.6	1.7
Systolic Blood Pressure	1.6	7.9	24.6	-2.4	2.7	2.4	1.5	2.3	-1.5	5.0	-1.1	1.8	-4.7	3.6	2.2	2.1
Smoking Status	0.2	0.4	1.9	-0.1	-0.4	-0.3	0.6	-0.4	-0.6	-1.4	-0.2	-0.7	1.1	-0.9	-0.2	-0.3
Allergy or Eczema	0.1	0.4	1.0	1.0	-0.5	-0.7	-0.6	-0.4	0.3	0.6	0.7	-0.5	-0.3	0.1	-0.9	-0.6
Cardiovascular Disease	2.0	6.7	13.7	-2.2	2.9	2.5	-0.1	2.8	-0.7	3.7	-1.9	3.1	-2.8	3.5	2.2	2.8
Hypothyroidism (self reported)	0.1	0.3	1.3	0.4	0.4	0.4	0.5	0.4	1.1	0.0	0.1	0.4	0.9	-0.2	0.4	0.3
Respiratory disease	0.5	1.0	4.1	0.4	0.8	0.4	-1.2	1.3	0.5	0.3	-1.0	1.0	2.0	1.0	0.1	1.4
Type 2 Diabetes (T2D) (2018)	1.5	2.9	4.4	-2.1	1.6	1.3	-1.9	1.9	-2.1	1.5	-2.1	1.6	-0.1	1.9	0.9	1.7
Lung FEV1/FVC ratio	0.5	2.5	7.1	-1.8	1.4	2.4	0.7	1.2	-1.9	-0.3	-1.7	1.7	-1.2	-0.0	2.7	1.2
Lung FVC	0.2	0.9	4.0	-0.2	-1.1	-0.5	0.2	-1.1	0.6	0.5	1.7	-0.9	-2.0	0.1	-0.2	-1.0
Neuroticism	0.4	1.1	5.4	-0.7	0.6	-0.3	-2.3	0.8	-0.4	1.2	-0.8	0.5	1.1	1.4	-0.8	0.8
Chronotype (morning person)	1.6	3.6	6.9	1.9	-2.3	-2.3	1.6	-2.2	2.2	-0.0	2.6	-1.9	-0.6	-1.1	-2.1	-2.2
Hair Pigment	0.1	1.6	3.7	1.9	-1.3	-1.4	0.8	-1.3	1.5	-0.9	1.8	-0.7	-0.2	-0.7	-1.5	-1.3
Tanning	0.3	3.8	16.6	-2.0	1.5	2.0	1.0	1.2	-1.6	2.7	-0.5	0.9	-4.1	1.8	2.1	1.1
Hand grip strength (left)	1.8	4.6	8.5	-2.0	2.1	2.6	0.2	2.0	-2.9	1.3	-2.2	2.3	-2.6	1.7	2.6	2.0
Number of treatments/medications taken	0.3	0.5	1.1	-0.4	0.6	0.0	-0.8	0.9	-0.0	1.0	-0.8	1.0	0.4	1.0	-0.3	1.0
Average weekly spirits intake	0.6	0.7	2.6	0.8	-0.3	-0.9	-0.1	-0.5	0.8	-1.6	0.4	-0.6	1.3	-0.8	-1.0	-0.5
Sensitivity / hurt feelings	2.3	3.9	6.7	-1.8	2.1	1.4	-2.4	2.3	-1.9	2.1	-2.1	2.1	0.6	2.6	0.9	2.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.4	0.6	0.7	-0.7	0.6	1.0	0.3	-0.3	0.6	0.7	0.3	0.6	0.7
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.4	-0.1	0.1	0.7	-0.1	0.6	0.1	0.3	-0.2	0.5	-0.0	0.2	-0.1
Relative age of first facial hair	2.4	4.9	8.9	-2.1	2.6	2.3	0.5	2.4	-1.1	3.0	-1.6	2.3	-2.4	2.8	2.2	2.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.7	-0.8	0.8	0.8	-1.6	1.2	-0.6	0.7	-0.8	0.9	1.0	0.9	0.4	1.2
Ever used hormone-replacement therapy (HRT)	2.4	3.1	6.1	1.6	-1.7	-1.5	1.0	-1.9	1.9	-2.5	1.3	-1.5	2.0	-2.3	-1.3	-1.7
Ever had hysterectomy (womb removed)	0.2	0.2	2.3	0.2	-0.4	0.1	1.5	-0.4	0.2	-0.1	0.3	-0.0	-0.3	-0.2	0.1	-0.3
Systolic blood pressure, automated reading	2.0	5.8	14.3	-2.5	2.6	2.3	0.6	2.3	-1.5	3.8	-1.6	2.0	-3.0	3.1	2.2	2.2
Eye problems/disorders: Diabetes related eye disease	2.7	2.9	5.5	-1.1	1.6	1.0	0.9	1.8	-2.1	2.3	-1.6	1.8	-2.1	2.4	0.8	1.8
Angina	0.2	0.3	2.0	-0.1	-0.0	-0.3	-0.3	0.1	0.7	1.4	0.4	0.2	-0.6	0.8	-0.3	0.1
Medication for hormone replacement therapy	0.5	0.6	1.7	0.5	-0.4	-0.4	0.2	-0.6	1.3	-1.0	0.5	-0.7	1.2	-1.0	-0.4	-0.6
Vitamin and mineral supplements	1.3	1.8	4.6	1.2	-1.4	-0.9	2.1	-1.4	1.9	-1.0	1.6	-1.1	-0.9	-0.9	-0.8	-1.3
Supplements: Zinc	0.7	0.7	1.1	-0.9	0.9	0.6	-0.9	1.0	-1.0	0.8	-1.1	0.9	0.2	0.7	0.6	0.9
Medication: Co-codamol	1.2	1.4	5.3	0.5	-0.8	-0.8	-0.8	-1.1	0.5	-2.3	0.4	-1.1	2.1	-1.5	-0.7	-1.0
Medication: Metformin	3.1	4.4	6.7	-2.6	2.0	2.1	-0.1	2.2	-2.4	2.6	-1.9	1.9	-2.2	2.3	1.8	2.0
Diabetes (father)	0.2	0.2	1.6	-0.6	0.1	-0.2	0.2	0.2	-1.3	-0.6	-0.5	-0.3	0.3	0.0	-0.2	0.0
Diabetes (mother)	0.6	0.8	4.3	-0.8	-0.3	-0.3	-0.5	0.0	-1.2	1.5	-0.1	0.4	-2.1	1.1	-0.2	-0.1
Severe depression (siblings)	0.8	0.9	2.4	1.2	-0.8	-1.0	0.0	-0.9	0.6	-0.9	0.6	-1.6	0.6	-1.2	-1.0	-0.8
Pack years adult smoking proportion	0.2	0.2	0.6	0.7	-0.7	0.1	-0.1	-0.5	0.5	-0.8	0.7	-0.2	0.1	-0.5	0.2	-0.5
Impedance of leg (right)	0.1	0.2	1.8	-0.2	0.1	-0.2	-1.0	-0.0	-1.3	-0.2	-0.3	0.1	0.2	-0.1	-0.4	0.1
Leg fat-free mass (left)	3.5	18.6	25.4	-4.2	4.8	4.7	-1.0	5.0	-4.0	4.7	-4.2	4.3	-3.1	5.0	4.4	4.8
Trunk fat percentage	4.6	18.4	25.4	-4.6	4.7	4.0	-3.9	5.0	-4.5	4.1	-4.8	4.2	-1.3	4.9	3.5	5.0
Hand grip strength (right)	0.9	2.4	9.1	-1.2	1.2	1.8	0.3	1.0	-2.1	1.0	-1.1	1.2	-3.0	1.1	1.9	0.9
Townsend deprivation index at recruitment	0.6	0.9	4.2	0.7	-0.6	-0.2	0.1	-0.6	0.0	-2.1	0.2	-0.6	1.6	-1.5	-0.0	-0.7
Current tobacco smoking	0.9	1.4	4.0	0.9	-1.1	-1.1	0.7	-1.2	0.1	-2.0	0.5	-1.4	1.4	-1.7	-1.1	-1.1
Average weekly fortified wine intake	2.6	3.0	4.9	-1.7	2.0	1.2	-0.9	1.9	-2.2	2.1	-2.1	1.6	-1.1	2.2	0.9	1.9
Maternal smoking around birth	0.5	0.7	1.6	1.1	-0.9	-1.0	-1.0	-0.6	0.8	0.7	1.3	-0.2	-0.2	0.2	-1.0	-0.7
Fed-up feelings	0.1	0.2	0.9	-0.2	0.3	-0.3	-1.0	0.5	0.1	0.8	-0.1	0.3	-0.1	0.8	-0.4	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.2	0.6	0.3	-0.4	0.6	0.8	0.8	-0.3	0.5	-0.3	0.6	0.3	0.7
Relative age voice broke	0.2	0.3	0.7	-0.3	0.7	0.5	0.0	0.5	-0.3	0.9	-0.2	0.1	-0.8	0.7	0.4	0.4
Taking other prescription medications	1.0	1.5	4.0	-0.9	1.4	0.6	-2.0	1.4	-0.6	0.5	-1.3	1.6	1.1	1.4	0.5	1.5
Age when periods started (menarche)	0.1	0.3	0.7	0.4	-0.6	-0.4	0.6	-0.4	0.8	-0.7	0.4	-0.1	0.8	-0.4	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	3.1	0.0	-0.3	0.1	1.8	-0.1	-0.1	0.1	0.0	0.0	-0.9	0.1	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	-0.6	-0.0	-0.6	-1.1	-0.1	-0.8	0.4	-0.1	-0.1	-1.0	0.8	-0.5	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	1.0	0.5	0.1	-0.0	-0.1	0.1	0.2	1.0	0.1	0.1	-0.0	0.3	-0.0	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.2	-0.7	0.1	0.9	0.9	0.3	-1.1	-0.4	-0.7	0.2	-0.2	-0.2	1.0	0.3
Serious illness, injury or assault to yourself	4.6	5.6	7.8	-2.4	2.7	2.3	-2.2	2.7	-1.4	2.4	-2.5	2.7	-0.9	2.6	2.2	2.8
High blood pressure	0.5	1.5	3.5	-0.8	1.3	1.1	0.9	1.4	0.1	1.6	-0.8	1.9	-0.7	1.8	0.8	1.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.7	1.3	-1.0	-1.1	-0.9	-0.8	0.1	-0.5	0.9	-1.0	0.7	-0.8	-1.3	-1.0
Multivitamins +/- minerals	0.8	1.0	2.5	-0.9	0.8	1.0	-1.2	1.0	-1.6	0.2	-1.4	0.8	1.0	0.4	1.0	0.9
Stomach or abdominal pain in last month	2.3	2.9	3.8	1.3	-1.9	-1.9	-0.5	-1.8	1.7	-1.8	1.5	-1.8	1.9	-1.5	-1.9	-1.8
Supplements: Glucosamine	0.3	0.4	3.1	0.0	0.3	-0.1	-1.8	0.5	-0.4	0.5	-0.6	0.3	0.7	0.4	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	5.6	0.1	-1.2	-0.7	-1.4	-1.1	-0.9	-2.1	-0.1	-0.4	2.4	-1.8	-0.6	-1.0
Medication: Atenolol	1.1	1.3	4.3	0.7	-1.0	-0.6	2.1	-1.1	2.0	0.3	1.4	-1.1	-0.8	-0.6	-0.4	-1.2
Medication: Levothyroxine sodium	0.6	1.0	2.7	0.2	0.9	1.0	-1.1	1.2	1.0	-0.0	-0.8	1.6	1.4	0.4	0.9	1.2
Sitting height	5.7	40.3	58.7	-6.2	7.1	6.4	-2.7	7.1	-6.1	6.7	-6.2	6.6	-5.1	7.7	6.0	7.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	0.8	-0.7	-0.7	-1.1	-0.6	0.9	0.4	1.3	-0.2	-0.6	0.1	-0.7	-0.7
High blood pressure (mother)	3.1	4.3	7.2	2.7	-2.3	-2.5	0.6	-2.2	1.9	-1.5	1.9	-2.2	1.1	-2.1	-2.5	-2.1
Body mass index (BMI)	1.5	6.2	10.2	-2.8	2.5	2.2	-2.7	3.1	-2.4	1.8	-3.2	2.6	0.7	2.6	1.9	3.0
Impedance of leg (left)	0.1	0.4	1.6	0.0	-0.3	-0.5	-1.3	-0.4	-1.3	-0.6	-0.0	-0.2	0.2	-0.4	-0.5	-0.3
Leg predicted mass (left)	3.4	17.9	24.7	-4.1	4.7	4.6	-1.0	4.9	-3.9	4.7	-4.1	4.3	-3.1	5.0	4.3	4.8
Trunk fat mass	5.6	24.2	33.5	-5.2	5.5	4.8	-3.6	5.8	-5.0	4.7	-5.5	5.0	-1.8	5.6	4.3	5.7
Waist circumference	5.9	21.7	29.8	-5.3	5.2	4.5	-3.4	5.5	-4.9	4.1	-5.4	4.6	-1.1	5.1	4.1	5.3
Number of incorrect matches in round	0.1	0.2	0.7	0.4	0.5	0.0	-0.2	0.6	0.1	0.0	-0.8	0.5	0.6	0.3	0.1	0.6
Past tobacco smoking	0.3	0.6	1.7	-0.7	0.8	0.5	-0.2	0.7	-0.7	0.7	-0.7	0.9	-1.3	1.0	0.6	0.6
Alcohol usually taken with meals	0.3	0.5	2.8	0.4	-0.5	-0.3	-0.4	-0.2	1.0	1.7	0.6	-0.3	-0.3	0.5	-0.6	-0.3
Nervous feelings	1.5	2.9	6.3	-1.7	1.8	1.1	-2.5	2.0	-1.7	0.9	-2.3	1.6	1.3	1.6	0.7	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.3	0.2	0.1	-0.0	-1.2	0.2	0.6	0.6	0.1	-0.3	-0.4	0.5	0.0	0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.9	-0.1	-0.2	-0.3	-0.2	0.1	0.5	-0.1	0.0	-0.1	1.0	0.2	-0.3	0.1
Hair/balding pattern: Pattern 2	3.2	4.0	11.1	2.7	-1.9	-1.6	1.6	-1.6	3.3	-1.8	2.1	-1.4	1.9	-2.2	-1.7	-1.5
Had menopause	0.1	0.1	0.5	-0.7	-0.3	-0.1	0.3	-0.2	-0.1	0.5	-0.1	0.0	-0.5	-0.1	-0.1	-0.2
Had other major operations	0.3	0.4	2.5	-0.1	-0.2	-0.1	-1.2	0.0	-0.3	-0.8	-0.1	-0.2	1.6	-0.1	-0.1	0.0
Forced vital capacity (FVC)	2.0	7.8	20.3	-2.6	2.7	2.9	0.5	2.4	-3.0	3.4	-1.6	2.2	-4.5	3.2	2.9	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.8	-0.4	-0.2	-0.8	-1.4	-0.0	-0.8	-0.2	-0.3	-0.2	-0.0	0.2	-0.7	-0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.1	-0.3	-0.5	-0.6	-0.3	0.4	-0.5	0.3	-0.7	0.4	-0.4	-0.5	-0.2
Qualifications: None of the above	0.3	0.7	3.1	0.9	-0.8	-1.6	-0.6	-0.8	0.1	-0.5	0.3	-0.5	0.3	-0.2	-1.8	-0.7
Financial difficulties in last 2 years	0.3	0.4	1.7	-0.3	0.2	1.1	0.4	0.7	0.5	-0.4	-0.1	0.7	0.3	0.3	1.3	0.7
Mouth/teeth dental problems	0.2	0.3	1.1	-0.0	0.7	0.3	-0.4	0.4	-0.0	1.0	-0.2	0.4	-1.0	0.5	0.4	0.4
Heart attack	0.2	0.2	1.6	0.2	-0.2	-0.3	0.2	-0.0	0.3	1.3	0.2	-0.1	-0.6	0.7	-0.4	-0.1
Allergy	0.6	1.5	2.6	-1.5	1.4	1.5	1.4	0.9	-0.6	0.6	-1.0	1.3	-1.6	0.6	1.6	1.0
Pain all over the body in last month	0.7	0.8	1.9	-0.8	1.1	1.4	-0.6	1.0	-0.0	0.4	-0.6	0.8	-0.5	0.8	1.3	1.1
Diabetes (self-reported)	0.8	1.2	2.2	-1.3	1.1	0.5	-0.4	1.3	-1.4	1.3	-1.3	1.1	-0.4	1.5	0.2	1.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.7	1.3	-1.0	-1.9	-1.1	-1.1	0.7	-0.8	1.1	-1.3	1.2	-0.7	-1.8	-1.2
Medication: Ramipril	0.3	0.4	1.0	-1.0	0.1	0.7	-0.0	0.6	-0.3	0.3	-0.7	0.8	-0.6	0.7	0.7	0.7
Medication: Simvastatin	2.7	3.9	7.7	-2.1	2.0	1.6	-0.9	2.3	-1.3	2.8	-2.0	2.1	-1.4	2.6	1.2	2.3
Fluid intelligence score	0.2	0.5	1.4	-0.8	0.7	0.8	0.6	0.5	-1.2	1.1	-0.6	0.2	-0.5	0.3	0.7	0.4
Illnesses of siblings	0.3	0.5	1.0	0.7	-0.7	-0.4	0.9	-0.7	1.0	-0.1	0.9	-1.0	0.3	-0.6	-0.2	-0.7
Neuroticism score	0.9	1.9	5.3	-1.4	1.5	0.6	-2.3	1.6	-0.8	1.7	-1.3	1.2	0.6	1.9	0.2	1.5
Weight	4.5	22.3	30.2	-5.1	5.1	4.7	-2.9	5.5	-5.0	4.5	-5.2	4.9	-2.1	5.3	4.3	5.4
Impedance of arm (right)	0.2	0.9	2.7	-0.4	1.2	0.1	-0.6	0.7	-1.0	1.6	-0.5	0.2	-1.6	1.5	0.1	0.8
Arm fat percentage (right)	2.5	10.0	15.0	-3.5	3.5	2.5	-3.3	3.8	-3.5	2.8	-3.9	2.9	-0.1	3.7	2.0	3.7
Trunk fat-free mass	2.2	12.5	16.6	-3.5	3.8	3.8	-0.9	4.1	-3.8	3.5	-3.8	3.9	-2.0	4.0	3.5	3.9
Hip circumference	6.3	27.1	35.9	-5.8	5.7	5.2	-3.4	6.0	-5.9	4.7	-5.9	5.3	-1.9	5.6	4.8	5.9
Time employed in main current job	1.6	1.9	3.4	1.4	-1.8	-1.1	0.7	-1.7	0.9	-1.3	1.9	-1.4	0.1	-1.6	-1.0	-1.8
Alcohol intake versus 10 years previously	1.0	1.6	4.2	-1.4	1.6	1.3	0.5	1.0	-1.3	1.3	-0.8	0.8	-2.0	1.2	1.2	1.1
Father’s age at death	0.9	1.3	5.3	1.8	-0.7	-1.5	0.2	-0.6	2.3	-0.0	0.8	-0.7	0.6	-0.6	-1.6	-0.6
Worrier / anxious feelings	0.7	1.3	5.3	1.0	-0.4	-1.5	-2.3	-0.4	0.6	0.3	0.5	-0.9	1.6	0.3	-1.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.3	-1.5	1.1	1.1	-2.1	1.5	-1.4	0.8	-1.7	1.5	0.8	1.3	1.1	1.5
Falls in the last year	0.8	1.0	3.6	-0.7	1.0	0.4	-0.5	1.1	-0.2	1.9	-0.3	0.7	-1.2	1.9	0.2	1.0
Hair/balding pattern: Pattern 3	0.3	0.4	2.3	-0.4	0.5	-0.2	-1.5	0.3	-0.3	0.0	-0.9	0.4	0.7	0.8	-0.1	0.4
Number of live births	0.4	0.5	1.1	-1.0	0.8	0.7	-0.4	0.9	0.2	0.4	-0.8	1.1	0.4	0.6	0.7	0.9
Forced expiratory volume in 1-second (FEV1)	2.9	9.9	20.8	-3.1	3.0	3.7	-0.1	2.8	-3.7	3.3	-2.1	2.8	-4.6	3.2	3.7	2.7
Pulse rate	1.0	1.6	6.6	0.4	-0.8	-0.8	0.9	-0.8	-0.4	-2.6	-0.3	-1.0	2.4	-1.8	-0.8	-0.6
Happiness	0.1	0.1	0.6	0.1	-0.1	0.3	0.8	-0.3	-0.3	-0.5	0.2	-0.5	0.1	-0.5	0.5	-0.2
Noisy workplace	0.1	0.2	0.5	0.3	-0.3	-0.5	-0.7	-0.2	0.6	-0.4	-0.0	0.2	0.7	-0.1	-0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.0	-0.2	0.5	0.4	-1.7	0.6	-1.2	-0.3	-0.9	0.2	0.9	0.3	0.3	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.7	-0.0	-0.2	0.1	0.0	-0.4	0.1	-0.1	0.3	-0.2	0.0	-0.3	0.2
Mouth/teeth dental problems: Dentures	0.3	0.6	1.4	-1.0	0.4	1.0	-0.9	0.3	-1.2	-0.9	-0.8	0.2	0.6	0.0	1.0	0.4
Asthma	0.2	0.4	2.4	0.6	-0.2	-0.3	-1.6	0.3	0.5	0.1	-0.3	0.1	1.3	0.6	-0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	3.1	-1.6	1.6	1.7	-0.3	1.8	-1.2	0.2	-1.7	1.8	0.5	1.0	1.7	1.8
Medication: Cholesterol lowering	0.4	0.6	1.2	-0.7	0.6	0.7	-0.4	1.0	-0.3	1.1	-0.7	1.1	0.1	0.9	0.4	1.0
Depression (self-reported)	0.9	1.1	2.0	-1.4	1.4	1.3	-0.1	1.3	-1.2	0.5	-1.2	0.5	-0.4	0.5	1.1	1.2
Medication: Lansoprazole	1.2	1.4	2.6	0.7	-1.6	-1.4	-0.8	-1.3	-0.4	-1.1	0.8	-1.0	1.6	-1.1	-1.3	-1.3
Prospective memory result	1.7	2.1	5.2	1.4	-1.4	-1.2	1.0	-1.2	2.3	-1.9	1.2	-1.1	1.5	-1.7	-1.1	-1.2
Lung cancer (father)	0.2	0.2	1.1	-0.3	-0.3	-0.1	-0.2	-0.3	-0.5	0.5	0.3	-0.6	-1.0	0.1	-0.2	-0.3
Illnesses of mother	1.8	2.2	4.6	-2.1	1.9	1.9	0.0	1.4	-0.5	1.1	-1.3	1.3	-1.2	1.4	2.1	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	15.8	-2.8	3.1	3.6	-0.4	2.7	-3.5	2.8	-2.3	3.0	-4.0	2.8	3.7	2.7
Pulse wave Arterial Stiffness index	0.7	0.9	2.1	-1.4	1.3	1.1	-0.0	0.8	-1.3	-0.1	-0.9	0.5	-0.9	0.5	1.1	0.8
Impedance of arm (left)	0.3	1.3	5.7	-0.6	1.4	0.4	-0.2	0.7	-0.9	1.8	-0.2	0.2	-2.4	1.7	0.4	0.8
Arm fat mass (right)	3.7	15.3	22.2	-4.2	4.3	3.6	-3.4	4.7	-4.1	3.5	-4.6	4.0	-0.6	4.5	3.1	4.6
Trunk predicted mass	2.1	12.1	16.1	-3.5	3.7	3.8	-0.9	4.0	-3.8	3.5	-3.7	3.8	-1.9	3.9	3.5	3.9
Standing height	3.3	32.4	43.1	-5.3	6.3	5.9	-1.4	6.1	-6.2	6.3	-5.2	5.6	-5.6	6.6	5.7	6.0
Length of working week for main job	1.7	1.9	5.6	1.1	-1.4	-0.8	0.2	-1.4	0.2	-2.4	1.2	-1.4	1.7	-2.2	-0.7	-1.4
Exposure to tobacco smoke at home	0.5	0.5	1.2	-0.0	-0.7	-0.5	1.0	-0.8	-0.1	-1.0	0.6	-1.1	-0.6	-0.5	-0.4	-0.9
Breastfed as a baby	0.8	0.9	2.1	0.5	-1.4	-0.6	0.8	-1.4	0.0	-0.3	1.3	-1.0	-0.6	-1.2	-0.4	-1.4
Tense / ‘highly strung’	0.2	0.4	1.9	-0.6	0.3	-0.1	-1.4	0.2	0.5	1.0	0.1	-0.0	-0.1	1.1	-0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	7.8	0.9	-0.2	-0.4	-2.3	0.2	0.8	-1.0	-0.1	0.0	2.8	-0.7	-0.8	0.1
Hair/balding pattern: Pattern 4	0.7	1.8	5.0	0.9	-1.1	-1.4	0.2	-1.4	0.6	-2.2	0.6	-1.5	1.8	-1.7	-1.3	-1.3
Birth weight of first child	0.3	0.6	2.7	0.2	-0.1	-0.0	0.1	0.3	0.7	1.6	0.3	0.2	-1.6	1.2	-0.1	0.3
Peak expiratory flow (PEF)	1.5	3.4	11.3	-1.5	1.2	2.0	-0.7	1.4	-2.4	1.7	-1.0	1.8	-3.4	1.8	2.2	1.4
Pulse wave reflection index	0.9	1.1	5.4	-0.9	1.3	1.1	-0.0	0.6	-0.7	1.4	-0.4	0.1	-2.3	0.8	1.0	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	2.1	0.1	-0.0	-0.6	-1.5	0.2	-0.2	-0.4	-0.2	-0.3	0.9	0.5	-0.6	0.3
Loud music exposure frequency	0.4	0.4	2.1	0.5	-0.4	-0.7	-0.6	-0.3	0.7	-0.4	0.3	-0.1	1.5	-0.6	-0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.2	-0.7	0.0	0.8	-0.6	0.7	-0.1	0.9	-0.6	-0.4	-0.4	0.3	-0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	0.6	-1.1	-1.0	0.9	-0.8	0.5	-0.1	1.0	-0.8	0.4	-0.5	-1.0	-0.8
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.5	-0.2	-0.2	-0.4	-0.0	-0.3	-0.1	-0.4	0.1	0.2	0.1	-0.1	-0.0
Medication: Paracetamol	0.3	0.5	1.8	0.8	-0.6	-0.5	0.6	-0.3	1.3	-0.6	0.8	-0.1	0.9	-0.3	-0.7	-0.3
Headache pain in last month	0.4	0.6	1.6	0.4	-1.1	-0.6	0.7	-1.0	1.1	-0.4	1.2	-0.6	-0.5	-0.4	-0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.7	0.7	-0.7	-0.5	0.3	-1.0	0.1	-1.9	0.6	-1.1	0.6	-1.3	-0.3	-1.0
Glaucoma (self-reported)	1.7	2.1	3.6	-1.4	1.9	1.4	0.2	1.6	-1.0	1.9	-0.9	1.2	-1.3	1.8	1.4	1.6
Gout (self-reported)	0.2	0.3	1.6	-0.2	0.2	0.1	1.3	0.1	0.5	1.1	0.6	0.0	-0.5	0.5	0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.9	0.5	0.3	0.2	-1.0	0.6	0.9	-0.0	-0.4	0.9	1.7	0.2	-0.0	0.5
Medication: Amlodipine	1.3	1.8	4.8	1.9	-0.8	-1.9	1.3	-0.9	2.2	0.6	1.2	-0.7	1.0	-0.2	-2.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.0	0.4	0.0	0.2	-1.0	0.3	-0.7	-0.3	-0.8	0.7	0.9	0.1	0.3	0.4
Birth weight	1.3	2.8	5.2	-1.8	0.9	1.0	-1.6	1.6	-2.3	1.8	-1.7	1.9	-1.4	2.3	1.2	1.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.2	-0.1	0.1	0.2	-1.1	0.4	-0.9	-0.3	-0.7	0.5	0.4	0.0	0.1	0.4
High blood pressure (siblings)	0.0	0.0	0.2	0.2	0.2	-0.1	0.1	0.1	0.0	-0.0	-0.2	0.3	0.5	0.0	-0.3	0.2
Forced vital capacity (FVC), Best measure	2.3	8.3	17.0	-2.6	3.0	3.2	-0.2	2.6	-3.2	3.2	-2.0	2.7	-4.1	3.1	3.2	2.6
Body fat percentage	4.0	15.9	22.2	-4.4	4.4	3.6	-3.8	4.7	-4.4	3.4	-4.7	3.9	-0.6	4.4	3.1	4.6
Leg fat percentage (right)	2.7	9.7	16.2	-3.5	3.3	2.5	-3.6	3.7	-3.7	2.0	-4.0	3.0	0.8	3.1	2.0	3.6
Arm fat-free mass (right)	2.4	12.4	16.8	-3.7	3.7	4.1	-1.2	4.0	-3.5	3.4	-3.5	3.8	-2.1	3.7	3.9	3.9
Exposure to tobacco smoke outside home	3.3	4.4	8.0	2.5	-1.8	-2.3	-0.8	-1.8	1.6	-2.8	1.2	-1.9	2.8	-2.4	-2.5	-1.7
Comparative body size at age 10	0.1	0.3	1.4	0.5	-0.0	0.5	0.6	0.3	1.2	0.3	0.1	0.8	-0.4	-0.0	0.5	0.3
Number of full brothers	0.3	0.4	2.5	-0.3	0.4	0.1	0.8	0.1	-0.4	0.8	-0.1	0.1	-1.6	0.7	0.2	0.1
Worry too long after embarrassment	0.3	0.5	2.5	-0.4	0.8	0.2	-0.9	0.7	0.1	1.6	-0.2	0.2	0.2	1.0	-0.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	6.6	-0.4	0.3	0.4	-2.6	0.7	-0.5	-1.0	-0.9	0.9	2.0	-0.2	0.3	0.6
Wheeze or whistling in the chest in last year	0.5	1.0	4.7	0.8	-0.8	-1.2	-1.3	-0.1	1.2	-0.2	0.2	-0.5	2.2	0.2	-1.4	-0.0
Number of children fathered	0.4	0.5	1.2	0.1	-0.7	-0.7	-1.1	-0.7	-0.1	-1.0	0.2	-0.5	0.7	-1.0	-0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.3	-0.7	1.4	1.1	-0.6	1.1	0.4	1.8	-0.5	0.9	-1.5	1.3	1.0	1.0
Age at first live birth	0.7	1.2	3.5	-0.4	1.2	1.0	-0.4	1.0	-0.1	1.9	-0.0	0.5	-1.5	1.9	0.9	1.0
Pulse wave peak to peak time	0.3	0.3	1.0	1.0	-0.8	-0.6	-0.3	-0.3	0.7	0.4	0.5	-0.0	0.7	-0.1	-0.7	-0.3
Health satisfaction	0.8	1.0	1.7	-0.7	0.9	0.2	-1.2	1.3	-0.5	1.1	-1.2	1.1	1.2	1.1	-0.1	1.3
Shortness of breath walking on level ground	0.3	0.4	1.7	0.7	0.3	-0.5	0.2	-0.1	1.3	1.0	0.7	-0.4	-0.4	0.4	-0.6	-0.0
Qualifications: College or University degree	0.2	0.5	1.1	-0.4	0.6	1.0	-0.1	1.0	-0.9	-0.4	-0.8	1.0	0.6	0.2	0.8	0.9
Eye problems/disorders: None of the above	0.4	0.5	2.0	0.0	-0.7	-0.0	1.0	-0.4	0.5	-1.4	0.0	-0.4	1.1	-0.9	0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	0.2	-0.6	-0.2	0.6	-0.6	0.6	-1.0	0.2	-0.6	0.4	-1.0	-0.1	-0.6
Emphysema/chronic bronchitis	0.2	0.3	1.7	0.2	0.0	0.2	-0.5	0.2	1.3	0.5	0.2	0.0	0.9	0.1	0.3	0.2
Medication for pain relief, constipation, heartburn	0.4	0.6	5.4	-0.5	0.5	0.5	0.5	-0.1	-0.8	0.8	-0.1	-0.2	-2.3	0.2	0.8	-0.1
Neck or shoulder pain in last month	0.2	0.4	1.6	0.6	-0.2	-0.8	-0.2	-0.0	1.3	0.5	0.3	-0.2	0.8	0.5	-0.9	0.1
Medication: Blood pressure	1.2	2.1	5.1	-1.3	1.5	1.3	-0.1	1.6	-0.5	2.3	-1.1	2.0	-0.8	1.9	1.2	1.7
Angina (self-reported)	0.2	0.3	1.6	-0.1	-0.0	-0.3	-0.5	0.1	0.7	1.2	0.3	0.2	-0.5	0.7	-0.4	0.1
Migraine (self-reported)	0.6	0.7	1.9	-0.8	0.9	0.4	-1.4	0.8	-1.3	0.0	-1.3	1.0	0.3	0.5	0.5	0.8
Medication: Ibuprofen	2.6	3.1	4.8	-1.9	2.1	2.2	-0.5	2.1	-1.7	1.0	-1.9	2.0	-0.7	1.5	2.1	2.1
Medication: Allopurinol	0.3	0.4	1.8	-0.2	-0.1	-0.1	1.4	0.1	0.6	1.3	0.6	-0.1	-0.2	0.7	-0.0	-0.1
Medication: Omeprazole	2.7	3.3	5.2	2.0	-2.0	-1.8	0.4	-1.8	2.3	-1.4	2.2	-1.8	1.9	-1.5	-1.9	-1.9
Medication: Seretide 50 evohaler	0.4	0.5	1.4	1.0	-0.8	-0.6	-0.1	-0.6	0.3	-1.2	0.4	-0.5	1.1	-0.8	-0.5	-0.5
Mean time to correctly identify matches	0.3	0.5	1.5	-0.1	-0.5	-0.4	0.5	-0.9	0.8	-1.2	0.4	-0.8	0.5	-1.1	-0.2	-0.8
Heart disease (mother)	1.5	1.9	3.2	1.8	-1.3	-1.6	1.4	-1.2	1.8	0.2	1.7	-1.4	-0.4	-0.6	-1.6	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.4	1.0	-1.1	-1.0	-0.3	-0.9	0.9	-0.9	0.9	-1.0	1.2	-0.9	-1.1	-1.1
Whole body fat mass	5.1	21.2	29.9	-5.0	5.2	4.4	-3.7	5.5	-5.0	4.0	-5.4	4.7	-1.1	5.1	3.9	5.4
Leg fat mass (right)	4.2	16.3	23.7	-4.4	4.5	3.9	-3.4	4.8	-4.4	3.1	-4.9	4.2	-0.2	4.3	3.4	4.8
Arm predicted mass (right)	2.3	11.7	15.2	-3.6	3.6	3.9	-1.3	3.9	-3.6	3.2	-3.5	3.8	-1.9	3.6	3.7	3.7
Pulse rate, automated reading	0.7	2.4	11.5	1.4	-1.0	-1.1	0.1	-0.9	0.9	-2.6	0.3	-0.9	3.4	-1.8	-1.3	-0.8
Alcohol intake frequency.	0.1	0.1	0.5	-0.1	0.1	0.5	0.6	-0.0	0.0	-0.7	-0.2	0.4	0.0	-0.5	0.6	-0.0
Comparative height size at age 10	2.3	12.8	19.1	-3.3	3.8	3.6	-1.2	3.7	-3.2	4.4	-3.1	3.7	-4.1	4.2	3.5	3.7
Number of full sisters	0.5	0.6	1.4	0.8	-1.1	-0.6	1.0	-0.7	0.5	-1.1	0.6	-0.3	0.7	-1.2	-0.6	-0.6
Suffer from ‘nerves’	0.4	0.7	2.3	0.6	-0.4	-0.4	-0.9	-0.2	1.2	-1.5	-0.0	0.1	1.5	-1.0	-0.5	-0.1
Overall health rating	0.2	0.4	3.7	-0.4	0.1	0.0	-0.6	0.6	0.6	0.0	-0.4	0.3	1.9	0.5	-0.2	0.5
Chest pain or discomfort	0.2	0.3	1.3	0.4	-0.5	-0.2	0.5	-0.2	1.1	-0.6	0.2	-0.5	0.9	-0.3	-0.3	-0.1
Had major operations	0.6	0.7	2.3	1.1	-0.4	-1.1	0.5	-0.3	1.0	-0.9	0.2	-0.5	1.5	-0.4	-1.2	-0.1
Age at last live birth	0.2	0.2	0.7	0.2	0.5	0.2	-0.1	0.4	0.8	0.8	0.4	-0.1	-0.4	0.9	0.3	0.5
Family relationship satisfaction	0.5	0.6	1.4	-0.6	1.0	1.2	-0.4	0.8	-0.8	0.5	-0.6	0.3	-0.8	0.6	1.2	0.8
Leg pain on walking	0.2	0.3	1.0	0.1	-0.3	-0.8	-1.0	-0.1	-0.8	-0.1	-0.3	0.3	0.7	0.2	-0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.2	-0.0	-0.0	0.8	0.8	0.2	1.1	-0.4	0.0	0.5	-0.2	-0.4	1.0	0.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.2	-1.3	1.4	2.1	-0.0	1.5	-1.7	0.1	-1.5	1.7	0.1	0.6	1.9	1.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	0.1	-0.5	-0.7	0.7	-0.6	0.1	-0.5	0.3	-0.6	0.1	-0.8	-0.7	-0.8
Medication: Aspirin	0.3	0.4	2.1	0.0	-0.2	-0.3	-1.2	0.3	-0.4	-0.3	-0.9	0.6	1.4	-0.0	-0.5	0.4
Supplements: Vitamin C	0.6	0.7	1.9	-1.0	1.0	0.6	-0.5	0.8	-0.6	1.4	-0.7	0.6	-0.8	1.0	0.5	0.8
Knee pain experienced in last month	1.2	1.9	6.6	-0.9	1.0	0.5	-2.6	1.4	-1.8	0.2	-1.8	0.8	1.5	1.3	0.3	1.5
Hypertension (Self-reported)	0.3	0.7	2.1	-0.0	0.8	0.6	0.9	0.9	0.8	1.1	-0.3	1.4	-0.4	1.3	0.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.5	1.9	-1.9	-1.9	0.2	-1.8	1.7	-1.4	1.7	-1.5	2.1	-1.4	-2.0	-1.8
Illnesses of father: Heart disease	0.7	0.9	1.7	1.0	-1.0	-1.1	1.3	-1.0	1.2	-0.5	1.0	-1.0	-0.3	-0.7	-1.1	-0.9
Illnesses of siblings: Diabetes	0.1	0.1	0.6	-0.1	-0.0	-0.2	-0.0	0.1	-0.2	0.3	-0.2	-0.2	-0.8	0.2	-0.2	-0.0
Smoking status: Previous	0.1	0.1	0.4	0.4	-0.3	-0.2	0.2	-0.2	0.6	0.3	0.5	-0.3	0.6	0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.8	10.7	-2.5	3.3	2.9	-0.7	3.0	-2.9	3.0	-2.6	2.7	-2.8	3.2	2.8	2.9
Whole body fat-free mass	2.7	15.5	20.7	-3.9	4.3	4.3	-1.0	4.5	-4.0	4.1	-4.0	4.1	-2.5	4.5	4.0	4.4
Leg fat-free mass (right)	3.1	16.5	22.4	-4.0	4.5	4.5	-0.8	4.6	-3.7	4.5	-3.9	4.0	-3.2	4.7	4.3	4.4
Arm fat percentage (left)	2.6	10.5	15.0	-3.7	3.6	2.7	-3.2	3.9	-3.5	2.8	-3.9	3.0	-0.3	3.8	2.3	3.7
Average weekly red wine intake	0.4	0.6	1.2	-0.5	1.0	0.8	-0.8	1.1	-0.3	0.6	-0.8	1.0	0.0	0.9	0.5	0.9
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.1	-1.0	0.9	1.3	0.9	0.9	-0.9	0.4	-0.6	1.0	-0.4	0.3	1.4	0.8
Mood swings	0.4	0.7	4.3	-1.0	0.7	0.2	-2.1	0.7	-0.4	0.9	-0.4	0.2	0.6	0.9	-0.0	0.6
Loneliness, isolation	1.6	2.3	4.1	-1.7	1.4	1.7	-0.7	1.7	-1.4	1.1	-1.9	2.0	-0.3	1.2	1.7	1.8
Long-standing illness, disability or infirmity	1.9	2.9	6.3	-1.4	1.5	1.4	-2.5	2.0	-0.8	0.7	-1.9	1.9	2.2	1.4	1.2	2.0
Ever had bowel cancer screening	0.5	0.6	1.9	0.5	-0.6	-0.8	-1.4	-0.5	0.7	-0.6	0.5	-0.6	0.9	-0.3	-1.0	-0.6
Diabetes diagnosed by doctor	1.7	2.8	5.2	-2.0	1.6	1.3	-0.9	1.9	-2.3	1.6	-2.1	1.7	-0.4	1.9	1.0	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	0.1	0.5	-0.2	-0.1	0.6	-0.4	1.1	-0.2	0.6	-0.4	0.8	-0.4	0.5
Friendships satisfaction	0.4	0.5	1.3	-0.4	0.4	1.1	0.9	0.5	-1.0	0.0	-0.6	0.5	-0.3	0.0	1.2	0.5
Qualifications: nursing, teaching	0.6	0.9	6.9	-0.0	0.4	-0.1	-1.4	0.8	0.3	-0.2	-0.8	0.7	2.6	0.0	-0.3	0.8
Commuting to job workplace: Walk	1.4	1.5	3.1	1.0	-1.4	-1.1	1.0	-1.4	1.4	-0.5	1.8	-1.5	-0.7	-1.2	-1.0	-1.5
Eye problems/disorders: Cataract	0.2	0.2	0.9	-0.1	0.3	-0.4	-0.6	0.0	-0.5	1.0	-0.1	0.0	0.2	0.6	-0.5	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.7	1.8	-0.8	-1.3	0.4	-0.6	2.2	-1.1	1.2	-0.7	1.7	-0.8	-1.5	-0.6
Medication for cholesterol	0.3	0.4	2.3	0.3	-0.5	-0.4	-1.1	-0.3	-1.5	-0.3	-0.0	-0.5	0.4	-0.4	-0.3	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.7	0.3	-0.3	-0.2	-0.8	-0.1	0.0	-0.4	0.2	-0.5	0.5	-0.1	-0.5	-0.1
Back pain experienced in last month	3.3	4.8	7.4	-2.6	2.1	1.9	-1.8	2.5	-1.8	2.2	-2.5	2.5	-0.7	2.7	1.8	2.6
Mineral and other dietary supplements	0.8	1.1	6.3	0.7	-0.7	0.1	2.5	-1.0	0.9	-1.1	1.1	-0.9	-0.8	-1.1	0.4	-0.9
Breast cancer (self-reported)	1.3	1.6	3.0	-0.7	1.7	1.2	-0.2	1.5	-1.3	1.1	-1.1	1.3	-1.6	1.4	1.2	1.5
Asthma (self-reported)	0.3	0.6	2.6	1.0	-0.6	-0.6	-1.5	0.1	0.6	-0.2	-0.1	-0.1	1.6	0.3	-0.8	0.2
Osteoporosis (self-reported)	0.5	0.6	1.1	-0.5	0.7	1.0	-0.8	0.9	-0.8	-0.3	-1.0	1.0	0.6	0.0	0.9	0.9
Osteoarthritis (self-reported)	0.7	0.9	1.8	1.2	-0.9	-1.2	0.3	-0.7	1.0	-0.7	0.6	-0.9	1.2	-0.7	-1.4	-0.7
Medication: Aspirin	0.3	0.4	1.6	-0.2	-0.2	-0.2	-1.3	0.2	-0.9	-0.2	-0.9	0.5	1.0	0.1	-0.4	0.4
Medication: Gliclazide	1.2	1.4	2.6	-0.8	1.5	0.9	-1.3	1.6	-1.0	0.9	-1.6	1.3	-0.5	1.2	0.4	1.5
Illnesses of father: None of the above (group 1)	0.8	1.0	2.5	-0.9	0.9	0.3	-1.2	1.2	-1.2	0.2	-1.6	0.9	1.4	0.8	0.1	1.2
Smoking status: Current	0.6	0.9	3.0	0.6	-0.8	-1.0	0.4	-0.8	-0.0	-1.7	0.1	-1.2	1.4	-1.3	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	5.9	-2.1	1.5	1.7	-0.7	1.2	-2.2	1.4	-1.4	1.6	-2.4	1.6	1.8	1.2
Whole body water mass	2.8	16.0	21.0	-4.0	4.3	4.3	-1.0	4.6	-4.0	4.2	-4.1	4.2	-2.6	4.5	4.1	4.4
Leg predicted mass (right)	3.2	16.8	22.8	-4.0	4.5	4.5	-0.8	4.7	-3.7	4.5	-3.9	4.1	-3.2	4.8	4.4	4.5
Arm fat mass (left)	3.8	15.5	22.5	-4.3	4.4	3.7	-3.3	4.7	-4.2	3.4	-4.6	4.0	-0.7	4.4	3.3	4.6
Number of self-reported non-cancer illnesses	0.8	1.4	4.1	-0.4	0.9	-0.2	-1.6	1.4	0.2	1.9	-0.9	1.2	1.0	2.0	-0.6	1.3
Average weekly champagne plus white wine intake	2.2	3.1	5.1	1.9	-1.7	-2.2	-1.2	-1.5	1.2	-1.7	1.3	-1.7	2.3	-1.9	-2.3	-1.6
Miserableness	0.3	0.5	2.8	-0.2	0.1	-0.1	-1.7	0.3	-0.5	-0.1	-0.3	-0.0	1.6	0.1	-0.4	0.2
Guilty feelings	0.3	0.5	2.0	0.7	-0.4	-1.1	-0.1	-0.1	1.2	0.3	0.5	-0.2	0.7	0.7	-1.4	-0.1
Wears glasses or contact lenses	1.8	2.0	3.7	1.4	-1.3	-1.6	0.1	-1.4	0.8	-1.8	1.0	-1.6	1.9	-1.6	-1.7	-1.4
Ever taken oral contraceptive pill	0.7	0.8	3.1	-1.0	0.7	1.0	-1.0	0.7	-1.8	0.1	-0.8	1.1	-0.1	0.5	1.0	0.7
Hearing aid user	2.2	2.5	6.9	1.7	-1.6	-1.6	0.4	-1.6	2.6	-0.8	1.8	-1.4	1.6	-1.2	-1.4	-1.5
Mother’s age at death	0.2	0.2	1.1	0.3	-0.2	-0.9	0.0	-0.2	-0.5	0.5	0.1	-0.4	0.3	0.5	-1.1	-0.1
Financial situation satisfaction	1.2	1.4	2.9	-1.0	1.4	1.6	0.4	1.6	-0.3	0.7	-1.0	1.5	-0.6	1.1	1.6	1.7
Tinnitus: Yes, now most or all of the time	0.2	0.3	2.0	0.1	0.2	-0.1	-0.3	0.3	0.6	-0.8	-0.5	0.3	1.4	-0.3	-0.0	0.2
Commuting to job workplace: Public transport	1.7	2.0	4.1	1.8	-1.3	-1.7	0.3	-1.6	1.6	-0.8	1.5	-2.0	-0.0	-0.9	-1.6	-1.6
Eye problems/disorders: Glaucoma	1.9	2.2	4.9	-1.5	1.8	1.6	0.7	1.5	-0.5	2.2	-0.7	1.4	-1.7	1.7	1.7	1.4
Medication: Blood pressure	0.9	1.7	4.1	1.5	-1.5	-1.6	1.0	-1.2	2.0	-0.9	1.2	-0.9	0.4	-0.9	-1.8	-1.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.6	-1.2	1.2	0.8	-0.8	1.3	-0.6	1.6	-1.1	1.4	-0.8	1.9	0.7	1.4
Supplements: Fish oil (including cod liver oil)	1.6	2.0	4.9	-1.6	1.4	0.9	-1.9	1.6	-1.1	2.2	-1.4	1.4	-0.3	1.7	0.6	1.5
High cholesterol (Self-reported)	0.5	0.9	1.9	-0.9	1.2	0.7	-0.6	1.4	0.2	0.9	-1.1	1.1	0.5	1.1	0.4	1.3
Medication: Bendroflumethiazide	0.5	0.8	2.0	0.6	-1.1	-1.0	0.6	-0.9	1.4	0.8	1.1	-0.5	-1.2	-0.2	-0.9	-0.8
Medication: Paracetamol	0.1	0.2	0.6	0.7	-0.3	-0.5	0.6	-0.1	0.8	-0.1	0.4	0.0	0.5	-0.0	-0.7	-0.0
Medication: Lisinopril	0.3	0.3	1.6	-0.4	0.1	0.3	0.2	0.6	-1.3	0.1	-0.7	0.8	0.6	0.4	0.1	0.6
Medication: Atorvastatin	0.9	1.1	2.3	-1.0	1.2	1.5	0.9	1.3	0.0	-0.0	-1.1	1.3	0.1	0.6	1.4	1.3
Illnesses of father: High blood pressure	0.5	0.6	2.0	0.6	0.2	0.3	1.1	-0.3	1.4	0.8	1.0	-0.4	-1.4	0.2	0.4	-0.2
Alcohol drinker status: Never	0.4	0.5	2.3	0.5	-0.9	-0.3	1.5	-0.8	0.6	-0.4	0.8	0.0	-0.6	-0.9	-0.1	-0.8
Ever smoked	1.0	1.7	3.6	1.4	-1.4	-1.0	0.3	-1.4	0.8	-1.3	1.3	-1.9	1.2	-1.9	-1.0	-1.4
Basal metabolic rate	3.5	19.1	25.6	-4.4	4.7	4.7	-1.5	5.1	-4.5	4.4	-4.6	4.6	-2.6	4.9	4.4	4.9
Leg fat percentage (left)	2.3	8.4	14.0	-3.4	2.9	2.2	-3.6	3.3	-3.6	1.8	-3.7	2.7	0.7	2.9	1.8	3.2
Arm fat-free mass (left)	2.5	12.7	16.6	-3.7	3.6	4.0	-1.4	4.1	-3.9	3.4	-3.9	4.0	-1.8	3.7	3.7	4.0
Number of operations (self-reported)	1.3	1.9	6.0	1.1	-1.3	-1.4	-0.2	-1.1	1.4	-2.0	0.8	-1.0	2.4	-1.2	-1.5	-1.0
Average weekly beer plus cider intake	0.6	0.8	1.6	0.5	-1.3	-1.3	-0.5	-1.1	0.3	-0.0	1.2	-1.1	-0.3	-0.2	-1.3	-1.1
Irritability	1.1	1.9	4.0	-1.4	1.4	1.7	0.8	1.3	-0.9	2.0	-0.5	1.0	-1.3	1.6	1.8	1.2
Risk taking	0.1	0.2	0.6	-0.0	-0.0	-0.0	-0.8	0.3	0.1	-0.4	-0.2	0.6	0.7	0.1	0.1	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.6	0.7	-0.5	-0.7	-0.8	-0.4	0.9	-1.2	-0.2	-0.2	1.6	-0.6	-0.7	-0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.7	-0.2	-0.0	-0.1	-0.8	0.0	0.5	-0.2	-0.2	0.4	0.6	0.3	-0.1	0.1
Age started oral contraceptive pill	2.4	3.0	5.9	-2.4	1.6	2.2	-1.5	1.6	-1.0	1.6	-1.4	1.9	-1.2	1.5	2.3	1.7
Diastolic blood pressure, automated reading	1.0	3.1	7.8	-1.8	1.5	1.7	-0.0	1.4	-1.7	2.8	-1.3	1.3	-2.7	2.1	1.7	1.3
Ever depressed for a whole week	0.8	1.0	4.3	0.7	-0.6	-1.2	-1.4	-0.4	0.2	-1.2	-0.0	-0.7	2.1	-0.7	-1.4	-0.2
Unable to work because of sickness or disability	0.5	0.7	3.1	0.4	-0.3	-0.5	-1.7	-0.1	0.7	-1.1	0.0	0.2	1.8	-0.5	-0.6	-0.1
Commuting to job workplace: Cycle	1.2	1.5	3.2	-1.2	1.0	1.1	-1.6	1.1	-1.8	0.4	-1.6	1.5	-0.1	0.6	1.2	1.2
Myopia	0.1	0.2	0.8	-0.2	0.3	-0.1	-0.3	0.0	0.0	0.6	0.4	-0.9	-0.3	0.7	-0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.5	0.3	-0.6	-0.5	-0.6	-0.8	-0.7	-1.6	0.2	-1.3	0.9	-1.5	-0.2	-1.0
Cholesterol lowering medication	2.9	4.3	6.9	-2.6	2.6	2.0	-0.1	2.5	-1.1	1.7	-2.3	2.4	-1.0	2.6	1.7	2.5
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	5.8	2.3	-2.4	-2.3	0.4	-2.3	2.3	-1.3	2.4	-2.0	2.3	-1.7	-2.4	-2.2
Pain experienced in last month	0.6	1.0	3.0	1.2	-0.9	-0.2	1.7	-1.0	-0.0	-1.2	0.8	-0.9	-0.1	-1.6	-0.2	-1.1
Supplements: Calcium	1.3	1.4	5.6	-0.4	1.0	0.3	-1.9	1.4	-0.4	-0.0	-1.5	1.1	2.4	0.5	0.0	1.4
Basal cell carcinoma (self-reported)	0.5	0.6	2.1	-0.9	0.4	1.1	0.3	0.3	-1.1	-0.2	-0.7	0.4	-0.8	-0.5	1.4	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.5	0.3	-0.3	-0.5	0.3	-0.2	0.3	1.2	0.3	-0.3	-0.7	0.6	-0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.1	-0.3	-0.0	-0.3	-0.1	-0.2	0.2	-0.1	-0.2	-0.3
Heart disease (siblings)	0.6	0.7	2.1	-0.8	1.0	0.5	0.1	0.8	-0.9	0.1	-0.8	0.8	-1.5	1.2	0.4	0.8
Alcohol drinker status: Previous	0.5	0.6	1.8	-0.7	0.3	1.2	0.3	0.5	-0.2	-0.5	-0.8	1.3	0.7	-0.5	1.4	0.5
Pack years of smoking	0.2	0.3	0.7	0.7	-0.7	0.1	-0.1	-0.6	0.7	-0.7	0.9	-0.2	0.0	-0.5	0.2	-0.6
Impedance of whole body	0.1	0.4	1.9	-0.3	0.7	0.1	-0.8	0.1	-1.0	0.8	-0.0	-0.0	-1.4	0.7	0.1	0.2
Leg fat mass (left)	4.3	16.6	24.1	-4.5	4.5	3.9	-3.4	4.8	-4.5	3.1	-4.9	4.2	-0.4	4.4	3.5	4.7
Arm predicted mass (left)	2.3	11.4	14.9	-3.5	3.4	3.7	-1.4	3.9	-3.8	3.2	-3.6	3.8	-1.6	3.5	3.5	3.7